Hub : Genes

METTL15P1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.257	0.112	7.3e-03	-0.003	NA	-0.006	NA	-0.006	4.6e-01	NA	8.0e-01	NA	7.8e-01
2	GTEx	Esophagus Muscularis	0.103	0.045	2.1e-03	0.026	NA	0.008	NA	0.021	1.0e-02	NA	9.8e-02	NA	1.8e-02
3	GTEx	Skin Sun Exposed Lower leg	0.250	0.060	6.0e-08	0.072	NA	0.117	NA	0.084	1.4e-06	NA	6.2e-10	NA	2.0e-07
4	GTEx	Stomach	0.254	0.082	1.4e-03	0.010	NA	0.019	NA	0.024	1.1e-01	NA	3.9e-02	NA	2.5e-02
5	GTEx	Thyroid	0.109	0.047	5.4e-03	0.024	NA	0.017	NA	-0.003	5.5e-03	NA	1.6e-02	NA	8.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.6	1.3	1.1	-0.4	0.6	-0.5	1.1
Bipolar Disorder or Schizophrenia	0.5	1.3	3.3	1.8	-0.6	1.5	0.1	0.8
Depressed Affect (Nagel 2018)	0.1	0.2	0.5	-0.4	-0.1	0.1	-0.4	-0.7
Depression (Nagel 2018)	0.6	0.9	1.2	-1.1	-1.0	0.3	1.0	1.0
Intelligence (Savage-Jansen 2018)	1.2	3.8	9.1	1.7	3.0	1.7	1.9	0.8
Neuroticism (Nagel 2018)	0.2	0.5	1.2	-0.9	-0.3	0.7	-0.4	-1.1
Schizophrenia (2018)	0.4	0.9	2.1	1.5	-0.4	1.4	0.5	0.2
Schizophrenia vs Biploar Disorder	0.6	0.8	2.1	-0.2	-0.9	-1.5	-0.9	-0.5
Worry (Nagel 2018)	0.4	0.8	1.9	-0.9	-0.8	-0.0	-1.4	-0.6
Alzheimer’s Disease (in mother)	0.4	0.4	1.0	-1.0	-0.1	-0.3	-0.3	0.9
Alzheimer’s Disease (in father)	1.5	1.6	2.9	-0.0	1.2	1.7	1.6	1.1
Alzheimer’s Disease (including proxy)	0.5	0.8	1.1	-1.0	0.5	0.9	0.7	1.0
Crohns Disease (2017)	1.8	3.9	6.7	-2.4	-2.6	-2.1	-0.7	-1.5
Irritable Bowel Disease (IBD)	1.7	4.0	7.0	-2.6	-2.6	-1.3	-0.6	-2.0
Ulcerative Colitis (UC)	0.7	1.4	3.9	-1.3	-2.0	-0.4	0.2	-1.1
Major Depression (MDD)	0.7	0.8	1.7	-1.0	0.3	0.9	1.3	-0.7
Reaction Time	1.0	1.8	3.6	1.1	1.6	1.9	-0.5	1.2
Verbal and Numeric Reasoning (VNR)	2.1	5.0	11.4	1.0	2.2	2.7	3.4	0.6
Breast Cancer	4.5	10.8	19.3	3.2	4.1	4.4	2.1	1.7
Ovarian Cancer	6.6	8.8	12.8	-3.3	-2.7	-0.9	3.6	-3.4
Prostate Cancer	1.2	1.6	3.0	-1.7	-1.3	-1.5	0.3	-1.1
Age at First Birth	0.7	1.0	1.9	1.3	1.4	0.8	-0.2	1.0
Bipolar Disorder (2011)	0.5	0.5	1.2	-1.0	-1.1	-0.4	0.2	-0.2
Body Mass Index (BMI) (2010)	0.7	1.0	1.9	-1.0	-0.7	-1.4	-1.1	-0.6
Coronary Artery Disease (CAD)	0.3	0.3	1.3	-0.1	-0.4	-0.3	0.1	1.1
Crohns Disease (2012)	0.6	0.9	1.8	-1.1	-1.3	-1.1	0.4	0.6
Mean Putamen Volume	1.6	1.8	6.2	2.5	0.8	-0.7	-1.3	0.1
Fasting Glucose	0.7	0.9	2.5	0.6	-0.1	-1.1	-1.6	-0.5
HbA1C	0.5	0.5	1.7	0.5	0.1	0.6	0.4	1.3
HDL Cholesterol	0.5	0.9	2.3	1.5	-0.6	-0.9	-0.8	-0.8
LDL Cholesterol	1.3	2.0	6.1	2.5	1.0	-0.1	-1.3	1.1
Lupus	0.1	0.1	0.4	0.0	0.1	0.4	0.7	0.4
Neuroticism (2016)	0.3	0.4	1.4	0.6	0.1	0.2	-0.2	-1.2
Primary Biliary Cirrhosis	0.3	0.4	0.9	-0.4	0.4	-0.1	1.0	0.9
Rheumatoid Arthritis	0.2	0.2	1.0	-0.1	-1.0	-0.1	-0.1	0.4
Schizophrenia (2014)	1.0	2.2	6.5	2.5	0.1	1.8	-0.0	1.1
Triglycerides	1.6	2.7	5.2	1.7	2.3	0.9	-0.7	1.9
Type 2 Diabetes (T2D) (2012)	1.3	1.5	3.7	-1.9	-1.0	-1.2	1.1	0.2
Ulcerative Colitis	0.3	0.4	1.5	-0.2	-1.2	0.5	0.1	-0.6
Blood Eosinophil Count	0.0	0.4	0.8	-0.1	-0.3	-0.6	-0.7	0.9
Blood Platelet Count	0.2	2.1	6.2	2.5	1.5	1.1	0.8	0.1
Blood Red Count	0.5	4.4	8.1	-1.7	-0.1	-2.5	-2.2	-2.9
Blood White Count	0.3	2.2	3.7	0.5	-1.2	-1.6	-1.9	-1.6
Heel T-Score	5.9	47.2	196.0	-6.0	-14.0	-1.2	-1.5	-0.5
BMI	0.5	2.7	7.7	1.7	2.8	1.0	0.4	1.3
Height	0.5	9.6	15.4	-3.5	-3.6	-2.3	-1.2	-3.9
Waist Hip Ratio (WHR)	1.3	5.6	19.6	-0.3	-1.6	-2.0	-4.4	1.3
Systolic Blood Pressure	0.3	1.4	3.3	-1.5	-0.1	-1.8	-1.0	-0.3
Smoking Status	0.5	1.2	5.1	0.8	2.3	0.2	-0.5	-0.4
Allergy or Eczema	0.8	2.0	4.6	2.1	1.5	0.3	-1.5	0.8
Cardiovascular Disease	0.9	3.0	7.6	-2.8	-1.0	-1.7	-1.2	-1.4
Hypothyroidism (self reported)	0.8	1.9	6.3	0.1	-0.8	1.5	2.5	0.3
Respiratory disease	0.8	1.7	3.1	1.7	0.1	0.9	-1.3	1.8
Type 2 Diabetes (T2D) (2018)	1.4	2.6	9.7	1.1	3.1	-0.4	-0.4	1.4
Lung FEV1/FVC ratio	1.7	8.4	21.8	3.2	4.7	2.2	0.8	2.0
Lung FVC	0.4	2.1	7.5	-0.2	1.5	0.6	2.7	-0.2
Neuroticism	0.8	1.9	3.3	-1.3	-1.5	-0.3	-1.5	-1.8
Chronotype (morning person)	1.2	2.8	6.6	0.9	2.1	2.6	1.2	0.9
Hair Pigment	0.3	8.1	14.5	0.4	-2.9	-3.4	-3.8	-2.4
Tanning	1.6	19.9	47.2	5.4	6.9	2.5	2.9	2.8
Hand grip strength (left)	1.4	3.7	13.5	3.7	1.9	0.9	-0.6	0.5
Number of treatments/medications taken	0.2	0.3	0.8	-0.9	-0.6	0.2	-0.1	0.7
Average weekly spirits intake	0.3	0.4	0.9	0.1	-0.5	0.8	-0.2	0.9
Sensitivity / hurt feelings	1.3	2.2	4.9	-2.2	-1.4	0.9	0.4	-1.8
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.6	-0.9	-0.9	0.6	1.3	0.1
Hearing difficulty/problems: Yes	1.3	1.9	4.3	-0.4	-2.1	-0.4	-1.4	-1.7
Relative age of first facial hair	1.3	2.7	4.7	0.9	-0.3	-1.8	-2.2	-2.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.6	0.4	-0.7	0.6	1.3	0.3
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.0	-0.8	1.4	0.4	-0.3	0.6
Ever had hysterectomy (womb removed)	0.5	0.6	2.1	0.3	-0.7	1.5	0.0	0.5
Systolic blood pressure, automated reading	0.3	0.8	2.6	-0.4	0.9	0.3	-0.3	1.6
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.3	1.1	1.8	-0.9	0.2	0.7
Angina	0.4	0.5	1.1	1.1	0.6	0.2	-0.8	0.5
Medication for hormone replacement therapy	0.5	0.5	1.7	-1.3	-0.0	0.9	0.1	0.4
Vitamin and mineral supplements	0.2	0.3	0.9	0.4	0.1	-0.3	-0.9	-0.6
Supplements: Zinc	0.5	0.5	1.3	-1.1	-0.5	-0.7	-0.4	0.5
Medication: Co-codamol	0.7	0.8	1.4	1.0	0.1	0.9	0.8	1.2
Medication: Metformin	0.7	1.0	2.9	0.3	1.7	0.3	0.6	1.3
Diabetes (father)	2.7	3.3	6.4	0.7	2.0	1.9	1.5	2.5
Diabetes (mother)	0.6	0.7	2.3	0.5	1.0	0.3	1.5	-0.3
Severe depression (siblings)	0.2	0.2	0.5	0.1	0.7	0.6	0.1	-0.5
Pack years adult smoking proportion	0.6	0.9	2.6	-1.0	-0.8	-1.6	-0.4	-0.5
Impedance of leg (right)	0.5	2.5	6.2	-0.2	-2.5	-2.0	-0.6	-1.3
Leg fat-free mass (left)	0.1	0.6	1.9	-0.6	1.4	0.3	-0.6	-0.2
Trunk fat percentage	0.4	1.7	5.9	-0.2	-0.2	-1.5	-2.4	0.2
Hand grip strength (right)	2.1	5.8	18.6	4.3	2.8	1.1	-0.9	0.3
Townsend deprivation index at recruitment	0.2	0.2	0.7	0.2	0.3	-0.6	-0.8	-0.1
Current tobacco smoking	0.5	0.9	3.5	0.9	1.9	0.1	0.1	0.1
Average weekly fortified wine intake	0.3	0.4	1.1	0.8	-0.1	1.1	-0.1	-0.2
Maternal smoking around birth	2.2	3.1	5.5	-0.5	-1.7	-2.2	-1.5	-2.3
Fed-up feelings	0.6	1.1	2.9	-1.7	-1.2	-0.3	0.6	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.0	-0.4	0.4	0.1	0.3	1.0
Relative age voice broke	0.1	0.1	0.3	0.3	-0.3	-0.1	0.5	-0.2
Taking other prescription medications	0.3	0.5	1.4	-0.1	0.0	0.0	-1.2	1.1
Age when periods started (menarche)	0.1	0.3	0.9	0.2	-0.9	0.6	-0.2	0.1
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	3.6	-0.7	-0.3	0.8	-0.2	1.9
Heel bone mineral density (BMD) T-score, automated (left)	6.0	13.6	48.2	-2.7	-6.9	-2.4	-2.0	-1.7
Tinnitus: Yes, but not now, but have in the past	1.6	1.8	3.9	-2.0	-1.1	-1.1	0.0	-1.6
Qualifications: CSEs or equivalent	0.4	0.5	1.3	-0.3	1.0	0.0	-0.3	-1.2
Serious illness, injury or assault to yourself	0.8	1.0	1.5	-0.6	-0.4	-1.2	-1.2	-1.2
High blood pressure	0.5	1.5	4.7	-2.2	-1.2	-0.7	-0.7	-0.5
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.9	1.4	1.0	0.7	-0.3	1.3
Multivitamins +/- minerals	0.3	0.3	1.1	0.5	0.2	0.1	0.5	1.1
Stomach or abdominal pain in last month	1.3	1.6	2.7	-1.2	-1.6	-1.2	-0.7	-1.4
Supplements: Glucosamine	1.4	1.8	5.4	-1.1	-0.3	2.3	1.5	0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.9	-0.6	-0.9	0.0	0.1	-0.1
Medication: Atenolol	0.3	0.4	0.7	-0.2	-0.9	-0.7	-0.8	-0.2
Medication: Levothyroxine sodium	1.0	1.8	4.2	-0.4	-1.7	1.1	2.0	-0.7
Sitting height	0.4	2.6	7.8	-2.1	-0.2	-0.7	0.8	-2.8
Chronic bronchitis/emphysema (father)	0.5	0.6	2.2	-1.5	-0.7	0.2	0.5	0.5
High blood pressure (mother)	0.1	0.1	0.6	0.0	-0.2	0.0	0.8	0.2
Body mass index (BMI)	0.4	1.8	3.9	1.1	2.0	0.8	-0.4	1.9
Impedance of leg (left)	0.7	3.2	6.6	-0.5	-2.6	-2.3	-1.0	-1.7
Leg predicted mass (left)	0.1	0.5	1.7	-0.6	1.3	0.3	-0.5	-0.1
Trunk fat mass	0.3	1.2	4.5	-0.4	0.2	-1.1	-2.1	-0.0
Waist circumference	0.5	1.8	7.0	-0.3	-0.0	-0.3	-2.7	1.3
Number of incorrect matches in round	0.1	0.1	0.3	-0.2	0.4	-0.5	-0.3	0.3
Past tobacco smoking	0.5	0.9	1.7	0.4	-0.6	1.0	1.3	1.1
Alcohol usually taken with meals	1.6	2.6	4.0	1.1	1.6	1.6	1.6	2.0
Nervous feelings	0.1	0.2	0.3	-0.3	0.3	0.6	-0.3	0.5
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	3.6	-0.5	-1.0	-1.8	-1.9	-1.4
Hearing difficulty/problems with background noise	0.6	1.0	1.9	-1.2	-0.7	0.8	-0.7	-1.4
Hair/balding pattern: Pattern 2	0.8	1.0	3.8	-0.2	-2.0	-0.7	-0.9	0.1
Had menopause	0.3	0.4	1.3	0.3	1.1	0.6	0.2	0.2
Had other major operations	0.3	0.4	0.8	-0.6	-0.6	-0.4	-0.5	-0.9
Forced vital capacity (FVC)	0.2	0.6	2.2	-0.3	0.5	-0.5	0.4	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	6.4	14.7	47.0	-3.2	-6.9	-2.4	-1.9	-2.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.6	0.2	0.9	-0.4	-1.3	0.1
Qualifications: None of the above	0.3	0.6	1.9	-0.2	-1.4	-0.5	-0.7	0.3
Financial difficulties in last 2 years	0.5	0.6	1.8	-0.8	-0.7	-0.3	1.3	0.2
Mouth/teeth dental problems	0.4	0.6	2.0	1.4	0.9	0.2	-0.5	-0.3
Heart attack	0.4	0.5	1.0	0.6	0.3	-0.8	-1.0	-0.7
Allergy	0.4	1.0	2.4	-1.4	-0.4	-0.4	0.5	-1.5
Pain all over the body in last month	2.1	2.2	3.6	0.5	1.6	1.5	1.6	1.9
Diabetes (self-reported)	1.5	2.3	8.7	0.7	3.0	0.1	0.2	1.4
Hayfever/allergic rhinitis (self-reported)	1.6	2.2	3.1	0.8	1.7	1.5	1.4	1.7
Medication: Ramipril	0.7	0.8	1.2	-1.1	-1.1	-0.9	-1.0	0.2
Medication: Simvastatin	0.2	0.2	0.6	-0.3	-0.2	-0.8	-0.6	0.4
Fluid intelligence score	0.9	2.0	5.0	0.8	1.3	1.6	2.2	0.1
Illnesses of siblings	1.1	1.5	2.1	1.5	1.4	1.0	0.9	1.2
Neuroticism score	0.1	0.3	0.7	-0.6	-0.6	0.1	-0.5	-0.8
Weight	0.1	0.3	0.8	-0.3	0.8	0.1	-0.9	0.3
Impedance of arm (right)	2.3	10.7	16.7	-2.0	-4.1	-3.7	-3.5	-2.6
Arm fat percentage (right)	0.4	1.5	5.1	0.6	0.7	-0.9	-2.3	0.9
Trunk fat-free mass	0.1	0.4	0.9	-1.0	0.8	0.6	0.1	-0.2
Hip circumference	0.0	0.2	0.8	-0.9	-0.1	0.3	-0.3	0.2
Time employed in main current job	0.1	0.1	0.3	-0.3	-0.4	-0.0	0.5	-0.1
Alcohol intake versus 10 years previously	1.6	2.4	5.4	1.2	0.8	-2.0	-2.3	-0.6
Father’s age at death	4.6	6.2	11.1	1.3	2.5	3.3	3.0	1.7
Worrier / anxious feelings	0.6	1.2	2.8	-0.9	-0.4	-1.4	-1.7	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.6	-0.4	-0.2	0.7	1.3	1.0
Falls in the last year	1.0	1.4	5.1	-2.2	-1.4	0.4	0.1	-0.1
Hair/balding pattern: Pattern 3	3.8	5.6	12.2	-0.3	0.4	3.5	3.2	2.4
Number of live births	0.3	0.5	1.1	-0.7	-1.1	-0.4	0.6	0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.9	0.2	1.1	-0.2	0.6	-1.4
Pulse rate	1.5	2.5	9.1	-1.5	-3.0	0.1	0.6	-0.9
Happiness	0.0	0.0	0.1	0.1	0.1	-0.2	-0.3	0.3
Noisy workplace	0.6	0.7	1.4	-0.8	-0.5	-0.5	-1.2	-0.9
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.4	0.8	0.7	1.1	1.9	0.5
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.6	7.8	1.1	1.3	2.8	1.4	0.6
Mouth/teeth dental problems: Dentures	0.3	0.5	1.1	-0.6	-0.8	-1.1	-0.4	0.2
Asthma	0.6	1.2	2.1	1.4	-0.4	0.2	-1.4	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	0.3	-1.2	-0.2	-0.4	-0.9
Medication: Cholesterol lowering	0.8	1.2	3.8	-2.0	-0.0	0.3	1.3	0.7
Depression (self-reported)	0.2	0.2	0.5	-0.7	-0.4	-0.2	-0.6	-0.3
Medication: Lansoprazole	0.7	0.8	3.8	0.1	-2.0	-0.4	0.4	0.3
Prospective memory result	0.4	0.5	1.2	-0.9	-0.3	-1.1	-0.5	-0.5
Lung cancer (father)	2.0	2.3	5.7	-2.4	-1.4	-1.2	-0.4	-1.6
Illnesses of mother	0.6	0.7	1.9	1.0	1.4	0.2	-0.7	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	4.3	0.8	0.7	0.6	2.1	-1.0
Pulse wave Arterial Stiffness index	0.5	0.6	2.4	0.2	-0.1	0.1	-1.5	0.8
Impedance of arm (left)	1.9	8.9	12.8	-1.6	-3.6	-3.4	-3.3	-2.5
Arm fat mass (right)	0.2	0.9	3.3	0.2	0.7	-0.6	-1.8	0.7
Trunk predicted mass	0.1	0.4	1.1	-1.0	0.7	0.5	-0.0	-0.2
Standing height	0.7	7.4	13.1	-3.2	-2.8	-2.0	-1.2	-3.6
Length of working week for main job	0.8	0.8	1.5	1.2	1.0	-0.8	-1.0	-0.1
Exposure to tobacco smoke at home	1.6	1.8	4.6	0.3	-0.9	-2.1	-1.3	-1.4
Breastfed as a baby	2.6	3.2	9.6	-3.1	-1.9	-0.7	1.3	-0.9
Tense / ‘highly strung’	0.3	0.4	1.4	-0.2	-0.8	-0.2	-1.2	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	3.3	-1.8	-0.4	-0.0	-0.6	-0.4
Hair/balding pattern: Pattern 4	2.9	7.0	11.8	-3.1	-1.0	-3.2	-1.6	-3.4
Birth weight of first child	1.4	2.5	6.6	1.0	1.7	2.6	-1.4	-0.3
Peak expiratory flow (PEF)	0.2	0.5	0.9	-0.6	1.0	-0.4	0.8	-0.5
Pulse wave reflection index	1.5	1.8	4.9	1.5	2.2	0.1	-1.3	0.1
Ever highly irritable/argumentative for 2 days	0.5	0.5	0.8	0.5	-0.8	-0.8	-0.9	-0.6
Loud music exposure frequency	0.3	0.4	0.9	1.0	0.9	0.1	0.0	0.3
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	5.2	-1.4	0.0	-0.7	-0.4	-2.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.4	-0.5	0.4	0.1	-0.2
Blood clot in the leg (DVT)	0.4	0.6	1.6	-0.4	-1.2	-1.0	-0.4	-0.0
Medication: Paracetamol	0.5	0.8	1.8	-1.0	0.4	0.9	0.2	1.3
Headache pain in last month	0.3	0.5	0.7	0.8	-0.7	-0.6	-0.4	-0.8
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	6.4	2.5	0.9	0.0	-0.5	0.2
Glaucoma (self-reported)	2.7	3.2	8.7	-2.9	-2.5	0.3	0.9	0.1
Gout (self-reported)	0.7	0.9	2.5	0.7	0.7	1.6	0.9	0.4
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	5.8	0.1	-1.2	1.6	2.4	-0.0
Medication: Amlodipine	0.4	0.5	1.1	-1.1	0.4	-0.5	-0.1	1.0
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.5	0.8	-0.1	1.1	1.9	1.5
Birth weight	1.2	2.6	7.3	-1.0	0.4	2.7	0.3	2.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.8	0.3	-1.7	-0.8	-0.4	-0.2
High blood pressure (siblings)	0.6	0.9	1.6	0.7	0.3	-1.3	-1.1	-0.9
Forced vital capacity (FVC), Best measure	0.3	1.2	4.8	0.5	-0.0	0.7	2.2	-0.8
Body fat percentage	0.3	1.1	3.7	0.5	0.5	-0.8	-1.9	0.7
Leg fat percentage (right)	0.5	1.8	3.6	1.9	1.4	0.4	-0.8	1.6
Arm fat-free mass (right)	0.1	0.7	1.5	-0.5	1.2	1.0	0.8	0.4
Exposure to tobacco smoke outside home	0.6	0.8	2.6	0.1	-0.4	-0.7	-0.9	-1.6
Comparative body size at age 10	1.3	3.5	6.5	0.5	2.5	2.4	2.2	0.6
Number of full brothers	1.2	1.5	3.0	-1.3	-1.7	-0.5	0.6	-1.4
Worry too long after embarrassment	1.2	2.0	5.4	0.4	0.7	2.3	2.0	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.2	-1.8	-0.8	0.6	0.2	-0.5
Wheeze or whistling in the chest in last year	1.6	2.8	6.8	-0.7	-1.2	-1.6	-1.7	-2.6
Number of children fathered	0.9	1.1	2.0	-1.1	-1.1	-1.4	-0.5	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.5	0.1	0.1	0.7	0.5	-0.1
Age at first live birth	0.2	0.4	0.9	0.1	0.9	-1.0	-0.0	-0.6
Pulse wave peak to peak time	0.6	0.7	2.6	-0.3	-0.0	-0.1	1.6	-1.0
Health satisfaction	0.7	0.9	4.3	0.1	-2.1	0.1	0.7	0.1
Shortness of breath walking on level ground	1.9	2.2	4.9	-1.2	-0.5	-2.2	-1.8	-1.2
Qualifications: College or University degree	0.1	0.3	1.1	1.1	0.3	-0.4	0.0	-0.2
Eye problems/disorders: None of the above	0.6	0.7	2.4	1.6	0.1	-0.6	-0.4	-0.6
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.4	-0.2	-0.6	-0.2	-0.1	-0.2
Emphysema/chronic bronchitis	0.6	0.7	1.4	-1.0	-0.1	-0.8	1.2	0.8
Medication for pain relief, constipation, heartburn	0.8	1.3	4.6	2.2	1.3	0.3	0.1	-0.4
Neck or shoulder pain in last month	1.8	2.5	4.2	2.0	-0.1	1.5	1.4	2.1
Medication: Blood pressure	1.6	2.9	8.4	-2.9	-1.7	-1.1	-0.5	-1.3
Angina (self-reported)	0.4	0.5	1.7	0.7	0.4	-0.3	-1.3	0.1
Migraine (self-reported)	1.7	2.1	6.2	-2.5	-1.1	-1.4	-0.1	-1.0
Medication: Ibuprofen	0.3	0.4	1.2	-0.0	-1.1	-0.2	-0.3	-0.7
Medication: Allopurinol	0.3	0.4	1.2	0.7	-0.2	1.1	-0.3	-0.4
Medication: Omeprazole	0.2	0.3	0.5	-0.4	0.5	-0.7	-0.7	-0.4
Medication: Seretide 50 evohaler	0.8	0.9	1.3	-1.1	-1.0	-0.6	-0.9	-1.1
Mean time to correctly identify matches	0.9	1.6	5.8	0.6	0.9	2.4	-0.1	1.1
Heart disease (mother)	0.8	0.9	2.0	-1.4	-1.3	-0.8	0.5	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.5	-0.8	-0.3	-0.8	-1.2	-0.3
Whole body fat mass	0.2	0.9	3.3	0.1	0.7	-0.7	-1.8	0.5
Leg fat mass (right)	0.3	1.3	2.8	1.0	1.7	0.3	-1.0	1.3
Arm predicted mass (right)	0.1	0.5	1.2	-0.5	1.1	0.9	0.6	0.1
Pulse rate, automated reading	1.8	5.7	20.7	-2.0	-4.5	-1.6	-0.7	-1.1
Alcohol intake frequency.	0.5	1.1	2.3	0.6	-0.6	-1.5	-1.3	0.9
Comparative height size at age 10	0.5	2.6	6.5	-2.5	-1.5	-0.6	-0.1	-2.0
Number of full sisters	2.6	3.2	4.8	1.4	2.2	1.1	1.8	2.2
Suffer from ‘nerves’	0.2	0.3	0.7	-0.3	-0.3	0.8	-0.0	0.8
Overall health rating	0.6	1.2	2.9	-1.0	-1.7	-0.6	0.2	1.3
Chest pain or discomfort	1.2	1.7	5.4	0.8	-0.8	-1.3	-2.3	-0.5
Had major operations	0.9	1.0	3.0	-0.5	0.1	1.3	1.7	0.6
Age at last live birth	0.2	0.3	0.7	0.4	0.5	-0.8	0.0	-0.5
Family relationship satisfaction	1.0	1.2	3.2	1.8	1.0	1.0	-0.8	0.3
Leg pain on walking	0.5	0.6	1.3	-0.7	0.1	1.2	0.8	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.1	0.7	1.8	-0.6	1.3	0.1
Commuting to job workplace: Car/motor vehicle	1.6	1.9	4.4	1.1	-0.1	1.0	2.1	1.7
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.4	-0.1	0.4	-0.7	-0.2	0.5
Medication: Aspirin	0.9	1.2	2.7	-1.4	-0.6	-0.9	-1.6	-0.7
Supplements: Vitamin C	0.7	0.9	2.0	-1.3	-1.4	0.4	0.5	0.3
Knee pain experienced in last month	0.7	1.0	1.7	-0.1	-1.3	1.2	1.3	0.8
Hypertension (Self-reported)	0.5	1.3	3.9	-2.0	-1.0	-0.6	-0.8	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.4	0.4	-0.2	0.2	-0.3
Illnesses of father: Heart disease	0.2	0.3	1.0	0.4	-1.0	-0.1	0.2	0.3
Illnesses of siblings: Diabetes	0.9	1.1	2.1	0.7	1.4	0.3	1.0	1.3
Smoking status: Previous	0.4	0.6	1.3	-0.9	-0.1	-0.5	-0.8	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.3	-0.5	-1.4	-1.5	0.2	-1.4
Whole body fat-free mass	0.1	0.5	1.3	-0.8	1.1	0.7	-0.2	-0.0
Leg fat-free mass (right)	0.1	0.6	1.6	-0.8	1.3	0.3	-0.6	-0.3
Arm fat percentage (left)	0.4	1.5	4.7	0.8	0.8	-0.8	-2.2	0.9
Average weekly red wine intake	2.1	3.2	6.9	0.5	1.5	2.2	2.6	1.3
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.6	-1.0	-0.8	-0.1	1.6	-0.2
Mood swings	0.2	0.3	1.1	0.2	1.1	0.6	0.2	0.1
Loneliness, isolation	0.1	0.1	0.3	-0.2	-0.3	-0.3	-0.0	-0.5
Long-standing illness, disability or infirmity	0.5	0.8	3.0	0.9	0.2	0.4	0.1	1.7
Ever had bowel cancer screening	0.8	0.9	2.3	-1.2	-1.5	-0.7	-0.2	0.3
Diabetes diagnosed by doctor	1.7	2.8	8.1	1.3	2.8	0.4	0.6	1.9
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	5.8	-1.0	-2.4	-1.8	-1.2	-1.7
Friendships satisfaction	3.2	4.0	8.4	2.3	2.9	0.9	1.3	2.0
Qualifications: nursing, teaching	1.5	2.3	6.8	1.9	2.6	1.0	-0.4	-0.4
Commuting to job workplace: Walk	0.7	0.7	1.8	-0.4	1.0	-0.7	-1.3	-0.5
Eye problems/disorders: Cataract	0.2	0.2	0.5	-0.0	-0.1	0.7	0.6	0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.2	-1.1	0.1	0.1	0.3	0.8
Medication for cholesterol	0.6	0.9	2.0	0.2	0.2	-1.4	-0.8	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	3.4	-1.2	-0.5	0.4	1.8	0.6
Back pain experienced in last month	0.7	1.0	4.6	-0.2	-2.1	0.5	0.3	-0.1
Mineral and other dietary supplements	1.1	1.5	3.2	1.2	1.2	-1.8	-1.0	-0.4
Breast cancer (self-reported)	0.6	0.7	1.1	0.1	-0.7	-0.9	-0.9	-1.1
Asthma (self-reported)	0.6	1.1	2.1	1.2	-0.5	-0.1	-1.4	1.4
Osteoporosis (self-reported)	0.6	0.7	1.9	-0.2	0.9	-0.9	-1.4	-0.1
Osteoarthritis (self-reported)	3.1	4.0	10.6	-0.4	-1.2	2.2	1.8	3.3
Medication: Aspirin	1.2	1.6	3.2	-1.8	-0.9	-0.7	-1.8	-0.6
Medication: Gliclazide	0.6	0.7	2.9	0.2	-0.0	-1.7	-0.7	0.3
Illnesses of father: None of the above (group 1)	1.5	1.9	3.7	0.2	-0.2	-1.4	-1.9	-1.9
Smoking status: Current	0.7	1.1	4.2	1.2	2.0	-0.1	-0.3	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.8	0.4	1.6	1.1	1.7	-0.5
Whole body water mass	0.1	0.5	1.5	-0.8	1.2	0.6	-0.1	-0.1
Leg predicted mass (right)	0.1	0.6	1.6	-0.9	1.3	0.3	-0.5	-0.3
Arm fat mass (left)	0.2	0.9	2.8	0.3	0.7	-0.4	-1.7	0.9
Number of self-reported non-cancer illnesses	0.3	0.5	1.6	-1.3	-0.6	0.2	0.5	0.2
Average weekly champagne plus white wine intake	0.4	0.5	0.9	-0.4	-0.7	0.6	1.0	0.7
Miserableness	0.1	0.1	0.3	0.4	0.6	0.2	-0.3	-0.2
Guilty feelings	0.7	1.0	2.0	-1.4	0.3	1.3	0.8	-0.9
Wears glasses or contact lenses	0.3	0.3	0.8	-0.3	0.7	0.9	0.2	0.6
Ever taken oral contraceptive pill	0.5	0.6	1.4	-0.8	0.3	0.2	-0.8	-1.2
Hearing aid user	1.3	1.5	4.1	0.6	0.3	-1.3	-2.0	-1.2
Mother’s age at death	0.6	0.7	1.9	0.5	-0.8	-0.5	-0.7	-1.4
Financial situation satisfaction	2.0	2.4	5.3	-0.4	-0.7	-2.3	-2.2	-1.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.2	0.2	0.0	1.5	1.0	0.3
Commuting to job workplace: Public transport	0.6	0.8	2.2	-1.5	0.6	0.6	-0.1	-0.9
Eye problems/disorders: Glaucoma	3.2	3.8	10.3	-3.2	-2.8	-0.2	0.8	-0.3
Medication: Blood pressure	0.2	0.3	0.8	0.2	-0.6	0.2	-0.6	0.9
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.5	0.4	-0.7	0.6	0.0	0.7
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.7	-0.4	-0.3	1.3	0.3	0.1
High cholesterol (Self-reported)	0.5	0.9	1.6	-1.3	-0.9	0.7	1.1	0.6
Medication: Bendroflumethiazide	0.4	0.5	1.0	-1.0	-0.9	0.1	-0.1	-1.0
Medication: Paracetamol	0.5	0.7	2.0	-1.4	0.3	0.7	0.1	1.0
Medication: Lisinopril	1.1	1.4	6.5	0.1	2.5	0.5	0.5	-0.1
Medication: Atorvastatin	1.9	2.3	7.6	-2.8	-0.6	1.5	1.3	-0.1
Illnesses of father: High blood pressure	0.3	0.3	0.6	-0.7	-0.6	-0.7	0.1	0.4
Alcohol drinker status: Never	0.5	0.6	1.0	0.9	-0.7	-0.1	-1.0	0.9
Ever smoked	0.3	0.5	0.9	-0.2	0.6	-0.8	-0.9	-0.8
Basal metabolic rate	0.1	0.4	1.2	-0.6	1.1	0.4	-0.4	0.0
Leg fat percentage (left)	0.4	1.4	2.6	1.6	1.2	0.1	-1.2	1.3
Arm fat-free mass (left)	0.1	0.4	1.1	-0.4	1.1	0.8	0.5	0.3
Number of operations (self-reported)	2.4	3.5	6.9	-2.6	-2.5	-0.8	-0.0	-1.9
Average weekly beer plus cider intake	0.5	0.7	1.5	-0.6	0.2	-0.9	1.2	-1.0
Irritability	0.1	0.1	0.6	-0.1	0.3	0.0	-0.2	-0.8
Risk taking	0.7	1.0	1.6	1.2	1.1	1.3	-0.8	-0.3
Ever had prostate specific antigen (PSA) test	0.9	1.1	4.5	-0.6	-2.1	-0.3	-0.1	-0.5
Fractured/broken bones in last 5 years	0.1	0.1	0.3	-0.0	-0.1	0.4	-0.2	-0.5
Age started oral contraceptive pill	0.6	0.8	2.2	0.6	0.0	1.5	0.8	0.7
Diastolic blood pressure, automated reading	0.4	1.2	3.8	-1.9	-0.6	-0.8	-0.9	-0.6
Ever depressed for a whole week	0.5	0.6	1.8	0.6	1.3	0.7	-0.4	0.4
Unable to work because of sickness or disability	1.3	1.6	4.3	2.1	1.2	0.7	0.1	1.3
Commuting to job workplace: Cycle	0.7	0.8	1.8	-0.9	-1.3	0.0	-0.6	-1.1
Myopia	0.7	1.0	4.3	-0.7	0.2	-0.6	0.1	-2.1
Vascular/heart problems diagnosed by doctor	0.5	1.2	3.3	1.8	0.7	0.9	1.2	0.5
Cholesterol lowering medication	0.5	0.7	2.0	0.3	0.6	1.4	0.7	0.8
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	0.2	0.1	-0.5	-0.5	0.4
Pain experienced in last month	0.6	1.1	1.9	-1.2	0.8	-1.4	-0.6	-1.1
Supplements: Calcium	0.6	0.6	1.6	0.3	1.3	0.1	-1.1	-0.3
Basal cell carcinoma (self-reported)	3.1	3.7	4.0	-1.9	-2.0	-1.8	-2.0	-2.0
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.2	0.7	0.1	-0.9	-1.1	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	-0.3	-0.8	-0.8	-0.3	-0.1
Heart disease (siblings)	0.9	1.0	2.8	-1.7	-1.2	0.7	-0.0	0.7
Alcohol drinker status: Previous	1.9	2.2	3.3	-1.8	-1.4	-1.5	0.9	-1.6
Pack years of smoking	0.8	1.1	2.4	-1.2	-1.0	-1.5	-0.3	-0.7
Impedance of whole body	1.5	7.8	15.0	-1.9	-3.9	-3.3	-2.0	-2.4
Leg fat mass (left)	0.3	1.0	2.0	0.7	1.4	-0.1	-1.3	0.9
Arm predicted mass (left)	0.1	0.4	0.9	-0.4	0.9	0.8	0.5	0.4