TWAS hub - TIPARP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1309	0.0411	0.00022	0.019	NA	0.050	NA	0.022	1.1e-02	NA	8.2e-05	NA	7.2e-03
2	METSIM	Adipose	0.0715	0.0267	0.00038	0.078	0.033	0.074	0.078	0.079	8.4e-12	9.3e-06	3.3e-11	9.1e-12	6.3e-12
3	YFS	Blood	0.0243	0.0106	0.00400	0.002	0.003	-0.001	0.007	0.001	7.4e-02	3.5e-02	5.7e-01	2.0e-03	1.8e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Birth weight	32.4	70.2	204.5	-2.4	-14.3	0.5
Heel T-Score	23.3	185.6	299.3	-17.3	-15.9	2.2
Waist Hip Ratio (WHR)	19.6	88.1	249.6	-3.8	-15.8	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	13.8	31.2	61.9	-7.9	-5.6	0.3
Heel bone mineral density (BMD) T-score, automated (right)	12.4	28.4	56.7	-7.5	-5.3	-0.1
Waist circumference	5.4	19.7	50.1	-3.0	-7.1	0.2
Neuroticism	4.4	10.6	18.0	-4.2	-1.0	3.6
Falls in the last year	4.2	5.7	7.0	-2.2	-2.3	2.6
Birth weight of first child	4.2	7.7	22.8	-0.1	-4.8	0.6
Medication for cholesterol	4.2	6.4	11.9	2.6	3.5	-0.7
Age when periods started (menarche)	4.1	9.8	28.2	-1.1	-5.3	0.1
Depression (Nagel 2018)	3.9	5.8	8.2	-2.9	-1.9	2.3
Diabetes (mother)	3.9	5.0	7.5	2.7	2.7	-0.5
Medication: Omeprazole	3.9	4.7	8.0	1.9	1.5	-2.8
Medication: Omeprazole (e.g. Zanprol)	3.7	4.5	9.4	1.7	1.1	-3.1
Sitting height	3.6	25.5	47.4	5.0	6.9	-2.0
Depressed Affect (Nagel 2018)	3.5	7.4	11.3	-2.9	-1.5	3.4
Medication: Blood pressure	3.5	6.6	14.3	-1.9	-3.8	1.3
Ovarian Cancer	3.3	4.3	7.6	-1.6	1.6	-2.8
Alcohol usually taken with meals	3.3	5.4	12.4	3.5	-0.7	-1.8
Medication: Simvastatin	3.3	4.9	7.3	-2.7	-2.7	0.4
Number of full brothers	3.3	4.1	11.8	0.7	3.4	0.3
Medication: Atenolol	3.1	3.9	8.4	-1.7	-2.9	-0.7
High blood pressure (mother)	3.1	4.3	5.2	-2.1	-2.3	1.8
Medication: Ibuprofen	3.1	3.7	6.5	-2.6	-2.1	0.4
Overall health rating	3.0	6.4	9.9	-3.2	-3.0	0.2
Medication: Levothyroxine sodium	2.9	5.0	5.3	-2.3	-2.1	2.3
Supplements: Calcium	2.8	3.1	6.6	2.6	0.2	-1.6
Heart attack/myocardial infarction (self-reported)	2.8	3.6	9.1	-3.0	-0.8	1.0
Medication: Ibuprofen (e.g. Nurofen)	2.6	3.3	6.2	-2.5	-1.9	-0.1
Blood clot in the leg (DVT)	2.6	3.4	4.8	-2.2	-2.1	1.0
Exposure to tobacco smoke outside home	2.6	3.5	4.9	-2.2	-0.8	2.2
Migraine (self-reported)	2.6	3.2	6.4	1.6	2.5	-0.8
Vitamin and mineral supplements	2.5	3.4	6.4	-1.6	-1.1	2.5
Frequency of tenseness / restlessness in last 2 weeks	2.5	3.9	9.3	-3.0	-1.0	1.2
Peak expiratory flow (PEF)	2.5	5.8	12.4	1.8	3.5	-1.3
Hypothyroidism/myxoedema (self-reported)	2.5	4.8	6.4	-2.5	-2.0	2.0
Medication: Allopurinol	2.5	3.4	6.1	-1.9	-0.7	2.5
Vascular/heart problems diagnosed by doctor	2.5	6.8	13.1	2.7	3.6	-0.4
Neuroticism (Nagel 2018)	2.4	5.7	8.6	-2.9	-1.0	2.8
Coronary Artery Disease (CAD)	2.4	2.9	5.2	-2.3	-1.3	1.3
Blood Red Count	2.4	23.3	44.5	4.0	6.7	-3.0
Cardiovascular Disease	2.4	8.0	12.5	-3.5	-3.4	-0.2
Respiratory disease	2.4	5.4	14.8	-1.2	-3.8	0.1
Heart attack	2.4	3.1	7.9	-2.8	-0.6	1.1
Hayfever/allergic rhinitis (self-reported)	2.4	3.2	9.5	3.1	-0.2	-0.2
Loneliness, isolation	2.4	3.3	4.9	-2.1	-0.8	2.2
Asthma (self-reported)	2.4	4.7	13.3	-0.5	-3.6	-0.8
Osteoporosis (self-reported)	2.4	3.0	7.0	2.6	0.3	1.3
Unable to work because of sickness or disability	2.4	3.1	4.8	-2.2	-2.0	0.7
Prostate Cancer	2.3	3.3	9.4	-0.4	3.1	0.5
Hypothyroidism (self reported)	2.3	5.3	8.5	-2.9	-2.0	1.9
Taking other prescription medications	2.3	3.6	6.3	0.9	-2.5	-1.9
Impedance of arm (right)	2.3	10.8	29.8	-1.6	-5.5	0.2
Asthma	2.3	4.4	12.7	-0.6	-3.6	-0.5
Mother’s age at death	2.3	2.9	8.2	-0.1	0.6	2.9
HDL Cholesterol	2.2	3.7	9.1	0.2	3.0	1.4
Average weekly fortified wine intake	2.2	2.6	6.2	-1.3	-0.3	2.5
Allergy	2.2	5.0	14.0	0.4	3.7	-0.9
Pain all over the body in last month	2.2	2.4	3.6	-0.4	-1.9	-1.8
Neuroticism score	2.2	4.6	6.9	-2.6	-0.3	2.6
Alcohol intake versus 10 years previously	2.2	3.3	5.0	2.2	0.4	-2.2
Pulse wave reflection index	2.2	2.7	5.2	-1.0	-2.3	1.4
Eye problems/disorders: None of the above	2.2	2.5	5.3	-0.3	1.5	2.3
Blood Platelet Count	2.1	24.6	63.4	3.2	8.0	-0.3
Frequency of depressed mood in last 2 weeks	2.1	2.9	6.9	-2.6	-0.5	1.2
High blood pressure	2.1	5.8	10.4	-2.6	-3.2	0.1
Had menopause	2.1	2.6	3.5	1.6	1.3	1.9
Forced expiratory volume in 1-second (FEV1)	2.1	7.0	13.9	2.6	3.7	-0.1
Mean time to correctly identify matches	2.1	3.9	9.2	-0.4	-1.6	3.0
Hypertension (Self-reported)	2.1	5.8	11.2	-2.5	-3.3	0.1
Hearing difficulty/problems with background noise	2.0	3.1	7.3	-0.5	-1.4	2.7
Father’s age at death	2.0	2.7	4.9	2.2	1.2	1.3
Illnesses of mother	2.0	2.4	5.3	2.3	0.8	-1.1
Had major operations	2.0	2.3	3.7	-1.8	-0.0	1.9
Handedness (chirality/laterality): Left-handed	2.0	2.4	5.8	-0.1	1.1	-2.4
Worry (Nagel 2018)	1.9	4.0	6.9	-2.6	-1.1	2.0
Hearing difficulty/problems: Yes	1.9	2.8	4.5	-1.7	-1.0	2.1
Bilateral oophorectomy (both ovaries removed)	1.9	2.1	5.8	-0.1	-0.8	-2.4
Happiness	1.9	2.3	5.3	-0.7	-1.0	2.3
Hair/balding pattern: Pattern 4	1.9	4.5	6.3	1.3	2.4	-2.5
Intelligence (Savage-Jansen 2018)	1.8	5.4	12.3	1.9	3.5	0.5
Neuroticism (2016)	1.8	2.6	5.3	-0.9	-1.3	2.3
Triglycerides	1.8	2.9	4.3	1.4	-2.1	-1.6
Fed-up feelings	1.8	3.2	6.1	-2.5	0.5	1.8
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	3.2	-1.2	-1.8	1.5
Medication: Aspirin	1.8	2.3	3.1	-1.6	-1.2	1.8
Lupus	1.7	2.6	3.8	0.8	-1.9	-1.8
Systolic Blood Pressure	1.7	8.5	12.5	-3.5	-3.5	0.7
Number of treatments/medications taken	1.7	3.1	7.9	-1.1	-2.8	-0.4
Systolic blood pressure, automated reading	1.7	4.8	6.8	-2.6	-2.3	1.5
Tinnitus: Yes, but not now, but have in the past	1.7	1.9	3.6	-1.3	0.4	1.9
Multivitamins +/- minerals	1.7	2.2	4.3	1.5	0.2	-2.1
Had other major operations	1.7	2.0	6.1	-0.0	-2.5	0.2
Worrier / anxious feelings	1.7	3.2	6.1	-1.2	-1.5	2.5
Headache pain in last month	1.7	3.0	6.2	1.1	2.5	-1.2
Gout (self-reported)	1.7	2.3	3.3	-1.2	-1.5	1.8
Illnesses of father: Heart disease	1.7	2.3	4.2	-2.0	-1.6	-0.2
Number of self-reported non-cancer illnesses	1.7	2.9	8.4	-0.5	-2.9	0.2
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	3.0	-1.7	-1.7	0.9
Bipolar Disorder (2011)	1.6	1.5	2.6	0.3	1.6	-1.4
Ever had hysterectomy (womb removed)	1.6	1.8	3.2	-1.8	-0.7	1.3
Mouth/teeth dental problems	1.6	2.5	3.9	2.0	1.8	-0.6
Leg pain on walking	1.6	2.0	3.2	-0.4	-1.6	-1.8
Mood swings	1.6	2.9	4.5	-2.1	-0.9	1.9
Schizophrenia vs Biploar Disorder	1.5	2.0	3.5	-1.9	-1.2	-0.9
Type 2 Diabetes (T2D) (2018)	1.5	2.9	7.9	2.8	0.7	-0.5
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	4.5	0.6	-0.4	-2.1
Forced vital capacity (FVC)	1.5	5.7	12.2	2.2	3.5	0.3
Fluid intelligence score	1.5	3.1	7.7	0.3	2.8	1.2
Impedance of arm (left)	1.5	6.8	19.4	-1.1	-4.4	0.2
Health satisfaction	1.5	2.0	3.3	-1.3	-1.8	1.0
Chest pain or discomfort	1.5	2.2	2.9	-1.5	-1.7	1.2
Medication: Aspirin	1.5	2.0	3.0	-1.5	-0.8	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	3.4	1.3	0.3	-1.9
Smoking status: Previous	1.5	2.2	2.8	-1.7	-1.2	1.6
High cholesterol (Self-reported)	1.5	2.7	4.9	-2.2	-1.7	0.5
Blood White Count	1.4	10.7	30.9	0.2	5.6	-1.1
Medication for hormone replacement therapy	1.4	1.5	2.8	-1.7	-1.2	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	2.2	-1.2	-1.4	1.5
Leg fat percentage (right)	1.4	5.2	13.7	-1.4	-3.7	-0.1
Smoking status: Current	1.4	2.2	3.5	1.9	1.7	0.0
Ever depressed for a whole week	1.4	1.7	5.0	-0.4	-0.3	2.2
Primary Biliary Cirrhosis	1.3	1.8	4.9	0.3	2.2	-0.7
Allergy or Eczema	1.3	3.4	6.2	1.2	-2.5	1.6
Lung FEV1/FVC ratio	1.3	6.5	10.4	3.2	3.0	0.3
Sensitivity / hurt feelings	1.3	2.2	4.2	-2.0	0.1	1.5
Current tobacco smoking	1.3	2.2	4.2	1.5	2.1	-0.4
Diabetes (self-reported)	1.3	1.9	5.4	2.3	0.1	0.7
Trunk fat-free mass	1.3	7.3	11.4	3.2	3.4	-0.7
Medication: Cholesterol lowering	1.3	2.0	2.4	-1.6	-1.4	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.3	11.5	1.1	3.4	0.3
Body fat percentage	1.3	5.0	12.3	-1.6	-3.5	-0.3
Arm fat-free mass (right)	1.3	6.5	11.4	2.7	3.4	-0.9
Mouth/teeth dental problems: Loose teeth	1.3	1.5	2.8	-1.7	-0.4	1.3
Neck or shoulder pain in last month	1.3	1.8	5.1	-2.3	-0.5	0.3
Heart disease (mother)	1.3	1.6	3.8	-2.0	-0.1	-1.0
Arm predicted mass (right)	1.3	6.4	10.8	2.7	3.3	-1.2
Tinnitus: Yes, now most or all of the time	1.3	1.5	4.0	-2.0	-0.6	0.2
Age started oral contraceptive pill	1.3	1.6	4.8	-0.0	-2.2	-0.2
Angina	1.2	1.6	3.7	-0.8	-1.9	-0.6
Illnesses of siblings	1.2	1.7	3.3	1.4	-0.2	1.8
Pulse rate	1.2	2.0	2.4	-1.3	1.5	1.4
Trunk predicted mass	1.2	6.8	10.6	3.0	3.3	-0.7
Leg fat percentage (left)	1.2	4.3	10.7	-1.5	-3.3	-0.1
Arm fat-free mass (left)	1.2	6.3	12.0	2.4	3.5	-1.1
Arm predicted mass (left)	1.2	6.0	11.4	2.4	3.4	-0.9
Crohns Disease (2017)	1.1	2.3	4.2	-2.0	0.1	1.7
Reaction Time	1.1	2.2	3.8	-0.1	-1.7	1.9
Maternal smoking around birth	1.1	1.6	3.9	-0.8	2.0	-0.5
Hayfever, allergic rhinitis or eczema	1.1	2.5	4.9	1.3	-2.2	0.9
Qualifications: None of the above	1.1	2.3	5.7	-2.4	0.5	1.0
Length of working week for main job	1.1	1.3	2.5	0.9	-0.7	-1.6
Pulse wave peak to peak time	1.1	1.3	2.1	0.9	1.0	-1.5
Eye problems/disorders: Cataract	1.1	1.2	2.5	1.1	-0.0	-1.6
Risk taking	1.1	1.6	4.6	2.1	0.0	-0.4
Commuting to job workplace: Cycle	1.1	1.3	3.1	-0.2	-1.8	-0.8
Cholesterol lowering medication	1.1	1.6	2.6	-0.2	-1.5	1.6
Verbal and Numeric Reasoning (VNR)	1.0	2.4	5.4	1.3	2.3	0.1
HbA1C	1.0	1.1	2.9	-0.3	0.6	1.7
Lung FVC	1.0	5.3	15.5	0.5	3.9	0.3
Severe depression (siblings)	1.0	1.1	3.0	-0.5	-1.7	-0.3
Impedance of leg (right)	1.0	5.0	14.9	-0.1	-3.9	-0.3
Trunk fat percentage	1.0	4.0	9.2	-1.5	-3.0	-0.6
Hair/balding pattern: Pattern 2	1.0	1.2	2.1	-0.5	1.1	1.5
Arm fat percentage (right)	1.0	3.8	6.8	-2.1	-2.6	-0.3
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	3.4	1.8	1.3	0.2
Forced vital capacity (FVC), Best measure	1.0	3.6	9.3	1.0	3.1	0.6
Age at first live birth	1.0	1.7	3.0	0.9	-1.2	1.7
Medication: Blood pressure	1.0	1.7	4.1	-2.0	-1.0	-0.1
Angina (self-reported)	1.0	1.3	3.1	-0.8	-1.8	-0.6
Age at last live birth	1.0	1.4	2.0	0.4	-1.4	1.4
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	1.9	1.4	-0.4	-1.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.2	0.4	-2.0	0.6
Whole body water mass	1.0	5.4	8.4	2.7	2.9	-0.8
Average weekly beer plus cider intake	1.0	1.4	2.9	-0.9	1.7	0.7
Heart disease (siblings)	1.0	1.2	2.9	-1.7	-0.1	-0.9
Impedance of whole body	1.0	5.0	14.1	-0.9	-3.8	-0.1
Age at First Birth	0.9	1.3	3.8	-0.0	-1.9	0.4
Rheumatoid Arthritis	0.9	1.3	1.5	-1.2	-1.1	-1.1
Height	0.9	16.8	34.2	5.8	3.2	-2.5
Diabetes (father)	0.9	1.1	2.9	1.7	0.6	-0.1
Relative age voice broke	0.9	1.3	2.2	-1.5	1.0	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.4	-0.3	-0.7	1.6
Standing height	0.9	8.8	21.4	4.6	1.9	-1.2
Shortness of breath walking on level ground	0.9	1.0	2.6	-0.5	-1.6	-0.5
Emphysema/chronic bronchitis	0.9	1.0	2.8	-1.7	-0.2	0.3
Family relationship satisfaction	0.9	1.1	3.4	-0.2	-0.1	1.8
Whole body fat-free mass	0.9	5.3	8.1	2.7	2.8	-0.7
Arm fat percentage (left)	0.9	3.4	6.9	-1.8	-2.6	-0.2
Miserableness	0.9	1.6	2.5	-0.5	-1.4	1.6
Medication: Bendroflumethiazide	0.9	1.4	1.9	-1.4	-1.3	0.8
Irritable Bowel Disease (IBD)	0.8	1.8	3.6	-1.9	0.3	1.3
Schizophrenia (2014)	0.8	1.8	4.9	-0.7	-2.2	-0.4
Chronotype (morning person)	0.8	1.9	4.9	2.2	0.9	-0.1
Stomach or abdominal pain in last month	0.8	1.0	2.0	-1.0	1.4	-0.1
Supplements: Glucosamine	0.8	1.0	1.9	1.4	-0.3	-1.1
Impedance of leg (left)	0.8	4.0	11.7	-0.2	-3.4	-0.5
Nervous feelings	0.8	1.4	2.4	-1.3	-0.2	1.6
Hair/balding pattern: Pattern 3	0.8	1.1	2.5	-1.6	-0.3	0.8
Medication: Lansoprazole	0.8	0.9	1.3	-1.1	1.0	-0.6
Medication: Seretide 50 evohaler	0.8	0.9	1.5	-1.2	-0.8	0.7
Pulse rate, automated reading	0.8	2.5	4.6	-2.1	1.1	1.3
Commuting to job workplace: Walk	0.8	0.9	1.5	1.0	1.2	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.3	-1.5	0.6	0.5
Osteoarthritis (self-reported)	0.8	1.0	1.6	-1.3	-1.1	-0.6
Illnesses of father: None of the above (group 1)	0.8	1.0	2.0	0.9	1.4	-0.3
Bipolar Disorder (2018)	0.7	1.2	2.1	-1.5	-0.1	1.2
Schizophrenia (2018)	0.7	1.5	3.7	0.5	-1.9	-0.8
Ulcerative Colitis	0.7	1.0	2.0	-1.4	1.0	0.2
Past tobacco smoking	0.7	1.3	2.4	0.8	0.9	-1.6
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.7	-0.9	-0.5	1.3
Number of live births	0.7	1.0	2.1	-0.8	0.6	-1.4
Noisy workplace	0.7	0.9	1.5	-0.8	-0.6	1.2
Qualifications: A levels/AS levels or equivalent	0.7	1.5	1.8	1.3	0.9	-1.3
Lung cancer (father)	0.7	0.8	1.8	-0.8	0.2	-1.4
Pulse wave Arterial Stiffness index	0.7	0.8	1.5	-0.7	-0.7	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.4	-1.0	-1.2	-0.0
Average weekly red wine intake	0.7	1.0	2.5	1.6	-0.2	-0.7
Diabetes diagnosed by doctor	0.7	1.2	2.3	1.5	-0.2	1.1
Mineral and other dietary supplements	0.7	1.0	2.5	-1.6	0.6	0.4
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.1	1.0	-0.8	1.0
Basal metabolic rate	0.7	3.7	5.5	2.2	2.3	-0.9
Pain experienced in last month	0.7	1.2	1.6	1.1	0.8	1.3
Alcohol drinker status: Previous	0.7	0.8	1.6	-1.3	-0.3	0.9
Alzheimer’s Disease (in mother)	0.6	0.7	2.1	1.4	0.1	0.4
Breast Cancer	0.6	1.4	2.8	0.7	0.9	1.7
Type 2 Diabetes (T2D) (2012)	0.6	0.6	1.3	1.1	0.8	-0.2
Hand grip strength (right)	0.6	1.7	4.6	2.1	0.6	-0.0
Financial difficulties in last 2 years	0.6	0.8	2.4	-1.5	0.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.7	-1.0	-1.3	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	1.4	-1.2	-0.6	1.1
Loud music exposure frequency	0.6	0.6	1.1	-1.1	-0.8	-0.3
Glaucoma (self-reported)	0.6	0.7	1.2	-1.0	-1.1	-0.2
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.0	-1.4	0.0	-0.1
Medication for pain relief, constipation, heartburn	0.6	1.1	3.0	1.7	0.4	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.7	-1.3	-0.4	0.6
Leg fat-free mass (right)	0.6	3.1	5.3	2.0	2.3	-0.6
Qualifications: nursing, teaching	0.6	0.9	1.9	0.9	-0.1	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.5	-0.3	1.6	1.1
Leg predicted mass (right)	0.6	3.1	5.1	1.9	2.3	-0.6
Wears glasses or contact lenses	0.6	0.7	1.3	0.5	1.1	0.8
Financial situation satisfaction	0.6	0.7	1.2	0.3	0.9	1.1
Eye problems/disorders: Glaucoma	0.6	0.7	1.6	-1.3	-0.5	0.3
Medication: Atorvastatin	0.6	0.8	1.4	-0.2	-1.0	1.2
Illnesses of father: High blood pressure	0.6	0.7	1.1	-1.1	-0.7	0.8
Basal cell carcinoma (self-reported)	0.6	0.7	1.2	1.1	0.8	0.2
Alzheimer’s Disease (including proxy)	0.5	0.7	1.6	1.2	0.7	-0.3
Fasting Glucose	0.5	0.6	1.3	0.7	0.2	-1.1
LDL Cholesterol	0.5	0.7	1.7	1.3	0.7	0.0
Smoking Status	0.5	1.2	2.6	0.8	0.7	1.6
Tanning	0.5	5.6	9.9	3.1	-0.8	2.5
Hand grip strength (left)	0.5	1.4	3.8	1.9	0.3	-0.6
Medication: Metformin	0.5	0.7	1.1	1.1	0.8	0.4
Serious illness, injury or assault to yourself	0.5	0.6	1.5	0.6	-1.2	-0.0
Mouth/teeth dental problems: Dentures	0.5	0.8	1.5	-1.2	1.0	0.2
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.1	0.8	-1.1	-0.4
High blood pressure (siblings)	0.5	0.8	2.2	-0.0	0.4	-1.5
Comparative body size at age 10	0.5	1.3	1.8	0.6	-1.4	1.3
Worry too long after embarrassment	0.5	0.9	2.1	-1.4	-0.0	0.7
Number of children fathered	0.5	0.6	1.0	-1.0	0.8	0.4
Leg fat mass (right)	0.5	1.9	5.4	-0.5	-2.3	-0.3
Comparative height size at age 10	0.5	2.6	6.4	2.5	-0.7	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.6	1.3	0.2	0.5
Knee pain experienced in last month	0.5	0.7	1.2	-1.1	-0.9	-0.4
Illnesses of siblings: Diabetes	0.5	0.7	0.9	0.9	0.6	-0.9
Long-standing illness, disability or infirmity	0.5	0.7	1.8	-0.4	-1.3	-0.4
Average weekly champagne plus white wine intake	0.5	0.7	1.9	-0.3	-0.1	1.4
Commuting to job workplace: Public transport	0.5	0.6	0.7	-0.8	-0.8	-0.6
Number of operations (self-reported)	0.5	0.7	1.2	-1.1	-0.8	0.5
Diastolic blood pressure, automated reading	0.5	1.6	3.8	-1.9	-0.3	1.0
Bipolar Disorder or Schizophrenia	0.4	0.9	2.4	-0.5	-1.6	0.1
Body Mass Index (BMI) (2010)	0.4	0.5	1.3	-1.1	-0.5	0.1
Mean Putamen Volume	0.4	0.4	0.9	0.1	-0.7	0.9
Average weekly spirits intake	0.4	0.4	1.1	0.4	-1.0	-0.3
Supplements: Zinc	0.4	0.5	1.0	1.0	0.1	-0.6
Medication: Co-codamol	0.4	0.5	0.7	-0.8	0.5	0.7
Pack years adult smoking proportion	0.4	0.6	0.9	0.7	0.9	-0.6
Leg fat-free mass (left)	0.4	2.0	3.1	1.8	1.7	-0.5
Leg predicted mass (left)	0.4	2.0	3.0	1.7	1.7	-0.5
Trunk fat mass	0.4	1.9	5.2	-0.5	-2.3	-0.6
Time employed in main current job	0.4	0.5	0.9	-0.7	-0.0	-1.0
Depression (self-reported)	0.4	0.5	1.1	0.1	-1.1	-0.6
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.1	0.3	0.2	1.1
Whole body fat mass	0.4	1.7	4.5	-0.5	-2.1	-0.5
Number of full sisters	0.4	0.5	1.3	0.3	0.4	-1.1
Suffer from ‘nerves’	0.4	0.7	1.1	-1.0	-0.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.6	0.2	1.2	-0.8
Friendships satisfaction	0.4	0.5	1.3	1.1	-0.4	-0.3
Medication: Gliclazide	0.4	0.5	0.8	0.7	-0.5	0.9
Guilty feelings	0.4	0.6	1.6	-1.3	-0.4	0.0
Medication: Lisinopril	0.4	0.5	1.1	0.6	-0.1	-1.1
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.7	-0.8	-0.6	0.5
Pack years of smoking	0.4	0.6	0.7	0.8	0.8	-0.6
Leg fat mass (left)	0.4	1.7	4.7	-0.5	-2.2	-0.3
Alzheimer’s Disease (in father)	0.3	0.3	0.6	0.3	0.3	-0.8
Ulcerative Colitis (UC)	0.3	0.6	1.3	-1.1	0.6	0.4
Major Depression (MDD)	0.3	0.4	0.6	0.3	-0.8	-0.7
BMI	0.3	1.6	2.5	-1.2	-1.6	-0.9
Qualifications: CSEs or equivalent	0.3	0.4	0.7	0.8	-0.0	-0.6
Number of incorrect matches in round	0.3	0.5	1.3	-0.4	-0.3	1.1
Exposure to tobacco smoke at home	0.3	0.3	0.7	-0.5	0.8	-0.1
Breastfed as a baby	0.3	0.4	0.7	-0.2	0.5	-0.9
Tense / ‘highly strung’	0.3	0.5	1.2	-1.1	-0.4	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.3	-1.1	-0.1	-0.1
Wheeze or whistling in the chest in last year	0.3	0.6	1.1	-1.1	0.1	-0.8
Back pain experienced in last month	0.3	0.4	1.1	-0.3	-1.1	-0.3
Breast cancer (self-reported)	0.3	0.4	1.1	1.0	-0.2	0.1
Ever taken oral contraceptive pill	0.3	0.3	0.6	0.6	0.3	-0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.6	-0.8	-0.3	0.7
Ever smoked	0.3	0.4	0.9	-0.2	-1.0	0.6
Myopia	0.3	0.5	0.7	0.8	-0.2	0.8
Crohns Disease (2012)	0.2	0.4	0.8	-0.5	0.9	0.2
Relative age of first facial hair	0.2	0.5	0.8	0.1	0.9	0.8
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	0.5	0.1	0.8
Townsend deprivation index at recruitment	0.2	0.2	0.4	-0.2	0.5	-0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	-0.2	-0.2	-0.8
Body mass index (BMI)	0.2	0.7	2.0	-1.4	0.0	-0.3
Arm fat mass (right)	0.2	0.8	1.0	-0.9	-1.0	-0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.5	0.6	-0.6	-0.7
Alcohol intake frequency.	0.2	0.5	0.9	0.4	0.6	-1.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	0.6	-0.0	0.5
Hearing aid user	0.2	0.3	0.5	-0.7	0.5	0.2
Hair Pigment	0.1	3.3	9.7	-0.2	3.1	-0.4
Weight	0.1	0.4	0.6	0.7	0.3	-0.7
Prospective memory result	0.1	0.1	0.2	0.2	-0.0	0.4
Medication: Amlodipine	0.1	0.1	0.2	0.4	-0.2	-0.4
Qualifications: College or University degree	0.1	0.5	0.7	0.8	-0.2	-0.8
Supplements: Vitamin C	0.1	0.2	0.3	0.2	-0.5	0.5
Ever had bowel cancer screening	0.1	0.1	0.3	0.3	-0.2	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	-0.3	0.4	-0.2
Arm fat mass (left)	0.1	0.6	0.8	-0.9	-0.9	-0.5
Alcohol drinker status: Never	0.1	0.2	0.4	0.2	-0.1	0.6
Irritability	0.1	0.2	0.5	-0.1	0.2	0.7
Fractured/broken bones in last 5 years	0.1	0.1	0.3	0.2	-0.1	0.6
Blood Eosinophil Count	0.0	0.1	0.2	-0.3	0.2	-0.4
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	0.2	-0.2	0.1
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	-0.2	-0.0	0.0
Medication: Ramipril	0.0	0.0	0.1	-0.3	-0.1	-0.1
Hip circumference	0.0	0.2	0.3	-0.6	0.3	-0.3
Medication: Paracetamol	0.0	0.0	0.0	0.2	-0.0	-0.1
Medication: Paracetamol	0.0	0.1	0.2	0.0	-0.4	-0.1

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