Hub : Genes

TIPARP

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1309 0.0411 0.00022 0.019 NA 0.050 NA 0.022 1.1e-02 NA 8.2e-05 NA 7.2e-03
2 METSIM Adipose 0.0715 0.0267 0.00038 0.078 0.033 0.074 0.078 0.079 8.4e-12 9.3e-06 3.3e-11 9.1e-12 6.3e-12
3 YFS Blood 0.0243 0.0106 0.00400 0.002 0.003 -0.001 0.007 0.001 7.4e-02 3.5e-02 5.7e-01 2.0e-03 1.8e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.7 1.2 2.1 -1.5 -0.1 1.2
Bipolar Disorder or Schizophrenia 0.4 0.9 2.4 -0.5 -1.6 0.1
Depressed Affect (Nagel 2018) 3.5 7.4 11.3 -2.9 -1.5 3.4
Depression (Nagel 2018) 3.9 5.8 8.2 -2.9 -1.9 2.3
Intelligence (Savage-Jansen 2018) 1.8 5.4 12.3 1.9 3.5 0.5
Neuroticism (Nagel 2018) 2.4 5.7 8.6 -2.9 -1.0 2.8
Schizophrenia (2018) 0.7 1.5 3.7 0.5 -1.9 -0.8
Schizophrenia vs Biploar Disorder 1.5 2.0 3.5 -1.9 -1.2 -0.9
Worry (Nagel 2018) 1.9 4.0 6.9 -2.6 -1.1 2.0
Alzheimer’s Disease (in mother) 0.6 0.7 2.1 1.4 0.1 0.4
Alzheimer’s Disease (in father) 0.3 0.3 0.6 0.3 0.3 -0.8
Alzheimer’s Disease (including proxy) 0.5 0.7 1.6 1.2 0.7 -0.3
Crohns Disease (2017) 1.1 2.3 4.2 -2.0 0.1 1.7
Irritable Bowel Disease (IBD) 0.8 1.8 3.6 -1.9 0.3 1.3
Ulcerative Colitis (UC) 0.3 0.6 1.3 -1.1 0.6 0.4
Major Depression (MDD) 0.3 0.4 0.6 0.3 -0.8 -0.7
Reaction Time 1.1 2.2 3.8 -0.1 -1.7 1.9
Verbal and Numeric Reasoning (VNR) 1.0 2.4 5.4 1.3 2.3 0.1
Breast Cancer 0.6 1.4 2.8 0.7 0.9 1.7
Ovarian Cancer 3.3 4.3 7.6 -1.6 1.6 -2.8
Prostate Cancer 2.3 3.3 9.4 -0.4 3.1 0.5
Age at First Birth 0.9 1.3 3.8 -0.0 -1.9 0.4
Bipolar Disorder (2011) 1.6 1.5 2.6 0.3 1.6 -1.4
Body Mass Index (BMI) (2010) 0.4 0.5 1.3 -1.1 -0.5 0.1
Coronary Artery Disease (CAD) 2.4 2.9 5.2 -2.3 -1.3 1.3
Crohns Disease (2012) 0.2 0.4 0.8 -0.5 0.9 0.2
Mean Putamen Volume 0.4 0.4 0.9 0.1 -0.7 0.9
Fasting Glucose 0.5 0.6 1.3 0.7 0.2 -1.1
HbA1C 1.0 1.1 2.9 -0.3 0.6 1.7
HDL Cholesterol 2.2 3.7 9.1 0.2 3.0 1.4
LDL Cholesterol 0.5 0.7 1.7 1.3 0.7 0.0
Lupus 1.7 2.6 3.8 0.8 -1.9 -1.8
Neuroticism (2016) 1.8 2.6 5.3 -0.9 -1.3 2.3
Primary Biliary Cirrhosis 1.3 1.8 4.9 0.3 2.2 -0.7
Rheumatoid Arthritis 0.9 1.3 1.5 -1.2 -1.1 -1.1
Schizophrenia (2014) 0.8 1.8 4.9 -0.7 -2.2 -0.4
Triglycerides 1.8 2.9 4.3 1.4 -2.1 -1.6
Type 2 Diabetes (T2D) (2012) 0.6 0.6 1.3 1.1 0.8 -0.2
Ulcerative Colitis 0.7 1.0 2.0 -1.4 1.0 0.2
Blood Eosinophil Count 0.0 0.1 0.2 -0.3 0.2 -0.4
Blood Platelet Count 2.1 24.6 63.4 3.2 8.0 -0.3
Blood Red Count 2.4 23.3 44.5 4.0 6.7 -3.0
Blood White Count 1.4 10.7 30.9 0.2 5.6 -1.1
Heel T-Score 23.3 185.6 299.3 -17.3 -15.9 2.2
BMI 0.3 1.6 2.5 -1.2 -1.6 -0.9
Height 0.9 16.8 34.2 5.8 3.2 -2.5
Waist Hip Ratio (WHR) 19.6 88.1 249.6 -3.8 -15.8 -0.3
Systolic Blood Pressure 1.7 8.5 12.5 -3.5 -3.5 0.7
Smoking Status 0.5 1.2 2.6 0.8 0.7 1.6
Allergy or Eczema 1.3 3.4 6.2 1.2 -2.5 1.6
Cardiovascular Disease 2.4 8.0 12.5 -3.5 -3.4 -0.2
Hypothyroidism (self reported) 2.3 5.3 8.5 -2.9 -2.0 1.9
Respiratory disease 2.4 5.4 14.8 -1.2 -3.8 0.1
Type 2 Diabetes (T2D) (2018) 1.5 2.9 7.9 2.8 0.7 -0.5
Lung FEV1/FVC ratio 1.3 6.5 10.4 3.2 3.0 0.3
Lung FVC 1.0 5.3 15.5 0.5 3.9 0.3
Neuroticism 4.4 10.6 18.0 -4.2 -1.0 3.6
Chronotype (morning person) 0.8 1.9 4.9 2.2 0.9 -0.1
Hair Pigment 0.1 3.3 9.7 -0.2 3.1 -0.4
Tanning 0.5 5.6 9.9 3.1 -0.8 2.5
Hand grip strength (left) 0.5 1.4 3.8 1.9 0.3 -0.6
Number of treatments/medications taken 1.7 3.1 7.9 -1.1 -2.8 -0.4
Average weekly spirits intake 0.4 0.4 1.1 0.4 -1.0 -0.3
Sensitivity / hurt feelings 1.3 2.2 4.2 -2.0 0.1 1.5
Frequency of depressed mood in last 2 weeks 2.1 2.9 6.9 -2.6 -0.5 1.2
Hearing difficulty/problems: Yes 1.9 2.8 4.5 -1.7 -1.0 2.1
Relative age of first facial hair 0.2 0.5 0.8 0.1 0.9 0.8
Other serious medical condition/disability diagnosed by doctor 0.0 0.0 0.0 0.2 -0.2 0.1
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.6 0.5 0.1 0.8
Ever had hysterectomy (womb removed) 1.6 1.8 3.2 -1.8 -0.7 1.3
Systolic blood pressure, automated reading 1.7 4.8 6.8 -2.6 -2.3 1.5
Eye problems/disorders: Diabetes related eye disease 1.5 1.7 4.5 0.6 -0.4 -2.1
Angina 1.2 1.6 3.7 -0.8 -1.9 -0.6
Medication for hormone replacement therapy 1.4 1.5 2.8 -1.7 -1.2 -0.5
Vitamin and mineral supplements 2.5 3.4 6.4 -1.6 -1.1 2.5
Supplements: Zinc 0.4 0.5 1.0 1.0 0.1 -0.6
Medication: Co-codamol 0.4 0.5 0.7 -0.8 0.5 0.7
Medication: Metformin 0.5 0.7 1.1 1.1 0.8 0.4
Diabetes (father) 0.9 1.1 2.9 1.7 0.6 -0.1
Diabetes (mother) 3.9 5.0 7.5 2.7 2.7 -0.5
Severe depression (siblings) 1.0 1.1 3.0 -0.5 -1.7 -0.3
Pack years adult smoking proportion 0.4 0.6 0.9 0.7 0.9 -0.6
Impedance of leg (right) 1.0 5.0 14.9 -0.1 -3.9 -0.3
Leg fat-free mass (left) 0.4 2.0 3.1 1.8 1.7 -0.5
Trunk fat percentage 1.0 4.0 9.2 -1.5 -3.0 -0.6
Hand grip strength (right) 0.6 1.7 4.6 2.1 0.6 -0.0
Townsend deprivation index at recruitment 0.2 0.2 0.4 -0.2 0.5 -0.7
Current tobacco smoking 1.3 2.2 4.2 1.5 2.1 -0.4
Average weekly fortified wine intake 2.2 2.6 6.2 -1.3 -0.3 2.5
Maternal smoking around birth 1.1 1.6 3.9 -0.8 2.0 -0.5
Fed-up feelings 1.8 3.2 6.1 -2.5 0.5 1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.9 2.2 -1.2 -1.4 1.5
Relative age voice broke 0.9 1.3 2.2 -1.5 1.0 0.9
Taking other prescription medications 2.3 3.6 6.3 0.9 -2.5 -1.9
Age when periods started (menarche) 4.1 9.8 28.2 -1.1 -5.3 0.1
Bilateral oophorectomy (both ovaries removed) 1.9 2.1 5.8 -0.1 -0.8 -2.4
Heel bone mineral density (BMD) T-score, automated (left) 13.8 31.2 61.9 -7.9 -5.6 0.3
Tinnitus: Yes, but not now, but have in the past 1.7 1.9 3.6 -1.3 0.4 1.9
Qualifications: CSEs or equivalent 0.3 0.4 0.7 0.8 -0.0 -0.6
Serious illness, injury or assault to yourself 0.5 0.6 1.5 0.6 -1.2 -0.0
High blood pressure 2.1 5.8 10.4 -2.6 -3.2 0.1
Hayfever, allergic rhinitis or eczema 1.1 2.5 4.9 1.3 -2.2 0.9
Multivitamins +/- minerals 1.7 2.2 4.3 1.5 0.2 -2.1
Stomach or abdominal pain in last month 0.8 1.0 2.0 -1.0 1.4 -0.1
Supplements: Glucosamine 0.8 1.0 1.9 1.4 -0.3 -1.1
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.6 -0.2 -0.2 -0.8
Medication: Atenolol 3.1 3.9 8.4 -1.7 -2.9 -0.7
Medication: Levothyroxine sodium 2.9 5.0 5.3 -2.3 -2.1 2.3
Sitting height 3.6 25.5 47.4 5.0 6.9 -2.0
Chronic bronchitis/emphysema (father) 0.0 0.0 0.0 -0.2 -0.0 0.0
High blood pressure (mother) 3.1 4.3 5.2 -2.1 -2.3 1.8
Body mass index (BMI) 0.2 0.7 2.0 -1.4 0.0 -0.3
Impedance of leg (left) 0.8 4.0 11.7 -0.2 -3.4 -0.5
Leg predicted mass (left) 0.4 2.0 3.0 1.7 1.7 -0.5
Trunk fat mass 0.4 1.9 5.2 -0.5 -2.3 -0.6
Waist circumference 5.4 19.7 50.1 -3.0 -7.1 0.2
Number of incorrect matches in round 0.3 0.5 1.3 -0.4 -0.3 1.1
Past tobacco smoking 0.7 1.3 2.4 0.8 0.9 -1.6
Alcohol usually taken with meals 3.3 5.4 12.4 3.5 -0.7 -1.8
Nervous feelings 0.8 1.4 2.4 -1.3 -0.2 1.6
Frequency of tenseness / restlessness in last 2 weeks 2.5 3.9 9.3 -3.0 -1.0 1.2
Hearing difficulty/problems with background noise 2.0 3.1 7.3 -0.5 -1.4 2.7
Hair/balding pattern: Pattern 2 1.0 1.2 2.1 -0.5 1.1 1.5
Had menopause 2.1 2.6 3.5 1.6 1.3 1.9
Had other major operations 1.7 2.0 6.1 -0.0 -2.5 0.2
Forced vital capacity (FVC) 1.5 5.7 12.2 2.2 3.5 0.3
Heel bone mineral density (BMD) T-score, automated (right) 12.4 28.4 56.7 -7.5 -5.3 -0.1
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 1.7 -0.9 -0.5 1.3
Qualifications: None of the above 1.1 2.3 5.7 -2.4 0.5 1.0
Financial difficulties in last 2 years 0.6 0.8 2.4 -1.5 0.1 0.3
Mouth/teeth dental problems 1.6 2.5 3.9 2.0 1.8 -0.6
Heart attack 2.4 3.1 7.9 -2.8 -0.6 1.1
Allergy 2.2 5.0 14.0 0.4 3.7 -0.9
Pain all over the body in last month 2.2 2.4 3.6 -0.4 -1.9 -1.8
Diabetes (self-reported) 1.3 1.9 5.4 2.3 0.1 0.7
Hayfever/allergic rhinitis (self-reported) 2.4 3.2 9.5 3.1 -0.2 -0.2
Medication: Ramipril 0.0 0.0 0.1 -0.3 -0.1 -0.1
Medication: Simvastatin 3.3 4.9 7.3 -2.7 -2.7 0.4
Fluid intelligence score 1.5 3.1 7.7 0.3 2.8 1.2
Illnesses of siblings 1.2 1.7 3.3 1.4 -0.2 1.8
Neuroticism score 2.2 4.6 6.9 -2.6 -0.3 2.6
Weight 0.1 0.4 0.6 0.7 0.3 -0.7
Impedance of arm (right) 2.3 10.8 29.8 -1.6 -5.5 0.2
Arm fat percentage (right) 1.0 3.8 6.8 -2.1 -2.6 -0.3
Trunk fat-free mass 1.3 7.3 11.4 3.2 3.4 -0.7
Hip circumference 0.0 0.2 0.3 -0.6 0.3 -0.3
Time employed in main current job 0.4 0.5 0.9 -0.7 -0.0 -1.0
Alcohol intake versus 10 years previously 2.2 3.3 5.0 2.2 0.4 -2.2
Father’s age at death 2.0 2.7 4.9 2.2 1.2 1.3
Worrier / anxious feelings 1.7 3.2 6.1 -1.2 -1.5 2.5
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 1.7 -1.0 -1.3 -0.3
Falls in the last year 4.2 5.7 7.0 -2.2 -2.3 2.6
Hair/balding pattern: Pattern 3 0.8 1.1 2.5 -1.6 -0.3 0.8
Number of live births 0.7 1.0 2.1 -0.8 0.6 -1.4
Forced expiratory volume in 1-second (FEV1) 2.1 7.0 13.9 2.6 3.7 -0.1
Pulse rate 1.2 2.0 2.4 -1.3 1.5 1.4
Happiness 1.9 2.3 5.3 -0.7 -1.0 2.3
Noisy workplace 0.7 0.9 1.5 -0.8 -0.6 1.2
Qualifications: A levels/AS levels or equivalent 0.7 1.5 1.8 1.3 0.9 -1.3
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.4 -0.3 -0.7 1.6
Mouth/teeth dental problems: Dentures 0.5 0.8 1.5 -1.2 1.0 0.2
Asthma 2.3 4.4 12.7 -0.6 -3.6 -0.5
Medication: Ibuprofen (e.g. Nurofen) 2.6 3.3 6.2 -2.5 -1.9 -0.1
Medication: Cholesterol lowering 1.3 2.0 2.4 -1.6 -1.4 -1.2
Depression (self-reported) 0.4 0.5 1.1 0.1 -1.1 -0.6
Medication: Lansoprazole 0.8 0.9 1.3 -1.1 1.0 -0.6
Prospective memory result 0.1 0.1 0.2 0.2 -0.0 0.4
Lung cancer (father) 0.7 0.8 1.8 -0.8 0.2 -1.4
Illnesses of mother 2.0 2.4 5.3 2.3 0.8 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.3 11.5 1.1 3.4 0.3
Pulse wave Arterial Stiffness index 0.7 0.8 1.5 -0.7 -0.7 1.2
Impedance of arm (left) 1.5 6.8 19.4 -1.1 -4.4 0.2
Arm fat mass (right) 0.2 0.8 1.0 -0.9 -1.0 -0.8
Trunk predicted mass 1.2 6.8 10.6 3.0 3.3 -0.7
Standing height 0.9 8.8 21.4 4.6 1.9 -1.2
Length of working week for main job 1.1 1.3 2.5 0.9 -0.7 -1.6
Exposure to tobacco smoke at home 0.3 0.3 0.7 -0.5 0.8 -0.1
Breastfed as a baby 0.3 0.4 0.7 -0.2 0.5 -0.9
Tense / ‘highly strung’ 0.3 0.5 1.2 -1.1 -0.4 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 1.4 -1.2 -0.6 1.1
Hair/balding pattern: Pattern 4 1.9 4.5 6.3 1.3 2.4 -2.5
Birth weight of first child 4.2 7.7 22.8 -0.1 -4.8 0.6
Peak expiratory flow (PEF) 2.5 5.8 12.4 1.8 3.5 -1.3
Pulse wave reflection index 2.2 2.7 5.2 -1.0 -2.3 1.4
Ever highly irritable/argumentative for 2 days 0.4 0.4 1.1 0.3 0.2 1.1
Loud music exposure frequency 0.6 0.6 1.1 -1.1 -0.8 -0.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 0.5 0.6 -0.6 -0.7
Mouth/teeth dental problems: Bleeding gums 1.8 2.3 3.2 -1.2 -1.8 1.5
Blood clot in the leg (DVT) 2.6 3.4 4.8 -2.2 -2.1 1.0
Medication: Paracetamol 0.0 0.0 0.0 0.2 -0.0 -0.1
Headache pain in last month 1.7 3.0 6.2 1.1 2.5 -1.2
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 3.4 1.8 1.3 0.2
Glaucoma (self-reported) 0.6 0.7 1.2 -1.0 -1.1 -0.2
Gout (self-reported) 1.7 2.3 3.3 -1.2 -1.5 1.8
Hypothyroidism/myxoedema (self-reported) 2.5 4.8 6.4 -2.5 -2.0 2.0
Medication: Amlodipine 0.1 0.1 0.2 0.4 -0.2 -0.4
Medication: Ventolin 100micrograms inhaler 0.5 0.7 1.1 0.8 -1.1 -0.4
Birth weight 32.4 70.2 204.5 -2.4 -14.3 0.5
Chronic bronchitis/emphysema (mother) 0.6 0.7 2.0 -1.4 0.0 -0.1
High blood pressure (siblings) 0.5 0.8 2.2 -0.0 0.4 -1.5
Forced vital capacity (FVC), Best measure 1.0 3.6 9.3 1.0 3.1 0.6
Body fat percentage 1.3 5.0 12.3 -1.6 -3.5 -0.3
Leg fat percentage (right) 1.4 5.2 13.7 -1.4 -3.7 -0.1
Arm fat-free mass (right) 1.3 6.5 11.4 2.7 3.4 -0.9
Exposure to tobacco smoke outside home 2.6 3.5 4.9 -2.2 -0.8 2.2
Comparative body size at age 10 0.5 1.3 1.8 0.6 -1.4 1.3
Number of full brothers 3.3 4.1 11.8 0.7 3.4 0.3
Worry too long after embarrassment 0.5 0.9 2.1 -1.4 -0.0 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.3 -1.1 -0.1 -0.1
Wheeze or whistling in the chest in last year 0.3 0.6 1.1 -1.1 0.1 -0.8
Number of children fathered 0.5 0.6 1.0 -1.0 0.8 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.4 -1.0 -1.2 -0.0
Age at first live birth 1.0 1.7 3.0 0.9 -1.2 1.7
Pulse wave peak to peak time 1.1 1.3 2.1 0.9 1.0 -1.5
Health satisfaction 1.5 2.0 3.3 -1.3 -1.8 1.0
Shortness of breath walking on level ground 0.9 1.0 2.6 -0.5 -1.6 -0.5
Qualifications: College or University degree 0.1 0.5 0.7 0.8 -0.2 -0.8
Eye problems/disorders: None of the above 2.2 2.5 5.3 -0.3 1.5 2.3
Mouth/teeth dental problems: Loose teeth 1.3 1.5 2.8 -1.7 -0.4 1.3
Emphysema/chronic bronchitis 0.9 1.0 2.8 -1.7 -0.2 0.3
Medication for pain relief, constipation, heartburn 0.6 1.1 3.0 1.7 0.4 0.2
Neck or shoulder pain in last month 1.3 1.8 5.1 -2.3 -0.5 0.3
Medication: Blood pressure 1.0 1.7 4.1 -2.0 -1.0 -0.1
Angina (self-reported) 1.0 1.3 3.1 -0.8 -1.8 -0.6
Migraine (self-reported) 2.6 3.2 6.4 1.6 2.5 -0.8
Medication: Ibuprofen 3.1 3.7 6.5 -2.6 -2.1 0.4
Medication: Allopurinol 2.5 3.4 6.1 -1.9 -0.7 2.5
Medication: Omeprazole 3.9 4.7 8.0 1.9 1.5 -2.8
Medication: Seretide 50 evohaler 0.8 0.9 1.5 -1.2 -0.8 0.7
Mean time to correctly identify matches 2.1 3.9 9.2 -0.4 -1.6 3.0
Heart disease (mother) 1.3 1.6 3.8 -2.0 -0.1 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.7 -1.3 -0.4 0.6
Whole body fat mass 0.4 1.7 4.5 -0.5 -2.1 -0.5
Leg fat mass (right) 0.5 1.9 5.4 -0.5 -2.3 -0.3
Arm predicted mass (right) 1.3 6.4 10.8 2.7 3.3 -1.2
Pulse rate, automated reading 0.8 2.5 4.6 -2.1 1.1 1.3
Alcohol intake frequency. 0.2 0.5 0.9 0.4 0.6 -1.0
Comparative height size at age 10 0.5 2.6 6.4 2.5 -0.7 -0.9
Number of full sisters 0.4 0.5 1.3 0.3 0.4 -1.1
Suffer from ‘nerves’ 0.4 0.7 1.1 -1.0 -0.3 0.9
Overall health rating 3.0 6.4 9.9 -3.2 -3.0 0.2
Chest pain or discomfort 1.5 2.2 2.9 -1.5 -1.7 1.2
Had major operations 2.0 2.3 3.7 -1.8 -0.0 1.9
Age at last live birth 1.0 1.4 2.0 0.4 -1.4 1.4
Family relationship satisfaction 0.9 1.1 3.4 -0.2 -0.1 1.8
Leg pain on walking 1.6 2.0 3.2 -0.4 -1.6 -1.8
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.6 1.3 0.2 0.5
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.4 0.6 -0.0 0.5
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 1.9 1.4 -0.4 -1.2
Medication: Aspirin 1.5 2.0 3.0 -1.5 -0.8 1.7
Supplements: Vitamin C 0.1 0.2 0.3 0.2 -0.5 0.5
Knee pain experienced in last month 0.5 0.7 1.2 -1.1 -0.9 -0.4
Hypertension (Self-reported) 2.1 5.8 11.2 -2.5 -3.3 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.8 3.4 1.3 0.3 -1.9
Illnesses of father: Heart disease 1.7 2.3 4.2 -2.0 -1.6 -0.2
Illnesses of siblings: Diabetes 0.5 0.7 0.9 0.9 0.6 -0.9
Smoking status: Previous 1.5 2.2 2.8 -1.7 -1.2 1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.6 0.2 1.2 -0.8
Whole body fat-free mass 0.9 5.3 8.1 2.7 2.8 -0.7
Leg fat-free mass (right) 0.6 3.1 5.3 2.0 2.3 -0.6
Arm fat percentage (left) 0.9 3.4 6.9 -1.8 -2.6 -0.2
Average weekly red wine intake 0.7 1.0 2.5 1.6 -0.2 -0.7
Handedness (chirality/laterality): Left-handed 2.0 2.4 5.8 -0.1 1.1 -2.4
Mood swings 1.6 2.9 4.5 -2.1 -0.9 1.9
Loneliness, isolation 2.4 3.3 4.9 -2.1 -0.8 2.2
Long-standing illness, disability or infirmity 0.5 0.7 1.8 -0.4 -1.3 -0.4
Ever had bowel cancer screening 0.1 0.1 0.3 0.3 -0.2 -0.5
Diabetes diagnosed by doctor 0.7 1.2 2.3 1.5 -0.2 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.1 -0.3 0.4 -0.2
Friendships satisfaction 0.4 0.5 1.3 1.1 -0.4 -0.3
Qualifications: nursing, teaching 0.6 0.9 1.9 0.9 -0.1 1.4
Commuting to job workplace: Walk 0.8 0.9 1.5 1.0 1.2 0.2
Eye problems/disorders: Cataract 1.1 1.2 2.5 1.1 -0.0 -1.6
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 4.2 0.4 -2.0 0.6
Medication for cholesterol 4.2 6.4 11.9 2.6 3.5 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 2.3 -1.5 0.6 0.5
Back pain experienced in last month 0.3 0.4 1.1 -0.3 -1.1 -0.3
Mineral and other dietary supplements 0.7 1.0 2.5 -1.6 0.6 0.4
Breast cancer (self-reported) 0.3 0.4 1.1 1.0 -0.2 0.1
Asthma (self-reported) 2.4 4.7 13.3 -0.5 -3.6 -0.8
Osteoporosis (self-reported) 2.4 3.0 7.0 2.6 0.3 1.3
Osteoarthritis (self-reported) 0.8 1.0 1.6 -1.3 -1.1 -0.6
Medication: Aspirin 1.8 2.3 3.1 -1.6 -1.2 1.8
Medication: Gliclazide 0.4 0.5 0.8 0.7 -0.5 0.9
Illnesses of father: None of the above (group 1) 0.8 1.0 2.0 0.9 1.4 -0.3
Smoking status: Current 1.4 2.2 3.5 1.9 1.7 0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 2.5 -0.3 1.6 1.1
Whole body water mass 1.0 5.4 8.4 2.7 2.9 -0.8
Leg predicted mass (right) 0.6 3.1 5.1 1.9 2.3 -0.6
Arm fat mass (left) 0.1 0.6 0.8 -0.9 -0.9 -0.5
Number of self-reported non-cancer illnesses 1.7 2.9 8.4 -0.5 -2.9 0.2
Average weekly champagne plus white wine intake 0.5 0.7 1.9 -0.3 -0.1 1.4
Miserableness 0.9 1.6 2.5 -0.5 -1.4 1.6
Guilty feelings 0.4 0.6 1.6 -1.3 -0.4 0.0
Wears glasses or contact lenses 0.6 0.7 1.3 0.5 1.1 0.8
Ever taken oral contraceptive pill 0.3 0.3 0.6 0.6 0.3 -0.8
Hearing aid user 0.2 0.3 0.5 -0.7 0.5 0.2
Mother’s age at death 2.3 2.9 8.2 -0.1 0.6 2.9
Financial situation satisfaction 0.6 0.7 1.2 0.3 0.9 1.1
Tinnitus: Yes, now most or all of the time 1.3 1.5 4.0 -2.0 -0.6 0.2
Commuting to job workplace: Public transport 0.5 0.6 0.7 -0.8 -0.8 -0.6
Eye problems/disorders: Glaucoma 0.6 0.7 1.6 -1.3 -0.5 0.3
Medication: Blood pressure 3.5 6.6 14.3 -1.9 -3.8 1.3
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.6 -0.8 -0.3 0.7
Supplements: Fish oil (including cod liver oil) 0.7 0.9 1.1 1.0 -0.8 1.0
High cholesterol (Self-reported) 1.5 2.7 4.9 -2.2 -1.7 0.5
Medication: Bendroflumethiazide 0.9 1.4 1.9 -1.4 -1.3 0.8
Medication: Paracetamol 0.0 0.1 0.2 0.0 -0.4 -0.1
Medication: Lisinopril 0.4 0.5 1.1 0.6 -0.1 -1.1
Medication: Atorvastatin 0.6 0.8 1.4 -0.2 -1.0 1.2
Illnesses of father: High blood pressure 0.6 0.7 1.1 -1.1 -0.7 0.8
Alcohol drinker status: Never 0.1 0.2 0.4 0.2 -0.1 0.6
Ever smoked 0.3 0.4 0.9 -0.2 -1.0 0.6
Basal metabolic rate 0.7 3.7 5.5 2.2 2.3 -0.9
Leg fat percentage (left) 1.2 4.3 10.7 -1.5 -3.3 -0.1
Arm fat-free mass (left) 1.2 6.3 12.0 2.4 3.5 -1.1
Number of operations (self-reported) 0.5 0.7 1.2 -1.1 -0.8 0.5
Average weekly beer plus cider intake 1.0 1.4 2.9 -0.9 1.7 0.7
Irritability 0.1 0.2 0.5 -0.1 0.2 0.7
Risk taking 1.1 1.6 4.6 2.1 0.0 -0.4
Ever had prostate specific antigen (PSA) test 0.4 0.4 0.7 -0.8 -0.6 0.5
Fractured/broken bones in last 5 years 0.1 0.1 0.3 0.2 -0.1 0.6
Age started oral contraceptive pill 1.3 1.6 4.8 -0.0 -2.2 -0.2
Diastolic blood pressure, automated reading 0.5 1.6 3.8 -1.9 -0.3 1.0
Ever depressed for a whole week 1.4 1.7 5.0 -0.4 -0.3 2.2
Unable to work because of sickness or disability 2.4 3.1 4.8 -2.2 -2.0 0.7
Commuting to job workplace: Cycle 1.1 1.3 3.1 -0.2 -1.8 -0.8
Myopia 0.3 0.5 0.7 0.8 -0.2 0.8
Vascular/heart problems diagnosed by doctor 2.5 6.8 13.1 2.7 3.6 -0.4
Cholesterol lowering medication 1.1 1.6 2.6 -0.2 -1.5 1.6
Medication: Omeprazole (e.g. Zanprol) 3.7 4.5 9.4 1.7 1.1 -3.1
Pain experienced in last month 0.7 1.2 1.6 1.1 0.8 1.3
Supplements: Calcium 2.8 3.1 6.6 2.6 0.2 -1.6
Basal cell carcinoma (self-reported) 0.6 0.7 1.2 1.1 0.8 0.2
Heart attack/myocardial infarction (self-reported) 2.8 3.6 9.1 -3.0 -0.8 1.0
Deep venous thrombosis (DVT) (self-reported) 1.7 2.2 3.0 -1.7 -1.7 0.9
Heart disease (siblings) 1.0 1.2 2.9 -1.7 -0.1 -0.9
Alcohol drinker status: Previous 0.7 0.8 1.6 -1.3 -0.3 0.9
Pack years of smoking 0.4 0.6 0.7 0.8 0.8 -0.6
Impedance of whole body 1.0 5.0 14.1 -0.9 -3.8 -0.1
Leg fat mass (left) 0.4 1.7 4.7 -0.5 -2.2 -0.3
Arm predicted mass (left) 1.2 6.0 11.4 2.4 3.4 -0.9