[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) : ← →

chr4:69,713-2,058,475

Best TWAS P=1.84e-39 · Best GWAS P=8.49e-31 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
48	GTEx	Thyroid	FGFRL1	0.39	0.05	enet	47	0.14	6.9e-11	9.08	13.1	1.8e-39	-0.33	0.67	0.31	TRUE
2	CommonMind	Brain Pre-frontal Cortex	FGFRL1	0.03	0.00	enet	7	0.01	1.7e-02	1.16	-8.8	1.1e-18	0.71	0.01	0.95	TRUE
37	GTEx	Lung	CRIPAK	0.61	0.22	enet	46	0.41	1.1e-33	-6.66	-7.5	4.6e-14	-0.08	1.00	0.00	TRUE
56	NTR	Blood	CRIPAK	0.13	0.09	enet	31	0.15	1.5e-46	-5.12	-6.8	1.0e-11	-0.11	1.00	0.00	TRUE
30	GTEx	Esophagus Gastroesophageal Junction	CRIPAK	0.33	0.20	lasso	5	0.30	1.4e-11	-6.66	-6.8	1.5e-11	-0.11	0.99	0.00	TRUE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	KIAA1530	0.13	0.01	blup	48	0.03	4.9e-07	-4.49	-6.4	2.1e-10	-0.01	0.79	0.15	TRUE
44	GTEx	Ovary	CRIPAK	0.43	0.27	enet	19	0.32	9.0e-09	-6.66	-6.2	4.0e-10	-0.12	0.46	0.05	TRUE
82	The Cancer Genome Atlas	Thyroid Carcinoma	IDUA	0.19	0.04	enet	16	0.11	3.5e-11	-1.55	-5.6	2.0e-08	0.37	0.87	0.06	TRUE
31	GTEx	Esophagus Mucosa	CRIPAK	0.49	0.14	enet	28	0.40	6.8e-29	-6.66	-5.4	6.2e-08	-0.21	1.00	0.00	TRUE
49	GTEx	Thyroid	CRIPAK	0.51	0.14	enet	44	0.34	6.1e-27	1.44	-5.4	7.7e-08	-0.09	1.00	0.00	TRUE
81	The Cancer Genome Atlas	Thyroid Carcinoma	FGFRL1	0.34	0.05	enet	32	0.17	1.2e-16	9.08	9.4	5.0e-21	-0.30	0.05	0.87	FALSE
8	GTEx	Artery Tibial	FGFRL1	0.08	0.00	enet	29	0.05	6.5e-05	1.07	9.1	1.0e-19	-0.23	0.16	0.30	FALSE
11	GTEx	Brain Cerebellum	FGFRL1	0.32	0.01	enet	41	0.11	3.8e-04	4.42	8.1	4.8e-16	-0.55	0.06	0.46	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	CRIPAK	0.34	0.13	lasso	6	0.25	2.7e-07	-6.66	-7.5	4.9e-14	-0.02	0.21	0.04	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	CRIPAK	0.49	0.27	lasso	8	0.35	2.9e-12	-6.66	-7.4	1.0e-13	-0.05	0.84	0.01	FALSE
61	The Cancer Genome Atlas	Breast Invasive Carcinoma	CRIPAK	0.22	0.11	blup	28	0.14	5.6e-28	-4.41	-7.4	1.8e-13	-0.06	1.00	0.00	FALSE
14	GTEx	Brain Cortex	CRIPAK	0.34	0.10	lasso	6	0.18	9.5e-06	-6.66	-7.3	2.8e-13	-0.11	0.20	0.05	FALSE
17	GTEx	Brain Hypothalamus	CRIPAK	0.22	0.00	lasso	5	0.01	2.1e-01	-5.58	-7.2	6.4e-13	-0.06	0.06	0.05	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	UVSSA	0.30	0.00	enet	23	0.08	1.1e-03	-6.66	-7.2	7.0e-13	-0.05	0.29	0.04	FALSE
52	METSIM	Adipose	CRIPAK	0.28	0.16	bslmm	335	0.25	2.7e-37	-4.17	-7.1	9.0e-13	-0.08	1.00	0.00	FALSE
6	GTEx	Adipose Visceral Omentum	CRIPAK	0.47	0.24	lasso	12	0.31	1.3e-16	-6.66	-7.1	1.1e-12	-0.10	1.00	0.00	FALSE
59	YFS	Blood	CRIPAK	0.35	0.27	bslmm	301	0.33	6.0e-112	-4.41	-7.1	1.1e-12	-0.10	1.00	0.00	FALSE
74	The Cancer Genome Atlas	Prostate Adenocarcinoma	IDUA	0.13	0.01	blup	51	0.10	6.0e-11	0.35	-7.1	1.7e-12	0.26	0.86	0.02	FALSE
76	The Cancer Genome Atlas	Soft Tissue Sarcoma	CRIPAK	0.20	0.10	lasso	5	0.15	2.2e-09	-6.66	-7.0	2.3e-12	-0.05	0.00	1.00	FALSE
51	GTEx	Whole Blood	CRIPAK	0.38	0.17	lasso	9	0.28	3.4e-26	-4.41	-7.0	2.5e-12	-0.12	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CRIPAK	0.28	0.16	blup	28	0.19	3.2e-21	-4.41	-7.0	2.6e-12	-0.10	0.97	0.03	FALSE
50	GTEx	Uterus	CRIPAK	0.52	0.34	lasso	3	0.33	1.7e-07	-5.58	-6.9	5.6e-12	-0.03	0.24	0.05	FALSE
10	GTEx	Brain Caudate basal ganglia	CRIPAK	0.27	0.00	lasso	2	0.02	9.3e-02	-5.58	-6.8	1.3e-11	-0.03	0.06	0.08	FALSE
64	The Cancer Genome Atlas	Colon Adenocarcinoma	CRIPAK	0.38	0.16	blup	28	0.21	2.8e-12	-4.41	-6.7	1.6e-11	-0.12	0.11	0.89	FALSE
55	METSIM	Adipose	UVSSA	0.26	0.04	bslmm	366	0.12	9.0e-18	-0.41	-6.7	1.8e-11	-0.06	1.00	0.00	FALSE
38	GTEx	Lung	RP11-20I20.4	0.07	0.00	lasso	3	0.01	6.0e-02	-6.18	-6.6	4.3e-11	0.01	0.14	0.03	FALSE
33	GTEx	Esophagus Muscularis	RNF212	0.13	0.00	lasso	6	0.00	8.6e-01	4.31	6.6	4.9e-11	-0.12	0.17	0.07	FALSE
36	GTEx	Heart Left Ventricle	CRIPAK	0.19	0.05	enet	24	0.21	3.4e-11	-6.66	-6.6	5.0e-11	-0.10	0.65	0.02	FALSE
79	The Cancer Genome Atlas	Stomach Adenocarcinoma	CRIPAK	0.17	0.07	blup	29	0.08	1.3e-06	-6.98	-6.6	5.2e-11	-0.07	0.00	1.00	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	CRIPAK	0.38	0.22	enet	12	0.25	5.4e-24	-4.41	-6.5	6.1e-11	-0.10	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CRIPAK	0.31	0.15	enet	34	0.26	1.2e-31	-4.52	-6.5	7.5e-11	-0.07	1.00	0.00	FALSE
26	GTEx	Colon Sigmoid	CRIPAK	0.40	0.21	lasso	7	0.30	4.7e-11	-6.18	-6.5	7.7e-11	0.00	0.72	0.01	FALSE
45	GTEx	Pancreas	CRIPAK	0.34	0.13	lasso	6	0.27	1.0e-11	-4.41	-6.5	1.1e-10	-0.13	0.84	0.01	FALSE
28	GTEx	Colon Transverse	RP11-20I20.4	0.17	0.05	lasso	3	0.05	2.3e-03	-6.18	-6.4	1.7e-10	0.08	0.42	0.04	FALSE
9	GTEx	Artery Tibial	MYL5	0.15	0.10	lasso	5	0.08	9.0e-07	-6.38	-6.3	2.5e-10	0.33	1.00	0.00	FALSE
40	GTEx	Nerve Tibial	TMEM175	0.08	0.05	lasso	5	0.03	3.0e-03	-6.38	6.3	2.5e-10	-0.38	0.35	0.03	FALSE
75	The Cancer Genome Atlas	Rectum Adenocarcinoma	CRIPAK	0.37	0.07	lasso	2	0.12	1.2e-03	-4.41	-6.3	2.6e-10	-0.12	0.01	0.62	FALSE
35	GTEx	Heart Atrial Appendage	CRIPAK	0.31	0.26	enet	23	0.33	2.1e-15	-6.66	-6.3	3.8e-10	-0.10	1.00	0.00	FALSE
16	GTEx	Brain Hippocampus	CRIPAK	0.48	0.22	lasso	4	0.23	4.0e-06	-4.41	-6.3	3.9e-10	-0.18	0.20	0.05	FALSE
22	GTEx	Breast Mammary Tissue (Male)	CPLX1	0.24	0.01	lasso	2	0.06	1.7e-02	9.08	6.2	6.5e-10	0.03	0.04	0.05	FALSE
23	GTEx	Breast Mammary Tissue (Female)	CRIPAK	0.32	0.17	enet	29	0.26	2.7e-08	-4.51	-6.2	7.0e-10	-0.11	0.54	0.02	FALSE
21	GTEx	Breast Mammary Tissue	CRIPAK	0.42	0.12	enet	35	0.39	5.2e-21	-6.66	-6.1	1.4e-09	-0.10	1.00	0.00	FALSE
34	GTEx	Esophagus Muscularis	CRIPAK	0.38	0.14	enet	34	0.30	2.6e-18	-6.66	-6.1	1.4e-09	-0.09	1.00	0.00	FALSE
20	GTEx	Brain Putamen basal ganglia	CRIPAK	0.30	0.00	enet	25	0.10	1.9e-03	-4.07	-6.0	1.8e-09	-0.09	0.06	0.06	FALSE
78	The Cancer Genome Atlas	Skin Cutaneous Melanoma	CRIPAK	0.57	0.07	enet	9	0.23	6.7e-07	-6.66	-6.0	2.3e-09	-0.06	0.01	0.90	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	CRIPAK	0.31	0.11	enet	10	0.18	1.5e-19	-4.41	-5.9	3.2e-09	-0.14	0.99	0.01	FALSE
7	GTEx	Artery Aorta	CRIPAK	0.31	0.20	enet	34	0.30	2.8e-17	-6.66	-5.9	3.3e-09	-0.13	1.00	0.00	FALSE
39	GTEx	Muscle Skeletal	CRIPAK	0.25	0.11	enet	32	0.18	7.6e-18	-6.66	-5.9	4.3e-09	-0.13	1.00	0.00	FALSE
32	GTEx	Esophagus Muscularis	UVSSA	0.35	0.03	enet	33	0.16	3.5e-10	-6.66	-5.9	4.4e-09	-0.07	0.94	0.00	FALSE
4	GTEx	Adipose Subcutaneous	CRIPAK	0.42	0.11	enet	42	0.34	9.0e-29	-4.50	-5.8	5.0e-09	-0.19	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	UVSSA	0.46	0.05	lasso	11	0.24	1.1e-12	-5.58	-5.8	5.5e-09	-0.16	0.88	0.01	FALSE
47	GTEx	Spleen	CRIPAK	0.35	0.08	lasso	5	0.25	4.6e-07	-4.41	-5.8	6.8e-09	0.05	0.16	0.05	FALSE
15	GTEx	Brain Frontal Cortex BA9	CRIPAK	0.36	0.03	lasso	7	0.05	1.9e-02	-6.66	-5.7	9.7e-09	-0.08	0.06	0.05	FALSE
57	NTR	Blood	KIAA1530	0.19	0.04	blup	345	0.10	9.1e-32	-5.58	-5.7	9.7e-09	0.00	1.00	0.00	FALSE
13	GTEx	Brain Cortex	RNF212	0.15	0.03	lasso	3	0.01	1.5e-01	-4.92	5.7	1.1e-08	-0.10	0.10	0.11	FALSE
63	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CRIPAK	0.17	0.06	blup	29	0.11	4.2e-06	-4.07	-5.7	1.3e-08	-0.10	0.01	0.98	FALSE
73	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CRIPAK	0.41	0.10	lasso	4	0.08	5.2e-04	-4.41	-5.7	1.6e-08	-0.12	0.10	0.26	FALSE
19	GTEx	Brain Putamen basal ganglia	RNF212	0.23	0.07	lasso	19	0.05	2.6e-02	4.03	5.6	1.9e-08	-0.07	0.13	0.07	FALSE
41	GTEx	Nerve Tibial	CRIPAK	0.50	0.11	enet	76	0.38	1.1e-28	-4.41	-5.6	1.9e-08	-0.17	1.00	0.00	FALSE
12	GTEx	Brain Cerebellum	CRIPAK	0.37	0.09	enet	24	0.31	8.8e-10	-4.49	-5.6	2.4e-08	-0.17	0.40	0.06	FALSE
46	GTEx	Skin Sun Exposed Lower leg	CRIPAK	0.36	0.09	enet	40	0.35	8.7e-30	-4.50	-5.5	4.3e-08	-0.17	1.00	0.00	FALSE
42	GTEx	Nerve Tibial	CTBP1-AS2	0.18	0.03	lasso	5	0.03	3.2e-03	-5.11	-5.5	5.0e-08	-0.07	0.61	0.02	FALSE
69	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CRIPAK	0.13	0.06	blup	29	0.08	1.2e-04	-4.41	-5.4	5.2e-08	-0.15	0.06	0.36	FALSE
54	METSIM	Adipose	SPON2	0.06	0.06	lasso	8	0.05	2.2e-08	-4.89	-5.4	6.3e-08	0.04	1.00	0.00	FALSE
43	GTEx	Ovary	UVSSA	0.33	0.10	enet	12	0.32	1.5e-08	-5.58	-5.4	6.9e-08	-0.07	0.11	0.08	FALSE
71	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CRIPAK	0.34	0.13	blup	29	0.19	3.9e-13	-6.66	-5.4	8.4e-08	-0.09	0.01	0.99	FALSE
65	The Cancer Genome Atlas	Glioblastoma Multiforme	CRIPAK	0.35	0.15	lasso	5	0.14	4.3e-05	-4.07	-5.3	8.8e-08	-0.10	0.00	0.88	FALSE
77	The Cancer Genome Atlas	Soft Tissue Sarcoma	KIAA1530	0.08	0.03	enet	11	0.03	5.9e-03	-4.32	-5.3	9.4e-08	-0.11	0.03	0.54	FALSE
27	GTEx	Colon Transverse	CRIPAK	0.33	0.10	enet	22	0.24	5.8e-12	-4.41	-5.3	1.1e-07	-0.15	0.97	0.00	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CRIPAK	0.21	0.10	enet	9	0.15	1.3e-16	-4.41	-5.3	1.3e-07	-0.16	1.00	0.00	FALSE
70	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CRIPAK	0.14	0.05	lasso	4	0.07	6.1e-08	-4.41	-5.2	1.5e-07	-0.14	0.86	0.14	FALSE
25	GTEx	Cells Transformed fibroblasts	CRIPAK	0.35	0.06	enet	33	0.22	3.0e-16	-4.41	-5.2	2.1e-07	-0.17	1.00	0.00	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	CRIPAK	0.31	0.23	lasso	12	0.40	6.4e-55	-4.17	-5.2	2.1e-07	-0.11	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	RNF212	0.14	0.11	lasso	6	0.11	2.3e-13	-4.89	5.2	2.2e-07	-0.03	1.00	0.00	FALSE
60	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CRIPAK	0.11	0.07	lasso	4	0.05	2.0e-05	-4.41	-5.2	2.2e-07	-0.14	0.29	0.55	FALSE
53	METSIM	Adipose	MAEA	0.10	0.03	bslmm	392	0.07	4.4e-10	-6.66	5.2	2.5e-07	0.03	0.99	0.00	FALSE
72	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	KIAA1530	0.40	0.10	blup	49	0.10	2.0e-07	-6.66	-5.2	2.5e-07	-0.09	0.01	0.99	FALSE