TWAS hub - EYA4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1500	0.0340	1.7e-12	0.066	0.120	0.105	0.118	0.107	2.0e-08	2.0e-14	1.1e-12	3.1e-14	6.4e-13
2	ROSMAP	Brain Pre-frontal Cortex	0.2568	0.0472	3.2e-13	0.101	0.138	0.166	0.188	0.159	5.9e-13	2.6e-17	9.3e-21	1.3e-23	5.7e-20
3	TCGA	Breast Invasive Carcinoma	0.0330	0.0125	1.2e-04	0.027	0.018	0.019	NA	0.018	2.8e-06	1.2e-04	5.5e-05	NA	1.1e-04
4	TCGA	Brain Lower Grade Glioma	0.0345	0.0174	8.8e-03	0.034	0.011	0.007	NA	0.023	8.5e-05	1.8e-02	4.3e-02	NA	1.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Heel T-Score	22.5	179.3	289.0	-17.0	-10.4	13.7	-11.5
Heel bone mineral density (BMD) T-score, automated (right)	15.4	35.3	53.4	-6.8	-3.8	7.3	-5.2
Heel bone mineral density (BMD) T-score, automated (left)	13.9	31.4	45.4	-6.3	-3.7	6.7	-5.1
Hair/balding pattern: Pattern 3	6.3	9.4	32.7	-1.2	-1.2	-5.7	-1.4
Hair/balding pattern: Pattern 2	5.8	7.4	28.4	-0.2	-0.6	5.3	0.9
Average weekly spirits intake	5.6	7.0	11.0	3.0	3.3	2.6	1.2
Hearing difficulty/problems: Yes	3.2	4.9	10.4	-1.5	3.2	-1.4	-2.3
Hayfever/allergic rhinitis (self-reported)	3.2	4.2	8.8	-2.7	-0.7	-0.4	-3.0
Wears glasses or contact lenses	3.1	3.6	7.8	-2.8	-0.8	-0.9	-2.2
Commuting to job workplace: Car/motor vehicle	3.0	3.4	10.6	3.3	0.9	-0.0	1.5
Medication: Levothyroxine sodium	2.9	4.9	13.2	2.1	0.3	3.6	1.4
Neuroticism (2016)	2.8	4.0	6.1	0.7	2.1	2.3	2.5
Hip circumference	2.8	12.1	28.3	2.9	3.4	-5.3	0.4
Heart disease (mother)	2.6	3.2	10.9	-1.2	0.7	-0.2	-3.3
Age when periods started (menarche)	2.3	5.6	12.8	-3.6	-1.6	1.4	-2.3
Emphysema/chronic bronchitis	2.3	2.5	5.4	-1.0	2.3	-1.2	-1.6
Major Depression (MDD)	2.1	2.5	7.5	0.1	2.7	1.5	-0.5
Loud music exposure frequency	2.1	2.2	4.5	-2.1	-1.4	-1.5	-0.4
Hearing aid user	2.1	2.4	8.5	0.7	2.9	-0.5	-0.6
Average weekly beer plus cider intake	2.1	3.0	6.9	1.4	0.7	1.6	2.6
Medication: Ramipril	2.0	2.6	6.0	1.9	0.2	2.5	0.7
Leg fat percentage (right)	2.0	7.2	16.3	4.0	2.4	-2.0	1.7
Frequency of depressed mood in last 2 weeks	1.9	2.6	4.0	0.7	2.0	1.6	1.9
Mother’s age at death	1.9	2.3	3.7	-1.9	-1.7	-0.7	-1.6
Medication: Omeprazole (e.g. Zanprol)	1.9	2.4	7.9	1.0	0.6	2.8	0.3
Sitting height	1.8	12.5	32.1	-2.7	1.8	-5.7	-2.6
Pulse rate	1.8	3.1	8.6	-1.6	0.4	-2.9	-0.9
Unable to work because of sickness or disability	1.8	2.3	8.0	1.0	2.8	-0.1	0.5
Lung FEV1/FVC ratio	1.7	8.7	15.6	3.0	-0.4	4.0	3.1
Relative age of first facial hair	1.7	3.4	7.7	-2.4	-0.2	0.3	-2.8
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	10.2	1.4	-0.1	3.2	1.0
Body fat percentage	1.7	6.5	10.7	3.3	2.9	-2.0	1.7
Fasting Glucose	1.6	1.9	4.9	-2.2	-0.7	-0.2	-1.4
Trunk fat percentage	1.6	6.4	11.2	3.0	3.3	-1.7	1.5
Hair/balding pattern: Pattern 4	1.6	4.0	6.4	2.5	1.8	2.2	1.2
Leg fat mass (right)	1.6	6.3	12.0	3.5	2.3	-2.5	1.4
Leg fat percentage (left)	1.6	5.7	12.0	3.5	2.2	-2.0	1.4
Reaction Time	1.5	2.8	7.9	-2.8	1.0	-1.0	-1.1
Medication: Co-codamol	1.5	1.7	4.5	-2.1	-0.6	-1.0	-1.1
Medication: Omeprazole	1.5	1.8	4.2	1.4	0.2	2.0	1.0
Pulse rate, automated reading	1.5	5.0	14.4	-1.7	1.0	-3.8	-1.2
Friendships satisfaction	1.5	1.8	3.2	1.2	0.2	1.8	1.6
Osteoarthritis (self-reported)	1.5	1.9	3.9	1.3	1.2	0.8	2.0
Vascular/heart problems diagnosed by doctor	1.5	4.0	11.9	-0.4	-2.0	-3.4	0.3
Blood White Count	1.4	10.2	17.7	-2.6	1.6	-4.2	-3.7
Supplements: Zinc	1.4	1.5	3.4	0.3	1.8	1.6	-0.4
Had other major operations	1.4	1.7	5.4	0.3	0.6	-2.3	1.0
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	5.1	2.2	1.0	0.4	0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	3.5	0.2	0.8	1.9	-1.3
Commuting to job workplace: Walk	1.4	1.5	5.0	-2.2	-0.0	-0.5	-0.9
Average weekly champagne plus white wine intake	1.4	2.0	6.7	-0.8	0.2	-2.6	-0.7
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.6	-1.9	-1.6	0.3	-0.3
Leg fat mass (left)	1.4	5.5	9.9	3.1	2.1	-2.5	1.1
HDL Cholesterol	1.3	2.2	7.0	1.3	0.1	0.3	2.6
Height	1.3	25.8	84.1	-2.0	2.5	-9.2	-2.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.8	4.3	0.4	2.1	-0.3	1.6
Relative age voice broke	1.3	2.0	4.1	-2.0	-0.3	1.0	-1.6
Trunk fat mass	1.3	5.8	8.4	2.5	2.8	-2.9	0.9
Breastfed as a baby	1.3	1.7	3.4	0.7	-1.8	1.4	1.0
Medication: Seretide 50 evohaler	1.3	1.5	4.8	-0.4	0.9	-2.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	6.0	-0.7	2.0	-2.4	0.3
Handedness (chirality/laterality): Left-handed	1.3	1.6	3.1	-1.7	-0.9	-1.5	-0.4
Back pain experienced in last month	1.3	1.8	4.0	-1.1	1.0	-1.1	-2.0
Bipolar Disorder (2011)	1.2	1.2	3.4	-1.8	0.0	0.5	-1.0
LDL Cholesterol	1.2	1.9	2.9	1.7	-1.3	1.3	1.1
Hypothyroidism (self reported)	1.2	2.7	8.3	1.2	-0.3	2.9	1.1
Diabetes (father)	1.2	1.5	3.0	-0.4	-0.1	1.7	-1.7
Diabetes (mother)	1.2	1.6	2.5	-1.6	-1.5	-1.0	-0.7
Number of incorrect matches in round	1.2	2.0	3.5	1.1	-1.9	1.4	1.1
Nervous feelings	1.2	2.2	8.0	0.7	2.8	0.3	0.5
Pain all over the body in last month	1.2	1.3	2.8	1.1	0.4	1.1	1.7
Medication: Simvastatin	1.2	1.8	5.2	2.3	0.2	0.4	1.4
Standing height	1.2	12.3	37.1	-1.6	2.1	-6.1	-2.3
Whole body fat mass	1.2	5.2	7.3	2.7	2.3	-2.6	1.1
Guilty feelings	1.2	1.8	5.5	-0.8	0.1	2.3	1.0
Alzheimer’s Disease (in father)	1.1	1.2	4.5	0.3	0.0	-2.1	0.2
High blood pressure	1.1	3.2	11.0	0.1	1.3	3.3	0.1
Lung cancer (father)	1.1	1.3	2.4	-0.9	-1.5	-0.3	-1.5
High blood pressure (siblings)	1.1	1.6	2.6	-1.0	-0.9	1.6	-1.4
Knee pain experienced in last month	1.1	1.8	3.3	1.3	1.8	-1.2	0.7
Illnesses of siblings: Diabetes	1.1	1.3	2.8	-1.3	-0.9	0.1	-1.7
Arm fat percentage (left)	1.1	4.2	7.8	2.8	2.2	-1.0	1.8
Mood swings	1.1	2.0	7.0	-0.8	0.0	2.7	0.7
Tinnitus: Yes, now most or all of the time	1.1	1.2	3.9	-2.0	-0.2	-0.3	-0.9
Heart disease (siblings)	1.1	1.4	4.4	2.1	-0.1	1.1	0.2
Supplements: Glucosamine	1.0	1.3	3.8	-0.6	0.0	-1.0	-1.9
Forced vital capacity (FVC)	1.0	3.7	5.8	-2.3	1.2	-2.4	-1.6
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	3.1	-0.4	-0.9	1.8	-1.0
Heart attack	1.0	1.2	3.4	0.9	1.9	0.7	0.6
Arm fat percentage (right)	1.0	3.9	6.5	2.5	2.4	-1.2	1.4
Alcohol intake versus 10 years previously	1.0	1.5	3.0	1.7	-1.5	0.5	0.8
Pulse wave reflection index	1.0	1.2	3.4	1.2	0.2	1.8	0.2
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.9	0.2	0.2	-2.0	-1.0
Chronic bronchitis/emphysema (mother)	1.0	1.1	3.1	0.1	-0.4	-1.8	1.1
Medication for pain relief, constipation, heartburn	1.0	1.8	3.7	-1.3	-0.0	-1.9	-1.3
Migraine (self-reported)	1.0	1.2	3.7	-1.0	-0.4	-1.9	0.0
Age at last live birth	1.0	1.5	5.8	0.3	2.4	0.2	0.2
Medication: Aspirin	1.0	1.3	2.7	1.7	0.9	1.1	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.0	1.7	-0.4	0.8	1.0
Mineral and other dietary supplements	1.0	1.3	2.2	-0.5	-1.5	-1.5	0.7
Commuting to job workplace: Public transport	1.0	1.2	1.5	-1.2	-1.1	-0.8	-1.2
Medication: Blood pressure	1.0	1.8	5.6	0.6	1.1	2.4	0.5
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.3	0.9	1.8	0.7	0.6
Ulcerative Colitis	0.9	1.3	1.6	-1.0	-1.3	1.0	-1.2
Waist Hip Ratio (WHR)	0.9	3.8	11.2	0.5	-1.9	3.4	0.3
Lung FVC	0.9	4.7	12.1	-3.5	-1.1	-0.6	-2.3
Systolic blood pressure, automated reading	0.9	2.6	6.2	-1.4	-2.5	-0.4	-1.4
Angina	0.9	1.1	1.5	-1.0	1.1	0.9	-1.2
Impedance of leg (right)	0.9	4.1	9.8	2.1	3.1	0.1	1.5
Average weekly fortified wine intake	0.9	1.0	2.4	0.1	1.1	-1.6	-0.7
Waist circumference	0.9	3.3	6.4	2.3	1.2	-2.5	0.1
Hearing difficulty/problems with background noise	0.9	1.5	3.3	-1.1	0.8	0.9	-1.8
Weight	0.9	4.2	12.2	1.6	1.4	-3.5	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	5.8	0.1	2.4	0.6	-0.1
Forced vital capacity (FVC), Best measure	0.9	3.3	4.8	-2.2	1.2	-2.2	-1.5
Hypertension (Self-reported)	0.9	2.5	9.4	0.1	0.8	3.1	-0.2
Medication: Atorvastatin	0.9	1.2	2.0	-1.4	-0.9	1.0	-0.9
Rheumatoid Arthritis	0.8	1.1	3.1	1.0	1.8	-0.7	0.1
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.6	-1.1	-0.7	1.3	-0.6
Allergy or Eczema	0.8	2.2	6.8	-1.0	-1.0	0.3	-2.6
High blood pressure (mother)	0.8	1.1	3.2	0.5	1.8	0.9	-0.1
Time employed in main current job	0.8	0.9	2.6	1.6	0.5	-0.8	0.0
Father’s age at death	0.8	1.0	4.0	0.2	2.0	-0.2	-0.3
Depression (self-reported)	0.8	0.9	2.1	-0.4	1.4	0.7	-1.0
Prospective memory result	0.8	0.9	2.7	-0.8	-0.5	-1.6	0.2
Arm fat mass (right)	0.8	3.5	5.6	2.4	2.0	-1.8	0.9
Glaucoma (self-reported)	0.8	0.9	2.1	-1.4	-0.8	-0.2	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.8	0.9	0.5	0.9	1.4
Comparative height size at age 10	0.8	4.6	12.5	0.8	2.2	-3.5	-0.5
Had major operations	0.8	1.0	2.3	0.7	1.5	1.0	-0.4
Medication for cholesterol	0.8	1.1	2.9	-0.1	1.2	-1.7	0.4
Osteoporosis (self-reported)	0.8	0.9	2.7	-0.8	-1.6	0.6	-0.1
Arm fat mass (left)	0.8	3.2	6.2	2.5	1.9	-1.4	1.1
Illnesses of father: High blood pressure	0.8	1.0	2.2	0.3	1.1	1.5	-0.7
Commuting to job workplace: Cycle	0.8	0.9	2.4	-1.6	0.7	0.8	-0.5
Myopia	0.8	1.2	3.7	0.4	-0.9	-1.9	0.2
Depression (Nagel 2018)	0.7	1.1	2.9	-0.8	1.7	-0.3	0.9
Ulcerative Colitis (UC)	0.7	1.2	3.4	-0.7	-1.8	0.5	-0.9
Body Mass Index (BMI) (2010)	0.7	1.0	1.7	1.3	-0.7	-0.2	1.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.6	-1.3	-1.0	0.9	-0.0
Medication for hormone replacement therapy	0.7	0.7	1.7	-0.3	-0.9	1.3	-0.5
Impedance of arm (right)	0.7	3.4	13.1	-0.3	3.6	-0.6	0.4
Trunk fat-free mass	0.7	4.3	12.8	-0.8	-0.4	-3.6	-1.9
Impedance of arm (left)	0.7	3.3	11.3	0.3	3.4	0.1	1.3
Trunk predicted mass	0.7	4.0	11.8	-0.9	-0.4	-3.4	-1.8
Exposure to tobacco smoke at home	0.7	0.8	1.6	1.3	-0.7	0.3	1.1
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.3	0.0	-0.4	-0.4	1.8
Medication: Blood pressure	0.7	1.3	4.2	0.1	-0.6	2.0	-0.7
Angina (self-reported)	0.7	0.9	1.2	-1.0	1.1	0.8	-0.9
Mean time to correctly identify matches	0.7	1.4	4.2	-2.1	0.9	-0.6	-0.4
Supplements: Vitamin C	0.7	0.8	2.1	1.0	0.2	-1.4	-0.5
Illnesses of father: Heart disease	0.7	0.9	2.3	-0.5	-1.5	1.0	0.0
Smoking status: Previous	0.7	1.1	4.0	0.4	-0.1	2.0	-0.6
Long-standing illness, disability or infirmity	0.7	1.0	2.6	-0.9	-0.5	0.7	-1.6
Diabetes diagnosed by doctor	0.7	1.2	3.5	-0.5	-1.0	1.9	-0.0
Medication: Aspirin	0.7	0.9	1.5	1.2	0.8	1.0	0.6
Illnesses of father: None of the above (group 1)	0.7	0.9	1.7	0.5	0.8	-1.0	1.3
Number of self-reported non-cancer illnesses	0.7	1.2	3.4	1.0	0.6	1.9	-0.3
Eye problems/disorders: Glaucoma	0.7	0.8	3.0	-1.7	-0.3	0.2	-0.2
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.3	0.4	0.6	1.5	-0.8
High cholesterol (Self-reported)	0.7	1.2	2.8	1.7	-0.3	1.3	0.5
Ever depressed for a whole week	0.7	0.9	1.7	-1.2	1.3	0.5	-0.5
Basal cell carcinoma (self-reported)	0.7	0.8	1.1	0.7	1.1	-0.9	0.9
Impedance of whole body	0.7	3.8	12.7	0.9	3.6	0.2	1.3
Breast Cancer	0.6	1.5	3.3	0.6	-1.2	1.8	0.9
Coronary Artery Disease (CAD)	0.6	0.7	1.8	-0.6	0.2	0.9	-1.3
Systolic Blood Pressure	0.6	3.0	4.5	-2.1	-1.9	1.2	-1.6
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.2	0.8	1.5	-0.3	-0.5
Maternal smoking around birth	0.6	0.9	1.7	-0.4	-1.0	-0.8	1.3
Hayfever, allergic rhinitis or eczema	0.6	1.3	4.3	-0.9	0.3	-0.4	-2.1
Impedance of leg (left)	0.6	2.7	7.8	1.5	2.8	-0.1	1.0
Past tobacco smoking	0.6	1.0	3.8	-0.2	-0.1	-2.0	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.5	0.5	1.2	1.2	0.8
Had menopause	0.6	0.7	1.2	-0.8	-0.6	-0.7	-1.1
Financial difficulties in last 2 years	0.6	0.8	2.9	0.4	-0.1	1.7	0.4
Illnesses of siblings	0.6	0.9	1.6	0.6	1.1	-0.7	1.3
Neuroticism score	0.6	1.2	3.7	-1.9	0.5	0.8	-0.2
Falls in the last year	0.6	0.7	1.6	-0.8	1.3	-0.7	0.4
Happiness	0.6	0.7	2.1	0.1	0.6	1.4	0.5
Length of working week for main job	0.6	0.7	1.4	-0.8	-0.5	-0.6	-1.2
Exposure to tobacco smoke outside home	0.6	0.9	1.9	1.4	-1.1	0.5	0.1
Worry too long after embarrassment	0.6	1.0	2.1	-1.5	0.9	1.1	0.0
Pulse wave peak to peak time	0.6	0.7	1.8	-0.2	0.9	-1.3	-0.3
Whole body fat-free mass	0.6	3.5	11.6	-0.4	0.1	-3.4	-1.5
Eye problems/disorders: Cataract	0.6	0.6	1.2	-0.5	0.9	0.6	-1.1
Whole body water mass	0.6	3.5	11.9	-0.4	-0.0	-3.5	-1.4
Ever taken oral contraceptive pill	0.6	0.7	2.0	-0.7	0.3	-0.6	-1.4
Basal metabolic rate	0.6	3.2	11.3	0.3	0.6	-3.4	-1.1
Cholesterol lowering medication	0.6	0.9	1.3	0.8	-1.1	1.1	0.5
Pack years of smoking	0.6	0.9	1.5	-0.8	-1.2	-0.7	-1.0
Schizophrenia (2018)	0.5	1.0	2.4	1.1	0.8	1.5	-0.1
Alzheimer’s Disease (including proxy)	0.5	0.7	2.5	-0.4	-0.0	-1.6	0.5
Number of treatments/medications taken	0.5	1.0	3.1	-0.1	0.5	1.8	-0.7
Vitamin and mineral supplements	0.5	0.7	1.3	-1.1	-0.9	-0.8	-0.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.7	-0.6	0.0	-1.3	-0.4
Qualifications: CSEs or equivalent	0.5	0.7	1.4	1.2	0.6	0.7	0.6
Serious illness, injury or assault to yourself	0.5	0.6	1.6	-0.5	1.3	0.7	-0.3
Medication: Atenolol	0.5	0.6	2.2	-1.5	-0.3	-0.1	-0.5
Body mass index (BMI)	0.5	2.1	6.6	2.6	0.6	-0.7	1.0
Allergy	0.5	1.1	2.9	1.3	-0.1	0.1	1.7
Diabetes (self-reported)	0.5	0.7	1.9	-0.3	-0.9	1.4	0.3
Noisy workplace	0.5	0.7	2.0	-0.2	0.4	0.6	-1.4
Medication: Lansoprazole	0.5	0.5	1.4	0.3	0.9	-0.0	-1.2
Pulse wave Arterial Stiffness index	0.5	0.6	1.2	0.1	-1.0	1.1	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.7	-0.2	-0.2	1.6	-0.1
Headache pain in last month	0.5	0.8	1.4	-0.1	-1.2	-1.2	0.6
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.7	0.2	0.5	-1.6	0.4
Medication: Amlodipine	0.5	0.7	2.5	0.0	-0.4	1.6	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.6	-0.2	0.4	1.3	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.8	-0.2	0.6	0.3	-1.3
Eye problems/disorders: None of the above	0.5	0.5	0.8	0.7	-0.8	-0.9	-0.4
Number of full sisters	0.5	0.6	2.2	0.0	-0.6	1.5	0.1
Leg fat-free mass (right)	0.5	2.4	8.0	-0.4	0.3	-2.8	-1.2
Medication: Gliclazide	0.5	0.5	1.7	-0.3	-1.3	-0.4	0.5
Miserableness	0.5	0.9	2.5	0.3	1.0	0.2	1.6
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.3	-1.2	0.4	-0.3	-0.8
Medication: Bendroflumethiazide	0.5	0.8	1.3	-0.6	1.2	0.9	-0.6
Arm fat-free mass (left)	0.5	2.5	8.8	0.2	0.1	-3.0	-1.1
Number of operations (self-reported)	0.5	0.8	1.4	0.8	0.9	1.2	0.4
Arm predicted mass (left)	0.5	2.5	8.6	0.1	-0.1	-2.9	-1.2
Bipolar Disorder or Schizophrenia	0.4	0.9	2.6	0.5	0.8	1.6	0.6
Schizophrenia vs Biploar Disorder	0.4	0.6	1.7	1.3	-0.2	-0.4	0.6
Ovarian Cancer	0.4	0.5	1.4	-0.1	-0.7	-1.2	-0.1
Primary Biliary Cirrhosis	0.4	0.6	1.2	-1.1	-0.3	0.6	-0.8
Triglycerides	0.4	0.7	1.6	-0.4	-0.5	1.3	-0.9
BMI	0.4	2.2	4.9	2.2	1.6	-0.6	1.0
Cardiovascular Disease	0.4	1.2	4.4	0.0	0.5	2.1	-0.3
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.6	-0.3	-1.3	0.9	-0.5
Leg fat-free mass (left)	0.4	2.3	7.9	0.4	0.9	-2.8	-0.6
Townsend deprivation index at recruitment	0.4	0.6	2.0	-0.1	-0.0	1.4	-0.7
Leg predicted mass (left)	0.4	2.3	8.1	0.4	0.8	-2.8	-0.7
Worrier / anxious feelings	0.4	0.7	2.2	-1.5	0.1	-0.7	-0.3
Mouth/teeth dental problems: Dentures	0.4	0.6	1.4	-0.8	-1.2	-0.1	-0.7
Medication: Cholesterol lowering	0.4	0.7	1.6	1.3	0.5	0.7	0.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.5	1.2	1.0	-0.0	-0.2
Birth weight	0.4	0.9	2.9	-1.7	-0.3	0.6	-0.4
Arm fat-free mass (right)	0.4	1.9	6.6	0.5	-0.4	-2.6	-0.8
Age at first live birth	0.4	0.7	1.5	0.9	1.2	0.2	-0.6
Overall health rating	0.4	0.9	2.3	-0.3	1.5	1.0	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	0.8	1.0	0.6	0.1
Loneliness, isolation	0.4	0.6	1.7	0.1	0.7	1.3	0.2
Leg predicted mass (right)	0.4	2.2	7.5	-0.3	0.3	-2.7	-1.1
Medication: Lisinopril	0.4	0.6	1.3	0.2	0.4	1.1	0.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.3	0.2	-1.1	0.1	0.8
Bipolar Disorder (2018)	0.3	0.5	1.1	-0.5	0.3	0.6	1.0
Neuroticism (Nagel 2018)	0.3	0.7	1.5	-1.2	0.3	1.0	0.3
Alzheimer’s Disease (in mother)	0.3	0.4	0.8	-0.8	-0.2	-0.9	0.1
Neuroticism	0.3	0.7	2.2	-1.5	0.2	0.7	-0.1
Sensitivity / hurt feelings	0.3	0.6	1.2	-1.1	0.5	1.0	0.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	0.8	-0.5	-0.2	0.6
Multivitamins +/- minerals	0.3	0.4	1.3	-0.4	1.2	-0.1	-0.5
Alcohol usually taken with meals	0.3	0.6	2.0	-0.4	0.2	-1.4	0.2
Qualifications: None of the above	0.3	0.6	2.0	-1.4	-0.6	0.3	-0.1
Fluid intelligence score	0.3	0.6	0.9	-0.9	0.5	-0.7	-0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.2	-1.1	-0.0	-0.5	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.6	-0.1	-0.5	-0.7	-0.7
Illnesses of mother	0.3	0.4	0.6	0.7	-0.5	-0.3	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.2	-1.0	1.1	-1.1	-0.5
Blood clot in the leg (DVT)	0.3	0.4	1.2	0.1	-1.1	0.1	0.7
Medication: Paracetamol	0.3	0.5	1.6	0.6	0.2	-0.0	1.3
Gout (self-reported)	0.3	0.4	1.1	1.1	-0.1	0.7	0.3
Wheeze or whistling in the chest in last year	0.3	0.5	0.9	-1.0	0.1	-0.6	-0.9
Shortness of breath walking on level ground	0.3	0.3	1.0	0.3	-0.2	1.0	0.3
Qualifications: College or University degree	0.3	1.0	3.1	-1.8	-0.3	0.8	-0.1
Arm predicted mass (right)	0.3	1.5	4.8	0.7	-0.3	-2.2	-0.7
Leg pain on walking	0.3	0.4	1.1	1.0	0.6	-0.5	0.1
Average weekly red wine intake	0.3	0.4	1.0	0.7	1.0	-0.3	-0.1
Ever had bowel cancer screening	0.3	0.3	0.6	0.7	-0.0	0.2	-0.8
Qualifications: nursing, teaching	0.3	0.5	1.1	1.1	0.8	-0.3	0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.0	0.5	0.1	0.6	1.0
Risk taking	0.3	0.4	0.8	0.9	-0.9	-0.1	0.3
Age started oral contraceptive pill	0.3	0.4	0.7	0.8	-0.2	-0.6	0.8
Alcohol drinker status: Previous	0.3	0.3	1.0	-0.4	0.4	1.0	0.3
Worry (Nagel 2018)	0.2	0.3	0.7	-0.8	0.6	-0.5	0.1
Crohns Disease (2017)	0.2	0.4	1.5	-0.1	0.2	-1.2	-0.3
Irritable Bowel Disease (IBD)	0.2	0.6	1.9	-0.5	-1.4	-0.1	-0.4
Age at First Birth	0.2	0.4	0.8	0.3	-0.1	-0.7	0.9
Mean Putamen Volume	0.2	0.2	0.3	0.4	0.4	-0.5	0.5
Lupus	0.2	0.3	0.9	0.2	1.0	-0.2	0.4
Schizophrenia (2014)	0.2	0.5	2.0	0.3	0.0	1.4	-0.3
Chronotype (morning person)	0.2	0.6	1.9	0.4	-0.1	-1.4	-0.5
Hand grip strength (left)	0.2	0.6	0.9	-0.7	-0.6	-0.9	-0.9
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.7	0.8	0.7	0.3	-0.2
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	0.1	0.2	0.9	-0.1
Medication: Metformin	0.2	0.3	0.4	-0.1	-0.5	0.7	0.6
Severe depression (siblings)	0.2	0.2	0.6	-0.8	0.1	0.1	0.5
Pack years adult smoking proportion	0.2	0.4	0.6	-0.3	-0.8	-0.7	-0.6
Current tobacco smoking	0.2	0.4	0.6	-0.6	-0.3	-0.7	0.8
Taking other prescription medications	0.2	0.4	0.7	0.7	0.6	0.8	-0.1
Stomach or abdominal pain in last month	0.2	0.2	0.3	0.4	0.5	0.4	-0.4
Mouth/teeth dental problems	0.2	0.3	0.9	-1.0	-0.1	0.3	-0.3
Number of live births	0.2	0.3	0.7	-0.8	0.3	0.5	-0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.6	-0.8	0.8	-1.3	-0.3
Asthma	0.2	0.4	0.6	-0.7	-0.7	0.8	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.0	-0.3	-0.0	-0.3	1.0
Tense / ‘highly strung’	0.2	0.3	1.1	-0.3	0.0	0.0	1.0
Birth weight of first child	0.2	0.3	1.0	-0.0	0.2	1.0	0.4
Peak expiratory flow (PEF)	0.2	0.5	1.2	-1.1	-0.7	-0.6	-0.3
Number of full brothers	0.2	0.3	0.6	-0.7	-0.1	0.8	-0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	0.6	0.5	-0.2	0.4
Medication: Allopurinol	0.2	0.3	0.5	-0.7	-0.4	0.2	-0.6
Suffer from ‘nerves’	0.2	0.4	1.3	-1.1	0.2	-0.3	0.2
Chest pain or discomfort	0.2	0.3	0.7	0.0	0.8	0.8	-0.2
Family relationship satisfaction	0.2	0.3	0.7	0.5	0.3	0.8	0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	0.4	-0.4	-0.5	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	-0.2	0.3	0.7	0.4
Smoking status: Current	0.2	0.3	1.0	-0.2	-0.2	-0.3	1.0
Ever smoked	0.2	0.3	0.6	-0.7	0.4	0.7	0.1
Fractured/broken bones in last 5 years	0.2	0.2	0.4	-0.2	0.6	-0.0	0.7
Pain experienced in last month	0.2	0.3	0.8	-0.2	-0.6	0.9	-0.5
Depressed Affect (Nagel 2018)	0.1	0.3	0.8	-0.9	0.4	0.3	0.4
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.8	-0.7	0.2	-0.1	-0.9
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.5	0.5	0.0	0.3
Crohns Disease (2012)	0.1	0.2	0.4	0.4	0.3	-0.6	-0.1
Blood Eosinophil Count	0.1	0.6	1.0	0.8	-1.0	0.8	0.1
Blood Platelet Count	0.1	1.2	3.6	0.8	1.9	0.0	0.5
Blood Red Count	0.1	0.5	1.1	0.1	-1.1	-0.1	-1.0
Tanning	0.1	0.7	1.6	-1.0	-0.5	-1.2	0.3
Hand grip strength (right)	0.1	0.1	0.5	0.1	-0.7	-0.2	-0.2
Fed-up feelings	0.1	0.2	0.6	-0.5	0.8	0.2	0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.6	-0.8	-0.2	0.1	0.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	0.5	-0.2	-0.4	-0.0
Comparative body size at age 10	0.1	0.4	1.2	1.1	0.5	-0.4	0.1
Number of children fathered	0.1	0.1	0.4	0.4	-0.1	-0.6	0.1
Health satisfaction	0.1	0.1	0.2	0.2	0.2	0.5	0.3
Neck or shoulder pain in last month	0.1	0.1	0.3	-0.6	0.3	-0.0	0.1
Medication: Ibuprofen	0.1	0.2	0.3	-0.6	0.1	-0.5	-0.2
Alcohol intake frequency.	0.1	0.2	0.8	0.4	0.1	0.9	-0.0
Breast cancer (self-reported)	0.1	0.1	0.3	0.4	0.6	0.3	-0.2
Asthma (self-reported)	0.1	0.1	0.4	-0.2	-0.6	0.2	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.6	-0.2	-0.5	-0.8	0.4
Financial situation satisfaction	0.1	0.1	0.2	-0.4	-0.3	0.5	-0.4
Medication: Paracetamol	0.1	0.2	0.2	0.2	0.5	-0.3	0.5
Alcohol drinker status: Never	0.1	0.2	0.4	-0.3	0.6	0.3	0.3
Irritability	0.1	0.1	0.5	-0.1	0.2	0.7	-0.1
Diastolic blood pressure, automated reading	0.1	0.4	1.5	0.3	-0.4	-1.2	0.1
Supplements: Calcium	0.1	0.1	0.3	0.1	0.6	0.0	-0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HbA1C	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1
Smoking Status	0.0	0.0	0.1	0.1	0.0	0.3	0.3
Respiratory disease	0.0	0.1	0.2	-0.2	-0.0	0.4	-0.3
Hair Pigment	0.0	1.1	2.0	0.2	1.4	-1.4	0.5

Hub : Genes

EYA4

Models

Trait associations