Best TWAS P=2.84e-93 · Best GWAS P=4.67e-76 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ESR1 | 0.19 | 0.10 | enet | 36 | 0.10 | 2.2e-12 | 11.7 | -9.0 | 2.4e-19 | -0.03 | 1.00 | 0.00 | TRUE |
2 | METSIM | Adipose | CCDC170 | 0.14 | 0.02 | blup | 621 | 0.07 | 6.1e-11 | -1.9 | -9.8 | 1.1e-22 | 0.35 | 0.99 | 0.00 | FALSE |
3 | ROSMAP | Brain Pre-frontal Cortex | CCDC170 | 0.20 | 0.06 | lasso | 10 | 0.19 | 7.2e-24 | -5.9 | -6.0 | 1.5e-09 | 0.53 | 0.11 | 0.89 | TRUE |
4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C6orf97 | 0.05 | 0.00 | blup | 133 | 0.03 | 1.3e-03 | -18.4 | -18.4 | 2.6e-75 | 0.80 | 0.01 | 0.87 | FALSE |
5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C6orf97 | 0.01 | 0.01 | enet | 7 | 0.01 | 5.3e-03 | -9.6 | -17.3 | 4.4e-67 | 0.82 | 0.01 | 0.94 | FALSE |
6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C6orf97 | 0.08 | 0.02 | blup | 133 | 0.07 | 6.2e-08 | -10.2 | -14.1 | 5.3e-45 | 0.68 | 0.02 | 0.98 | TRUE |
7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C6orf97 | 0.06 | 0.05 | lasso | 3 | 0.08 | 6.9e-09 | -10.9 | -12.8 | 1.5e-37 | 0.58 | 0.22 | 0.76 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C6orf97 | 0.18 | 0.06 | lasso | 4 | 0.05 | 1.1e-03 | -5.9 | -7.4 | 1.2e-13 | 0.49 | 0.33 | 0.32 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C6orf97 | 0.08 | 0.04 | blup | 133 | 0.09 | 1.2e-10 | -18.4 | -15.7 | 2.1e-55 | 0.78 | 0.00 | 1.00 | TRUE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RMND1 | 0.11 | 0.01 | blup | 57 | 0.04 | 1.5e-05 | 2.9 | 5.3 | 1.2e-07 | 0.03 | 0.56 | 0.01 | FALSE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | C6orf97 | 0.07 | 0.03 | lasso | 5 | 0.05 | 1.7e-06 | -5.9 | -13.3 | 3.9e-40 | 0.71 | 0.01 | 0.97 | TRUE |
12 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C6orf97 | 0.14 | 0.01 | blup | 133 | 0.08 | 5.2e-06 | -18.4 | -12.8 | 2.6e-37 | 0.74 | 0.00 | 0.94 | FALSE |
13 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C6orf97 | 0.23 | 0.10 | lasso | 11 | 0.11 | 1.8e-05 | -18.4 | -20.5 | 2.8e-93 | 0.87 | 0.00 | 0.99 | TRUE |
14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C6orf97 | 0.10 | 0.05 | blup | 133 | 0.06 | 2.6e-07 | -18.4 | -11.6 | 3.3e-31 | 0.72 | 0.00 | 1.00 | FALSE |
15 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C6orf97 | 0.13 | 0.02 | blup | 133 | 0.05 | 2.8e-04 | -10.2 | -12.1 | 1.9e-33 | 0.63 | 0.01 | 0.90 | TRUE |
16 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RMND1 | 0.19 | 0.06 | blup | 58 | 0.10 | 1.6e-04 | -4.6 | 5.9 | 4.1e-09 | 0.10 | 0.15 | 0.14 | TRUE |
17 | The Cancer Genome Atlas | Thyroid Carcinoma | C6orf97 | 0.08 | 0.02 | lasso | 4 | 0.06 | 3.4e-06 | -17.6 | -15.6 | 1.3e-54 | 0.85 | 0.01 | 0.98 | FALSE |