TWAS hub - CRTC3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.0800	0.0350	3.0e-03	0.073	NA	0.044	NA	0.027	1.2e-05	NA	0.00061	NA	6.6e-03
2	GTEx	Nerve Tibial	0.1087	0.0386	1.6e-03	-0.001	NA	0.020	NA	0.022	4.1e-01	NA	0.01400	NA	9.9e-03
3	GTEx	Skin Sun Exposed Lower leg	0.0990	0.0340	1.0e-04	0.081	NA	0.022	NA	0.048	3.2e-07	NA	0.00580	NA	7.5e-05
4	YFS	Blood	0.0212	0.0078	5.9e-05	0.010	0.012	0.009	0.012	0.011	2.4e-04	4.2e-05	0.00051	7e-05	1.1e-04
5	TCGA	Colon Adenocarcinoma	0.0720	0.0350	2.3e-03	0.020	0.027	0.002	NA	0.009	2.4e-02	9.9e-03	0.23000	NA	9.8e-02
6	TCGA	Brain Lower Grade Glioma	0.0333	0.0210	6.2e-03	0.008	0.008	0.000	NA	0.004	3.4e-02	4.2e-02	0.30000	NA	1.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Heel T-Score	14.0	111.2	174.2	12.4	8.2	13.2	11.1	5.9	10.7
Allergy or Eczema	13.7	36.1	63.1	7.9	-2.1	7.3	7.6	0.4	6.1
Hayfever, allergic rhinitis or eczema	13.6	29.6	51.3	7.2	-2.5	6.6	6.9	0.5	5.3
Hair/balding pattern: Pattern 4	11.7	28.3	51.4	5.8	1.2	7.2	6.6	0.4	6.3
Heel bone mineral density (BMD) T-score, automated (left)	8.9	20.2	34.2	5.5	2.5	5.8	4.8	2.7	4.4
Heel bone mineral density (BMD) T-score, automated (right)	8.1	18.5	29.0	5.0	3.1	5.4	4.3	2.8	4.5
Hayfever/allergic rhinitis (self-reported)	7.0	9.3	16.4	3.8	-1.4	3.6	4.0	0.3	3.2
Allergy	6.5	15.0	24.2	-4.9	2.9	-4.5	-4.8	-0.2	-3.7
Supplements: Calcium	5.0	5.5	8.5	-2.9	-0.3	-2.9	-2.7	-0.7	-2.9
Comparative height size at age 10	4.9	26.9	48.2	-6.2	-2.7	-6.9	-6.0	-2.1	-5.2
Pain all over the body in last month	4.3	4.6	9.7	2.4	0.3	2.4	2.4	-0.8	3.1
Mouth/teeth dental problems: Mouth ulcers	4.2	6.7	11.5	3.1	0.7	3.1	3.4	0.2	3.1
Birth weight of first child	4.1	7.4	15.8	4.0	0.8	3.2	2.1	0.2	3.6
Tinnitus: Yes, but not now, but have in the past	3.2	3.4	14.3	1.4	-1.0	0.8	0.9	3.8	-1.4
Supplements: Zinc	3.1	3.4	4.7	-2.0	-1.6	-1.9	-2.2	-0.7	-2.2
Ever had hysterectomy (womb removed)	2.9	3.3	6.9	-2.6	-0.9	-2.0	-2.0	-1.1	-1.8
Verbal and Numeric Reasoning (VNR)	2.8	6.8	10.4	3.1	1.9	3.2	2.8	2.2	2.1
Emphysema/chronic bronchitis	2.8	3.2	6.4	-1.7	-0.2	-2.3	-2.5	0.3	-2.1
Fractured/broken bones in last 5 years	2.8	3.6	5.7	-2.1	-0.9	-2.2	-1.9	-1.6	-2.4
Pack years of smoking	2.7	3.9	6.8	-2.6	-1.0	-2.4	-2.2	-0.8	-2.1
Had major operations	2.6	3.1	7.7	-1.7	-1.0	-2.3	-1.4	-2.8	0.1
Forced expiratory volume in 1-second (FEV1), predicted	2.6	5.5	9.8	-2.9	-0.8	-2.7	-3.1	-1.7	-2.1
Vitamin and mineral supplements	2.5	3.4	9.6	2.2	0.9	1.5	1.3	-0.9	3.1
Standing height	2.5	24.3	38.3	-5.7	-3.7	-6.2	-5.0	-1.1	-5.9
Falls in the last year	2.4	3.2	6.4	2.5	0.7	2.2	2.2	1.5	0.6
Eye problems/disorders: Diabetes related eye disease	2.3	2.6	3.9	1.8	1.6	1.4	2.0	0.4	1.9
Mouth/teeth dental problems: Loose teeth	2.3	2.7	6.6	1.4	0.3	2.6	1.8	0.6	1.9
Illnesses of father: High blood pressure	2.3	2.9	4.6	0.8	2.0	2.1	1.8	-0.2	2.2
Number of incorrect matches in round	2.2	3.7	6.5	-2.1	-2.6	-2.0	-1.3	-2.3	-0.6
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.5	5.2	1.8	-0.3	2.1	2.3	0.6	1.2
Osteoporosis (self-reported)	2.2	2.8	3.9	-1.8	-1.5	-1.9	-2.0	-1.9	-0.2
Financial situation satisfaction	2.2	2.7	6.1	-2.5	-1.2	-1.9	-1.7	-1.0	-1.1
Pack years adult smoking proportion	2.1	3.2	5.5	-2.4	-0.5	-2.2	-2.0	-0.4	-2.1
Illnesses of father: Heart disease	2.1	2.9	5.2	1.1	-1.5	2.2	2.3	-0.5	1.8
Schizophrenia (2018)	2.0	4.2	7.3	-1.2	-2.5	-2.5	-2.0	0.1	-2.7
Ulcerative Colitis (UC)	2.0	3.7	10.8	-2.1	0.8	-0.8	-2.0	-3.3	1.1
Breast Cancer	2.0	4.9	10.5	2.3	0.8	2.9	3.2	1.1	1.8
Mouth/teeth dental problems	2.0	3.1	5.7	-1.9	1.3	-2.4	-2.4	0.1	-1.3
Migraine (self-reported)	2.0	2.5	5.1	-1.9	-1.0	-1.9	-1.2	-0.5	-2.3
Height	1.9	37.3	66.3	-7.2	-3.4	-8.1	-6.8	-1.9	-6.7
Hand grip strength (right)	1.9	5.2	9.2	-2.5	1.3	-3.0	-2.5	0.2	-2.7
Bilateral oophorectomy (both ovaries removed)	1.9	2.1	4.2	-2.1	-0.8	-1.8	-1.3	-1.3	-1.2
Chest pain or discomfort	1.9	2.7	6.9	1.9	-0.1	1.9	2.6	1.4	0.5
Medication: Gliclazide	1.9	2.1	6.9	0.6	2.6	0.9	-0.6	-1.0	1.8
Tinnitus: Yes, now most or all of the time	1.9	2.3	4.6	-1.6	-1.5	-1.6	-1.2	-2.1	-0.6
Fluid intelligence score	1.8	3.8	7.6	1.7	2.4	2.1	1.3	0.6	2.8
Exposure to tobacco smoke at home	1.8	2.1	2.8	-1.7	-1.6	-1.3	-1.3	-1.7	-0.9
Pulse wave reflection index	1.8	2.2	4.5	1.6	1.7	1.1	1.3	2.1	0.4
Family relationship satisfaction	1.8	2.3	4.7	-1.7	-0.5	-1.4	-1.6	-2.2	-1.0
Illnesses of siblings: Diabetes	1.8	2.2	4.2	-1.4	-1.4	-2.0	-1.1	-1.7	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	6.2	-1.1	-2.5	-0.8	-0.3	-1.7	-0.5
Rheumatoid Arthritis	1.7	2.3	5.2	-1.8	0.0	-1.6	-2.3	-0.3	-1.6
Hand grip strength (left)	1.7	4.5	8.7	-2.2	0.5	-2.9	-2.6	-0.8	-2.4
Trunk fat-free mass	1.7	9.7	17.5	-4.0	-1.3	-4.2	-3.2	-0.9	-3.4
Trunk predicted mass	1.7	9.5	17.0	-4.0	-1.3	-4.1	-3.1	-0.9	-3.4
Blood Eosinophil Count	1.6	12.5	48.7	0.4	-2.2	0.5	1.5	-7.0	4.3
Neck or shoulder pain in last month	1.6	2.3	4.9	-2.1	-1.4	-1.2	-0.1	1.1	-2.2
Supplements: Vitamin C	1.6	1.9	6.2	-0.9	-0.2	-0.5	-0.6	2.5	-2.0
Illnesses of father: None of the above (group 1)	1.6	2.0	3.8	-0.7	-1.3	-2.0	-1.4	0.7	-1.9
Intelligence (Savage-Jansen 2018)	1.5	4.5	7.2	2.7	1.7	2.5	2.4	1.1	1.8
Major Depression (MDD)	1.5	1.9	5.8	-1.0	1.0	-2.4	-1.0	0.6	-1.5
Birth weight	1.5	3.3	6.9	2.6	0.4	1.9	1.6	2.5	0.6
Ever had prostate specific antigen (PSA) test	1.5	1.7	3.9	-1.6	-0.1	-2.0	-1.4	0.4	-1.4
Medication: Co-codamol	1.4	1.7	3.5	-1.6	0.2	-1.3	-1.9	-0.7	-1.3
Leg predicted mass (left)	1.4	7.2	12.9	-3.0	-1.1	-3.6	-3.2	-0.7	-3.0
Lung cancer (father)	1.4	1.7	2.9	1.7	1.0	1.6	0.8	1.6	0.8
Medication: Blood pressure	1.4	2.5	5.4	1.3	0.5	2.3	1.8	-0.0	2.1
Whole body fat-free mass	1.4	8.2	15.1	-3.5	-1.1	-3.9	-3.2	-0.7	-3.2
Average weekly red wine intake	1.4	2.1	4.1	1.5	2.0	1.2	-0.1	1.4	1.8
Whole body water mass	1.4	8.1	14.9	-3.5	-1.0	-3.9	-3.2	-0.8	-3.1
Ulcerative Colitis	1.3	1.9	4.0	-1.8	0.6	-1.0	-1.7	-2.0	0.3
Leg fat-free mass (left)	1.3	7.0	12.7	-3.0	-1.1	-3.6	-3.1	-0.6	-3.0
Multivitamins +/- minerals	1.3	1.6	3.7	-1.9	-0.0	-1.2	-1.2	-1.5	-1.0
Medication: Ramipril	1.3	1.7	3.8	-0.4	1.8	1.0	-0.1	-1.5	2.0
Prospective memory result	1.3	1.5	2.3	1.3	1.5	1.1	1.1	1.3	1.1
Peak expiratory flow (PEF)	1.3	3.0	5.4	-1.9	-0.5	-2.3	-1.7	-0.6	-2.3
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	3.5	1.5	0.8	1.9	1.5	0.9	1.6
Arm predicted mass (right)	1.3	6.4	10.5	-3.2	-0.7	-3.2	-2.8	0.1	-3.0
Suffer from ‘nerves’	1.3	2.0	5.3	1.5	0.5	1.3	2.3	1.4	0.9
Leg pain on walking	1.3	1.6	2.7	1.3	-1.0	0.8	1.6	-1.2	1.6
Leg fat-free mass (right)	1.3	6.7	12.5	-2.9	-0.8	-3.5	-3.2	-0.6	-2.9
Mood swings	1.3	2.3	4.4	-1.1	-2.1	-1.8	-0.0	-0.5	-2.1
Mineral and other dietary supplements	1.3	1.8	4.8	1.8	1.0	1.2	0.3	-0.2	2.2
Leg predicted mass (right)	1.3	6.7	12.6	-2.9	-0.9	-3.5	-3.2	-0.6	-2.8
Basal metabolic rate	1.3	7.4	13.6	-3.3	-1.1	-3.7	-3.0	-0.9	-3.0
Arm fat-free mass (left)	1.3	6.8	12.5	-3.2	-1.4	-3.5	-2.6	-0.7	-3.0
Vascular/heart problems diagnosed by doctor	1.3	3.6	9.8	-1.1	-0.7	-3.1	-1.6	0.3	-2.6
Arm predicted mass (left)	1.3	6.4	11.9	-3.2	-1.0	-3.5	-2.7	-0.6	-2.9
Bipolar Disorder or Schizophrenia	1.2	2.9	7.1	-0.4	-1.6	-2.0	-1.7	0.9	-2.7
Chronotype (morning person)	1.2	2.7	4.8	1.9	0.6	2.1	2.2	0.9	1.5
Stomach or abdominal pain in last month	1.2	1.5	5.3	-1.1	-1.2	-1.0	-0.5	0.2	-2.3
Had menopause	1.2	1.4	3.4	1.5	0.4	1.3	1.8	0.2	1.1
Gout (self-reported)	1.2	1.7	4.5	1.9	-0.0	2.1	1.0	0.1	1.0
Chronic bronchitis/emphysema (mother)	1.2	1.4	4.4	-1.1	-2.1	-1.0	-0.7	-0.7	-1.0
Comparative body size at age 10	1.2	3.2	8.0	1.1	2.1	2.0	0.5	-1.2	2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.2	-1.1	-0.5	-0.8	-0.4	1.6	-1.8
Hearing aid user	1.2	1.4	4.2	-1.1	0.2	-1.5	-2.1	-0.3	-0.6
Schizophrenia vs Biploar Disorder	1.1	1.4	4.9	-0.1	0.2	0.3	0.4	-2.2	1.8
Crohns Disease (2017)	1.1	2.4	4.5	1.1	0.8	2.1	1.9	-0.5	2.0
Body Mass Index (BMI) (2010)	1.1	1.5	3.6	-0.8	-1.9	-1.4	-0.6	-0.1	-1.6
Schizophrenia (2014)	1.1	2.5	5.3	-1.1	-1.0	-2.1	-1.8	0.2	-2.3
Blood White Count	1.1	8.3	21.3	-3.3	2.1	-1.7	-4.6	-3.2	0.0
Hearing difficulty/problems: Yes	1.1	1.7	5.5	-1.0	0.7	-1.3	-2.3	-1.2	0.1
Forced vital capacity (FVC)	1.1	4.2	7.1	-2.7	-1.1	-2.3	-2.4	-1.9	-1.6
Hair/balding pattern: Pattern 3	1.1	1.6	3.2	1.8	-0.5	1.6	1.7	1.0	0.1
Shortness of breath walking on level ground	1.1	1.2	2.2	-1.3	-1.3	-1.5	-0.5	0.1	-1.2
Medication: Seretide 50 evohaler	1.1	1.3	3.1	-0.7	0.0	-1.7	-0.8	0.6	-1.8
Osteoarthritis (self-reported)	1.1	1.5	2.8	-1.7	-0.9	-1.7	-1.2	-0.4	-0.8
Alcohol drinker status: Never	1.1	1.3	3.9	1.0	0.2	1.5	0.8	2.0	0.1
Number of operations (self-reported)	1.1	1.7	4.6	-1.2	-0.1	-2.1	-1.5	-1.1	-0.6
Neuroticism (2016)	1.0	1.4	3.1	1.3	0.0	1.1	1.8	0.3	1.5
Primary Biliary Cirrhosis	1.0	1.5	3.5	-0.9	-1.2	-1.5	-1.1	0.1	-1.9
Triglycerides	1.0	1.6	3.3	1.8	1.4	0.9	1.1	0.6	1.3
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.3	-1.5	-1.4	-1.0	-0.8	-1.2	-0.9
Systolic blood pressure, automated reading	1.0	2.9	8.2	-2.9	0.8	-1.4	-1.7	-1.5	-1.2
Medication: Metformin	1.0	1.4	2.9	-0.3	1.7	0.4	-0.5	-1.5	1.6
Hair/balding pattern: Pattern 2	1.0	1.3	3.9	-0.3	-0.5	-1.0	-0.2	1.6	-2.0
Pulse rate	1.0	1.6	3.3	-1.5	-0.2	-1.8	-0.9	-1.4	-1.1
Number of full brothers	1.0	1.3	3.4	1.2	-0.2	1.0	1.2	1.9	-0.0
Qualifications: College or University degree	1.0	3.1	6.3	2.5	0.5	2.3	0.9	1.9	1.4
Medication: Allopurinol	1.0	1.3	4.2	2.0	-0.3	1.4	1.0	0.3	0.6
Ever had bowel cancer screening	1.0	1.2	2.8	0.9	0.9	0.7	1.4	1.7	0.7
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.0	-1.4	-0.5	-1.1	-0.7	-1.4	-0.7
High blood pressure	0.9	2.6	7.1	0.9	0.9	2.7	1.1	-0.4	2.4
Medication: Atenolol	0.9	1.1	3.9	0.5	-1.2	2.0	0.9	0.3	0.2
Heart attack	0.9	1.2	4.1	-0.1	-2.0	0.4	1.5	0.8	-0.3
Hip circumference	0.9	3.9	7.0	-2.6	-0.2	-2.6	-2.5	-0.8	-1.7
Ever depressed for a whole week	0.9	1.1	2.2	1.1	0.6	1.5	1.0	1.1	1.0
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.4	-0.3	-0.7	-0.8	-0.3	1.3	-1.8
Pain experienced in last month	0.9	1.6	4.6	0.3	1.0	0.6	-1.2	-1.4	2.1
Angina	0.8	1.0	3.2	0.7	-0.3	1.8	1.2	-0.1	0.9
Supplements: Glucosamine	0.8	1.0	3.1	0.3	-0.0	0.5	0.7	1.8	-1.5
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.1	1.5	0.5	1.2	1.0	0.4	0.7
Diabetes (self-reported)	0.8	1.2	3.3	-0.5	0.9	-0.5	-1.1	-1.8	1.0
Weight	0.8	4.2	7.5	-2.3	-0.9	-2.7	-2.4	-0.6	-2.2
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	4.7	-2.2	-0.6	-1.8	-2.1	-1.1	-1.7
Headache pain in last month	0.8	1.4	3.6	-0.7	-1.5	-1.3	0.0	-0.1	-1.9
Arm fat-free mass (right)	0.8	4.3	7.2	-2.7	-0.5	-2.7	-2.3	0.1	-2.4
Breast cancer (self-reported)	0.8	1.0	3.6	-0.5	-1.9	-0.9	-0.4	-0.4	-0.9
Age started oral contraceptive pill	0.8	1.0	2.2	1.1	-0.1	1.5	1.2	0.9	0.4
Cholesterol lowering medication	0.8	1.2	3.3	-0.9	-1.2	-1.0	-0.6	0.0	-1.8
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	1.6	-1.2	-1.0	-1.3	-0.8	-0.7	-1.0
Irritable Bowel Disease (IBD)	0.7	1.6	4.2	-0.6	0.8	0.9	0.1	-2.0	1.8
Type 2 Diabetes (T2D) (2018)	0.7	1.2	3.6	0.4	1.5	0.3	0.2	-1.1	1.9
Age when periods started (menarche)	0.7	1.8	6.1	-0.5	1.5	-0.2	-0.1	2.5	-1.3
Chronic bronchitis/emphysema (father)	0.7	0.8	1.7	-0.9	0.4	-1.3	-0.9	0.2	-1.0
Had other major operations	0.7	0.8	1.8	-0.9	-0.3	-0.8	-1.2	-1.3	-0.1
Qualifications: None of the above	0.7	1.4	3.3	-1.3	0.8	-1.8	-1.4	-0.6	-0.6
Time employed in main current job	0.7	0.8	1.4	-1.1	1.0	-0.5	-0.9	-1.2	-0.2
Alcohol intake versus 10 years previously	0.7	1.1	2.3	0.9	-1.5	0.5	1.4	1.0	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.9	0.9	-0.4	1.0	1.4	1.2	-0.2
Medication: Lansoprazole	0.7	0.8	1.9	-1.4	-0.3	-0.7	-1.4	-0.5	-0.6
Length of working week for main job	0.7	0.7	1.9	0.7	-0.9	1.4	1.1	-0.1	0.2
Tense / ‘highly strung’	0.7	1.1	2.5	-1.6	-0.6	-1.4	-0.2	0.4	-1.2
Blood clot in the leg (DVT)	0.7	0.9	1.5	-1.0	-1.1	-1.2	-0.5	-0.3	-1.2
Medication: Omeprazole	0.7	0.8	2.8	-0.5	-0.3	-0.8	-0.4	1.0	-1.7
Hypertension (Self-reported)	0.7	1.9	6.0	0.8	0.9	2.4	1.0	0.2	1.7
Smoking status: Current	0.7	1.1	2.2	-1.1	-0.5	-1.5	-0.7	-1.0	-1.3
Average weekly beer plus cider intake	0.7	1.0	3.6	-0.0	-0.8	-1.3	0.1	-1.9	-0.2
Risk taking	0.7	1.0	2.3	1.1	-0.0	0.5	0.5	-1.5	1.4
Alzheimer’s Disease (in mother)	0.6	0.7	2.4	-0.6	0.1	0.1	-0.4	-1.5	1.0
Crohns Disease (2012)	0.6	0.9	2.7	-0.4	1.6	1.1	0.6	-0.9	0.6
HbA1C	0.6	0.7	1.6	0.6	1.0	0.9	0.6	0.2	1.3
HDL Cholesterol	0.6	1.0	2.7	-1.6	0.1	-1.1	-0.9	0.1	-1.1
Lupus	0.6	0.9	1.9	1.2	0.8	0.6	0.9	-0.7	1.4
Systolic Blood Pressure	0.6	3.1	7.1	-2.7	2.4	0.0	-1.8	-1.5	-0.5
Lung FVC	0.6	2.8	9.5	0.9	3.1	1.3	-0.0	-0.2	2.2
Diabetes (father)	0.6	0.7	1.9	0.7	0.2	0.4	0.2	-1.2	1.4
Diabetes (mother)	0.6	0.8	1.2	-1.1	-0.8	-1.1	-0.6	-1.1	-0.6
Trunk fat mass	0.6	2.6	4.2	-1.5	-1.1	-2.0	-2.1	-0.3	-2.0
Waist circumference	0.6	2.1	3.6	-1.5	-1.3	-1.9	-1.4	0.1	-1.8
Worrier / anxious feelings	0.6	1.1	1.8	1.3	-0.0	1.0	1.3	1.3	0.8
High blood pressure (siblings)	0.6	0.8	3.6	-0.2	1.9	0.2	0.1	1.0	-0.4
Exposure to tobacco smoke outside home	0.6	0.8	1.7	-0.8	-1.3	-0.9	0.1	0.8	-1.0
Wheeze or whistling in the chest in last year	0.6	1.1	2.9	-0.4	-1.7	-1.2	0.1	-0.8	-1.1
Angina (self-reported)	0.6	0.8	2.9	0.6	-0.4	1.7	1.0	-0.0	0.7
Mean time to correctly identify matches	0.6	1.2	3.5	1.2	-0.7	0.4	0.8	1.9	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.2	-1.0	-0.6	-0.7	-0.9	-0.6	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.3	0.9	-0.1	1.1	0.6	1.1	0.5
Mother’s age at death	0.6	0.7	1.1	0.9	-0.8	-0.0	1.0	1.1	-1.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.2	-1.5	-0.4	-0.7	-0.6	-0.3	-1.1
Myopia	0.6	0.9	1.7	1.1	-0.8	1.3	1.0	0.8	0.6
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.3	-0.3	-1.5	0.1	1.1	1.0	-0.5
Cardiovascular Disease	0.5	1.5	3.9	0.1	0.6	2.0	0.4	-1.3	1.7
Relative age of first facial hair	0.5	1.0	4.2	-0.7	2.1	-0.2	-1.1	-0.5	0.3
Current tobacco smoking	0.5	0.9	1.7	-0.9	-0.5	-1.3	-0.5	-0.7	-1.3
Sitting height	0.5	3.7	7.1	-2.1	-1.9	-2.3	-1.1	-0.7	-2.7
Alcohol usually taken with meals	0.5	0.9	3.2	-0.8	1.8	0.5	-0.4	1.0	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.0	0.2	-0.8	0.0	1.3	1.4	-0.2
Father’s age at death	0.5	0.6	2.3	0.3	-0.0	-0.5	0.1	1.5	-1.0
Asthma	0.5	0.9	1.9	0.4	-1.0	0.6	0.6	-1.3	1.4
Breastfed as a baby	0.5	0.7	2.1	0.0	-0.3	1.2	0.5	-0.4	1.4
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.4	0.9	0.5	0.3	1.2	0.6	0.8
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.9	-0.4	-0.3	-1.4	-0.9	0.8	-1.4
Medication: Amlodipine	0.5	0.7	2.0	-0.5	0.8	0.3	0.1	-1.4	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.7	-0.8	0.3	-0.9	-1.3	-0.1	-0.7
Pulse wave peak to peak time	0.5	0.6	1.2	-0.5	-0.8	-1.1	-0.9	-0.4	-0.7
Whole body fat mass	0.5	2.2	3.6	-1.4	-1.0	-1.9	-1.9	-0.3	-1.9
Alcohol intake frequency.	0.5	1.1	1.9	0.8	-1.2	-0.1	0.9	1.4	-1.3
Age at last live birth	0.5	0.7	2.9	-0.3	-1.7	-0.6	-0.0	-0.2	-0.9
Knee pain experienced in last month	0.5	0.8	1.2	-1.1	1.1	-0.9	-0.9	0.2	-1.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.4	0.4	-1.5	-0.3	1.0	0.1	0.1
Diabetes diagnosed by doctor	0.5	0.8	2.4	0.3	1.0	0.3	-0.2	-1.0	1.6
Eye problems/disorders: Cataract	0.5	0.6	1.0	-1.0	0.1	-1.0	-0.9	-0.2	-0.7
Average weekly champagne plus white wine intake	0.5	0.7	2.7	0.5	0.8	0.9	-0.2	1.6	-0.4
Eye problems/disorders: Glaucoma	0.5	0.6	1.6	0.6	-1.2	0.8	1.0	-0.5	0.5
High cholesterol (Self-reported)	0.5	0.8	2.0	-0.9	-0.9	-0.7	-0.9	-0.2	-1.4
Medication: Bendroflumethiazide	0.5	0.8	1.9	-1.1	-0.1	-0.5	-1.1	-1.4	0.0
Bipolar Disorder (2018)	0.4	0.6	1.7	0.8	0.6	-0.1	-0.2	1.3	-0.9
Alzheimer’s Disease (in father)	0.4	0.4	2.4	0.0	1.5	0.0	-0.2	-0.1	0.4
Bipolar Disorder (2011)	0.4	0.4	0.9	1.0	-0.4	0.5	0.3	0.9	0.4
Coronary Artery Disease (CAD)	0.4	0.5	1.2	-0.6	-1.1	0.1	-0.4	-1.1	0.1
Mean Putamen Volume	0.4	0.5	1.2	1.1	1.1	-0.2	0.3	0.7	-0.1
Fasting Glucose	0.4	0.4	1.1	-0.5	-0.6	-1.1	-0.3	-0.1	-0.8
LDL Cholesterol	0.4	0.7	2.1	-0.1	0.5	-0.1	-0.6	1.5	-1.2
Hypothyroidism (self reported)	0.4	0.9	2.0	1.4	0.4	0.9	1.1	0.9	0.5
Respiratory disease	0.4	1.0	3.0	-1.0	-0.3	-0.9	-0.9	-1.7	-0.1
Tanning	0.4	4.7	13.5	-1.5	-2.5	-2.2	-1.0	-3.7	-0.8
Sensitivity / hurt feelings	0.4	0.6	1.7	-0.7	-0.3	-1.2	0.1	-1.3	0.3
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.5	-0.3	-0.4	-0.6	0.4	1.2	-1.1
Medication for hormone replacement therapy	0.4	0.5	0.9	-1.0	0.4	-0.7	-0.9	-0.4	-0.6
Serious illness, injury or assault to yourself	0.4	0.5	1.1	-0.4	0.6	-0.8	-0.4	0.6	-1.0
Medication: Levothyroxine sodium	0.4	0.7	1.3	-0.4	1.0	-0.8	-0.7	0.8	-1.1
High blood pressure (mother)	0.4	0.5	1.2	-0.8	1.1	0.8	0.5	0.2	0.5
Hearing difficulty/problems with background noise	0.4	0.6	1.1	-0.9	0.9	-1.1	-1.0	0.3	-0.4
Medication: Cholesterol lowering	0.4	0.7	1.6	0.5	0.8	1.2	0.3	-0.3	1.3
Loud music exposure frequency	0.4	0.4	0.9	-0.7	0.5	-0.1	-0.2	0.7	-1.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.6	0.9	-0.1	1.2	0.6	-0.5	0.3
Glaucoma (self-reported)	0.4	0.5	1.3	0.2	-1.2	0.5	1.1	-0.4	0.4
Forced vital capacity (FVC), Best measure	0.4	1.3	2.3	-1.4	-0.2	-1.1	-1.5	-1.3	-0.7
Health satisfaction	0.4	0.5	1.8	-0.4	-1.4	-0.2	0.8	-0.7	0.0
Medication: Ibuprofen	0.4	0.4	1.4	0.4	-0.1	0.4	0.4	1.2	-0.8
Heart disease (mother)	0.4	0.5	2.1	-0.2	0.9	0.6	0.1	1.4	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.3	-0.3	0.3	-0.6	-0.9	-1.1	0.4
Smoking status: Previous	0.4	0.5	1.5	0.7	0.4	0.5	0.5	1.2	0.7
Friendships satisfaction	0.4	0.5	1.5	-0.8	-0.5	-0.3	-0.9	-1.2	0.3
Qualifications: nursing, teaching	0.4	0.6	1.8	-0.1	1.2	0.5	-0.4	1.4	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.8	0.8	1.1	0.8	0.3	-0.4	1.3
Number of self-reported non-cancer illnesses	0.4	0.7	2.8	-0.4	-1.7	-0.0	-0.4	-1.0	-0.3
Wears glasses or contact lenses	0.4	0.5	0.9	0.9	-0.5	0.8	0.8	0.4	0.4
Ever taken oral contraceptive pill	0.4	0.5	2.2	-0.1	-0.4	0.3	-0.3	-1.5	0.4
Commuting to job workplace: Public transport	0.4	0.5	1.1	0.8	1.0	0.4	0.7	-0.5	0.6
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.3	0.8	0.0	1.1	0.4	1.0	-0.1
Medication: Paracetamol	0.4	0.7	1.7	-0.5	-0.6	-0.4	-0.6	1.3	-1.1
Ever smoked	0.4	0.6	3.0	0.5	-1.7	-0.0	0.7	0.2	0.2
Basal cell carcinoma (self-reported)	0.4	0.5	1.2	-1.1	-0.0	-0.9	-0.6	0.4	-0.5
Alcohol drinker status: Previous	0.4	0.4	1.3	-0.1	0.3	-0.3	-0.4	0.9	-1.2
Depressed Affect (Nagel 2018)	0.3	0.6	1.6	-0.7	-0.1	-1.2	0.1	-1.3	-0.4
Neuroticism (Nagel 2018)	0.3	0.6	1.7	-0.9	0.7	-1.3	0.2	-0.8	0.1
Reaction Time	0.3	0.6	1.7	0.9	-0.7	0.5	0.6	1.3	-0.2
Ovarian Cancer	0.3	0.3	1.0	0.1	1.0	0.5	0.8	-0.0	0.4
Prostate Cancer	0.3	0.5	2.0	0.6	1.4	0.0	-0.4	0.7	0.2
Waist Hip Ratio (WHR)	0.3	1.2	5.9	0.1	-2.4	-0.2	0.2	0.4	-1.0
Lung FEV1/FVC ratio	0.3	1.5	4.7	-0.1	1.8	0.1	-0.6	2.2	-0.8
Neuroticism	0.3	0.7	1.8	-0.5	-0.1	-0.9	1.1	-1.3	0.7
Hair Pigment	0.3	8.7	17.6	3.8	-0.9	3.2	4.2	-0.6	3.0
Severe depression (siblings)	0.3	0.4	0.6	0.2	-0.6	-0.8	0.7	-0.8	-0.4
Average weekly fortified wine intake	0.3	0.4	1.1	-0.8	1.0	-0.1	-0.8	0.3	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.6	0.4	-0.4	0.2	1.3	0.6	-0.1
Relative age voice broke	0.3	0.5	2.2	0.3	1.5	0.1	0.4	0.5	0.5
Taking other prescription medications	0.3	0.4	1.4	-0.4	-0.7	-0.4	-0.3	-1.2	0.2
Illnesses of siblings	0.3	0.4	1.2	0.6	-0.8	0.4	0.5	0.2	1.1
Impedance of arm (right)	0.3	1.3	4.5	-0.4	-2.1	-0.6	-0.6	-1.0	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.0	-0.5	-1.0	-0.8	-0.3	-0.2	-0.7
Number of live births	0.3	0.4	1.0	0.7	-0.1	0.3	1.0	-0.0	1.0
Noisy workplace	0.3	0.4	0.8	-0.5	-0.6	-0.9	-0.6	-0.2	-0.7
Depression (self-reported)	0.3	0.3	0.7	-0.5	0.2	-0.7	-0.8	-0.7	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.5	-1.1	0.5	-0.8	-1.6	-0.8	-1.0
Arm fat mass (right)	0.3	1.3	2.5	-1.0	-0.5	-1.6	-1.3	-0.8	-1.3
Medication: Paracetamol	0.3	0.5	1.2	-0.7	-1.1	-0.4	-0.0	0.6	-0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.3	0.3	-1.1	-0.4	-0.0	-0.8	0.1
Number of children fathered	0.3	0.3	1.1	0.7	0.4	0.1	0.0	-0.5	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.8	-0.7	-0.6	-0.8	-0.9	-0.1	0.3
Pulse rate, automated reading	0.3	0.8	3.9	0.2	-0.2	-0.2	0.2	-2.0	0.9
Medication: Aspirin	0.3	0.5	1.0	-0.0	1.0	0.9	0.6	0.6	0.3
Medication for cholesterol	0.3	0.5	1.3	1.1	0.5	-0.0	0.5	0.5	1.1
Asthma (self-reported)	0.3	0.7	2.0	0.1	-0.8	0.3	0.3	-1.4	1.1
Medication: Blood pressure	0.3	0.6	1.5	-1.2	0.4	0.8	-0.5	-0.9	0.4
Diastolic blood pressure, automated reading	0.3	1.0	2.3	-1.5	0.9	-0.6	-0.5	-1.5	-0.5
Heart disease (siblings)	0.3	0.4	1.6	-0.1	-0.3	0.6	0.5	0.1	-1.3
Depression (Nagel 2018)	0.2	0.3	1.2	-0.2	0.5	-0.3	1.1	0.1	0.3
Worry (Nagel 2018)	0.2	0.4	1.4	0.2	0.6	-0.2	1.2	0.7	0.5
Age at First Birth	0.2	0.3	1.2	-0.0	-0.1	0.0	-0.3	1.1	-0.7
Smoking Status	0.2	0.4	1.1	0.8	-0.4	0.3	1.0	0.6	0.2
Average weekly spirits intake	0.2	0.2	0.8	-0.2	-0.3	-0.5	-0.9	-0.0	-0.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.8	0.4	-0.1	0.5	0.7	-0.1	0.9
Trunk fat percentage	0.2	0.7	1.5	-0.3	-0.9	-0.8	-1.2	-0.1	-1.1
Townsend deprivation index at recruitment	0.2	0.3	0.7	-0.4	-0.5	-0.8	-0.5	-0.8	-0.0
Fed-up feelings	0.2	0.3	1.0	0.3	-0.0	-0.5	1.0	-0.6	-0.1
Qualifications: CSEs or equivalent	0.2	0.2	0.5	-0.1	-0.7	-0.7	0.2	-0.3	-0.5
Impedance of leg (left)	0.2	0.8	1.9	0.5	-1.4	1.2	0.9	-0.4	0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.7	0.1	-0.1	0.5	-0.3	-0.9	0.4
Medication: Simvastatin	0.2	0.3	1.0	-0.0	0.2	0.6	-0.1	-1.0	0.7
Happiness	0.2	0.2	0.6	-0.5	0.2	-0.2	-0.3	-0.8	0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.9	0.9	-0.4	1.0	0.4	0.5	0.7
Mouth/teeth dental problems: Dentures	0.2	0.3	1.0	0.2	-1.0	0.5	0.4	-0.6	0.3
Illnesses of mother	0.2	0.3	1.0	1.0	0.4	-0.3	0.2	0.2	-0.4
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	-0.0	0.5	0.6	0.5	0.4	0.3
Worry too long after embarrassment	0.2	0.4	0.8	-0.6	-0.4	0.0	-0.2	-0.9	0.9
Medication for pain relief, constipation, heartburn	0.2	0.4	1.1	0.2	1.1	-0.1	-0.6	-0.4	0.8
Leg fat mass (right)	0.2	0.7	1.1	-0.8	-0.6	-1.0	-1.0	-0.4	-1.0
Number of full sisters	0.2	0.2	0.5	0.2	0.2	0.3	-0.4	-0.7	0.7
Overall health rating	0.2	0.5	1.1	0.2	-1.0	-0.1	1.0	-0.8	-0.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	-0.2	-0.5	0.1	-0.4	-0.7	0.7
Commuting to job workplace: Walk	0.2	0.2	0.8	-0.4	0.9	-0.2	-0.6	0.3	0.3
Back pain experienced in last month	0.2	0.2	0.7	-0.4	-0.0	-0.7	0.2	-0.2	-0.8
Arm fat mass (left)	0.2	0.8	1.5	-0.8	-0.3	-1.2	-1.2	-0.4	-1.0
Medication: Atorvastatin	0.2	0.3	1.1	-0.5	0.4	0.1	0.1	1.1	-0.4
Unable to work because of sickness or disability	0.2	0.2	0.7	-0.2	0.4	0.3	-0.8	-0.5	0.2
Commuting to job workplace: Cycle	0.2	0.2	0.4	-0.4	-0.1	0.6	-0.4	-0.5	0.4
Alzheimer’s Disease (including proxy)	0.1	0.2	0.5	0.1	0.5	0.6	0.4	-0.1	0.7
Blood Platelet Count	0.1	1.2	4.2	0.4	-1.3	0.0	-2.0	-0.7	-0.8
Blood Red Count	0.1	1.3	2.9	0.9	1.4	1.3	0.9	-0.1	1.7
Number of treatments/medications taken	0.1	0.2	0.5	-0.7	-0.1	0.3	-0.7	-0.5	-0.1
Impedance of leg (right)	0.1	0.6	2.2	-0.1	-1.5	0.7	0.7	-0.4	-0.3
Maternal smoking around birth	0.1	0.2	0.4	0.6	0.3	0.2	-0.0	-0.5	0.4
Past tobacco smoking	0.1	0.2	0.6	-0.5	0.5	-0.0	-0.4	-0.8	-0.4
Nervous feelings	0.1	0.1	0.2	-0.4	0.0	0.1	0.5	0.3	0.5
Financial difficulties in last 2 years	0.1	0.1	0.3	0.3	-0.1	-0.2	-0.4	-0.3	0.6
Neuroticism score	0.1	0.3	0.7	-0.4	-0.3	-0.5	0.8	-0.7	0.4
Arm fat percentage (right)	0.1	0.3	0.5	0.0	-0.4	-0.6	-0.7	-0.6	-0.4
Impedance of arm (left)	0.1	0.4	1.6	0.1	-1.3	0.1	-0.5	-0.2	-0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	0.4	-0.4	-0.1	0.1	0.0	-0.5
Body fat percentage	0.1	0.4	0.7	-0.2	-0.8	-0.5	-0.8	-0.2	-0.7
Age at first live birth	0.1	0.2	1.0	-0.2	-1.0	0.3	-0.2	0.1	-0.2
Eye problems/disorders: None of the above	0.1	0.1	0.4	-0.2	0.6	0.1	-0.2	0.1	0.6
Loneliness, isolation	0.1	0.2	0.5	0.7	0.3	0.7	0.1	0.4	0.0
Long-standing illness, disability or infirmity	0.1	0.1	0.3	0.1	-0.2	-0.3	0.3	0.1	-0.5
Medication: Aspirin	0.1	0.2	0.5	-0.7	0.7	0.3	-0.1	0.1	0.0
Miserableness	0.1	0.2	0.4	-0.6	0.2	-0.6	0.4	-0.4	-0.3
Guilty feelings	0.1	0.1	0.6	0.0	-0.3	-0.1	0.8	0.0	0.2
Medication: Lisinopril	0.1	0.1	0.4	-0.1	0.1	0.2	-0.6	-0.1	0.6
Irritability	0.1	0.1	0.5	-0.4	-0.0	-0.5	0.7	-0.1	-0.0
Impedance of whole body	0.1	0.5	2.2	0.4	-1.5	0.8	0.3	-0.1	-0.3
Leg fat mass (left)	0.1	0.6	1.0	-0.6	-0.6	-0.9	-1.0	-0.4	-0.8
BMI	0.0	0.1	0.2	-0.1	-0.2	-0.3	-0.4	-0.3	0.1
Body mass index (BMI)	0.0	0.1	0.5	0.1	0.7	-0.1	-0.3	-0.0	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.2	0.1	-0.4	0.1	-0.3	0.1	0.2
Leg fat percentage (right)	0.0	0.0	0.1	0.1	-0.1	0.1	-0.1	-0.3	0.0
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	0.1	-0.2	0.1	-0.1	-0.0	0.2
Arm fat percentage (left)	0.0	0.1	0.2	0.4	0.0	-0.0	-0.5	-0.2	0.1
Leg fat percentage (left)	0.0	0.1	0.2	0.4	0.1	0.3	-0.0	-0.4	0.5

Hub : Genes

CRTC3

Models

Trait associations