TWAS hub - NAE1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.2680	0.0740	3.7e-06	0.038	NA	0.034	NA	0.022	7.9e-04	NA	1.4e-03	NA	7.9e-03
2	GTEx	Esophagus Mucosa	0.0950	0.0410	1.2e-03	0.076	NA	0.049	NA	0.063	8.3e-06	NA	3.3e-04	NA	4.7e-05
3	YFS	Blood	0.0432	0.0147	5.4e-10	0.026	0.034	0.030	0.035	0.029	5.3e-09	2.2e-11	3.7e-10	1.2e-11	8.1e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Heel bone mineral density (BMD) T-score, automated (left)	7.1	16.2	29.3	-3.4	-2.8	-5.4
Breast cancer (self-reported)	6.8	8.2	10.3	2.1	3.1	3.2
Heel T-Score	6.7	53.4	75.5	-7.2	-5.7	-8.7
Handedness (chirality/laterality): Left-handed	6.1	7.3	9.9	-1.6	-3.1	-3.1
Pulse rate, automated reading	5.8	18.6	33.7	-1.1	-5.8	-4.6
Illnesses of father: High blood pressure	5.3	6.6	7.8	-2.7	-2.8	-2.2
Rheumatoid Arthritis	5.0	6.9	9.8	1.9	3.1	2.7
Pulse rate	5.0	8.5	14.0	-0.5	-3.7	-3.4
Heel bone mineral density (BMD) T-score, automated (right)	4.9	11.3	21.0	-2.8	-2.3	-4.6
Osteoporosis (self-reported)	4.6	5.7	8.9	3.0	1.7	2.3
Commuting to job workplace: Walk	4.4	4.7	8.7	-0.8	-2.2	-3.0
Fasting Glucose	4.1	4.9	7.9	1.2	2.8	2.3
Age at First Birth	3.9	5.7	8.2	-2.6	-1.5	-2.9
Illnesses of father: None of the above (group 1)	3.8	4.7	6.1	1.9	2.1	2.5
High blood pressure	3.7	10.3	14.5	-2.6	-3.1	-3.8
Vascular/heart problems diagnosed by doctor	3.7	10.1	13.4	2.6	3.1	3.7
Schizophrenia (2018)	3.5	7.2	12.6	-1.0	-3.5	-2.8
Bipolar Disorder or Schizophrenia	3.4	8.3	10.5	-2.0	-3.2	-3.2
Systolic Blood Pressure	3.3	16.7	20.2	-3.5	-4.2	-4.5
Medication: Blood pressure	3.1	5.8	8.7	-1.6	-2.5	-2.9
Cardiovascular Disease	2.9	9.7	12.8	-3.0	-2.7	-3.6
Risk taking	2.9	4.2	6.4	-1.5	-2.0	-2.5
Exposure to tobacco smoke outside home	2.8	3.8	5.7	-1.1	-2.1	-2.4
Alcohol drinker status: Never	2.8	3.4	4.9	1.2	1.9	2.2
Schizophrenia (2014)	2.7	6.0	9.7	-1.1	-3.1	-2.7
Respiratory disease	2.7	5.9	11.0	-0.7	-3.3	-2.5
Mouth/teeth dental problems: Bleeding gums	2.7	3.5	4.8	-1.5	-1.9	-2.2
Hypertension (Self-reported)	2.7	7.4	10.4	-2.3	-2.6	-3.2
Commuting to job workplace: Public transport	2.7	3.3	4.2	-1.6	-1.7	-2.1
Medication for cholesterol	2.6	3.9	6.0	1.1	2.1	2.4
Hair/balding pattern: Pattern 2	2.5	3.2	4.6	-2.1	-1.2	-1.9
High blood pressure (siblings)	2.5	3.6	6.6	-0.9	-1.9	-2.6
Number of children fathered	2.5	2.9	5.6	-1.0	-1.4	-2.4
Illnesses of father: Heart disease	2.5	3.5	5.4	-2.3	-1.5	-1.7
Medication: Bendroflumethiazide	2.5	3.8	8.4	-0.8	-1.5	-2.9
Diastolic blood pressure, automated reading	2.5	7.6	11.4	-2.0	-3.4	-2.8
Had other major operations	2.4	3.0	4.3	0.8	2.1	2.0
Triglycerides	2.3	3.8	7.0	-1.4	-1.5	-2.6
Chronic bronchitis/emphysema (mother)	2.3	2.7	3.3	1.4	1.8	1.6
Eye problems/disorders: Glaucoma	2.3	2.7	3.4	1.8	1.7	1.4
Medication: Blood pressure	2.2	3.8	4.5	-1.9	-1.8	-2.1
Average weekly spirits intake	2.1	2.6	3.3	1.8	1.5	1.5
Systolic blood pressure, automated reading	2.1	6.0	7.3	-2.1	-2.7	-2.5
Medication: Atenolol	2.1	2.6	4.5	-1.0	-1.5	-2.1
Ulcerative Colitis (UC)	2.0	3.8	6.8	0.9	2.6	1.9
Bipolar Disorder (2018)	1.9	3.0	5.5	-2.3	-0.8	-1.7
Chronic bronchitis/emphysema (father)	1.8	2.1	4.1	2.0	1.3	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	3.0	1.4	1.7	1.2
Supplements: Calcium	1.8	1.9	2.8	1.6	0.6	1.7
Asthma (self-reported)	1.7	3.4	6.4	-0.6	-2.5	-1.9
Myopia	1.7	2.4	4.9	-2.2	-1.1	-1.1
Townsend deprivation index at recruitment	1.6	2.2	3.1	0.9	1.7	1.8
Hayfever, allergic rhinitis or eczema	1.6	3.5	5.8	2.4	0.7	2.1
Asthma	1.6	3.1	5.4	-0.8	-2.3	-1.8
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	4.5	2.1	1.3	1.4
Alcohol intake frequency.	1.6	3.6	4.4	1.9	1.7	2.1
Ulcerative Colitis	1.5	2.1	5.0	0.1	2.2	1.1
Medication for hormone replacement therapy	1.5	1.7	3.2	-0.7	-1.8	-1.2
Average weekly fortified wine intake	1.5	1.8	4.1	-0.7	-2.0	-0.9
Falls in the last year	1.5	2.0	3.6	-0.0	-1.9	-1.6
Medication: Ventolin 100micrograms inhaler	1.5	1.9	5.0	-0.7	-2.2	-0.6
Qualifications: College or University degree	1.5	4.8	9.1	-1.5	-1.7	-3.0
Type 2 Diabetes (T2D) (2018)	1.4	2.5	3.2	1.2	1.8	1.7
Taking other prescription medications	1.4	2.2	2.6	1.3	1.6	1.4
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	4.2	2.1	-0.8	0.8
Illnesses of siblings	1.4	2.0	3.8	0.1	1.5	1.9
Headache pain in last month	1.4	2.5	5.9	-0.1	-2.4	-1.2
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.5	0.8	1.2	1.6
Hypothyroidism (self reported)	1.3	2.9	4.4	0.7	2.0	2.1
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.4	0.7	1.5	1.3
Gout (self-reported)	1.3	1.8	2.4	1.1	1.4	1.6
Number of full sisters	1.3	1.6	2.5	0.9	1.6	1.3
Eye problems/disorders: Cataract	1.3	1.5	2.3	-0.8	-1.5	-1.2
Pain experienced in last month	1.3	2.2	2.5	1.2	1.6	1.6
Tense / ‘highly strung’	1.2	1.9	5.1	0.5	-2.2	-0.7
Hair/balding pattern: Pattern 4	1.2	2.9	8.1	2.8	0.3	0.7
Ever highly irritable/argumentative for 2 days	1.2	1.5	2.3	-1.1	-1.5	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	1.9	-1.1	-1.4	-1.3
Qualifications: nursing, teaching	1.2	1.8	2.5	-1.4	-0.9	-1.6
Pain type(s) experienced in last month: Hip pain	1.2	1.5	1.6	-1.3	-1.3	-1.1
Schizophrenia vs Biploar Disorder	1.1	1.5	2.2	1.4	-1.5	-0.5
Irritable Bowel Disease (IBD)	1.1	2.7	6.9	0.2	2.6	1.1
Fed-up feelings	1.1	2.0	2.5	1.5	1.0	1.6
Qualifications: None of the above	1.1	2.4	3.6	1.2	1.4	1.9
Lung cancer (father)	1.1	1.3	3.7	1.9	0.3	0.5
Financial situation satisfaction	1.1	1.3	1.9	1.4	1.1	1.0
Worry (Nagel 2018)	1.0	2.1	5.5	0.3	-2.4	-0.7
Neuroticism (2016)	1.0	1.4	3.3	1.8	-0.0	0.9
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.0	0.3	1.1	1.4
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.8	1.3	-0.7	-1.0
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	2.8	0.9	1.4	1.7
Chest pain or discomfort	1.0	1.4	2.4	1.2	0.5	1.6
Prostate Cancer	0.9	1.3	1.7	-1.1	-1.3	-1.0
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.2	-0.9	-1.5	-0.6
Glaucoma (self-reported)	0.9	1.0	1.6	0.3	1.1	1.3
Eye problems/disorders: None of the above	0.9	1.0	1.7	-0.2	1.3	1.2
Migraine (self-reported)	0.9	1.1	2.4	-0.3	-1.5	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.7	-0.3	-0.8	-1.6
Friendships satisfaction	0.9	1.2	2.0	0.4	-1.2	-1.4
Mineral and other dietary supplements	0.9	1.2	2.7	-0.4	0.8	1.6
Ever taken oral contraceptive pill	0.9	1.0	1.7	0.0	1.3	1.1
Ever depressed for a whole week	0.9	1.2	1.7	-1.3	-1.2	-0.6
Alzheimer’s Disease (in mother)	0.8	0.9	2.2	0.7	-1.5	-0.3
Bipolar Disorder (2011)	0.8	0.8	2.5	0.0	0.0	-1.6
Blood Eosinophil Count	0.8	6.4	9.9	2.8	1.2	3.1
Number of treatments/medications taken	0.8	1.4	2.5	-0.4	-1.6	-1.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.9	1.0	0.5	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.1	-0.9	-1.4	-0.8
Hearing difficulty/problems with background noise	0.8	1.3	3.9	-0.3	-2.0	-0.2
Financial difficulties in last 2 years	0.8	1.1	2.2	0.4	0.9	1.5
Diabetes (self-reported)	0.8	1.3	1.4	1.0	1.2	1.2
Birth weight of first child	0.8	1.4	3.5	0.4	1.9	0.6
Mean time to correctly identify matches	0.8	1.5	2.3	-0.7	-1.5	-1.3
Ever had bowel cancer screening	0.8	1.0	1.3	0.5	1.1	1.2
Diabetes diagnosed by doctor	0.8	1.3	1.8	0.8	1.2	1.3
Ever smoked	0.8	1.3	2.1	-0.7	-1.2	-1.5
Alzheimer’s Disease (including proxy)	0.7	1.0	2.9	0.4	-1.7	-0.2
BMI	0.7	4.1	7.9	-1.6	2.8	1.4
Allergy or Eczema	0.7	1.7	3.6	1.9	-0.0	1.3
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.1	-1.0	-0.8	-1.0
Stomach or abdominal pain in last month	0.7	0.9	1.2	-1.0	-1.1	-0.8
Trunk fat mass	0.7	2.8	6.2	-1.3	2.5	0.9
Nervous feelings	0.7	1.2	3.5	-0.4	-1.9	-0.1
Allergy	0.7	1.5	3.5	-1.9	0.5	-0.9
Hip circumference	0.7	3.2	7.0	-0.6	2.6	1.5
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.2	-0.6	-1.0	-1.1
Emphysema/chronic bronchitis	0.7	0.8	1.2	1.0	0.4	1.1
Mood swings	0.7	1.3	2.2	1.2	0.5	1.5
Average weekly beer plus cider intake	0.7	1.0	1.1	-1.0	-0.9	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.9	1.4	0.6	0.5
Alcohol drinker status: Previous	0.7	0.7	1.5	1.2	0.4	0.8
Depressed Affect (Nagel 2018)	0.6	1.3	2.7	1.6	0.5	1.0
Ovarian Cancer	0.6	0.8	1.1	0.6	1.0	1.0
Neuroticism	0.6	1.3	1.9	1.4	-1.2	0.8
Sensitivity / hurt feelings	0.6	1.0	1.3	1.2	1.0	0.9
Trunk fat percentage	0.6	2.2	4.7	-0.7	2.2	1.2
Had menopause	0.6	0.8	1.7	0.5	0.6	1.3
Weight	0.6	3.1	6.7	-1.5	2.6	0.7
Pulse wave Arterial Stiffness index	0.6	0.7	0.9	-1.0	-0.9	-0.5
Arm fat mass (right)	0.6	2.4	5.2	-1.2	2.3	0.8
Forced vital capacity (FVC), Best measure	0.6	2.3	4.5	0.2	2.1	1.5
Comparative body size at age 10	0.6	1.5	4.2	-0.2	-0.6	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.9	-0.4	-0.3	-1.4
Whole body fat mass	0.6	2.7	5.8	-1.2	2.4	0.8
Leg fat mass (right)	0.6	2.2	5.1	-1.0	2.2	0.7
Suffer from ‘nerves’	0.6	0.9	1.6	-0.4	-1.3	0.9
Age at last live birth	0.6	0.9	1.8	1.3	0.8	0.4
Family relationship satisfaction	0.6	0.7	1.2	0.4	-0.9	-1.1
Knee pain experienced in last month	0.6	1.0	1.6	-0.8	-0.8	-1.3
Smoking status: Previous	0.6	0.9	1.8	-0.2	-0.9	-1.4
Arm fat percentage (left)	0.6	2.3	4.8	-0.8	2.2	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.2	-0.3	1.3	1.5
Arm fat mass (left)	0.6	2.3	5.0	-1.2	2.2	0.7
Average weekly champagne plus white wine intake	0.6	0.8	1.5	-1.2	-0.8	-0.6
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.0	1.0	-0.4	-1.0
Crohns Disease (2017)	0.5	1.1	2.6	-0.8	1.6	-0.2
Breast Cancer	0.5	1.3	2.0	-1.2	-1.4	-0.7
Mean Putamen Volume	0.5	0.6	1.7	-0.1	-1.3	-0.2
LDL Cholesterol	0.5	0.9	1.9	0.0	-1.4	-0.8
Chronotype (morning person)	0.5	1.3	2.3	0.6	1.5	1.1
Leg fat-free mass (left)	0.5	2.5	4.1	-1.9	2.0	0.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.3	1.1	0.6	0.1
High blood pressure (mother)	0.5	0.7	0.9	-0.7	-1.0	-0.8
Body mass index (BMI)	0.5	2.3	4.5	-0.9	2.1	1.3
Leg predicted mass (left)	0.5	2.5	4.3	-1.8	2.1	0.3
Number of incorrect matches in round	0.5	0.8	2.0	0.5	-1.4	-0.1
Past tobacco smoking	0.5	0.8	1.8	-0.0	0.9	1.3
Trunk fat-free mass	0.5	2.7	4.2	-1.9	2.0	-0.6
Father’s age at death	0.5	0.6	1.7	0.0	1.3	0.4
Trunk predicted mass	0.5	2.6	4.1	-1.8	2.0	-0.7
Loud music exposure frequency	0.5	0.5	0.8	0.5	0.8	0.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.1	-0.7	0.8	1.0
Medication: Paracetamol	0.5	0.8	1.3	-0.4	-1.1	-1.0
Body fat percentage	0.5	2.1	4.8	-0.7	2.2	1.1
Leg fat percentage (right)	0.5	1.9	4.6	-0.4	2.1	0.9
Pulse wave peak to peak time	0.5	0.6	0.8	0.9	0.9	0.2
Medication: Aspirin	0.5	0.6	0.9	-0.5	-1.0	-0.8
Supplements: Vitamin C	0.5	0.6	1.7	1.3	-0.3	0.2
Whole body fat-free mass	0.5	2.6	4.5	-1.8	2.1	-0.2
Medication: Aspirin	0.5	0.6	1.1	-0.3	-1.0	-0.9
Whole body water mass	0.5	2.7	4.0	-2.0	1.9	-0.4
Guilty feelings	0.5	0.8	1.2	-0.8	-1.1	0.7
Mother’s age at death	0.5	0.7	1.0	-0.4	-0.9	-1.0
Medication: Atorvastatin	0.5	0.7	0.9	0.8	0.9	0.6
Basal metabolic rate	0.5	2.8	5.1	-1.8	2.3	-0.1
Alzheimer’s Disease (in father)	0.4	0.5	0.8	-0.7	-0.9	-0.5
Verbal and Numeric Reasoning (VNR)	0.4	0.8	1.7	1.3	-0.0	0.9
Coronary Artery Disease (CAD)	0.4	0.5	0.7	0.9	0.8	-0.3
Crohns Disease (2012)	0.4	0.6	1.0	-0.8	1.0	-0.4
HDL Cholesterol	0.4	0.7	2.0	0.0	-1.4	0.5
Lupus	0.4	0.6	1.4	-0.0	-1.2	-0.6
Blood Platelet Count	0.4	5.1	6.6	-2.6	-2.0	-2.1
Blood Red Count	0.4	3.6	8.7	-3.0	-1.4	-0.4
Sitting height	0.4	3.1	5.6	-2.4	0.7	-1.8
Neuroticism score	0.4	0.9	1.4	0.8	-1.2	0.9
Arm fat percentage (right)	0.4	1.6	3.3	-0.9	1.8	0.8
Number of live births	0.4	0.6	0.8	-0.7	-0.9	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.6	-0.5	1.6	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.7	-1.3	-0.5	0.1
Peak expiratory flow (PEF)	0.4	1.0	2.1	-0.4	1.4	0.9
Pulse wave reflection index	0.4	0.5	0.8	-0.9	0.3	0.7
Arm fat-free mass (right)	0.4	2.3	3.7	-1.9	1.7	-0.5
Worry too long after embarrassment	0.4	0.7	2.1	0.2	-1.4	-0.3
Wheeze or whistling in the chest in last year	0.4	0.6	1.3	1.1	-0.8	0.1
Medication for pain relief, constipation, heartburn	0.4	0.8	1.4	-0.2	1.2	0.9
Arm predicted mass (right)	0.4	2.0	3.4	-1.8	1.4	-0.7
Leg pain on walking	0.4	0.5	1.1	1.0	0.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.6	-1.3	0.8	-0.8
Leg fat-free mass (right)	0.4	1.9	3.0	-1.7	1.7	0.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.3	-0.7	-0.5	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.1	-0.3	-1.0	-0.6
Medication: Gliclazide	0.4	0.4	0.9	-0.9	-0.6	0.2
Leg predicted mass (right)	0.4	1.9	3.0	-1.7	1.7	0.1
High cholesterol (Self-reported)	0.4	0.7	1.5	-1.2	-0.7	-0.4
Arm fat-free mass (left)	0.4	2.2	3.4	-1.8	1.6	-0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.1	0.1	0.7	1.1
Leg fat mass (left)	0.4	1.5	3.0	-1.2	1.7	0.3
Arm predicted mass (left)	0.4	2.2	3.1	-1.8	1.7	-0.8
Depression (Nagel 2018)	0.3	0.5	0.7	0.7	-0.4	-0.8
Neuroticism (Nagel 2018)	0.3	0.8	1.5	1.2	-0.8	0.5
Major Depression (MDD)	0.3	0.4	1.1	1.0	-0.2	-0.2
Reaction Time	0.3	0.6	1.0	-0.3	-0.9	-1.0
Hand grip strength (left)	0.3	0.9	1.5	-0.8	-0.7	-1.2
Hearing difficulty/problems: Yes	0.3	0.5	1.4	0.3	0.2	1.2
Supplements: Zinc	0.3	0.4	1.0	1.0	-0.4	-0.0
Diabetes (father)	0.3	0.3	0.5	0.7	-0.6	-0.4
Diabetes (mother)	0.3	0.4	0.8	-0.1	0.6	0.9
Hand grip strength (right)	0.3	0.8	1.6	-1.3	-0.5	-0.8
Serious illness, injury or assault to yourself	0.3	0.3	0.6	0.3	-0.8	-0.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.6	0.8	-0.8	-0.0
Impedance of leg (left)	0.3	1.4	1.7	1.3	-1.1	-1.0
Waist circumference	0.3	1.1	2.9	-0.5	1.7	0.1
Forced vital capacity (FVC)	0.3	1.0	2.7	-0.0	1.6	0.6
Medication: Simvastatin	0.3	0.4	1.2	-1.1	-0.2	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.7	0.8	-0.4	-0.3
Medication: Cholesterol lowering	0.3	0.4	0.8	-0.9	-0.5	-0.4
Medication: Lansoprazole	0.3	0.3	0.8	0.9	-0.1	-0.1
Prospective memory result	0.3	0.3	0.6	-0.8	0.6	0.1
Number of full brothers	0.3	0.4	0.6	0.6	0.4	0.8
Health satisfaction	0.3	0.4	0.6	0.5	0.6	0.8
Had major operations	0.3	0.3	0.4	0.6	0.6	0.5
Loneliness, isolation	0.3	0.4	0.6	0.5	-0.5	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	-0.1	-0.9	-0.3
Osteoarthritis (self-reported)	0.3	0.4	0.6	-0.6	-0.5	-0.8
Number of operations (self-reported)	0.3	0.5	0.9	0.5	1.0	0.6
Irritability	0.3	0.6	1.4	0.5	-1.2	-0.2
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.9	-0.4	-0.4	-0.9
Fractured/broken bones in last 5 years	0.3	0.4	0.8	0.6	0.9	0.5
Unable to work because of sickness or disability	0.3	0.4	0.6	0.2	0.8	0.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.4	0.6	0.7	0.6
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	-0.3	0.9	0.1
Hair Pigment	0.2	6.6	12.8	-1.6	-3.6	-2.1
Relative age of first facial hair	0.2	0.4	0.6	-0.8	0.8	-0.0
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	-0.8	-0.1	-0.3
Vitamin and mineral supplements	0.2	0.2	0.4	-0.6	0.4	0.3
Severe depression (siblings)	0.2	0.3	0.7	0.8	-0.4	0.2
Impedance of leg (right)	0.2	0.8	1.6	1.2	-0.5	-0.8
Maternal smoking around birth	0.2	0.3	0.7	-0.8	-0.1	-0.2
Relative age voice broke	0.2	0.3	0.7	0.8	0.5	-0.1
Age when periods started (menarche)	0.2	0.6	0.8	-0.9	-0.9	-0.5
Medication: Levothyroxine sodium	0.2	0.3	0.5	-0.1	0.7	0.6
Mouth/teeth dental problems	0.2	0.3	0.4	0.1	0.6	0.7
Heart attack	0.2	0.3	0.8	-0.0	0.3	0.9
Worrier / anxious feelings	0.2	0.3	0.6	0.8	-0.5	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.7	-0.8	-0.4	-0.6
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	-0.5	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.6	-0.7	1.3	0.3
Noisy workplace	0.2	0.3	0.5	-0.2	-0.5	-0.7
Depression (self-reported)	0.2	0.2	0.6	0.2	-0.8	-0.2
Impedance of arm (left)	0.2	0.9	1.7	1.3	-0.1	0.9
Standing height	0.2	1.8	2.2	-1.5	1.3	-1.3
Length of working week for main job	0.2	0.3	0.4	-0.3	-0.6	-0.6
Exposure to tobacco smoke at home	0.2	0.2	0.5	-0.0	-0.7	-0.3
Breastfed as a baby	0.2	0.2	0.3	0.5	-0.6	0.1
Medication: Amlodipine	0.2	0.3	0.4	-0.6	-0.4	-0.6
Birth weight	0.2	0.3	0.8	-0.1	0.9	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.5	-0.2	-0.7	0.3
Age at first live birth	0.2	0.3	0.8	0.4	-0.2	-0.9
Shortness of breath walking on level ground	0.2	0.3	0.6	-0.2	0.3	0.8
Medication: Ibuprofen	0.2	0.2	0.6	0.8	-0.3	0.1
Medication: Omeprazole	0.2	0.2	0.4	0.7	0.4	0.4
Back pain experienced in last month	0.2	0.3	0.6	-0.8	-0.2	0.3
Smoking status: Current	0.2	0.4	0.7	0.7	0.8	0.2
Miserableness	0.2	0.3	0.6	-0.4	-0.8	0.2
Wears glasses or contact lenses	0.2	0.3	0.5	0.1	-0.6	-0.7
Medication: Paracetamol	0.2	0.3	0.5	-0.2	-0.5	-0.7
Leg fat percentage (left)	0.2	0.9	2.0	-0.7	1.4	0.4
Basal cell carcinoma (self-reported)	0.2	0.2	0.3	-0.3	-0.6	-0.4
Impedance of whole body	0.2	0.9	2.1	1.4	-0.8	0.0
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.6	0.7	-0.8	-0.4
HbA1C	0.1	0.1	0.2	-0.5	-0.0	-0.3
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.4	0.4	-0.3
Height	0.1	2.8	3.3	-1.8	1.4	-1.7
Waist Hip Ratio (WHR)	0.1	0.3	0.8	0.9	-0.0	-0.4
Lung FEV1/FVC ratio	0.1	0.4	0.8	-0.9	0.0	-0.7
Tanning	0.1	0.7	1.4	-0.8	1.2	0.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	-0.0	-0.5	-0.3
Angina	0.1	0.1	0.3	0.1	0.6	0.2
Medication: Co-codamol	0.1	0.1	0.2	-0.1	0.2	0.4
Medication: Metformin	0.1	0.2	0.4	0.6	0.2	0.4
Pack years adult smoking proportion	0.1	0.1	0.4	0.6	-0.1	0.2
Current tobacco smoking	0.1	0.2	0.7	0.1	0.8	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	0.5	-0.1	-0.1
Alcohol usually taken with meals	0.1	0.1	0.2	-0.4	0.1	0.4
Pain all over the body in last month	0.1	0.1	0.2	-0.1	0.2	0.4
Medication: Ramipril	0.1	0.2	0.3	-0.2	0.4	0.6
Fluid intelligence score	0.1	0.2	0.5	0.7	-0.3	0.1
Impedance of arm (right)	0.1	0.6	1.3	1.2	-0.5	0.4
Time employed in main current job	0.1	0.1	0.3	-0.5	-0.2	-0.1
Alcohol intake versus 10 years previously	0.1	0.2	0.3	0.5	0.5	0.2
Happiness	0.1	0.1	0.2	0.4	0.1	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.7	-0.8	0.0	-0.2
Mouth/teeth dental problems: Dentures	0.1	0.2	0.3	-0.1	-0.5	0.5
Illnesses of mother	0.1	0.1	0.2	-0.1	0.5	-0.0
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.3	0.4	0.2
Angina (self-reported)	0.1	0.1	0.4	-0.0	0.6	0.3
Medication: Seretide 50 evohaler	0.1	0.2	0.4	0.3	0.6	0.0
Heart disease (mother)	0.1	0.1	0.1	0.3	0.3	0.0
Comparative height size at age 10	0.1	0.4	0.7	0.4	0.9	-0.5
Overall health rating	0.1	0.2	0.4	-0.2	0.4	0.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.4	0.1	-0.1
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.3	0.4	0.0
Average weekly red wine intake	0.1	0.1	0.3	0.5	-0.1	-0.2
Long-standing illness, disability or infirmity	0.1	0.2	0.4	0.0	-0.4	-0.6
Hearing aid user	0.1	0.1	0.2	0.4	0.5	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	-0.2	-0.5	0.3
Medication: Lisinopril	0.1	0.2	0.5	-0.1	0.7	0.1
Age started oral contraceptive pill	0.1	0.1	0.4	0.0	-0.6	0.1
Commuting to job workplace: Cycle	0.1	0.2	0.2	-0.4	-0.5	-0.3
Pack years of smoking	0.1	0.1	0.1	0.3	-0.3	0.2
Blood White Count	0.0	0.0	0.0	0.0	0.0	0.1
Smoking Status	0.0	0.1	0.1	0.1	0.4	-0.3
Lung FVC	0.0	0.1	0.2	-0.2	0.5	0.3
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.1	-0.1	-0.3	0.1
Qualifications: CSEs or equivalent	0.0	0.0	0.1	0.4	-0.1	-0.0
Multivitamins +/- minerals	0.0	0.1	0.1	-0.4	-0.2	0.1
Supplements: Glucosamine	0.0	0.1	0.2	-0.1	0.0	-0.4
Neck or shoulder pain in last month	0.0	0.0	0.1	-0.2	-0.1	-0.2
Medication: Allopurinol	0.0	0.0	0.1	0.3	0.2	0.0
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	0.2	-0.3	-0.1
Cholesterol lowering medication	0.0	0.1	0.1	-0.2	0.3	0.1
Heart disease (siblings)	0.0	0.0	0.1	0.2	-0.1	-0.0

Hub : Genes

NAE1

Models

Trait associations