Hub : Genes

TPPP3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0390	0.0200	7.1e-04	0.034	0.028	0.023	0.028	0.019	4.3e-05	2.0e-04	7.3e-04	0.00023	0.0021
2	GTEx	Pancreas	0.2390	0.0870	6.0e-03	0.006	NA	-0.003	NA	0.005	1.6e-01	NA	4.4e-01	NA	0.2000
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0259	0.0139	4.7e-05	0.024	0.041	0.034	NA	0.030	8.2e-04	2.1e-05	9.7e-05	NA	0.0002

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.0	1.6	4.5	-0.0	-0.4	-2.1
Bipolar Disorder or Schizophrenia	2.0	4.9	12.6	-1.3	-0.8	-3.5
Depressed Affect (Nagel 2018)	1.2	2.5	6.2	-2.5	1.1	-0.2
Depression (Nagel 2018)	0.5	0.7	1.4	-1.2	0.7	0.5
Intelligence (Savage-Jansen 2018)	1.1	3.4	9.1	3.0	-0.0	1.1
Neuroticism (Nagel 2018)	0.9	2.0	4.7	-2.2	1.0	-0.6
Schizophrenia (2018)	1.8	3.8	8.0	-1.7	-0.6	-2.8
Schizophrenia vs Biploar Disorder	2.2	2.9	4.3	-2.0	2.1	-0.6
Worry (Nagel 2018)	0.5	1.0	1.3	-1.1	0.7	-1.1
Alzheimer’s Disease (in mother)	0.8	0.9	1.5	0.3	1.2	1.0
Alzheimer’s Disease (in father)	2.0	2.2	4.5	-0.7	-1.2	-2.1
Alzheimer’s Disease (including proxy)	0.1	0.1	0.1	-0.3	0.3	-0.2
Crohns Disease (2017)	2.1	4.6	9.2	3.0	-1.9	1.0
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	1.1	-0.5	0.3
Ulcerative Colitis (UC)	0.4	0.7	1.3	-1.1	0.7	-0.6
Major Depression (MDD)	1.4	1.6	4.4	0.2	2.1	-0.7
Reaction Time	0.6	1.2	2.2	0.9	0.7	1.5
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.1	0.8	1.0	0.1
Breast Cancer	0.9	2.2	2.7	1.3	-1.6	1.5
Ovarian Cancer	3.0	4.0	6.6	1.9	-1.3	2.6
Prostate Cancer	1.9	2.7	3.5	1.9	-1.1	1.9
Age at First Birth	3.6	5.2	9.2	3.0	-2.5	0.5
Bipolar Disorder (2011)	3.9	3.7	11.2	0.0	0.0	-3.3
Body Mass Index (BMI) (2010)	1.0	1.3	3.7	-0.1	-0.4	-1.9
Coronary Artery Disease (CAD)	0.7	0.9	2.1	0.6	-0.4	1.4
Crohns Disease (2012)	2.2	3.6	7.4	2.7	-1.4	1.2
Mean Putamen Volume	0.5	0.6	1.7	-0.2	-0.4	-1.3
Fasting Glucose	2.3	2.8	4.1	1.9	-0.8	2.0
HbA1C	0.2	0.2	0.7	0.8	0.0	-0.2
HDL Cholesterol	11.2	18.7	37.5	-6.1	3.6	-2.4
LDL Cholesterol	0.3	0.4	0.7	-0.5	0.8	-0.6
Lupus	0.2	0.3	0.6	-0.6	0.8	-0.0
Neuroticism (2016)	1.5	2.2	5.0	-2.2	1.0	-0.8
Primary Biliary Cirrhosis	0.6	0.9	1.4	-1.0	1.2	0.5
Rheumatoid Arthritis	0.5	0.7	1.2	-1.1	-0.4	-0.8
Schizophrenia (2014)	1.3	2.9	6.2	-1.5	-0.3	-2.5
Triglycerides	2.3	3.8	6.8	2.1	-2.6	0.3
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.6	0.6	-0.1	-0.8
Ulcerative Colitis	0.2	0.2	0.7	0.2	-0.8	0.2
Blood Eosinophil Count	3.3	25.5	44.2	-6.7	5.5	1.3
Blood Platelet Count	0.3	3.3	7.5	-0.2	1.5	2.7
Blood Red Count	2.1	20.2	51.3	-2.9	1.0	-7.2
Blood White Count	0.8	5.6	8.8	-0.5	2.8	3.0
Heel T-Score	8.9	70.4	156.2	7.0	-12.5	-2.4
BMI	0.7	4.1	7.5	-2.1	0.7	-2.7
Height	3.5	66.6	108.2	7.8	-5.5	10.4
Waist Hip Ratio (WHR)	3.4	15.4	40.5	2.2	1.0	6.4
Systolic Blood Pressure	0.1	0.7	1.7	0.7	1.3	-0.1
Smoking Status	0.1	0.2	0.3	-0.6	-0.4	0.3
Allergy or Eczema	0.1	0.4	0.6	0.4	0.8	0.6
Cardiovascular Disease	0.6	1.9	5.3	-0.2	2.3	0.7
Hypothyroidism (self reported)	7.3	16.8	38.7	-3.4	-0.1	-6.2
Respiratory disease	0.0	0.1	0.3	0.6	-0.1	0.0
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.8	-0.9	1.4	0.8
Lung FEV1/FVC ratio	7.5	37.8	65.1	-6.9	1.2	-8.1
Lung FVC	1.1	5.4	13.5	3.7	0.3	1.6
Neuroticism	1.3	3.2	7.1	-2.7	1.1	-1.1
Chronotype (morning person)	1.4	3.2	5.2	1.4	-1.6	2.3
Hair Pigment	0.1	4.3	11.2	-1.3	0.1	-3.3
Tanning	0.1	0.6	1.6	-1.3	-0.5	0.0
Hand grip strength (left)	0.4	1.0	2.0	-0.1	-1.4	-1.1
Number of treatments/medications taken	1.1	2.1	4.0	-2.0	1.4	-0.3
Average weekly spirits intake	1.2	1.4	3.2	0.8	-0.6	1.8
Sensitivity / hurt feelings	0.2	0.3	0.6	-0.8	0.1	0.4
Frequency of depressed mood in last 2 weeks	0.9	1.2	2.9	-1.7	0.1	-0.8
Hearing difficulty/problems: Yes	0.2	0.3	1.0	-0.2	0.1	-1.0
Relative age of first facial hair	0.2	0.5	0.8	0.8	-0.9	0.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.3	0.0	1.1	0.5
Ever used hormone-replacement therapy (HRT)	2.5	3.2	4.1	2.0	-2.0	1.2
Ever had hysterectomy (womb removed)	0.6	0.7	1.7	0.6	0.2	1.3
Systolic blood pressure, automated reading	0.2	0.6	1.4	0.5	1.2	-0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.3	0.5	0.5
Angina	0.2	0.3	0.5	0.6	-0.7	0.2
Medication for hormone replacement therapy	0.4	0.4	0.8	0.2	0.9	0.6
Vitamin and mineral supplements	0.3	0.4	1.1	1.1	0.0	0.4
Supplements: Zinc	0.8	0.8	1.2	-1.1	-0.3	-1.1
Medication: Co-codamol	0.4	0.4	0.6	-0.8	0.1	-0.8
Medication: Metformin	0.1	0.2	0.2	-0.5	-0.1	-0.5
Diabetes (father)	2.8	3.4	6.0	-1.8	2.4	-1.0
Diabetes (mother)	1.4	1.8	3.5	-1.4	-1.9	-0.0
Severe depression (siblings)	2.4	2.7	4.4	-2.1	1.9	-0.1
Pack years adult smoking proportion	0.8	1.3	3.7	0.2	-0.2	1.9
Impedance of leg (right)	1.9	9.3	26.7	0.8	0.8	5.2
Leg fat-free mass (left)	0.9	4.8	7.9	2.4	-2.8	0.9
Trunk fat percentage	0.6	2.3	3.0	-1.6	1.7	1.2
Hand grip strength (right)	0.2	0.5	1.0	0.2	-0.7	-1.0
Townsend deprivation index at recruitment	0.0	0.0	0.1	-0.3	-0.0	0.0
Current tobacco smoking	1.1	1.7	3.7	-1.2	0.2	1.9
Average weekly fortified wine intake	0.2	0.2	0.2	0.3	0.5	0.5
Maternal smoking around birth	0.9	1.3	2.0	0.6	-1.2	1.4
Fed-up feelings	2.4	4.3	9.2	-3.0	1.6	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.7	-1.3	0.9	-0.3
Relative age voice broke	0.2	0.2	0.5	-0.1	-0.5	-0.7
Taking other prescription medications	0.2	0.3	0.8	-0.9	0.0	-0.2
Age when periods started (menarche)	0.2	0.5	1.1	1.1	0.5	0.2
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	1.2	-0.5	1.1	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	8.3	18.7	40.4	4.0	-6.4	-0.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.3	0.4	-0.2
Qualifications: CSEs or equivalent	4.1	5.4	12.9	-1.8	0.4	-3.6
Serious illness, injury or assault to yourself	4.3	5.2	9.2	2.4	-0.7	3.0
High blood pressure	0.5	1.4	3.9	0.6	2.0	0.3
Hayfever, allergic rhinitis or eczema	0.6	1.2	1.9	-1.2	1.4	-0.6
Multivitamins +/- minerals	0.3	0.4	0.5	-0.7	-0.4	-0.7
Stomach or abdominal pain in last month	1.8	2.2	3.6	-1.9	1.1	-1.3
Supplements: Glucosamine	0.9	1.2	1.7	1.2	-0.7	1.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.0	-1.0	0.3	0.0
Medication: Atenolol	0.7	0.9	2.0	0.8	1.4	0.2
Medication: Levothyroxine sodium	5.1	8.6	20.5	-2.2	-0.4	-4.5
Sitting height	5.5	39.2	59.0	7.7	-6.5	4.1
Chronic bronchitis/emphysema (father)	0.3	0.4	0.8	0.3	-0.9	0.5
High blood pressure (mother)	0.8	1.1	2.6	-0.7	0.5	-1.6
Body mass index (BMI)	0.6	2.7	3.8	-1.9	0.8	-1.9
Impedance of leg (left)	1.8	8.9	25.1	0.3	1.2	5.0
Leg predicted mass (left)	0.9	4.9	8.0	2.4	-2.8	1.0
Trunk fat mass	0.3	1.4	4.1	-0.2	0.3	2.0
Waist circumference	0.8	3.1	8.3	1.0	-0.0	2.9
Number of incorrect matches in round	1.2	2.0	2.3	-1.2	1.5	1.4
Past tobacco smoking	0.5	0.9	1.6	-1.1	1.2	0.2
Alcohol usually taken with meals	2.2	3.6	8.2	-1.6	0.2	-2.9
Nervous feelings	1.1	2.0	4.5	-0.8	0.9	-2.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.6	-1.3	-0.1	-0.3
Hearing difficulty/problems with background noise	0.1	0.1	0.3	0.1	0.6	-0.1
Hair/balding pattern: Pattern 2	2.2	2.9	4.6	2.2	-1.9	0.5
Had menopause	0.2	0.2	0.6	-0.2	0.2	0.8
Had other major operations	2.9	3.6	7.1	-2.7	1.4	-1.3
Forced vital capacity (FVC)	2.8	10.9	17.4	4.2	-0.9	3.8
Heel bone mineral density (BMD) T-score, automated (right)	8.4	19.2	40.9	4.1	-6.4	-0.2
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.6	-0.5	1.6	0.3
Qualifications: None of the above	0.6	1.3	3.2	-1.8	0.7	0.4
Financial difficulties in last 2 years	2.4	3.3	4.7	-2.0	2.2	1.1
Mouth/teeth dental problems	1.2	1.8	4.7	-0.7	2.2	-0.5
Heart attack	0.3	0.4	0.9	-0.5	-0.9	-0.4
Allergy	0.8	1.8	3.2	1.2	-1.8	0.8
Pain all over the body in last month	0.2	0.2	0.5	-0.7	0.3	-0.1
Diabetes (self-reported)	0.4	0.6	1.2	-0.5	1.1	0.5
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.6	0.3	-0.4	1.6
Medication: Ramipril	0.0	0.1	0.2	-0.0	0.1	0.4
Medication: Simvastatin	0.0	0.0	0.0	0.2	-0.1	0.2
Fluid intelligence score	0.7	1.5	2.8	1.7	0.1	1.2
Illnesses of siblings	0.6	0.8	1.2	-0.5	-1.1	-1.0
Neuroticism score	2.3	4.8	10.1	-3.2	1.5	-1.4
Weight	0.5	2.6	3.9	1.3	-1.4	2.0
Impedance of arm (right)	1.3	6.1	10.6	-1.3	3.2	2.5
Arm fat percentage (right)	0.8	3.2	5.3	-2.3	1.9	-0.9
Trunk fat-free mass	3.4	19.3	24.4	4.9	-4.9	3.1
Hip circumference	0.1	0.5	1.2	0.4	-1.1	0.3
Time employed in main current job	2.9	3.4	7.0	1.0	-2.6	-1.4
Alcohol intake versus 10 years previously	2.4	3.6	8.6	1.3	-0.7	2.9
Father’s age at death	0.4	0.5	1.5	-0.2	0.1	-1.2
Worrier / anxious feelings	0.1	0.2	0.4	-0.4	0.7	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.6	0.1	0.5
Falls in the last year	3.9	5.3	7.7	2.7	-1.0	2.8
Hair/balding pattern: Pattern 3	1.0	1.6	4.3	-0.6	0.2	-2.1
Number of live births	1.7	2.5	4.6	-2.2	-0.9	-1.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.0	1.4	-0.1	0.4
Pulse rate	0.6	1.0	2.1	0.7	0.7	1.5
Happiness	2.1	2.6	6.9	0.9	0.3	2.6
Noisy workplace	0.2	0.2	0.3	0.3	-0.5	0.5
Qualifications: A levels/AS levels or equivalent	1.8	3.9	6.2	2.5	-1.4	1.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.5	-0.5	0.7	0.7
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	-0.7	0.1	0.2
Asthma	0.4	0.7	1.5	1.2	-0.9	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	-1.2	0.2	-0.2
Medication: Cholesterol lowering	0.3	0.5	1.3	-0.5	0.2	-1.1
Depression (self-reported)	0.1	0.1	0.3	-0.6	0.3	0.1
Medication: Lansoprazole	0.4	0.5	0.9	-0.6	1.0	0.2
Prospective memory result	0.6	0.8	2.1	-1.4	0.2	-0.4
Lung cancer (father)	0.5	0.6	0.9	-0.9	0.9	-0.2
Illnesses of mother	0.5	0.6	1.4	0.7	-1.2	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.8	0.9	-0.3	0.2
Pulse wave Arterial Stiffness index	0.3	0.3	0.5	0.4	-0.7	0.5
Impedance of arm (left)	1.3	5.9	11.2	-1.6	3.3	2.1
Arm fat mass (right)	0.1	0.3	0.6	-0.8	0.4	0.3
Trunk predicted mass	3.5	19.8	24.9	5.0	-4.9	3.2
Standing height	5.0	49.8	73.6	7.1	-5.0	8.6
Length of working week for main job	0.3	0.3	0.4	-0.6	0.3	0.6
Exposure to tobacco smoke at home	0.4	0.4	0.7	-0.8	0.7	0.3
Breastfed as a baby	3.0	3.8	4.9	-1.5	2.2	-2.0
Tense / ‘highly strung’	0.5	0.8	1.7	-1.3	0.4	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.4	0.1	0.5
Hair/balding pattern: Pattern 4	10.0	24.3	47.5	2.0	4.6	6.9
Birth weight of first child	2.8	5.1	12.1	1.7	-3.5	-0.6
Peak expiratory flow (PEF)	0.3	0.7	1.9	0.5	0.3	-1.4
Pulse wave reflection index	0.4	0.4	1.0	0.4	-1.0	-0.5
Ever highly irritable/argumentative for 2 days	2.1	2.5	6.0	0.2	1.2	2.5
Loud music exposure frequency	0.5	0.5	1.3	-0.6	1.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.8	0.8	-0.9	-0.0
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	1.5	1.0	-1.2	1.2
Blood clot in the leg (DVT)	2.7	3.5	5.0	-1.9	2.2	-1.4
Medication: Paracetamol	1.2	2.0	5.8	0.2	0.2	2.4
Headache pain in last month	0.9	1.5	2.5	-1.6	1.3	0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.9	-1.0	-0.1	0.4
Glaucoma (self-reported)	1.2	1.4	3.3	-0.2	1.8	0.9
Gout (self-reported)	1.8	2.5	3.5	-1.9	1.4	-1.4
Hypothyroidism/myxoedema (self-reported)	6.3	12.2	27.0	-3.1	-0.3	-5.2
Medication: Amlodipine	1.0	1.4	2.2	0.1	1.5	-1.4
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.2	-0.4	-0.1	-1.5
Birth weight	5.7	12.3	20.4	3.1	-4.5	2.6
Chronic bronchitis/emphysema (mother)	4.1	4.8	9.3	-3.0	0.8	-2.1
High blood pressure (siblings)	0.4	0.5	1.3	1.2	0.5	0.2
Forced vital capacity (FVC), Best measure	1.5	5.4	8.5	2.9	-0.4	2.7
Body fat percentage	0.6	2.4	3.5	-1.9	1.7	0.9
Leg fat percentage (right)	0.4	1.6	2.7	-1.6	1.1	1.0
Arm fat-free mass (right)	2.3	11.9	16.7	3.6	-4.1	2.4
Exposure to tobacco smoke outside home	0.5	0.7	1.4	0.3	-0.8	1.2
Comparative body size at age 10	0.7	1.9	5.7	-2.4	0.1	-0.1
Number of full brothers	0.2	0.3	0.5	-0.7	0.5	0.0
Worry too long after embarrassment	0.2	0.3	0.8	0.1	-0.9	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	1.9	1.4	-0.8	1.4
Wheeze or whistling in the chest in last year	0.5	0.9	2.1	-1.4	0.7	0.2
Number of children fathered	1.2	1.4	3.0	1.7	-1.1	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.5	-0.4	1.2	-0.0
Age at first live birth	0.8	1.4	4.0	2.0	-0.1	-0.5
Pulse wave peak to peak time	0.1	0.1	0.2	0.1	0.4	0.3
Health satisfaction	0.6	0.7	1.6	0.2	0.8	1.3
Shortness of breath walking on level ground	0.9	1.1	2.5	-0.8	1.6	0.5
Qualifications: College or University degree	3.0	9.4	16.9	4.1	-1.7	2.9
Eye problems/disorders: None of the above	1.9	2.2	4.6	1.3	-2.1	0.7
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.5	1.0	-1.2	0.6
Emphysema/chronic bronchitis	0.4	0.5	1.0	-0.1	0.6	1.0
Medication for pain relief, constipation, heartburn	0.9	1.5	2.6	1.2	-0.6	-1.6
Neck or shoulder pain in last month	1.0	1.4	1.7	-1.3	-1.2	-1.0
Medication: Blood pressure	0.9	1.5	4.3	2.1	-0.3	0.5
Angina (self-reported)	0.1	0.2	0.4	0.3	-0.6	-0.2
Migraine (self-reported)	1.4	1.8	3.2	-1.2	1.8	-0.9
Medication: Ibuprofen	1.7	2.0	4.4	-2.1	0.7	-1.1
Medication: Allopurinol	0.1	0.1	0.2	-0.4	0.2	-0.4
Medication: Omeprazole	1.3	1.5	4.0	-0.6	0.4	2.0
Medication: Seretide 50 evohaler	1.6	1.9	4.5	1.0	-0.5	2.1
Mean time to correctly identify matches	0.4	0.7	1.2	1.1	-0.1	1.0
Heart disease (mother)	0.9	1.1	2.3	-1.0	1.5	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	0.9	-0.5	-0.7	-1.0
Whole body fat mass	0.2	0.9	2.2	-0.6	0.3	1.5
Leg fat mass (right)	0.2	0.8	2.0	-0.6	0.3	1.4
Arm predicted mass (right)	2.1	10.9	14.4	3.6	-3.8	2.4
Pulse rate, automated reading	1.1	3.4	5.9	1.1	2.4	1.8
Alcohol intake frequency.	1.2	2.8	5.4	-2.3	0.7	-1.5
Comparative height size at age 10	3.5	19.5	43.2	3.4	-1.9	6.6
Number of full sisters	0.4	0.5	0.9	-0.1	0.7	0.9
Suffer from ‘nerves’	3.2	5.0	7.9	-2.5	0.8	-2.8
Overall health rating	0.4	0.9	1.6	-0.3	1.3	1.0
Chest pain or discomfort	0.1	0.1	0.2	-0.5	0.2	-0.4
Had major operations	0.4	0.4	0.7	-0.6	0.9	0.4
Age at last live birth	0.3	0.4	1.0	0.3	1.0	0.1
Family relationship satisfaction	4.0	4.9	10.0	1.9	-1.0	3.2
Leg pain on walking	0.9	1.1	3.2	-0.1	0.2	1.8
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.2	0.1	-0.0	1.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.1	-0.7	-0.5
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	0.8	0.8	-0.5	-0.9
Medication: Aspirin	0.8	1.0	2.0	-1.0	1.4	0.4
Supplements: Vitamin C	0.9	1.0	1.5	-1.2	0.8	-0.9
Knee pain experienced in last month	0.5	0.8	1.4	-1.2	-0.9	-0.3
Hypertension (Self-reported)	0.4	1.1	3.1	0.4	1.8	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.5	0.1	0.4	1.2
Illnesses of father: Heart disease	0.3	0.4	0.7	0.8	-0.2	0.5
Illnesses of siblings: Diabetes	1.7	2.1	4.0	-2.0	1.0	-1.1
Smoking status: Previous	1.5	2.2	3.1	1.4	-1.8	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	3.5	1.6	-1.9	1.6
Whole body fat-free mass	2.3	12.9	17.6	4.0	-4.2	2.3
Leg fat-free mass (right)	0.8	4.4	7.7	2.3	-2.8	0.7
Arm fat percentage (left)	1.0	4.1	6.9	-2.6	2.1	-0.9
Average weekly red wine intake	0.6	0.8	1.8	-0.2	-1.3	0.8
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	0.3	0.4	0.7
Mood swings	1.8	3.2	7.3	-2.7	0.9	-1.2
Loneliness, isolation	1.5	2.1	5.7	-2.4	0.8	-0.2
Long-standing illness, disability or infirmity	1.1	1.6	2.5	1.5	-0.4	1.6
Ever had bowel cancer screening	0.1	0.2	0.2	0.4	0.4	0.5
Diabetes diagnosed by doctor	0.6	1.0	1.9	-0.8	1.4	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.4	0.4	0.2	1.2
Friendships satisfaction	2.2	2.7	6.8	1.2	0.0	2.6
Qualifications: nursing, teaching	0.3	0.4	1.3	-0.2	-0.1	-1.1
Commuting to job workplace: Walk	0.1	0.2	0.4	0.7	-0.2	0.1
Eye problems/disorders: Cataract	1.8	2.1	4.1	-1.2	2.0	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.1	0.7	-1.5	-0.7
Medication for cholesterol	2.0	3.0	8.3	0.3	-2.9	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	4.6	0.2	-0.6	2.1
Back pain experienced in last month	0.2	0.3	0.7	-0.9	-0.2	-0.0
Mineral and other dietary supplements	0.3	0.4	0.6	-0.1	0.8	-0.8
Breast cancer (self-reported)	2.9	3.5	4.8	-2.0	2.2	-1.3
Asthma (self-reported)	0.3	0.6	1.5	1.2	-0.6	0.2
Osteoporosis (self-reported)	2.4	2.9	6.1	-1.4	2.5	0.9
Osteoarthritis (self-reported)	0.2	0.2	0.4	-0.0	-0.4	-0.6
Medication: Aspirin	1.1	1.5	2.5	-1.4	1.6	0.2
Medication: Gliclazide	0.6	0.7	0.8	-0.9	0.7	-0.8
Illnesses of father: None of the above (group 1)	0.4	0.5	1.2	-1.1	0.4	-0.2
Smoking status: Current	1.3	2.0	3.2	-1.5	0.7	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.0	0.4	-0.4	-1.4
Whole body water mass	2.2	12.7	18.2	3.9	-4.3	2.1
Leg predicted mass (right)	0.9	4.6	7.9	2.3	-2.8	0.7
Arm fat mass (left)	0.1	0.2	0.4	-0.6	0.3	0.4
Number of self-reported non-cancer illnesses	0.3	0.6	1.1	0.4	1.0	0.7
Average weekly champagne plus white wine intake	2.9	4.0	6.3	-2.5	1.7	-1.6
Miserableness	0.9	1.6	2.9	-1.7	1.3	-0.4
Guilty feelings	0.8	1.2	3.3	-1.8	0.5	0.2
Wears glasses or contact lenses	0.0	0.0	0.1	0.3	0.1	0.1
Ever taken oral contraceptive pill	2.1	2.3	5.9	0.9	-2.4	-0.5
Hearing aid user	0.1	0.1	0.2	-0.1	-0.4	0.2
Mother’s age at death	0.4	0.6	1.1	1.1	-0.5	0.5
Financial situation satisfaction	0.9	1.1	3.1	-0.3	-0.2	1.8
Tinnitus: Yes, now most or all of the time	1.4	1.7	3.5	-1.0	0.7	-1.9
Commuting to job workplace: Public transport	1.1	1.3	2.4	1.5	-0.0	1.2
Eye problems/disorders: Glaucoma	0.8	1.0	2.6	-0.2	1.6	0.5
Medication: Blood pressure	2.0	3.8	10.7	-0.9	3.3	-0.2
Pain type(s) experienced in last month: Hip pain	0.9	1.2	1.7	-1.3	-0.2	-1.3
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.1	-0.6	-1.1	-0.3
High cholesterol (Self-reported)	0.4	0.6	1.2	-0.8	1.1	-0.3
Medication: Bendroflumethiazide	1.6	2.4	3.4	1.0	1.9	1.7
Medication: Paracetamol	0.6	0.9	2.5	-0.2	-0.2	1.6
Medication: Lisinopril	0.5	0.7	1.4	0.0	0.8	1.2
Medication: Atorvastatin	0.4	0.5	0.8	-0.1	0.7	0.9
Illnesses of father: High blood pressure	2.2	2.8	4.1	-0.9	2.0	-1.8
Alcohol drinker status: Never	0.5	0.6	1.5	-1.2	0.4	-0.2
Ever smoked	0.1	0.1	0.3	-0.0	-0.4	-0.5
Basal metabolic rate	1.9	10.5	13.5	3.5	-3.7	2.4
Leg fat percentage (left)	0.5	1.9	3.4	-1.8	1.3	0.7
Arm fat-free mass (left)	2.6	13.1	16.1	4.0	-4.0	2.7
Number of operations (self-reported)	0.8	1.2	2.5	-1.0	0.3	-1.6
Average weekly beer plus cider intake	1.0	1.4	1.7	1.0	-1.3	1.3
Irritability	2.4	4.0	7.7	-2.8	1.4	-1.6
Risk taking	1.5	2.2	4.4	1.3	-0.8	2.1
Ever had prostate specific antigen (PSA) test	3.9	4.5	9.7	2.0	-3.1	0.0
Fractured/broken bones in last 5 years	1.4	1.9	3.1	0.3	1.5	1.8
Age started oral contraceptive pill	0.2	0.3	0.7	-0.2	0.8	-0.4
Diastolic blood pressure, automated reading	0.6	1.9	5.3	-0.2	2.3	-0.5
Ever depressed for a whole week	0.9	1.1	2.3	-1.0	1.5	0.3
Unable to work because of sickness or disability	0.1	0.2	0.4	-0.2	0.4	0.6
Commuting to job workplace: Cycle	0.4	0.4	1.3	0.1	-1.1	0.1
Myopia	1.2	1.7	4.4	-0.3	0.7	-2.1
Vascular/heart problems diagnosed by doctor	0.5	1.5	4.1	-0.3	-2.0	-0.4
Cholesterol lowering medication	0.5	0.8	1.4	-0.5	1.2	0.8
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.6	-0.8	0.7	1.9
Pain experienced in last month	0.8	1.3	3.5	1.9	-0.5	-0.5
Supplements: Calcium	0.3	0.3	0.6	-0.3	0.6	-0.7
Basal cell carcinoma (self-reported)	0.3	0.3	0.6	0.8	-0.6	0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.0	-0.5	-1.0	-0.3
Deep venous thrombosis (DVT) (self-reported)	3.5	4.6	6.5	-2.2	2.5	-1.5
Heart disease (siblings)	0.6	0.7	1.5	0.8	-0.2	1.2
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.6	-0.0	-0.3
Pack years of smoking	0.8	1.2	3.4	0.3	-0.3	1.9
Impedance of whole body	1.5	7.6	15.8	-0.5	2.6	4.0
Leg fat mass (left)	0.2	0.6	1.5	-0.6	0.2	1.2
Arm predicted mass (left)	2.7	13.7	16.6	4.1	-4.1	2.8