Hub : Genes

TPPP3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0390 0.0200 7.1e-04 0.034 0.028 0.023 0.028 0.019 4.3e-05 2.0e-04 7.3e-04 0.00023 0.0021
2 GTEx Pancreas 0.2390 0.0870 6.0e-03 0.006 NA -0.003 NA 0.005 1.6e-01 NA 4.4e-01 NA 0.2000
3 TCGA Kidney Renal Clear Cell Carcinoma 0.0259 0.0139 4.7e-05 0.024 0.041 0.034 NA 0.030 8.2e-04 2.1e-05 9.7e-05 NA 0.0002

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.0 1.6 4.5 -0.0 -0.4 -2.1
Bipolar Disorder or Schizophrenia 2.0 4.9 12.6 -1.3 -0.8 -3.5
Depressed Affect (Nagel 2018) 1.2 2.5 6.2 -2.5 1.1 -0.2
Depression (Nagel 2018) 0.5 0.7 1.4 -1.2 0.7 0.5
Intelligence (Savage-Jansen 2018) 1.1 3.4 9.1 3.0 -0.0 1.1
Neuroticism (Nagel 2018) 0.9 2.0 4.7 -2.2 1.0 -0.6
Schizophrenia (2018) 1.8 3.8 8.0 -1.7 -0.6 -2.8
Schizophrenia vs Biploar Disorder 2.2 2.9 4.3 -2.0 2.1 -0.6
Worry (Nagel 2018) 0.5 1.0 1.3 -1.1 0.7 -1.1
Alzheimer’s Disease (in mother) 0.8 0.9 1.5 0.3 1.2 1.0
Alzheimer’s Disease (in father) 2.0 2.2 4.5 -0.7 -1.2 -2.1
Alzheimer’s Disease (including proxy) 0.1 0.1 0.1 -0.3 0.3 -0.2
Crohns Disease (2017) 2.1 4.6 9.2 3.0 -1.9 1.0
Irritable Bowel Disease (IBD) 0.2 0.5 1.2 1.1 -0.5 0.3
Ulcerative Colitis (UC) 0.4 0.7 1.3 -1.1 0.7 -0.6
Major Depression (MDD) 1.4 1.6 4.4 0.2 2.1 -0.7
Reaction Time 0.6 1.2 2.2 0.9 0.7 1.5
Verbal and Numeric Reasoning (VNR) 0.2 0.6 1.1 0.8 1.0 0.1
Breast Cancer 0.9 2.2 2.7 1.3 -1.6 1.5
Ovarian Cancer 3.0 4.0 6.6 1.9 -1.3 2.6
Prostate Cancer 1.9 2.7 3.5 1.9 -1.1 1.9
Age at First Birth 3.6 5.2 9.2 3.0 -2.5 0.5
Bipolar Disorder (2011) 3.9 3.7 11.2 0.0 0.0 -3.3
Body Mass Index (BMI) (2010) 1.0 1.3 3.7 -0.1 -0.4 -1.9
Coronary Artery Disease (CAD) 0.7 0.9 2.1 0.6 -0.4 1.4
Crohns Disease (2012) 2.2 3.6 7.4 2.7 -1.4 1.2
Mean Putamen Volume 0.5 0.6 1.7 -0.2 -0.4 -1.3
Fasting Glucose 2.3 2.8 4.1 1.9 -0.8 2.0
HbA1C 0.2 0.2 0.7 0.8 0.0 -0.2
HDL Cholesterol 11.2 18.7 37.5 -6.1 3.6 -2.4
LDL Cholesterol 0.3 0.4 0.7 -0.5 0.8 -0.6
Lupus 0.2 0.3 0.6 -0.6 0.8 -0.0
Neuroticism (2016) 1.5 2.2 5.0 -2.2 1.0 -0.8
Primary Biliary Cirrhosis 0.6 0.9 1.4 -1.0 1.2 0.5
Rheumatoid Arthritis 0.5 0.7 1.2 -1.1 -0.4 -0.8
Schizophrenia (2014) 1.3 2.9 6.2 -1.5 -0.3 -2.5
Triglycerides 2.3 3.8 6.8 2.1 -2.6 0.3
Type 2 Diabetes (T2D) (2012) 0.3 0.3 0.6 0.6 -0.1 -0.8
Ulcerative Colitis 0.2 0.2 0.7 0.2 -0.8 0.2
Blood Eosinophil Count 3.3 25.5 44.2 -6.7 5.5 1.3
Blood Platelet Count 0.3 3.3 7.5 -0.2 1.5 2.7
Blood Red Count 2.1 20.2 51.3 -2.9 1.0 -7.2
Blood White Count 0.8 5.6 8.8 -0.5 2.8 3.0
Heel T-Score 8.9 70.4 156.2 7.0 -12.5 -2.4
BMI 0.7 4.1 7.5 -2.1 0.7 -2.7
Height 3.5 66.6 108.2 7.8 -5.5 10.4
Waist Hip Ratio (WHR) 3.4 15.4 40.5 2.2 1.0 6.4
Systolic Blood Pressure 0.1 0.7 1.7 0.7 1.3 -0.1
Smoking Status 0.1 0.2 0.3 -0.6 -0.4 0.3
Allergy or Eczema 0.1 0.4 0.6 0.4 0.8 0.6
Cardiovascular Disease 0.6 1.9 5.3 -0.2 2.3 0.7
Hypothyroidism (self reported) 7.3 16.8 38.7 -3.4 -0.1 -6.2
Respiratory disease 0.0 0.1 0.3 0.6 -0.1 0.0
Type 2 Diabetes (T2D) (2018) 0.6 1.1 1.8 -0.9 1.4 0.8
Lung FEV1/FVC ratio 7.5 37.8 65.1 -6.9 1.2 -8.1
Lung FVC 1.1 5.4 13.5 3.7 0.3 1.6
Neuroticism 1.3 3.2 7.1 -2.7 1.1 -1.1
Chronotype (morning person) 1.4 3.2 5.2 1.4 -1.6 2.3
Hair Pigment 0.1 4.3 11.2 -1.3 0.1 -3.3
Tanning 0.1 0.6 1.6 -1.3 -0.5 0.0
Hand grip strength (left) 0.4 1.0 2.0 -0.1 -1.4 -1.1
Number of treatments/medications taken 1.1 2.1 4.0 -2.0 1.4 -0.3
Average weekly spirits intake 1.2 1.4 3.2 0.8 -0.6 1.8
Sensitivity / hurt feelings 0.2 0.3 0.6 -0.8 0.1 0.4
Frequency of depressed mood in last 2 weeks 0.9 1.2 2.9 -1.7 0.1 -0.8
Hearing difficulty/problems: Yes 0.2 0.3 1.0 -0.2 0.1 -1.0
Relative age of first facial hair 0.2 0.5 0.8 0.8 -0.9 0.4
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.3 0.0 1.1 0.5
Ever used hormone-replacement therapy (HRT) 2.5 3.2 4.1 2.0 -2.0 1.2
Ever had hysterectomy (womb removed) 0.6 0.7 1.7 0.6 0.2 1.3
Systolic blood pressure, automated reading 0.2 0.6 1.4 0.5 1.2 -0.4
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.3 -0.3 0.5 0.5
Angina 0.2 0.3 0.5 0.6 -0.7 0.2
Medication for hormone replacement therapy 0.4 0.4 0.8 0.2 0.9 0.6
Vitamin and mineral supplements 0.3 0.4 1.1 1.1 0.0 0.4
Supplements: Zinc 0.8 0.8 1.2 -1.1 -0.3 -1.1
Medication: Co-codamol 0.4 0.4 0.6 -0.8 0.1 -0.8
Medication: Metformin 0.1 0.2 0.2 -0.5 -0.1 -0.5
Diabetes (father) 2.8 3.4 6.0 -1.8 2.4 -1.0
Diabetes (mother) 1.4 1.8 3.5 -1.4 -1.9 -0.0
Severe depression (siblings) 2.4 2.7 4.4 -2.1 1.9 -0.1
Pack years adult smoking proportion 0.8 1.3 3.7 0.2 -0.2 1.9
Impedance of leg (right) 1.9 9.3 26.7 0.8 0.8 5.2
Leg fat-free mass (left) 0.9 4.8 7.9 2.4 -2.8 0.9
Trunk fat percentage 0.6 2.3 3.0 -1.6 1.7 1.2
Hand grip strength (right) 0.2 0.5 1.0 0.2 -0.7 -1.0
Townsend deprivation index at recruitment 0.0 0.0 0.1 -0.3 -0.0 0.0
Current tobacco smoking 1.1 1.7 3.7 -1.2 0.2 1.9
Average weekly fortified wine intake 0.2 0.2 0.2 0.3 0.5 0.5
Maternal smoking around birth 0.9 1.3 2.0 0.6 -1.2 1.4
Fed-up feelings 2.4 4.3 9.2 -3.0 1.6 -1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 1.7 -1.3 0.9 -0.3
Relative age voice broke 0.2 0.2 0.5 -0.1 -0.5 -0.7
Taking other prescription medications 0.2 0.3 0.8 -0.9 0.0 -0.2
Age when periods started (menarche) 0.2 0.5 1.1 1.1 0.5 0.2
Bilateral oophorectomy (both ovaries removed) 0.7 0.9 1.2 -0.5 1.1 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 8.3 18.7 40.4 4.0 -6.4 -0.3
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 0.3 0.4 -0.2
Qualifications: CSEs or equivalent 4.1 5.4 12.9 -1.8 0.4 -3.6
Serious illness, injury or assault to yourself 4.3 5.2 9.2 2.4 -0.7 3.0
High blood pressure 0.5 1.4 3.9 0.6 2.0 0.3
Hayfever, allergic rhinitis or eczema 0.6 1.2 1.9 -1.2 1.4 -0.6
Multivitamins +/- minerals 0.3 0.4 0.5 -0.7 -0.4 -0.7
Stomach or abdominal pain in last month 1.8 2.2 3.6 -1.9 1.1 -1.3
Supplements: Glucosamine 0.9 1.2 1.7 1.2 -0.7 1.3
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.0 -1.0 0.3 0.0
Medication: Atenolol 0.7 0.9 2.0 0.8 1.4 0.2
Medication: Levothyroxine sodium 5.1 8.6 20.5 -2.2 -0.4 -4.5
Sitting height 5.5 39.2 59.0 7.7 -6.5 4.1
Chronic bronchitis/emphysema (father) 0.3 0.4 0.8 0.3 -0.9 0.5
High blood pressure (mother) 0.8 1.1 2.6 -0.7 0.5 -1.6
Body mass index (BMI) 0.6 2.7 3.8 -1.9 0.8 -1.9
Impedance of leg (left) 1.8 8.9 25.1 0.3 1.2 5.0
Leg predicted mass (left) 0.9 4.9 8.0 2.4 -2.8 1.0
Trunk fat mass 0.3 1.4 4.1 -0.2 0.3 2.0
Waist circumference 0.8 3.1 8.3 1.0 -0.0 2.9
Number of incorrect matches in round 1.2 2.0 2.3 -1.2 1.5 1.4
Past tobacco smoking 0.5 0.9 1.6 -1.1 1.2 0.2
Alcohol usually taken with meals 2.2 3.6 8.2 -1.6 0.2 -2.9
Nervous feelings 1.1 2.0 4.5 -0.8 0.9 -2.1
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.6 -1.3 -0.1 -0.3
Hearing difficulty/problems with background noise 0.1 0.1 0.3 0.1 0.6 -0.1
Hair/balding pattern: Pattern 2 2.2 2.9 4.6 2.2 -1.9 0.5
Had menopause 0.2 0.2 0.6 -0.2 0.2 0.8
Had other major operations 2.9 3.6 7.1 -2.7 1.4 -1.3
Forced vital capacity (FVC) 2.8 10.9 17.4 4.2 -0.9 3.8
Heel bone mineral density (BMD) T-score, automated (right) 8.4 19.2 40.9 4.1 -6.4 -0.2
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 2.6 -0.5 1.6 0.3
Qualifications: None of the above 0.6 1.3 3.2 -1.8 0.7 0.4
Financial difficulties in last 2 years 2.4 3.3 4.7 -2.0 2.2 1.1
Mouth/teeth dental problems 1.2 1.8 4.7 -0.7 2.2 -0.5
Heart attack 0.3 0.4 0.9 -0.5 -0.9 -0.4
Allergy 0.8 1.8 3.2 1.2 -1.8 0.8
Pain all over the body in last month 0.2 0.2 0.5 -0.7 0.3 -0.1
Diabetes (self-reported) 0.4 0.6 1.2 -0.5 1.1 0.5
Hayfever/allergic rhinitis (self-reported) 0.7 1.0 2.6 0.3 -0.4 1.6
Medication: Ramipril 0.0 0.1 0.2 -0.0 0.1 0.4
Medication: Simvastatin 0.0 0.0 0.0 0.2 -0.1 0.2
Fluid intelligence score 0.7 1.5 2.8 1.7 0.1 1.2
Illnesses of siblings 0.6 0.8 1.2 -0.5 -1.1 -1.0
Neuroticism score 2.3 4.8 10.1 -3.2 1.5 -1.4
Weight 0.5 2.6 3.9 1.3 -1.4 2.0
Impedance of arm (right) 1.3 6.1 10.6 -1.3 3.2 2.5
Arm fat percentage (right) 0.8 3.2 5.3 -2.3 1.9 -0.9
Trunk fat-free mass 3.4 19.3 24.4 4.9 -4.9 3.1
Hip circumference 0.1 0.5 1.2 0.4 -1.1 0.3
Time employed in main current job 2.9 3.4 7.0 1.0 -2.6 -1.4
Alcohol intake versus 10 years previously 2.4 3.6 8.6 1.3 -0.7 2.9
Father’s age at death 0.4 0.5 1.5 -0.2 0.1 -1.2
Worrier / anxious feelings 0.1 0.2 0.4 -0.4 0.7 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.4 -0.6 0.1 0.5
Falls in the last year 3.9 5.3 7.7 2.7 -1.0 2.8
Hair/balding pattern: Pattern 3 1.0 1.6 4.3 -0.6 0.2 -2.1
Number of live births 1.7 2.5 4.6 -2.2 -0.9 -1.4
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 2.0 1.4 -0.1 0.4
Pulse rate 0.6 1.0 2.1 0.7 0.7 1.5
Happiness 2.1 2.6 6.9 0.9 0.3 2.6
Noisy workplace 0.2 0.2 0.3 0.3 -0.5 0.5
Qualifications: A levels/AS levels or equivalent 1.8 3.9 6.2 2.5 -1.4 1.9
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 0.5 -0.5 0.7 0.7
Mouth/teeth dental problems: Dentures 0.1 0.2 0.6 -0.7 0.1 0.2
Asthma 0.4 0.7 1.5 1.2 -0.9 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.3 -1.2 0.2 -0.2
Medication: Cholesterol lowering 0.3 0.5 1.3 -0.5 0.2 -1.1
Depression (self-reported) 0.1 0.1 0.3 -0.6 0.3 0.1
Medication: Lansoprazole 0.4 0.5 0.9 -0.6 1.0 0.2
Prospective memory result 0.6 0.8 2.1 -1.4 0.2 -0.4
Lung cancer (father) 0.5 0.6 0.9 -0.9 0.9 -0.2
Illnesses of mother 0.5 0.6 1.4 0.7 -1.2 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.8 0.9 -0.3 0.2
Pulse wave Arterial Stiffness index 0.3 0.3 0.5 0.4 -0.7 0.5
Impedance of arm (left) 1.3 5.9 11.2 -1.6 3.3 2.1
Arm fat mass (right) 0.1 0.3 0.6 -0.8 0.4 0.3
Trunk predicted mass 3.5 19.8 24.9 5.0 -4.9 3.2
Standing height 5.0 49.8 73.6 7.1 -5.0 8.6
Length of working week for main job 0.3 0.3 0.4 -0.6 0.3 0.6
Exposure to tobacco smoke at home 0.4 0.4 0.7 -0.8 0.7 0.3
Breastfed as a baby 3.0 3.8 4.9 -1.5 2.2 -2.0
Tense / ‘highly strung’ 0.5 0.8 1.7 -1.3 0.4 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.3 0.4 0.1 0.5
Hair/balding pattern: Pattern 4 10.0 24.3 47.5 2.0 4.6 6.9
Birth weight of first child 2.8 5.1 12.1 1.7 -3.5 -0.6
Peak expiratory flow (PEF) 0.3 0.7 1.9 0.5 0.3 -1.4
Pulse wave reflection index 0.4 0.4 1.0 0.4 -1.0 -0.5
Ever highly irritable/argumentative for 2 days 2.1 2.5 6.0 0.2 1.2 2.5
Loud music exposure frequency 0.5 0.5 1.3 -0.6 1.1 -0.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 0.8 0.8 -0.9 -0.0
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 1.5 1.0 -1.2 1.2
Blood clot in the leg (DVT) 2.7 3.5 5.0 -1.9 2.2 -1.4
Medication: Paracetamol 1.2 2.0 5.8 0.2 0.2 2.4
Headache pain in last month 0.9 1.5 2.5 -1.6 1.3 0.4
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.9 -1.0 -0.1 0.4
Glaucoma (self-reported) 1.2 1.4 3.3 -0.2 1.8 0.9
Gout (self-reported) 1.8 2.5 3.5 -1.9 1.4 -1.4
Hypothyroidism/myxoedema (self-reported) 6.3 12.2 27.0 -3.1 -0.3 -5.2
Medication: Amlodipine 1.0 1.4 2.2 0.1 1.5 -1.4
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.2 -0.4 -0.1 -1.5
Birth weight 5.7 12.3 20.4 3.1 -4.5 2.6
Chronic bronchitis/emphysema (mother) 4.1 4.8 9.3 -3.0 0.8 -2.1
High blood pressure (siblings) 0.4 0.5 1.3 1.2 0.5 0.2
Forced vital capacity (FVC), Best measure 1.5 5.4 8.5 2.9 -0.4 2.7
Body fat percentage 0.6 2.4 3.5 -1.9 1.7 0.9
Leg fat percentage (right) 0.4 1.6 2.7 -1.6 1.1 1.0
Arm fat-free mass (right) 2.3 11.9 16.7 3.6 -4.1 2.4
Exposure to tobacco smoke outside home 0.5 0.7 1.4 0.3 -0.8 1.2
Comparative body size at age 10 0.7 1.9 5.7 -2.4 0.1 -0.1
Number of full brothers 0.2 0.3 0.5 -0.7 0.5 0.0
Worry too long after embarrassment 0.2 0.3 0.8 0.1 -0.9 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.5 1.9 1.4 -0.8 1.4
Wheeze or whistling in the chest in last year 0.5 0.9 2.1 -1.4 0.7 0.2
Number of children fathered 1.2 1.4 3.0 1.7 -1.1 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.5 -0.4 1.2 -0.0
Age at first live birth 0.8 1.4 4.0 2.0 -0.1 -0.5
Pulse wave peak to peak time 0.1 0.1 0.2 0.1 0.4 0.3
Health satisfaction 0.6 0.7 1.6 0.2 0.8 1.3
Shortness of breath walking on level ground 0.9 1.1 2.5 -0.8 1.6 0.5
Qualifications: College or University degree 3.0 9.4 16.9 4.1 -1.7 2.9
Eye problems/disorders: None of the above 1.9 2.2 4.6 1.3 -2.1 0.7
Mouth/teeth dental problems: Loose teeth 0.8 1.0 1.5 1.0 -1.2 0.6
Emphysema/chronic bronchitis 0.4 0.5 1.0 -0.1 0.6 1.0
Medication for pain relief, constipation, heartburn 0.9 1.5 2.6 1.2 -0.6 -1.6
Neck or shoulder pain in last month 1.0 1.4 1.7 -1.3 -1.2 -1.0
Medication: Blood pressure 0.9 1.5 4.3 2.1 -0.3 0.5
Angina (self-reported) 0.1 0.2 0.4 0.3 -0.6 -0.2
Migraine (self-reported) 1.4 1.8 3.2 -1.2 1.8 -0.9
Medication: Ibuprofen 1.7 2.0 4.4 -2.1 0.7 -1.1
Medication: Allopurinol 0.1 0.1 0.2 -0.4 0.2 -0.4
Medication: Omeprazole 1.3 1.5 4.0 -0.6 0.4 2.0
Medication: Seretide 50 evohaler 1.6 1.9 4.5 1.0 -0.5 2.1
Mean time to correctly identify matches 0.4 0.7 1.2 1.1 -0.1 1.0
Heart disease (mother) 0.9 1.1 2.3 -1.0 1.5 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.5 0.9 -0.5 -0.7 -1.0
Whole body fat mass 0.2 0.9 2.2 -0.6 0.3 1.5
Leg fat mass (right) 0.2 0.8 2.0 -0.6 0.3 1.4
Arm predicted mass (right) 2.1 10.9 14.4 3.6 -3.8 2.4
Pulse rate, automated reading 1.1 3.4 5.9 1.1 2.4 1.8
Alcohol intake frequency. 1.2 2.8 5.4 -2.3 0.7 -1.5
Comparative height size at age 10 3.5 19.5 43.2 3.4 -1.9 6.6
Number of full sisters 0.4 0.5 0.9 -0.1 0.7 0.9
Suffer from ‘nerves’ 3.2 5.0 7.9 -2.5 0.8 -2.8
Overall health rating 0.4 0.9 1.6 -0.3 1.3 1.0
Chest pain or discomfort 0.1 0.1 0.2 -0.5 0.2 -0.4
Had major operations 0.4 0.4 0.7 -0.6 0.9 0.4
Age at last live birth 0.3 0.4 1.0 0.3 1.0 0.1
Family relationship satisfaction 4.0 4.9 10.0 1.9 -1.0 3.2
Leg pain on walking 0.9 1.1 3.2 -0.1 0.2 1.8
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.2 0.1 -0.0 1.1
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.4 -0.1 -0.7 -0.5
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 0.8 0.8 -0.5 -0.9
Medication: Aspirin 0.8 1.0 2.0 -1.0 1.4 0.4
Supplements: Vitamin C 0.9 1.0 1.5 -1.2 0.8 -0.9
Knee pain experienced in last month 0.5 0.8 1.4 -1.2 -0.9 -0.3
Hypertension (Self-reported) 0.4 1.1 3.1 0.4 1.8 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.5 0.1 0.4 1.2
Illnesses of father: Heart disease 0.3 0.4 0.7 0.8 -0.2 0.5
Illnesses of siblings: Diabetes 1.7 2.1 4.0 -2.0 1.0 -1.1
Smoking status: Previous 1.5 2.2 3.1 1.4 -1.8 -1.3
Forced expiratory volume in 1-second (FEV1), predicted 1.4 2.9 3.5 1.6 -1.9 1.6
Whole body fat-free mass 2.3 12.9 17.6 4.0 -4.2 2.3
Leg fat-free mass (right) 0.8 4.4 7.7 2.3 -2.8 0.7
Arm fat percentage (left) 1.0 4.1 6.9 -2.6 2.1 -0.9
Average weekly red wine intake 0.6 0.8 1.8 -0.2 -1.3 0.8
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.4 0.3 0.4 0.7
Mood swings 1.8 3.2 7.3 -2.7 0.9 -1.2
Loneliness, isolation 1.5 2.1 5.7 -2.4 0.8 -0.2
Long-standing illness, disability or infirmity 1.1 1.6 2.5 1.5 -0.4 1.6
Ever had bowel cancer screening 0.1 0.2 0.2 0.4 0.4 0.5
Diabetes diagnosed by doctor 0.6 1.0 1.9 -0.8 1.4 0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.4 0.4 0.2 1.2
Friendships satisfaction 2.2 2.7 6.8 1.2 0.0 2.6
Qualifications: nursing, teaching 0.3 0.4 1.3 -0.2 -0.1 -1.1
Commuting to job workplace: Walk 0.1 0.2 0.4 0.7 -0.2 0.1
Eye problems/disorders: Cataract 1.8 2.1 4.1 -1.2 2.0 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.1 0.7 -1.5 -0.7
Medication for cholesterol 2.0 3.0 8.3 0.3 -2.9 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.7 4.6 0.2 -0.6 2.1
Back pain experienced in last month 0.2 0.3 0.7 -0.9 -0.2 -0.0
Mineral and other dietary supplements 0.3 0.4 0.6 -0.1 0.8 -0.8
Breast cancer (self-reported) 2.9 3.5 4.8 -2.0 2.2 -1.3
Asthma (self-reported) 0.3 0.6 1.5 1.2 -0.6 0.2
Osteoporosis (self-reported) 2.4 2.9 6.1 -1.4 2.5 0.9
Osteoarthritis (self-reported) 0.2 0.2 0.4 -0.0 -0.4 -0.6
Medication: Aspirin 1.1 1.5 2.5 -1.4 1.6 0.2
Medication: Gliclazide 0.6 0.7 0.8 -0.9 0.7 -0.8
Illnesses of father: None of the above (group 1) 0.4 0.5 1.2 -1.1 0.4 -0.2
Smoking status: Current 1.3 2.0 3.2 -1.5 0.7 1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 2.0 0.4 -0.4 -1.4
Whole body water mass 2.2 12.7 18.2 3.9 -4.3 2.1
Leg predicted mass (right) 0.9 4.6 7.9 2.3 -2.8 0.7
Arm fat mass (left) 0.1 0.2 0.4 -0.6 0.3 0.4
Number of self-reported non-cancer illnesses 0.3 0.6 1.1 0.4 1.0 0.7
Average weekly champagne plus white wine intake 2.9 4.0 6.3 -2.5 1.7 -1.6
Miserableness 0.9 1.6 2.9 -1.7 1.3 -0.4
Guilty feelings 0.8 1.2 3.3 -1.8 0.5 0.2
Wears glasses or contact lenses 0.0 0.0 0.1 0.3 0.1 0.1
Ever taken oral contraceptive pill 2.1 2.3 5.9 0.9 -2.4 -0.5
Hearing aid user 0.1 0.1 0.2 -0.1 -0.4 0.2
Mother’s age at death 0.4 0.6 1.1 1.1 -0.5 0.5
Financial situation satisfaction 0.9 1.1 3.1 -0.3 -0.2 1.8
Tinnitus: Yes, now most or all of the time 1.4 1.7 3.5 -1.0 0.7 -1.9
Commuting to job workplace: Public transport 1.1 1.3 2.4 1.5 -0.0 1.2
Eye problems/disorders: Glaucoma 0.8 1.0 2.6 -0.2 1.6 0.5
Medication: Blood pressure 2.0 3.8 10.7 -0.9 3.3 -0.2
Pain type(s) experienced in last month: Hip pain 0.9 1.2 1.7 -1.3 -0.2 -1.3
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.1 -0.6 -1.1 -0.3
High cholesterol (Self-reported) 0.4 0.6 1.2 -0.8 1.1 -0.3
Medication: Bendroflumethiazide 1.6 2.4 3.4 1.0 1.9 1.7
Medication: Paracetamol 0.6 0.9 2.5 -0.2 -0.2 1.6
Medication: Lisinopril 0.5 0.7 1.4 0.0 0.8 1.2
Medication: Atorvastatin 0.4 0.5 0.8 -0.1 0.7 0.9
Illnesses of father: High blood pressure 2.2 2.8 4.1 -0.9 2.0 -1.8
Alcohol drinker status: Never 0.5 0.6 1.5 -1.2 0.4 -0.2
Ever smoked 0.1 0.1 0.3 -0.0 -0.4 -0.5
Basal metabolic rate 1.9 10.5 13.5 3.5 -3.7 2.4
Leg fat percentage (left) 0.5 1.9 3.4 -1.8 1.3 0.7
Arm fat-free mass (left) 2.6 13.1 16.1 4.0 -4.0 2.7
Number of operations (self-reported) 0.8 1.2 2.5 -1.0 0.3 -1.6
Average weekly beer plus cider intake 1.0 1.4 1.7 1.0 -1.3 1.3
Irritability 2.4 4.0 7.7 -2.8 1.4 -1.6
Risk taking 1.5 2.2 4.4 1.3 -0.8 2.1
Ever had prostate specific antigen (PSA) test 3.9 4.5 9.7 2.0 -3.1 0.0
Fractured/broken bones in last 5 years 1.4 1.9 3.1 0.3 1.5 1.8
Age started oral contraceptive pill 0.2 0.3 0.7 -0.2 0.8 -0.4
Diastolic blood pressure, automated reading 0.6 1.9 5.3 -0.2 2.3 -0.5
Ever depressed for a whole week 0.9 1.1 2.3 -1.0 1.5 0.3
Unable to work because of sickness or disability 0.1 0.2 0.4 -0.2 0.4 0.6
Commuting to job workplace: Cycle 0.4 0.4 1.3 0.1 -1.1 0.1
Myopia 1.2 1.7 4.4 -0.3 0.7 -2.1
Vascular/heart problems diagnosed by doctor 0.5 1.5 4.1 -0.3 -2.0 -0.4
Cholesterol lowering medication 0.5 0.8 1.4 -0.5 1.2 0.8
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 3.6 -0.8 0.7 1.9
Pain experienced in last month 0.8 1.3 3.5 1.9 -0.5 -0.5
Supplements: Calcium 0.3 0.3 0.6 -0.3 0.6 -0.7
Basal cell carcinoma (self-reported) 0.3 0.3 0.6 0.8 -0.6 0.2
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.0 -0.5 -1.0 -0.3
Deep venous thrombosis (DVT) (self-reported) 3.5 4.6 6.5 -2.2 2.5 -1.5
Heart disease (siblings) 0.6 0.7 1.5 0.8 -0.2 1.2
Alcohol drinker status: Previous 0.1 0.1 0.3 -0.6 -0.0 -0.3
Pack years of smoking 0.8 1.2 3.4 0.3 -0.3 1.9
Impedance of whole body 1.5 7.6 15.8 -0.5 2.6 4.0
Leg fat mass (left) 0.2 0.6 1.5 -0.6 0.2 1.2
Arm predicted mass (left) 2.7 13.7 16.6 4.1 -4.1 2.8