Best TWAS P=2.6e-13 · Best GWAS P=8.84e-42 conditioned to 8.57e-23
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EYA4 | 0.15 | 0.07 | blup | 567 | 0.12 | 2.0e-14 | -5.5 | -6.8 | 1.1e-11 | -0.49 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | SLC18B1 | 0.42 | 0.22 | lasso | 4 | 0.28 | 9.4e-10 | 5.2 | -5.5 | 3.3e-08 | -0.05 | 0.95 | 0.01 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | SLC18B1 | 0.21 | 0.18 | lasso | 3 | 0.18 | 3.1e-13 | 5.2 | -5.2 | 2.1e-07 | -0.09 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Esophagus Muscularis | RPS12 | 0.12 | 0.03 | enet | 20 | 0.01 | 4.1e-02 | -6.7 | 5.9 | 4.2e-09 | 0.03 | 0.19 | 0.12 | FALSE |
| 5 | GTEx | Whole Blood | SLC18B1 | 0.11 | 0.05 | enet | 7 | 0.04 | 9.3e-05 | 5.3 | -5.5 | 3.1e-08 | -0.04 | 0.96 | 0.00 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | LINC00326 | 0.44 | 0.48 | lasso | 4 | 0.48 | 1.5e-69 | -5.4 | 5.6 | 2.4e-08 | -0.04 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EYA4 | 0.03 | 0.03 | enet | 8 | 0.02 | 5.5e-05 | -5.6 | 7.3 | 2.6e-13 | 0.22 | 0.97 | 0.00 | TRUE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C6orf192 | 0.05 | 0.02 | enet | 11 | 0.02 | 2.5e-03 | 4.7 | -6.7 | 2.7e-11 | -0.04 | 0.00 | 0.73 | TRUE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EYA4 | 0.03 | 0.03 | lasso | 2 | 0.02 | 1.1e-03 | -5.0 | -5.2 | 1.7e-07 | -0.32 | 0.27 | 0.02 | TRUE |
| 10 | The Cancer Genome Atlas | Lung Adenocarcinoma | C6orf192 | 0.09 | 0.05 | blup | 79 | 0.04 | 4.4e-05 | 4.7 | -5.2 | 2.5e-07 | -0.11 | 0.01 | 0.99 | FALSE |