[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (right) : ← →

chr14:103,161,201-104,892,153

Best TWAS P=8.01e-17 · Best GWAS P=4.35e-17 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TRMT61A	0.06	0.03	lasso	3	0.04	6.6e-06	3.9	-6.5	1.1e-10	0.79	0.03	0.96	FALSE
2	GTEx	Adipose Subcutaneous	MARK3	0.12	0.05	lasso	3	0.06	2.5e-05	-8.4	-8.0	1.8e-15	0.93	0.01	0.98	FALSE
3	GTEx	Artery Aorta	TRMT61A	0.14	0.07	lasso	5	0.12	6.4e-07	-8.3	-8.1	6.0e-16	0.84	0.02	0.98	FALSE
4	GTEx	Artery Tibial	TRMT61A	0.07	0.07	lasso	3	0.06	2.4e-05	-8.3	-7.9	3.9e-15	0.96	0.02	0.98	FALSE
5	GTEx	Brain Frontal Cortex BA9	APOPT1	0.17	0.07	lasso	3	0.08	4.6e-03	4.2	-5.2	1.7e-07	0.68	0.11	0.44	FALSE
6	GTEx	Breast Mammary Tissue	MARK3	0.12	0.11	lasso	2	0.08	3.9e-05	-8.3	-8.3	8.9e-17	0.98	0.01	0.98	FALSE
7	GTEx	Breast Mammary Tissue (Male)	MARK3	0.08	0.00	enet	9	-0.01	7.2e-01	-8.3	-7.4	1.4e-13	0.85	0.02	0.46	FALSE
8	GTEx	Lung	MARK3	0.06	0.02	lasso	3	0.01	6.6e-02	-8.3	-7.9	3.7e-15	0.96	0.02	0.97	FALSE
9	GTEx	Lung	CKB	0.07	0.01	lasso	2	0.01	3.4e-02	-5.0	-7.2	6.4e-13	0.91	0.02	0.94	FALSE
10	GTEx	Muscle Skeletal	ZFYVE21	0.10	0.05	lasso	2	0.03	3.3e-04	-5.1	5.4	5.4e-08	-0.69	0.58	0.11	FALSE
11	GTEx	Muscle Skeletal	APOPT1	0.14	0.21	enet	10	0.22	6.7e-21	-4.9	5.6	2.2e-08	-0.77	1.00	0.00	FALSE
12	GTEx	Pituitary	MARK3	0.21	0.27	enet	8	0.25	4.9e-07	-8.3	-8.1	4.9e-16	0.98	0.02	0.97	FALSE
13	GTEx	Prostate	MARK3	0.18	0.22	enet	11	0.20	8.0e-06	-8.3	-8.1	7.4e-16	0.97	0.02	0.97	FALSE
14	GTEx	Skin Not Sun Exposed Suprapubic	MARK3	0.16	0.10	lasso	3	0.10	6.7e-06	-8.3	-8.0	1.2e-15	0.95	0.01	0.99	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	CKB	0.28	0.26	lasso	4	0.25	6.4e-14	-5.2	-5.3	1.1e-07	0.69	0.98	0.02	FALSE
16	GTEx	Skin Sun Exposed Lower leg	MARK3	0.10	0.09	enet	13	0.08	7.5e-07	-8.4	-7.9	2.6e-15	0.93	0.01	0.99	FALSE
17	GTEx	Skin Sun Exposed Lower leg	CKB	0.43	0.32	enet	16	0.34	5.9e-29	-5.2	-5.8	6.0e-09	0.74	1.00	0.00	FALSE
18	GTEx	Stomach	MARK3	0.10	0.09	lasso	2	0.04	4.5e-03	-8.3	-8.3	8.0e-17	0.98	0.02	0.96	TRUE
19	GTEx	Stomach	TRMT61A	0.12	0.11	lasso	5	0.08	1.2e-04	-8.3	-8.3	8.7e-17	0.98	0.02	0.97	FALSE
20	GTEx	Testis	APOPT1	0.13	0.07	enet	21	0.12	8.4e-06	3.3	5.2	2.7e-07	-0.70	0.20	0.70	FALSE
21	GTEx	Thyroid	MARK3	0.38	0.48	lasso	4	0.48	2.8e-41	-8.3	-8.3	9.2e-17	0.98	0.01	0.99	FALSE
22	NTR	Blood	BAG5	0.02	0.00	lasso	5	0.01	6.3e-03	-4.9	5.3	1.1e-07	-0.76	0.20	0.57	FALSE
23	YFS	Blood	KLC1	0.01	0.01	blup	389	0.01	1.0e-03	-5.2	5.9	4.0e-09	-0.77	0.13	0.65	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	C14orf153	0.05	0.02	lasso	4	0.02	8.0e-05	-4.9	-5.3	1.2e-07	0.77	0.09	0.88	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	CKB	0.06	0.03	lasso	3	0.03	2.5e-06	-5.2	-5.2	2.0e-07	0.70	0.37	0.55	FALSE
26	The Cancer Genome Atlas	Colon Adenocarcinoma	C14orf153	0.07	0.05	lasso	4	0.04	1.5e-03	-5.5	-5.3	1.0e-07	0.73	0.04	0.46	FALSE
27	The Cancer Genome Atlas	Glioblastoma Multiforme	C14orf153	0.14	0.01	blup	40	0.03	3.5e-02	-4.9	-6.2	5.2e-10	0.84	0.01	0.52	FALSE
28	The Cancer Genome Atlas	Glioblastoma Multiforme	MARK3	0.12	0.05	blup	64	0.07	3.3e-03	-8.3	-8.3	9.7e-17	0.93	0.01	0.63	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BAG5	0.06	0.02	blup	30	0.03	1.4e-04	2.7	-5.8	8.6e-09	0.70	0.03	0.93	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MARK3	0.07	0.03	blup	64	0.06	5.5e-07	-5.2	-6.2	5.0e-10	0.79	0.03	0.96	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	C14orf153	0.04	0.01	blup	38	0.03	6.2e-04	2.8	-5.4	7.7e-08	0.69	0.09	0.14	FALSE
32	The Cancer Genome Atlas	Lung Adenocarcinoma	C14orf153	0.06	0.02	blup	38	0.04	2.4e-05	-4.9	-5.8	8.4e-09	0.75	0.04	0.84	FALSE
33	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C14orf153	0.05	0.05	blup	40	0.04	8.6e-06	-5.5	-5.9	3.4e-09	0.79	0.35	0.57	FALSE
34	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CKB	0.03	0.00	blup	34	0.02	1.4e-03	2.5	-6.1	1.0e-09	0.78	0.02	0.65	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TRMT61A	0.02	0.00	blup	34	0.01	6.2e-02	3.1	-6.7	3.0e-11	0.81	0.01	0.73	FALSE
36	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	BAG5	0.08	0.09	lasso	2	0.08	3.7e-04	-8.3	-8.3	1.1e-16	0.98	0.00	0.97	FALSE
37	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C14orf153	0.11	0.11	lasso	3	0.10	1.1e-04	-5.5	-5.5	4.7e-08	0.74	0.07	0.70	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	C14orf153	0.09	0.08	blup	38	0.09	6.2e-10	-5.5	-6.6	3.9e-11	0.83	0.06	0.94	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	MARK3	0.07	0.06	enet	7	0.08	1.0e-08	-5.2	-6.9	4.9e-12	0.86	0.04	0.96	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRMT61A	0.03	0.01	blup	32	0.01	1.4e-02	-8.3	-7.4	1.7e-13	0.85	0.00	0.68	FALSE
41	The Cancer Genome Atlas	Rectum Adenocarcinoma	BAG5	0.17	-0.01	blup	32	0.02	1.3e-01	3.9	-6.0	1.6e-09	0.78	0.01	0.47	FALSE
42	The Cancer Genome Atlas	Stomach Adenocarcinoma	C14orf153	0.20	0.05	lasso	2	0.04	8.8e-04	4.2	-5.2	1.5e-07	0.65	0.02	0.70	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	MARK3	0.10	0.03	blup	61	0.03	4.0e-04	-5.2	-5.2	1.8e-07	0.68	0.01	0.60	FALSE