TWAS
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Traits
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Pulse rate
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chr6:120,704,438-122,457,698
Best TWAS P=2.17e-17 · Best GWAS P=5.4e-38 conditioned to 1.71e-12
120.8M
121M
121.2M
121.4M
121.6M
121.8M
122M
122.2M
122.4M
0
10
20
30
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
METSIM
Adipose
GJA1
0.06
0.01
bslmm
348
0.03
4.0e-05
7.8
8.5
2.2e-17
0.42
0.38
0.10
TRUE
1
GTEx
Cells Transformed fibroblasts
GJA1
0.13
0.07
enet
14
0.13
2.9e-10
3.7
8.2
3.5e-16
0.51
0.86
0.10
TRUE
4
METSIM
Adipose
TBC1D32
0.05
0.01
bslmm
423
0.02
4.7e-04
3.7
5.5
4.0e-08
0.18
0.51
0.06
TRUE
5
The Cancer Genome Atlas
Ovarian Serous Cystadenocarcinoma
C6orf170
0.05
0.01
blup
116
0.04
1.7e-03
3.9
-5.2
1.7e-07
-0.04
0.18
0.20
TRUE
2
GTEx
Esophagus Mucosa
GJA1
0.25
0.05
lasso
10
0.11
8.5e-08
1.5
6.0
1.5e-09
0.40
0.84
0.02
FALSE