Best TWAS P=2.17e-17 · Best GWAS P=5.4e-38 conditioned to 1.71e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | GJA1 | 0.13 | 0.07 | enet | 14 | 0.13 | 2.9e-10 | 3.7 | 8.2 | 3.5e-16 | 0.51 | 0.86 | 0.10 | TRUE |
| 2 | GTEx | Esophagus Mucosa | GJA1 | 0.25 | 0.05 | lasso | 10 | 0.11 | 8.5e-08 | 1.5 | 6.0 | 1.5e-09 | 0.40 | 0.84 | 0.02 | FALSE |
| 3 | METSIM | Adipose | GJA1 | 0.06 | 0.01 | bslmm | 348 | 0.03 | 4.0e-05 | 7.8 | 8.5 | 2.2e-17 | 0.42 | 0.38 | 0.10 | TRUE |
| 4 | METSIM | Adipose | TBC1D32 | 0.05 | 0.01 | bslmm | 423 | 0.02 | 4.7e-04 | 3.7 | 5.5 | 4.0e-08 | 0.18 | 0.51 | 0.06 | TRUE |
| 5 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C6orf170 | 0.05 | 0.01 | blup | 116 | 0.04 | 1.7e-03 | 3.9 | -5.2 | 1.7e-07 | -0.04 | 0.18 | 0.20 | TRUE |