Best TWAS P=2.41e-17 · Best GWAS P=3.52e-19 conditioned to 1.08e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Pituitary | BBS4 | 0.27 | 0.02 | enet | 21 | 0.05 | 2.1e-02 | -4.4 | -5.6 | 2.0e-08 | 0.07 | 0.08 | 0.16 | TRUE |
| 2 | GTEx | Spleen | NEO1 | 0.39 | 0.00 | lasso | 9 | 0.01 | 2.0e-01 | 7.8 | -6.0 | 1.8e-09 | 0.22 | 0.06 | 0.06 | FALSE |
| 3 | NTR | Blood | NEO1 | 0.04 | 0.01 | lasso | 4 | 0.02 | 4.1e-06 | 5.7 | -6.4 | 1.7e-10 | 0.33 | 0.92 | 0.02 | FALSE |
| 4 | The Cancer Genome Atlas | Thyroid Carcinoma | HCN4 | 0.03 | 0.00 | blup | 52 | 0.02 | 2.0e-03 | 1.5 | 8.5 | 2.4e-17 | -0.52 | 0.01 | 0.45 | TRUE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | NEO1 | 0.03 | 0.02 | lasso | 3 | 0.02 | 6.2e-03 | 7.6 | -7.0 | 3.0e-12 | 0.29 | 0.05 | 0.52 | TRUE |