[Hub]/) : Traits : Ever highly irritable/argumentative for 2 days :

chr3:49,016,056-51,043,528

Best TWAS P=9.74e-09 · Best GWAS P=6.41e-08 conditioned to 0.0489

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Visceral Omentum	RBM6	0.20	0.28	enet	30	0.30	6.4e-16	-4.9	-5.3	1.1e-07	-0.71	0.09	0.90	FALSE
2	GTEx	Artery Aorta	RBM6	0.32	0.36	lasso	6	0.41	3.3e-24	-4.9	-5.1	2.9e-07	-0.74	0.08	0.92	FALSE
3	GTEx	Artery Aorta	APEH	0.05	0.03	enet	8	0.01	9.1e-02	-5.4	-5.3	1.4e-07	-0.76	0.06	0.86	FALSE
4	GTEx	Artery Tibial	RBM6	0.24	0.31	enet	24	0.30	5.8e-24	-4.9	-5.1	2.8e-07	-0.70	0.09	0.91	FALSE
5	GTEx	Artery Tibial	UBA7	0.04	0.03	lasso	4	0.02	7.8e-03	-5.3	-5.3	1.4e-07	-0.79	0.07	0.67	FALSE
6	GTEx	Brain Caudate basal ganglia	RBM6	0.20	0.14	enet	16	0.11	5.5e-04	-3.7	-5.7	9.7e-09	-0.70	0.07	0.90	TRUE
7	GTEx	Brain Cerebellum	RBM6	0.25	0.41	enet	32	0.33	2.1e-10	-5.0	-5.1	2.8e-07	-0.71	0.09	0.91	FALSE
8	GTEx	Brain Cerebellum	RNF123	0.36	0.31	enet	43	0.36	2.4e-11	3.7	5.1	2.6e-07	0.58	0.69	0.30	FALSE
9	GTEx	Brain Cerebellum	MST1R	0.19	0.24	enet	22	0.20	1.8e-06	-5.4	5.4	8.6e-08	0.71	0.06	0.94	FALSE
10	GTEx	Breast Mammary Tissue	RBM6	0.25	0.35	enet	26	0.38	7.4e-21	-5.4	-5.2	1.7e-07	-0.70	0.06	0.94	FALSE
11	GTEx	Breast Mammary Tissue (Female)	RBM6	0.23	0.27	enet	16	0.26	2.7e-08	4.8	-5.2	2.1e-07	-0.66	0.07	0.93	FALSE
12	GTEx	Colon Sigmoid	RBM6	0.25	0.19	enet	7	0.13	2.3e-05	-4.9	-5.1	2.6e-07	-0.66	0.09	0.91	FALSE
13	GTEx	Esophagus Mucosa	RBM6	0.18	0.21	enet	18	0.23	3.0e-15	5.0	-5.4	7.6e-08	-0.67	0.10	0.90	FALSE
14	GTEx	Esophagus Muscularis	MST1R	0.05	0.00	lasso	5	0.05	3.6e-04	-5.0	5.3	1.4e-07	0.59	0.09	0.74	FALSE
15	GTEx	Heart Atrial Appendage	RBM6	0.34	0.36	lasso	6	0.35	1.2e-16	-4.9	-5.2	2.6e-07	-0.70	0.10	0.89	FALSE
16	GTEx	Heart Left Ventricle	RBM6	0.09	0.08	enet	10	0.11	3.0e-06	-5.4	-5.3	9.2e-08	-0.74	0.05	0.95	FALSE
17	GTEx	Lung	RBM6	0.17	0.20	lasso	6	0.24	4.6e-18	-5.4	-5.3	1.2e-07	-0.70	0.08	0.92	FALSE
18	GTEx	Muscle Skeletal	RBM6	0.11	0.15	enet	13	0.15	3.1e-14	-5.4	-5.4	7.2e-08	-0.75	0.05	0.95	FALSE
19	GTEx	Nerve Tibial	RBM6	0.41	0.42	enet	19	0.41	8.8e-31	-4.9	-5.2	1.9e-07	-0.68	0.11	0.89	FALSE
20	GTEx	Nerve Tibial	HYAL1	0.08	0.06	enet	14	0.05	3.6e-04	4.8	5.5	3.1e-08	0.82	0.11	0.69	FALSE
21	GTEx	Pancreas	RBM6	0.23	0.20	lasso	4	0.22	1.3e-09	-4.9	-5.2	2.3e-07	-0.69	0.06	0.94	FALSE
22	GTEx	Pituitary	RBM6	0.27	0.21	enet	22	0.19	1.5e-05	-5.2	-5.3	9.8e-08	-0.85	0.09	0.89	FALSE
23	GTEx	Prostate	RBM6	0.14	0.12	enet	15	0.05	1.8e-02	-5.0	-5.3	1.3e-07	-0.67	0.07	0.80	FALSE
24	GTEx	Skin Sun Exposed Lower leg	RBM6	0.23	0.27	lasso	8	0.29	7.6e-24	-5.0	-5.2	1.7e-07	-0.68	0.07	0.93	FALSE
25	GTEx	Small Intestine Terminal Ileum	MST1R	0.20	0.05	lasso	5	0.10	3.6e-03	4.8	5.4	6.4e-08	0.75	0.08	0.65	FALSE
26	GTEx	Spleen	RBM6	0.36	0.39	lasso	8	0.40	2.0e-11	-5.3	-5.4	8.7e-08	-0.75	0.04	0.96	FALSE
27	GTEx	Thyroid	RBM6	0.25	0.35	lasso	15	0.36	1.9e-28	-4.9	-5.3	9.2e-08	-0.73	0.11	0.89	FALSE
28	NTR	Blood	RBM6	0.06	0.14	enet	36	0.13	7.9e-40	-5.0	-5.2	2.0e-07	-0.73	0.10	0.90	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	SEMA3F	0.07	0.11	bslmm	275	0.10	4.9e-13	5.2	-5.3	1.1e-07	-0.82	0.05	0.95	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	MST1R	0.02	0.00	blup	278	0.01	4.5e-02	4.8	5.1	2.9e-07	0.62	0.10	0.86	FALSE
31	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RBM6	0.09	0.13	blup	79	0.12	1.6e-06	-5.2	-5.4	7.1e-08	-0.72	0.05	0.95	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RBM6	0.04	0.05	blup	79	0.05	2.0e-06	4.8	-5.1	2.7e-07	-0.74	0.10	0.90	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MST1R	0.03	0.04	blup	32	0.05	4.0e-06	4.8	5.1	3.0e-07	0.69	0.02	0.98	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEMA3F	0.02	0.04	lasso	3	0.03	2.3e-04	-5.3	-5.5	4.8e-08	-0.89	0.01	0.94	FALSE
35	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RBM6	0.09	0.07	blup	79	0.08	1.3e-04	-5.4	-5.3	1.2e-07	-0.74	0.04	0.95	FALSE
36	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RBM6	0.06	0.05	enet	6	0.07	7.3e-04	3.4	-5.1	2.7e-07	-0.61	0.03	0.68	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	MST1R	0.03	0.01	blup	32	0.03	3.1e-04	5.0	5.1	2.6e-07	0.68	0.02	0.93	FALSE