Hub : Genes

SEMA3F

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1240 0.0580 9.1e-04 0.031 NA 0.059 NA 0.036 7.5e-03 NA 3.6e-04 NA 4.5e-03
2 GTEx Nerve Tibial 0.1187 0.0496 9.6e-04 -0.002 NA 0.003 NA 0.014 5.4e-01 NA 1.8e-01 NA 3.3e-02
3 ROSMAP Brain Pre-frontal Cortex 0.0745 0.0273 1.3e-11 0.113 0.101 0.102 0.102 0.102 2.7e-14 5.8e-13 5.3e-13 4.9e-13 5.0e-13
4 TCGA Brain Lower Grade Glioma 0.0239 0.0135 1.5e-03 0.035 0.026 0.028 NA 0.030 6.8e-05 5.8e-04 3.2e-04 NA 2.3e-04
5 TCGA Prostate Adenocarcinoma 0.0810 0.0409 1.7e-07 0.047 0.065 0.069 NA 0.064 1.0e-05 2.2e-07 1.1e-07 NA 2.6e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.5 2.4 5.1 0.6 -0.2 -2.2 -2.2 1.3
Bipolar Disorder or Schizophrenia 0.6 1.5 4.2 -1.0 2.0 -0.4 -1.4 0.0
Depressed Affect (Nagel 2018) 7.7 16.2 24.6 3.7 -3.0 -5.0 -4.7 3.4
Depression (Nagel 2018) 2.1 3.1 8.8 0.5 -1.1 -3.0 -2.3 0.3
Intelligence (Savage-Jansen 2018) 23.8 73.0 86.9 -8.8 8.0 7.9 8.7 -9.3
Neuroticism (Nagel 2018) 2.7 6.2 18.4 0.9 -1.0 -4.3 -3.3 0.5
Schizophrenia (2018) 1.2 2.5 6.8 -1.7 2.6 1.3 -0.0 -1.0
Schizophrenia vs Biploar Disorder 8.3 10.9 19.9 -3.3 2.1 4.5 3.2 -3.1
Worry (Nagel 2018) 1.8 3.9 13.4 -0.5 -0.1 -3.7 -2.3 -0.7
Alzheimer’s Disease (in mother) 1.1 1.3 3.1 0.6 -0.3 -1.2 -1.8 1.1
Alzheimer’s Disease (in father) 0.4 0.4 1.1 0.5 -0.4 -0.4 -0.7 1.1
Alzheimer’s Disease (including proxy) 2.2 3.2 6.7 1.2 -1.0 -1.1 -2.6 2.4
Crohns Disease (2017) 10.1 22.2 32.3 -5.7 5.1 5.2 3.5 -3.7
Irritable Bowel Disease (IBD) 16.9 40.3 56.6 -7.5 6.9 6.4 4.8 -5.7
Ulcerative Colitis (UC) 16.2 30.5 40.4 -6.4 6.0 5.3 4.4 -5.3
Major Depression (MDD) 0.6 0.8 3.6 0.4 0.0 -1.9 0.0 0.0
Reaction Time 1.8 3.5 5.0 -2.2 1.1 1.9 2.0 -1.9
Verbal and Numeric Reasoning (VNR) 15.3 36.6 43.0 -5.9 5.3 6.2 6.6 -6.2
Breast Cancer 1.6 3.9 6.3 -1.1 2.1 2.5 2.3 -1.5
Ovarian Cancer 0.1 0.1 0.4 0.0 -0.6 0.2 0.4 0.0
Prostate Cancer 5.5 7.8 14.4 3.7 -1.9 -3.8 -1.8 1.8
Age at First Birth 19.8 28.8 40.4 -4.5 4.1 5.6 6.4 -5.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0
Body Mass Index (BMI) (2010) 5.5 7.6 11.0 2.8 -1.9 -2.3 -3.1 3.3
Coronary Artery Disease (CAD) 5.5 6.6 9.3 2.4 -2.7 -2.4 -2.3 3.0
Crohns Disease (2012) 11.9 19.2 22.7 -4.6 4.8 4.2 4.1 -4.1
Mean Putamen Volume 0.4 0.4 1.0 0.2 0.5 -1.0 0.5 -0.7
Fasting Glucose 0.6 0.7 1.4 1.2 -1.1 -0.1 -0.2 0.7
HbA1C 2.2 2.5 3.6 -1.4 1.7 1.1 1.9 -1.6
HDL Cholesterol 5.5 9.2 14.8 -2.1 2.4 3.6 3.9 -2.8
LDL Cholesterol 0.3 0.5 1.6 -0.2 -0.5 1.3 -0.0 0.8
Lupus 2.5 3.8 7.4 2.2 -0.1 -1.6 -2.1 2.7
Neuroticism (2016) 2.3 3.3 8.0 0.6 -2.1 -2.8 -1.8 0.2
Primary Biliary Cirrhosis 1.5 2.1 5.0 -0.4 0.4 1.4 2.2 -1.7
Rheumatoid Arthritis 0.2 0.3 0.9 0.1 0.9 0.1 0.5 -0.7
Schizophrenia (2014) 1.1 2.5 5.6 -2.1 2.4 1.2 -0.1 -1.1
Triglycerides 0.0 0.1 0.2 -0.1 0.4 0.3 0.2 0.0
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.6 -0.0 0.0 -0.4 -0.2 0.8
Ulcerative Colitis 14.7 21.3 28.4 -5.3 4.7 4.7 3.9 -4.4
Blood Eosinophil Count 3.3 25.4 35.1 3.3 -3.7 -5.9 -5.8 5.8
Blood Platelet Count 0.1 1.2 4.2 0.1 0.4 1.2 -0.2 2.1
Blood Red Count 0.3 3.3 12.7 1.2 0.3 -3.6 -0.9 -1.1
Blood White Count 4.6 33.9 38.8 5.5 -6.2 -6.2 -5.6 5.5
Heel T-Score 3.5 27.9 55.5 2.8 -7.5 -4.0 -6.3 4.5
BMI 18.0 104.4 141.6 10.5 -8.2 -9.0 -11.0 11.9
Height 0.1 1.3 2.8 -0.9 1.7 -0.2 0.9 -1.3
Waist Hip Ratio (WHR) 0.7 3.1 5.1 -2.1 1.1 -2.3 -0.9 -2.0
Systolic Blood Pressure 0.3 1.6 5.0 0.3 2.2 -1.4 -0.9 -0.3
Smoking Status 4.1 9.7 19.2 3.5 -2.2 -2.0 -2.9 4.4
Allergy or Eczema 0.1 0.2 0.4 0.2 0.0 0.1 -0.6 0.7
Cardiovascular Disease 0.3 1.1 1.8 0.4 1.4 -1.4 -1.3 0.3
Hypothyroidism (self reported) 0.3 0.8 1.6 0.2 1.1 -1.3 -1.0 -0.0
Respiratory disease 6.3 13.9 21.3 3.1 -1.8 -4.5 -4.6 4.0
Type 2 Diabetes (T2D) (2018) 4.9 9.1 16.3 2.2 -1.3 -3.8 -4.0 2.9
Lung FEV1/FVC ratio 0.1 0.3 1.0 -0.5 1.0 -0.6 0.1 -0.3
Lung FVC 1.9 9.9 15.9 -2.7 4.0 3.9 2.4 -2.4
Neuroticism 3.2 7.8 21.5 1.0 -1.4 -4.6 -3.7 0.7
Chronotype (morning person) 7.9 18.3 40.6 -5.1 1.7 6.4 4.2 -2.0
Hair Pigment 0.1 1.8 3.4 1.6 -0.0 -1.0 -1.3 1.8
Tanning 0.4 4.4 7.3 2.0 -2.6 -1.3 -1.5 2.7
Hand grip strength (left) 1.3 3.4 7.2 2.0 -2.7 -0.5 -0.6 2.3
Number of treatments/medications taken 11.7 21.0 33.7 4.5 -2.5 -5.8 -5.1 4.2
Average weekly spirits intake 4.9 6.0 13.9 2.2 -3.7 -2.2 -1.6 2.1
Sensitivity / hurt feelings 0.8 1.4 2.8 -1.0 1.2 -1.7 -1.0 -0.9
Frequency of depressed mood in last 2 weeks 3.6 5.0 11.9 1.0 -1.4 -3.5 -3.0 0.9
Hearing difficulty/problems: Yes 0.1 0.1 0.2 -0.4 -0.3 -0.1 -0.2 -0.3
Relative age of first facial hair 2.9 6.0 12.2 1.4 -0.8 -3.2 -3.5 2.2
Other serious medical condition/disability diagnosed by doctor 1.9 2.5 7.3 -1.0 2.7 0.3 0.7 -1.9
Ever used hormone-replacement therapy (HRT) 3.4 4.3 7.3 1.9 -1.5 -1.8 -2.3 2.7
Ever had hysterectomy (womb removed) 10.0 11.3 15.4 3.9 -2.7 -2.9 -3.7 3.4
Systolic blood pressure, automated reading 0.2 0.6 1.1 0.6 1.0 -0.6 -0.8 0.7
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 2.4 0.2 -0.7 -1.5 -0.8 -0.7
Angina 0.5 0.6 1.2 0.5 -1.0 -0.8 -1.1 0.4
Medication for hormone replacement therapy 3.7 4.2 6.5 2.3 -1.6 -1.5 -2.0 2.5
Vitamin and mineral supplements 0.9 1.2 3.4 0.7 -1.8 -0.7 -1.0 0.9
Supplements: Zinc 1.3 1.5 2.7 -1.6 1.4 0.9 0.8 -0.9
Medication: Co-codamol 9.7 11.3 13.0 3.3 -3.1 -3.6 -3.3 3.5
Medication: Metformin 1.2 1.6 4.4 0.7 -0.1 -1.5 -2.1 1.0
Diabetes (father) 2.1 2.6 6.9 1.4 -0.3 -2.6 -1.9 0.7
Diabetes (mother) 0.4 0.5 1.4 -0.1 -0.6 -1.2 -0.9 0.0
Severe depression (siblings) 1.2 1.4 2.4 -1.5 1.6 -1.0 -0.5 -1.0
Pack years adult smoking proportion 0.6 0.9 1.8 1.4 -0.5 -0.5 -0.9 1.3
Impedance of leg (right) 5.2 25.4 55.5 -6.1 2.4 2.5 4.7 -7.5
Leg fat-free mass (left) 9.3 49.1 72.8 8.0 -4.4 -6.0 -7.3 8.5
Trunk fat percentage 11.8 47.3 49.8 7.0 -6.8 -6.6 -7.1 6.9
Hand grip strength (right) 3.0 8.1 12.0 3.4 -3.2 -1.9 -1.8 3.5
Townsend deprivation index at recruitment 0.3 0.4 1.0 0.1 0.5 -0.2 -1.0 0.7
Current tobacco smoking 4.2 6.9 8.9 2.7 -2.8 -2.2 -2.4 3.0
Average weekly fortified wine intake 0.3 0.4 0.7 0.7 -0.6 -0.8 -0.2 0.6
Maternal smoking around birth 4.6 6.7 12.5 2.1 -1.1 -1.8 -3.5 3.5
Fed-up feelings 10.2 18.6 22.6 4.2 -4.5 -4.8 -4.4 3.7
Frequency of unenthusiasm / disinterest in last 2 weeks 5.2 6.9 12.9 1.4 -2.2 -3.6 -3.5 1.6
Relative age voice broke 0.4 0.6 1.0 0.4 -0.6 -0.8 -1.0 1.0
Taking other prescription medications 17.3 26.7 41.3 4.2 -3.5 -6.2 -6.4 5.0
Age when periods started (menarche) 8.2 19.6 28.3 5.3 -3.0 -4.5 -4.4 4.7
Bilateral oophorectomy (both ovaries removed) 6.3 7.3 13.1 2.1 -1.9 -2.8 -3.6 2.7
Heel bone mineral density (BMD) T-score, automated (left) 2.7 6.1 10.0 2.1 -1.6 -3.2 -3.0 2.0
Tinnitus: Yes, but not now, but have in the past 5.3 5.7 7.2 1.8 -2.4 -2.7 -2.5 2.3
Qualifications: CSEs or equivalent 7.6 10.0 14.8 3.1 -2.2 -2.9 -3.6 3.8
Serious illness, injury or assault to yourself 0.2 0.2 0.6 -0.3 0.8 0.5 -0.4 0.4
High blood pressure 0.5 1.4 6.2 0.2 2.5 -0.5 -0.8 0.1
Hayfever, allergic rhinitis or eczema 0.2 0.5 0.9 0.2 -0.9 -0.4 -1.0 0.6
Multivitamins +/- minerals 0.5 0.6 1.9 -0.1 1.4 0.3 1.0 -0.3
Stomach or abdominal pain in last month 1.3 1.6 4.8 0.7 -0.7 -2.2 -1.4 -0.2
Supplements: Glucosamine 0.4 0.5 1.0 -0.4 0.8 0.8 1.0 -0.4
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.8 0.7 -0.2 -0.5 0.4 -0.9
Medication: Atenolol 3.1 3.9 6.1 2.0 -1.3 -2.5 -2.0 1.8
Medication: Levothyroxine sodium 0.5 0.8 1.5 0.6 1.0 -1.2 -0.9 -0.5
Sitting height 0.3 2.2 5.5 2.0 -0.8 0.2 -0.8 2.3
Chronic bronchitis/emphysema (father) 4.2 4.9 6.4 1.6 -2.5 -2.5 -2.4 1.9
High blood pressure (mother) 2.0 2.8 9.2 -1.8 3.0 0.4 0.6 -1.0
Body mass index (BMI) 20.1 85.8 108.2 9.7 -7.0 -8.6 -10.1 10.4
Impedance of leg (left) 6.1 29.9 61.8 -6.6 2.9 2.9 5.2 -7.9
Leg predicted mass (left) 9.2 48.7 72.2 8.0 -4.3 -6.0 -7.3 8.5
Trunk fat mass 14.1 60.5 67.6 8.1 -6.7 -7.6 -8.2 8.2
Waist circumference 12.0 43.7 59.5 6.5 -4.5 -7.1 -7.7 6.8
Number of incorrect matches in round 0.5 0.9 3.3 -0.4 -0.1 1.8 0.6 0.7
Past tobacco smoking 1.0 1.8 6.2 -1.0 -0.2 -0.3 1.4 -2.5
Alcohol usually taken with meals 2.8 4.5 5.6 -1.6 2.2 2.1 2.4 -2.3
Nervous feelings 1.2 2.3 5.7 -1.7 0.6 -2.4 -0.6 -1.4
Frequency of tenseness / restlessness in last 2 weeks 6.4 10.0 16.5 2.2 -2.5 -4.1 -4.0 2.6
Hearing difficulty/problems with background noise 0.3 0.5 1.1 -0.8 -0.1 1.1 0.6 -0.7
Hair/balding pattern: Pattern 2 2.9 3.7 7.3 1.0 -0.5 -2.6 -2.7 1.7
Had menopause 0.4 0.5 1.8 0.0 1.3 0.6 0.7 -0.3
Had other major operations 4.6 5.6 12.4 0.9 -0.1 -2.6 -3.5 2.8
Forced vital capacity (FVC) 1.6 6.3 11.6 -2.5 3.4 2.2 1.9 -2.3
Heel bone mineral density (BMD) T-score, automated (right) 2.6 6.0 10.8 2.2 -1.9 -3.3 -2.8 1.6
Ever unenthusiastic/disinterested for a whole week 7.1 8.7 19.2 1.9 -1.7 -4.4 -3.9 1.7
Qualifications: None of the above 12.6 26.9 31.7 5.6 -4.6 -5.5 -4.7 5.3
Financial difficulties in last 2 years 1.9 2.6 4.4 1.5 -1.6 -2.1 -1.6 1.1
Mouth/teeth dental problems 2.4 3.7 6.4 -1.3 0.5 2.1 2.4 -2.5
Heart attack 2.0 2.6 4.5 1.4 -0.2 -1.6 -2.1 2.0
Allergy 2.8 6.4 11.6 -2.0 1.0 2.8 3.4 -2.6
Pain all over the body in last month 6.5 6.9 8.2 2.5 -2.8 -2.8 -2.9 2.0
Diabetes (self-reported) 3.9 6.0 12.6 1.9 -0.7 -3.5 -3.2 1.8
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.4 -0.6 -0.3 -0.3 -0.1 -0.1
Medication: Ramipril 1.0 1.3 1.9 0.9 1.2 -1.2 -1.4 0.9
Medication: Simvastatin 0.2 0.3 0.8 -0.0 -0.5 0.1 -0.6 0.9
Fluid intelligence score 14.8 30.8 34.6 -5.3 5.1 5.9 5.9 -5.5
Illnesses of siblings 1.8 2.5 6.5 -0.7 -0.7 2.6 2.2 0.0
Neuroticism score 3.8 7.9 21.9 0.8 -1.5 -4.7 -3.7 0.9
Weight 14.6 71.7 90.1 9.0 -5.9 -8.2 -9.2 9.5
Impedance of arm (right) 9.2 42.7 62.1 -7.2 2.2 6.2 7.5 -7.9
Arm fat percentage (right) 14.3 56.5 62.1 7.9 -6.9 -7.2 -7.8 7.8
Trunk fat-free mass 5.2 29.6 42.8 6.2 -1.6 -5.3 -6.0 6.5
Hip circumference 9.4 40.6 58.8 7.7 -4.5 -5.6 -6.4 7.2
Time employed in main current job 0.4 0.4 1.0 -0.5 0.1 1.0 0.9 -0.3
Alcohol intake versus 10 years previously 16.9 25.3 30.4 4.6 -4.5 -5.4 -5.5 5.1
Father’s age at death 4.1 5.4 7.2 -2.2 2.2 2.4 2.7 -2.1
Worrier / anxious feelings 1.5 2.8 10.2 0.1 -0.6 -3.2 -1.8 -0.4
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.5 7.0 1.3 -0.2 -2.6 -1.8 0.7
Falls in the last year 0.6 0.7 1.4 0.2 -0.1 -1.1 -1.2 1.0
Hair/balding pattern: Pattern 3 2.1 3.1 8.8 -0.3 -0.6 1.8 3.0 -1.7
Number of live births 7.1 10.1 16.1 2.7 -2.6 -2.8 -3.6 4.0
Forced expiratory volume in 1-second (FEV1) 1.8 6.2 13.4 -2.5 3.7 1.5 1.6 -2.4
Pulse rate 0.5 0.8 2.1 0.4 -1.4 -1.0 -0.6 -0.8
Happiness 2.0 2.4 4.6 -2.1 2.1 0.3 0.2 -1.7
Noisy workplace 5.6 7.0 10.9 1.8 -2.2 -3.3 -3.1 2.5
Qualifications: A levels/AS levels or equivalent 25.4 56.3 63.2 -7.3 7.2 7.5 7.5 -8.0
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 -0.1 0.4 0.6 0.1 0.6
Mouth/teeth dental problems: Dentures 10.0 16.8 23.0 4.1 -3.0 -4.2 -4.1 4.8
Asthma 6.3 12.4 19.3 3.2 -1.5 -4.1 -4.4 3.7
Medication: Ibuprofen (e.g. Nurofen) 2.1 2.7 3.9 2.0 0.1 -1.7 -1.7 1.9
Medication: Cholesterol lowering 1.5 2.3 3.9 2.0 -0.1 -0.9 -1.7 1.9
Depression (self-reported) 1.1 1.3 2.6 -0.1 0.1 -1.6 -1.6 1.1
Medication: Lansoprazole 4.6 5.2 9.4 1.7 -1.2 -2.3 -3.1 2.6
Prospective memory result 7.8 9.5 10.6 3.3 -3.1 -2.8 -3.2 3.1
Lung cancer (father) 4.0 4.7 5.9 2.0 -2.4 -1.8 -2.4 2.1
Illnesses of mother 0.6 0.7 1.8 0.9 -1.3 0.7 0.8 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 2.4 7.6 13.5 -3.0 3.7 2.3 2.0 -2.5
Pulse wave Arterial Stiffness index 0.6 0.7 1.3 1.1 -0.4 -1.1 -0.8 0.6
Impedance of arm (left) 8.7 40.3 54.9 -7.1 1.9 6.3 7.2 -7.4
Arm fat mass (right) 18.1 74.5 86.3 9.3 -6.9 -8.3 -9.1 9.3
Trunk predicted mass 4.9 27.8 40.2 6.0 -1.5 -5.2 -5.8 6.3
Standing height 0.1 0.8 3.1 -0.4 1.8 -0.2 0.6 -0.7
Length of working week for main job 0.5 0.6 1.4 -0.8 1.2 0.5 0.4 -0.6
Exposure to tobacco smoke at home 5.5 6.2 7.9 2.8 -1.7 -2.8 -2.4 2.6
Breastfed as a baby 2.1 2.6 8.1 -0.2 0.4 2.8 2.2 0.2
Tense / ‘highly strung’ 2.0 3.3 9.9 0.1 -0.2 -3.1 -2.6 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 4.1 6.3 11.5 1.6 -1.4 -3.3 -3.4 2.1
Hair/balding pattern: Pattern 4 0.4 1.0 3.2 0.6 0.1 0.8 -1.0 1.8
Birth weight of first child 0.8 1.5 4.4 -1.2 1.1 2.1 0.6 0.2
Peak expiratory flow (PEF) 2.0 4.7 10.3 -2.4 3.2 2.1 1.2 -1.2
Pulse wave reflection index 0.9 1.1 2.4 1.0 0.2 -0.8 -1.2 1.6
Ever highly irritable/argumentative for 2 days 15.1 18.1 29.8 3.2 -2.6 -5.3 -5.5 3.9
Loud music exposure frequency 2.1 2.3 4.7 -1.8 1.8 -0.3 0.7 -2.2
Qualifications: O levels/GCSEs or equivalent 3.9 6.2 8.3 -2.5 2.9 1.9 2.1 -2.9
Mouth/teeth dental problems: Bleeding gums 2.1 2.7 4.8 -2.2 1.9 1.2 1.2 -1.5
Blood clot in the leg (DVT) 2.3 3.0 5.9 2.4 -0.7 -2.1 -1.8 0.9
Medication: Paracetamol 4.1 6.8 10.7 3.3 -1.6 -3.0 -2.1 2.7
Headache pain in last month 0.5 0.9 2.0 0.3 -0.7 -1.4 -1.1 0.8
Medication for cholesterol, blood pressure or diabetes 3.4 5.7 8.0 -2.6 1.2 2.2 2.8 -2.8
Glaucoma (self-reported) 2.5 2.9 5.0 -2.2 1.6 1.3 0.7 -2.2
Gout (self-reported) 0.7 1.0 1.7 0.4 -1.2 -1.3 -1.1 0.4
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.9 0.3 1.4 -1.0 -0.9 -0.2
Medication: Amlodipine 0.1 0.1 0.2 -0.2 0.4 0.3 -0.4 0.5
Medication: Ventolin 100micrograms inhaler 7.5 9.6 12.9 3.0 -1.7 -3.5 -3.6 3.2
Birth weight 0.4 0.8 2.2 -0.1 0.0 1.5 1.2 0.6
Chronic bronchitis/emphysema (mother) 8.5 9.9 15.2 2.4 -1.4 -3.4 -3.9 3.8
High blood pressure (siblings) 1.4 2.0 6.2 0.6 0.0 -2.5 -1.9 0.3
Forced vital capacity (FVC), Best measure 2.2 8.0 11.9 -3.0 3.4 2.7 2.4 -2.5
Body fat percentage 14.3 56.4 62.1 7.7 -7.1 -7.4 -7.9 7.5
Leg fat percentage (right) 16.9 61.4 75.3 8.0 -6.6 -8.3 -8.7 7.5
Arm fat-free mass (right) 9.1 46.9 65.3 7.5 -3.2 -6.6 -7.7 8.1
Exposure to tobacco smoke outside home 7.6 10.2 14.7 2.9 -2.2 -3.2 -3.6 3.8
Comparative body size at age 10 2.0 5.6 17.4 2.4 -1.6 -0.1 -1.4 4.2
Number of full brothers 4.6 5.8 8.5 2.8 -1.1 -2.9 -2.4 2.3
Worry too long after embarrassment 4.2 7.0 14.7 -3.8 1.4 1.3 1.8 -3.7
Seen a psychiatrist for nerves, anxiety, tension or depression 2.3 3.0 6.6 0.3 -0.9 -2.6 -2.5 1.1
Wheeze or whistling in the chest in last year 15.8 28.2 38.4 4.5 -4.5 -5.6 -6.2 5.5
Number of children fathered 8.1 9.2 13.3 3.4 -2.4 -2.8 -2.8 3.6
Reason for reducing amount of alcohol drunk: Health precaution 0.8 1.0 1.8 -1.2 1.0 1.4 0.6 -0.7
Age at first live birth 16.6 29.4 47.6 -4.5 3.1 6.0 6.9 -5.7
Pulse wave peak to peak time 0.7 0.8 1.4 -1.1 0.5 1.2 0.9 -0.6
Health satisfaction 4.4 5.7 11.7 1.4 -1.0 -3.4 -3.4 1.5
Shortness of breath walking on level ground 7.8 9.3 12.8 3.4 -1.8 -3.3 -3.6 2.8
Qualifications: College or University degree 33.3 104.9 127.7 -11.3 8.9 9.9 9.6 -11.3
Eye problems/disorders: None of the above 1.3 1.5 3.2 1.0 -1.1 1.4 0.6 1.8
Mouth/teeth dental problems: Loose teeth 1.3 1.5 2.5 1.2 -0.9 -1.0 -1.6 1.5
Emphysema/chronic bronchitis 0.2 0.2 0.8 0.1 0.9 0.1 0.2 0.0
Medication for pain relief, constipation, heartburn 1.8 3.0 5.4 -1.8 -0.4 2.3 1.8 -1.7
Neck or shoulder pain in last month 4.3 6.1 8.2 2.3 -1.6 -2.8 -2.9 2.5
Medication: Blood pressure 2.4 4.2 6.5 2.3 -0.2 -2.1 -2.5 2.2
Angina (self-reported) 0.2 0.2 0.5 0.3 -0.6 -0.4 -0.7 0.2
Migraine (self-reported) 0.4 0.5 0.9 0.2 0.5 -1.0 -0.9 0.5
Medication: Ibuprofen 1.6 1.9 3.1 1.5 0.2 -1.3 -1.6 1.7
Medication: Allopurinol 0.4 0.5 0.9 -0.4 -0.8 -0.9 -0.9 -0.1
Medication: Omeprazole 7.9 9.4 14.7 3.1 -1.5 -3.8 -3.5 3.0
Medication: Seretide 50 evohaler 6.0 7.0 12.1 2.6 -2.4 -3.5 -2.5 2.0
Mean time to correctly identify matches 2.9 5.6 8.1 -2.2 1.8 2.6 2.8 -2.1
Heart disease (mother) 0.7 0.8 1.5 -0.9 0.8 1.2 1.0 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.7 3.2 4.8 -2.2 2.1 1.6 1.2 -1.6
Whole body fat mass 17.6 73.3 82.8 9.1 -7.1 -8.4 -9.0 9.0
Leg fat mass (right) 19.7 76.5 90.8 9.2 -6.8 -8.8 -9.5 9.1
Arm predicted mass (right) 9.6 48.9 65.1 7.6 -3.4 -7.0 -7.8 8.1
Pulse rate, automated reading 2.8 9.2 15.3 2.2 -3.9 -3.6 -3.4 1.1
Alcohol intake frequency. 7.6 17.7 27.9 3.2 -2.5 -5.1 -5.3 4.2
Comparative height size at age 10 0.8 4.2 7.7 -1.6 1.5 1.9 2.8 -2.2
Number of full sisters 2.6 3.2 8.2 0.5 0.6 -2.5 -2.9 1.0
Suffer from ‘nerves’ 0.5 0.8 2.1 -0.8 0.4 -1.4 -0.4 -1.0
Overall health rating 16.4 35.2 53.3 5.5 -4.5 -7.3 -6.7 5.1
Chest pain or discomfort 6.2 8.9 12.8 3.4 -1.9 -3.6 -3.0 2.8
Had major operations 1.8 2.1 6.2 1.3 -1.0 -2.5 -1.1 0.7
Age at last live birth 19.9 28.9 50.8 -4.4 3.2 5.9 7.1 -5.5
Family relationship satisfaction 0.7 0.8 2.2 -0.4 -0.3 -1.3 -1.5 0.2
Leg pain on walking 14.0 17.6 24.9 4.4 -2.2 -4.4 -5.0 4.5
Qualifications: NVQ or HND or HNC or equivalent 9.2 11.1 18.7 2.4 -2.9 -3.5 -4.3 3.2
Commuting to job workplace: Car/motor vehicle 3.1 3.6 4.9 2.1 -0.9 -2.2 -1.8 2.1
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.6 -0.8 -0.6 0.6 -0.3 -0.4
Medication: Aspirin 0.8 1.0 3.2 -0.6 1.8 0.6 0.7 -0.7
Supplements: Vitamin C 0.4 0.4 1.1 -0.2 -0.2 0.9 1.1 -0.5
Knee pain experienced in last month 9.5 14.7 19.7 4.1 -1.4 -4.1 -4.4 4.3
Hypertension (Self-reported) 0.7 2.0 9.1 -0.2 3.0 -0.4 -0.7 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.4 4.0 5.8 1.8 -1.2 -2.2 -2.4 2.1
Illnesses of father: Heart disease 0.5 0.7 2.3 -1.5 0.7 0.3 -0.1 -0.6
Illnesses of siblings: Diabetes 6.2 7.6 14.2 2.0 -1.8 -3.8 -3.6 1.8
Smoking status: Previous 1.0 1.5 5.5 0.8 0.4 0.7 -1.0 2.3
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 2.2 -0.2 1.5 -0.9 -1.2 0.3
Whole body fat-free mass 6.9 39.7 58.5 7.1 -2.8 -5.9 -6.9 7.7
Leg fat-free mass (right) 7.6 40.6 63.6 7.3 -3.6 -5.3 -6.7 8.0
Arm fat percentage (left) 14.9 59.6 66.4 8.0 -7.3 -7.1 -8.1 8.1
Average weekly red wine intake 4.9 7.2 12.9 -2.2 2.0 3.6 3.2 -2.1
Handedness (chirality/laterality): Left-handed 3.0 3.6 7.5 -2.7 0.9 1.5 1.8 -2.0
Mood swings 7.4 13.5 24.3 2.5 -2.7 -4.6 -4.9 2.8
Loneliness, isolation 4.6 6.3 10.8 3.0 -0.7 -3.3 -2.8 2.0
Long-standing illness, disability or infirmity 3.2 5.0 9.9 1.4 0.5 -3.0 -3.2 1.9
Ever had bowel cancer screening 7.8 9.1 12.7 -2.4 2.8 3.3 3.6 -2.9
Diabetes diagnosed by doctor 3.2 5.3 9.9 1.7 -0.5 -3.1 -3.1 1.8
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 1.3 -1.1 -1.0 0.2 -1.1 1.0
Friendships satisfaction 2.9 3.6 7.5 -2.5 1.2 1.1 1.4 -2.7
Qualifications: nursing, teaching 7.5 11.7 15.2 -3.9 3.1 3.8 3.0 -3.2
Commuting to job workplace: Walk 4.7 5.1 7.1 -2.1 1.6 2.4 2.7 -2.4
Eye problems/disorders: Cataract 1.1 1.2 2.6 -0.7 1.5 -0.2 1.0 -1.6
Mouth/teeth dental problems: Mouth ulcers 1.0 1.5 3.2 1.0 0.5 -1.5 -1.8 1.0
Medication for cholesterol 0.7 1.1 2.2 -0.5 0.3 1.4 1.5 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 3.1 1.0 0.4 -1.8 -0.7 -0.1
Back pain experienced in last month 2.0 2.9 4.5 1.0 -1.5 -1.7 -2.1 2.0
Mineral and other dietary supplements 0.5 0.7 1.5 0.0 -1.2 -1.0 -0.9 0.3
Breast cancer (self-reported) 3.2 3.8 6.5 1.8 -2.1 -0.9 -2.0 2.5
Asthma (self-reported) 6.8 13.5 20.5 3.3 -1.7 -4.2 -4.5 4.0
Osteoporosis (self-reported) 0.8 1.0 2.2 0.9 -1.5 0.1 -0.7 1.2
Osteoarthritis (self-reported) 7.5 9.7 13.9 3.4 -1.6 -3.7 -3.4 2.9
Medication: Aspirin 1.0 1.3 2.9 -1.1 1.7 0.7 0.9 -0.9
Medication: Gliclazide 1.4 1.6 3.4 0.2 -1.0 -1.8 -1.8 0.5
Illnesses of father: None of the above (group 1) 0.1 0.2 0.6 0.5 -0.7 -0.1 0.0 0.2
Smoking status: Current 3.9 6.1 7.3 2.5 -2.7 -2.2 -2.3 2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.9 6.2 10.4 -3.2 1.8 2.7 2.0 -2.3
Whole body water mass 7.2 40.9 59.5 7.2 -2.8 -6.0 -7.0 7.7
Leg predicted mass (right) 7.5 40.1 63.1 7.3 -3.6 -5.3 -6.6 7.9
Arm fat mass (left) 18.4 75.7 90.1 9.2 -7.0 -8.2 -9.2 9.5
Number of self-reported non-cancer illnesses 4.0 7.0 15.6 1.5 -0.7 -3.9 -3.6 1.9
Average weekly champagne plus white wine intake 3.0 4.1 6.3 -2.5 1.4 2.4 1.9 -1.6
Miserableness 12.1 20.9 33.6 3.4 -3.9 -5.8 -5.5 3.8
Guilty feelings 2.6 4.0 6.5 1.4 -1.7 -2.5 -2.1 2.0
Wears glasses or contact lenses 1.3 1.4 2.9 1.7 -1.5 -0.8 -0.6 1.1
Ever taken oral contraceptive pill 1.5 1.6 4.7 0.2 -0.8 -0.3 -1.7 2.2
Hearing aid user 0.2 0.2 0.5 0.4 0.0 -0.7 -0.5 0.4
Mother’s age at death 3.5 4.4 7.2 -2.7 1.3 1.5 2.0 -2.6
Financial situation satisfaction 4.6 5.8 11.1 1.8 -1.3 -2.7 -3.3 2.3
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.4 0.5 1.2 -0.2 0.2 -0.4
Commuting to job workplace: Public transport 2.3 2.7 5.8 -0.6 -0.2 1.8 2.4 -2.0
Eye problems/disorders: Glaucoma 1.2 1.4 3.1 -1.8 1.1 -0.2 -0.3 -1.6
Medication: Blood pressure 0.9 1.7 6.3 -1.1 2.5 -0.4 -0.4 -0.9
Pain type(s) experienced in last month: Hip pain 4.5 5.6 9.2 2.5 -0.7 -2.1 -2.7 3.0
Supplements: Fish oil (including cod liver oil) 1.3 1.7 3.7 -0.2 1.9 1.7 1.2 -0.3
High cholesterol (Self-reported) 0.3 0.6 1.8 -0.8 0.2 1.3 0.7 0.3
Medication: Bendroflumethiazide 0.2 0.3 0.8 0.5 0.2 -0.7 -0.9 0.4
Medication: Paracetamol 5.2 8.0 12.0 3.5 -2.1 -3.2 -2.3 2.9
Medication: Lisinopril 0.3 0.4 0.8 0.4 0.8 -0.9 -0.6 0.2
Medication: Atorvastatin 0.3 0.4 1.1 0.4 1.0 -0.6 -0.5 0.1
Illnesses of father: High blood pressure 1.3 1.6 5.2 -0.8 2.3 -0.2 -0.4 -1.3
Alcohol drinker status: Never 0.3 0.4 1.1 -1.1 0.8 0.1 -0.0 -0.4
Ever smoked 0.7 1.2 3.8 0.7 -0.3 0.0 -1.2 2.0
Basal metabolic rate 9.2 50.9 69.6 7.9 -3.7 -6.9 -7.8 8.3
Leg fat percentage (left) 16.4 59.2 71.7 7.8 -6.4 -8.1 -8.5 7.5
Arm fat-free mass (left) 9.7 49.4 63.5 7.8 -3.1 -7.2 -7.9 8.0
Number of operations (self-reported) 8.9 13.3 18.8 3.1 -2.0 -4.2 -4.3 4.0
Average weekly beer plus cider intake 18.0 26.0 32.9 4.9 -4.5 -5.2 -5.7 5.1
Irritability 0.7 1.2 2.0 -0.7 1.4 -1.3 -0.9 -0.9
Risk taking 1.6 2.3 5.1 1.0 -0.7 -1.5 -2.3 1.7
Ever had prostate specific antigen (PSA) test 0.1 0.2 0.5 0.7 0.3 -0.3 0.3 -0.2
Fractured/broken bones in last 5 years 0.4 0.5 1.1 -0.0 1.0 0.5 0.9 -0.6
Age started oral contraceptive pill 5.3 6.6 12.2 -1.5 1.5 2.6 3.5 -3.1
Diastolic blood pressure, automated reading 3.1 9.7 16.2 2.7 -1.1 -3.9 -4.0 3.0
Ever depressed for a whole week 3.2 4.0 9.1 1.2 -0.6 -3.0 -2.8 1.2
Unable to work because of sickness or disability 1.1 1.4 2.7 0.7 -1.2 -1.6 -1.5 0.2
Commuting to job workplace: Cycle 2.2 2.7 6.5 -2.6 0.2 2.0 1.4 -1.0
Myopia 0.1 0.1 0.2 0.3 -0.4 0.3 -0.1 0.4
Vascular/heart problems diagnosed by doctor 0.5 1.4 4.5 -0.3 -2.1 0.9 1.2 -0.3
Cholesterol lowering medication 0.6 0.8 1.6 -0.7 -0.9 -0.7 -1.3 0.9
Medication: Omeprazole (e.g. Zanprol) 5.7 6.9 10.4 2.7 -1.3 -3.2 -3.1 2.4
Pain experienced in last month 8.0 13.3 15.7 -3.5 3.0 3.8 4.0 -3.9
Supplements: Calcium 1.0 1.1 1.9 -0.6 0.9 1.4 1.2 -1.0
Basal cell carcinoma (self-reported) 3.8 4.5 8.2 -1.3 1.9 2.9 2.4 -1.8
Heart attack/myocardial infarction (self-reported) 1.5 1.9 3.5 1.1 -0.1 -1.3 -1.9 1.7
Deep venous thrombosis (DVT) (self-reported) 2.3 2.9 5.6 2.4 -0.6 -2.2 -1.8 0.8
Heart disease (siblings) 0.0 0.0 0.1 0.2 -0.1 -0.2 0.0 -0.3
Alcohol drinker status: Previous 1.4 1.6 3.0 1.1 -1.1 -0.3 -1.5 1.7
Pack years of smoking 0.2 0.3 0.7 0.8 0.4 -0.0 -0.3 0.6
Impedance of whole body 8.2 41.5 70.6 -7.5 2.4 5.2 6.9 -8.4
Leg fat mass (left) 19.7 77.0 91.8 9.2 -6.8 -8.8 -9.6 9.2
Arm predicted mass (left) 10.4 52.9 67.4 8.1 -3.3 -7.4 -8.1 8.2