Hub : Traits :

Ever highly irritable/argumentative for 2 days

37 significantly associated models · 7 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	49016056	51043528	7	1	9.7e-09	6.4e-08	0.049	87	RBM6

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Age at last live birth	36.2	1	1	2.2	1	RBM6
Age at First Birth	34.1	1	1	2.2	1	RBM6
Qualifications: College or University degree	29.6	1	1	2.2	1	RBM6
Age at first live birth	29.1	1	1	2.2	1	RBM6
Miserableness	28.0	1	1	2.2	1	RBM6
Body mass index (BMI)	27.9	1	1	2.2	1	RBM6
Taking other prescription medications	25.8	1	1	2.2	1	RBM6
Qualifications: A levels/AS levels or equivalent	25.7	1	1	2.2	1	RBM6
Leg fat mass (left)	25.4	1	1	2.2	1	RBM6
Leg fat mass (right)	25.3	1	1	2.2	1	RBM6
BMI	24.0	1	1	2.2	1	RBM6
Overall health rating	22.6	1	1	2.2	1	RBM6
Leg fat percentage (right)	22.3	1	1	2.2	1	RBM6
Leg fat percentage (left)	21.7	1	1	2.2	1	RBM6
Impedance of arm (left)	21.6	1	1	2.2	1	RBM6
Impedance of arm (right)	21.4	1	1	2.2	1	RBM6
Qualifications: None of the above	20.8	1	1	2.2	1	RBM6
Arm fat mass (right)	20.8	1	1	2.2	1	RBM6
Arm fat mass (left)	20.8	1	1	2.2	1	RBM6
Average weekly beer plus cider intake	20.8	1	1	2.2	1	RBM6
Ever unenthusiastic/disinterested for a whole week	19.7	1	0	0.0	1	RBM6
Ever depressed for a whole week	19.0	1	0	0.0	1	RBM6
Number of treatments/medications taken	18.9	1	1	2.2	1	RBM6
Fluid intelligence score	18.8	1	1	2.2	1	RBM6
Whole body fat mass	18.5	1	1	2.2	1	RBM6
Intelligence (Savage-Jansen 2018)	18.2	1	1	2.2	1	RBM6
Waist circumference	18.1	1	1	2.2	1	RBM6
Medication: Co-codamol	17.8	1	0	0.0	1	RBM6
Exposure to tobacco smoke at home	17.7	1	0	0.0	1	RBM6
Wheeze or whistling in the chest in last year	17.3	1	1	2.2	1	RBM6
Weight	17.2	1	1	2.2	1	RBM6
Mood swings	16.9	1	1	2.2	1	RBM6
Impedance of whole body	16.5	1	1	2.2	1	RBM6
Verbal and Numeric Reasoning (VNR)	16.4	1	1	2.2	1	RBM6
Arm fat percentage (right)	15.7	1	1	2.2	1	RBM6
Diabetes (self-reported)	15.4	1	0	0.0	1	RBM6
Arm fat percentage (left)	15.3	1	1	2.2	1	RBM6
Arm predicted mass (left)	14.8	1	1	2.2	1	RBM6
Neuroticism score	14.7	1	1	2.2	1	RBM6
Depressed Affect (Nagel 2018)	14.6	1	1	2.2	1	RBM6
Arm fat-free mass (left)	14.5	1	1	2.2	1	RBM6
Chronic bronchitis/emphysema (mother)	14.2	1	0	0.0	1	RBM6
Medication: Seretide 50 evohaler	14.0	1	0	0.0	1	RBM6
Trunk fat mass	13.8	1	1	2.2	1	RBM6
Alcohol intake versus 10 years previously	13.7	1	0	0.0	1	RBM6
Body fat percentage	13.6	1	1	2.2	1	RBM6
Arm predicted mass (right)	13.5	1	1	2.2	1	RBM6
Type 2 Diabetes (T2D) (2018)	13.2	1	0	0.0	1	RBM6
Number of operations (self-reported)	12.7	1	0	0.0	1	RBM6
Neuroticism	12.5	1	1	2.2	1	RBM6
Exposure to tobacco smoke outside home	12.5	1	0	0.0	1	RBM6
Number of full sisters	12.5	1	0	0.0	1	RBM6
Diabetes diagnosed by doctor	12.5	1	0	0.0	1	RBM6
Arm fat-free mass (right)	12.4	1	1	2.2	1	RBM6
Age started oral contraceptive pill	11.8	1	0	0.0	1	RBM6
Number of live births	11.7	1	0	0.0	1	RBM6
Fed-up feelings	11.6	1	0	0.0	1	RBM6
Basal metabolic rate	11.6	1	1	2.2	1	RBM6
Illnesses of siblings: Diabetes	11.3	1	0	0.0	1	RBM6
Chronic bronchitis/emphysema (father)	11.0	1	0	0.0	1	RBM6
Ever had bowel cancer screening	10.9	1	0	0.0	1	RBM6
Schizophrenia vs Biploar Disorder	10.8	1	0	0.0	1	RBM6
Medication: Ventolin 100micrograms inhaler	10.7	1	0	0.0	1	RBM6
Average weekly red wine intake	10.7	1	0	0.0	1	RBM6
Hip circumference	10.6	1	1	2.2	1	RBM6
Relative age of first facial hair	10.4	1	0	0.0	1	RBM6
Frequency of unenthusiasm / disinterest in last 2 weeks	10.4	1	0	0.0	1	RBM6
Frequency of tenseness / restlessness in last 2 weeks	10.4	1	0	0.0	1	RBM6
Mouth/teeth dental problems: Dentures	10.3	1	0	0.0	1	RBM6
Neuroticism (Nagel 2018)	10.1	1	0	0.0	1	RBM6
Guilty feelings	10.1	1	0	0.0	1	RBM6
Alcohol intake frequency.	10.0	1	0	0.0	1	RBM6
Ulcerative Colitis (UC)	9.8	1	0	0.0	1	RBM6
Bilateral oophorectomy (both ovaries removed)	9.8	1	0	0.0	1	RBM6
Qualifications: CSEs or equivalent	9.8	1	0	0.0	1	RBM6
Respiratory disease	9.7	1	0	0.0	1	RBM6
Qualifications: NVQ or HND or HNC or equivalent	9.7	1	0	0.0	1	RBM6
Whole body water mass	9.4	1	1	2.2	1	RBM6
Trunk fat percentage	9.3	1	1	2.2	1	RBM6
Pain experienced in last month	9.2	1	0	0.0	1	RBM6
Whole body fat-free mass	9.1	1	1	2.2	1	RBM6
Leg fat-free mass (left)	9.0	1	1	2.2	1	RBM6
Leg predicted mass (left)	9.0	1	1	2.2	1	RBM6
Leg pain on walking	9.0	1	0	0.0	1	RBM6
Seen doctor (GP) for nerves, anxiety, tension or depression	8.9	1	0	0.0	1	RBM6
Breastfed as a baby	8.8	1	0	0.0	1	RBM6
Financial situation satisfaction	8.5	1	0	0.0	1	RBM6
Health satisfaction	8.4	1	0	0.0	1	RBM6
Knee pain experienced in last month	8.3	1	0	0.0	1	RBM6
Asthma (self-reported)	8.2	1	0	0.0	1	RBM6
HDL Cholesterol	8.1	1	0	0.0	1	RBM6
Ulcerative Colitis	8.1	1	0	0.0	1	RBM6
Asthma	8.1	1	0	0.0	1	RBM6
Body Mass Index (BMI) (2010)	8.0	1	0	0.0	1	RBM6
Frequency of depressed mood in last 2 weeks	8.0	1	0	0.0	1	RBM6
Long-standing illness, disability or infirmity	8.0	1	0	0.0	1	RBM6
Impedance of leg (left)	7.8	1	1	2.2	1	RBM6
Trunk fat-free mass	7.8	1	1	2.2	1	RBM6
Qualifications: nursing, teaching	7.8	1	0	0.0	1	RBM6
Illnesses of siblings	7.7	1	0	0.0	1	RBM6
Loneliness, isolation	7.7	1	0	0.0	1	RBM6
Trunk predicted mass	7.6	1	1	2.2	1	RBM6
High blood pressure (siblings)	7.6	1	0	0.0	1	RBM6
Leg fat-free mass (right)	7.4	1	1	2.2	1	RBM6
Number of self-reported non-cancer illnesses	7.3	1	0	0.0	1	RBM6
Leg predicted mass (right)	7.2	1	1	2.2	1	RBM6
Impedance of leg (right)	7.0	1	1	2.2	1	RBM6
Hair/balding pattern: Pattern 3	7.0	1	0	0.0	1	RBM6
Crohns Disease (2012)	6.8	1	0	0.0	1	RBM6
Irritable Bowel Disease (IBD)	6.7	1	0	0.0	1	RBM6
Diastolic blood pressure, automated reading	6.5	1	0	0.0	1	RBM6
Chronotype (morning person)	6.1	1	0	0.0	1	RBM6
Blood White Count	5.0	1	1	2.2	1	RBM6
Smoking Status	4.6	1	0	0.0	1	RBM6
Blood Eosinophil Count	3.9	1	1	2.2	1	RBM6
Forced vital capacity (FVC), Best measure	3.9	1	0	0.0	1	RBM6
Lung FVC	3.4	1	0	0.0	1	RBM6
Forced expiratory volume in 1-second (FEV1), Best measure	3.4	1	0	0.0	1	RBM6
Forced vital capacity (FVC)	2.7	1	0	0.0	1	RBM6
Comparative height size at age 10	2.1	1	0	0.0	1	RBM6
Heel T-Score	2.0	1	0	0.0	1	RBM6

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Uterus	0	0.000	1.4
GTEx	Adipose Visceral Omentum	1	0.049	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Aorta	2	0.067	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Colon Sigmoid	1	0.068	1.3
GTEx	Esophagus Muscularis	1	0.031	1.3
GTEx	Lung	1	0.035	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Small Intestine Terminal Ileum	1	0.217	1.3
GTEx	Testis	0	0.000	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Artery Tibial	2	0.053	1.2
GTEx	Brain Caudate basal ganglia	1	0.109	1.2
GTEx	Brain Cerebellum	3	0.151	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	1	0.051	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	1	0.061	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Esophagus Mucosa	1	0.030	1.2
GTEx	Heart Atrial Appendage	1	0.063	1.2
GTEx	Heart Left Ventricle	1	0.065	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Muscle Skeletal	1	0.035	1.2
GTEx	Nerve Tibial	2	0.046	1.2
GTEx	Pancreas	1	0.061	1.2
GTEx	Pituitary	1	0.090	1.2
GTEx	Prostate	1	0.120	1.2
GTEx	Skin Sun Exposed Lower leg	1	0.027	1.2
GTEx	Spleen	1	0.071	1.2
GTEx	Stomach	0	0.000	1.2
GTEx	Thyroid	1	0.025	1.2
GTEx	Vagina	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	2	0.046	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	1	0.024	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.090	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.1
METSIM	Adipose	0	0.000	1.1
NTR	Blood	1	0.042	1.1
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.1
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.1
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.1