Hub : Traits :

Ever highly irritable/argumentative for 2 days

37 significantly associated models · 7 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 49016056 51043528 7 1 9.7e-09 6.4e-08 0.049 87 RBM6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 14.6 1 1 2.2 0 1 RBM6
Intelligence (Savage-Jansen 2018) 18.2 1 1 2.2 0 1 RBM6
Neuroticism (Nagel 2018) 10.1 1 0 0.0 0 1 RBM6
Schizophrenia vs Biploar Disorder 10.8 1 0 0.0 0 1 RBM6
Irritable Bowel Disease (IBD) 6.7 1 0 0.0 0 1 RBM6
Ulcerative Colitis (UC) 9.8 1 0 0.0 0 1 RBM6
Verbal and Numeric Reasoning (VNR) 16.4 1 1 2.2 0 1 RBM6
Age at First Birth 34.1 1 1 2.2 0 1 RBM6
Body Mass Index (BMI) (2010) 8.0 1 0 0.0 0 1 RBM6
Crohns Disease (2012) 6.8 1 0 0.0 0 1 RBM6
HDL Cholesterol 8.1 1 0 0.0 0 1 RBM6
Ulcerative Colitis 8.1 1 0 0.0 0 1 RBM6
Blood Eosinophil Count 3.9 1 1 2.2 0 1 RBM6
Blood White Count 5.0 1 1 2.2 0 1 RBM6
Heel T-Score 2.0 1 0 0.0 0 1 RBM6
BMI 24.0 1 1 2.2 0 1 RBM6
Smoking Status 4.6 1 0 0.0 0 1 RBM6
Respiratory disease 9.7 1 0 0.0 0 1 RBM6
Type 2 Diabetes (T2D) (2018) 13.2 1 0 0.0 0 1 RBM6
Lung FVC 3.4 1 0 0.0 0 1 RBM6
Neuroticism 12.5 1 1 2.2 0 1 RBM6
Chronotype (morning person) 6.1 1 0 0.0 0 1 RBM6
Number of treatments/medications taken 18.9 1 1 2.2 0 1 RBM6
Frequency of depressed mood in last 2 weeks 8.0 1 0 0.0 0 1 RBM6
Relative age of first facial hair 10.4 1 0 0.0 0 1 RBM6
Medication: Co-codamol 17.8 1 0 0.0 0 1 RBM6
Impedance of leg (right) 7.0 1 1 2.2 0 1 RBM6
Leg fat-free mass (left) 9.0 1 1 2.2 0 1 RBM6
Trunk fat percentage 9.3 1 1 2.2 0 1 RBM6
Fed-up feelings 11.6 1 0 0.0 0 1 RBM6
Frequency of unenthusiasm / disinterest in last 2 weeks 10.4 1 0 0.0 0 1 RBM6
Taking other prescription medications 25.8 1 1 2.2 0 1 RBM6
Bilateral oophorectomy (both ovaries removed) 9.8 1 0 0.0 0 1 RBM6
Qualifications: CSEs or equivalent 9.8 1 0 0.0 0 1 RBM6
Chronic bronchitis/emphysema (father) 11.0 1 0 0.0 0 1 RBM6
Body mass index (BMI) 27.9 1 1 2.2 0 1 RBM6
Impedance of leg (left) 7.8 1 1 2.2 0 1 RBM6
Leg predicted mass (left) 9.0 1 1 2.2 0 1 RBM6
Trunk fat mass 13.8 1 1 2.2 0 1 RBM6
Waist circumference 18.1 1 1 2.2 0 1 RBM6
Frequency of tenseness / restlessness in last 2 weeks 10.4 1 0 0.0 0 1 RBM6
Forced vital capacity (FVC) 2.7 1 0 0.0 0 1 RBM6
Ever unenthusiastic/disinterested for a whole week 19.7 1 0 0.0 0 1 RBM6
Qualifications: None of the above 20.8 1 1 2.2 0 1 RBM6
Diabetes (self-reported) 15.4 1 0 0.0 0 1 RBM6
Fluid intelligence score 18.8 1 1 2.2 0 1 RBM6
Illnesses of siblings 7.7 1 0 0.0 0 1 RBM6
Neuroticism score 14.7 1 1 2.2 0 1 RBM6
Weight 17.2 1 1 2.2 0 1 RBM6
Impedance of arm (right) 21.4 1 1 2.2 0 1 RBM6
Arm fat percentage (right) 15.7 1 1 2.2 0 1 RBM6
Trunk fat-free mass 7.8 1 1 2.2 0 1 RBM6
Hip circumference 10.6 1 1 2.2 0 1 RBM6
Alcohol intake versus 10 years previously 13.7 1 0 0.0 0 1 RBM6
Hair/balding pattern: Pattern 3 7.0 1 0 0.0 0 1 RBM6
Number of live births 11.7 1 0 0.0 0 1 RBM6
Qualifications: A levels/AS levels or equivalent 25.7 1 1 2.2 0 1 RBM6
Mouth/teeth dental problems: Dentures 10.3 1 0 0.0 0 1 RBM6
Asthma 8.1 1 0 0.0 0 1 RBM6
Forced expiratory volume in 1-second (FEV1), Best measure 3.4 1 0 0.0 0 1 RBM6
Impedance of arm (left) 21.6 1 1 2.2 0 1 RBM6
Arm fat mass (right) 20.8 1 1 2.2 0 1 RBM6
Trunk predicted mass 7.6 1 1 2.2 0 1 RBM6
Exposure to tobacco smoke at home 17.7 1 0 0.0 0 1 RBM6
Breastfed as a baby 8.8 1 0 0.0 0 1 RBM6
Seen doctor (GP) for nerves, anxiety, tension or depression 8.9 1 0 0.0 0 1 RBM6
Medication: Ventolin 100micrograms inhaler 10.7 1 0 0.0 0 1 RBM6
Chronic bronchitis/emphysema (mother) 14.2 1 0 0.0 0 1 RBM6
High blood pressure (siblings) 7.6 1 0 0.0 0 1 RBM6
Forced vital capacity (FVC), Best measure 3.9 1 0 0.0 0 1 RBM6
Body fat percentage 13.6 1 1 2.2 0 1 RBM6
Leg fat percentage (right) 22.3 1 1 2.2 0 1 RBM6
Arm fat-free mass (right) 12.4 1 1 2.2 0 1 RBM6
Exposure to tobacco smoke outside home 12.5 1 0 0.0 0 1 RBM6
Wheeze or whistling in the chest in last year 17.3 1 1 2.2 0 1 RBM6
Age at first live birth 29.1 1 1 2.2 0 1 RBM6
Health satisfaction 8.4 1 0 0.0 0 1 RBM6
Qualifications: College or University degree 29.6 1 1 2.2 0 1 RBM6
Medication: Seretide 50 evohaler 14.0 1 0 0.0 0 1 RBM6
Whole body fat mass 18.5 1 1 2.2 0 1 RBM6
Leg fat mass (right) 25.3 1 1 2.2 0 1 RBM6
Arm predicted mass (right) 13.5 1 1 2.2 0 1 RBM6
Alcohol intake frequency. 10.0 1 0 0.0 0 1 RBM6
Comparative height size at age 10 2.1 1 0 0.0 0 1 RBM6
Number of full sisters 12.5 1 0 0.0 0 1 RBM6
Overall health rating 22.6 1 1 2.2 0 1 RBM6
Age at last live birth 36.2 1 1 2.2 0 1 RBM6
Leg pain on walking 9.0 1 0 0.0 0 1 RBM6
Qualifications: NVQ or HND or HNC or equivalent 9.7 1 0 0.0 0 1 RBM6
Knee pain experienced in last month 8.3 1 0 0.0 0 1 RBM6
Illnesses of siblings: Diabetes 11.3 1 0 0.0 0 1 RBM6
Whole body fat-free mass 9.1 1 1 2.2 0 1 RBM6
Leg fat-free mass (right) 7.4 1 1 2.2 0 1 RBM6
Arm fat percentage (left) 15.3 1 1 2.2 0 1 RBM6
Average weekly red wine intake 10.7 1 0 0.0 0 1 RBM6
Mood swings 16.9 1 1 2.2 0 1 RBM6
Loneliness, isolation 7.7 1 0 0.0 0 1 RBM6
Long-standing illness, disability or infirmity 8.0 1 0 0.0 0 1 RBM6
Ever had bowel cancer screening 10.9 1 0 0.0 0 1 RBM6
Diabetes diagnosed by doctor 12.5 1 0 0.0 0 1 RBM6
Qualifications: nursing, teaching 7.8 1 0 0.0 0 1 RBM6
Asthma (self-reported) 8.2 1 0 0.0 0 1 RBM6
Whole body water mass 9.4 1 1 2.2 0 1 RBM6
Leg predicted mass (right) 7.2 1 1 2.2 0 1 RBM6
Arm fat mass (left) 20.8 1 1 2.2 0 1 RBM6
Number of self-reported non-cancer illnesses 7.3 1 0 0.0 0 1 RBM6
Miserableness 28.0 1 1 2.2 0 1 RBM6
Guilty feelings 10.1 1 0 0.0 0 1 RBM6
Financial situation satisfaction 8.5 1 0 0.0 0 1 RBM6
Basal metabolic rate 11.6 1 1 2.2 0 1 RBM6
Leg fat percentage (left) 21.7 1 1 2.2 0 1 RBM6
Arm fat-free mass (left) 14.5 1 1 2.2 0 1 RBM6
Number of operations (self-reported) 12.7 1 0 0.0 0 1 RBM6
Average weekly beer plus cider intake 20.8 1 1 2.2 0 1 RBM6
Age started oral contraceptive pill 11.8 1 0 0.0 0 1 RBM6
Diastolic blood pressure, automated reading 6.5 1 0 0.0 0 1 RBM6
Ever depressed for a whole week 19.0 1 0 0.0 0 1 RBM6
Pain experienced in last month 9.2 1 0 0.0 0 1 RBM6
Impedance of whole body 16.5 1 1 2.2 0 1 RBM6
Leg fat mass (left) 25.4 1 1 2.2 0 1 RBM6
Arm predicted mass (left) 14.8 1 1 2.2 0 1 RBM6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 1 0.049 1.3
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 2 0.067 1.3
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 2 0.053 1.2
GTEx Brain Caudate basal ganglia 1 0.109 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 3 0.151 1.2
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.1
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 1 0.051 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 1 0.061 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 1 0.068 1.3
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 1 0.030 1.2
GTEx Esophagus Muscularis 1 0.031 1.3
GTEx Heart Atrial Appendage 1 0.063 1.2
GTEx Heart Left Ventricle 1 0.065 1.2
GTEx Liver 0 0.000 1.2
GTEx Lung 1 0.035 1.3
GTEx Muscle Skeletal 1 0.035 1.2
GTEx Nerve Tibial 2 0.046 1.2
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 1 0.061 1.2
GTEx Pituitary 1 0.090 1.2
GTEx Prostate 1 0.120 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 1 0.027 1.2
GTEx Small Intestine Terminal Ileum 1 0.217 1.3
GTEx Spleen 1 0.071 1.2
GTEx Stomach 0 0.000 1.2
GTEx Testis 0 0.000 1.3
GTEx Thyroid 1 0.025 1.2
GTEx Uterus 0 0.000 1.4
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.1
NTR Blood 1 0.042 1.1
ROSMAP Brain Pre-frontal Cortex 2 0.046 1.2
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 1 0.091 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 1 0.024 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 1 0.023 1.1
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.090 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.075 1.1
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.1
The Cancer Genome Atlas Thyroid Carcinoma 1 0.019 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2