Best TWAS P=4.08e-09 · Best GWAS P=1.68e-08 conditioned to 0.443
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SCAI | 0.04 | 0.00 | enet | 8 | 0.02 | 4.2e-03 | 1.9 | -5.2 | 2.1e-07 | -0.61 | 0.07 | 0.67 | FALSE |
2 | GTEx | Adipose Subcutaneous | GOLGA1 | 0.04 | 0.05 | lasso | 1 | 0.05 | 8.6e-05 | 5.2 | 5.2 | 2.5e-07 | 0.85 | 0.06 | 0.91 | FALSE |
3 | GTEx | Adipose Subcutaneous | SCAI | 0.07 | 0.05 | lasso | 4 | 0.02 | 7.4e-03 | 5.5 | -5.9 | 4.1e-09 | -0.90 | 0.04 | 0.95 | TRUE |
4 | GTEx | Brain Caudate basal ganglia | OLFML2A | 0.12 | 0.10 | lasso | 4 | 0.03 | 3.7e-02 | 5.4 | 5.3 | 9.5e-08 | 0.82 | 0.04 | 0.82 | FALSE |
5 | GTEx | Brain Cerebellar Hemisphere | ARPC5L | 0.21 | 0.34 | lasso | 2 | 0.32 | 6.1e-09 | 5.2 | -5.2 | 1.7e-07 | -0.84 | 0.06 | 0.94 | FALSE |
6 | GTEx | Brain Cerebellum | ARPC5L | 0.31 | 0.37 | enet | 7 | 0.27 | 1.5e-08 | 5.3 | 5.3 | 9.8e-08 | 0.84 | 0.05 | 0.95 | FALSE |
7 | GTEx | Cells EBV-transformed lymphocytes | GOLGA1 | 0.13 | 0.00 | enet | 8 | 0.06 | 3.8e-03 | 3.7 | 5.1 | 3.1e-07 | 0.74 | 0.26 | 0.40 | FALSE |
8 | GTEx | Colon Transverse | GOLGA1 | 0.10 | 0.13 | lasso | 1 | 0.09 | 5.9e-05 | 5.2 | 5.2 | 2.0e-07 | 0.84 | 0.07 | 0.92 | FALSE |
9 | GTEx | Esophagus Muscularis | PPP6C | 0.05 | 0.03 | lasso | 3 | 0.01 | 1.2e-01 | 5.4 | -5.4 | 7.0e-08 | -0.80 | 0.06 | 0.59 | FALSE |
10 | GTEx | Esophagus Muscularis | RABEPK | 0.12 | 0.01 | enet | 19 | 0.08 | 1.3e-05 | -4.1 | -5.2 | 1.8e-07 | -0.61 | 0.10 | 0.70 | FALSE |
11 | GTEx | Muscle Skeletal | GOLGA1 | 0.07 | 0.02 | lasso | 4 | 0.02 | 2.2e-03 | 5.4 | 5.6 | 1.7e-08 | 0.87 | 0.06 | 0.91 | FALSE |
12 | GTEx | Nerve Tibial | GOLGA1 | 0.07 | 0.04 | lasso | 2 | 0.03 | 5.6e-03 | 5.6 | 5.5 | 4.8e-08 | 0.75 | 0.03 | 0.85 | FALSE |
13 | GTEx | Skin Sun Exposed Lower leg | PPP6C | 0.11 | 0.10 | lasso | 5 | 0.09 | 9.1e-08 | 5.0 | -5.1 | 3.0e-07 | -0.83 | 0.21 | 0.79 | FALSE |
14 | GTEx | Spleen | PRPS1P2 | 0.18 | 0.02 | lasso | 4 | 0.04 | 3.9e-02 | 4.9 | 5.6 | 1.9e-08 | 0.79 | 0.09 | 0.26 | FALSE |
15 | GTEx | Thyroid | ARPC5L | 0.18 | 0.12 | enet | 17 | 0.16 | 1.5e-12 | 5.5 | 5.5 | 4.4e-08 | 0.84 | 0.04 | 0.96 | FALSE |
16 | METSIM | Adipose | ARPC5L | 0.02 | 0.01 | blup | 270 | 0.02 | 1.5e-03 | 4.9 | 5.3 | 1.2e-07 | 0.90 | 0.06 | 0.88 | FALSE |
17 | ROSMAP | Brain Pre-frontal Cortex | PPP6C | 0.11 | 0.19 | lasso | 5 | 0.20 | 8.6e-26 | 5.0 | -5.2 | 1.7e-07 | -0.85 | 0.21 | 0.78 | FALSE |
18 | ROSMAP | Brain Pre-frontal Cortex | GOLGA1 | 0.08 | 0.07 | bslmm | 281 | 0.07 | 2.3e-09 | 5.2 | 5.3 | 1.2e-07 | 0.82 | 0.06 | 0.94 | FALSE |
19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | OLFML2A | 0.06 | 0.03 | blup | 33 | 0.03 | 1.6e-04 | 5.4 | -5.4 | 7.6e-08 | -0.71 | 0.00 | 0.99 | FALSE |
20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SCAI | 0.02 | 0.02 | blup | 94 | 0.01 | 2.1e-02 | 5.2 | -5.6 | 1.8e-08 | -0.90 | 0.03 | 0.82 | FALSE |