TWAS hub - SFTPA2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.224	0.0390	0.0e+00	0.158	0.196	0.187	0.202	0.175	8.0e-20	1.3e-24	1.7e-23	2.3e-25	5.6e-22
2	TCGA	Breast Invasive Carcinoma	0.063	0.0410	9.9e-09	0.029	0.042	0.044	NA	0.038	1.3e-06	5.7e-09	2.1e-09	NA	2.5e-08
3	TCGA	Esophageal Carcinoma	0.542	0.2060	6.9e-03	-0.007	0.077	0.130	NA	0.072	6.6e-01	1.9e-03	6.6e-05	NA	2.7e-03
4	TCGA	Brain Lower Grade Glioma	0.139	0.0658	5.0e-10	0.084	0.093	0.104	NA	0.098	7.7e-10	1.1e-10	7.6e-12	NA	3.0e-11
5	TCGA	Thyroid Carcinoma	0.075	0.0420	5.6e-05	0.047	0.049	0.056	NA	0.053	2.2e-05	1.3e-05	3.8e-06	NA	6.3e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Hand grip strength (right)	10.0	27.0	54.4	-5.1	-6.8	-2.1	-7.4	2.0
Sitting height	6.6	47.0	77.6	-7.1	-8.8	-3.7	-8.8	4.1
HbA1C	6.4	7.1	16.6	1.6	4.1	-2.3	2.6	-1.9
Hand grip strength (left)	6.0	15.7	31.1	-3.9	-5.1	-2.1	-5.6	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	5.7	6.6	11.0	3.3	3.3	1.8	2.9	-0.5
Diabetes (mother)	4.4	5.6	13.5	-2.3	-2.3	-3.7	-1.9	0.3
Forced vital capacity (FVC)	3.8	14.7	24.2	-3.6	-4.9	-1.9	-4.9	2.9
Chronic bronchitis/emphysema (father)	3.6	4.2	5.9	-2.4	-2.4	-0.3	-2.1	2.1
Hair/balding pattern: Pattern 3	3.3	4.9	7.4	2.7	2.7	1.7	2.2	-1.5
Medication: Lansoprazole	3.0	3.4	8.4	1.7	2.2	0.4	2.9	0.9
Lupus	2.9	4.4	9.7	1.9	2.5	3.1	1.5	0.2
Forced vital capacity (FVC), Best measure	2.9	10.8	20.2	-2.9	-4.2	-1.8	-4.5	2.0
Type 2 Diabetes (T2D) (2012)	2.7	3.2	9.3	-3.0	-2.6	0.0	0.0	0.0
Lung FEV1/FVC ratio	2.6	13.1	24.6	5.0	3.4	-2.4	3.2	-3.6
Trunk fat-free mass	2.6	14.9	19.7	-4.2	-4.3	-3.9	-4.4	1.9
Trunk predicted mass	2.6	14.8	20.1	-4.1	-4.3	-3.9	-4.5	1.8
Knee pain experienced in last month	2.6	4.1	6.1	2.1	2.2	2.5	2.2	0.3
Arm predicted mass (left)	2.6	13.4	18.6	-4.3	-4.0	-3.5	-3.9	2.2
Exposure to tobacco smoke at home	2.5	2.8	4.8	-1.7	-2.0	-0.9	-1.2	2.2
Heart disease (mother)	2.5	3.1	7.6	-1.7	-1.3	-1.7	-0.7	2.8
Hearing difficulty/problems: Yes	2.4	3.6	5.3	1.8	2.3	2.1	2.3	-0.0
Number of live births	2.4	3.4	7.6	2.0	2.1	0.7	2.8	-0.9
Arm predicted mass (right)	2.4	12.0	16.2	-4.0	-3.7	-3.5	-3.5	2.4
Hair/balding pattern: Pattern 2	2.3	2.9	5.2	-1.4	-2.3	-1.5	-1.8	1.5
Standing height	2.3	22.9	41.6	-5.2	-5.7	-3.1	-6.5	2.1
Headache pain in last month	2.3	3.9	7.1	2.7	2.4	1.5	2.1	0.2
Supplements: Calcium	2.3	2.5	5.1	1.6	2.1	0.5	2.3	0.5
LDL Cholesterol	2.2	3.5	7.0	2.7	2.3	0.7	1.7	-1.4
Noisy workplace	2.2	2.7	6.2	2.5	1.4	0.9	1.9	1.0
Arm fat-free mass (right)	2.2	11.1	14.0	-3.7	-3.5	-3.5	-3.4	2.2
Breast cancer (self-reported)	2.2	2.7	4.9	-2.2	-1.7	-0.2	-1.7	1.6
Whole body water mass	2.2	12.7	15.5	-3.9	-3.9	-3.6	-3.9	2.0
Arm fat-free mass (left)	2.2	11.4	15.7	-4.0	-3.7	-3.1	-3.7	2.1
Pain experienced in last month	2.2	3.6	5.9	-2.4	-2.4	-1.8	-1.8	0.1
Whole body fat-free mass	2.1	12.0	14.8	-3.8	-3.8	-3.6	-3.9	1.9
Pain all over the body in last month	2.0	2.1	3.6	1.6	1.9	0.6	1.4	-1.5
Medication: Paracetamol	2.0	3.1	6.5	2.5	2.2	1.4	1.4	-0.6
Migraine (self-reported)	1.9	2.3	4.5	1.4	1.8	2.1	1.0	0.9
Medication: Paracetamol	1.8	3.0	6.3	2.5	2.1	1.7	1.3	-0.3
Age at last live birth	1.8	2.6	4.6	1.5	1.7	2.2	1.7	0.7
Leg fat-free mass (right)	1.8	9.6	12.2	-3.4	-3.3	-3.5	-3.2	1.9
Leg predicted mass (right)	1.8	9.7	11.7	-3.4	-3.3	-3.4	-3.2	2.1
Basal metabolic rate	1.8	10.1	12.7	-3.6	-3.4	-3.3	-3.5	1.8
Forced expiratory volume in 1-second (FEV1)	1.7	5.7	10.0	-1.7	-3.2	-2.1	-3.2	1.2
Pulse wave Arterial Stiffness index	1.7	2.0	3.9	-1.5	-1.2	-2.0	-0.1	1.5
Unable to work because of sickness or disability	1.7	2.2	6.1	-0.8	-1.5	-2.5	-1.3	0.5
Average weekly fortified wine intake	1.6	1.9	3.7	-1.5	-1.9	0.2	-0.7	1.7
Had menopause	1.6	2.0	4.5	-2.1	-1.2	-1.9	-0.4	0.7
Prospective memory result	1.6	1.9	6.7	0.7	0.7	-2.6	0.8	-1.2
Mean time to correctly identify matches	1.6	3.0	12.6	0.9	1.0	-0.1	0.6	-3.5
Illnesses of father: Heart disease	1.6	2.2	4.5	0.5	1.7	0.0	1.9	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.8	4.1	-1.5	-1.5	-0.5	-2.0	0.2
Primary Biliary Cirrhosis	1.5	2.2	7.9	1.0	0.9	-1.1	0.4	-2.8
Severe depression (siblings)	1.5	1.6	2.9	-1.7	-1.6	0.2	-1.5	0.8
Wheeze or whistling in the chest in last year	1.5	2.7	10.1	-1.0	-0.0	1.5	0.4	3.2
Health satisfaction	1.5	1.9	6.4	-0.1	-0.2	1.7	0.4	2.5
Medication: Ibuprofen	1.5	1.8	8.0	0.7	0.3	2.8	0.3	0.8
Mineral and other dietary supplements	1.5	2.1	3.2	1.8	1.5	-1.0	1.5	-1.2
Heel T-Score	1.4	11.3	19.0	3.9	3.5	-1.2	4.4	-2.9
Systolic Blood Pressure	1.4	6.8	9.7	-3.0	-3.1	-1.9	-2.6	2.3
Leg fat-free mass (left)	1.4	7.2	9.9	-2.9	-2.7	-3.1	-2.8	1.6
Leg predicted mass (left)	1.4	7.2	10.2	-2.9	-2.7	-3.2	-2.7	1.6
Medication: Co-codamol	1.3	1.5	2.8	-1.1	-1.5	-0.0	-1.7	1.0
Tinnitus: Yes, but not now, but have in the past	1.3	1.3	2.5	0.5	1.3	1.5	1.6	-0.5
Financial difficulties in last 2 years	1.3	1.8	3.9	2.0	1.2	1.6	1.0	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	7.0	0.8	0.3	2.6	0.4	0.7
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	3.7	-1.5	-1.6	-0.6	-1.9	-1.1
Birth weight	1.3	2.8	5.6	-1.4	-2.4	0.9	-2.3	0.7
Shortness of breath walking on level ground	1.3	1.5	3.5	0.1	1.1	1.9	1.1	1.3
Medication for pain relief, constipation, heartburn	1.3	2.1	3.1	-1.8	-1.8	-1.6	-1.0	0.9
Illnesses of siblings: Diabetes	1.3	1.7	3.2	-1.5	-0.4	-1.8	-0.0	-1.6
Medication: Bendroflumethiazide	1.3	2.0	9.0	-0.1	0.8	-3.0	0.2	-0.6
Medication: Lisinopril	1.3	1.6	3.5	0.0	0.6	-1.9	1.6	1.4
Height	1.2	22.7	31.0	-5.6	-5.3	-3.2	-5.5	3.6
Serious illness, injury or assault to yourself	1.2	1.5	3.8	-1.9	-1.0	-1.1	-0.7	1.1
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.5	0.4	0.7	2.1	0.3	1.3
Had other major operations	1.2	1.5	5.4	0.4	0.8	2.3	1.0	-0.7
Impedance of arm (right)	1.2	5.5	12.9	2.4	2.2	3.6	1.5	-1.5
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.4	-1.8	-0.2	1.0	-0.2	1.8
Pulse wave peak to peak time	1.2	1.4	3.0	1.0	0.9	1.7	-0.2	-1.4
Number of full sisters	1.2	1.5	3.7	-0.6	-1.2	-1.0	-0.8	1.9
Osteoarthritis (self-reported)	1.2	1.5	3.0	1.7	1.1	-1.4	1.2	-0.2
Fractured/broken bones in last 5 years	1.2	1.5	3.9	-1.0	-1.2	1.1	-2.0	0.1
Vascular/heart problems diagnosed by doctor	1.2	3.2	9.7	-0.5	-1.2	3.1	-2.0	-0.7
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	4.6	1.1	1.0	2.1	0.4	0.4
Reaction Time	1.1	2.1	9.5	0.5	0.6	0.7	0.0	-3.1
Medication for hormone replacement therapy	1.1	1.2	2.3	-1.5	-1.4	-0.5	-0.9	0.7
Impedance of leg (right)	1.1	5.4	11.8	2.3	2.2	3.4	1.6	-1.5
High blood pressure	1.1	3.0	7.7	0.6	1.4	-2.8	2.2	0.6
Multivitamins +/- minerals	1.1	1.5	2.4	-0.7	-1.0	1.5	-1.3	1.4
Supplements: Glucosamine	1.1	1.5	2.9	-1.4	-1.7	-0.3	-1.4	0.5
Mouth/teeth dental problems: Dentures	1.1	1.8	4.0	-0.7	-0.9	-1.1	-1.6	-2.0
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.6	-1.2	-1.9	0.5	-1.9	0.5
Glaucoma (self-reported)	1.1	1.3	2.6	1.3	1.1	1.6	0.5	-0.9
Neck or shoulder pain in last month	1.1	1.5	5.4	0.1	0.2	1.5	0.1	2.3
Comparative height size at age 10	1.1	6.0	10.8	-2.8	-3.0	-1.4	-3.3	0.5
Hypertension (Self-reported)	1.1	3.0	10.9	0.2	1.1	-3.3	1.7	0.2
Wears glasses or contact lenses	1.1	1.2	4.9	0.4	0.9	-0.3	0.4	-2.2
Eye problems/disorders: Glaucoma	1.1	1.3	2.3	1.2	1.5	1.3	0.8	-0.6
Respiratory disease	1.0	2.2	6.7	-1.9	-0.9	0.3	-0.3	2.6
Medication: Levothyroxine sodium	1.0	1.6	2.5	1.2	1.6	1.4	1.3	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	6.4	-0.7	-2.4	-1.9	-2.5	0.5
Impedance of arm (left)	1.0	4.7	9.4	2.3	2.1	3.1	1.4	-1.6
Tense / ‘highly strung’	1.0	1.7	3.2	-1.5	-0.8	-0.3	-1.4	1.8
Birth weight of first child	1.0	1.8	5.9	-0.5	-1.6	0.5	-2.4	0.3
Worry too long after embarrassment	1.0	1.6	3.4	1.1	1.8	1.3	1.4	-0.2
Medication: Omeprazole	1.0	1.2	4.5	0.9	0.7	2.1	0.2	0.4
Alcohol intake frequency.	1.0	2.4	3.7	1.7	1.9	0.4	1.5	-1.6
Leg pain on walking	1.0	1.2	3.6	0.6	0.6	1.9	0.8	1.1
Heart disease (siblings)	1.0	1.2	3.8	-0.5	0.7	-1.1	0.3	-2.0
Impedance of whole body	1.0	4.9	11.8	2.2	2.0	3.4	1.3	-1.4
Blood Platelet Count	0.9	10.3	18.4	4.3	3.6	4.3	1.2	-0.5
Smoking Status	0.9	2.2	3.3	-1.8	-1.8	-0.9	-1.5	1.3
Cardiovascular Disease	0.9	2.9	11.4	-0.7	0.6	-3.4	1.0	1.2
Sensitivity / hurt feelings	0.9	1.5	2.7	0.5	1.6	1.5	0.7	-1.4
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	4.2	-0.5	0.3	-0.6	0.8	2.0
Medication: Simvastatin	0.9	1.4	4.0	0.1	1.0	-2.0	1.2	-0.6
Worrier / anxious feelings	0.9	1.7	3.0	1.7	1.6	1.0	1.1	-0.7
Had major operations	0.9	1.0	3.4	0.5	-0.6	-1.8	-1.0	-0.2
Financial situation satisfaction	0.9	1.1	2.4	0.9	1.1	0.5	1.6	1.0
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.2	-1.4	-1.5	0.3	-1.0	0.9
Bipolar Disorder (2018)	0.8	1.3	4.6	-1.4	-2.2	0.0	0.0	0.0
Crohns Disease (2017)	0.8	1.8	6.1	2.5	1.2	0.8	0.6	-0.7
Prostate Cancer	0.8	1.2	2.0	-0.2	1.4	1.1	1.4	0.8
Crohns Disease (2012)	0.8	1.4	2.7	1.6	1.1	-0.1	0.6	-1.6
Ever had hysterectomy (womb removed)	0.8	0.9	1.2	0.7	1.1	1.1	0.6	-1.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.8	1.3	1.3	-0.8	0.7	0.1
Fed-up feelings	0.8	1.5	3.4	1.3	1.8	0.1	0.9	-1.1
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	3.4	-0.6	0.0	0.8	0.3	1.8
Alcohol usually taken with meals	0.8	1.4	3.2	1.8	1.3	-0.2	0.8	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.6	-1.1	-0.4	1.1	-0.3	1.9
Pulse rate	0.8	1.3	2.8	0.9	0.9	1.2	0.6	1.7
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.8	1.1	0.8	-0.5	1.7	0.5
Loud music exposure frequency	0.8	0.9	3.9	0.4	0.4	2.0	0.5	-0.3
Medication: Seretide 50 evohaler	0.8	0.9	2.4	-0.3	0.2	1.4	0.3	1.5
Medication: Aspirin	0.8	1.0	2.0	-1.3	0.0	-1.4	0.1	-1.2
Supplements: Vitamin C	0.8	0.9	1.8	1.3	1.1	0.5	0.7	-0.8
Eye problems/disorders: Cataract	0.8	0.9	1.4	0.6	1.2	-0.2	1.2	1.2
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	4.2	1.2	0.8	2.1	0.6	0.1
Medication: Aspirin	0.8	1.0	2.0	-1.4	-0.1	-1.4	-0.1	-1.0
Medication: Gliclazide	0.8	0.9	2.8	-1.1	-0.2	-1.7	-0.4	-0.3
Alcohol drinker status: Never	0.8	0.9	3.5	0.1	0.8	1.9	0.5	0.2
Number of operations (self-reported)	0.8	1.2	1.8	1.3	1.3	0.9	1.2	-0.6
Commuting to job workplace: Cycle	0.8	1.0	3.9	0.8	0.6	2.0	0.1	0.5
Cholesterol lowering medication	0.8	1.2	4.6	-0.5	0.3	-2.1	0.1	0.9
Lung FVC	0.7	3.4	7.3	-1.3	-2.7	-1.2	-2.4	0.8
Impedance of leg (left)	0.7	3.3	9.3	1.7	1.5	3.0	0.9	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	3.0	1.7	1.2	0.0	1.6	-0.7
Illnesses of siblings	0.7	1.0	2.7	0.7	-0.6	1.1	-0.6	1.6
Weight	0.7	3.4	5.4	-2.3	-1.7	-1.9	-1.8	1.2
Arm fat percentage (right)	0.7	2.8	5.5	1.5	2.3	1.2	2.0	-0.8
Asthma	0.7	1.4	4.2	-1.5	-0.5	0.2	-0.5	2.0
Medication: Cholesterol lowering	0.7	1.0	2.2	0.8	1.5	-0.3	1.5	0.3
Length of working week for main job	0.7	0.7	1.7	0.6	0.8	0.9	0.4	-1.3
Family relationship satisfaction	0.7	0.9	2.0	1.4	0.8	0.3	1.1	0.7
Asthma (self-reported)	0.7	1.5	4.9	-1.5	-0.4	0.2	-0.3	2.2
Number of self-reported non-cancer illnesses	0.7	1.2	2.2	0.4	1.5	-1.2	1.4	0.6
Medication: Blood pressure	0.7	1.4	5.2	0.3	1.0	-2.3	0.7	0.4
Medication: Atorvastatin	0.7	0.9	2.1	-0.7	-0.7	-0.4	-1.1	1.4
Basal cell carcinoma (self-reported)	0.7	0.8	1.8	0.4	1.1	0.8	1.4	0.5
Intelligence (Savage-Jansen 2018)	0.6	2.0	4.3	-2.1	-1.4	-0.7	-1.6	0.7
Ulcerative Colitis (UC)	0.6	1.1	2.0	0.1	-1.4	0.4	-1.3	1.2
Breast Cancer	0.6	1.5	3.5	-0.6	-1.9	0.5	-1.5	1.2
Coronary Artery Disease (CAD)	0.6	0.7	2.2	1.1	1.5	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.2	-1.5	-0.6	-1.4	-0.7	0.6
Number of treatments/medications taken	0.6	1.1	2.9	0.8	1.7	0.2	1.4	-0.1
Systolic blood pressure, automated reading	0.6	1.8	2.8	-1.7	-1.5	-1.0	-0.6	1.6
Stomach or abdominal pain in last month	0.6	0.7	1.7	0.1	0.5	1.2	0.2	1.3
Neuroticism score	0.6	1.3	2.8	1.7	1.6	0.8	0.8	-0.3
Alcohol intake versus 10 years previously	0.6	0.9	1.3	1.1	0.6	-1.1	0.9	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	2.1	1.4	1.1	0.1	1.1	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.1	-1.0	-0.8	0.4	-0.9	0.7
Illnesses of mother	0.6	0.7	3.3	0.0	0.1	1.8	0.1	-0.4
Medication: Blood pressure	0.6	1.0	2.2	0.9	1.4	-0.2	1.5	-0.5
Medication: Allopurinol	0.6	0.7	2.3	0.4	0.8	-0.3	0.8	-1.5
Overall health rating	0.6	1.2	2.1	0.4	1.1	1.4	1.4	0.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	3.1	0.6	0.3	-0.4	0.1	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.2	-0.6	-1.3	0.4	-1.5	1.4
Arm fat percentage (left)	0.6	2.4	5.2	1.3	2.3	0.8	2.0	-0.5
Average weekly red wine intake	0.6	0.8	1.8	-0.9	-0.8	0.5	-0.7	1.4
Age started oral contraceptive pill	0.6	0.7	1.2	0.6	0.5	-1.1	0.8	-1.1
Verbal and Numeric Reasoning (VNR)	0.5	1.2	3.6	-1.9	-0.9	-0.4	-1.1	-0.0
Ovarian Cancer	0.5	0.6	2.1	0.7	0.7	0.0	0.3	-1.4
Age at First Birth	0.5	0.7	3.4	0.3	0.0	-0.2	0.4	-1.9
Body Mass Index (BMI) (2010)	0.5	0.7	0.8	0.9	0.9	0.9	0.8	0.5
Maternal smoking around birth	0.5	0.7	1.3	-0.2	0.8	1.1	1.1	0.4
Nervous feelings	0.5	1.0	2.1	0.8	0.8	0.9	0.9	1.4
Allergy	0.5	1.3	2.3	1.5	0.9	-0.6	0.8	-1.4
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.7	0.0	-0.3	1.6	-0.6	-0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.1	-1.2	-1.2	0.3	-1.5	0.7
Pulse wave reflection index	0.5	0.6	1.8	-0.5	-0.6	-1.3	0.5	0.7
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.0	-0.5	-0.4	0.5	0.6	1.4
Body fat percentage	0.5	2.0	4.3	1.0	2.1	1.1	1.9	-0.2
Exposure to tobacco smoke outside home	0.5	0.6	1.1	-0.6	-1.1	-0.1	-0.6	1.1
Number of full brothers	0.5	0.6	1.4	-0.3	0.2	1.1	0.6	1.2
Age at first live birth	0.5	0.9	2.3	1.0	0.5	1.5	0.4	0.8
Mouth/teeth dental problems: Loose teeth	0.5	0.5	1.5	0.5	0.1	-1.2	-0.1	-0.9
Chest pain or discomfort	0.5	0.7	2.5	-1.6	-0.6	0.1	-0.8	-0.3
Loneliness, isolation	0.5	0.7	2.6	-0.1	0.2	-0.5	-0.7	-1.6
Osteoporosis (self-reported)	0.5	0.6	1.6	1.1	1.3	0.1	0.6	0.1
Smoking status: Current	0.5	0.8	1.2	-0.9	-1.1	-0.5	-0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	4.0	2.0	0.8	0.7	0.7	0.5
Fasting Glucose	0.4	0.4	1.7	-0.3	0.3	-0.1	-0.5	-1.3
Neuroticism (2016)	0.4	0.6	1.6	-0.0	0.5	1.0	-0.4	-1.3
Waist Hip Ratio (WHR)	0.4	1.7	3.8	1.2	1.9	0.3	1.6	-0.7
Hypothyroidism (self reported)	0.4	0.8	1.3	1.1	1.0	1.1	0.7	-0.3
Average weekly spirits intake	0.4	0.5	1.7	0.2	0.6	0.7	0.2	1.3
Vitamin and mineral supplements	0.4	0.6	2.3	-0.5	-0.6	-1.5	-0.0	0.3
Trunk fat percentage	0.4	1.7	3.5	0.8	1.9	1.3	1.7	-0.0
Qualifications: CSEs or equivalent	0.4	0.6	0.8	0.5	0.9	0.9	0.9	-0.5
Past tobacco smoking	0.4	0.7	1.0	1.0	0.8	0.7	0.8	-0.7
Diabetes (self-reported)	0.4	0.6	2.2	-0.9	0.0	-1.5	-0.0	-0.4
Falls in the last year	0.4	0.6	1.2	0.2	1.1	-0.5	0.9	-0.8
Depression (self-reported)	0.4	0.4	0.6	-0.7	-0.7	-0.8	-0.5	0.6
High blood pressure (siblings)	0.4	0.6	1.8	-1.3	-0.3	-0.7	-0.7	-0.0
Leg fat percentage (right)	0.4	1.5	3.5	0.7	1.9	0.4	1.8	-0.3
Qualifications: College or University degree	0.4	1.3	3.0	-1.7	-1.1	-0.1	-1.6	0.1
Eye problems/disorders: None of the above	0.4	0.4	1.7	0.2	-0.1	0.6	0.2	-1.3
Mood swings	0.4	0.8	1.7	0.7	0.5	1.1	0.2	1.3
Long-standing illness, disability or infirmity	0.4	0.6	1.3	-1.1	-0.2	-0.7	-0.3	0.9
Medication for cholesterol	0.4	0.6	1.4	1.0	-0.0	0.8	0.2	-1.2
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.0	0.9	0.3	1.0	-0.2	-0.6
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.8	0.9	0.9	0.6	0.8	-0.1
Ever smoked	0.4	0.6	1.1	-1.1	-0.9	0.0	-0.6	0.9
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	-0.4	-0.5	-0.0	-1.0	-1.1
Alcohol drinker status: Previous	0.4	0.4	0.8	0.4	0.5	-0.8	0.3	-0.9
Depressed Affect (Nagel 2018)	0.3	0.7	1.7	0.4	1.0	-0.6	0.5	-1.3
Irritable Bowel Disease (IBD)	0.3	0.6	2.1	1.5	-0.2	0.5	-0.6	0.6
Blood White Count	0.3	2.6	4.9	1.2	2.1	2.2	1.5	-0.0
Allergy or Eczema	0.3	0.7	1.6	0.9	0.5	1.2	0.8	0.2
Relative age of first facial hair	0.3	0.6	1.4	-1.2	0.5	0.7	0.5	-0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.6	-1.3	0.1	-0.2	0.1	0.5
Supplements: Zinc	0.3	0.3	1.3	0.3	0.3	1.1	-0.4	0.4
Medication: Metformin	0.3	0.5	1.6	-1.2	-0.1	-0.2	-0.4	0.8
Relative age voice broke	0.3	0.4	0.7	0.4	0.8	0.8	0.7	-0.1
Age when periods started (menarche)	0.3	0.7	1.3	1.0	0.6	-0.1	1.0	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.4	0.6	0.3	-1.2	0.9	0.5
High blood pressure (mother)	0.3	0.5	1.1	0.0	0.1	-0.9	-0.6	-1.1
Qualifications: None of the above	0.3	0.6	1.3	1.1	0.7	0.4	1.0	-0.3
Medication: Ramipril	0.3	0.3	0.8	-0.2	-0.4	-0.9	-0.7	-0.5
Father’s age at death	0.3	0.4	1.0	0.2	-0.3	-0.8	-0.4	1.0
Happiness	0.3	0.4	1.1	0.6	-0.2	1.0	0.1	0.6
Lung cancer (father)	0.3	0.3	1.0	-0.6	-0.3	-0.4	-0.2	-1.0
Breastfed as a baby	0.3	0.4	1.5	-0.5	-0.1	-0.6	-0.0	1.2
Hair/balding pattern: Pattern 4	0.3	0.6	0.9	-1.0	-0.8	-0.0	-0.9	0.8
Gout (self-reported)	0.3	0.4	0.7	0.5	0.7	0.3	0.8	-0.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.0	1.0	0.8	0.9	0.5	-0.4
Number of children fathered	0.3	0.3	0.5	0.2	-0.7	0.3	-0.6	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	-0.3	-0.6	0.5	-0.6	0.8
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	0.5	-0.8	-0.2	-0.5	0.7
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	0.1	-0.4	0.8	-0.5	-0.9
Diabetes diagnosed by doctor	0.3	0.6	2.5	-0.6	0.1	-1.6	0.0	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.4	0.6	0.6	0.7	0.5	0.4
Illnesses of father: None of the above (group 1)	0.3	0.4	0.9	0.9	-0.2	-0.6	-0.4	0.6
Hearing aid user	0.3	0.3	0.9	0.6	0.1	0.9	-0.1	-0.5
Risk taking	0.3	0.4	0.9	0.3	-0.9	0.2	-0.3	1.0
Ever depressed for a whole week	0.3	0.4	0.9	-0.6	-0.9	0.2	-0.8	-0.2
Neuroticism (Nagel 2018)	0.2	0.6	1.5	0.4	1.2	0.3	0.9	-0.4
Schizophrenia (2018)	0.2	0.3	0.9	0.9	1.0	0.0	0.0	0.0
Alzheimer’s Disease (in father)	0.2	0.2	0.7	-0.3	-0.4	-0.8	-0.3	-0.2
Rheumatoid Arthritis	0.2	0.3	1.1	0.5	1.0	0.0	0.4	0.0
Triglycerides	0.2	0.4	0.7	0.8	0.5	0.2	0.8	0.6
Blood Red Count	0.2	1.8	5.8	-1.1	-0.5	-0.5	1.3	2.4
Chronotype (morning person)	0.2	0.5	1.4	-0.3	-0.1	1.2	-0.9	0.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.5	-0.7	-0.4	-0.1	-0.4	0.7
Angina	0.2	0.3	0.8	0.6	0.5	0.0	0.9	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.8	-0.2	0.2	-0.7	0.9	0.4
Waist circumference	0.2	0.6	1.4	-0.2	1.2	-0.6	1.1	0.2
Number of incorrect matches in round	0.2	0.3	0.8	0.9	0.7	-0.3	0.5	-0.1
Hearing difficulty/problems with background noise	0.2	0.4	1.1	0.0	-0.0	0.8	0.4	1.1
Mouth/teeth dental problems	0.2	0.3	0.9	0.1	0.4	-0.9	0.4	0.4
Fluid intelligence score	0.2	0.5	1.4	-1.2	-0.5	0.7	-0.6	0.1
Hip circumference	0.2	1.1	2.2	-1.5	-0.7	-1.2	-0.8	0.7
Time employed in main current job	0.2	0.3	0.7	0.2	0.5	0.4	0.8	0.6
Blood clot in the leg (DVT)	0.2	0.3	1.3	0.0	0.0	-0.5	0.2	1.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	-0.4	-0.2	-0.5	-0.2	0.8
Comparative body size at age 10	0.2	0.7	2.7	-0.6	-0.2	-1.6	0.4	-0.4
Angina (self-reported)	0.2	0.2	0.5	0.2	0.3	0.2	0.7	0.7
Suffer from ‘nerves’	0.2	0.3	0.6	-0.1	0.7	-0.3	0.7	0.5
Smoking status: Previous	0.2	0.3	0.5	-0.7	-0.4	-0.6	-0.7	-0.2
Ever had bowel cancer screening	0.2	0.2	0.7	-0.1	0.2	-0.9	0.3	-0.4
Friendships satisfaction	0.2	0.2	0.4	0.6	0.6	-0.1	0.3	-0.4
Qualifications: nursing, teaching	0.2	0.3	1.5	0.1	0.2	0.3	-0.1	-1.2
Commuting to job workplace: Walk	0.2	0.2	0.6	-0.5	-0.1	-0.1	0.1	0.8
Back pain experienced in last month	0.2	0.3	0.9	0.9	0.2	0.6	-0.1	-0.4
Guilty feelings	0.2	0.2	0.9	0.9	0.3	-0.1	-0.2	0.5
Mother’s age at death	0.2	0.3	0.7	-0.3	-0.8	-0.3	-0.6	0.4
High cholesterol (Self-reported)	0.2	0.4	0.9	-0.1	0.3	-1.0	0.7	0.5
Leg fat percentage (left)	0.2	0.8	1.8	0.4	1.4	0.1	1.4	0.1
Diastolic blood pressure, automated reading	0.2	0.5	1.5	-0.6	-0.3	-0.5	0.7	1.2
Myopia	0.2	0.2	0.5	-0.7	0.3	0.2	0.4	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	1.0	0.2	0.0	-0.2	0.3	1.0
Pack years of smoking	0.2	0.2	0.5	-0.2	0.6	-0.3	0.7	-0.5
Depression (Nagel 2018)	0.1	0.1	0.2	0.3	0.5	-0.1	0.1	-0.5
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	0.5	0.2	0.3	-0.3	-0.4
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	0.4	0.6	0.1	-0.1	-0.5
Major Depression (MDD)	0.1	0.1	0.3	0.0	0.5	0.2	0.5	-0.1
Bipolar Disorder (2011)	0.1	0.1	0.7	-0.8	0.0	0.0	0.0	0.0
HDL Cholesterol	0.1	0.2	1.0	0.2	-0.0	-0.3	0.1	-1.0
Ulcerative Colitis	0.1	0.2	0.9	0.9	0.4	0.0	0.0	0.0
Blood Eosinophil Count	0.1	0.4	1.3	-0.4	-0.6	0.5	-1.1	0.1
BMI	0.1	0.4	1.1	-0.6	0.3	-0.1	0.5	1.1
Diabetes (father)	0.1	0.2	0.3	0.6	0.1	0.5	-0.5	0.1
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.0	-0.0	0.4	0.5	0.1
Current tobacco smoking	0.1	0.2	0.4	-0.6	-0.6	-0.1	-0.6	0.3
Taking other prescription medications	0.1	0.2	0.6	-0.4	0.8	0.0	0.4	0.4
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.2	-0.1	-0.4	1.1	-0.4	0.0
Body mass index (BMI)	0.1	0.6	1.4	-0.0	0.9	-0.5	1.2	0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.9	0.0	-0.1	0.1	0.1	-0.9
Heart attack	0.1	0.1	0.1	0.3	0.4	-0.1	0.2	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.2	-0.2	-0.2	-0.6	-0.3
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.7	-0.7	-0.6	-0.5	0.3
Medication: Amlodipine	0.1	0.1	0.4	-0.3	0.5	-0.0	0.6	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.0	0.6	0.4	0.5	-0.2
Emphysema/chronic bronchitis	0.1	0.1	0.3	-0.4	-0.2	0.5	-0.5	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.4	-0.3	0.0	-0.6	0.5	-0.3
Leg fat mass (right)	0.1	0.2	0.4	-0.3	0.6	-0.6	0.5	0.3
Pulse rate, automated reading	0.1	0.4	1.2	0.0	0.3	-0.6	0.2	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.2	-0.5	-0.3	-0.3	-0.1
Miserableness	0.1	0.2	0.7	-0.1	0.1	-0.2	0.2	-0.8
Ever taken oral contraceptive pill	0.1	0.1	0.4	-0.3	-0.5	-0.1	-0.6	-0.3
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.0	0.4	-0.2	0.4	-0.2
Average weekly beer plus cider intake	0.1	0.1	0.2	0.3	0.0	0.2	0.4	0.4
Irritability	0.1	0.1	0.3	0.5	0.5	0.2	0.2	-0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.4	0.5	-0.1	0.3	-0.4
Leg fat mass (left)	0.1	0.3	0.7	-0.6	0.2	-0.9	0.0	0.4
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	-0.2	-0.6	0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.1	0.2	0.3	0.0	0.0	0.0
Worry (Nagel 2018)	0.0	0.0	0.1	0.1	0.2	-0.0	-0.1	0.3
Mean Putamen Volume	0.0	0.0	0.1	-0.3	0.1	0.0	0.2	0.0
Schizophrenia (2014)	0.0	0.0	0.2	0.5	-0.0	0.0	0.0	0.0
Neuroticism	0.0	0.1	0.3	0.1	0.5	-0.2	-0.1	0.5
Hair Pigment	0.0	1.0	4.0	2.0	0.9	0.2	0.2	-0.1
Tanning	0.0	0.4	1.7	-0.3	-0.0	-0.3	-0.3	1.3
Pack years adult smoking proportion	0.0	0.0	0.1	-0.3	0.1	-0.2	0.2	-0.0
Medication: Atenolol	0.0	0.1	0.1	-0.4	-0.0	-0.3	0.2	-0.0
Trunk fat mass	0.0	0.1	0.2	-0.4	0.4	-0.1	0.3	0.5
Arm fat mass (right)	0.0	0.2	0.3	-0.5	0.5	-0.1	0.4	0.5
Whole body fat mass	0.0	0.2	0.3	-0.3	0.5	-0.3	0.4	0.5
Arm fat mass (left)	0.0	0.2	0.2	-0.5	0.5	-0.4	0.3	0.4
Average weekly champagne plus white wine intake	0.0	0.0	0.2	0.0	0.2	-0.1	-0.4	-0.2
Illnesses of father: High blood pressure	0.0	0.0	0.1	-0.2	-0.1	-0.2	0.2	-0.0

Hub : Genes

SFTPA2

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Trait associations