Best TWAS P=3.14e-14 · Best GWAS P=1.11e-14 conditioned to 0.376
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SLC9A3R2 | 0.15 | 0.09 | enet | 7 | 0.10 | 7.8e-12 | -6.0 | 5.8 | 5.2e-09 | -0.68 | 0.94 | 0.06 | FALSE |
| 2 | GTEx | Artery Aorta | TSC2 | 0.08 | 0.02 | enet | 7 | 0.03 | 5.0e-03 | -5.5 | 6.5 | 1.0e-10 | -0.43 | 0.13 | 0.36 | FALSE |
| 3 | METSIM | Adipose | PKD1 | 0.06 | 0.02 | bslmm | 370 | 0.03 | 9.5e-06 | -7.7 | 7.0 | 2.0e-12 | -0.73 | 0.01 | 0.99 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | SLC9A3R2 | 0.16 | 0.11 | lasso | 6 | 0.12 | 6.3e-15 | -6.7 | 7.6 | 3.1e-14 | -0.76 | 0.46 | 0.54 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | TSC2 | 0.28 | 0.17 | bslmm | 372 | 0.17 | 2.1e-21 | -6.4 | 5.8 | 7.4e-09 | -0.52 | 0.93 | 0.07 | FALSE |
| 6 | YFS | Blood | TSC2 | 0.03 | 0.02 | lasso | 4 | 0.02 | 7.6e-08 | -7.2 | 7.2 | 5.5e-13 | -0.55 | 0.16 | 0.84 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TSC2 | 0.02 | 0.03 | lasso | 1 | 0.02 | 1.8e-05 | -7.2 | 7.2 | 5.7e-13 | -0.48 | 0.09 | 0.76 | TRUE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CASKIN1 | 0.02 | 0.00 | blup | 38 | 0.01 | 4.5e-02 | 3.3 | -5.3 | 1.1e-07 | 0.31 | 0.03 | 0.04 | TRUE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | CASKIN1 | 0.06 | 0.02 | blup | 38 | 0.04 | 1.5e-04 | -6.7 | -6.0 | 1.8e-09 | 0.61 | 0.00 | 0.97 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC9A3R2 | 0.06 | 0.03 | lasso | 5 | 0.03 | 3.7e-04 | -6.0 | 7.5 | 5.0e-14 | -0.72 | 0.07 | 0.73 | FALSE |