TWAS hub - PKD1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.3650	0.1220	0.0035	0.01	NA	-0.010	NA	0.024	0.16000	NA	9.0e-01	NA	6.7e-02
2	METSIM	Adipose	0.0559	0.0215	0.0004	0.02	0.031	0.031	0.033	0.025	0.00047	1.8e-05	1.8e-05	9.5e-06	9.7e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hand grip strength (left)	9.7	25.5	50.2	-1.0	7.1
Hand grip strength (right)	9.4	25.5	49.5	-1.2	7.0
Health satisfaction	7.5	9.7	11.1	-2.9	-3.3
Comparative height size at age 10	7.1	38.8	69.6	2.9	8.3
Heel T-Score	5.6	44.8	84.5	-2.3	-9.2
Sitting height	5.6	40.1	80.1	0.0	8.9
Number of children fathered	5.6	6.3	9.6	-3.1	-1.8
Birth weight	5.0	10.9	11.7	3.4	3.2
Arm fat-free mass (left)	5.0	25.5	49.4	1.2	7.0
Arm predicted mass (left)	5.0	25.2	48.6	1.4	7.0
Weight	4.9	23.9	42.1	2.4	6.5
Basal metabolic rate	4.9	26.9	48.4	2.3	7.0
Waist circumference	4.8	17.4	29.8	2.2	5.5
Arm predicted mass (right)	4.8	24.5	48.0	1.0	6.9
Standing height	4.7	47.1	85.6	2.9	9.2
Arm fat-free mass (right)	4.7	24.2	46.4	1.4	6.8
Trunk fat mass	4.5	19.3	35.2	1.9	5.9
Trunk fat-free mass	4.5	26.1	47.1	2.3	6.9
Whole body water mass	4.5	25.7	46.6	2.2	6.8
LDL Cholesterol	4.4	6.9	12.9	3.6	1.0
Trunk predicted mass	4.4	25.2	45.2	2.3	6.7
Whole body fat mass	4.4	18.4	33.1	1.9	5.8
Whole body fat-free mass	4.4	25.4	46.1	2.2	6.8
Pack years of smoking	4.0	5.8	11.3	0.6	3.4
Height	3.9	75.5	139.2	3.4	11.8
Leg fat-free mass (left)	3.9	20.8	35.9	2.4	6.0
Leg predicted mass (left)	3.9	20.8	36.2	2.3	6.0
Migraine (self-reported)	3.8	4.7	9.2	-3.0	-0.4
Family relationship satisfaction	3.8	4.6	8.0	-1.1	-2.8
Knee pain experienced in last month	3.7	5.8	11.3	3.4	-0.5
Leg fat mass (left)	3.7	14.3	26.2	1.5	5.1
Leg fat-free mass (right)	3.6	19.3	33.9	2.2	5.8
Blood clot in the leg (DVT)	3.5	4.5	4.5	2.1	-2.1
Leg fat mass (right)	3.5	13.7	24.8	1.6	5.0
Leg predicted mass (right)	3.5	18.7	32.8	2.1	5.7
Peak expiratory flow (PEF)	3.4	8.0	15.9	-0.0	4.0
Deep venous thrombosis (DVT) (self-reported)	3.4	4.3	4.4	2.1	-2.1
Waist Hip Ratio (WHR)	3.2	14.4	26.1	1.6	5.1
Pack years adult smoking proportion	3.2	4.8	9.4	0.6	3.1
Heel bone mineral density (BMD) T-score, automated (right)	3.2	7.3	10.9	-1.9	-3.3
Serious illness, injury or assault to yourself	3.1	3.7	4.5	1.7	2.1
Allergy	3.1	7.1	7.2	-2.6	2.7
Trunk fat percentage	3.0	12.1	22.6	1.3	4.8
Qualifications: CSEs or equivalent	3.0	4.0	7.7	-0.5	2.8
Arm fat mass (right)	3.0	12.3	19.4	2.3	4.4
Arm fat mass (left)	3.0	12.2	20.1	2.1	4.5
Loud music exposure frequency	2.8	3.1	4.2	-1.4	2.1
Body fat percentage	2.8	10.9	20.0	1.3	4.5
Falls in the last year	2.7	3.6	4.9	2.2	1.6
Heel bone mineral density (BMD) T-score, automated (left)	2.6	5.8	7.9	-1.9	-2.8
Worrier / anxious feelings	2.5	4.7	7.0	-1.5	-2.6
Gout (self-reported)	2.5	3.4	6.5	-0.5	-2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	4.4	2.1	-1.2
Blood White Count	2.4	18.0	35.2	0.9	5.9
Hayfever, allergic rhinitis or eczema	2.4	5.2	8.8	1.3	-3.0
Hip circumference	2.4	10.4	19.2	1.3	4.4
Shortness of breath walking on level ground	2.4	2.8	5.1	-2.2	-0.8
Qualifications: nursing, teaching	2.4	3.7	6.3	-1.1	-2.5
Fed-up feelings	2.3	4.2	8.5	0.1	2.9
Ever depressed for a whole week	2.3	2.8	5.6	-2.4	0.2
Systolic Blood Pressure	2.2	11.0	19.3	-4.4	1.6
Chronic bronchitis/emphysema (father)	2.2	2.6	4.9	-0.5	-2.2
Forced vital capacity (FVC)	2.2	8.4	16.7	0.4	4.1
Worry too long after embarrassment	2.2	3.7	4.4	-1.7	-2.1
Average weekly fortified wine intake	2.1	2.5	3.0	1.7	-1.4
Medication: Levothyroxine sodium	2.1	3.6	7.2	2.7	-0.2
High blood pressure (siblings)	2.1	3.0	6.0	-0.1	-2.4
Respiratory disease	2.0	4.4	8.6	2.9	-0.5
Asthma	2.0	3.9	7.7	2.8	-0.2
Forced vital capacity (FVC), Best measure	2.0	7.5	14.8	0.4	3.8
Commuting to job workplace: Public transport	2.0	2.4	3.9	2.0	-1.0
Systolic blood pressure, automated reading	1.9	5.4	8.7	-2.9	1.5
Forced expiratory volume in 1-second (FEV1)	1.9	6.4	12.6	0.4	3.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.0	11.6	0.7	3.4
Pulse wave Arterial Stiffness index	1.9	2.2	3.3	1.1	1.8
Leg fat percentage (right)	1.9	6.9	13.2	0.8	3.6
Forced expiratory volume in 1-second (FEV1), predicted	1.9	4.0	7.5	0.6	2.7
Back pain experienced in last month	1.9	2.8	5.5	0.1	-2.4
Asthma (self-reported)	1.9	3.8	7.5	2.7	-0.4
Leg fat percentage (left)	1.9	6.9	13.5	0.4	3.7
Crohns Disease (2012)	1.8	2.8	3.1	-1.6	1.8
Noisy workplace	1.8	2.2	4.3	-2.1	0.1
Mouth/teeth dental problems: Dentures	1.8	3.0	3.7	1.9	1.5
Medication for pain relief, constipation, heartburn	1.8	3.0	3.9	-1.4	2.0
Alcohol intake frequency.	1.8	4.2	6.8	-1.2	2.6
Triglycerides	1.7	2.8	3.7	1.9	-1.4
Stomach or abdominal pain in last month	1.7	2.1	2.6	-1.3	-1.6
Medication: Blood pressure	1.7	3.0	5.9	-2.4	0.3
Medication: Omeprazole	1.7	2.0	2.7	1.1	-1.6
Average weekly champagne plus white wine intake	1.7	2.3	4.2	2.1	-0.7
Financial situation satisfaction	1.7	2.1	3.1	-1.1	-1.8
Pain experienced in last month	1.7	2.9	5.5	0.5	2.3
Depressed Affect (Nagel 2018)	1.6	3.3	6.6	0.3	2.6
Medication: Ventolin 100micrograms inhaler	1.6	2.1	3.4	1.8	0.9
Bipolar Disorder (2018)	1.5	2.3	4.3	-2.1	-0.6
Average weekly spirits intake	1.5	1.8	3.6	1.9	0.3
Vitamin and mineral supplements	1.5	2.0	4.0	-2.0	0.3
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.7	-0.3	-1.9
Hypothyroidism/myxoedema (self-reported)	1.5	3.0	4.9	2.2	-1.0
Exposure to tobacco smoke outside home	1.5	2.0	3.6	-0.7	1.9
Age at last live birth	1.5	2.1	4.1	-0.3	-2.0
Eye problems/disorders: Cataract	1.5	1.7	2.9	-0.7	-1.7
Osteoarthritis (self-reported)	1.5	2.0	3.8	2.0	0.2
Mean Putamen Volume	1.4	1.7	3.1	-1.8	0.5
Allergy or Eczema	1.4	3.6	6.1	1.1	-2.5
Hypothyroidism (self reported)	1.4	3.3	5.0	2.2	-1.3
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	3.1	1.8	0.2
Breastfed as a baby	1.4	1.7	3.5	-0.0	-1.9
Emphysema/chronic bronchitis	1.4	1.5	2.1	1.0	-1.4
Number of full sisters	1.4	1.8	3.4	0.3	1.9
Leg pain on walking	1.4	1.8	3.0	-0.8	-1.7
Number of self-reported non-cancer illnesses	1.4	2.5	3.2	1.8	-1.3
Irritability	1.4	2.3	2.6	1.4	1.6
Bipolar Disorder or Schizophrenia	1.3	3.1	5.3	-2.3	-1.0
Schizophrenia (2014)	1.3	2.9	5.9	-2.4	-0.1
Chronotype (morning person)	1.3	2.9	3.4	-1.6	-1.8
Diabetes (father)	1.3	1.6	2.3	-1.0	1.5
Taking other prescription medications	1.3	2.0	2.2	1.5	-1.3
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.7	-0.1	-1.6
Pain all over the body in last month	1.3	1.4	2.9	-0.2	1.7
Arm fat percentage (right)	1.3	5.3	6.8	1.9	2.6
Exposure to tobacco smoke at home	1.3	1.5	1.5	1.2	1.2
Birth weight of first child	1.3	2.4	3.4	1.2	1.8
Age at first live birth	1.3	2.4	2.8	-1.4	-1.7
Friendships satisfaction	1.3	1.6	2.1	-1.0	-1.5
Hearing aid user	1.3	1.5	1.8	1.1	1.3
Eye problems/disorders: Glaucoma	1.3	1.5	3.1	-0.1	-1.7
High cholesterol (Self-reported)	1.3	2.3	3.0	1.7	-1.3
Medication: Omeprazole (e.g. Zanprol)	1.3	1.5	2.0	1.4	-1.1
Coronary Artery Disease (CAD)	1.2	1.5	2.9	0.0	-1.7
Relative age of first facial hair	1.2	2.5	4.0	2.0	-1.0
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	1.6	-1.1	-1.2
Supplements: Glucosamine	1.2	1.5	2.5	1.6	-0.8
Medication: Simvastatin	1.2	1.7	3.4	1.9	-0.0
Lung cancer (father)	1.2	1.4	2.3	-0.6	-1.5
Glaucoma (self-reported)	1.2	1.4	2.5	0.6	-1.6
Arm fat percentage (left)	1.2	4.8	6.6	1.8	2.6
Breast Cancer	1.1	2.7	3.5	-1.4	1.9
BMI	1.1	6.3	10.0	1.6	3.2
Ever had hysterectomy (womb removed)	1.1	1.2	1.4	1.0	1.2
Number of incorrect matches in round	1.1	1.8	2.1	1.4	-1.2
Nervous feelings	1.1	2.1	3.7	-1.9	-0.7
Qualifications: None of the above	1.1	2.4	4.8	0.0	2.2
Happiness	1.1	1.4	2.5	-0.5	-1.6
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	1.5	-1.0	-1.2
Depression (self-reported)	1.1	1.4	1.8	-1.4	-0.9
Pulse wave peak to peak time	1.1	1.3	2.0	-0.8	-1.4
Wears glasses or contact lenses	1.1	1.3	1.5	1.0	-1.2
Ever had prostate specific antigen (PSA) test	1.1	1.2	1.4	1.1	-1.2
Worry (Nagel 2018)	1.0	2.0	2.5	-1.6	-1.2
Ulcerative Colitis	1.0	1.4	2.4	-1.5	-0.6
Body mass index (BMI)	1.0	4.3	7.1	1.2	2.7
Alcohol intake versus 10 years previously	1.0	1.6	2.9	0.5	1.7
Commuting to job workplace: Cycle	1.0	1.2	2.3	-0.4	-1.5
Neuroticism (2016)	0.9	1.3	2.3	-1.5	0.6
Rheumatoid Arthritis	0.9	1.2	2.4	0.2	-1.5
Maternal smoking around birth	0.9	1.3	2.5	1.6	0.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.6	-0.7	1.3
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	2.1	0.4	-1.4
Headache pain in last month	0.9	1.6	2.1	-1.0	-1.4
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.1	1.4	0.1
Alzheimer’s Disease (in mother)	0.8	0.9	1.7	-0.2	-1.3
Alzheimer’s Disease (including proxy)	0.8	1.1	2.2	-0.1	-1.5
Ulcerative Colitis (UC)	0.8	1.6	3.1	-1.8	-0.3
Age at First Birth	0.8	1.2	1.5	-1.2	-0.9
Fasting Glucose	0.8	0.9	1.8	0.3	1.3
Number of treatments/medications taken	0.8	1.5	2.4	0.8	-1.6
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.2	-1.5	-0.0
Age when periods started (menarche)	0.8	1.9	3.5	-1.9	-0.6
Multivitamins +/- minerals	0.8	1.0	1.2	1.1	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.3	-1.5	0.1
Medication: Amlodipine	0.8	1.1	2.2	1.5	0.1
Medication: Allopurinol	0.8	1.0	2.0	-0.2	-1.4
Ever had bowel cancer screening	0.8	1.0	1.8	-0.3	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.8	-0.0	1.3
Mother’s age at death	0.8	1.0	1.7	-0.6	-1.3
Depression (Nagel 2018)	0.7	1.1	2.1	-1.4	0.3
Ovarian Cancer	0.7	0.9	1.6	1.3	-0.5
HbA1C	0.7	0.8	1.5	-0.3	-1.2
Lung FEV1/FVC ratio	0.7	3.6	5.6	2.4	1.3
Current tobacco smoking	0.7	1.2	2.2	0.4	1.5
Relative age voice broke	0.7	1.0	2.0	0.2	-1.4
Alcohol usually taken with meals	0.7	1.2	1.8	0.8	1.3
Illnesses of siblings	0.7	1.0	1.3	0.9	1.1
Tense / ‘highly strung’	0.7	1.1	1.6	-0.8	-1.3
Medication: Paracetamol	0.7	1.2	1.3	1.1	-1.0
Supplements: Vitamin C	0.7	0.9	1.7	1.3	-0.2
Mood swings	0.7	1.2	2.2	0.5	1.5
Breast cancer (self-reported)	0.7	0.9	1.7	1.3	-0.1
Smoking status: Current	0.7	1.1	2.0	0.5	1.4
Fractured/broken bones in last 5 years	0.7	0.9	0.9	0.9	0.9
Diastolic blood pressure, automated reading	0.7	2.1	2.3	-1.4	1.5
Alzheimer’s Disease (in father)	0.6	0.6	1.1	1.1	0.2
Smoking Status	0.6	1.4	1.5	1.2	1.1
Type 2 Diabetes (T2D) (2018)	0.6	1.0	1.8	-1.3	0.6
High blood pressure	0.6	1.6	2.1	-1.5	-1.1
Hair/balding pattern: Pattern 3	0.6	1.0	1.3	-1.1	-0.8
Pulse rate	0.6	1.1	2.2	1.5	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	0.1	-1.2
Suffer from ‘nerves’	0.6	1.0	1.4	-1.2	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.5	1.2	-0.1
Miserableness	0.6	1.1	1.4	-0.8	1.2
Medication: Atorvastatin	0.6	0.7	1.4	-1.2	0.2
Illnesses of father: High blood pressure	0.6	0.7	1.3	-0.3	-1.1
Number of operations (self-reported)	0.6	0.8	1.4	1.2	-0.5
Schizophrenia (2018)	0.5	1.1	1.9	-1.4	-0.6
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.2	0.2	1.5
Cardiovascular Disease	0.5	1.5	2.6	-1.6	-0.7
Diabetes (mother)	0.5	0.6	1.2	1.1	0.1
Had menopause	0.5	0.6	1.1	-1.1	0.3
Financial difficulties in last 2 years	0.5	0.7	0.9	0.7	-0.9
Number of live births	0.5	0.7	0.8	0.8	-0.9
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.9	-0.5	-1.4
Prospective memory result	0.5	0.7	1.0	0.6	-1.0
Wheeze or whistling in the chest in last year	0.5	1.0	1.1	1.0	0.9
Qualifications: College or University degree	0.5	1.5	2.6	0.6	-1.6
Heart disease (mother)	0.5	0.6	1.0	-0.3	1.0
Chest pain or discomfort	0.5	0.8	1.4	-0.4	1.2
Medication: Aspirin	0.5	0.6	1.1	-0.3	-1.1
Hypertension (Self-reported)	0.5	1.3	1.3	-1.1	-1.1
Ever taken oral contraceptive pill	0.5	0.5	0.7	-0.8	0.6
Alcohol drinker status: Never	0.5	0.6	1.0	-0.3	1.0
Risk taking	0.5	0.7	1.4	1.2	-0.1
Cholesterol lowering medication	0.5	0.7	1.1	1.1	-0.5
Crohns Disease (2017)	0.4	0.8	1.2	-1.1	0.6
Irritable Bowel Disease (IBD)	0.4	1.0	1.8	-1.4	0.5
HDL Cholesterol	0.4	0.6	1.1	-1.1	-0.3
Sensitivity / hurt feelings	0.4	0.6	0.9	0.6	-1.0
Hearing difficulty/problems: Yes	0.4	0.7	0.7	0.9	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.0	-0.4	1.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.9	-0.9	-0.0
High blood pressure (mother)	0.4	0.6	0.9	-0.5	-1.0
Impedance of leg (left)	0.4	2.0	3.4	-1.9	0.7
Hearing difficulty/problems with background noise	0.4	0.7	1.4	-0.0	-1.2
Mouth/teeth dental problems	0.4	0.6	1.2	-1.1	-0.3
Heart attack	0.4	0.5	0.9	0.0	-1.0
Diabetes (self-reported)	0.4	0.6	1.0	-0.5	-1.0
Impedance of arm (right)	0.4	1.9	3.2	0.8	-1.8
Length of working week for main job	0.4	0.5	0.9	1.0	-0.2
Medication: Ibuprofen	0.4	0.5	1.0	0.1	-1.0
Medication: Seretide 50 evohaler	0.4	0.4	0.5	0.6	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.7	0.5	0.9
Pulse rate, automated reading	0.4	1.2	2.3	1.5	-0.3
Had major operations	0.4	0.5	0.7	0.8	-0.5
Medication: Lisinopril	0.4	0.6	1.0	-1.0	-0.3
Supplements: Calcium	0.4	0.4	0.5	-0.7	0.6
Basal cell carcinoma (self-reported)	0.4	0.4	0.8	0.1	0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.9	0.2	-1.0
Lupus	0.3	0.4	0.5	0.5	0.7
Blood Eosinophil Count	0.3	2.0	3.8	1.9	-0.4
Blood Red Count	0.3	3.0	3.2	-1.8	1.6
Neuroticism	0.3	0.7	0.7	-0.8	0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	-0.0	-0.9
Supplements: Zinc	0.3	0.3	0.5	-0.2	0.7
Hair/balding pattern: Pattern 2	0.3	0.4	0.8	0.2	0.9
Had other major operations	0.3	0.4	0.7	0.8	-0.3
Time employed in main current job	0.3	0.4	0.4	-0.7	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.1	1.0	0.0
Impedance of arm (left)	0.3	1.4	2.7	0.4	-1.6
Hair/balding pattern: Pattern 4	0.3	0.8	1.4	-1.2	-0.3
Number of full brothers	0.3	0.4	0.7	0.9	-0.0
Eye problems/disorders: None of the above	0.3	0.4	0.5	0.7	0.5
Mean time to correctly identify matches	0.3	0.5	0.5	0.7	-0.7
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	-0.1	-0.8
Average weekly red wine intake	0.3	0.4	0.7	0.3	0.8
Long-standing illness, disability or infirmity	0.3	0.5	0.8	0.9	-0.3
Medication for cholesterol	0.3	0.4	0.5	-0.7	0.6
Osteoporosis (self-reported)	0.3	0.4	0.8	-0.0	-0.9
Guilty feelings	0.3	0.5	0.8	-0.9	-0.5
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.7	-0.0	0.9
Medication: Blood pressure	0.3	0.5	0.9	0.3	-0.9
Medication: Bendroflumethiazide	0.3	0.5	0.9	-1.0	-0.0
Neuroticism (Nagel 2018)	0.2	0.5	0.7	-0.8	0.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.7	0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.5	0.0	0.7
Blood Platelet Count	0.2	2.5	5.1	2.2	0.2
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.5	-0.1	0.7
Medication for hormone replacement therapy	0.2	0.3	0.5	0.3	-0.7
Impedance of leg (right)	0.2	1.0	1.6	-1.2	0.6
Townsend deprivation index at recruitment	0.2	0.3	0.4	-0.4	-0.6
Medication: Atenolol	0.2	0.2	0.3	0.3	0.6
Neuroticism score	0.2	0.4	0.7	-0.8	-0.3
Medication: Cholesterol lowering	0.2	0.3	0.5	0.7	0.0
Medication: Lansoprazole	0.2	0.2	0.4	0.0	-0.6
Pulse wave reflection index	0.2	0.3	0.5	0.1	0.7
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.3	-0.6	0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	0.7	-0.4
Comparative body size at age 10	0.2	0.6	1.0	0.5	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	0.7	-0.4
Neck or shoulder pain in last month	0.2	0.3	0.5	0.2	-0.7
Illnesses of father: Heart disease	0.2	0.3	0.5	0.3	0.7
Smoking status: Previous	0.2	0.2	0.4	0.2	0.7
Loneliness, isolation	0.2	0.3	0.5	-0.0	-0.7
Commuting to job workplace: Walk	0.2	0.3	0.3	0.6	-0.4
Medication: Paracetamol	0.2	0.3	0.5	0.7	-0.0
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.2	1.1	0.1
Prostate Cancer	0.1	0.1	0.2	0.4	-0.0
Primary Biliary Cirrhosis	0.1	0.2	0.3	0.2	0.5
Hair Pigment	0.1	3.6	5.8	2.4	-1.2
Tanning	0.1	1.2	2.0	-1.4	0.6
Medication: Metformin	0.1	0.1	0.2	0.4	-0.2
Severe depression (siblings)	0.1	0.1	0.1	-0.2	-0.3
Past tobacco smoking	0.1	0.2	0.3	-0.3	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	0.0	-0.5
Father’s age at death	0.1	0.2	0.3	-0.2	-0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	-0.3	-0.6
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.1	-0.3	0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	-0.3	0.3
Overall health rating	0.1	0.3	0.3	-0.5	-0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.1	0.3	-0.3
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.4	-0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.4	0.2
Diabetes diagnosed by doctor	0.1	0.1	0.1	-0.3	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.1	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	0.6	-0.2
Mineral and other dietary supplements	0.1	0.1	0.1	-0.4	0.2
Medication: Aspirin	0.1	0.2	0.3	0.1	-0.6
Medication: Gliclazide	0.1	0.1	0.2	-0.1	0.5
Illnesses of father: None of the above (group 1)	0.1	0.1	0.1	0.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	-0.1	-0.7
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.3	-0.2	0.6
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	0.1	-0.4
Average weekly beer plus cider intake	0.1	0.1	0.2	-0.0	0.5
Heart disease (siblings)	0.1	0.1	0.1	-0.4	0.2
Alcohol drinker status: Previous	0.1	0.1	0.1	-0.0	0.4
Impedance of whole body	0.1	0.8	1.2	-1.1	-0.6
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	-0.4	-0.2
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	-0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.0	0.0	0.0	0.2	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Lung FVC	0.0	0.1	0.2	-0.4	0.1
Angina	0.0	0.1	0.1	-0.2	0.3
Medication: Co-codamol	0.0	0.1	0.1	0.1	0.3
Medication: Ramipril	0.0	0.0	0.0	-0.1	-0.1
Fluid intelligence score	0.0	0.0	0.0	-0.2	0.1
Illnesses of mother	0.0	0.1	0.1	0.2	0.3
Angina (self-reported)	0.0	0.0	0.0	-0.1	0.2
Ever smoked	0.0	0.0	0.1	-0.3	0.1
Age started oral contraceptive pill	0.0	0.0	0.0	-0.0	-0.0
Unable to work because of sickness or disability	0.0	0.0	0.0	0.2	-0.1
Myopia	0.0	0.0	0.1	-0.3	-0.1

Hub : Genes

PKD1

Models

Trait associations