Best TWAS P=1.52e-14 · Best GWAS P=4.25e-18 conditioned to 0.173
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | KIAA1683 | 0.09 | 0.06 | enet | 14 | 0.10 | 6.6e-12 | -3.49 | 6.0 | 1.7e-09 | 0.60 | 0.68 | 0.32 | FALSE |
2 | GTEx | Adipose Subcutaneous | AC005253.4 | 0.11 | 0.06 | enet | 23 | 0.04 | 1.6e-04 | -0.48 | 5.6 | 1.8e-08 | 0.46 | 0.24 | 0.38 | FALSE |
3 | GTEx | Colon Transverse | SSBP4 | 0.18 | 0.01 | enet | 21 | 0.00 | 3.6e-01 | 5.12 | -5.5 | 4.0e-08 | -0.57 | 0.06 | 0.25 | FALSE |
4 | GTEx | Colon Transverse | KIAA1683 | 0.15 | 0.02 | lasso | 3 | 0.02 | 3.3e-02 | -4.04 | 6.5 | 8.7e-11 | 0.55 | 0.28 | 0.28 | FALSE |
5 | GTEx | Nerve Tibial | KIAA1683 | 0.25 | 0.22 | lasso | 9 | 0.28 | 5.2e-20 | 7.68 | 6.0 | 1.4e-09 | 0.52 | 0.80 | 0.20 | FALSE |
6 | GTEx | Pancreas | AC007192.6 | 0.19 | 0.00 | enet | 28 | 0.01 | 1.3e-01 | 7.77 | -5.6 | 2.4e-08 | -0.55 | 0.03 | 0.62 | FALSE |
7 | GTEx | Testis | PDE4C | 0.39 | 0.44 | lasso | 2 | 0.43 | 5.8e-21 | -5.43 | -5.4 | 5.7e-08 | -0.39 | 1.00 | 0.00 | FALSE |
8 | GTEx | Testis | AC068499.10 | 0.38 | 0.41 | lasso | 3 | 0.40 | 6.8e-19 | -5.43 | -5.5 | 3.3e-08 | -0.40 | 1.00 | 0.00 | FALSE |
9 | GTEx | Thyroid | KIAA1683 | 0.11 | 0.07 | enet | 14 | 0.12 | 2.1e-09 | 5.16 | 7.5 | 5.4e-14 | 0.62 | 0.74 | 0.24 | FALSE |
10 | GTEx | Vagina | LRRC25 | 0.63 | 0.02 | enet | 2 | 0.04 | 5.3e-02 | 7.68 | -7.7 | 1.5e-14 | -0.54 | 0.04 | 0.19 | TRUE |
11 | METSIM | Adipose | CILP2 | 0.04 | 0.03 | lasso | 5 | 0.07 | 2.7e-11 | -3.17 | -5.4 | 6.9e-08 | -0.11 | 0.14 | 0.78 | TRUE |
12 | NTR | Blood | IFI30 | 0.03 | 0.02 | lasso | 6 | 0.02 | 8.8e-08 | 7.54 | 6.2 | 4.3e-10 | 0.82 | 0.08 | 0.92 | FALSE |
13 | ROSMAP | Brain Pre-frontal Cortex | PDE4C | 0.18 | 0.12 | enet | 17 | 0.19 | 3.3e-24 | -2.81 | -5.9 | 4.2e-09 | -0.75 | 0.58 | 0.42 | FALSE |
14 | ROSMAP | Brain Pre-frontal Cortex | KIAA1683 | 0.23 | 0.14 | bslmm | 409 | 0.24 | 1.4e-30 | -1.90 | 5.3 | 1.0e-07 | 0.47 | 0.95 | 0.05 | FALSE |
15 | ROSMAP | Brain Pre-frontal Cortex | JUND | 0.17 | 0.17 | lasso | 5 | 0.20 | 2.7e-25 | 7.68 | 6.8 | 7.4e-12 | 0.55 | 0.78 | 0.22 | FALSE |
16 | YFS | Blood | KIAA1683 | 0.51 | 0.40 | enet | 65 | 0.46 | 9.9e-171 | 7.67 | 5.7 | 1.4e-08 | 0.46 | 0.80 | 0.20 | FALSE |
17 | YFS | Blood | MAST3 | 0.06 | 0.04 | lasso | 5 | 0.04 | 4.2e-12 | 7.77 | -7.5 | 8.9e-14 | -0.71 | 0.46 | 0.54 | FALSE |
18 | The Cancer Genome Atlas | Glioblastoma Multiforme | JUND | 0.17 | 0.00 | blup | 57 | 0.03 | 5.4e-02 | 7.68 | 7.3 | 4.0e-13 | 0.57 | 0.01 | 0.59 | FALSE |
19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | JUND | 0.05 | 0.04 | lasso | 1 | 0.04 | 4.3e-05 | 7.68 | 7.7 | 1.5e-14 | 0.54 | 0.10 | 0.39 | FALSE |
20 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MAST3 | 0.04 | 0.02 | blup | 65 | 0.01 | 7.3e-02 | 7.77 | -6.1 | 1.0e-09 | -0.60 | 0.01 | 0.49 | FALSE |
21 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | JUND | 0.11 | 0.03 | blup | 58 | 0.04 | 1.4e-03 | -2.74 | 6.5 | 9.2e-11 | 0.37 | 0.04 | 0.08 | FALSE |
22 | The Cancer Genome Atlas | Brain Lower Grade Glioma | JUND | 0.04 | 0.03 | lasso | 2 | 0.02 | 7.9e-04 | 7.68 | 7.6 | 3.1e-14 | 0.54 | 0.13 | 0.34 | FALSE |
23 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MAST3 | 0.02 | 0.02 | lasso | 3 | 0.01 | 1.5e-02 | 7.36 | -7.5 | 8.5e-14 | -0.48 | 0.06 | 0.57 | FALSE |
24 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IL12RB1 | 0.07 | 0.04 | blup | 58 | 0.06 | 4.9e-07 | 4.38 | -5.8 | 6.6e-09 | -0.45 | 0.87 | 0.11 | FALSE |
25 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | KIAA1683 | 0.09 | 0.05 | lasso | 4 | 0.06 | 1.3e-07 | 7.68 | 5.6 | 1.7e-08 | 0.46 | 0.78 | 0.15 | FALSE |
26 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | IL12RB1 | 0.10 | 0.01 | enet | 10 | 0.06 | 2.6e-03 | 1.97 | -6.3 | 2.5e-10 | -0.46 | 0.01 | 0.68 | TRUE |
27 | The Cancer Genome Atlas | Thyroid Carcinoma | IL12RB1 | 0.08 | 0.04 | lasso | 3 | 0.05 | 8.9e-06 | 4.03 | -5.2 | 1.8e-07 | -0.45 | 0.30 | 0.52 | FALSE |
28 | The Cancer Genome Atlas | Thyroid Carcinoma | MAST3 | 0.04 | 0.02 | lasso | 2 | 0.00 | 3.4e-01 | 7.36 | -7.4 | 1.5e-13 | -0.48 | 0.07 | 0.40 | FALSE |