TWAS hub - CILP2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0430	0.0188	2.6e-05	0.027	0.041	0.069	0.057	0.075	0.00005	8.3e-07	1.4e-10	6.2e-09	2.7e-11
2	TCGA	Breast Invasive Carcinoma	0.0181	0.0122	9.1e-04	0.017	0.017	0.010	NA	0.016	0.00014	1.6e-04	2.7e-03	NA	2.5e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Myopia	12.7	18.4	18.8	4.2	4.3
Townsend deprivation index at recruitment	11.7	16.5	17.6	-4.2	-3.9
Bipolar Disorder (2018)	11.5	18.3	27.0	3.1	5.2
Mouth/teeth dental problems: Bleeding gums	11.3	14.6	18.0	-3.4	-4.2
Bipolar Disorder or Schizophrenia	10.1	24.6	31.2	4.2	5.6
Hearing difficulty/problems: Yes	9.8	14.9	19.7	-3.2	-4.4
Rheumatoid Arthritis	8.9	12.3	16.1	2.9	4.0
Medication: Cholesterol lowering	8.7	13.5	15.3	-3.9	-3.4
Impedance of arm (right)	8.6	39.9	57.5	4.7	7.6
Impedance of whole body	8.4	42.6	56.2	5.4	7.5
BMI	8.0	46.6	48.3	-6.7	-7.0
Impedance of arm (left)	7.7	35.8	54.1	4.2	7.4
Guilty feelings	7.3	10.9	17.0	-2.2	-4.1
Pulse wave reflection index	7.1	8.7	10.6	-2.6	-3.3
Blood Platelet Count	6.9	79.7	104.0	7.4	10.2
Body mass index (BMI)	6.9	29.5	30.6	-5.3	-5.5
Qualifications: O levels/GCSEs or equivalent	6.8	10.9	14.2	3.8	2.8
Waist circumference	6.6	24.3	29.1	-5.4	-4.4
Comparative body size at age 10	6.6	18.3	21.9	-3.8	-4.7
Schizophrenia (2014)	6.1	13.5	15.2	3.4	3.9
Back pain experienced in last month	6.1	8.9	10.2	-3.2	-2.8
Financial difficulties in last 2 years	5.9	7.9	9.5	-3.1	-2.5
Medication: Omeprazole	5.6	6.7	7.5	-2.4	-2.7
Forced expiratory volume in 1-second (FEV1), predicted	5.6	11.7	17.7	2.4	4.2
Angina (self-reported)	5.5	7.3	8.0	-2.8	-2.6
Average weekly red wine intake	5.4	7.9	10.1	3.2	2.4
Impedance of leg (left)	5.3	25.8	28.7	4.8	5.4
Impedance of leg (right)	5.2	25.2	29.5	4.6	5.4
Breast Cancer	5.1	12.2	13.8	-3.2	-3.7
Angina	5.1	6.7	6.9	-2.5	-2.6
Leg fat percentage (left)	5.0	18.1	18.4	-4.3	-4.2
Depression (self-reported)	4.9	5.9	8.0	-2.8	-1.9
Bipolar Disorder (2011)	4.7	4.5	9.1	0.0	3.0
Sitting height	4.7	33.6	56.0	3.3	7.5
High cholesterol (Self-reported)	4.7	8.3	9.8	-3.1	-2.6
Height	4.6	87.9	141.6	5.8	11.9
Leg fat percentage (right)	4.6	16.8	17.9	-4.2	-4.0
Mother’s age at death	4.6	5.8	7.8	-1.9	-2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.5	5.3	5.5	-2.3	-2.3
Breastfed as a baby	4.4	5.4	6.1	2.2	2.5
Hearing aid user	4.3	4.8	5.7	-2.4	-2.0
Schizophrenia (2018)	4.2	8.8	8.9	2.9	3.0
Leg fat mass (left)	4.2	16.3	20.2	-4.5	-3.5
Diverticular disease/diverticulitis (self-reported)	4.1	4.8	7.1	-2.7	-1.6
Leg fat mass (right)	4.1	15.8	20.3	-4.5	-3.4
Medication: Omeprazole (e.g. Zanprol)	4.1	5.0	6.3	-1.9	-2.5
Ovarian Cancer	4.0	5.3	5.6	-2.4	-2.2
Medication for pain relief, constipation, heartburn	4.0	6.8	7.9	2.4	2.8
Worry (Nagel 2018)	3.9	8.2	12.0	2.1	3.5
Blood Eosinophil Count	3.9	30.3	41.5	4.4	6.4
Long-standing illness, disability or infirmity	3.9	6.0	8.0	-2.0	-2.8
Medication: Levothyroxine sodium	3.8	6.5	8.4	2.1	2.9
Standing height	3.8	37.7	64.5	3.3	8.0
Mouth/teeth dental problems	3.7	5.6	5.8	2.3	2.4
Sensitivity / hurt feelings	3.6	6.2	7.2	2.7	2.3
Migraine (self-reported)	3.6	4.4	5.4	-1.9	-2.3
Ever unenthusiastic/disinterested for a whole week	3.5	4.3	4.9	-2.2	-1.9
Medication: Simvastatin	3.5	5.1	6.2	-2.5	-2.0
Hypothyroidism/myxoedema (self-reported)	3.5	6.8	6.8	2.6	2.6
Chest pain or discomfort	3.5	5.0	5.5	-2.1	-2.4
Arm fat percentage (left)	3.4	13.5	19.2	-4.4	-2.8
Financial situation satisfaction	3.4	4.2	6.1	-2.5	-1.5
Ever had prostate specific antigen (PSA) test	3.4	3.9	5.2	-1.6	-2.3
Ulcerative Colitis (UC)	3.3	6.2	6.4	2.4	2.5
Mean Putamen Volume	3.3	3.7	4.4	1.8	2.1
Arm fat mass (right)	3.3	13.6	19.0	-4.4	-2.9
Medication for cholesterol, blood pressure or diabetes	3.3	5.4	6.2	2.1	2.5
Arm fat mass (left)	3.3	13.5	19.4	-4.4	-2.8
Triglycerides	3.0	4.8	8.8	-3.0	-1.0
Number of self-reported non-cancer illnesses	3.0	5.1	6.3	-2.5	-2.0
Age when periods started (menarche)	2.9	7.0	9.1	2.2	3.0
Alcohol usually taken with meals	2.9	4.7	5.6	2.4	1.9
Arm fat percentage (right)	2.9	11.6	15.9	-4.0	-2.7
Ever taken oral contraceptive pill	2.9	3.2	5.3	-1.0	-2.3
Frequency of depressed mood in last 2 weeks	2.8	3.9	6.5	-1.2	-2.5
Father’s age at death	2.8	3.8	6.1	1.2	2.5
Health satisfaction	2.8	3.6	6.3	-0.9	-2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.8	3.3	4.1	-1.6	-2.0
Age started oral contraceptive pill	2.8	3.6	4.7	1.6	2.2
Body Mass Index (BMI) (2010)	2.7	3.7	4.0	-1.9	-2.0
Nervous feelings	2.7	5.1	7.0	1.8	2.6
High blood pressure (mother)	2.6	3.7	5.7	1.3	2.4
Breast cancer (self-reported)	2.6	3.1	5.9	0.5	2.4
Eye problems/disorders: Glaucoma	2.6	3.1	3.3	-1.7	-1.8
Risk taking	2.6	3.7	6.7	0.9	2.6
Systolic Blood Pressure	2.5	12.4	16.4	2.9	4.0
Illness, injury, bereavement, stress in last 2 years	2.4	2.9	3.5	1.9	1.5
Wheeze or whistling in the chest in last year	2.3	4.0	5.6	-2.4	-1.6
Mean time to correctly identify matches	2.3	4.4	8.0	-0.9	-2.8
Whole body fat mass	2.3	9.5	15.4	-3.9	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	3.9	2.0	1.2
Medication: Aspirin	2.3	3.0	5.3	-0.9	-2.3
Heart disease (siblings)	2.3	2.8	5.4	-2.3	-0.4
Depression (Nagel 2018)	2.2	3.3	4.1	-1.6	-2.0
Lupus	2.2	3.4	3.8	1.7	2.0
Prostate Cancer	2.1	2.9	5.9	2.4	0.0
Waist Hip Ratio (WHR)	2.1	9.2	10.0	-2.9	-3.2
Body fat percentage	2.1	8.2	12.7	-3.6	-1.9
Emphysema/chronic bronchitis	2.1	2.3	3.3	-1.8	-1.1
Respiratory disease	2.0	4.4	8.0	-2.8	-0.9
Chronic bronchitis/emphysema (father)	2.0	2.3	3.2	-1.8	-1.2
Chronic bronchitis/emphysema (mother)	2.0	2.3	3.4	-1.1	-1.8
Irritable Bowel Disease (IBD)	1.9	4.6	5.0	2.0	2.2
HbA1C	1.9	2.2	3.3	-1.0	-1.8
Medication: Ramipril	1.9	2.4	3.4	1.9	1.2
LDL Cholesterol	1.8	2.9	5.7	-2.4	-0.0
Hypothyroidism (self reported)	1.8	4.2	5.4	1.7	2.3
Pain all over the body in last month	1.8	1.9	2.1	-1.3	-1.4
Medication: Atorvastatin	1.8	2.3	2.3	-1.5	-1.5
Number of treatments/medications taken	1.7	3.0	5.6	-0.7	-2.4
Pulse rate	1.7	2.9	4.7	2.2	1.0
Asthma	1.7	3.4	6.7	-2.6	-0.3
Glaucoma (self-reported)	1.7	2.0	3.5	-0.7	-1.9
Illnesses of father: Heart disease	1.7	2.4	3.8	-2.0	-1.0
Asthma (self-reported)	1.7	3.4	6.7	-2.6	-0.3
Weight	1.6	8.0	13.2	-3.6	-1.7
Heart disease (mother)	1.6	2.0	2.8	-1.7	-1.1
Loneliness, isolation	1.6	2.2	3.8	-0.8	-1.9
Miserableness	1.6	2.8	3.0	-1.7	-1.6
Alzheimer’s Disease (in father)	1.5	1.6	1.6	-1.2	-1.3
Reaction Time	1.5	2.9	5.6	-0.4	-2.4
Cardiovascular Disease	1.5	5.1	5.2	-2.2	-2.3
Hip circumference	1.5	6.6	10.8	-3.3	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	3.5	-1.9	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	2.7	1.6	0.9
Eye problems/disorders: Cataract	1.5	1.7	3.2	1.8	-0.4
Average weekly spirits intake	1.4	1.8	3.1	-0.7	-1.8
Trunk fat mass	1.4	6.0	11.5	-3.4	-0.8
Medication: Ventolin 100micrograms inhaler	1.4	1.8	3.4	-1.8	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	3.7	0.8	1.9
Major Depression (MDD)	1.3	1.6	3.0	-1.7	-0.5
Lung FEV1/FVC ratio	1.3	6.5	13.0	-0.3	-3.6
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	2.6	0.6	-1.6
Relative age voice broke	1.3	1.9	2.5	1.2	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	2.7	-1.6	-1.2
Forced vital capacity (FVC), Best measure	1.3	4.8	9.0	0.7	3.0
Shortness of breath walking on level ground	1.3	1.6	2.2	-1.5	-0.9
Suffer from ‘nerves’	1.3	2.0	4.1	0.1	2.0
Qualifications: nursing, teaching	1.3	2.0	2.2	-1.4	-1.5
Trunk fat percentage	1.2	4.8	9.4	-3.1	-0.6
Qualifications: CSEs or equivalent	1.2	1.6	3.1	-1.8	-0.4
Had menopause	1.2	1.5	2.9	-0.2	-1.7
Mouth/teeth dental problems: Loose teeth	1.2	1.5	1.6	1.3	1.1
Family relationship satisfaction	1.2	1.5	2.8	-0.4	-1.7
Medication: Aspirin	1.2	1.6	3.1	-0.2	-1.8
Commuting to job workplace: Walk	1.2	1.3	2.5	0.2	-1.6
Medication: Lisinopril	1.2	1.6	1.9	-1.4	-1.1
Ever depressed for a whole week	1.2	1.5	2.3	-1.5	-0.8
Pain experienced in last month	1.2	1.9	2.4	1.2	1.6
Type 2 Diabetes (T2D) (2012)	1.1	1.2	1.8	1.3	0.8
Blood Red Count	1.1	10.7	16.4	-2.2	-4.0
Medication: Lansoprazole	1.1	1.3	2.5	-0.3	-1.6
Length of working week for main job	1.1	1.2	2.2	-1.5	0.3
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.1	0.7	1.5
Illnesses of father: None of the above (group 1)	1.1	1.3	2.6	1.6	0.1
Age at First Birth	1.0	1.5	2.2	0.9	1.5
Systolic blood pressure, automated reading	1.0	3.0	5.4	0.7	2.3
Stomach or abdominal pain in last month	1.0	1.2	2.3	1.5	0.2
Forced vital capacity (FVC)	1.0	3.8	6.5	1.0	2.5
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	1.5	-1.2	-1.1
Prospective memory result	1.0	1.2	1.5	1.2	0.9
Tense / ‘highly strung’	1.0	1.6	2.1	1.1	1.4
Number of children fathered	1.0	1.1	2.0	-1.4	-0.4
Neck or shoulder pain in last month	1.0	1.4	2.0	1.4	0.9
Medication: Ibuprofen	1.0	1.2	1.2	-1.1	-1.1
Arm predicted mass (right)	1.0	5.0	7.1	-2.7	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	1.6	1.3	0.7
Medication for cholesterol	1.0	1.5	2.9	-1.7	-0.1
Osteoporosis (self-reported)	1.0	1.2	2.5	-0.0	-1.6
Irritability	1.0	1.7	3.4	-0.1	1.9
Supplements: Calcium	1.0	1.1	1.6	1.3	0.8
Allergy or Eczema	0.9	2.3	3.5	1.0	1.9
Chronotype (morning person)	0.9	2.1	3.9	2.0	0.6
Supplements: Zinc	0.9	1.0	1.9	-1.4	-0.3
Leg fat-free mass (left)	0.9	4.8	9.0	-3.0	-0.8
Leg predicted mass (left)	0.9	4.8	9.0	-3.0	-0.8
Noisy workplace	0.9	1.1	1.7	1.3	0.7
Medication: Allopurinol	0.9	1.2	2.3	1.5	0.0
Had major operations	0.9	1.0	1.9	0.3	-1.4
Smoking status: Previous	0.9	1.4	2.6	-1.6	-0.4
Vascular/heart problems diagnosed by doctor	0.9	2.3	2.9	1.3	1.7
Crohns Disease (2017)	0.8	1.7	2.0	1.2	1.4
Fasting Glucose	0.8	1.0	2.0	1.4	-0.2
Blood White Count	0.8	6.2	8.4	2.0	2.9
Diabetes (mother)	0.8	1.0	1.0	1.0	1.0
Severe depression (siblings)	0.8	0.9	0.9	0.9	1.0
Happiness	0.8	0.9	1.4	-0.7	-1.2
Arm fat-free mass (right)	0.8	4.4	6.6	-2.6	-1.5
Leg fat-free mass (right)	0.8	4.3	7.7	-2.8	-0.9
Friendships satisfaction	0.8	1.1	1.2	-1.0	-1.1
Osteoarthritis (self-reported)	0.8	1.0	1.2	-1.1	-0.9
Leg predicted mass (right)	0.8	4.2	7.6	-2.8	-0.9
Basal metabolic rate	0.8	4.5	8.0	-2.8	-1.0
Arm fat-free mass (left)	0.8	4.2	6.5	-2.6	-1.4
Arm predicted mass (left)	0.8	4.0	6.2	-2.5	-1.4
Alzheimer’s Disease (including proxy)	0.7	1.0	1.6	-1.2	-0.7
Hand grip strength (left)	0.7	1.8	2.3	1.5	1.2
Ever had hysterectomy (womb removed)	0.7	0.8	1.6	1.2	-0.1
Average weekly fortified wine intake	0.7	0.9	1.5	0.4	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.0	-1.0	-1.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.6	-0.1	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.4	-0.9	-1.2
Comparative height size at age 10	0.7	3.6	7.0	0.5	2.6
Overall health rating	0.7	1.5	1.8	-1.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.9	-0.2	-1.7
Wears glasses or contact lenses	0.7	0.8	1.0	1.0	0.8
Ever smoked	0.7	1.2	2.2	-1.5	-0.5
Number of operations (self-reported)	0.7	1.1	2.1	-0.3	-1.4
Depressed Affect (Nagel 2018)	0.6	1.3	1.5	-1.2	-1.0
Neuroticism (Nagel 2018)	0.6	1.4	1.9	0.9	1.4
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	0.8	-0.9	-0.8
Hayfever, allergic rhinitis or eczema	0.6	1.3	1.7	0.9	1.3
Past tobacco smoking	0.6	1.2	2.3	1.5	0.3
Hearing difficulty/problems with background noise	0.6	0.9	1.3	0.8	-1.1
Medication: Paracetamol	0.6	0.9	1.0	-1.0	-0.9
Whole body fat-free mass	0.6	3.4	6.0	-2.4	-0.9
Diabetes diagnosed by doctor	0.6	1.0	1.0	1.0	-1.0
Whole body water mass	0.6	3.7	6.3	-2.5	-1.0
Commuting to job workplace: Public transport	0.6	0.8	1.5	0.1	-1.2
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.3	1.1	-0.4
Medication: Paracetamol	0.6	1.0	1.3	-1.1	-0.8
Alcohol drinker status: Previous	0.6	0.6	1.3	1.1	0.1
Pack years of smoking	0.6	0.9	0.9	-0.9	0.9
Medication for hormone replacement therapy	0.5	0.5	0.6	0.8	-0.7
Supplements: Glucosamine	0.5	0.6	1.1	0.3	1.1
Diabetes (self-reported)	0.5	0.8	1.3	1.1	-0.6
Hair/balding pattern: Pattern 3	0.5	0.8	1.0	-0.8	-1.0
Qualifications: A levels/AS levels or equivalent	0.5	1.0	1.7	1.3	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	2.4	0.8	1.5
Exposure to tobacco smoke at home	0.5	0.6	1.2	0.0	1.1
Loud music exposure frequency	0.5	0.6	1.0	1.0	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.1	-0.5	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.7	1.3	-0.0	-1.1
Hypertension (Self-reported)	0.5	1.4	1.9	-1.0	-1.4
Diastolic blood pressure, automated reading	0.5	1.5	2.7	-1.6	-0.5
Schizophrenia vs Biploar Disorder	0.4	0.6	0.6	0.8	-0.7
Neuroticism	0.4	1.0	1.2	0.9	1.1
Vitamin and mineral supplements	0.4	0.5	0.5	0.6	-0.7
Pack years adult smoking proportion	0.4	0.6	0.8	-0.6	0.9
High blood pressure	0.4	1.0	1.1	-1.0	-1.1
Multivitamins +/- minerals	0.4	0.6	1.0	-1.0	0.4
Had other major operations	0.4	0.5	0.9	-0.9	0.3
Falls in the last year	0.4	0.5	1.0	-0.1	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.8	-0.9	0.0
Hair/balding pattern: Pattern 4	0.4	1.0	1.4	-0.7	-1.2
Headache pain in last month	0.4	0.6	1.2	-1.1	-0.2
Gout (self-reported)	0.4	0.6	0.9	0.9	-0.5
High blood pressure (siblings)	0.4	0.6	1.0	0.5	1.0
Eye problems/disorders: None of the above	0.4	0.5	0.9	0.0	1.0
Number of full sisters	0.4	0.5	0.7	0.5	0.9
Mineral and other dietary supplements	0.4	0.5	0.9	1.0	0.1
Medication: Gliclazide	0.4	0.5	0.6	0.6	-0.8
Alcohol drinker status: Never	0.4	0.5	0.5	0.7	0.7
Unable to work because of sickness or disability	0.4	0.5	0.7	-0.9	-0.5
Cholesterol lowering medication	0.4	0.5	0.6	0.7	0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.8	0.2	-0.9
Diabetes (father)	0.3	0.4	0.4	0.6	0.7
Taking other prescription medications	0.3	0.5	0.8	0.9	-0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	0.5	0.5	0.7
Number of incorrect matches in round	0.3	0.4	0.8	0.2	-0.9
Trunk fat-free mass	0.3	1.8	3.2	-1.8	-0.6
Alcohol intake versus 10 years previously	0.3	0.4	0.6	-0.8	0.5
Number of live births	0.3	0.4	0.6	0.8	-0.5
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	1.7	0.7	1.3
Trunk predicted mass	0.3	1.8	3.3	-1.8	-0.6
Peak expiratory flow (PEF)	0.3	0.7	1.0	-1.0	-0.7
Age at first live birth	0.3	0.5	0.6	0.8	0.6
Medication: Blood pressure	0.3	0.5	0.9	-0.3	-0.9
Medication: Seretide 50 evohaler	0.3	0.4	0.7	-0.8	0.0
Alcohol intake frequency.	0.3	0.8	1.1	0.7	1.0
Leg pain on walking	0.3	0.3	0.4	0.5	-0.7
Supplements: Vitamin C	0.3	0.4	0.5	-0.5	0.7
Knee pain experienced in last month	0.3	0.5	0.7	-0.8	-0.6
Illnesses of siblings: Diabetes	0.3	0.4	0.7	0.8	0.1
Medication: Blood pressure	0.3	0.5	1.0	1.0	0.3
Basal cell carcinoma (self-reported)	0.3	0.3	0.4	-0.6	0.6
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.9	-0.9	-0.2
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	-0.7	0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.6	-0.7	-0.8
Neuroticism (2016)	0.2	0.3	0.4	0.4	-0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.8	0.2	-0.9
Medication: Metformin	0.2	0.2	0.4	-0.2	-0.6
Fed-up feelings	0.2	0.4	0.7	-0.2	-0.9
Hair/balding pattern: Pattern 2	0.2	0.2	0.4	-0.1	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.8	-0.9	-0.5
Heart attack	0.2	0.2	0.3	0.3	0.6
Fluid intelligence score	0.2	0.4	0.5	-0.4	-0.7
Illnesses of siblings	0.2	0.2	0.5	0.7	-0.1
Mouth/teeth dental problems: Dentures	0.2	0.4	0.8	-0.9	-0.0
Lung cancer (father)	0.2	0.3	0.3	-0.6	-0.4
Medication: Amlodipine	0.2	0.3	0.3	-0.5	-0.6
Birth weight	0.2	0.4	0.7	0.2	0.8
Number of full brothers	0.2	0.2	0.4	-0.3	0.6
Worry too long after embarrassment	0.2	0.3	0.6	0.8	-0.0
Pulse wave peak to peak time	0.2	0.3	0.4	0.3	0.7
Pulse rate, automated reading	0.2	0.6	1.0	0.5	1.0
Average weekly champagne plus white wine intake	0.2	0.3	0.6	-0.2	-0.8
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.4	-0.4	-0.6
Fractured/broken bones in last 5 years	0.2	0.3	0.5	-0.3	-0.7
Coronary Artery Disease (CAD)	0.1	0.2	0.3	0.5	-0.2
Heel T-Score	0.1	0.6	1.0	-0.5	-1.0
Hair Pigment	0.1	2.5	4.6	-0.6	-2.1
Tanning	0.1	1.0	1.7	-0.6	-1.3
Relative age of first facial hair	0.1	0.3	0.5	0.2	-0.7
Medication: Co-codamol	0.1	0.1	0.2	-0.2	0.4
Current tobacco smoking	0.1	0.1	0.2	0.4	0.1
Serious illness, injury or assault to yourself	0.1	0.2	0.3	-0.2	-0.5
Medication: Atenolol	0.1	0.1	0.1	-0.3	-0.3
Qualifications: None of the above	0.1	0.2	0.5	-0.7	0.0
Allergy	0.1	0.3	0.3	0.5	-0.6
Illnesses of mother	0.1	0.1	0.1	-0.2	-0.3
Birth weight of first child	0.1	0.3	0.5	-0.2	0.7
Blood clot in the leg (DVT)	0.1	0.1	0.3	-0.5	-0.1
Exposure to tobacco smoke outside home	0.1	0.1	0.2	-0.2	0.4
Age at last live birth	0.1	0.2	0.3	0.6	0.0
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	0.4	0.1
Ever had bowel cancer screening	0.1	0.1	0.3	-0.5	0.0
Smoking status: Current	0.1	0.2	0.3	0.6	0.3
Medication: Bendroflumethiazide	0.1	0.1	0.1	0.4	-0.2
Illnesses of father: High blood pressure	0.1	0.2	0.2	0.3	0.5
Average weekly beer plus cider intake	0.1	0.1	0.3	0.1	0.5
Commuting to job workplace: Cycle	0.1	0.2	0.3	-0.6	-0.0
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	0.2	0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.3	-0.6	-0.1
Crohns Disease (2012)	0.0	0.0	0.0	-0.2	-0.1
HDL Cholesterol	0.0	0.1	0.1	0.2	0.2
Primary Biliary Cirrhosis	0.0	0.0	0.1	-0.0	-0.3
Ulcerative Colitis	0.0	0.1	0.1	0.3	-0.1
Smoking Status	0.0	0.1	0.2	-0.2	-0.4
Lung FVC	0.0	0.0	0.0	0.1	-0.1
Hand grip strength (right)	0.0	0.1	0.1	0.2	0.3
Maternal smoking around birth	0.0	0.0	0.0	0.1	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	-0.4	-0.1
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	0.3	0.1
Neuroticism score	0.0	0.0	0.1	0.0	0.2
Time employed in main current job	0.0	0.0	0.0	0.0	-0.2
Worrier / anxious feelings	0.0	0.1	0.1	0.3	-0.0
Pulse wave Arterial Stiffness index	0.0	0.0	0.0	-0.0	0.1
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	0.2	-0.0
Qualifications: College or University degree	0.0	0.0	0.1	0.0	-0.3
Mood swings	0.0	0.0	0.0	0.1	0.2
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.0	-0.0	0.1

Hub : Genes

CILP2

Models

Trait associations