Best TWAS P=1.87e-08 · Best GWAS P=2.4e-16 conditioned to 1.24e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Atrial Appendage | PROS1 | 0.31 | 0.16 | enet | 7 | 0.19 | 8.4e-09 | 5.5 | -5.1 | 2.8e-07 | -0.68 | 0.96 | 0.02 | FALSE |
| 2 | YFS | Blood | DHFRL1 | 0.07 | 0.04 | lasso | 9 | 0.04 | 4.1e-14 | 5.7 | 5.5 | 3.3e-08 | 0.54 | 1.00 | 0.00 | TRUE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | STX19 | 0.04 | 0.02 | lasso | 1 | 0.01 | 5.5e-04 | 5.3 | 5.3 | 9.5e-08 | 0.64 | 0.01 | 0.86 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DHFRL1 | 0.07 | 0.05 | enet | 17 | 0.05 | 2.5e-06 | 4.3 | -5.2 | 1.9e-07 | -0.54 | 0.05 | 0.91 | FALSE |
| 5 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | STX19 | 0.15 | 0.08 | lasso | 1 | 0.05 | 1.8e-03 | 5.3 | 5.3 | 9.5e-08 | 0.64 | 0.01 | 0.74 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | ARL13B | 0.03 | 0.00 | blup | 39 | 0.00 | 2.1e-01 | -5.5 | 5.6 | 1.9e-08 | 0.66 | 0.01 | 0.68 | TRUE |