Hub : Genes

MAPKAPK5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0754	0.0333	2.1e-04	0.037	NA	0.012	NA	0.021	1.3e-04	NA	2.1e-02	NA	3.6e-03
2	GTEx	Nerve Tibial	0.0650	0.0359	7.8e-03	0.008	NA	0.018	NA	0.012	7.6e-02	NA	1.8e-02	NA	4.5e-02
3	GTEx	Testis	0.2330	0.0860	3.7e-06	0.117	NA	0.108	NA	0.151	7.1e-06	NA	1.7e-05	NA	3.1e-07
4	YFS	Blood	0.0346	0.0151	1.0e-11	0.045	0.035	0.041	0.037	0.041	1.5e-14	1.1e-11	1.9e-13	3.3e-12	1.7e-13
5	TCGA	Breast Invasive Carcinoma	0.0371	0.0208	7.4e-05	0.021	0.018	0.018	NA	0.020	3.0e-05	1.1e-04	8.7e-05	NA	5.4e-05
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0633	0.0368	1.2e-03	0.026	0.025	0.021	NA	0.025	5.3e-04	7.1e-04	1.7e-03	NA	6.5e-04
7	TCGA	Brain Lower Grade Glioma	0.0273	0.0198	2.5e-03	0.010	0.010	0.002	NA	0.007	2.3e-02	2.5e-02	1.6e-01	NA	4.8e-02
8	TCGA	Lung Squamous Cell Carcinoma	0.0642	0.0423	8.1e-03	0.017	0.014	0.015	NA	0.014	4.7e-03	8.8e-03	7.4e-03	NA	8.7e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bipolar Disorder (2018)	1.7	2.7	5.0	1.5	-1.8	1.2	2.2	1.7	1.8	0.8	1.6
Bipolar Disorder or Schizophrenia	0.5	1.3	4.1	0.8	-1.3	0.5	1.5	0.8	0.9	-0.0	2.0
Depressed Affect (Nagel 2018)	3.0	6.4	11.2	-2.7	-1.9	-2.8	2.6	-2.3	-2.2	-3.3	-2.0
Depression (Nagel 2018)	2.5	3.8	8.8	-1.3	-2.2	-2.1	3.0	-1.5	-1.2	-2.6	-0.3
Intelligence (Savage-Jansen 2018)	1.3	3.9	8.0	1.7	2.2	1.9	-2.8	1.2	1.2	2.4	1.6
Neuroticism (Nagel 2018)	1.3	3.1	6.0	-1.5	-2.4	-1.6	2.3	-1.3	-1.1	-2.1	-1.2
Schizophrenia (2018)	0.2	0.3	1.8	-0.2	-0.1	-0.3	0.1	-0.4	-0.3	-0.7	1.3
Schizophrenia vs Biploar Disorder	0.8	1.1	5.4	-0.0	1.6	0.1	-2.3	-0.6	-0.6	0.4	0.1
Worry (Nagel 2018)	0.8	1.8	4.9	-1.0	-1.9	-1.0	2.2	-0.7	-0.6	-1.6	0.2
Alzheimer’s Disease (in mother)	1.1	1.3	2.0	1.2	1.0	1.1	0.7	1.4	1.4	1.0	1.1
Alzheimer’s Disease (in father)	0.0	0.0	0.0	0.2	-0.2	-0.2	0.1	-0.1	-0.1	-0.0	0.1
Alzheimer’s Disease (including proxy)	0.6	0.9	1.5	1.2	0.3	0.7	1.1	1.2	1.2	0.8	0.5
Crohns Disease (2017)	0.1	0.3	1.1	-0.2	-1.0	0.2	-0.7	-0.4	-0.5	0.1	-0.6
Irritable Bowel Disease (IBD)	0.3	0.7	4.1	0.0	-0.5	0.7	-2.0	-0.3	-0.3	0.7	-0.3
Ulcerative Colitis (UC)	0.6	1.1	4.9	0.6	0.2	1.0	-2.2	0.4	0.3	1.3	0.3
Major Depression (MDD)	0.5	0.6	1.0	-1.0	-0.3	-0.9	0.0	-1.0	-0.9	-1.0	-0.6
Reaction Time	8.4	16.1	28.4	4.4	-0.2	5.3	-2.8	4.4	4.2	5.3	2.6
Verbal and Numeric Reasoning (VNR)	1.7	4.1	12.5	1.5	3.0	1.2	-3.5	0.7	0.8	2.2	1.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.5	0.6	1.6	1.2	-0.3	0.5	-0.2	0.8	0.8	1.1	0.9
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.4	0.6	1.0	-0.5	0.3	-1.0	-1.0	-1.0	-0.9	-0.4	-0.7
Bipolar Disorder (2011)	0.5	0.5	1.0	-0.6	-0.8	-0.8	1.0	-0.5	-0.5	-0.8	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	4.4	-0.5	2.1	-0.7	-0.2	-0.5	-0.4	-0.5	0.1
Coronary Artery Disease (CAD)	3.2	3.9	9.1	1.4	-0.7	2.8	-1.9	2.1	1.8	3.0	0.3
Crohns Disease (2012)	0.1	0.1	0.2	-0.3	-0.3	-0.0	-0.5	-0.4	-0.4	0.1	0.0
Mean Putamen Volume	2.8	3.2	4.8	-2.1	0.5	-2.2	0.3	-2.1	-2.1	-2.1	-1.8
Fasting Glucose	2.7	3.2	5.1	-2.1	2.3	-1.5	-1.4	-1.8	-1.9	-1.3	-1.8
HbA1C	3.9	4.3	21.2	1.0	-2.4	0.2	4.6	1.6	1.6	-0.4	1.0
HDL Cholesterol	0.6	1.1	4.3	0.9	2.1	0.4	0.2	0.8	0.9	0.8	1.0
LDL Cholesterol	6.6	10.4	21.0	-3.6	-0.0	-4.2	2.8	-3.4	-3.2	-4.6	-1.6
Lupus	1.7	2.6	5.1	1.4	-0.1	2.3	-1.5	1.7	1.5	2.1	1.4
Neuroticism (2016)	0.2	0.3	1.1	-0.1	-0.9	-0.4	0.2	-0.2	-0.2	-0.1	-1.0
Primary Biliary Cirrhosis	3.6	5.2	9.9	2.3	0.2	3.1	-2.7	2.1	2.0	3.2	1.2
Rheumatoid Arthritis	1.2	1.7	3.8	0.9	-1.2	1.9	-1.0	1.3	1.1	1.9	0.0
Schizophrenia (2014)	0.3	0.7	3.5	-0.3	-1.9	-0.4	0.6	-0.5	-0.4	-0.8	0.0
Triglycerides	1.4	2.2	3.4	-1.7	-0.6	-1.3	-1.4	-1.7	-1.8	-1.1	-1.8
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.9	-1.0	0.7	-0.4	-1.7	-1.3	-1.4	0.1	-1.5
Ulcerative Colitis	0.3	0.4	2.0	-0.4	-0.3	-0.2	-1.4	-0.8	-0.8	-0.0	0.0
Blood Eosinophil Count	36.5	281.0	524.4	18.0	-6.9	22.9	-12.0	17.2	16.6	21.2	13.7
Blood Platelet Count	5.1	58.9	376.4	-5.0	-19.4	0.3	-0.9	-4.8	-5.1	-4.4	-0.8
Blood Red Count	4.7	45.3	125.1	5.4	0.6	8.6	-11.2	4.8	4.3	8.8	3.8
Blood White Count	13.6	100.9	193.2	10.3	-1.7	13.9	-10.8	9.5	9.0	13.6	5.6
Heel T-Score	0.1	0.6	2.5	0.9	-0.1	0.6	-1.6	0.1	0.2	0.8	0.8
BMI	0.4	2.6	5.7	-1.6	1.3	-2.4	1.0	-1.8	-1.6	-2.1	0.2
Height	1.0	19.1	31.4	-5.0	1.6	-5.6	0.1	-5.4	-5.2	-5.2	-3.3
Waist Hip Ratio (WHR)	0.3	1.1	3.6	0.4	-0.4	1.6	-1.9	0.8	0.5	1.3	0.2
Systolic Blood Pressure	7.2	36.2	66.7	5.8	1.8	8.1	-6.9	5.8	5.3	8.2	3.2
Smoking Status	1.7	4.0	14.1	-1.3	1.0	-1.3	-3.8	-2.3	-2.4	-0.5	-1.4
Allergy or Eczema	0.5	1.3	6.5	0.9	0.2	-0.6	2.5	0.6	0.8	-0.4	1.2
Cardiovascular Disease	5.4	17.9	31.3	4.0	2.5	5.3	-5.1	3.7	3.5	5.6	2.9
Hypothyroidism (self reported)	19.8	45.5	91.0	7.0	-4.7	9.5	-3.9	7.2	6.8	8.6	3.7
Respiratory disease	0.6	1.2	3.0	1.7	0.4	0.8	-0.1	1.2	1.3	1.4	1.1
Type 2 Diabetes (T2D) (2018)	0.7	1.2	5.6	0.3	0.7	1.2	-2.4	0.3	0.2	1.2	0.8
Lung FEV1/FVC ratio	0.3	1.3	2.3	-0.6	0.7	-1.4	1.2	-1.0	-0.8	-1.5	1.5
Lung FVC	2.0	10.3	14.5	3.7	-1.9	3.8	0.6	3.8	3.8	3.3	3.3
Neuroticism	1.2	2.8	4.2	-1.6	-1.8	-1.7	1.8	-1.4	-1.3	-2.0	-1.4
Chronotype (morning person)	4.2	9.7	19.6	3.0	1.5	3.8	-3.7	3.1	2.9	4.4	0.6
Hair Pigment	0.8	22.3	38.3	-5.2	0.5	-6.2	0.9	-5.6	-5.5	-5.5	-4.4
Tanning	0.5	5.7	10.5	2.1	-0.2	3.2	-2.6	2.3	2.1	3.0	2.4
Hand grip strength (left)	0.3	0.8	3.1	-0.4	1.8	-0.8	-1.0	-0.7	-0.7	-0.2	-0.7
Number of treatments/medications taken	2.1	3.9	8.1	1.7	0.0	2.9	-2.0	2.0	1.8	2.6	1.1
Average weekly spirits intake	0.4	0.5	2.0	0.3	0.1	-0.5	-1.4	-0.7	-0.6	0.2	-0.8
Sensitivity / hurt feelings	2.6	4.4	7.9	2.2	-0.2	2.5	1.0	2.8	2.8	2.1	1.8
Frequency of depressed mood in last 2 weeks	2.1	2.9	8.9	-0.9	-3.0	-1.4	2.5	-1.0	-0.8	-1.9	-0.1
Hearing difficulty/problems: Yes	0.3	0.5	3.2	-0.2	-0.2	0.2	-0.6	0.1	-0.0	0.5	-1.8
Relative age of first facial hair	0.7	1.5	3.5	0.8	0.7	1.4	-1.9	0.9	0.8	1.5	1.1
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	3.4	1.2	-1.1	1.7	-0.4	1.3	1.3	1.3	1.8
Ever used hormone-replacement therapy (HRT)	1.7	2.1	6.0	-1.2	-1.7	-1.5	-0.0	-1.3	-1.3	-1.0	-2.4
Ever had hysterectomy (womb removed)	0.4	0.5	1.3	-0.2	-1.0	-0.6	0.9	-0.3	-0.3	-0.4	-1.1
Systolic blood pressure, automated reading	4.0	11.6	22.9	3.3	1.2	4.5	-4.5	3.1	2.8	4.8	0.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.6	-0.4	-0.8	-0.2	-0.0	-0.5	-0.5	-0.4	-0.4
Angina	0.6	0.8	3.9	-0.0	0.4	0.9	-2.0	-0.0	-0.1	0.7	0.8
Medication for hormone replacement therapy	1.4	1.5	3.8	-1.1	-1.9	-0.6	1.8	-0.3	-0.4	-1.1	-1.5
Vitamin and mineral supplements	0.4	0.6	2.4	1.0	-0.3	0.6	-1.5	0.0	0.1	0.9	0.4
Supplements: Zinc	1.1	1.2	2.1	-1.3	0.3	-1.4	0.2	-1.3	-1.3	-1.5	-0.2
Medication: Co-codamol	0.2	0.2	0.5	-0.4	-0.6	-0.3	0.6	-0.3	-0.2	-0.6	0.7
Medication: Metformin	0.6	0.8	2.5	-0.7	-1.4	-0.5	1.6	-0.4	-0.3	-1.0	-0.2
Diabetes (father)	0.7	0.8	3.8	-0.2	1.9	0.8	-1.3	0.4	0.2	0.6	0.1
Diabetes (mother)	0.4	0.5	3.0	-0.3	1.7	-0.2	-0.3	-0.3	-0.2	-0.1	0.6
Severe depression (siblings)	0.2	0.2	0.8	0.6	0.2	-0.2	-0.6	0.0	0.1	0.3	0.9
Pack years adult smoking proportion	1.4	2.2	4.5	-1.5	-0.3	-1.8	2.1	-1.2	-1.1	-2.1	-0.3
Impedance of leg (right)	0.4	2.0	4.2	-1.7	-1.6	-0.5	-0.7	-1.4	-1.6	-1.1	-2.0
Leg fat-free mass (left)	0.9	4.6	10.2	-2.0	1.7	-3.2	1.6	-2.3	-2.0	-2.8	0.3
Trunk fat percentage	0.8	3.3	5.8	-2.3	0.3	-2.2	-0.5	-2.4	-2.3	-2.2	-0.3
Hand grip strength (right)	0.3	0.7	4.5	0.3	2.1	0.2	-0.9	0.3	0.2	0.6	-0.2
Townsend deprivation index at recruitment	0.2	0.3	2.2	0.1	-1.5	0.5	-0.2	0.1	0.1	0.3	-0.0
Current tobacco smoking	9.1	15.0	22.4	-4.4	-0.4	-4.7	0.5	-4.7	-4.7	-4.5	-3.7
Average weekly fortified wine intake	0.0	0.0	0.1	-0.3	0.3	0.0	-0.3	0.1	-0.0	0.1	-0.2
Maternal smoking around birth	1.3	1.9	3.4	-1.5	-0.4	-1.4	-0.8	-1.6	-1.6	-1.2	-1.8
Fed-up feelings	6.3	11.5	19.6	-4.0	-1.7	-4.0	1.9	-3.7	-3.6	-4.4	-2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	3.3	4.4	7.4	-1.9	-2.2	-2.4	2.7	-1.8	-1.7	-2.7	-0.8
Relative age voice broke	1.0	1.5	9.7	-0.6	0.6	0.5	-3.1	-0.4	-0.6	0.7	-0.3
Taking other prescription medications	2.8	4.3	7.6	2.1	-1.3	2.8	-2.0	2.0	1.9	2.6	1.6
Age when periods started (menarche)	0.1	0.4	0.9	0.2	-0.3	1.0	-0.3	0.7	0.5	0.7	-0.7
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	2.1	1.4	-0.1	1.1	-0.0	1.3	1.4	1.4	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.0	-1.4	-0.1	-1.7	-0.2	-1.7	-1.7	-1.5	-1.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.3	-0.7	-0.6	-1.0	1.1	-0.7	-0.6	-1.2	0.2
Qualifications: CSEs or equivalent	0.9	1.2	1.8	-1.3	1.3	-0.8	-1.2	-1.0	-1.1	-0.7	-1.2
Serious illness, injury or assault to yourself	0.2	0.3	0.9	0.4	-0.9	0.5	-0.4	0.3	0.3	0.5	0.4
High blood pressure	5.9	16.4	29.2	3.9	2.3	5.2	-4.9	3.6	3.4	5.4	2.5
Hayfever, allergic rhinitis or eczema	0.7	1.4	5.7	1.1	1.0	-0.5	2.4	0.8	1.0	-0.1	1.3
Multivitamins +/- minerals	0.4	0.5	2.5	-0.7	0.4	-0.4	1.6	0.1	0.0	-0.8	0.2
Stomach or abdominal pain in last month	1.0	1.2	3.1	-1.8	0.0	-0.9	1.0	-0.8	-0.9	-1.4	-1.3
Supplements: Glucosamine	2.4	3.2	6.6	-1.6	1.9	-1.6	-1.6	-1.7	-1.8	-0.9	-2.6
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	4.0	-1.3	0.7	-2.0	1.2	-1.5	-1.4	-1.9	0.2
Medication: Atenolol	4.0	5.0	9.7	2.4	0.0	3.1	-2.4	2.1	2.0	3.1	1.0
Medication: Levothyroxine sodium	18.8	31.9	61.2	5.8	-1.5	7.8	-4.9	5.9	5.5	7.5	3.4
Sitting height	0.1	0.6	2.0	0.1	1.4	0.1	-0.7	-0.1	-0.0	0.2	1.4
Chronic bronchitis/emphysema (father)	0.6	0.7	1.6	-0.5	-0.5	-1.3	-0.3	-1.1	-1.0	-0.9	0.5
High blood pressure (mother)	1.3	1.9	7.2	0.4	1.9	1.1	-2.7	0.2	0.1	1.2	1.2
Body mass index (BMI)	0.9	3.8	7.8	-2.2	1.2	-2.8	0.6	-2.3	-2.2	-2.5	-0.3
Impedance of leg (left)	0.3	1.4	3.8	-1.3	-0.7	-0.2	-1.5	-1.1	-1.3	-0.5	-2.0
Leg predicted mass (left)	0.8	4.4	9.8	-1.9	1.6	-3.1	1.5	-2.3	-2.0	-2.8	0.3
Trunk fat mass	1.5	6.3	10.9	-3.0	0.7	-3.3	0.2	-3.2	-3.0	-3.2	-0.6
Waist circumference	1.9	7.0	12.2	-3.1	0.5	-3.5	1.1	-3.1	-3.0	-3.5	-1.3
Number of incorrect matches in round	1.6	2.7	4.3	1.8	-1.8	1.3	2.1	1.7	1.8	0.9	1.4
Past tobacco smoking	2.5	4.7	20.3	-1.7	-0.8	-2.0	4.5	-0.8	-0.7	-2.7	-0.9
Alcohol usually taken with meals	0.8	1.3	2.7	-1.4	1.5	-0.3	-1.6	-0.6	-0.9	-0.2	-1.5
Nervous feelings	1.7	3.1	10.1	0.6	-2.5	1.2	3.2	1.7	1.7	0.2	1.0
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	5.9	-1.6	-2.2	-2.0	2.4	-1.5	-1.4	-2.4	-0.3
Hearing difficulty/problems with background noise	0.5	0.8	1.5	-1.1	-0.6	-0.9	0.5	-0.8	-0.9	-1.0	-1.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.0	-0.6	0.3	0.2	0.5	0.3	0.1	0.3
Had menopause	0.6	0.7	1.9	-0.7	-0.9	-0.8	-0.5	-0.8	-0.8	-0.5	-1.4
Had other major operations	0.8	0.9	4.7	-0.2	2.2	0.2	-1.4	-0.0	-0.1	0.3	0.8
Forced vital capacity (FVC)	0.3	1.0	2.6	1.2	-0.4	0.9	0.4	1.0	1.1	0.8	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	3.2	-1.7	0.2	-1.6	-0.5	-1.8	-1.8	-1.5	-1.4
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	3.8	-2.0	-0.9	-1.5	0.5	-1.7	-1.7	-1.9	-1.1
Qualifications: None of the above	0.2	0.5	1.8	-0.3	-0.5	-0.5	-0.8	-0.7	-0.7	-0.3	-1.4
Financial difficulties in last 2 years	0.4	0.5	3.3	-0.4	-0.4	0.1	1.8	0.2	0.2	-0.5	-0.4
Mouth/teeth dental problems	1.5	2.3	3.8	1.9	1.1	1.4	-0.4	1.6	1.6	1.8	1.8
Heart attack	1.0	1.3	7.5	-0.2	0.9	0.9	-2.7	-0.1	-0.2	0.9	-0.5
Allergy	0.7	1.6	3.8	-1.6	-1.2	-0.0	-1.6	-1.0	-1.3	-0.4	-2.0
Pain all over the body in last month	0.2	0.2	0.6	-0.3	-0.1	-0.1	-0.7	-0.3	-0.4	0.1	-0.7
Diabetes (self-reported)	0.2	0.3	1.4	-0.0	0.2	0.8	-1.2	0.2	0.1	0.6	0.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.1	0.7	1.2	0.0	1.8	0.9	0.9	0.2	-0.1
Medication: Ramipril	1.2	1.6	8.5	0.1	1.2	1.1	-2.9	0.1	-0.0	1.2	0.4
Medication: Simvastatin	0.3	0.5	2.0	-0.6	0.8	0.2	-1.4	-0.4	-0.5	0.1	-0.6
Fluid intelligence score	1.5	3.1	6.0	2.0	1.3	1.6	-2.4	1.2	1.3	2.4	1.3
Illnesses of siblings	2.1	3.0	8.6	-1.0	-0.8	-2.1	2.9	-1.2	-1.0	-2.0	-1.5
Neuroticism score	1.8	3.8	9.7	-1.5	-3.1	-1.5	2.9	-1.1	-1.0	-2.2	-0.7
Weight	1.9	9.4	18.1	-3.4	1.8	-4.3	1.1	-3.6	-3.4	-3.9	-1.0
Impedance of arm (right)	0.4	2.1	8.4	0.7	-2.9	2.1	-0.2	1.1	1.0	1.1	0.0
Arm fat percentage (right)	0.6	2.4	4.1	-1.9	0.1	-2.0	0.1	-2.0	-1.9	-2.0	0.1
Trunk fat-free mass	1.8	10.6	21.9	-3.4	2.1	-4.7	1.8	-3.6	-3.4	-4.2	-1.4
Hip circumference	3.1	13.4	26.5	-4.0	1.2	-5.1	1.8	-4.3	-4.0	-4.8	-1.7
Time employed in main current job	0.0	0.0	0.1	-0.3	0.2	-0.1	-0.0	-0.2	-0.2	-0.3	0.0
Alcohol intake versus 10 years previously	0.7	1.0	3.0	0.6	-0.6	1.4	-1.7	0.7	0.5	1.3	-0.1
Father’s age at death	3.4	4.5	7.0	-2.6	0.7	-2.5	0.7	-2.2	-2.2	-2.5	-2.4
Worrier / anxious feelings	0.3	0.6	2.2	-0.6	-0.3	-0.8	1.5	-0.5	-0.4	-1.1	0.0
Frequency of tiredness / lethargy in last 2 weeks	7.3	11.8	19.7	-4.2	-0.7	-4.2	1.1	-4.1	-4.0	-4.4	-2.2
Falls in the last year	1.2	1.7	3.0	-1.6	-1.3	-1.2	0.8	-1.3	-1.3	-1.7	-0.8
Hair/balding pattern: Pattern 3	0.1	0.1	0.5	0.3	0.7	0.3	-0.1	0.3	0.3	0.2	0.4
Number of live births	0.7	1.0	2.7	-1.1	-0.2	-1.1	-0.4	-1.0	-1.1	-0.8	-1.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	6.4	1.5	0.3	1.2	0.1	1.2	1.3	1.1	2.5
Pulse rate	0.7	1.1	2.7	0.3	-0.4	1.6	-1.2	1.0	0.8	1.1	1.3
Happiness	0.1	0.2	0.3	-0.4	-0.1	-0.4	0.1	-0.6	-0.4	-0.5	0.4
Noisy workplace	0.4	0.5	1.3	-1.1	0.3	-0.6	-0.0	-0.7	-0.8	-0.8	-0.5
Qualifications: A levels/AS levels or equivalent	1.8	4.1	13.5	1.9	0.5	1.7	1.6	2.0	2.2	1.1	3.7
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	3.5	-0.5	1.9	0.0	-1.3	-0.3	-0.3	0.1	0.5
Mouth/teeth dental problems: Dentures	0.8	1.4	2.5	-1.4	-1.6	-0.9	-0.4	-1.3	-1.4	-1.2	-0.9
Asthma	0.3	0.7	1.1	1.1	0.4	0.4	0.9	0.9	1.0	0.6	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.5	4.6	-1.7	1.3	-1.7	2.1	-1.3	-1.1	-2.2	-0.5
Medication: Cholesterol lowering	0.4	0.6	2.6	0.1	1.1	0.5	-1.6	-0.1	-0.1	0.5	0.6
Depression (self-reported)	0.2	0.2	0.5	-0.3	-0.2	-0.7	-0.2	-0.6	-0.5	-0.5	-0.3
Medication: Lansoprazole	2.0	2.2	4.4	1.5	0.6	2.1	-1.1	1.6	1.5	1.9	1.1
Prospective memory result	0.2	0.3	0.9	0.4	-0.8	-0.2	1.0	0.2	0.3	-0.1	0.2
Lung cancer (father)	0.2	0.2	1.0	-0.2	-0.5	-0.2	1.0	0.2	0.2	-0.2	-0.6
Illnesses of mother	1.5	1.9	4.2	-1.3	-1.3	-1.5	2.1	-0.8	-0.8	-1.7	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	10.3	1.7	-0.5	1.6	0.8	1.6	1.7	1.1	3.2
Pulse wave Arterial Stiffness index	3.2	3.7	7.0	-2.5	-0.1	-0.9	-2.6	-1.9	-2.2	-1.0	-2.5
Impedance of arm (left)	1.0	4.4	10.2	1.7	-3.2	3.1	-0.7	2.0	1.9	2.2	0.4
Arm fat mass (right)	1.3	5.2	10.0	-2.6	1.0	-3.2	0.3	-2.8	-2.7	-2.9	-0.4
Trunk predicted mass	1.9	10.9	22.3	-3.4	2.1	-4.7	1.9	-3.7	-3.4	-4.2	-1.5
Standing height	0.9	8.5	14.1	-3.4	1.2	-3.8	1.0	-3.4	-3.3	-3.7	-1.9
Length of working week for main job	0.1	0.1	0.3	0.5	0.5	-0.1	-0.1	0.2	0.2	0.3	0.2
Exposure to tobacco smoke at home	0.8	0.8	2.9	-0.6	0.9	-0.4	-1.7	-0.9	-1.0	-0.1	-0.8
Breastfed as a baby	0.8	1.0	2.7	1.2	0.5	0.9	0.2	1.0	1.0	0.8	1.7
Tense / ‘highly strung’	1.6	2.7	6.0	1.4	-2.4	1.0	2.2	1.2	1.4	0.4	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.8	-0.1	-0.9	-0.8	0.7	-0.6	-0.4	-0.8	0.6
Hair/balding pattern: Pattern 4	0.1	0.3	0.9	0.5	-0.5	0.5	-0.6	0.3	0.4	0.6	0.9
Birth weight of first child	5.5	10.0	19.8	-3.2	1.7	-4.5	2.6	-3.3	-3.0	-4.0	-2.0
Peak expiratory flow (PEF)	0.5	1.3	2.8	1.0	1.4	1.2	-0.8	0.8	0.8	1.0	1.7
Pulse wave reflection index	0.1	0.1	0.4	-0.0	0.0	0.4	-0.6	0.1	-0.0	0.3	0.0
Ever highly irritable/argumentative for 2 days	5.4	6.5	11.6	-2.7	-1.4	-3.2	2.0	-2.7	-2.6	-3.4	-1.3
Loud music exposure frequency	0.8	0.9	2.3	-1.5	-0.7	-0.4	0.2	-0.8	-0.9	-1.1	-1.2
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.0	0.7	0.4	1.2	0.7	1.2	1.2	0.7	1.7
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	3.9	1.5	0.3	2.0	-0.8	1.6	1.6	1.8	1.2
Blood clot in the leg (DVT)	3.1	4.0	7.4	2.7	-0.9	2.1	-1.9	1.6	1.7	2.4	2.1
Medication: Paracetamol	0.5	0.9	2.5	-1.6	1.5	-0.2	-0.4	-0.6	-0.8	-0.7	-0.6
Headache pain in last month	4.2	7.1	13.9	-3.7	0.7	-3.0	2.2	-2.7	-2.6	-3.7	-0.9
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	4.4	-1.3	-1.4	-1.9	2.1	-1.2	-1.2	-1.8	-1.5
Glaucoma (self-reported)	0.4	0.4	0.6	-0.8	-0.1	-0.8	-0.5	-0.8	-0.8	-0.5	-0.8
Gout (self-reported)	4.6	6.3	10.0	3.1	-0.5	2.9	-1.6	2.6	2.6	3.2	2.4
Hypothyroidism/myxoedema (self-reported)	17.1	33.3	65.9	6.0	-3.2	8.1	-4.0	6.1	5.8	7.5	3.5
Medication: Amlodipine	0.7	1.0	1.7	1.0	0.7	1.3	-0.7	1.0	1.0	1.3	0.6
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.6	-0.1	0.6	-0.1	0.8	0.1	0.0	-0.2	-0.3
Birth weight	3.3	7.1	20.2	-2.3	-0.2	-3.2	4.5	-1.7	-1.6	-3.4	-2.1
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.5	0.5	-0.6	0.7	-0.1	0.6	0.5	0.6	-0.4
High blood pressure (siblings)	2.4	3.4	7.0	1.5	0.2	2.6	-1.8	1.9	1.7	2.2	1.9
Forced vital capacity (FVC), Best measure	0.6	2.4	6.2	1.6	-0.9	1.6	0.8	1.5	1.7	1.1	2.5
Body fat percentage	0.9	3.4	5.9	-2.3	0.4	-2.3	-0.3	-2.4	-2.3	-2.3	-0.2
Leg fat percentage (right)	1.4	4.9	8.2	-2.7	0.6	-2.9	0.4	-2.7	-2.6	-2.9	-0.7
Arm fat-free mass (right)	2.0	10.4	21.8	-3.3	2.4	-4.7	1.0	-3.8	-3.5	-3.9	-1.3
Exposure to tobacco smoke outside home	1.7	2.2	3.4	1.6	-1.0	1.8	0.7	1.8	1.8	1.4	1.5
Comparative body size at age 10	0.9	2.5	7.5	1.6	2.7	1.1	-1.5	1.2	1.2	1.8	0.9
Number of full brothers	5.1	6.4	10.0	-3.0	-0.6	-3.2	0.0	-3.2	-3.1	-3.2	-1.6
Worry too long after embarrassment	0.3	0.4	1.3	0.2	-1.2	0.0	1.1	0.2	0.2	-0.1	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.0	1.0	-1.0	0.7	0.7	1.0	1.0	0.7	0.2
Wheeze or whistling in the chest in last year	0.6	1.0	3.1	-0.4	1.8	-0.7	-1.7	-0.9	-0.9	-0.1	-0.1
Number of children fathered	0.7	0.8	1.3	-0.9	0.9	-1.0	-0.2	-1.1	-1.1	-1.1	0.2
Reason for reducing amount of alcohol drunk: Health precaution	3.5	4.0	6.3	2.3	0.5	2.5	-0.0	2.5	2.5	2.4	1.7
Age at first live birth	0.4	0.7	1.8	0.6	1.2	0.7	-0.5	0.6	0.7	0.7	1.3
Pulse wave peak to peak time	2.9	3.4	6.6	2.5	0.1	0.9	2.6	1.8	2.1	0.9	2.4
Health satisfaction	0.6	0.8	2.4	-0.5	-1.6	-0.2	1.4	-0.2	-0.2	-0.9	1.0
Shortness of breath walking on level ground	0.4	0.4	1.8	0.0	-1.4	-0.1	1.0	0.0	0.1	-0.4	0.7
Qualifications: College or University degree	1.1	3.3	7.0	1.8	0.8	1.9	0.9	2.1	2.1	1.5	2.6
Eye problems/disorders: None of the above	0.5	0.5	1.2	0.7	1.1	0.5	0.2	0.8	0.9	0.7	0.6
Mouth/teeth dental problems: Loose teeth	3.4	4.0	6.0	-2.0	-1.8	-2.4	0.6	-2.4	-2.3	-2.4	-1.4
Emphysema/chronic bronchitis	0.3	0.4	0.7	-0.8	-0.8	-0.6	-0.1	-0.5	-0.6	-0.5	-0.7
Medication for pain relief, constipation, heartburn	1.3	2.3	5.5	-0.7	-1.3	-2.3	0.3	-1.8	-1.6	-1.5	-1.5
Neck or shoulder pain in last month	4.2	6.0	11.3	-3.4	-0.1	-2.6	0.5	-2.6	-2.7	-2.8	-2.8
Medication: Blood pressure	3.5	6.2	11.6	2.3	1.6	3.0	-3.4	1.9	1.8	3.1	2.2
Angina (self-reported)	0.4	0.5	2.3	-0.0	0.1	0.9	-1.5	0.0	-0.0	0.6	0.9
Migraine (self-reported)	2.5	3.1	4.3	-2.0	-1.5	-1.9	2.0	-1.4	-1.4	-2.1	-1.8
Medication: Ibuprofen	1.6	1.9	4.1	-1.6	0.3	-1.4	2.0	-1.1	-1.0	-1.9	-0.9
Medication: Allopurinol	4.0	5.3	9.4	2.7	0.1	2.7	-2.3	2.2	2.2	3.1	2.1
Medication: Omeprazole	0.9	1.1	2.7	1.0	-0.2	1.4	-0.7	0.9	0.9	1.1	1.6
Medication: Seretide 50 evohaler	0.2	0.3	0.6	0.2	0.6	0.6	-0.7	0.4	0.3	0.6	-0.1
Mean time to correctly identify matches	7.1	13.6	24.9	3.9	-0.1	4.9	-3.3	3.9	3.7	5.0	2.0
Heart disease (mother)	5.1	6.2	13.2	2.6	1.5	2.8	-3.6	1.9	1.9	3.4	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.6	0.4	1.9	0.6	-1.7	0.4	0.4	0.9	1.2
Whole body fat mass	1.5	6.4	11.6	-3.0	0.9	-3.4	0.4	-3.2	-3.0	-3.3	-0.5
Leg fat mass (right)	1.7	6.6	12.5	-2.9	1.2	-3.5	0.7	-3.1	-3.0	-3.3	-0.4
Arm predicted mass (right)	2.0	10.0	20.6	-3.2	2.6	-4.5	0.9	-3.7	-3.4	-3.8	-1.3
Pulse rate, automated reading	0.4	1.4	2.7	0.9	-0.5	1.6	-0.3	1.4	1.3	1.2	1.6
Alcohol intake frequency.	0.3	0.6	1.2	0.7	0.1	1.1	-0.6	0.9	0.8	1.0	0.5
Comparative height size at age 10	1.8	9.8	19.3	-3.0	0.3	-4.4	2.3	-3.6	-3.3	-4.3	-1.5
Number of full sisters	0.1	0.2	0.6	-0.4	0.3	-0.2	0.8	0.1	0.0	-0.4	0.4
Suffer from ‘nerves’	1.8	2.9	5.9	-1.7	-2.1	-1.5	2.4	-1.2	-1.1	-2.2	-0.5
Overall health rating	0.7	1.4	2.5	-1.3	-1.2	-1.2	-0.1	-1.6	-1.5	-1.4	-0.3
Chest pain or discomfort	0.3	0.4	1.5	-0.7	-0.8	-0.0	1.2	-0.1	-0.2	-0.7	0.2
Had major operations	0.5	0.6	1.3	0.2	-0.5	1.0	-1.1	0.6	0.5	0.8	0.7
Age at last live birth	0.2	0.3	1.0	0.4	0.4	0.5	-1.0	0.3	0.3	0.6	0.7
Family relationship satisfaction	0.1	0.1	0.3	0.2	0.0	0.2	0.5	0.3	0.4	0.1	0.5
Leg pain on walking	0.8	1.0	2.1	-1.4	0.1	-1.1	0.6	-1.0	-1.0	-1.4	0.4
Qualifications: NVQ or HND or HNC or equivalent	7.4	9.0	13.9	-3.1	-2.5	-3.2	3.2	-2.7	-2.6	-3.7	-2.5
Commuting to job workplace: Car/motor vehicle	1.7	2.0	3.4	-1.4	0.6	-1.4	-1.2	-1.7	-1.7	-1.1	-1.8
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	-0.3	0.2	-0.8	-0.3	-0.6	-0.6	-0.4	-0.9
Medication: Aspirin	2.0	2.6	5.1	1.5	0.6	2.2	-1.4	1.6	1.6	2.0	1.5
Supplements: Vitamin C	0.3	0.4	1.0	0.4	0.4	0.5	0.4	0.8	0.8	0.5	1.0
Knee pain experienced in last month	5.7	8.9	13.5	-3.7	0.4	-3.5	0.2	-3.5	-3.5	-3.4	-3.0
Hypertension (Self-reported)	4.5	12.4	23.4	3.2	2.2	4.3	-4.8	2.8	2.6	4.6	2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	4.6	1.6	-1.4	2.1	-0.0	1.9	1.8	1.8	1.2
Illnesses of father: Heart disease	1.6	2.2	6.5	1.1	0.9	1.8	-2.5	0.8	0.8	1.7	1.3
Illnesses of siblings: Diabetes	1.2	1.4	5.3	-0.7	1.7	-0.3	-2.3	-1.1	-1.1	-0.2	0.6
Smoking status: Previous	4.1	6.1	17.0	2.3	0.6	2.8	-4.1	1.7	1.6	3.4	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.4	-0.1	0.6	-0.4	0.6	-0.4	-0.2	-0.5	0.5
Whole body fat-free mass	1.5	8.4	17.9	-2.9	2.4	-4.2	1.5	-3.2	-3.0	-3.7	-0.8
Leg fat-free mass (right)	0.7	3.5	7.8	-1.5	2.3	-2.8	1.1	-1.9	-1.7	-2.3	0.5
Arm fat percentage (left)	0.4	1.5	2.7	-1.4	-0.2	-1.6	0.2	-1.6	-1.5	-1.6	0.4
Average weekly red wine intake	0.2	0.3	1.0	-0.4	-0.7	-0.2	1.0	0.1	0.1	-0.4	0.4
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.6	-0.7	-0.5	-0.5	0.5	-0.3	-0.4	-0.5	-1.3
Mood swings	3.1	5.5	9.7	-2.5	-1.9	-2.6	2.9	-1.9	-1.8	-3.1	-1.6
Loneliness, isolation	4.5	6.2	10.9	-2.6	-1.2	-3.3	1.9	-2.7	-2.6	-3.3	-1.6
Long-standing illness, disability or infirmity	0.7	1.0	7.2	0.5	-2.7	0.5	-0.1	0.1	0.2	0.2	0.4
Ever had bowel cancer screening	1.2	1.4	2.5	1.3	-1.0	1.2	0.7	1.6	1.5	1.2	0.2
Diabetes diagnosed by doctor	0.5	0.9	2.3	0.6	-0.2	1.5	-1.2	0.8	0.7	1.3	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	0.3	-0.3	0.2	0.9	0.3	0.4	0.0	0.6
Friendships satisfaction	1.6	2.0	4.0	1.5	0.5	1.3	1.1	1.6	1.7	1.0	2.0
Qualifications: nursing, teaching	0.2	0.3	0.5	0.7	0.1	0.5	0.3	0.7	0.7	0.6	0.4
Commuting to job workplace: Walk	0.2	0.2	0.7	-0.2	0.6	-0.2	-0.5	-0.2	-0.2	-0.2	0.9
Eye problems/disorders: Cataract	0.9	1.0	1.9	-1.4	-0.5	-0.8	0.3	-1.0	-1.1	-1.1	-1.3
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	3.8	-1.9	0.4	-1.9	0.1	-1.7	-1.7	-1.7	-1.6
Medication for cholesterol	2.7	4.0	8.9	-1.7	0.4	-3.0	1.5	-2.4	-2.1	-2.8	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.5	-0.7	0.6	-0.3	-0.5	-0.4	-0.5	-0.3	-1.2
Back pain experienced in last month	2.5	3.7	7.5	-1.7	-0.9	-2.5	2.2	-2.0	-1.7	-2.7	-0.4
Mineral and other dietary supplements	0.2	0.3	1.0	0.3	-1.0	0.0	0.2	0.0	0.1	-0.1	1.0
Breast cancer (self-reported)	0.3	0.4	0.7	-0.7	0.5	-0.8	-0.3	-0.8	-0.8	-0.7	-0.2
Asthma (self-reported)	0.4	0.9	1.5	1.2	0.2	0.5	1.0	1.0	1.1	0.7	1.1
Osteoporosis (self-reported)	0.3	0.4	1.3	-0.0	-0.2	1.1	-0.2	0.8	0.6	0.7	-0.5
Osteoarthritis (self-reported)	0.4	0.6	1.3	-0.6	1.1	-0.2	-1.1	-0.4	-0.6	0.0	-1.1
Medication: Aspirin	1.0	1.3	2.7	1.0	0.3	1.6	-1.1	1.0	1.0	1.4	0.9
Medication: Gliclazide	0.3	0.3	0.5	0.5	0.1	0.7	-0.6	0.5	0.5	0.7	0.7
Illnesses of father: None of the above (group 1)	2.0	2.5	10.4	-1.0	-1.5	-1.4	3.2	-0.6	-0.4	-2.0	-0.0
Smoking status: Current	9.6	15.3	22.9	-4.4	-0.4	-4.8	0.6	-4.8	-4.7	-4.6	-3.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.5	0.9	-1.1	1.1	0.7	1.2	1.2	0.8	1.2
Whole body water mass	1.5	8.8	18.8	-3.0	2.3	-4.3	1.5	-3.3	-3.1	-3.7	-0.8
Leg predicted mass (right)	0.6	3.3	7.3	-1.5	2.3	-2.7	1.0	-1.8	-1.6	-2.2	0.5
Arm fat mass (left)	1.0	4.1	8.2	-2.3	1.0	-2.9	0.2	-2.5	-2.4	-2.5	-0.2
Number of self-reported non-cancer illnesses	3.7	6.4	11.8	2.7	0.3	3.3	-2.3	2.6	2.5	3.4	1.7
Average weekly champagne plus white wine intake	0.2	0.3	1.5	-0.2	0.2	0.3	-1.2	-0.2	-0.3	0.3	-0.4
Miserableness	0.7	1.2	2.5	-0.9	-1.2	-1.2	1.6	-0.8	-0.7	-1.5	-0.3
Guilty feelings	1.3	1.9	8.2	-0.8	-2.9	-0.8	1.9	-0.4	-0.4	-1.1	-0.7
Wears glasses or contact lenses	0.3	0.3	1.6	-0.0	1.3	0.4	-0.6	0.3	0.3	0.3	0.6
Ever taken oral contraceptive pill	5.7	6.4	10.1	-2.7	2.3	-2.6	-2.0	-3.2	-3.2	-2.2	-1.6
Hearing aid user	0.8	0.8	3.0	-0.4	0.2	-0.3	-1.5	-0.8	-0.9	-0.0	-1.7
Mother’s age at death	0.2	0.3	0.8	-0.3	-0.3	-0.9	0.2	-0.6	-0.5	-0.6	-0.7
Financial situation satisfaction	0.3	0.4	1.0	-1.0	-0.3	-0.3	0.9	-0.5	-0.5	-0.9	-0.3
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.6	0.6	-1.3	0.4	0.3	0.3	0.3	0.4	-1.1
Commuting to job workplace: Public transport	0.7	0.9	1.8	1.0	-0.5	1.0	-0.3	0.9	1.0	1.0	1.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.4	-0.1	-0.7	-0.3	-0.2	-0.2	-0.2	-0.0	-0.7
Medication: Blood pressure	5.4	10.3	19.6	3.3	-0.0	4.4	-2.8	3.5	3.3	4.4	1.6
Pain type(s) experienced in last month: Hip pain	1.3	1.6	2.4	-1.4	0.2	-1.6	0.1	-1.5	-1.5	-1.4	-1.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.8	-0.3	-0.1	-0.0	0.3	0.1	0.0	-0.0	-0.9
High cholesterol (Self-reported)	1.1	1.9	5.7	0.6	2.4	1.2	-2.0	0.9	0.7	1.5	0.1
Medication: Bendroflumethiazide	2.1	3.3	8.4	1.3	1.5	2.2	-2.9	1.3	1.2	2.4	0.3
Medication: Paracetamol	0.4	0.6	2.2	-1.5	0.1	-0.2	0.5	-0.5	-0.7	-0.9	-0.8
Medication: Lisinopril	2.8	3.6	6.0	2.0	-0.4	2.5	-0.7	2.1	2.1	2.2	2.1
Medication: Atorvastatin	0.1	0.2	0.4	-0.3	0.7	-0.2	-0.3	-0.4	-0.4	-0.2	-0.5
Illnesses of father: High blood pressure	1.6	1.9	3.6	1.3	0.4	1.9	-1.0	1.6	1.4	1.7	1.2
Alcohol drinker status: Never	0.5	0.6	1.7	-1.3	0.2	-0.8	0.0	-0.9	-0.9	-1.0	-0.0
Ever smoked	1.9	3.3	10.6	1.6	0.5	2.0	-3.2	0.9	0.9	2.4	1.2
Basal metabolic rate	1.7	9.5	19.6	-3.2	2.4	-4.4	1.4	-3.5	-3.2	-3.9	-0.8
Leg fat percentage (left)	1.1	4.0	6.9	-2.3	1.1	-2.6	-0.1	-2.5	-2.4	-2.4	-0.6
Arm fat-free mass (left)	2.3	11.8	23.7	-3.6	2.9	-4.9	1.2	-3.9	-3.7	-4.2	-1.1
Number of operations (self-reported)	0.1	0.2	0.6	-0.7	0.2	0.2	-0.8	0.0	-0.1	-0.0	0.7
Average weekly beer plus cider intake	0.7	0.9	4.1	-0.6	-0.9	-0.9	2.0	-0.3	-0.3	-1.1	-0.3
Irritability	0.6	1.1	2.7	-0.8	-1.7	-0.7	0.8	-0.8	-0.7	-1.0	-1.3
Risk taking	1.0	1.5	3.3	-1.2	-1.0	-1.3	1.8	-1.0	-0.9	-1.6	-0.5
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.1	0.5	1.4	1.0	0.1	1.1	1.0	0.7	1.1
Fractured/broken bones in last 5 years	0.5	0.6	3.2	-0.1	0.9	0.6	-1.8	-0.1	-0.2	0.6	-0.3
Age started oral contraceptive pill	0.8	0.9	2.1	1.1	0.2	1.0	-1.4	0.8	0.7	1.4	-0.1
Diastolic blood pressure, automated reading	6.7	20.7	38.7	4.6	0.6	6.2	-4.5	4.4	4.2	5.9	3.7
Ever depressed for a whole week	2.2	2.8	4.5	-2.1	-0.6	-1.9	0.4	-1.9	-1.9	-2.1	-1.4
Unable to work because of sickness or disability	2.2	2.8	6.9	1.5	-2.5	1.2	1.1	1.3	1.5	0.8	2.6
Commuting to job workplace: Cycle	1.3	1.6	4.0	1.1	-0.7	1.1	1.0	1.3	1.4	0.8	2.0
Myopia	0.2	0.3	0.7	0.4	-0.7	0.8	0.0	0.6	0.6	0.5	0.6
Vascular/heart problems diagnosed by doctor	4.3	11.7	23.2	-3.0	-1.8	-4.4	4.8	-2.8	-2.5	-4.6	-1.9
Cholesterol lowering medication	0.8	1.2	5.4	-0.3	0.8	0.9	-2.3	0.2	-0.0	1.0	-1.1
Medication: Omeprazole (e.g. Zanprol)	2.8	3.4	6.6	1.8	-0.5	2.6	-0.8	1.9	1.9	2.1	2.2
Pain experienced in last month	5.8	9.7	17.0	4.0	-0.3	3.7	-2.1	3.3	3.3	4.1	2.3
Supplements: Calcium	2.1	2.3	4.0	1.7	0.4	2.0	-0.7	1.9	1.8	2.0	0.7
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	0.0	-0.4	0.1	0.4	0.3	0.2	0.1	-0.6
Heart attack/myocardial infarction (self-reported)	1.1	1.5	7.7	0.1	0.8	1.3	-2.8	0.2	0.1	1.2	-0.3
Deep venous thrombosis (DVT) (self-reported)	3.1	3.9	7.6	2.8	-1.0	2.1	-1.6	1.6	1.8	2.3	2.3
Heart disease (siblings)	0.3	0.4	2.5	-0.2	-0.1	-0.2	-1.6	-0.6	-0.6	0.0	0.1
Alcohol drinker status: Previous	3.1	3.6	6.1	2.5	0.6	2.1	-0.2	1.9	2.0	2.0	2.4
Pack years of smoking	0.9	1.4	3.8	-1.1	-0.3	-1.4	1.9	-0.8	-0.7	-1.6	0.1
Impedance of whole body	0.3	1.3	4.1	0.3	-2.0	1.7	-1.3	0.5	0.4	1.0	-0.5
Leg fat mass (left)	1.6	6.2	11.8	-2.7	1.6	-3.4	0.3	-3.1	-2.9	-3.1	-0.5
Arm predicted mass (left)	2.4	12.4	24.6	-3.7	2.9	-5.0	1.2	-4.0	-3.8	-4.3	-1.1