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chr17:34,146,026-35,675,511

Best TWAS P=5.79e-09 · Best GWAS P=2.92e-08 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNHIT3	0.05	0.03	enet	4	0.04	4.7e-05	5.5	5.8	5.8e-09	0.97	0.00	1.00	TRUE
21	GTEx	Esophagus Mucosa	DHRS11	0.12	0.08	lasso	2	0.06	5.1e-05	5.5	5.7	1.2e-08	0.97	0.02	0.98	FALSE
29	GTEx	Thyroid	GGNBP2	0.07	0.06	lasso	2	0.04	2.8e-04	-5.5	-5.6	1.7e-08	-0.82	0.02	0.98	FALSE
42	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZNHIT3	0.03	0.03	enet	4	0.03	1.8e-04	-5.4	5.6	2.1e-08	0.83	0.01	0.95	FALSE
5	GTEx	Artery Aorta	DHRS11	0.10	0.07	lasso	5	0.06	2.7e-04	-5.5	5.5	3.1e-08	0.79	0.02	0.97	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GGNBP2	0.04	0.04	enet	3	0.04	6.3e-05	4.9	-5.5	3.1e-08	-0.90	0.01	0.99	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	GGNBP2	0.12	0.12	lasso	2	0.09	4.9e-04	-5.5	-5.5	3.2e-08	-0.77	0.02	0.95	FALSE
20	GTEx	Esophagus Mucosa	GGNBP2	0.16	0.16	enet	15	0.18	3.1e-12	-4.5	-5.5	3.3e-08	-0.88	0.06	0.94	FALSE
25	GTEx	Lung	GGNBP2	0.08	0.01	enet	8	0.01	3.3e-02	5.5	-5.5	3.8e-08	-0.93	0.02	0.98	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DHRS11	0.04	0.04	lasso	2	0.04	3.1e-05	-5.5	5.5	3.8e-08	0.78	0.00	0.99	FALSE
14	GTEx	Breast Mammary Tissue	GGNBP2	0.08	0.06	lasso	2	0.03	7.8e-03	-4.6	-5.5	3.9e-08	-0.73	0.03	0.83	FALSE
10	GTEx	Brain Cerebellum	DHRS11	0.33	0.23	lasso	4	0.20	1.9e-06	-5.5	5.5	4.0e-08	0.77	0.01	0.98	FALSE
34	The Cancer Genome Atlas	Colon Adenocarcinoma	MRM1	0.06	0.06	enet	4	0.05	9.4e-04	-5.5	-5.5	4.7e-08	-0.78	0.00	0.94	FALSE
7	GTEx	Artery Tibial	MYO19	0.12	0.11	lasso	6	0.13	4.1e-10	5.1	5.5	4.9e-08	0.93	0.05	0.95	FALSE
18	GTEx	Colon Transverse	MYO19	0.13	0.12	lasso	2	0.11	8.0e-06	5.5	5.4	5.1e-08	0.98	0.02	0.97	FALSE
6	GTEx	Artery Tibial	GGNBP2	0.12	0.12	enet	15	0.12	1.2e-09	-5.5	-5.4	6.3e-08	-0.85	0.02	0.98	FALSE
22	GTEx	Esophagus Muscularis	DHRS11	0.14	0.08	lasso	5	0.08	8.2e-06	-5.1	5.4	7.1e-08	0.94	0.03	0.97	FALSE
1	GTEx	Adipose Subcutaneous	GGNBP2	0.10	0.11	enet	9	0.11	3.5e-09	4.9	-5.4	7.3e-08	-0.92	0.06	0.94	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	DHRS11	0.05	0.11	enet	6	0.10	7.4e-12	-5.1	5.4	7.3e-08	0.81	0.00	1.00	FALSE
4	GTEx	Artery Aorta	GGNBP2	0.13	0.12	lasso	4	0.12	2.4e-07	-5.5	-5.4	8.1e-08	-0.82	0.02	0.98	FALSE
8	GTEx	Brain Caudate basal ganglia	DHRS11	0.18	0.12	lasso	4	0.02	9.2e-02	-5.1	5.4	8.3e-08	0.79	0.02	0.85	FALSE
26	GTEx	Lung	DHRS11	0.09	0.08	lasso	5	0.10	3.7e-08	-5.1	5.3	9.0e-08	0.86	0.02	0.98	FALSE
11	GTEx	Brain Cortex	DHRS11	0.23	0.18	enet	24	0.18	8.5e-06	-5.5	5.3	9.2e-08	0.76	0.02	0.98	FALSE
32	NTR	Blood	GGNBP2	0.03	0.02	bslmm	331	0.02	7.7e-07	-4.5	-5.3	9.4e-08	-0.79	0.06	0.94	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	GGNBP2	0.13	0.15	lasso	2	0.13	5.5e-05	-5.3	-5.3	1.2e-07	-0.84	0.02	0.94	FALSE
36	The Cancer Genome Atlas	Esophageal Carcinoma	ZNHIT3	0.11	0.11	lasso	4	0.09	6.2e-04	-5.4	5.3	1.2e-07	0.78	0.01	0.80	FALSE
3	GTEx	Adipose Visceral Omentum	GGNBP2	0.13	0.12	enet	11	0.13	1.9e-07	-4.8	-5.3	1.3e-07	-0.80	0.06	0.93	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	DHRS11	0.14	0.08	enet	3	0.07	3.2e-03	-5.3	5.3	1.3e-07	0.84	0.03	0.85	FALSE
44	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DHRS11	0.06	0.06	blup	12	0.04	2.0e-02	-5.1	5.3	1.3e-07	0.68	0.00	0.66	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	GGNBP2	0.04	0.04	enet	6	0.05	1.4e-05	-5.1	-5.3	1.3e-07	-0.88	0.01	0.98	FALSE
23	GTEx	Esophagus Muscularis	MYO19	0.14	0.14	enet	8	0.15	2.8e-09	5.5	5.3	1.4e-07	0.97	0.03	0.97	FALSE
28	GTEx	Nerve Tibial	GGNBP2	0.10	0.04	lasso	3	0.05	2.4e-04	4.9	-5.3	1.4e-07	-0.92	0.04	0.96	FALSE
2	GTEx	Adipose Subcutaneous	MYO19	0.07	0.05	enet	10	0.03	1.3e-03	5.1	5.2	1.6e-07	0.94	0.04	0.96	FALSE
9	GTEx	Brain Cerebellar Hemisphere	CTB-75G16.3	0.27	0.14	lasso	4	0.05	1.8e-02	-5.4	-5.2	1.6e-07	-0.73	0.02	0.80	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	ZNHIT3	0.31	0.32	enet	9	0.22	1.1e-07	5.1	5.2	1.7e-07	0.92	0.07	0.92	FALSE
33	YFS	Blood	DHRS11	0.05	0.06	lasso	7	0.06	2.5e-18	-4.8	5.2	1.8e-07	0.80	0.26	0.74	FALSE
30	METSIM	Adipose	GGNBP2	0.16	0.14	lasso	5	0.14	6.2e-21	5.1	-5.2	1.9e-07	-0.92	0.11	0.89	FALSE
24	GTEx	Heart Left Ventricle	MYO19	0.10	0.06	lasso	3	0.04	5.4e-03	5.5	5.2	2.0e-07	0.96	0.02	0.93	FALSE
27	GTEx	Muscle Skeletal	DHRS11	0.09	0.08	lasso	3	0.09	9.3e-09	-5.1	5.2	2.0e-07	0.82	0.03	0.97	FALSE
43	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZNHIT3	0.06	0.03	enet	2	0.04	1.3e-03	-5.1	5.2	2.0e-07	0.85	0.01	0.93	FALSE
13	GTEx	Brain Nucleus accumbens basal ganglia	DHRS11	0.18	0.20	lasso	3	0.15	8.8e-05	-5.2	5.2	2.1e-07	0.77	0.02	0.95	FALSE
31	METSIM	Adipose	MYO19	0.10	0.10	lasso	4	0.10	1.6e-14	5.1	5.2	2.1e-07	0.92	0.11	0.88	FALSE
41	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	GGNBP2	0.05	0.04	lasso	2	0.01	8.1e-02	-5.1	-5.2	2.1e-07	-0.80	0.01	0.80	FALSE
35	The Cancer Genome Atlas	Esophageal Carcinoma	DHRS11	0.12	0.12	blup	13	0.12	1.5e-04	-5.5	5.2	2.5e-07	0.59	0.00	0.94	FALSE
12	GTEx	Brain Hypothalamus	DHRS11	0.24	0.12	lasso	2	0.12	1.1e-03	-5.3	5.1	2.6e-07	0.84	0.03	0.89	FALSE