Best TWAS P=2.59e-09 · Best GWAS P=2.52e-09 conditioned to 1.88e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FAM86B1 | 0.02 | 0.02 | lasso | 3 | 0.01 | 1.3e-02 | 4.9 | 5.5 | 4.0e-08 | 0.35 | 0.02 | 0.94 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | FAM90A25P | 0.11 | 0.08 | lasso | 3 | 0.08 | 1.4e-09 | 5.0 | 5.3 | 9.0e-08 | 0.27 | 0.00 | 1.00 | FALSE |
3 | GTEx | Adipose Visceral Omentum | AF131215.9 | 0.18 | 0.16 | lasso | 7 | 0.16 | 2.0e-08 | 4.8 | 5.2 | 1.9e-07 | 0.41 | 0.50 | 0.50 | FALSE |
4 | GTEx | Adrenal Gland | FAM86B3P | 0.16 | 0.00 | enet | 18 | 0.03 | 2.2e-02 | 4.3 | -5.2 | 2.5e-07 | -0.18 | 0.04 | 0.09 | FALSE |
5 | GTEx | Adrenal Gland | AF131215.2 | 0.20 | 0.16 | enet | 12 | 0.13 | 2.2e-05 | 4.9 | 5.3 | 1.4e-07 | 0.41 | 0.46 | 0.53 | FALSE |
6 | GTEx | Adrenal Gland | AF131215.9 | 0.18 | 0.16 | lasso | 10 | 0.18 | 3.5e-07 | 4.9 | 5.3 | 1.1e-07 | 0.41 | 0.47 | 0.51 | FALSE |
7 | GTEx | Artery Aorta | AF131215.2 | 0.09 | 0.09 | lasso | 7 | 0.08 | 2.0e-05 | -5.0 | 5.4 | 6.2e-08 | 0.44 | 0.46 | 0.50 | FALSE |
8 | GTEx | Artery Aorta | AF131215.9 | 0.13 | 0.05 | lasso | 6 | 0.07 | 1.3e-04 | 5.1 | 5.4 | 7.8e-08 | 0.41 | 0.39 | 0.59 | FALSE |
9 | GTEx | Breast Mammary Tissue | AF131215.2 | 0.16 | 0.15 | lasso | 6 | 0.12 | 1.1e-06 | -5.0 | 5.1 | 2.9e-07 | 0.45 | 0.47 | 0.50 | FALSE |
10 | GTEx | Breast Mammary Tissue (Female) | AF131215.9 | 0.04 | -0.01 | enet | 6 | 0.02 | 7.3e-02 | -4.5 | 5.2 | 2.2e-07 | 0.39 | 0.08 | 0.17 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | ERI1 | 0.34 | 0.35 | lasso | 7 | 0.35 | 1.9e-27 | 4.9 | -5.4 | 8.0e-08 | -0.29 | 0.03 | 0.97 | FALSE |
12 | GTEx | Esophagus Mucosa | AF131215.9 | 0.18 | 0.16 | lasso | 14 | 0.19 | 1.6e-12 | 4.4 | 5.2 | 1.6e-07 | 0.44 | 0.49 | 0.50 | FALSE |
13 | GTEx | Esophagus Muscularis | AF131215.9 | 0.14 | 0.17 | enet | 16 | 0.17 | 1.6e-10 | -4.6 | 5.4 | 7.7e-08 | 0.42 | 0.76 | 0.23 | FALSE |
14 | GTEx | Heart Left Ventricle | AF131215.2 | 0.05 | 0.01 | enet | 11 | 0.01 | 1.5e-01 | 4.7 | 5.4 | 7.7e-08 | 0.41 | 0.32 | 0.31 | FALSE |
15 | GTEx | Heart Left Ventricle | AF131215.9 | 0.07 | 0.10 | enet | 8 | 0.10 | 9.4e-06 | -4.6 | 5.1 | 2.7e-07 | 0.40 | 0.61 | 0.31 | FALSE |
16 | GTEx | Nerve Tibial | AF131215.2 | 0.19 | 0.18 | lasso | 12 | 0.23 | 3.5e-16 | -4.6 | 5.2 | 1.7e-07 | 0.43 | 0.62 | 0.38 | FALSE |
17 | GTEx | Pancreas | AF131215.2 | 0.16 | 0.16 | enet | 17 | 0.15 | 9.1e-07 | -4.6 | 5.2 | 2.3e-07 | 0.42 | 0.55 | 0.44 | FALSE |
18 | GTEx | Pancreas | AF131215.9 | 0.25 | 0.24 | enet | 14 | 0.22 | 1.0e-09 | 5.1 | 5.3 | 9.5e-08 | 0.41 | 0.36 | 0.64 | FALSE |
19 | GTEx | Skin Sun Exposed Lower leg | FAM85A | 0.09 | 0.04 | enet | 28 | 0.04 | 1.4e-04 | -4.8 | 5.3 | 1.2e-07 | 0.17 | 0.03 | 0.94 | FALSE |
20 | GTEx | Skin Sun Exposed Lower leg | AF131215.9 | 0.19 | 0.17 | enet | 29 | 0.21 | 3.9e-17 | -4.6 | 5.6 | 2.6e-08 | 0.40 | 0.81 | 0.19 | FALSE |
21 | GTEx | Testis | AF131215.2 | 0.28 | 0.18 | enet | 41 | 0.17 | 8.0e-08 | -4.5 | 5.3 | 1.4e-07 | 0.54 | 0.74 | 0.25 | FALSE |
22 | GTEx | Thyroid | AF131215.2 | 0.11 | 0.15 | enet | 17 | 0.18 | 1.2e-13 | -4.5 | 5.3 | 1.2e-07 | 0.42 | 0.82 | 0.18 | FALSE |
23 | NTR | Blood | MSRA | 0.02 | 0.01 | blup | 833 | 0.01 | 2.3e-05 | 3.6 | -5.9 | 3.9e-09 | -0.34 | 0.44 | 0.55 | FALSE |
24 | NTR | Blood | PPP1R3B | 0.03 | 0.02 | enet | 11 | 0.02 | 1.5e-07 | 4.5 | 5.4 | 7.6e-08 | 0.28 | 0.13 | 0.85 | FALSE |
25 | ROSMAP | Brain Pre-frontal Cortex | XKR6 | 0.11 | 0.10 | enet | 23 | 0.13 | 1.2e-16 | -4.1 | 5.5 | 4.3e-08 | 0.44 | 0.83 | 0.17 | FALSE |
26 | ROSMAP | Brain Pre-frontal Cortex | AF131215.3 | 0.08 | 0.10 | lasso | 7 | 0.12 | 8.3e-16 | 5.0 | 5.2 | 2.1e-07 | 0.39 | 0.44 | 0.55 | FALSE |
27 | ROSMAP | Brain Pre-frontal Cortex | RP11-481A20.11 | 0.06 | 0.04 | blup | 286 | 0.04 | 2.2e-06 | 5.0 | 6.0 | 2.6e-09 | 0.32 | 0.04 | 0.96 | TRUE |