Hub : Genes

OR13E1P

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hypothalamus	0.2870	0.0950	0.0039	0.048	NA	0.027	NA	0.051	0.02800	NA	0.0790	NA	2.5e-02
2	GTEx	Brain Nucleus accumbens basal ganglia	0.2760	0.1050	0.0086	-0.010	NA	-0.009	NA	0.057	0.74000	NA	0.7000	NA	1.3e-02
3	GTEx	Breast Mammary Tissue (Female)	0.0587	0.0517	0.1600	0.049	NA	-0.006	NA	0.012	0.01400	NA	0.5600	NA	1.4e-01
4	GTEx	Heart Left Ventricle	0.1451	0.0635	0.0078	0.061	NA	0.036	NA	0.084	0.00036	NA	0.0052	NA	3.3e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.3	0.5	1.5	-0.5	0.1	1.2	0.3
Bipolar Disorder or Schizophrenia	0.9	2.3	6.8	-2.6	-0.5	0.8	-1.2
Depressed Affect (Nagel 2018)	0.5	1.0	3.8	0.5	-0.1	0.1	1.9
Depression (Nagel 2018)	0.6	1.0	2.7	-0.2	0.6	0.9	1.6
Intelligence (Savage-Jansen 2018)	0.8	2.6	3.8	1.5	0.9	1.9	1.9
Neuroticism (Nagel 2018)	0.6	1.4	3.3	-0.6	0.5	1.2	1.8
Schizophrenia (2018)	1.5	3.1	8.6	-2.9	-0.8	-0.0	-1.8
Schizophrenia vs Biploar Disorder	0.2	0.3	1.0	-0.1	-0.2	-0.0	-1.0
Worry (Nagel 2018)	1.0	2.1	4.6	-2.1	0.2	1.8	0.6
Alzheimer’s Disease (in mother)	1.0	1.2	2.1	1.1	-1.4	1.2	-0.5
Alzheimer’s Disease (in father)	0.9	1.0	2.0	1.4	-0.3	-1.0	0.9
Alzheimer’s Disease (including proxy)	0.5	0.7	1.6	1.3	-0.9	0.6	0.2
Crohns Disease (2017)	0.2	0.4	0.9	0.1	0.7	-1.0	-0.6
Irritable Bowel Disease (IBD)	0.4	1.0	1.3	-1.1	1.1	-0.7	-0.9
Ulcerative Colitis (UC)	0.6	1.2	2.1	-1.4	0.9	-0.7	-1.1
Major Depression (MDD)	0.6	0.7	1.0	-1.0	-0.8	-0.8	0.8
Reaction Time	0.1	0.1	0.3	-0.6	-0.2	-0.4	0.3
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.8	0.2	0.0	1.9	1.2
Breast Cancer	1.0	2.4	4.6	2.1	1.2	-1.1	1.5
Ovarian Cancer	0.5	0.7	2.2	0.1	0.7	-0.1	-1.5
Prostate Cancer	0.3	0.4	1.4	0.1	-1.2	-0.3	0.5
Age at First Birth	0.9	1.3	2.1	-1.1	-0.2	1.5	1.3
Bipolar Disorder (2011)	0.6	0.6	1.0	-1.0	-1.0	-0.1	0.5
Body Mass Index (BMI) (2010)	1.8	2.5	5.2	1.8	0.9	-2.3	1.0
Coronary Artery Disease (CAD)	1.5	1.8	3.1	-1.1	0.4	1.8	-1.7
Crohns Disease (2012)	0.7	1.1	1.9	-1.1	1.1	-1.4	-0.0
Mean Putamen Volume	0.8	0.9	1.9	-1.4	-1.1	-0.4	-0.7
Fasting Glucose	0.3	0.3	0.9	-0.4	0.3	-1.0	-0.4
HbA1C	1.9	2.1	3.5	-1.9	-1.6	0.8	-1.3
HDL Cholesterol	0.1	0.2	0.5	0.7	0.4	-0.3	0.4
LDL Cholesterol	0.8	1.3	4.0	-0.9	0.6	2.0	0.3
Lupus	0.8	1.2	4.5	0.1	0.6	2.1	-0.2
Neuroticism (2016)	1.0	1.4	3.0	-1.7	1.4	0.6	-0.4
Primary Biliary Cirrhosis	0.8	1.1	2.8	-0.6	0.2	1.7	-1.2
Rheumatoid Arthritis	1.1	1.5	2.8	1.7	-0.4	-0.8	1.6
Schizophrenia (2014)	0.8	1.7	3.5	-1.9	-0.2	0.5	-1.8
Triglycerides	0.2	0.3	1.0	-1.0	0.2	0.2	-0.6
Type 2 Diabetes (T2D) (2012)	1.1	1.2	3.3	0.6	-0.4	-1.8	1.1
Ulcerative Colitis	0.9	1.3	4.4	-2.1	0.6	0.4	-0.7
Blood Eosinophil Count	0.2	1.6	5.3	0.4	0.7	-2.3	-0.5
Blood Platelet Count	0.9	10.2	30.9	0.8	1.9	-5.6	2.4
Blood Red Count	0.2	1.5	3.3	-1.8	-0.5	-1.4	0.7
Blood White Count	1.5	11.2	37.5	-0.5	2.4	-6.1	1.2
Heel T-Score	1.0	7.7	30.2	-0.6	0.4	5.5	0.2
BMI	0.5	3.1	10.4	1.1	-0.2	-3.2	1.0
Height	0.7	14.4	44.6	-0.3	-3.0	-6.7	2.0
Waist Hip Ratio (WHR)	1.2	5.5	18.0	-0.5	-0.1	4.2	-1.9
Systolic Blood Pressure	0.4	2.0	4.0	-0.7	-0.1	2.0	1.8
Smoking Status	0.6	1.5	3.5	-0.6	-0.0	1.5	-1.9
Allergy or Eczema	0.5	1.3	3.2	1.8	-0.6	1.3	0.5
Cardiovascular Disease	0.6	2.1	4.7	-0.2	0.2	2.2	1.9
Hypothyroidism (self reported)	0.2	0.5	1.4	1.2	0.2	-0.8	-0.0
Respiratory disease	0.8	1.7	5.8	2.4	0.9	-0.1	0.2
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.0	1.0	-0.2	-1.0	0.1
Lung FEV1/FVC ratio	0.2	0.9	1.3	-0.7	-0.8	1.1	-1.1
Lung FVC	0.1	0.3	0.8	0.0	0.9	-0.3	-0.5
Neuroticism	0.6	1.6	2.4	-1.1	0.7	1.6	1.4
Chronotype (morning person)	0.8	1.9	2.5	-1.6	-1.2	-1.2	-1.5
Hair Pigment	0.0	1.2	2.0	0.0	-1.4	1.0	-1.4
Tanning	0.3	3.1	7.5	-1.1	0.6	1.8	-2.7
Hand grip strength (left)	0.4	1.1	2.8	-0.1	-0.6	1.7	-1.0
Number of treatments/medications taken	0.1	0.2	0.5	0.2	-0.6	0.4	0.7
Average weekly spirits intake	0.2	0.2	0.4	0.2	0.4	0.4	-0.6
Sensitivity / hurt feelings	0.6	1.0	2.2	-1.5	-0.1	0.3	1.3
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.5	-0.6	1.5	1.9	0.9
Hearing difficulty/problems: Yes	1.7	2.7	4.6	2.1	1.9	-1.5	0.1
Relative age of first facial hair	1.3	2.8	4.6	-0.5	-2.1	1.9	-1.5
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	5.6	2.4	0.8	-1.0	1.4
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.7	0.5	-1.2	-1.3	0.2
Ever had hysterectomy (womb removed)	0.5	0.6	1.4	0.2	1.0	-0.1	1.2
Systolic blood pressure, automated reading	0.2	0.4	0.8	-0.4	-0.9	0.4	0.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.2	-0.6	0.3	-0.6
Angina	1.4	1.9	3.2	-0.7	-1.6	1.8	-1.1
Medication for hormone replacement therapy	2.1	2.3	4.9	0.0	2.2	-1.5	1.5
Vitamin and mineral supplements	1.2	1.6	3.3	-1.1	1.8	-0.1	-1.4
Supplements: Zinc	0.4	0.4	1.1	0.1	-0.3	0.5	1.1
Medication: Co-codamol	0.7	0.8	2.1	1.4	-0.5	-0.7	0.4
Medication: Metformin	2.5	3.6	10.1	1.6	-0.5	-3.2	1.1
Diabetes (father)	0.6	0.8	1.6	1.0	-0.3	-0.5	1.3
Diabetes (mother)	0.3	0.4	0.8	0.9	0.1	-0.9	0.0
Severe depression (siblings)	0.3	0.4	0.6	-0.7	-0.8	0.0	-0.6
Pack years adult smoking proportion	0.8	1.2	2.0	-1.3	-1.0	-0.1	-1.4
Impedance of leg (right)	0.7	3.3	10.8	0.6	-0.6	3.3	-1.3
Leg fat-free mass (left)	1.5	7.9	26.0	0.3	-1.0	-5.1	2.1
Trunk fat percentage	0.7	3.0	8.4	1.4	-1.3	-2.9	-0.1
Hand grip strength (right)	0.4	1.1	3.7	-0.2	-0.1	1.9	-0.7
Townsend deprivation index at recruitment	2.1	2.9	3.9	-1.8	-2.0	1.1	-1.8
Current tobacco smoking	0.1	0.2	0.8	-0.1	0.2	0.3	-0.9
Average weekly fortified wine intake	0.6	0.7	2.0	0.1	1.4	0.8	0.5
Maternal smoking around birth	0.3	0.5	1.5	-1.2	-0.5	-0.4	-0.4
Fed-up feelings	0.8	1.4	3.9	-0.6	1.2	0.4	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.6	-1.1	-0.2	1.2	-0.0
Relative age voice broke	0.1	0.2	0.7	0.8	-0.1	0.0	0.2
Taking other prescription medications	0.9	1.4	4.5	0.8	-2.1	-0.6	0.5
Age when periods started (menarche)	0.4	0.9	2.4	1.1	1.6	0.3	0.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.9	-0.4	0.9	-1.0	0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	7.6	-1.1	-1.7	2.8	-1.0
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.1	1.0	0.4	-0.8	1.4
Qualifications: CSEs or equivalent	1.8	2.4	4.4	-0.1	-2.1	-2.1	1.0
Serious illness, injury or assault to yourself	1.4	1.6	3.3	-0.9	-1.8	1.6	-0.0
High blood pressure	0.4	1.0	2.0	0.4	-0.0	1.4	1.3
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.7	0.7	-0.3	0.8	0.8
Multivitamins +/- minerals	1.2	1.5	2.7	1.5	-1.0	-0.4	1.6
Stomach or abdominal pain in last month	2.1	2.6	4.0	1.7	1.5	-1.1	2.0
Supplements: Glucosamine	0.7	0.9	3.4	1.8	0.2	0.1	0.5
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	2.6	-0.4	-0.3	-1.6	-0.5
Medication: Atenolol	0.2	0.2	0.6	0.1	0.5	0.8	0.0
Medication: Levothyroxine sodium	0.6	1.0	2.6	0.6	-0.8	-1.6	0.4
Sitting height	0.6	4.3	12.7	0.8	-0.9	-3.6	1.8
Chronic bronchitis/emphysema (father)	0.9	1.1	3.5	-0.5	-1.9	-0.8	0.3
High blood pressure (mother)	0.1	0.2	0.4	0.6	-0.1	0.1	0.5
Body mass index (BMI)	0.4	1.8	6.9	0.3	-0.4	-2.6	0.2
Impedance of leg (left)	1.1	5.4	16.1	0.2	-0.5	4.0	-2.3
Leg predicted mass (left)	1.5	7.8	25.3	0.1	-1.0	-5.0	2.2
Trunk fat mass	1.1	4.8	14.8	1.4	-1.5	-3.9	0.6
Waist circumference	0.5	1.8	5.2	0.7	-1.2	-2.3	-0.0
Number of incorrect matches in round	0.3	0.5	0.8	0.3	0.9	-0.8	-0.6
Past tobacco smoking	1.0	1.9	5.5	0.3	-0.6	-2.3	1.2
Alcohol usually taken with meals	0.9	1.4	3.0	1.5	1.7	-0.5	0.4
Nervous feelings	1.2	2.3	4.0	-2.0	1.2	1.9	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.3	-0.7	1.2	0.8	-0.2
Hearing difficulty/problems with background noise	0.3	0.4	0.8	0.8	0.9	-0.3	-0.4
Hair/balding pattern: Pattern 2	1.0	1.2	2.4	0.8	1.4	1.6	-0.2
Had menopause	1.4	1.7	2.6	1.5	1.0	-1.1	1.6
Had other major operations	0.5	0.6	1.4	-0.4	0.2	1.2	0.9
Forced vital capacity (FVC)	0.2	0.7	1.5	0.4	-0.5	-1.2	0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	4.1	-0.7	-1.8	2.0	-1.1
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	4.3	0.2	-0.1	0.4	-2.1
Qualifications: None of the above	0.9	1.8	3.2	-1.1	-1.8	-0.6	-1.6
Financial difficulties in last 2 years	0.4	0.6	2.0	-0.0	1.4	-0.0	0.5
Mouth/teeth dental problems	0.8	1.3	3.5	0.1	-1.1	1.9	-0.6
Heart attack	2.3	3.0	9.5	0.2	-0.5	3.1	-1.5
Allergy	0.5	1.3	4.3	-2.1	-0.5	0.1	-0.7
Pain all over the body in last month	0.1	0.1	0.3	-0.0	0.4	0.5	-0.1
Diabetes (self-reported)	1.3	2.0	4.0	0.7	-1.7	-2.0	0.6
Hayfever/allergic rhinitis (self-reported)	3.3	4.3	6.9	-2.2	-0.1	2.6	-2.3
Medication: Ramipril	2.0	2.6	6.8	0.4	-1.6	2.6	-0.8
Medication: Simvastatin	0.4	0.6	1.3	0.7	-0.8	-0.2	-1.1
Fluid intelligence score	0.6	1.3	1.9	0.2	-1.1	1.4	1.4
Illnesses of siblings	0.8	1.2	3.3	-1.8	0.8	0.4	-0.8
Neuroticism score	0.8	1.8	2.3	-1.5	1.2	1.3	1.3
Weight	1.2	5.7	19.7	0.6	-1.2	-4.4	1.1
Impedance of arm (right)	0.2	0.9	2.3	1.5	-0.9	-0.7	0.4
Arm fat percentage (right)	1.0	4.0	12.1	1.7	-0.6	-3.5	0.6
Trunk fat-free mass	0.9	5.3	17.5	0.1	-0.5	-4.2	1.9
Hip circumference	2.2	9.3	29.5	1.4	-1.8	-5.4	1.7
Time employed in main current job	0.1	0.1	0.4	0.2	-0.6	0.1	-0.1
Alcohol intake versus 10 years previously	0.6	0.9	1.7	-0.5	-0.9	0.9	-1.3
Father’s age at death	0.5	0.7	2.3	1.5	0.4	-0.3	0.5
Worrier / anxious feelings	1.1	2.0	5.1	-2.3	0.5	0.5	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.8	-0.9	0.5	-0.6	0.1
Falls in the last year	0.4	0.6	1.1	0.1	0.9	1.1	-0.5
Hair/balding pattern: Pattern 3	0.4	0.6	1.7	-0.7	-0.6	1.3	0.1
Number of live births	0.8	1.1	3.3	1.8	0.8	0.7	0.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.8	0.2	-0.6	-1.0	1.3
Pulse rate	0.3	0.5	1.1	-0.2	-1.0	1.0	-0.3
Happiness	0.6	0.7	1.3	-0.9	-0.2	-1.1	0.9
Noisy workplace	1.4	1.7	2.5	-1.6	1.3	0.6	-1.5
Qualifications: A levels/AS levels or equivalent	1.6	3.6	8.7	2.0	0.6	-1.2	3.0
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	1.9	1.3	1.4	0.3	0.9
Mouth/teeth dental problems: Dentures	2.6	4.4	9.0	-0.5	-2.6	-3.0	-1.1
Asthma	0.7	1.4	2.5	1.6	0.9	-1.4	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.4	1.5	-0.8	-0.5	-0.6
Medication: Cholesterol lowering	0.5	0.8	1.9	1.0	-1.4	-0.6	-0.1
Depression (self-reported)	1.5	1.8	2.7	-1.6	-0.2	1.5	-1.5
Medication: Lansoprazole	0.3	0.3	0.9	1.0	0.3	0.1	0.3
Prospective memory result	0.1	0.2	0.6	0.7	0.1	0.0	0.3
Lung cancer (father)	0.5	0.6	1.3	-0.8	-0.7	0.2	-1.1
Illnesses of mother	1.0	1.3	2.3	-1.5	0.9	-1.1	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.0	0.4	-0.3	-0.6	1.0
Pulse wave Arterial Stiffness index	0.3	0.4	0.6	0.4	-0.6	-0.7	0.8
Impedance of arm (left)	0.2	0.9	2.2	1.5	-1.1	-0.5	-0.0
Arm fat mass (right)	1.0	4.2	14.1	1.1	-0.8	-3.8	0.9
Trunk predicted mass	1.0	5.4	17.7	0.1	-0.5	-4.2	1.9
Standing height	0.7	6.7	18.6	0.5	-2.0	-4.3	1.9
Length of working week for main job	0.2	0.2	0.5	0.7	-0.1	-0.3	0.0
Exposure to tobacco smoke at home	0.2	0.2	0.5	0.0	-0.7	0.1	0.5
Breastfed as a baby	3.2	4.0	7.0	2.4	-0.3	-1.8	2.6
Tense / ‘highly strung’	0.6	1.0	3.1	-1.8	0.2	0.5	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.2	-1.0	1.1	1.5	1.3
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	0.5	-0.3	0.6	0.4
Birth weight of first child	0.9	1.7	3.9	-2.0	-0.1	-0.4	-1.7
Peak expiratory flow (PEF)	0.3	0.8	2.4	0.0	0.2	1.5	0.8
Pulse wave reflection index	1.4	1.7	2.2	1.5	1.1	-1.1	1.4
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.3	0.4	-0.1	-0.6
Loud music exposure frequency	0.8	0.9	1.8	-0.4	1.3	-1.2	-0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	-0.6	0.7	0.2	0.5
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	5.3	0.5	2.3	0.3	0.6
Blood clot in the leg (DVT)	0.4	0.5	1.3	0.5	-1.1	0.4	0.6
Medication: Paracetamol	0.5	0.8	2.6	0.1	-0.8	-0.3	-1.6
Headache pain in last month	1.0	1.7	3.3	1.4	1.8	-1.1	0.7
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	1.9	-1.1	1.0	-1.4	-0.6
Glaucoma (self-reported)	1.1	1.3	4.1	0.6	-0.1	-2.0	0.9
Gout (self-reported)	4.2	5.8	12.4	-3.5	-2.3	-0.2	-2.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.2	0.9	-0.5	-1.1	-0.2
Medication: Amlodipine	0.6	0.9	1.2	1.0	0.7	1.1	0.9
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.0	0.0	1.0	0.8	-0.6
Birth weight	0.8	1.7	6.5	-0.1	-2.5	0.2	-0.6
Chronic bronchitis/emphysema (mother)	0.7	0.9	1.6	1.3	1.2	-0.1	0.6
High blood pressure (siblings)	0.7	1.0	2.3	0.8	-0.1	1.5	1.0
Forced vital capacity (FVC), Best measure	0.2	0.7	1.6	0.7	0.1	-1.3	0.8
Body fat percentage	0.6	2.5	6.8	1.3	-1.2	-2.6	-0.1
Leg fat percentage (right)	0.5	1.7	3.5	1.9	-0.7	-1.7	0.3
Arm fat-free mass (right)	0.6	3.1	10.0	-0.6	-1.0	-3.2	1.1
Exposure to tobacco smoke outside home	0.5	0.6	1.9	-0.2	-0.6	0.6	-1.4
Comparative body size at age 10	0.1	0.2	0.5	0.7	-0.6	-0.0	0.4
Number of full brothers	0.5	0.6	1.3	0.7	-0.4	-0.6	-1.2
Worry too long after embarrassment	1.1	1.9	3.0	-1.2	1.4	1.1	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.4	-0.7	-0.0	0.8	1.6
Wheeze or whistling in the chest in last year	0.8	1.4	4.6	2.2	0.5	-0.7	-0.4
Number of children fathered	0.5	0.6	2.0	0.4	0.1	-1.4	0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	3.8	0.3	-0.6	0.5	-1.9
Age at first live birth	0.8	1.5	3.1	1.5	0.6	1.8	0.3
Pulse wave peak to peak time	0.1	0.1	0.2	-0.5	0.3	0.0	-0.4
Health satisfaction	0.2	0.3	0.9	0.1	1.0	0.1	0.3
Shortness of breath walking on level ground	1.1	1.3	3.2	1.8	1.3	0.1	-0.5
Qualifications: College or University degree	0.4	1.3	2.2	0.9	1.5	1.0	1.1
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.6	0.1	-0.2	0.1
Mouth/teeth dental problems: Loose teeth	0.9	1.0	3.1	-0.7	-1.8	0.7	-0.1
Emphysema/chronic bronchitis	1.8	2.1	6.1	2.5	1.2	0.0	-0.8
Medication for pain relief, constipation, heartburn	1.0	1.7	3.8	-0.4	1.9	-1.1	1.3
Neck or shoulder pain in last month	1.3	1.9	5.5	-0.4	-2.4	-1.3	0.2
Medication: Blood pressure	0.8	1.4	3.3	1.0	-0.8	1.8	0.7
Angina (self-reported)	1.3	1.7	3.2	-0.7	-1.8	1.5	-1.0
Migraine (self-reported)	2.5	3.1	7.8	0.6	0.2	-2.0	2.8
Medication: Ibuprofen	0.7	0.8	1.5	1.1	-0.7	-0.3	-1.2
Medication: Allopurinol	3.2	4.3	8.6	-2.9	-2.1	-0.4	-2.0
Medication: Omeprazole	0.4	0.5	1.2	0.2	-0.8	-0.3	-1.1
Medication: Seretide 50 evohaler	1.2	1.4	4.3	-0.4	-2.1	0.3	-1.0
Mean time to correctly identify matches	0.1	0.2	0.4	0.6	-0.0	-0.3	0.5
Heart disease (mother)	1.1	1.3	2.6	0.4	0.0	1.6	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	3.2	1.8	0.2	0.3	0.6
Whole body fat mass	1.0	4.1	12.8	1.1	-1.5	-3.6	0.6
Leg fat mass (right)	0.8	3.3	9.7	1.4	-1.0	-3.1	0.6
Arm predicted mass (right)	0.7	3.4	11.2	-0.4	-1.0	-3.3	1.1
Pulse rate, automated reading	0.2	0.7	1.0	-1.0	-0.9	-0.0	1.0
Alcohol intake frequency.	0.9	2.2	4.8	0.5	0.7	-1.8	2.2
Comparative height size at age 10	0.6	3.3	9.8	0.3	-1.8	-3.1	0.3
Number of full sisters	2.2	2.7	5.9	-0.6	-0.8	2.0	-2.4
Suffer from ‘nerves’	1.6	2.5	5.8	-2.4	0.3	1.9	-0.6
Overall health rating	0.0	0.1	0.2	0.4	0.4	0.0	0.3
Chest pain or discomfort	1.5	2.2	4.4	1.4	-0.6	-1.4	2.1
Had major operations	0.6	0.7	2.0	-0.1	-0.8	-1.4	-0.4
Age at last live birth	0.4	0.6	2.4	0.1	-0.3	1.5	-0.3
Family relationship satisfaction	0.8	1.0	3.3	-1.8	-0.5	0.3	-0.6
Leg pain on walking	1.3	1.7	6.1	0.7	2.5	0.0	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.3	1.1	-0.6	-1.2	1.5
Commuting to job workplace: Car/motor vehicle	1.8	2.1	5.6	1.4	2.4	0.2	-0.8
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	1.7	0.5	-1.3	-1.3	1.2
Medication: Aspirin	1.3	1.8	3.6	0.3	-1.8	1.9	-0.0
Supplements: Vitamin C	1.0	1.2	3.0	-0.3	-1.7	0.5	-1.3
Knee pain experienced in last month	0.3	0.5	1.2	0.6	-1.1	0.1	-0.5
Hypertension (Self-reported)	0.5	1.4	2.6	0.1	-0.4	1.6	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	3.8	0.9	1.9	0.2	1.7
Illnesses of father: Heart disease	0.5	0.7	2.1	0.0	-1.4	0.5	0.7
Illnesses of siblings: Diabetes	3.1	3.8	8.0	1.6	-0.8	-2.8	1.9
Smoking status: Previous	0.7	1.1	3.8	-0.1	0.3	2.0	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.4	0.9	1.1	-1.2	0.6
Whole body fat-free mass	1.0	5.8	19.3	-0.0	-0.8	-4.4	1.8
Leg fat-free mass (right)	1.2	6.7	22.6	-0.0	-0.9	-4.8	1.8
Arm fat percentage (left)	0.9	3.8	11.7	1.6	-0.8	-3.4	0.4
Average weekly red wine intake	0.1	0.2	0.4	-0.3	0.3	0.6	-0.2
Handedness (chirality/laterality): Left-handed	1.3	1.5	3.0	-0.0	1.4	1.7	-1.1
Mood swings	0.8	1.4	5.1	0.3	0.5	-0.4	2.2
Loneliness, isolation	0.6	0.8	1.7	-1.0	-0.2	1.3	-0.7
Long-standing illness, disability or infirmity	0.4	0.6	1.5	1.2	-0.3	-0.1	0.9
Ever had bowel cancer screening	1.9	2.2	6.7	-0.2	-2.6	0.2	-1.4
Diabetes diagnosed by doctor	0.6	0.9	3.4	0.4	-0.4	-1.8	0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.5	1.9	0.2	1.0	1.0
Friendships satisfaction	0.7	0.8	2.8	-1.7	0.5	-0.4	0.3
Qualifications: nursing, teaching	1.2	1.8	4.6	0.7	-0.7	-1.3	2.1
Commuting to job workplace: Walk	0.7	0.8	2.6	-0.5	-0.4	-1.6	0.1
Eye problems/disorders: Cataract	0.4	0.5	1.6	-0.1	0.5	1.3	0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.7	-0.6	0.7	0.8	0.4
Medication for cholesterol	0.7	1.1	3.2	-0.6	-0.9	-0.2	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.4	-1.6	-1.1	0.2	-1.0
Back pain experienced in last month	0.9	1.4	2.7	0.8	1.6	-1.4	0.3
Mineral and other dietary supplements	0.6	0.8	2.4	0.6	1.6	0.2	-0.8
Breast cancer (self-reported)	0.5	0.7	2.4	0.1	-1.5	-0.5	0.0
Asthma (self-reported)	0.7	1.3	2.7	1.6	0.6	-1.4	0.5
Osteoporosis (self-reported)	0.8	1.1	2.5	1.6	1.1	0.6	0.5
Osteoarthritis (self-reported)	0.5	0.6	1.2	-0.2	-1.1	0.8	-0.8
Medication: Aspirin	1.6	2.1	4.8	0.3	-2.2	1.8	-0.2
Medication: Gliclazide	0.5	0.6	0.8	-0.7	-0.9	-0.9	0.3
Illnesses of father: None of the above (group 1)	0.7	0.9	3.6	-0.2	0.0	0.3	-1.9
Smoking status: Current	0.1	0.2	0.8	0.0	0.0	0.0	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.1	1.8	0.2	-0.7	1.1
Whole body water mass	1.0	5.9	19.8	0.1	-0.7	-4.4	1.9
Leg predicted mass (right)	1.2	6.6	22.6	-0.1	-0.9	-4.8	1.7
Arm fat mass (left)	1.1	4.4	14.9	1.0	-1.0	-3.9	0.8
Number of self-reported non-cancer illnesses	0.3	0.4	1.5	0.4	-0.3	0.2	1.2
Average weekly champagne plus white wine intake	0.2	0.3	0.9	1.0	-0.4	0.4	-0.2
Miserableness	0.2	0.3	1.2	-0.3	-0.1	1.1	0.2
Guilty feelings	2.7	4.1	8.4	-0.4	2.9	2.7	-0.7
Wears glasses or contact lenses	1.1	1.3	3.1	1.1	0.3	-0.9	1.8
Ever taken oral contraceptive pill	1.6	1.8	6.4	-0.4	0.4	0.9	-2.5
Hearing aid user	0.7	0.8	2.6	-0.3	0.7	-1.6	-0.3
Mother’s age at death	1.2	1.5	5.6	0.3	0.0	-2.4	0.6
Financial situation satisfaction	0.6	0.8	1.8	-1.3	-0.0	-0.0	-1.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.8	0.0	1.7	-0.6	0.1
Commuting to job workplace: Public transport	0.8	1.0	1.6	0.6	-1.0	-1.3	0.9
Eye problems/disorders: Glaucoma	0.9	1.1	1.9	1.4	0.5	-1.2	0.9
Medication: Blood pressure	0.3	0.6	1.2	0.8	0.1	0.9	1.1
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.4	1.6	0.9	0.5	0.7
Supplements: Fish oil (including cod liver oil)	2.1	2.8	7.0	-1.7	-2.6	-1.0	0.3
High cholesterol (Self-reported)	0.5	0.8	1.2	0.1	-1.1	1.0	-1.1
Medication: Bendroflumethiazide	0.9	1.4	4.1	0.8	-0.8	0.7	2.0
Medication: Paracetamol	0.6	0.9	3.1	-0.2	-0.7	-0.3	-1.8
Medication: Lisinopril	0.6	0.8	1.7	-0.5	1.3	1.0	-0.5
Medication: Atorvastatin	0.4	0.5	1.6	-0.3	-1.3	0.4	0.2
Illnesses of father: High blood pressure	1.7	2.1	3.6	1.5	0.9	1.2	1.9
Alcohol drinker status: Never	0.7	0.8	2.5	-0.3	-1.6	0.4	0.7
Ever smoked	2.0	3.5	7.9	0.2	2.1	2.8	-1.3
Basal metabolic rate	1.1	6.0	20.4	0.2	-0.8	-4.5	1.7
Leg fat percentage (left)	0.4	1.3	2.9	1.7	-0.4	-1.4	-0.1
Arm fat-free mass (left)	0.6	2.8	9.7	-0.7	-0.8	-3.1	0.8
Number of operations (self-reported)	0.1	0.2	0.3	0.0	-0.6	-0.4	-0.4
Average weekly beer plus cider intake	1.0	1.5	2.9	0.0	-1.6	0.8	-1.7
Irritability	0.7	1.2	2.2	-1.3	-0.7	0.7	1.5
Risk taking	1.7	2.4	3.5	-1.0	-1.6	1.6	-1.9
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	-0.7	0.2	-0.1	-0.6
Fractured/broken bones in last 5 years	0.5	0.7	1.4	-1.2	-0.1	1.1	-0.2
Age started oral contraceptive pill	0.1	0.1	0.3	0.6	-0.4	-0.0	0.2
Diastolic blood pressure, automated reading	0.5	1.5	2.2	0.7	-1.0	1.5	1.5
Ever depressed for a whole week	0.4	0.4	1.0	-0.1	-0.1	1.0	-0.9
Unable to work because of sickness or disability	0.5	0.7	2.6	0.3	1.6	-0.1	0.3
Commuting to job workplace: Cycle	0.4	0.4	0.9	1.0	-0.8	-0.0	0.3
Myopia	1.6	2.3	4.6	-0.0	-2.1	-1.3	1.6
Vascular/heart problems diagnosed by doctor	0.6	1.5	5.1	-0.4	0.5	-2.3	-0.7
Cholesterol lowering medication	1.0	1.4	2.5	-1.6	-0.5	1.2	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.6	0.8	0.5	-0.2	-0.8
Pain experienced in last month	0.1	0.2	0.2	-0.5	0.3	-0.4	0.4
Supplements: Calcium	1.5	1.7	4.9	0.7	1.0	0.7	2.2
Basal cell carcinoma (self-reported)	0.7	0.9	2.5	0.1	0.1	1.6	1.0
Heart attack/myocardial infarction (self-reported)	2.7	3.5	10.7	0.1	-0.7	3.3	-1.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	0.6	-1.0	0.5	0.5
Heart disease (siblings)	0.3	0.3	0.5	0.4	-0.7	-0.3	-0.7
Alcohol drinker status: Previous	0.9	1.0	2.2	0.5	1.0	-0.8	1.5
Pack years of smoking	1.0	1.4	3.0	-1.0	-1.3	0.0	-1.7
Impedance of whole body	0.3	1.3	2.5	0.8	-0.8	1.6	-1.2
Leg fat mass (left)	0.7	2.9	8.5	1.4	-0.8	-2.9	0.4
Arm predicted mass (left)	0.7	3.5	12.5	-0.3	-0.6	-3.5	1.0