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chr6:75,101,682-77,324,522

Best TWAS P=2.72e-24 · Best GWAS P=2.13e-32 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
16	ROSMAP	Brain Pre-frontal Cortex	SENP6	0.17	0.14	blup	355	0.17	2.5e-21	-6.8	-10.2	2.7e-24	-0.41	1.00	0.00	TRUE
4	GTEx	Artery Tibial	SENP6	0.08	0.00	enet	5	0.00	8.2e-01	10.8	9.9	4.2e-23	0.76	0.04	0.46	TRUE
14	METSIM	Adipose	COL12A1	0.04	0.01	blup	309	0.02	5.1e-04	-1.4	-8.2	2.2e-16	-0.48	0.12	0.53	TRUE
12	GTEx	Thyroid	MYO6	0.12	0.11	enet	15	0.12	1.5e-09	7.9	8.0	1.2e-15	0.37	1.00	0.00	TRUE
19	The Cancer Genome Atlas	Prostate Adenocarcinoma	MYO6	0.04	0.03	blup	105	0.05	7.0e-06	-7.1	-7.8	5.0e-15	-0.23	0.67	0.02	TRUE
17	ROSMAP	Brain Pre-frontal Cortex	MYO6	0.09	0.07	enet	27	0.08	4.1e-10	7.5	-7.6	3.8e-14	-0.40	1.00	0.00	TRUE
7	GTEx	Lung	MYO6	0.09	0.08	enet	21	0.08	1.6e-06	7.5	6.2	4.5e-10	0.24	0.94	0.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	FILIP1	0.03	0.01	bslmm	344	0.02	3.2e-03	-3.0	-6.2	6.3e-10	-0.10	0.14	0.03	TRUE
3	GTEx	Artery Aorta	MYO6	0.15	0.05	lasso	6	0.09	1.6e-05	-3.6	5.2	1.5e-07	0.46	0.41	0.02	TRUE
8	GTEx	Muscle Skeletal	FILIP1	0.04	0.00	enet	13	0.01	1.6e-02	11.1	-7.7	9.6e-15	-0.59	0.15	0.10	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MYO6	0.21	0.07	bslmm	366	0.12	8.8e-15	7.9	-7.2	5.9e-13	-0.37	1.00	0.00	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	MYO6	0.11	0.03	lasso	3	0.04	2.1e-03	10.8	-7.1	1.5e-12	-0.70	0.15	0.46	FALSE
11	GTEx	Spleen	SENP6	0.21	0.11	lasso	5	0.06	1.3e-02	-6.9	-6.9	5.5e-12	-0.26	0.12	0.09	FALSE
6	GTEx	Heart Left Ventricle	MYO6	0.09	0.00	lasso	7	0.00	5.6e-01	-7.5	6.7	1.6e-11	0.13	0.16	0.04	FALSE
5	GTEx	Artery Tibial	MYO6	0.07	0.01	enet	16	0.01	2.3e-02	7.9	6.1	1.1e-09	0.28	0.17	0.12	FALSE
13	GTEx	Whole Blood	TMEM30A	0.05	0.00	enet	17	0.01	2.8e-02	-3.0	5.9	3.6e-09	0.20	0.08	0.03	FALSE
18	The Cancer Genome Atlas	Lung Adenocarcinoma	IMPG1	0.05	0.03	lasso	2	0.02	2.4e-03	5.8	5.6	1.7e-08	0.59	0.16	0.04	FALSE
15	NTR	Blood	SENP6	0.02	0.01	lasso	2	0.01	6.5e-05	5.4	-5.6	1.8e-08	0.11	0.94	0.00	FALSE
9	GTEx	Nerve Tibial	MYO6	0.12	0.02	enet	12	0.06	3.4e-05	7.5	5.4	5.7e-08	0.23	0.88	0.00	FALSE