Best TWAS P=2.72e-24 · Best GWAS P=2.13e-32 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FILIP1 | 0.03 | 0.01 | bslmm | 344 | 0.02 | 3.2e-03 | -3.0 | -6.2 | 6.3e-10 | -0.10 | 0.14 | 0.03 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | MYO6 | 0.21 | 0.07 | bslmm | 366 | 0.12 | 8.8e-15 | 7.9 | -7.2 | 5.9e-13 | -0.37 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Artery Aorta | MYO6 | 0.15 | 0.05 | lasso | 6 | 0.09 | 1.6e-05 | -3.6 | 5.2 | 1.5e-07 | 0.46 | 0.41 | 0.02 | TRUE |
| 4 | GTEx | Artery Tibial | SENP6 | 0.08 | 0.00 | enet | 5 | 0.00 | 8.2e-01 | 10.8 | 9.9 | 4.2e-23 | 0.76 | 0.04 | 0.46 | TRUE |
| 5 | GTEx | Artery Tibial | MYO6 | 0.07 | 0.01 | enet | 16 | 0.01 | 2.3e-02 | 7.9 | 6.1 | 1.1e-09 | 0.28 | 0.17 | 0.12 | FALSE |
| 6 | GTEx | Heart Left Ventricle | MYO6 | 0.09 | 0.00 | lasso | 7 | 0.00 | 5.6e-01 | -7.5 | 6.7 | 1.6e-11 | 0.13 | 0.16 | 0.04 | FALSE |
| 7 | GTEx | Lung | MYO6 | 0.09 | 0.08 | enet | 21 | 0.08 | 1.6e-06 | 7.5 | 6.2 | 4.5e-10 | 0.24 | 0.94 | 0.00 | TRUE |
| 8 | GTEx | Muscle Skeletal | FILIP1 | 0.04 | 0.00 | enet | 13 | 0.01 | 1.6e-02 | 11.1 | -7.7 | 9.6e-15 | -0.59 | 0.15 | 0.10 | FALSE |
| 9 | GTEx | Nerve Tibial | MYO6 | 0.12 | 0.02 | enet | 12 | 0.06 | 3.4e-05 | 7.5 | 5.4 | 5.7e-08 | 0.23 | 0.88 | 0.00 | FALSE |
| 10 | GTEx | Skin Not Sun Exposed Suprapubic | MYO6 | 0.11 | 0.03 | lasso | 3 | 0.04 | 2.1e-03 | 10.8 | -7.1 | 1.5e-12 | -0.70 | 0.15 | 0.46 | FALSE |
| 11 | GTEx | Spleen | SENP6 | 0.21 | 0.11 | lasso | 5 | 0.06 | 1.3e-02 | -6.9 | -6.9 | 5.5e-12 | -0.26 | 0.12 | 0.09 | FALSE |
| 12 | GTEx | Thyroid | MYO6 | 0.12 | 0.11 | enet | 15 | 0.12 | 1.5e-09 | 7.9 | 8.0 | 1.2e-15 | 0.37 | 1.00 | 0.00 | TRUE |
| 13 | GTEx | Whole Blood | TMEM30A | 0.05 | 0.00 | enet | 17 | 0.01 | 2.8e-02 | -3.0 | 5.9 | 3.6e-09 | 0.20 | 0.08 | 0.03 | FALSE |
| 14 | METSIM | Adipose | COL12A1 | 0.04 | 0.01 | blup | 309 | 0.02 | 5.1e-04 | -1.4 | -8.2 | 2.2e-16 | -0.48 | 0.12 | 0.53 | TRUE |
| 15 | NTR | Blood | SENP6 | 0.02 | 0.01 | lasso | 2 | 0.01 | 6.5e-05 | 5.4 | -5.6 | 1.8e-08 | 0.11 | 0.94 | 0.00 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | SENP6 | 0.17 | 0.14 | blup | 355 | 0.17 | 2.5e-21 | -6.8 | -10.2 | 2.7e-24 | -0.41 | 1.00 | 0.00 | TRUE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | MYO6 | 0.09 | 0.07 | enet | 27 | 0.08 | 4.1e-10 | 7.5 | -7.6 | 3.8e-14 | -0.40 | 1.00 | 0.00 | TRUE |
| 18 | The Cancer Genome Atlas | Lung Adenocarcinoma | IMPG1 | 0.05 | 0.03 | lasso | 2 | 0.02 | 2.4e-03 | 5.8 | 5.6 | 1.7e-08 | 0.59 | 0.16 | 0.04 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MYO6 | 0.04 | 0.03 | blup | 105 | 0.05 | 7.0e-06 | -7.1 | -7.8 | 5.0e-15 | -0.23 | 0.67 | 0.02 | TRUE |