Hub : Genes

FAM46A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.3090	0.0990	0.00110	0.187	NA	0.151	NA	0.164	3.5e-06	NA	3.1e-05	NA	1.5e-05
2	GTEx	Esophagus Gastroesophageal Junction	0.2180	0.0710	0.00300	0.003	NA	-0.003	NA	0.000	2.5e-01	NA	4.4e-01	NA	3.2e-01
3	ROSMAP	Brain Pre-frontal Cortex	0.0764	0.0266	0.00024	0.011	0.025	0.022	0.021	0.005	1.1e-02	2.7e-04	6.3e-04	7.5e-04	6.8e-02
4	YFS	Blood	0.0330	0.0116	0.00027	0.000	0.013	0.006	0.012	0.003	3.8e-01	3.7e-05	3.4e-03	4.7e-05	3.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.3	0.5	1.7	0.6	1.3	-0.0	0.1
Bipolar Disorder or Schizophrenia	0.5	1.1	2.5	0.1	1.4	-0.5	1.6
Depressed Affect (Nagel 2018)	1.9	4.1	6.5	-2.0	0.9	-2.5	-2.3
Depression (Nagel 2018)	0.8	1.3	2.4	-1.3	1.5	-1.0	0.3
Intelligence (Savage-Jansen 2018)	1.5	4.6	9.5	-2.5	1.6	3.1	-0.6
Neuroticism (Nagel 2018)	0.2	0.6	1.0	-0.9	1.0	-0.7	-0.1
Schizophrenia (2018)	0.6	1.2	3.8	-0.3	0.7	-0.6	1.9
Schizophrenia vs Biploar Disorder	1.1	1.4	2.9	-1.3	1.0	0.3	-1.7
Worry (Nagel 2018)	0.1	0.3	0.6	-0.4	0.8	0.5	0.2
Alzheimer’s Disease (in mother)	0.1	0.2	0.3	-0.4	-0.0	-0.5	0.4
Alzheimer’s Disease (in father)	1.0	1.1	2.0	0.9	-1.4	-1.3	0.3
Alzheimer’s Disease (including proxy)	0.7	1.0	3.3	-0.8	-0.2	-1.8	0.5
Crohns Disease (2017)	0.3	0.7	1.5	-0.3	-1.1	-1.2	-0.1
Irritable Bowel Disease (IBD)	1.0	2.3	5.4	-0.4	-2.3	-1.7	-0.9
Ulcerative Colitis (UC)	1.5	2.9	8.3	-0.3	-2.9	-1.0	-1.5
Major Depression (MDD)	0.9	1.1	4.1	0.3	2.0	0.2	0.0
Reaction Time	2.5	4.8	10.6	0.7	2.8	-0.9	3.2
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.4	-1.5	0.4	0.8	-0.9
Breast Cancer	0.1	0.3	1.3	-0.0	0.3	-0.0	-1.1
Ovarian Cancer	1.2	1.5	2.6	1.1	1.2	1.0	-1.6
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	2.4	3.5	4.1	2.0	-1.5	2.0	2.0
Bipolar Disorder (2011)	0.3	0.3	0.9	-0.2	-0.3	1.0	0.2
Body Mass Index (BMI) (2010)	0.4	0.6	1.3	-0.3	1.1	-0.6	0.9
Coronary Artery Disease (CAD)	2.6	3.1	6.8	1.0	-2.6	-2.2	-0.2
Crohns Disease (2012)	0.6	0.9	1.5	-1.1	-0.1	-1.2	-1.0
Mean Putamen Volume	1.6	1.8	6.7	-0.4	0.2	2.6	0.6
Fasting Glucose	0.5	0.6	1.2	0.8	-0.6	1.1	0.4
HbA1C	1.8	2.0	4.7	-0.5	1.7	2.2	-0.2
HDL Cholesterol	0.5	0.8	1.2	-0.0	-1.0	-1.1	1.1
LDL Cholesterol	0.4	0.6	1.4	0.4	-0.3	1.2	0.9
Lupus	0.6	0.8	2.6	0.1	-0.3	-0.8	-1.6
Neuroticism (2016)	0.7	0.9	2.8	-0.2	1.7	0.1	-0.9
Primary Biliary Cirrhosis	0.5	0.8	1.2	0.7	-0.8	-1.1	0.9
Rheumatoid Arthritis	0.6	0.9	1.3	1.0	0.7	-1.1	-0.8
Schizophrenia (2014)	0.9	1.9	4.0	-1.6	2.0	0.1	1.1
Triglycerides	1.0	1.6	6.2	-0.5	-0.0	-0.2	-2.5
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.8	-0.1	-0.0	0.9	-0.3
Ulcerative Colitis	1.2	1.8	4.1	-0.3	-2.0	-0.4	-1.6
Blood Eosinophil Count	0.3	2.0	4.6	-1.4	-0.5	-2.1	-1.1
Blood Platelet Count	0.1	1.5	1.9	-0.9	-1.1	-1.4	1.4
Blood Red Count	0.3	2.9	7.0	2.6	0.2	0.1	2.1
Blood White Count	0.6	4.2	13.6	-3.7	1.8	0.0	0.0
Heel T-Score	1.2	9.5	22.0	4.7	-2.8	-0.4	2.8
BMI	0.3	1.6	5.0	1.0	-0.7	0.1	2.2
Height	1.7	32.0	90.6	-4.1	4.1	9.5	-1.9
Waist Hip Ratio (WHR)	1.1	4.8	8.6	2.9	-1.5	2.9	0.2
Systolic Blood Pressure	1.0	5.1	13.0	2.2	-3.6	-1.4	0.8
Smoking Status	0.2	0.4	0.6	-0.6	0.7	0.3	0.8
Allergy or Eczema	0.6	1.5	5.3	-2.3	0.3	-0.7	0.0
Cardiovascular Disease	1.4	4.7	11.3	1.9	-3.4	-1.5	1.2
Hypothyroidism (self reported)	1.0	2.2	3.9	-0.7	1.5	2.0	-1.5
Respiratory disease	0.6	1.3	2.8	-1.0	-1.7	-1.2	-0.3
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.2	-1.1	0.0	0.0	-1.5
Lung FEV1/FVC ratio	0.1	0.5	0.9	-0.1	-0.9	0.3	-0.9
Lung FVC	0.1	0.7	1.6	1.0	-0.3	0.4	1.3
Neuroticism	0.5	1.1	2.5	-0.9	1.1	-0.3	-1.6
Chronotype (morning person)	0.4	0.9	2.5	-0.7	-0.6	1.6	0.4
Hair Pigment	0.2	5.4	10.5	-0.5	2.7	3.2	1.8
Tanning	0.6	7.8	26.2	1.3	-1.7	-5.1	-0.8
Hand grip strength (left)	0.6	1.5	5.6	0.3	-0.3	2.4	0.6
Number of treatments/medications taken	1.3	2.3	4.1	-1.7	-0.9	-2.0	1.1
Average weekly spirits intake	0.7	0.8	1.7	-0.7	0.2	-1.3	-1.0
Sensitivity / hurt feelings	0.1	0.2	0.4	0.1	0.6	0.5	0.3
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.6	-0.7	0.9	-1.3	-0.1
Hearing difficulty/problems: Yes	0.7	1.1	2.3	1.5	0.7	0.5	-1.2
Relative age of first facial hair	0.1	0.2	0.9	-0.1	-0.9	0.2	-0.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.2	-0.0	-0.6	-1.8	-0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	0.4	0.4	-0.2	-0.1
Ever had hysterectomy (womb removed)	1.6	1.8	3.9	0.4	-2.0	-0.4	1.7
Systolic blood pressure, automated reading	0.4	1.1	2.8	0.2	-1.7	0.1	1.3
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.6	0.4	-1.1	-1.6	0.3
Angina	1.9	2.5	7.3	0.7	-1.3	-2.7	0.8
Medication for hormone replacement therapy	0.5	0.6	2.0	-0.3	-0.1	-0.2	-1.4
Vitamin and mineral supplements	0.6	0.8	1.6	0.7	1.3	0.4	1.0
Supplements: Zinc	0.4	0.4	1.4	0.2	-0.4	-0.4	1.2
Medication: Co-codamol	1.8	2.0	5.7	2.4	-0.8	-0.2	1.4
Medication: Metformin	0.6	0.8	2.4	0.0	-0.3	-1.6	0.8
Diabetes (father)	0.3	0.4	1.5	-0.4	0.2	1.2	-0.1
Diabetes (mother)	0.4	0.5	0.9	0.8	0.2	-1.0	0.6
Severe depression (siblings)	0.1	0.1	0.2	-0.3	0.3	-0.5	0.2
Pack years adult smoking proportion	1.3	1.9	4.3	1.0	-1.5	-2.1	0.3
Impedance of leg (right)	1.3	6.2	11.1	-2.4	1.9	-3.3	-2.1
Leg fat-free mass (left)	0.9	4.8	19.1	-0.5	0.1	4.4	0.0
Trunk fat percentage	0.1	0.3	0.7	0.8	-0.1	-0.0	0.8
Hand grip strength (right)	0.6	1.5	5.4	0.0	0.7	2.3	-0.4
Townsend deprivation index at recruitment	1.4	2.0	6.2	2.5	-0.2	-0.9	0.9
Current tobacco smoking	1.2	2.0	5.6	-1.2	0.9	-2.4	0.2
Average weekly fortified wine intake	0.7	0.8	1.8	-0.1	1.2	-0.1	-1.4
Maternal smoking around birth	0.4	0.5	1.9	0.3	1.4	0.3	-0.4
Fed-up feelings	1.5	2.7	9.6	-0.9	0.5	-3.1	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.9	-0.3	1.4	-0.5	2.0
Relative age voice broke	0.6	1.0	2.4	-0.3	-1.1	1.6	-0.3
Taking other prescription medications	0.2	0.3	0.6	-0.4	0.7	-0.0	0.7
Age when periods started (menarche)	0.6	1.5	3.1	-1.8	-0.6	-0.9	-1.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.4	0.5	-0.6	-1.2	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.9	-0.3	-0.3	0.5	2.0
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	3.8	-0.3	-0.0	-2.0	-0.7
Qualifications: CSEs or equivalent	0.8	1.1	4.2	-0.1	0.3	-2.1	-0.2
Serious illness, injury or assault to yourself	0.9	1.0	2.7	0.7	-1.6	-1.0	0.1
High blood pressure	0.4	1.2	2.4	0.1	-1.5	-1.2	1.1
Hayfever, allergic rhinitis or eczema	1.0	2.2	6.4	-2.5	1.4	-0.4	-0.4
Multivitamins +/- minerals	0.4	0.6	1.1	-0.8	-0.7	-0.2	-1.0
Stomach or abdominal pain in last month	0.0	0.1	0.1	-0.4	0.1	-0.1	0.2
Supplements: Glucosamine	0.6	0.8	2.6	-0.5	-0.5	0.1	-1.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	0.3	-0.2	-0.6	-0.6
Medication: Atenolol	1.6	1.9	3.9	-0.0	-1.1	-2.0	1.6
Medication: Levothyroxine sodium	1.2	2.0	7.2	-0.3	-0.1	2.7	-0.7
Sitting height	1.6	11.1	26.4	-3.0	1.9	5.1	-2.3
Chronic bronchitis/emphysema (father)	0.7	0.8	1.3	1.1	0.3	1.0	1.0
High blood pressure (mother)	0.2	0.2	0.5	-0.7	0.5	-0.2	-0.1
Body mass index (BMI)	0.3	1.4	3.9	1.1	-0.5	-0.3	2.0
Impedance of leg (left)	1.0	5.0	9.0	-2.4	1.6	-3.0	-1.6
Leg predicted mass (left)	0.9	4.6	18.3	-0.4	0.0	4.3	0.0
Trunk fat mass	0.1	0.5	1.7	0.1	0.2	1.3	0.7
Waist circumference	0.4	1.6	3.1	0.6	0.6	1.6	1.8
Number of incorrect matches in round	1.7	2.8	6.2	-1.7	1.2	-2.5	-0.8
Past tobacco smoking	2.5	4.7	15.3	0.7	0.3	-3.9	-1.7
Alcohol usually taken with meals	2.2	3.5	7.2	-1.7	0.8	2.7	-1.9
Nervous feelings	0.6	1.1	2.9	-1.7	0.8	0.9	-0.2
Frequency of tenseness / restlessness in last 2 weeks	2.5	3.9	7.7	-2.8	1.6	-2.0	1.1
Hearing difficulty/problems with background noise	0.1	0.2	0.4	0.6	-0.2	-0.3	-0.6
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	-0.8	0.2	0.7	0.1
Had menopause	1.7	2.1	3.8	1.4	-0.3	1.6	1.9
Had other major operations	1.6	1.9	5.0	-0.8	2.2	-0.8	-1.2
Forced vital capacity (FVC)	0.6	2.5	7.2	-1.5	0.8	2.7	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.4	0.5	-0.1	-0.0	1.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.7	0.0	0.8	-0.0	0.7
Qualifications: None of the above	2.4	5.1	9.4	1.6	-3.1	0.2	2.9
Financial difficulties in last 2 years	0.6	0.7	1.8	-1.1	-0.2	-1.3	0.0
Mouth/teeth dental problems	2.9	4.4	7.6	-1.2	1.8	2.3	2.8
Heart attack	4.7	6.1	15.3	0.9	-2.9	-3.9	0.2
Allergy	0.5	1.2	2.6	1.6	0.2	1.5	0.1
Pain all over the body in last month	0.6	0.7	1.5	-0.4	0.6	-0.8	1.2
Diabetes (self-reported)	0.1	0.2	0.3	0.6	-0.6	0.1	-0.4
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.4	-0.8	0.7	-1.8	0.5
Medication: Ramipril	1.6	2.1	6.9	0.5	-1.1	-2.6	-0.3
Medication: Simvastatin	1.7	2.4	8.0	0.8	-0.7	-2.8	0.7
Fluid intelligence score	0.9	1.8	5.2	-1.1	0.3	2.3	-0.8
Illnesses of siblings	0.9	1.2	4.3	0.3	-0.6	-2.1	0.3
Neuroticism score	0.5	1.0	1.6	-0.6	1.2	-0.6	-1.3
Weight	0.5	2.5	8.5	-0.6	0.8	2.9	0.6
Impedance of arm (right)	0.2	1.0	3.4	-0.3	0.5	-0.4	-1.9
Arm fat percentage (right)	0.3	1.4	3.0	1.4	-0.5	-0.5	1.7
Trunk fat-free mass	1.4	8.0	24.9	-2.2	1.4	5.0	-0.4
Hip circumference	0.5	2.0	2.8	-1.2	1.7	1.5	1.3
Time employed in main current job	0.6	0.7	1.7	0.0	-1.3	-0.1	-1.1
Alcohol intake versus 10 years previously	1.8	2.7	8.1	-1.1	-1.1	-2.8	-0.5
Father’s age at death	1.5	2.0	3.4	1.6	1.8	1.4	-0.4
Worrier / anxious feelings	0.2	0.4	0.6	0.7	0.7	0.6	0.3
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	2.8	-1.7	1.3	-1.5	-0.4
Falls in the last year	0.8	1.1	1.9	-0.5	-1.4	-1.2	0.9
Hair/balding pattern: Pattern 3	0.6	0.9	2.8	0.4	-0.7	-1.7	-0.3
Number of live births	0.6	0.8	2.1	-0.6	1.4	-0.0	-1.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	4.3	-1.5	0.3	2.1	-0.4
Pulse rate	0.5	0.8	2.5	-1.6	0.4	-0.5	-0.4
Happiness	0.2	0.2	0.7	-0.1	-0.8	-0.1	0.2
Noisy workplace	1.3	1.6	2.9	0.7	-1.7	-1.7	0.4
Qualifications: A levels/AS levels or equivalent	0.7	1.5	2.5	1.0	0.6	1.5	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.6	-0.5	-1.3	0.4	-0.6
Mouth/teeth dental problems: Dentures	1.3	2.2	5.4	0.7	-1.2	-2.3	-1.3
Asthma	0.6	1.2	2.2	-0.9	-1.3	-1.5	0.4
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	5.0	-2.2	0.7	-1.5	-1.9
Medication: Cholesterol lowering	1.9	3.0	7.1	0.6	-1.7	-2.7	1.2
Depression (self-reported)	1.9	2.2	3.9	1.7	1.4	-0.6	2.0
Medication: Lansoprazole	1.0	1.1	2.6	-1.6	0.7	-0.5	1.1
Prospective memory result	0.9	1.1	3.2	-0.4	0.9	-1.8	-0.1
Lung cancer (father)	0.2	0.3	0.7	-0.8	0.5	-0.4	0.2
Illnesses of mother	0.6	0.7	1.7	-0.6	1.3	0.9	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	3.3	-1.8	0.8	1.7	0.3
Pulse wave Arterial Stiffness index	0.5	0.6	0.9	0.5	-0.6	0.9	0.9
Impedance of arm (left)	0.3	1.2	3.6	-0.2	0.7	-0.7	-1.9
Arm fat mass (right)	0.2	0.8	1.8	0.4	0.1	1.1	1.3
Trunk predicted mass	1.3	7.7	23.8	-2.2	1.4	4.9	-0.5
Standing height	2.1	21.0	52.7	-3.9	2.8	7.3	-2.9
Length of working week for main job	1.9	2.1	7.2	0.3	-0.7	0.8	2.7
Exposure to tobacco smoke at home	0.4	0.4	1.1	0.5	-0.5	-1.1	-0.1
Breastfed as a baby	0.7	0.9	3.6	-0.2	0.1	1.9	-0.3
Tense / ‘highly strung’	0.3	0.5	1.0	-0.7	1.0	-0.3	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.8	-0.5	0.6	-0.3	0.9
Hair/balding pattern: Pattern 4	0.2	0.4	0.8	-0.1	-0.7	-0.9	0.5
Birth weight of first child	0.6	1.0	3.2	-0.0	-0.3	0.9	-1.8
Peak expiratory flow (PEF)	0.9	2.2	5.1	-0.9	-2.3	-1.1	-1.3
Pulse wave reflection index	1.0	1.2	2.6	1.6	-0.3	-0.2	1.5
Ever highly irritable/argumentative for 2 days	0.5	0.7	1.5	-0.4	1.2	-0.6	0.8
Loud music exposure frequency	0.9	1.0	2.9	0.5	0.5	1.7	0.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.9	0.4	0.4	-0.4	-2.0
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	5.0	-0.2	-0.6	-0.8	-2.2
Blood clot in the leg (DVT)	0.4	0.5	1.1	0.8	-0.2	0.1	1.0
Medication: Paracetamol	0.3	0.5	1.9	-1.4	-0.2	-0.5	0.2
Headache pain in last month	0.5	0.9	3.3	-0.4	1.8	0.0	0.1
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	4.0	-0.3	2.0	1.8	-1.2
Glaucoma (self-reported)	1.9	2.2	3.2	1.7	-1.8	-0.0	1.7
Gout (self-reported)	1.7	2.3	5.9	-2.4	1.1	-1.4	-0.1
Hypothyroidism/myxoedema (self-reported)	1.5	3.0	4.5	-1.1	1.3	2.1	-2.1
Medication: Amlodipine	1.1	1.5	3.6	0.9	-1.9	-1.3	-0.1
Medication: Ventolin 100micrograms inhaler	0.9	1.1	1.9	0.0	-1.4	-1.4	-0.7
Birth weight	1.0	2.2	3.3	-1.7	-1.3	-1.1	-1.8
Chronic bronchitis/emphysema (mother)	0.6	0.8	1.4	1.0	-1.2	-0.6	-0.6
High blood pressure (siblings)	0.2	0.3	1.1	-0.1	0.3	1.1	-0.1
Forced vital capacity (FVC), Best measure	0.8	3.0	7.7	-1.4	1.1	2.8	1.0
Body fat percentage	0.1	0.5	1.0	0.7	0.1	-0.8	1.0
Leg fat percentage (right)	0.3	1.2	3.8	0.0	0.7	-1.9	0.7
Arm fat-free mass (right)	0.8	4.3	13.5	-1.6	1.0	3.7	0.4
Exposure to tobacco smoke outside home	0.5	0.7	1.5	-1.2	0.5	-0.9	-0.3
Comparative body size at age 10	0.5	1.3	2.9	1.5	-0.1	-1.7	0.1
Number of full brothers	0.6	0.7	1.4	-0.8	0.7	1.2	-0.5
Worry too long after embarrassment	0.5	0.8	2.8	-0.4	1.7	0.5	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.2	-1.5	1.4	1.5	-0.4
Wheeze or whistling in the chest in last year	1.2	2.2	6.8	-1.2	-0.7	-2.6	-0.1
Number of children fathered	0.4	0.5	1.4	-0.4	-0.6	1.2	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.2	1.5	0.4	0.4	1.3
Age at first live birth	0.1	0.3	0.7	-0.9	-0.2	-0.2	0.4
Pulse wave peak to peak time	0.4	0.5	1.0	-0.6	0.7	-0.3	-1.0
Health satisfaction	3.3	4.3	8.6	-2.2	0.2	-2.9	-1.9
Shortness of breath walking on level ground	2.4	2.8	9.9	-0.4	-0.8	-3.1	-0.8
Qualifications: College or University degree	1.3	4.2	9.0	0.5	3.0	2.5	-1.0
Eye problems/disorders: None of the above	0.2	0.3	0.6	0.0	-0.3	0.5	-0.8
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.5	0.0	1.0	-1.2	0.5
Emphysema/chronic bronchitis	0.4	0.4	1.1	1.0	-0.5	-0.6	-0.1
Medication for pain relief, constipation, heartburn	2.4	4.1	11.9	1.0	1.9	3.4	0.5
Neck or shoulder pain in last month	0.7	1.1	3.3	0.6	-0.8	-0.1	1.8
Medication: Blood pressure	1.8	3.2	8.0	0.8	-2.8	-1.7	1.0
Angina (self-reported)	2.5	3.3	10.9	0.6	-1.1	-3.3	0.9
Migraine (self-reported)	0.8	1.0	2.1	1.2	-1.4	0.6	-0.4
Medication: Ibuprofen	2.9	3.4	7.1	-2.7	1.3	-1.3	-1.8
Medication: Allopurinol	1.7	2.3	7.2	-2.7	-0.2	-1.2	0.7
Medication: Omeprazole	0.7	0.8	1.2	-0.0	-1.0	-1.1	1.1
Medication: Seretide 50 evohaler	1.5	1.7	3.0	-0.7	-1.6	-1.7	-1.0
Mean time to correctly identify matches	2.3	4.4	11.4	1.4	1.8	-1.0	3.4
Heart disease (mother)	0.3	0.4	0.7	0.5	-0.7	-0.8	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	5.7	-0.0	-0.2	-0.9	-2.4
Whole body fat mass	0.1	0.3	0.6	-0.0	0.1	0.7	0.8
Leg fat mass (right)	0.0	0.1	0.3	-0.3	0.3	0.0	0.5
Arm predicted mass (right)	0.9	4.5	13.5	-1.9	0.9	3.7	0.2
Pulse rate, automated reading	0.4	1.3	4.2	-0.8	0.5	-2.0	-0.3
Alcohol intake frequency.	0.6	1.4	4.4	-0.5	0.8	-2.1	0.6
Comparative height size at age 10	1.5	8.2	27.9	-1.8	1.3	5.3	0.1
Number of full sisters	0.9	1.1	3.1	-0.7	0.8	-1.8	0.2
Suffer from ‘nerves’	0.1	0.2	0.4	-0.6	-0.1	0.2	0.5
Overall health rating	1.0	2.2	8.4	-0.1	-0.8	-2.9	0.2
Chest pain or discomfort	1.1	1.6	4.4	0.4	-0.7	-2.1	1.2
Had major operations	0.5	0.6	1.9	0.2	-1.4	0.5	-0.5
Age at last live birth	0.6	0.8	1.1	-1.1	-0.7	1.0	0.8
Family relationship satisfaction	0.9	1.1	2.5	0.6	0.3	-1.6	-1.1
Leg pain on walking	0.5	0.6	2.0	-0.6	0.2	-1.4	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.1	-0.4	0.0	-0.5
Commuting to job workplace: Car/motor vehicle	1.3	1.5	5.6	-0.2	0.2	-0.6	-2.4
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.3	0.1	0.8	0.8	1.1
Medication: Aspirin	4.7	6.1	10.5	0.4	-3.0	-3.2	2.2
Supplements: Vitamin C	1.0	1.2	2.4	-1.2	-0.2	-1.5	0.8
Knee pain experienced in last month	0.8	1.2	4.7	0.3	-0.4	-2.2	0.2
Hypertension (Self-reported)	0.6	1.5	2.8	0.5	-1.7	-1.0	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.2	0.9	0.2	0.9	1.5
Illnesses of father: Heart disease	2.2	3.1	8.7	0.4	-3.0	-1.6	1.0
Illnesses of siblings: Diabetes	1.4	1.7	4.2	-0.7	2.1	1.4	-0.5
Smoking status: Previous	3.2	4.8	17.1	-0.2	-0.5	4.1	1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.9	2.0	4.7	-2.2	0.7	1.6	-0.1
Whole body fat-free mass	1.2	6.6	23.7	-1.5	0.8	4.9	-0.1
Leg fat-free mass (right)	1.0	5.3	21.0	-0.4	-0.1	4.6	0.3
Arm fat percentage (left)	0.3	1.3	2.7	1.4	-0.3	-0.6	1.6
Average weekly red wine intake	3.2	4.7	11.8	-0.4	1.9	3.4	-1.7
Handedness (chirality/laterality): Left-handed	2.9	3.5	6.9	2.6	-1.9	1.3	-1.3
Mood swings	1.1	2.0	6.0	-0.7	0.4	-2.5	-1.1
Loneliness, isolation	1.3	1.8	5.4	-0.6	0.2	-2.3	-1.1
Long-standing illness, disability or infirmity	1.6	2.5	8.3	-0.0	-1.2	-2.9	0.5
Ever had bowel cancer screening	2.3	2.7	8.5	0.8	-1.2	2.9	0.3
Diabetes diagnosed by doctor	0.0	0.1	0.1	-0.1	-0.3	-0.3	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	0.2	0.8	-0.4	0.7
Friendships satisfaction	0.4	0.6	1.9	-1.4	0.4	-0.2	-0.3
Qualifications: nursing, teaching	0.9	1.4	5.0	0.1	2.2	-0.7	-0.2
Commuting to job workplace: Walk	0.5	0.5	1.2	-0.5	0.8	0.0	1.1
Eye problems/disorders: Cataract	0.3	0.4	1.0	1.0	0.1	-0.2	0.7
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.4	1.4	-0.4	1.6	-0.8
Medication for cholesterol	0.4	0.5	1.2	-0.8	-0.4	1.1	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.3	0.2	-0.4	-1.5	-0.3
Back pain experienced in last month	1.3	1.8	4.1	0.3	0.6	-2.0	1.7
Mineral and other dietary supplements	1.8	2.4	5.6	2.4	1.4	1.3	0.5
Breast cancer (self-reported)	1.3	1.6	2.6	0.9	-1.0	1.4	1.6
Asthma (self-reported)	0.6	1.3	2.7	-0.9	-1.3	-1.6	0.3
Osteoporosis (self-reported)	1.6	2.0	3.9	-1.3	2.0	0.8	1.3
Osteoarthritis (self-reported)	1.1	1.5	2.3	-1.5	-1.4	-1.1	-0.7
Medication: Aspirin	4.6	5.9	11.6	0.4	-3.0	-3.4	1.8
Medication: Gliclazide	0.5	0.5	1.3	1.1	0.3	0.1	0.9
Illnesses of father: None of the above (group 1)	0.6	0.8	1.8	-0.6	1.3	0.8	-0.5
Smoking status: Current	0.7	1.1	3.5	-0.6	0.8	-1.9	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.6	0.3	-1.3	0.4	0.2
Whole body water mass	1.1	6.2	21.9	-1.4	0.8	4.7	0.0
Leg predicted mass (right)	1.0	5.2	20.6	-0.4	-0.1	4.5	0.2
Arm fat mass (left)	0.2	0.7	1.7	0.5	-0.2	0.9	1.3
Number of self-reported non-cancer illnesses	0.9	1.6	3.9	-0.1	-2.0	-1.5	0.3
Average weekly champagne plus white wine intake	0.7	1.0	1.9	-1.4	0.2	1.2	0.7
Miserableness	1.2	2.0	3.4	1.1	0.2	-1.8	-1.9
Guilty feelings	0.4	0.6	1.2	0.4	1.1	1.0	0.2
Wears glasses or contact lenses	0.2	0.3	0.3	-0.6	-0.5	0.6	-0.4
Ever taken oral contraceptive pill	0.6	0.7	1.5	-1.2	0.8	0.8	0.0
Hearing aid user	2.3	2.6	3.7	-1.9	1.4	-1.8	-1.3
Mother’s age at death	0.9	1.1	2.6	1.2	-1.6	0.7	0.1
Financial situation satisfaction	0.3	0.3	0.9	0.4	0.4	-0.3	1.0
Tinnitus: Yes, now most or all of the time	4.1	4.7	7.5	2.3	-2.7	-2.0	-1.5
Commuting to job workplace: Public transport	0.5	0.6	0.7	0.8	0.7	0.8	0.7
Eye problems/disorders: Glaucoma	0.9	1.0	3.5	0.7	-0.3	0.1	1.9
Medication: Blood pressure	0.2	0.4	0.6	0.8	0.5	-0.5	0.6
Pain type(s) experienced in last month: Hip pain	2.7	3.4	9.4	0.5	2.0	-3.1	0.0
Supplements: Fish oil (including cod liver oil)	1.9	2.5	4.9	-2.2	-1.0	-1.6	-1.2
High cholesterol (Self-reported)	2.9	5.1	9.2	2.3	-1.7	-3.0	1.8
Medication: Bendroflumethiazide	2.0	3.1	5.9	1.7	-2.4	-1.1	-1.4
Medication: Paracetamol	0.5	0.8	3.0	-1.7	0.3	-0.4	-0.0
Medication: Lisinopril	0.2	0.3	1.1	-0.3	0.2	1.0	-0.3
Medication: Atorvastatin	3.1	3.9	9.0	1.7	-3.0	-0.6	1.8
Illnesses of father: High blood pressure	0.5	0.6	1.3	0.8	0.4	-1.1	-0.4
Alcohol drinker status: Never	0.6	0.7	2.4	-0.1	1.6	0.3	0.5
Ever smoked	2.3	4.1	8.4	-1.3	0.1	2.9	2.5
Basal metabolic rate	0.9	5.2	18.2	-1.4	0.9	4.3	0.1
Leg fat percentage (left)	0.3	1.0	2.9	-0.0	0.5	-1.7	0.9
Arm fat-free mass (left)	0.9	4.8	16.0	-1.4	0.9	4.0	0.5
Number of operations (self-reported)	0.3	0.5	1.4	-1.2	0.3	0.2	-0.6
Average weekly beer plus cider intake	1.0	1.4	5.1	-0.3	0.7	-2.3	-0.0
Irritability	0.5	0.9	1.2	-1.1	0.7	-0.9	-1.0
Risk taking	2.0	2.9	4.9	-2.2	2.0	1.0	-1.3
Ever had prostate specific antigen (PSA) test	1.1	1.3	4.1	-0.2	-0.7	2.0	-0.7
Fractured/broken bones in last 5 years	2.4	3.2	11.6	-3.4	0.7	0.1	-0.7
Age started oral contraceptive pill	0.6	0.8	2.0	-0.2	0.7	1.4	0.8
Diastolic blood pressure, automated reading	0.1	0.2	0.5	-0.1	0.4	-0.7	0.1
Ever depressed for a whole week	0.3	0.4	1.0	0.2	-1.0	-0.2	0.6
Unable to work because of sickness or disability	2.3	2.9	7.4	0.5	-1.6	-2.7	1.2
Commuting to job workplace: Cycle	0.7	0.9	2.7	0.8	0.1	-0.4	1.6
Myopia	1.0	1.4	5.3	2.3	-0.2	0.4	-0.2
Vascular/heart problems diagnosed by doctor	1.1	3.1	6.7	-0.4	2.6	2.0	-1.1
Cholesterol lowering medication	0.9	1.4	3.0	1.7	-0.3	-1.2	1.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	0.2	-0.9	-0.8	0.2
Pain experienced in last month	1.7	2.8	7.4	-0.8	-0.1	1.7	-2.7
Supplements: Calcium	0.4	0.5	1.1	-1.1	0.2	0.3	0.9
Basal cell carcinoma (self-reported)	1.1	1.3	2.5	0.4	1.5	1.6	-0.6
Heart attack/myocardial infarction (self-reported)	5.1	6.6	16.3	1.1	-3.0	-4.0	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.8	1.3	-0.6	-0.3	0.9
Heart disease (siblings)	0.7	0.9	2.7	-0.9	-1.7	-0.4	-0.1
Alcohol drinker status: Previous	1.6	1.8	2.8	-1.1	1.7	-0.6	1.6
Pack years of smoking	1.4	2.0	4.0	1.2	-1.6	-2.0	0.1
Impedance of whole body	0.5	2.4	3.5	-1.1	1.1	-1.9	-1.9
Leg fat mass (left)	0.1	0.2	0.6	-0.3	0.3	0.3	0.8
Arm predicted mass (left)	0.9	4.8	15.6	-1.4	1.0	4.0	0.7