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chr7:871,369-3,581,391

Best TWAS P=4.07e-118 · Best GWAS P=1.05e-118 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
28	ROSMAP	Brain Pre-frontal Cortex	AMZ1	0.09	0.05	lasso	6	0.04	2.4e-06	-23.15	23.1	4.1e-118	-0.95	0.01	0.99	TRUE
33	The Cancer Genome Atlas	Esophageal Carcinoma	AMZ1	0.18	0.05	blup	69	0.05	1.4e-02	11.95	-18.2	3.3e-74	0.74	0.01	0.71	TRUE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	AMZ1	0.04	0.04	lasso	3	0.02	1.3e-03	11.95	14.4	3.2e-47	-0.64	0.04	0.90	TRUE
27	NTR	Blood	GNA12	0.07	0.03	bslmm	597	0.06	1.3e-17	-15.02	-14.4	4.0e-47	0.64	0.93	0.07	TRUE
1	CommonMind	Brain Pre-frontal Cortex	AMZ1	0.19	0.12	enet	22	0.13	5.7e-16	11.72	13.1	4.4e-39	-0.44	1.00	0.00	TRUE
22	GTEx	Skin Sun Exposed Lower leg	AC004840.9	0.18	0.01	enet	36	0.02	3.7e-03	4.43	-7.9	2.5e-15	0.13	0.20	0.13	TRUE
16	GTEx	Lung	SNX8	0.14	0.01	lasso	6	0.04	4.1e-04	-1.28	7.3	3.4e-13	-0.29	0.25	0.13	TRUE
29	YFS	Blood	CHST12	0.04	0.00	enet	25	0.02	1.0e-06	-1.94	6.2	4.9e-10	-0.15	0.04	0.04	TRUE
19	GTEx	Prostate	MAFK	0.43	-0.01	enet	22	0.01	1.8e-01	5.03	-5.8	5.9e-09	0.02	0.02	0.50	TRUE
13	GTEx	Esophagus Muscularis	MAD1L1	0.22	0.01	enet	40	0.05	5.6e-04	-3.42	-5.6	2.7e-08	-0.03	0.18	0.13	TRUE
7	GTEx	Cells EBV-transformed lymphocytes	GNA12	0.46	0.51	lasso	5	0.50	7.9e-19	-22.72	-22.7	3.1e-114	0.93	0.60	0.40	FALSE
14	GTEx	Esophagus Muscularis	GNA12	0.32	0.31	lasso	3	0.34	2.1e-21	-23.15	-22.6	3.3e-113	0.97	0.00	1.00	FALSE
25	GTEx	Whole Blood	GNA12	0.09	0.01	enet	4	0.00	3.3e-01	-22.11	-22.4	2.8e-111	0.95	0.02	0.93	FALSE
12	GTEx	Esophagus Mucosa	GNA12	0.16	0.13	lasso	3	0.13	3.0e-09	-22.75	-21.7	8.6e-105	0.89	0.02	0.98	FALSE
6	GTEx	Artery Tibial	GNA12	0.24	0.13	enet	20	0.22	3.5e-17	-23.15	-21.5	6.8e-103	0.87	0.02	0.98	FALSE
9	GTEx	Colon Sigmoid	GNA12	0.14	0.05	lasso	3	0.03	3.6e-02	-15.93	-20.4	6.4e-93	0.84	0.03	0.90	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	GNA12	0.20	0.12	lasso	6	0.12	3.4e-05	-16.37	-20.4	8.2e-93	0.85	0.04	0.94	FALSE
18	GTEx	Nerve Tibial	GNA12	0.31	0.34	lasso	7	0.36	9.6e-27	-16.18	-20.0	2.0e-89	0.86	0.90	0.10	FALSE
21	GTEx	Skin Sun Exposed Lower leg	GNA12	0.17	0.16	lasso	3	0.18	1.3e-14	-15.85	-20.0	2.4e-89	0.88	0.10	0.90	FALSE
8	GTEx	Cells Transformed fibroblasts	GNA12	0.21	0.11	lasso	11	0.15	1.7e-11	-23.10	-19.4	3.1e-84	0.89	0.02	0.98	FALSE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	GNA12	0.03	0.01	enet	7	0.02	1.5e-03	11.32	-19.3	1.3e-82	0.77	0.06	0.75	FALSE
17	GTEx	Lung	GNA12	0.16	0.08	enet	21	0.12	1.2e-09	-22.71	-18.9	6.5e-80	0.78	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	GNA12	0.11	0.08	lasso	4	0.07	1.3e-06	-16.37	-17.1	2.0e-65	0.73	0.67	0.33	FALSE
26	METSIM	Adipose	GNA12	0.07	0.05	lasso	3	0.05	3.3e-08	-16.19	-16.4	9.8e-61	0.74	0.26	0.74	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GNA12	0.03	0.04	lasso	1	0.04	3.0e-05	-16.37	-16.4	3.0e-60	0.70	0.08	0.76	FALSE
23	GTEx	Small Intestine Terminal Ileum	GNA12	0.34	0.20	lasso	5	0.16	2.4e-04	-16.19	-16.3	1.3e-59	0.73	0.08	0.75	FALSE
10	GTEx	Colon Transverse	GNA12	0.19	0.08	lasso	4	0.10	2.3e-05	14.40	-16.0	8.2e-58	0.64	0.24	0.74	FALSE
24	GTEx	Stomach	GNA12	0.18	0.16	lasso	2	0.13	6.6e-07	-15.93	-16.0	9.4e-58	0.69	0.76	0.22	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	AMZ1	0.08	0.01	blup	71	0.05	1.3e-05	-16.37	13.0	1.5e-38	-0.64	0.05	0.75	FALSE
30	YFS	Blood	GNA12	0.23	0.15	bslmm	570	0.25	4.5e-82	7.69	-12.5	1.4e-35	0.51	1.00	0.00	FALSE
15	GTEx	Liver	AC004840.9	0.27	0.01	enet	27	0.06	7.0e-03	0.95	12.2	1.7e-34	-0.37	0.07	0.20	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	GNA12	0.10	0.15	lasso	3	0.12	4.2e-07	10.59	-12.2	2.6e-34	0.53	0.32	0.67	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	AMZ1	0.32	0.04	enet	19	0.20	3.3e-19	-15.02	11.8	2.9e-32	-0.57	0.17	0.83	FALSE
32	The Cancer Genome Atlas	Colon Adenocarcinoma	GNA12	0.09	0.00	blup	103	0.03	9.3e-03	-16.18	-10.5	9.5e-26	0.51	0.04	0.11	FALSE
38	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	AMZ1	0.17	0.11	enet	9	0.10	5.0e-05	4.29	9.7	2.2e-22	-0.47	0.05	0.44	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AMZ1	0.14	0.06	enet	15	0.06	7.4e-08	4.29	8.4	6.2e-17	-0.33	0.84	0.04	FALSE
2	CommonMind	Brain Pre-frontal Cortex	GNA12	0.06	0.00	bslmm	603	0.02	3.7e-03	0.59	8.4	6.5e-17	-0.44	0.12	0.09	FALSE
4	GTEx	Adipose Visceral Omentum	GNA12	0.28	0.06	enet	46	0.08	8.0e-05	10.59	-7.2	4.0e-13	0.38	0.11	0.74	FALSE
5	GTEx	Adrenal Gland	GNA12	0.33	-0.01	enet	41	0.10	1.6e-04	2.83	-5.9	3.1e-09	0.22	0.06	0.27	FALSE
31	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TMEM184A	0.03	0.01	lasso	2	0.02	1.5e-02	5.11	5.3	1.1e-07	-0.04	0.01	0.68	FALSE