Hub : Genes

SNX8

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Colon Transverse 0.2840 0.0850 7.4e-04 0.273 NA 0.213 NA 0.251 2.4e-13 NA 1.8e-10 NA 2.9e-12
2 GTEx Esophagus Mucosa 0.1660 0.0660 8.4e-03 0.094 NA 0.055 NA 0.090 7.9e-07 NA 1.5e-04 NA 1.2e-06
3 GTEx Lung 0.1382 0.0513 5.9e-04 0.006 NA 0.034 NA 0.041 1.0e-01 NA 1.2e-03 NA 4.1e-04
4 GTEx Testis 0.4080 0.0830 2.9e-06 0.310 NA 0.314 NA 0.304 2.6e-14 NA 1.7e-14 NA 5.4e-14
5 GTEx Thyroid 0.1380 0.0420 2.3e-05 0.090 NA 0.095 NA 0.107 2.3e-07 NA 1.0e-07 NA 1.6e-08
6 ROSMAP Brain Pre-frontal Cortex 0.0916 0.0275 5.0e-06 0.044 0.046 0.041 0.044 0.040 2.0e-06 1.2e-06 4.7e-06 2.2e-06 7.0e-06
7 YFS Blood 0.0328 0.0108 1.4e-05 -0.001 0.015 0.010 0.014 0.004 7.0e-01 6.6e-06 3.0e-04 1.4e-05 1.2e-02
8 TCGA Colon Adenocarcinoma 0.1480 0.0780 6.1e-03 0.073 0.040 0.051 NA 0.060 5.2e-05 2.2e-03 6.7e-04 NA 2.3e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 2.6 4.2 7.4 1.9 2.6 -1.1 1.5 2.7 -2.2 -1.4 2.3
Bipolar Disorder or Schizophrenia 2.7 6.6 16.2 1.8 2.2 -3.4 1.0 3.4 -4.0 -0.8 2.0
Depressed Affect (Nagel 2018) 2.1 4.4 7.8 -2.1 -1.8 1.9 -1.8 -2.1 2.8 1.9 -2.2
Depression (Nagel 2018) 0.6 0.9 2.5 -1.2 -0.5 0.2 -0.8 -0.6 0.8 1.6 -1.3
Intelligence (Savage-Jansen 2018) 0.7 2.3 8.0 -1.4 -0.8 2.8 -1.5 -1.7 -0.3 0.1 -1.6
Neuroticism (Nagel 2018) 1.2 2.8 12.6 -0.8 -0.3 1.2 -0.9 -2.0 3.5 1.6 -0.8
Schizophrenia (2018) 1.7 3.6 12.0 0.8 0.7 -3.2 0.0 2.2 -3.5 0.2 0.8
Schizophrenia vs Biploar Disorder 0.6 0.7 2.3 -0.3 -0.7 -1.5 -0.7 0.8 -1.1 0.7 -0.1
Worry (Nagel 2018) 0.5 1.1 5.5 0.4 0.7 -0.6 -0.1 -0.8 2.3 1.4 0.3
Alzheimer’s Disease (in mother) 0.4 0.5 2.1 0.6 1.4 -0.3 0.3 0.4 -1.0 -0.5 0.3
Alzheimer’s Disease (in father) 1.3 1.4 6.0 -0.3 -0.7 -2.0 -0.2 2.5 -0.4 -0.6 -0.4
Alzheimer’s Disease (including proxy) 0.5 0.7 2.1 0.1 0.4 -1.0 -0.2 1.4 -1.4 -0.5 -0.2
Crohns Disease (2017) 0.0 0.1 0.3 -0.5 -0.4 -0.1 -0.5 0.2 -0.0 -0.3 -0.3
Irritable Bowel Disease (IBD) 0.2 0.4 1.1 0.1 -0.5 1.0 -0.2 0.8 -1.0 0.1 0.2
Ulcerative Colitis (UC) 0.7 1.2 3.4 0.8 -0.0 1.8 0.6 1.1 -1.8 -0.3 0.9
Major Depression (MDD) 1.0 1.3 3.8 0.0 -1.3 0.8 -0.9 0.0 1.7 1.9 0.0
Reaction Time 1.0 1.9 3.8 1.5 1.6 -1.9 1.5 1.1 -1.1 -0.2 1.3
Verbal and Numeric Reasoning (VNR) 0.7 1.6 4.7 -0.5 -0.2 2.2 -0.9 -1.9 1.7 -0.5 -0.6
Breast Cancer 0.3 0.7 2.2 -0.9 -0.3 -0.5 -0.6 0.5 -1.5 0.4 -1.1
Ovarian Cancer 0.2 0.3 1.3 0.8 1.1 -0.2 0.2 0.5 -0.4 0.1 -0.1
Prostate Cancer 1.3 1.8 5.4 -1.5 -0.5 0.0 -2.3 -1.2 1.1 0.1 -2.0
Age at First Birth 0.5 0.7 3.6 -0.3 0.8 0.4 0.0 0.6 -1.9 -0.8 -0.6
Bipolar Disorder (2011) 0.3 0.3 2.7 0.0 0.0 0.0 0.0 0.0 0.0 -1.6 0.0
Body Mass Index (BMI) (2010) 1.2 1.6 3.2 -1.2 -1.4 0.8 -1.1 -1.8 0.2 1.5 -1.4
Coronary Artery Disease (CAD) 0.3 0.4 1.6 1.0 0.7 0.4 1.3 -0.3 -0.0 0.1 0.0
Crohns Disease (2012) 0.2 0.4 1.3 0.3 0.3 -0.9 0.4 1.2 -0.6 -0.3 0.5
Mean Putamen Volume 0.7 0.8 1.6 1.2 0.9 1.3 0.9 -0.5 0.1 -0.0 1.2
Fasting Glucose 0.9 1.1 3.2 -0.5 -1.0 1.8 -0.3 -0.8 0.1 1.6 -0.9
HbA1C 3.6 4.0 9.5 2.1 1.9 -0.2 2.0 0.4 2.5 -3.1 2.0
HDL Cholesterol 0.4 0.7 3.6 0.2 0.5 0.1 0.7 0.1 1.9 -1.1 0.4
LDL Cholesterol 0.4 0.6 2.8 0.3 -0.0 -0.3 0.5 -0.4 1.7 -0.9 0.5
Lupus 1.2 1.8 3.2 1.8 1.8 0.7 1.5 0.0 -1.5 0.5 1.6
Neuroticism (2016) 1.6 2.4 9.6 -0.8 -1.0 2.0 -0.3 -1.8 3.1 -0.1 -0.5
Primary Biliary Cirrhosis 1.2 1.7 4.4 1.9 1.3 -0.4 1.5 0.6 -0.7 0.7 2.1
Rheumatoid Arthritis 1.3 1.7 3.4 1.8 1.1 1.0 1.5 -0.4 1.6 -0.2 1.8
Schizophrenia (2014) 2.7 6.1 15.7 1.8 1.7 -4.0 1.0 3.3 -3.3 -0.1 2.0
Triglycerides 1.4 2.3 4.2 2.0 1.6 -0.9 1.6 1.2 -1.0 -1.3 2.0
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.3 0.5 0.9 0.5 0.9 -0.8 1.1 0.4 0.6
Ulcerative Colitis 0.7 1.0 4.6 0.8 -0.1 0.7 0.0 1.0 -2.2 0.7 0.7
Blood Eosinophil Count 1.1 8.6 17.5 3.6 3.5 -2.7 4.2 0.9 1.2 -2.1 3.5
Blood Platelet Count 0.6 6.7 20.1 -2.4 -2.0 -2.7 -1.2 -1.9 2.5 4.5 -2.2
Blood Red Count 0.6 6.2 13.5 3.0 3.2 -1.8 3.7 0.2 1.6 0.7 3.2
Blood White Count 1.8 13.5 23.7 4.9 4.4 -3.0 4.8 -1.1 3.0 0.8 4.6
Heel T-Score 0.5 4.2 8.2 2.1 2.5 -2.9 2.1 1.1 0.6 -2.0 2.2
BMI 0.6 3.7 8.9 -1.6 -1.0 1.4 -1.0 -2.2 2.2 3.0 -2.2
Height 1.1 21.3 78.0 -0.2 -1.0 8.8 -2.3 3.2 -6.7 -5.5 -0.3
Waist Hip Ratio (WHR) 0.7 3.0 5.7 2.1 2.3 -2.1 1.2 1.0 0.8 -0.9 2.4
Systolic Blood Pressure 0.4 2.3 5.4 0.8 -0.2 -2.3 1.2 1.6 -1.0 2.3 1.3
Smoking Status 0.7 1.6 4.0 -1.4 -1.0 0.6 -1.4 -1.2 0.1 1.3 -2.0
Allergy or Eczema 0.9 2.3 4.8 2.2 2.2 1.7 1.5 0.5 -0.5 -0.8 1.7
Cardiovascular Disease 0.8 2.6 10.8 -0.2 -0.2 -2.3 0.9 -0.6 3.3 1.8 0.1
Hypothyroidism (self reported) 1.8 4.1 5.8 1.8 2.4 -2.3 2.4 2.1 1.1 -2.3 1.5
Respiratory disease 0.1 0.2 0.8 -0.3 -0.3 -0.4 -0.2 0.2 -0.0 0.9 -0.5
Type 2 Diabetes (T2D) (2018) 0.1 0.3 1.0 0.0 1.0 0.1 -0.2 -0.1 0.3 1.0 -0.1
Lung FEV1/FVC ratio 0.4 2.3 8.1 -1.2 -1.3 -2.8 -0.8 1.1 -0.0 1.6 -1.6
Lung FVC 0.4 2.1 6.1 -1.4 -1.2 1.6 -0.6 -2.5 0.8 1.4 -1.5
Neuroticism 1.1 2.7 9.1 -1.0 -0.8 1.7 -0.7 -2.2 3.0 1.3 -0.8
Chronotype (morning person) 0.3 0.8 3.6 -0.3 -0.9 1.9 0.2 -0.8 0.9 -0.2 0.2
Hair Pigment 0.0 1.4 7.1 -0.5 -0.3 0.3 0.1 -0.4 -2.7 1.8 -0.4
Tanning 0.1 0.9 3.0 -0.1 0.1 0.4 0.2 -1.4 1.5 -1.7 -0.0
Hand grip strength (left) 0.3 0.8 1.9 -0.6 -0.3 0.1 -1.3 1.4 -0.7 -0.9 -0.8
Number of treatments/medications taken 3.0 5.3 11.7 -2.0 -2.5 2.3 -1.2 -3.1 3.4 1.0 -1.8
Average weekly spirits intake 1.2 1.5 3.9 -0.7 -0.8 -1.9 -0.6 2.0 -1.6 -0.6 -0.3
Sensitivity / hurt feelings 0.6 1.1 6.8 0.0 0.1 1.0 -0.1 -0.9 2.6 0.4 -0.1
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.2 -0.9 -0.4 1.1 -0.3 0.2 -0.4 0.6 -0.7
Hearing difficulty/problems: Yes 5.8 8.9 14.1 -3.1 -3.1 3.1 -3.1 -3.1 0.0 3.8 -2.9
Relative age of first facial hair 0.8 1.6 7.0 0.4 0.6 1.2 0.6 -0.1 -2.6 1.8 0.5
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 4.0 -0.6 -1.2 1.3 -0.5 -1.3 -0.5 2.0 -0.6
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.9 -0.6 -0.5 0.7 -0.6 0.2 1.0 -0.7 -0.7
Ever had hysterectomy (womb removed) 2.3 2.5 3.8 -1.4 -1.8 1.5 -1.5 -1.8 -1.9 1.5 -1.1
Systolic blood pressure, automated reading 0.8 2.3 7.3 0.4 -0.1 -1.0 0.4 1.6 -2.6 2.7 0.7
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 2.7 0.4 0.7 -1.6 0.4 0.5 -1.1 0.7 0.3
Angina 1.4 1.9 7.4 -0.1 -0.6 1.2 0.2 -2.4 2.7 0.0 0.1
Medication for hormone replacement therapy 0.2 0.2 1.1 0.1 0.0 0.4 0.3 0.4 -0.4 -1.0 -0.1
Vitamin and mineral supplements 0.8 1.1 3.2 -0.8 -0.6 1.0 -0.9 -1.5 1.8 0.7 -0.7
Supplements: Zinc 1.3 1.4 5.5 -0.2 -0.0 2.3 -0.2 -0.7 -2.3 -0.3 -0.1
Medication: Co-codamol 1.3 1.5 7.0 -0.2 -1.5 0.2 -0.5 -1.5 -0.7 2.6 -0.2
Medication: Metformin 0.2 0.3 1.4 0.3 1.2 -0.1 0.2 0.3 -0.5 0.6 0.3
Diabetes (father) 1.2 1.5 5.1 1.1 0.5 -0.4 1.0 1.7 -0.4 -2.3 1.1
Diabetes (mother) 0.8 1.0 2.7 1.6 0.9 -0.3 1.6 -0.3 0.3 -0.0 1.4
Severe depression (siblings) 0.3 0.4 0.7 -0.4 -0.5 -0.8 -0.6 0.1 -0.6 0.9 -0.6
Pack years adult smoking proportion 0.6 1.0 3.2 0.4 -0.1 0.2 0.8 -1.8 1.5 1.0 0.5
Impedance of leg (right) 0.4 2.2 5.2 1.8 0.7 -0.4 1.5 0.8 -1.5 -1.7 2.3
Leg fat-free mass (left) 1.1 6.0 20.0 -2.6 -1.6 4.5 -2.9 -1.0 -0.0 0.4 -3.0
Trunk fat percentage 2.8 11.2 17.7 -3.5 -2.9 3.7 -3.5 -3.5 -0.3 4.2 -3.6
Hand grip strength (right) 0.5 1.3 4.2 0.8 0.9 0.2 0.0 1.8 -0.9 -2.1 0.5
Townsend deprivation index at recruitment 1.4 2.0 4.6 -1.7 -1.1 2.1 -1.3 -0.6 -1.3 0.2 -1.8
Current tobacco smoking 0.1 0.2 1.1 -0.0 -0.0 0.6 0.4 -1.1 0.0 0.0 -0.2
Average weekly fortified wine intake 0.2 0.3 0.5 -0.4 -0.6 0.4 -0.5 -0.7 0.1 0.7 -0.6
Maternal smoking around birth 0.3 0.4 1.3 0.4 0.2 -0.0 0.6 -0.8 0.5 1.1 0.5
Fed-up feelings 0.6 1.1 3.0 -0.7 -1.2 0.5 -0.3 -0.4 1.7 1.7 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.9 4.0 -1.8 -1.6 1.0 -1.2 -1.0 0.3 1.3 -2.0
Relative age voice broke 0.6 1.0 4.1 -0.0 0.3 2.0 0.2 -0.8 -1.5 0.9 -0.0
Taking other prescription medications 2.1 3.2 7.9 -0.8 -1.6 2.3 -0.7 -2.8 1.4 2.5 -1.0
Age when periods started (menarche) 0.2 0.5 1.2 -0.9 -0.2 0.4 -0.7 0.6 1.1 -0.3 -0.8
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 2.1 -0.7 -1.0 1.5 -0.4 -1.1 -0.0 0.5 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.5 -0.3 0.0 -1.2 -0.2 0.3 0.8 -0.8 0.3
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 2.8 -1.3 -1.7 1.5 -1.6 -0.5 0.1 0.9 -1.5
Qualifications: CSEs or equivalent 0.1 0.1 0.2 0.1 -0.3 0.2 0.4 0.1 0.2 0.3 0.3
Serious illness, injury or assault to yourself 0.1 0.1 0.3 -0.1 -0.0 -0.1 -0.0 0.0 0.6 0.6 -0.2
High blood pressure 0.7 2.0 6.5 -1.1 -1.6 -1.3 -0.2 -0.8 1.8 2.5 -0.7
Hayfever, allergic rhinitis or eczema 1.6 3.5 8.4 2.5 2.9 1.9 1.8 0.3 -1.2 -0.9 1.9
Multivitamins +/- minerals 1.5 1.9 7.3 1.0 1.0 -1.2 0.8 1.9 -2.7 -0.3 0.5
Stomach or abdominal pain in last month 0.7 0.9 2.0 -1.2 -1.4 0.8 -0.9 0.1 -0.6 1.1 -0.9
Supplements: Glucosamine 0.8 1.0 2.0 -1.1 -1.0 0.4 -1.4 0.3 -1.3 -0.3 -1.3
Diverticular disease/diverticulitis (self-reported) 1.8 2.1 2.9 -1.6 -1.5 1.5 -1.6 -1.7 1.4 -0.3 -1.5
Medication: Atenolol 0.8 0.9 2.9 -1.0 -0.8 0.2 -0.6 -1.5 1.7 0.4 -0.6
Medication: Levothyroxine sodium 1.9 3.2 5.3 1.9 1.7 -1.2 2.2 1.8 1.0 -2.3 1.7
Sitting height 1.5 10.6 63.2 -0.6 -0.5 8.0 -1.9 -0.2 -2.5 -3.1 -1.1
Chronic bronchitis/emphysema (father) 1.3 1.6 6.7 -0.1 0.2 0.5 -0.3 -2.3 2.6 0.5 -0.1
High blood pressure (mother) 0.2 0.3 1.5 -0.2 -0.1 -0.7 -0.1 0.1 1.2 0.5 -0.2
Body mass index (BMI) 1.7 7.2 13.2 -2.6 -1.9 1.6 -2.1 -3.4 2.7 3.6 -2.9
Impedance of leg (left) 0.4 2.1 5.0 1.7 0.5 -0.6 1.3 1.1 -2.2 -1.0 2.2
Leg predicted mass (left) 1.1 6.0 19.4 -2.6 -1.7 4.4 -2.9 -1.0 0.1 0.3 -3.1
Trunk fat mass 2.7 11.5 18.9 -3.7 -3.0 4.3 -3.8 -3.3 -0.1 3.4 -3.8
Waist circumference 1.2 4.2 8.2 -1.8 -1.4 2.9 -1.8 -2.6 1.2 2.3 -1.9
Number of incorrect matches in round 0.8 1.3 4.0 -1.4 -1.3 -0.2 -2.0 -0.9 0.4 -0.1 -1.3
Past tobacco smoking 0.8 1.6 3.3 1.3 1.0 -1.2 1.3 1.2 0.2 -1.3 1.8
Alcohol usually taken with meals 0.1 0.1 0.5 0.0 0.2 0.0 -0.1 0.1 -0.7 -0.5 -0.4
Nervous feelings 0.6 1.1 4.6 0.8 1.4 -0.7 0.1 -0.4 2.1 0.2 0.6
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 4.1 -0.5 -0.8 1.9 -0.2 -1.5 0.0 2.0 -0.7
Hearing difficulty/problems with background noise 4.9 7.9 10.9 -3.1 -2.5 2.9 -3.3 -2.8 -0.9 3.1 -3.1
Hair/balding pattern: Pattern 2 0.7 0.8 2.4 -0.4 -0.8 1.6 -0.6 -0.5 1.2 -1.1 -0.4
Had menopause 0.6 0.7 1.8 -0.7 -0.4 0.9 -1.3 -0.3 0.6 -1.1 -0.7
Had other major operations 0.1 0.1 0.3 0.1 -0.2 0.3 0.2 0.3 0.5 0.1 -0.0
Forced vital capacity (FVC) 0.6 2.2 11.6 -1.0 -1.0 3.4 -1.0 -0.5 -1.0 -0.6 -1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 2.8 0.5 0.5 -1.7 0.7 0.5 1.0 -1.2 0.9
Ever unenthusiastic/disinterested for a whole week 1.3 1.5 3.7 1.4 1.6 -0.5 1.3 0.1 1.3 -0.7 1.9
Qualifications: None of the above 2.5 5.3 13.1 -1.5 -2.7 2.0 -0.9 -3.6 3.1 2.0 -1.3
Financial difficulties in last 2 years 0.8 1.1 2.7 1.2 1.4 0.4 1.6 0.5 -0.5 1.1 1.0
Mouth/teeth dental problems 1.6 2.5 4.8 1.5 1.8 -2.2 1.5 0.5 0.4 -2.2 1.6
Heart attack 1.1 1.4 6.6 0.4 0.3 -0.1 1.3 -0.5 2.6 -1.3 1.0
Allergy 0.5 1.2 2.8 -1.4 -1.5 -1.7 -1.0 0.1 0.3 0.1 -1.0
Pain all over the body in last month 0.5 0.5 2.1 0.7 0.3 0.4 0.5 -0.6 -0.7 1.4 0.6
Diabetes (self-reported) 0.4 0.7 2.4 -0.5 0.2 0.6 -0.6 -1.0 0.8 1.6 -0.6
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 2.7 1.2 0.9 0.1 0.5 -0.7 1.7 -1.2 1.1
Medication: Ramipril 1.6 2.0 4.2 -2.0 -1.5 0.9 -1.4 -1.3 1.3 0.8 -1.6
Medication: Simvastatin 1.8 2.6 10.2 -1.7 -0.7 -0.2 -1.1 -1.9 3.2 0.6 -1.4
Fluid intelligence score 0.6 1.2 2.4 1.1 1.3 1.4 1.0 -0.2 0.6 -1.5 1.0
Illnesses of siblings 1.4 2.0 3.6 -1.7 -0.9 1.2 -1.9 -0.6 -1.9 0.2 -1.9
Neuroticism score 0.8 1.6 6.0 -0.4 -0.2 1.2 -0.0 -1.5 2.5 1.7 -0.2
Weight 1.7 8.3 21.2 -3.0 -2.4 4.6 -3.2 -2.3 0.4 1.9 -3.4
Impedance of arm (right) 0.8 3.7 25.2 0.5 0.4 0.5 -0.2 1.7 -5.0 0.5 0.6
Arm fat percentage (right) 2.0 8.0 19.4 -2.9 -2.3 1.9 -2.6 -3.1 1.1 4.4 -3.0
Trunk fat-free mass 0.8 4.6 15.7 -1.9 -1.8 4.0 -2.4 -0.3 0.6 -1.5 -2.4
Hip circumference 1.5 6.7 18.7 -2.7 -2.0 4.3 -2.5 -2.3 0.8 1.6 -3.0
Time employed in main current job 0.4 0.5 0.9 -0.8 -1.0 0.5 -0.7 -0.1 0.9 -0.0 -0.7
Alcohol intake versus 10 years previously 1.5 2.2 8.1 -0.6 -0.7 1.9 -0.1 -2.9 1.7 1.1 -0.8
Father’s age at death 0.7 0.9 2.6 -1.1 -0.3 0.3 -1.6 0.0 0.0 -0.9 -1.4
Worrier / anxious feelings 0.7 1.4 4.3 0.1 0.1 0.8 0.3 -1.6 2.1 1.8 0.1
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.4 4.4 -1.7 -1.5 2.1 -1.3 -1.2 0.9 1.6 -1.8
Falls in the last year 0.6 0.8 2.6 -0.9 -1.0 0.1 -0.7 -0.7 0.6 1.6 -0.9
Hair/balding pattern: Pattern 3 0.7 1.1 2.9 -0.4 -0.7 -1.7 -0.2 0.8 -1.5 1.5 -0.1
Number of live births 0.5 0.7 1.8 -1.2 -1.3 0.8 -0.8 -0.7 0.3 0.5 -0.5
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 5.1 -0.7 -1.0 2.2 -0.5 0.0 -0.9 -0.2 -1.1
Pulse rate 0.3 0.4 1.4 0.6 0.1 0.9 0.1 -0.4 -0.9 1.2 0.4
Happiness 0.4 0.4 1.5 -0.6 -0.1 0.6 -0.6 -0.1 0.7 -1.2 -0.6
Noisy workplace 3.4 4.2 5.9 -2.3 -2.4 1.3 -2.3 -2.2 1.4 2.0 -2.0
Qualifications: A levels/AS levels or equivalent 2.3 5.0 16.6 0.8 2.0 -2.2 0.6 3.6 -4.1 0.7 0.8
Serious illness, injury or assault of a close relative in last 2 years 2.0 2.2 8.7 -1.5 -0.7 1.5 -1.3 -0.1 -2.9 0.8 -1.5
Mouth/teeth dental problems: Dentures 2.6 4.4 7.7 -1.7 -2.1 2.6 -1.7 -2.8 1.3 2.6 -1.4
Asthma 0.1 0.2 0.8 -0.5 -0.1 0.9 -0.2 -0.4 0.5 0.4 -0.6
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 2.7 -1.2 -1.3 1.6 -1.1 0.1 1.0 -0.4 -1.5
Medication: Cholesterol lowering 1.5 2.3 6.4 -1.8 -1.0 -1.2 -1.0 -1.7 2.5 -0.0 -1.7
Depression (self-reported) 0.4 0.4 0.8 -0.8 -0.3 0.1 -0.9 -0.5 0.8 0.4 -0.9
Medication: Lansoprazole 0.3 0.3 0.7 -0.6 -0.1 0.8 -0.7 -0.6 0.1 0.5 -0.8
Prospective memory result 0.1 0.1 0.7 -0.1 0.1 -0.2 0.1 0.9 0.2 -0.4 0.1
Lung cancer (father) 2.9 3.3 6.7 -2.0 -1.7 0.3 -2.2 -1.7 0.7 2.6 -2.2
Illnesses of mother 1.3 1.6 2.4 1.5 1.3 0.7 1.1 1.0 -1.5 -1.4 1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 2.2 -0.3 -0.4 1.5 -0.2 0.3 -1.1 -0.0 -0.6
Pulse wave Arterial Stiffness index 2.1 2.5 6.5 -0.6 -1.1 2.5 -0.9 -2.1 -0.2 2.3 -1.1
Impedance of arm (left) 0.8 3.7 24.8 0.5 0.4 1.1 -0.1 1.7 -5.0 -0.4 0.7
Arm fat mass (right) 2.1 8.6 13.5 -3.1 -2.5 2.8 -3.0 -3.1 1.4 3.7 -3.4
Trunk predicted mass 0.8 4.4 15.2 -1.9 -1.8 3.9 -2.3 -0.3 0.7 -1.5 -2.3
Standing height 1.3 12.6 53.0 -1.1 -1.3 7.3 -2.8 1.6 -4.5 -3.5 -1.4
Length of working week for main job 0.2 0.3 1.0 0.3 0.3 -0.2 0.4 -0.2 0.7 1.0 -0.1
Exposure to tobacco smoke at home 0.1 0.1 0.7 -0.1 -0.1 -0.2 0.2 0.2 0.4 -0.9 -0.0
Breastfed as a baby 0.3 0.4 1.7 -0.3 -0.3 0.8 -0.3 -0.3 -1.3 0.3 -0.3
Tense / ‘highly strung’ 1.1 1.9 4.0 -0.7 -0.7 1.5 -0.5 -1.8 2.0 1.9 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.8 6.2 -1.5 -0.9 1.8 -1.7 -1.7 1.5 2.5 -1.3
Hair/balding pattern: Pattern 4 0.3 0.7 2.5 -0.4 -0.5 -1.6 -0.4 -0.2 1.3 -0.9 -0.5
Birth weight of first child 0.5 1.0 1.7 -0.5 -1.1 1.1 -1.3 -1.3 -0.1 0.8 -1.1
Peak expiratory flow (PEF) 0.2 0.5 1.5 -0.8 -0.7 -0.0 -0.4 0.2 1.2 -0.0 -1.0
Pulse wave reflection index 0.1 0.1 0.3 0.2 0.3 -0.2 0.2 0.2 0.6 -0.5 -0.2
Ever highly irritable/argumentative for 2 days 1.0 1.2 4.8 -1.4 -0.5 0.2 -1.1 0.4 2.2 0.3 -1.1
Loud music exposure frequency 1.0 1.1 4.2 -0.7 -1.0 -0.4 -0.9 1.3 -2.0 0.1 -0.9
Qualifications: O levels/GCSEs or equivalent 3.2 5.1 11.9 1.9 2.0 -2.5 1.6 3.0 -3.5 -0.6 1.8
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 2.1 -0.9 -1.0 0.3 -0.8 1.1 -0.5 1.4 -1.0
Blood clot in the leg (DVT) 0.2 0.3 1.8 0.2 -0.6 -0.3 0.1 0.3 -0.3 1.3 -0.1
Medication: Paracetamol 2.7 4.4 8.8 -1.8 -1.8 2.5 -1.7 -2.7 -0.5 3.0 -1.9
Headache pain in last month 2.5 4.3 5.8 -2.1 -2.3 2.2 -2.1 -1.6 1.7 2.1 -2.4
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 6.8 1.2 1.2 1.5 0.3 1.0 -2.6 0.4 1.0
Glaucoma (self-reported) 0.4 0.4 1.4 -0.2 -0.3 1.2 0.1 -1.0 -0.7 0.4 -0.3
Gout (self-reported) 1.2 1.6 4.0 -1.4 -1.6 2.0 -1.2 -0.8 -0.7 -0.3 -1.1
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 1.9 0.6 0.5 -0.7 1.0 0.8 0.9 -1.4 0.3
Medication: Amlodipine 0.8 1.1 5.3 -0.8 -0.5 -2.3 -0.3 0.4 1.4 0.8 -0.4
Medication: Ventolin 100micrograms inhaler 1.1 1.4 2.7 1.3 1.7 -0.3 1.6 -0.0 1.1 -0.6 1.5
Birth weight 2.3 5.1 18.1 -1.7 -2.3 4.3 -2.4 -1.8 -0.8 0.7 -2.1
Chronic bronchitis/emphysema (mother) 0.6 0.7 3.5 -0.4 -0.8 -0.5 -0.4 -0.7 1.9 0.5 -0.5
High blood pressure (siblings) 2.5 3.6 6.8 2.4 1.4 -2.2 2.2 1.3 1.3 -1.0 2.6
Forced vital capacity (FVC), Best measure 0.5 1.8 8.4 -0.7 -0.6 2.9 -0.8 0.1 -1.7 -0.8 -1.0
Body fat percentage 2.4 9.6 17.8 -3.2 -2.7 3.0 -3.0 -3.6 0.5 4.2 -3.2
Leg fat percentage (right) 1.8 6.7 13.2 -2.6 -2.4 1.5 -2.1 -3.4 1.7 3.6 -2.5
Arm fat-free mass (right) 1.0 5.3 17.0 -2.3 -1.9 4.1 -2.5 -1.1 1.1 -0.9 -2.6
Exposure to tobacco smoke outside home 1.0 1.3 2.8 1.4 1.6 -0.2 1.7 0.2 -1.4 -0.1 1.1
Comparative body size at age 10 1.3 3.5 7.4 -2.5 -1.4 2.0 -2.1 -1.8 -0.2 0.9 -2.7
Number of full brothers 0.8 0.9 3.1 -0.5 -1.1 1.8 -0.6 -0.7 1.0 0.7 -0.9
Worry too long after embarrassment 0.4 0.7 1.7 0.9 1.2 0.7 0.5 0.2 0.9 0.4 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 3.4 0.3 0.5 -1.6 -0.3 1.0 1.0 1.9 0.2
Wheeze or whistling in the chest in last year 0.5 0.9 3.2 -0.1 -0.1 1.8 -0.1 -1.4 -0.7 1.2 -0.2
Number of children fathered 0.4 0.4 2.1 0.3 0.4 -1.4 0.3 0.7 0.2 -0.6 0.4
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 3.5 -1.0 -1.2 -1.9 -1.5 1.5 0.1 0.6 -0.7
Age at first live birth 2.4 4.2 8.6 1.7 2.5 -2.5 1.1 2.9 -2.4 -1.4 1.1
Pulse wave peak to peak time 1.9 2.2 5.8 0.5 1.0 -2.0 0.7 2.2 -0.0 -2.4 1.1
Health satisfaction 0.4 0.5 1.1 -0.1 -0.6 0.8 0.0 -1.1 0.7 1.1 -0.2
Shortness of breath walking on level ground 0.1 0.1 0.4 -0.1 -0.3 0.6 -0.2 -0.5 0.3 0.6 -0.1
Qualifications: College or University degree 2.3 7.3 17.2 1.1 3.2 -3.6 0.9 4.1 -3.5 -1.7 1.0
Eye problems/disorders: None of the above 1.6 1.8 3.1 1.7 1.8 0.5 1.7 0.4 -1.0 -1.4 1.5
Mouth/teeth dental problems: Loose teeth 3.1 3.7 5.8 -1.9 -2.4 2.3 -1.8 -1.1 -2.1 1.6 -1.9
Emphysema/chronic bronchitis 5.2 5.9 10.4 -2.3 -3.1 1.7 -2.6 -3.2 1.2 2.2 -2.5
Medication for pain relief, constipation, heartburn 2.3 3.9 9.2 1.3 1.5 -3.0 0.8 3.0 -1.4 -1.9 1.7
Neck or shoulder pain in last month 8.8 12.5 24.9 -4.5 -5.0 0.9 -3.7 -2.6 2.4 3.2 -4.2
Medication: Blood pressure 0.4 0.7 2.5 -0.6 -0.6 -1.0 0.4 -0.5 1.6 0.8 -0.4
Angina (self-reported) 1.2 1.6 6.4 -0.1 -0.6 1.1 0.2 -2.2 2.5 0.0 0.1
Migraine (self-reported) 1.5 1.8 5.6 -1.4 -0.7 1.6 -0.9 -2.4 1.1 0.8 -1.3
Medication: Ibuprofen 1.4 1.6 3.3 -1.6 -1.4 0.6 -1.3 0.7 1.5 -0.6 -1.8
Medication: Allopurinol 0.6 0.8 1.8 -1.0 -1.2 0.7 -1.4 0.3 -0.9 0.1 -0.9
Medication: Omeprazole 0.6 0.8 2.3 -0.2 -0.6 0.3 0.3 -1.0 1.5 1.5 0.0
Medication: Seretide 50 evohaler 0.2 0.3 1.1 -0.5 -0.3 0.1 -0.4 0.1 1.0 -0.6 -0.6
Mean time to correctly identify matches 0.5 0.9 2.6 1.0 1.0 -1.6 0.8 0.6 -0.8 -0.1 0.9
Heart disease (mother) 0.3 0.4 0.9 -0.7 -0.5 -0.4 -0.0 -0.7 1.0 0.5 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.7 0.3 0.5 0.5 0.6 -0.2 -0.8 1.3 -0.0
Whole body fat mass 2.2 9.2 14.0 -3.2 -2.6 3.7 -3.2 -3.1 0.5 3.2 -3.4
Leg fat mass (right) 1.8 7.1 9.7 -2.8 -2.5 2.5 -2.6 -3.0 1.6 3.1 -2.9
Arm predicted mass (right) 1.0 5.2 16.9 -2.3 -2.0 4.1 -2.5 -1.1 1.2 -0.9 -2.5
Pulse rate, automated reading 0.2 0.8 3.1 0.1 -0.3 0.5 -0.3 -1.6 0.5 1.8 0.1
Alcohol intake frequency. 0.5 1.2 4.8 -0.2 -1.2 0.5 0.4 -1.2 2.2 1.2 0.0
Comparative height size at age 10 0.8 4.7 17.6 -1.1 -2.1 4.2 -2.5 -0.2 -1.6 -2.0 -1.2
Number of full sisters 2.0 2.4 6.4 -1.0 -1.4 2.1 -1.2 -2.5 -0.3 0.7 -1.7
Suffer from ‘nerves’ 1.0 1.5 3.8 1.1 1.5 -1.7 0.6 1.9 0.3 0.2 1.2
Overall health rating 0.7 1.4 7.1 -0.8 -1.3 0.6 -0.7 -0.7 -0.2 2.7 -0.9
Chest pain or discomfort 1.7 2.4 10.8 -0.2 -0.6 2.1 -0.7 -1.5 -0.1 3.3 -0.6
Had major operations 4.2 4.9 10.0 -2.1 -2.5 3.2 -2.5 -2.2 0.3 0.8 -2.5
Age at last live birth 0.6 0.9 3.2 -0.2 0.8 -1.1 -0.3 1.0 -1.8 1.0 -0.4
Family relationship satisfaction 0.4 0.5 2.6 0.3 0.1 0.5 0.2 -0.1 1.6 -1.1 0.2
Leg pain on walking 1.3 1.6 2.9 1.3 1.2 -1.6 1.0 1.7 -1.1 -0.6 1.3
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.4 5.4 -1.0 -1.1 0.0 -1.0 -0.6 2.3 -0.7 -1.1
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.0 -0.4 -1.3 -0.8 -0.2 -0.5 1.4 1.4 -0.3
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 3.8 0.4 0.2 -0.9 0.4 -0.4 2.0 -0.9 0.4
Medication: Aspirin 1.0 1.3 3.8 -0.3 0.0 1.9 0.3 -1.9 1.5 1.0 -0.2
Supplements: Vitamin C 0.9 1.1 2.7 0.9 0.7 -0.1 0.9 1.6 -1.6 -0.5 1.0
Knee pain experienced in last month 1.3 1.9 4.8 -1.6 -2.2 0.7 -1.4 -0.2 -1.4 1.2 -1.6
Hypertension (Self-reported) 0.7 1.9 5.0 -1.1 -1.5 -1.4 -0.3 -0.8 1.9 2.2 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 3.6 -0.8 -0.4 1.1 -0.6 -1.9 -0.0 1.2 -0.9
Illnesses of father: Heart disease 0.4 0.5 1.1 -0.8 -1.0 0.2 -0.8 -0.3 0.9 -0.8 -0.6
Illnesses of siblings: Diabetes 0.6 0.7 1.5 -1.0 -1.1 -0.6 -0.0 0.3 0.9 1.2 -0.7
Smoking status: Previous 0.5 0.8 1.9 -0.9 -0.5 0.8 -1.1 -0.8 0.4 1.0 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 5.7 1.0 0.8 2.4 0.6 1.2 -1.1 -2.0 0.9
Whole body fat-free mass 0.9 5.3 17.9 -2.3 -1.8 4.2 -2.7 -0.6 0.4 -0.8 -2.8
Leg fat-free mass (right) 1.1 5.8 19.2 -2.5 -1.6 4.4 -2.9 -0.8 -0.3 0.4 -3.0
Arm fat percentage (left) 2.0 8.2 18.2 -3.0 -2.3 2.4 -2.6 -3.3 0.8 4.3 -3.0
Average weekly red wine intake 1.8 2.6 9.4 1.1 1.9 0.3 0.6 1.7 -3.1 -1.6 0.8
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.5 0.4 0.7 0.6 0.4 0.1 0.4 -0.5 0.7
Mood swings 1.0 1.8 6.5 -1.3 -1.1 0.8 -0.7 -1.2 1.0 2.6 -1.2
Loneliness, isolation 0.6 0.8 2.2 -0.5 -0.2 1.3 -0.6 0.2 1.5 -1.2 -0.6
Long-standing illness, disability or infirmity 3.6 5.5 12.9 -2.1 -2.5 2.2 -2.1 -2.0 -1.4 3.6 -2.2
Ever had bowel cancer screening 2.8 3.3 7.4 -1.9 -1.1 2.7 -2.2 -1.9 -0.4 0.7 -2.2
Diabetes diagnosed by doctor 0.4 0.6 2.7 -0.2 0.4 1.0 -0.2 -0.9 0.2 1.6 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.8 2.6 1.3 1.6 -1.4 1.4 1.6 0.9 -0.9 1.5
Friendships satisfaction 0.9 1.1 2.3 -1.1 -1.0 1.0 -1.2 -0.1 -1.5 0.5 -1.3
Qualifications: nursing, teaching 1.8 2.7 7.7 1.2 1.6 -1.3 1.2 1.9 -2.8 1.4 1.3
Commuting to job workplace: Walk 0.2 0.2 0.6 -0.1 0.5 0.8 -0.5 -0.4 0.2 -0.8 -0.3
Eye problems/disorders: Cataract 1.7 1.9 4.5 -1.9 -1.8 0.1 -2.1 0.8 0.3 0.4 -1.7
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 2.1 -0.4 -0.2 -0.6 -0.6 1.4 -1.3 -0.1 -0.8
Medication for cholesterol 0.7 1.0 3.6 0.9 0.9 -0.7 0.2 0.8 -1.9 -1.1 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.2 0.3 -0.2 -0.2 0.1 0.2 -0.5 0.4 0.1
Back pain experienced in last month 1.2 1.8 5.1 -1.4 -2.3 0.2 -1.2 0.4 -0.6 1.7 -1.5
Mineral and other dietary supplements 0.8 1.0 3.7 0.6 0.6 -1.9 0.9 0.2 1.3 1.0 0.7
Breast cancer (self-reported) 2.9 3.5 8.1 2.9 2.0 0.3 2.3 0.1 1.2 -1.3 2.7
Asthma (self-reported) 0.0 0.1 0.3 -0.3 -0.0 0.5 0.1 -0.1 0.2 0.4 -0.3
Osteoporosis (self-reported) 0.2 0.2 0.7 0.4 0.7 0.8 -0.1 0.0 -0.5 0.1 0.3
Osteoarthritis (self-reported) 2.1 2.7 4.0 -1.8 -1.9 1.1 -1.7 -2.0 1.3 1.5 -1.7
Medication: Aspirin 1.0 1.3 3.5 -0.3 -0.1 1.5 0.3 -1.9 1.8 1.1 -0.2
Medication: Gliclazide 0.4 0.4 2.0 0.5 0.8 1.4 0.5 -0.2 0.2 -0.4 0.4
Illnesses of father: None of the above (group 1) 0.9 1.1 5.3 -0.2 0.1 -0.2 -0.3 -0.4 -1.8 2.3 -0.6
Smoking status: Current 0.1 0.2 0.8 0.0 -0.0 0.7 0.4 -0.9 -0.6 -0.2 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 1.3 0.2 -0.0 -1.1 0.7 0.9 -0.3 0.0 0.0
Whole body water mass 0.9 5.1 17.1 -2.2 -1.8 4.1 -2.6 -0.5 0.5 -0.9 -2.7
Leg predicted mass (right) 1.1 5.8 18.7 -2.5 -1.6 4.3 -2.9 -0.7 -0.3 0.4 -3.0
Arm fat mass (left) 2.3 9.5 12.5 -3.3 -2.6 3.3 -3.2 -3.2 1.4 3.5 -3.5
Number of self-reported non-cancer illnesses 3.2 5.6 14.7 -1.7 -1.6 2.4 -1.4 -3.8 3.0 2.3 -1.7
Average weekly champagne plus white wine intake 0.4 0.6 1.0 0.8 1.0 0.7 0.7 0.1 1.0 -0.6 0.8
Miserableness 3.6 6.3 10.7 -2.5 -2.1 2.7 -2.0 -2.6 3.3 2.4 -2.4
Guilty feelings 0.5 0.7 3.0 0.0 0.4 0.9 0.5 -1.3 1.7 -0.1 0.3
Wears glasses or contact lenses 0.4 0.5 1.2 -0.6 -0.3 0.3 -0.8 -1.1 0.5 0.1 -1.1
Ever taken oral contraceptive pill 0.2 0.3 1.4 0.1 0.5 -0.3 0.0 1.2 -0.0 0.6 -0.0
Hearing aid user 0.7 0.8 2.0 -0.8 -1.4 0.2 -1.2 -0.1 -0.0 1.4 -0.6
Mother’s age at death 0.7 0.9 2.4 -1.1 -0.8 -0.6 -1.5 0.6 -0.9 0.3 -1.3
Financial situation satisfaction 0.7 0.9 2.5 -0.2 -0.4 1.6 -0.2 -1.2 1.6 -0.5 -0.2
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.3 -1.0 -1.1 -0.0 -0.8 -1.1 1.1 0.7 -0.6
Commuting to job workplace: Public transport 0.8 1.0 2.3 0.3 0.8 0.3 -0.4 1.5 -1.4 -1.4 0.4
Eye problems/disorders: Glaucoma 0.3 0.3 0.7 0.5 0.1 0.7 0.8 -0.7 -0.1 -0.3 0.7
Medication: Blood pressure 0.6 1.2 3.9 -0.7 -0.5 0.2 -0.1 -1.6 2.0 1.5 -0.3
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.8 0.5 0.0 -0.4 0.4 -0.3 -0.4 0.9 0.7
Supplements: Fish oil (including cod liver oil) 2.2 2.9 11.3 -1.4 -1.2 3.4 -1.4 -2.0 -0.5 -0.2 -1.4
High cholesterol (Self-reported) 1.1 2.0 10.4 -1.1 -0.7 -1.1 -0.3 -1.3 3.2 0.0 -0.9
Medication: Bendroflumethiazide 0.3 0.5 2.4 -0.2 0.3 -0.6 0.5 -0.9 1.5 0.5 -0.1
Medication: Paracetamol 1.9 3.0 4.5 -1.9 -1.8 1.5 -1.8 -1.4 -0.7 2.1 -2.0
Medication: Lisinopril 1.7 2.2 4.9 2.2 1.8 -0.4 2.0 0.5 1.0 0.5 2.0
Medication: Atorvastatin 1.1 1.4 4.9 -1.0 -1.5 -0.8 -0.6 -0.7 0.3 2.2 -1.1
Illnesses of father: High blood pressure 0.2 0.2 0.7 -0.3 -0.3 0.9 -0.1 -0.5 0.6 -0.3 -0.2
Alcohol drinker status: Never 0.4 0.5 1.1 1.0 1.1 0.2 0.8 0.6 -0.3 0.3 0.7
Ever smoked 0.9 1.5 2.6 -1.1 -0.9 1.4 -1.2 -1.2 -1.0 1.2 -1.6
Basal metabolic rate 1.1 6.1 19.0 -2.6 -2.0 4.4 -2.9 -1.0 0.6 -0.2 -3.0
Leg fat percentage (left) 2.3 8.4 18.5 -3.0 -2.7 1.6 -2.6 -3.6 1.4 4.3 -2.9
Arm fat-free mass (left) 1.0 5.3 14.0 -2.4 -2.0 3.7 -2.6 -1.0 1.6 -0.5 -2.8
Number of operations (self-reported) 1.3 1.9 3.8 -0.9 -1.7 2.0 -1.1 -1.3 1.0 1.5 -1.1
Average weekly beer plus cider intake 0.7 1.0 2.1 0.7 1.1 0.3 0.7 1.2 -1.2 1.4 0.7
Irritability 1.4 2.4 7.6 -0.6 -0.6 1.6 -0.4 -2.1 2.8 1.8 -0.7
Risk taking 0.3 0.4 1.0 0.7 1.0 0.4 0.7 0.0 -1.0 -0.6 0.6
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.3 0.1 -0.3 -0.2 0.0 -0.3 -0.3 -0.5 0.0
Fractured/broken bones in last 5 years 1.3 1.6 7.3 0.3 0.5 0.7 0.5 -1.4 2.7 -1.6 0.3
Age started oral contraceptive pill 0.7 0.9 2.2 -1.1 -0.6 -0.1 -1.5 -0.2 0.9 -1.4 -0.9
Diastolic blood pressure, automated reading 1.6 4.9 10.7 1.9 1.7 -3.3 1.9 2.7 -1.6 2.2 2.0
Ever depressed for a whole week 0.3 0.4 1.5 0.3 0.2 0.3 0.4 -0.3 1.2 -0.6 0.8
Unable to work because of sickness or disability 0.9 1.1 5.8 -0.4 -0.5 0.3 -0.4 -1.3 0.7 2.4 -0.5
Commuting to job workplace: Cycle 1.5 1.8 4.5 0.8 1.7 -1.1 0.4 2.1 -1.7 -1.2 0.7
Myopia 2.0 2.9 9.4 1.4 1.1 -1.5 1.4 1.4 -3.1 -1.5 1.4
Vascular/heart problems diagnosed by doctor 1.1 3.1 7.8 1.4 2.0 0.4 0.6 1.9 -2.3 -2.8 1.1
Cholesterol lowering medication 0.9 1.3 5.6 -0.7 -0.6 0.6 -0.3 -1.0 2.4 1.6 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 2.7 -0.1 -0.5 0.4 0.6 -1.2 1.6 1.1 0.2
Pain experienced in last month 2.4 4.1 11.3 2.3 3.4 -1.2 2.1 1.0 -0.8 -2.2 2.0
Supplements: Calcium 0.5 0.6 1.6 0.6 1.3 0.7 0.3 0.4 -0.3 -1.2 0.7
Basal cell carcinoma (self-reported) 0.2 0.3 0.6 0.2 0.7 0.6 -0.0 -0.8 0.7 -0.2 0.5
Heart attack/myocardial infarction (self-reported) 1.1 1.4 6.3 0.3 0.2 0.1 1.0 -0.6 2.5 -1.6 0.8
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 2.1 -0.3 -1.0 -0.2 -0.4 0.1 -0.5 1.5 -0.6
Heart disease (siblings) 0.5 0.6 1.1 0.8 0.2 0.7 1.0 -1.0 0.5 0.0 1.0
Alcohol drinker status: Previous 1.7 1.9 5.0 -1.2 -1.4 1.5 -1.0 -1.5 -0.1 2.2 -1.1
Pack years of smoking 0.8 1.1 4.1 0.0 -0.5 0.1 0.3 -2.0 1.9 1.0 0.0
Impedance of whole body 0.6 2.9 16.3 1.1 0.6 0.6 0.6 1.5 -4.0 -0.7 1.5
Leg fat mass (left) 2.2 8.4 11.7 -3.1 -2.7 2.7 -3.0 -3.2 1.4 3.4 -3.2
Arm predicted mass (left) 1.1 5.7 14.0 -2.6 -2.2 3.7 -2.8 -1.0 1.5 -0.6 -2.9