Best TWAS P=2.05e-13 · Best GWAS P=4.76e-13 conditioned to 0.95
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DENND2A | 0.09 | 0.04 | enet | 16 | 0.08 | 7.1e-10 | 5.1 | -5.2 | 1.6e-07 | -0.05 | 0.97 | 0.03 | FALSE |
2 | GTEx | Artery Aorta | PARP12 | 0.10 | 0.04 | lasso | 4 | 0.03 | 5.7e-03 | -6.3 | -6.7 | 1.6e-11 | -0.01 | 0.10 | 0.78 | TRUE |
3 | GTEx | Cells Transformed fibroblasts | NDUFB2 | 0.06 | 0.02 | lasso | 3 | 0.03 | 1.4e-03 | 4.7 | -5.9 | 2.9e-09 | -0.02 | 0.35 | 0.04 | FALSE |
4 | ROSMAP | Brain Pre-frontal Cortex | DENND2A | 0.06 | 0.02 | lasso | 5 | 0.02 | 1.5e-03 | 4.5 | -5.7 | 1.1e-08 | -0.10 | 0.62 | 0.21 | FALSE |
5 | YFS | Blood | BRAF | 0.01 | 0.02 | enet | 2 | 0.01 | 1.6e-04 | 6.4 | 6.2 | 5.8e-10 | 0.01 | 0.00 | 1.00 | TRUE |
6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NDUFB2 | 0.07 | 0.03 | blup | 26 | 0.04 | 6.6e-05 | 5.0 | -5.3 | 1.3e-07 | 0.03 | 0.00 | 0.96 | FALSE |
7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PARP12 | 0.05 | 0.00 | enet | 12 | 0.02 | 5.6e-03 | 5.4 | -6.9 | 6.3e-12 | -0.38 | 0.01 | 0.38 | FALSE |
8 | The Cancer Genome Atlas | Lung Adenocarcinoma | PARP12 | 0.02 | 0.01 | blup | 68 | 0.01 | 2.4e-02 | 6.9 | -7.3 | 2.1e-13 | -0.88 | 0.01 | 0.88 | TRUE |
9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PARP12 | 0.06 | 0.04 | lasso | 2 | 0.04 | 1.3e-04 | 6.8 | 6.2 | 5.7e-10 | 0.93 | 0.01 | 0.96 | FALSE |
10 | The Cancer Genome Atlas | Soft Tissue Sarcoma | LOC100134229 | 0.07 | 0.02 | blup | 33 | 0.03 | 1.1e-02 | -6.5 | 6.2 | 4.9e-10 | 0.05 | 0.02 | 0.47 | FALSE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | DENND2A | 0.03 | 0.01 | blup | 71 | 0.01 | 1.3e-02 | 5.4 | 5.7 | 9.8e-09 | 0.12 | 0.02 | 0.86 | TRUE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | PARP12 | 0.14 | 0.11 | enet | 10 | 0.12 | 9.4e-12 | 7.2 | -6.7 | 3.0e-11 | -0.93 | 0.00 | 1.00 | FALSE |