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chr7:148,262,532-151,756,038

Best TWAS P=1.89e-14 · Best GWAS P=3.41e-58 conditioned to 6.32e-60

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	METSIM	Adipose	AOC1	0.17	0.08	enet	26	0.11	3.2e-16	5.68	7.7	1.9e-14	-0.02	0.52	0.48	TRUE
4	GTEx	Artery Coronary	RP11-148K1.12	0.31	-0.01	enet	16	0.00	2.2e-01	6.04	-7.2	8.8e-13	-0.02	0.02	0.78	TRUE
6	GTEx	Brain Cerebellum	KCNH2	0.35	0.20	enet	24	0.28	4.8e-09	-8.83	-6.9	5.6e-12	-0.01	0.87	0.06	TRUE
12	GTEx	Skin Sun Exposed Lower leg	NUB1	0.20	0.12	enet	26	0.13	5.9e-11	-3.88	6.5	1.0e-10	-0.04	1.00	0.00	TRUE
8	GTEx	Colon Sigmoid	RP4-800G7.2	0.17	0.06	lasso	4	0.06	3.9e-03	3.44	5.9	4.5e-09	0.06	0.32	0.05	TRUE
7	GTEx	Cells Transformed fibroblasts	CHPF2	0.12	0.03	enet	10	0.00	1.8e-01	-4.72	5.6	2.7e-08	0.01	0.28	0.04	TRUE
32	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TMEM176A	0.15	0.00	lasso	10	0.02	5.7e-02	8.74	7.6	3.7e-14	0.02	0.01	0.31	FALSE
27	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ABP1	0.26	0.20	enet	10	0.17	1.4e-08	-6.53	-7.0	1.9e-12	0.03	0.97	0.03	FALSE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM176A	0.19	0.05	lasso	6	0.13	2.6e-14	-7.00	7.0	2.0e-12	-0.04	0.06	0.94	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TMEM176A	0.07	0.04	lasso	8	0.03	7.0e-05	6.40	6.8	9.6e-12	0.06	0.64	0.08	FALSE
19	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TMEM176A	0.06	0.01	blup	60	0.03	1.0e-03	5.92	6.8	1.0e-11	0.01	0.06	0.17	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ABP1	0.16	0.19	lasso	4	0.20	9.3e-22	-7.00	6.8	1.3e-11	-0.02	1.00	0.00	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	TMEM176A	0.25	0.17	enet	19	0.20	1.5e-25	4.71	6.7	2.1e-11	0.04	1.00	0.00	FALSE
18	YFS	Blood	FASTK	0.04	0.01	blup	515	0.02	1.9e-07	3.51	6.7	2.1e-11	0.01	1.00	0.00	FALSE
14	GTEx	Uterus	GIMAP4	0.32	-0.01	enet	42	0.02	1.4e-01	2.40	-6.4	1.3e-10	0.02	0.06	0.06	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM176A	0.04	0.01	blup	60	0.04	4.0e-08	5.92	5.8	6.5e-09	0.04	0.12	0.16	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM176A	0.32	0.09	blup	60	0.11	6.7e-11	-0.05	5.7	1.3e-08	0.00	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ATG9B	0.08	0.03	lasso	3	0.03	2.5e-03	-0.58	-5.6	1.7e-08	0.06	0.01	0.86	FALSE
31	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM176A	0.15	0.01	blup	60	0.04	6.1e-05	8.74	5.5	2.9e-08	0.02	0.06	0.69	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHPF2	0.06	0.02	lasso	5	0.02	1.3e-03	-5.30	5.5	3.4e-08	0.00	0.01	0.97	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CHPF2	0.07	0.03	blup	51	0.05	8.6e-07	4.20	5.5	4.6e-08	0.01	0.08	0.86	FALSE
3	GTEx	Artery Aorta	NUB1	0.30	0.23	lasso	4	0.23	7.9e-13	-4.30	5.4	5.4e-08	-0.07	1.00	0.00	FALSE
5	GTEx	Brain Cerebellar Hemisphere	KCNH2	0.34	0.09	lasso	5	0.12	5.0e-04	4.36	-5.4	5.9e-08	0.01	0.12	0.07	FALSE
26	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM176A	0.17	0.05	blup	60	0.07	5.1e-05	-1.79	5.4	7.1e-08	-0.04	0.36	0.26	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM176B	0.21	0.11	blup	72	0.15	2.4e-16	1.32	5.4	7.3e-08	0.00	1.00	0.00	FALSE
11	GTEx	Lung	CHPF2	0.11	0.00	lasso	1	0.00	2.0e-01	-5.30	5.3	1.1e-07	0.01	0.36	0.02	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	TMUB1	0.05	0.01	bslmm	511	0.01	7.2e-03	4.26	-5.3	1.1e-07	-0.02	0.09	0.04	FALSE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM176A	0.22	0.01	blup	60	0.14	1.7e-15	1.32	5.2	1.5e-07	-0.03	0.92	0.03	FALSE
2	GTEx	Adipose Subcutaneous	NUB1	0.17	0.09	lasso	4	0.12	8.9e-10	5.03	5.2	1.6e-07	-0.06	0.99	0.00	FALSE
9	GTEx	Heart Atrial Appendage	TMEM176B	0.37	0.06	enet	15	0.23	1.1e-10	-0.05	-5.2	1.6e-07	0.05	0.58	0.05	FALSE
28	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM176B	0.06	0.01	blup	72	0.03	7.7e-05	1.31	5.2	1.9e-07	0.03	0.08	0.16	FALSE
10	GTEx	Heart Left Ventricle	FASTK	0.26	0.04	enet	8	0.04	3.0e-03	3.51	5.2	2.0e-07	0.04	0.12	0.04	FALSE
35	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ZNF786	0.20	0.06	blup	29	0.09	1.4e-03	3.35	-5.2	2.2e-07	0.02	0.05	0.08	FALSE
13	GTEx	Spleen	ZNF783	0.32	-0.01	enet	34	0.05	2.4e-02	3.35	5.2	2.5e-07	0.13	0.09	0.05	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	CHPF2	0.03	0.03	blup	51	0.03	1.2e-03	-4.67	5.1	2.9e-07	0.01	0.02	0.87	FALSE