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chr8:119,737,284-122,078,334

Best TWAS P=9.58e-25 · Best GWAS P=2.8e-27 conditioned to 6.59e-211

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
21	GTEx	Lung	NOV	0.06	0.02	enet	23	0.03	2.5e-03	-6.8	-10.3	9.6e-25	0.67	0.28	0.24	TRUE
28	NTR	Blood	NOV	0.02	0.01	bslmm	481	0.01	1.7e-04	-10.5	-9.5	2.7e-21	0.68	0.09	0.89	TRUE
4	GTEx	Adrenal Gland	DEPTOR	0.16	-0.01	enet	24	0.00	3.7e-01	-5.0	8.5	1.9e-17	-0.09	0.10	0.05	TRUE
23	GTEx	Nerve Tibial	TAF2	0.14	0.04	enet	10	0.07	1.5e-05	5.8	-8.0	1.1e-15	0.25	0.83	0.10	TRUE
16	GTEx	Esophagus Gastroesophageal Junction	TAF2	0.14	0.00	enet	12	-0.01	5.6e-01	6.2	-7.4	1.2e-13	0.12	0.11	0.05	TRUE
19	GTEx	Liver	RP11-760H22.2	0.14	0.08	lasso	2	0.10	1.3e-03	4.9	-6.3	3.8e-10	0.02	0.32	0.05	TRUE
27	GTEx	Whole Blood	TAF2	0.05	0.03	enet	11	0.05	4.9e-05	5.4	-5.2	2.5e-07	0.00	0.63	0.01	TRUE
8	GTEx	Brain Cerebellum	DSCC1	0.71	0.47	lasso	15	0.49	1.7e-16	4.2	-5.1	2.8e-07	0.13	1.00	0.00	TRUE
13	GTEx	Colon Sigmoid	NOV	0.15	0.16	lasso	4	0.15	6.6e-06	-10.2	-10.2	2.4e-24	0.87	0.07	0.91	FALSE
5	GTEx	Artery Aorta	NOV	0.12	0.05	enet	18	0.04	3.7e-03	-7.8	-9.9	5.4e-23	0.68	0.10	0.57	FALSE
31	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NOV	0.03	0.00	blup	42	0.01	5.3e-02	-9.7	-9.9	6.1e-23	0.85	0.05	0.40	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	NOV	0.04	0.05	blup	42	0.05	8.7e-06	-10.5	-9.4	7.7e-21	0.85	0.01	0.99	FALSE
12	GTEx	Cells Transformed fibroblasts	NOV	0.10	0.04	enet	30	0.03	3.7e-03	-10.8	-9.3	1.5e-20	0.77	0.00	0.99	FALSE
34	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NOV	0.11	0.02	enet	15	0.05	2.9e-03	-10.2	-9.1	5.8e-20	0.74	0.02	0.35	FALSE
25	GTEx	Skin Sun Exposed Lower leg	NOV	0.11	0.03	lasso	7	0.04	1.4e-04	-9.7	-9.0	2.3e-19	0.83	0.07	0.92	FALSE
32	The Cancer Genome Atlas	Colon Adenocarcinoma	NOV	0.31	0.10	blup	42	0.10	1.2e-06	-10.2	-8.4	3.4e-17	0.69	0.12	0.81	FALSE
9	GTEx	Brain Cerebellum	DEPTOR	0.24	0.22	lasso	3	0.17	7.9e-06	8.0	-8.1	8.0e-16	0.08	0.42	0.05	FALSE
1	CommonMind	Brain Pre-frontal Cortex	NOV	0.06	0.02	enet	8	0.05	1.5e-06	-5.7	-8.0	1.4e-15	0.76	0.02	0.98	FALSE
7	GTEx	Brain Cerebellar Hemisphere	DEPTOR	0.32	0.15	lasso	8	0.29	3.4e-08	8.0	-8.0	1.6e-15	0.12	0.61	0.02	FALSE
18	GTEx	Esophagus Muscularis	NOV	0.11	0.03	enet	19	0.05	3.9e-04	-10.2	-7.3	2.4e-13	0.71	0.04	0.92	FALSE
22	GTEx	Lung	DEPTOR	0.16	0.12	enet	28	0.15	1.3e-11	8.0	7.3	2.5e-13	-0.12	1.00	0.00	FALSE
26	GTEx	Thyroid	COL14A1	0.10	0.02	enet	14	0.02	2.3e-02	6.3	-7.2	5.3e-13	0.18	0.19	0.05	FALSE
14	GTEx	Colon Sigmoid	DEPTOR	0.28	0.22	lasso	4	0.23	1.7e-08	7.0	7.2	8.1e-13	-0.08	0.92	0.00	FALSE
37	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DEPDC6	0.19	0.04	blup	142	0.11	1.1e-04	4.9	-6.8	1.1e-11	0.17	0.03	0.95	FALSE
6	GTEx	Artery Tibial	NOV	0.09	0.00	enet	33	0.00	2.7e-01	-10.2	-6.8	1.3e-11	0.50	0.04	0.89	FALSE
3	GTEx	Adipose Subcutaneous	TAF2	0.11	0.07	lasso	6	0.10	1.7e-08	5.4	-6.6	5.1e-11	-0.02	0.94	0.00	FALSE
35	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	DSCC1	0.10	0.04	blup	54	0.06	2.2e-03	5.0	-6.4	1.3e-10	0.14	0.03	0.64	FALSE
20	GTEx	Lung	TAF2	0.14	0.09	lasso	4	0.07	5.5e-06	5.8	-6.3	2.3e-10	0.04	0.88	0.01	FALSE
11	GTEx	Breast Mammary Tissue	TAF2	0.09	0.11	lasso	3	0.07	1.2e-04	6.2	-6.3	2.7e-10	0.02	0.50	0.02	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	NOV	0.10	0.02	bslmm	475	0.07	5.7e-09	-9.7	6.1	1.4e-09	-0.61	0.25	0.74	FALSE
24	GTEx	Prostate	DSCC1	0.52	0.46	lasso	5	0.48	6.2e-14	4.2	-6.0	1.8e-09	0.18	0.97	0.00	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NOV	0.06	0.00	blup	42	0.03	4.3e-04	-10.5	-5.8	6.1e-09	0.52	0.02	0.38	FALSE
15	GTEx	Colon Sigmoid	RP11-760H22.2	0.23	0.05	enet	39	0.09	4.1e-04	7.0	5.6	2.2e-08	-0.07	0.11	0.05	FALSE
17	GTEx	Esophagus Muscularis	TAF2	0.13	0.09	lasso	4	0.08	1.5e-05	5.4	-5.4	5.9e-08	0.04	0.63	0.02	FALSE
10	GTEx	Brain Cortex	DSCC1	0.31	0.27	lasso	3	0.28	2.8e-08	4.2	-5.3	9.8e-08	0.12	0.66	0.03	FALSE
30	YFS	Blood	TAF2	0.02	0.02	lasso	8	0.02	5.8e-06	5.4	-5.3	9.9e-08	0.04	0.99	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TAF2	0.16	0.10	lasso	14	0.15	9.2e-18	-3.5	-5.2	1.9e-07	-0.06	1.00	0.00	FALSE