Best TWAS P=9.58e-25 · Best GWAS P=2.8e-27 conditioned to 6.59e-211
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | NOV | 0.06 | 0.02 | enet | 8 | 0.05 | 1.5e-06 | -5.7 | -8.0 | 1.4e-15 | 0.76 | 0.02 | 0.98 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | TAF2 | 0.16 | 0.10 | lasso | 14 | 0.15 | 9.2e-18 | -3.5 | -5.2 | 1.9e-07 | -0.06 | 1.00 | 0.00 | FALSE |
3 | GTEx | Adipose Subcutaneous | TAF2 | 0.11 | 0.07 | lasso | 6 | 0.10 | 1.7e-08 | 5.4 | -6.6 | 5.1e-11 | -0.02 | 0.94 | 0.00 | FALSE |
4 | GTEx | Adrenal Gland | DEPTOR | 0.16 | -0.01 | enet | 24 | 0.00 | 3.7e-01 | -5.0 | 8.5 | 1.9e-17 | -0.09 | 0.10 | 0.05 | TRUE |
5 | GTEx | Artery Aorta | NOV | 0.12 | 0.05 | enet | 18 | 0.04 | 3.7e-03 | -7.8 | -9.9 | 5.4e-23 | 0.68 | 0.10 | 0.57 | FALSE |
6 | GTEx | Artery Tibial | NOV | 0.09 | 0.00 | enet | 33 | 0.00 | 2.7e-01 | -10.2 | -6.8 | 1.3e-11 | 0.50 | 0.04 | 0.89 | FALSE |
7 | GTEx | Brain Cerebellar Hemisphere | DEPTOR | 0.32 | 0.15 | lasso | 8 | 0.29 | 3.4e-08 | 8.0 | -8.0 | 1.6e-15 | 0.12 | 0.61 | 0.02 | FALSE |
8 | GTEx | Brain Cerebellum | DSCC1 | 0.71 | 0.47 | lasso | 15 | 0.49 | 1.7e-16 | 4.2 | -5.1 | 2.8e-07 | 0.13 | 1.00 | 0.00 | TRUE |
9 | GTEx | Brain Cerebellum | DEPTOR | 0.24 | 0.22 | lasso | 3 | 0.17 | 7.9e-06 | 8.0 | -8.1 | 8.0e-16 | 0.08 | 0.42 | 0.05 | FALSE |
10 | GTEx | Brain Cortex | DSCC1 | 0.31 | 0.27 | lasso | 3 | 0.28 | 2.8e-08 | 4.2 | -5.3 | 9.8e-08 | 0.12 | 0.66 | 0.03 | FALSE |
11 | GTEx | Breast Mammary Tissue | TAF2 | 0.09 | 0.11 | lasso | 3 | 0.07 | 1.2e-04 | 6.2 | -6.3 | 2.7e-10 | 0.02 | 0.50 | 0.02 | FALSE |
12 | GTEx | Cells Transformed fibroblasts | NOV | 0.10 | 0.04 | enet | 30 | 0.03 | 3.7e-03 | -10.8 | -9.3 | 1.5e-20 | 0.77 | 0.00 | 0.99 | FALSE |
13 | GTEx | Colon Sigmoid | NOV | 0.15 | 0.16 | lasso | 4 | 0.15 | 6.6e-06 | -10.2 | -10.2 | 2.4e-24 | 0.87 | 0.07 | 0.91 | FALSE |
14 | GTEx | Colon Sigmoid | DEPTOR | 0.28 | 0.22 | lasso | 4 | 0.23 | 1.7e-08 | 7.0 | 7.2 | 8.1e-13 | -0.08 | 0.92 | 0.00 | FALSE |
15 | GTEx | Colon Sigmoid | RP11-760H22.2 | 0.23 | 0.05 | enet | 39 | 0.09 | 4.1e-04 | 7.0 | 5.6 | 2.2e-08 | -0.07 | 0.11 | 0.05 | FALSE |
16 | GTEx | Esophagus Gastroesophageal Junction | TAF2 | 0.14 | 0.00 | enet | 12 | -0.01 | 5.6e-01 | 6.2 | -7.4 | 1.2e-13 | 0.12 | 0.11 | 0.05 | TRUE |
17 | GTEx | Esophagus Muscularis | TAF2 | 0.13 | 0.09 | lasso | 4 | 0.08 | 1.5e-05 | 5.4 | -5.4 | 5.9e-08 | 0.04 | 0.63 | 0.02 | FALSE |
18 | GTEx | Esophagus Muscularis | NOV | 0.11 | 0.03 | enet | 19 | 0.05 | 3.9e-04 | -10.2 | -7.3 | 2.4e-13 | 0.71 | 0.04 | 0.92 | FALSE |
19 | GTEx | Liver | RP11-760H22.2 | 0.14 | 0.08 | lasso | 2 | 0.10 | 1.3e-03 | 4.9 | -6.3 | 3.8e-10 | 0.02 | 0.32 | 0.05 | TRUE |
20 | GTEx | Lung | TAF2 | 0.14 | 0.09 | lasso | 4 | 0.07 | 5.5e-06 | 5.8 | -6.3 | 2.3e-10 | 0.04 | 0.88 | 0.01 | FALSE |
21 | GTEx | Lung | NOV | 0.06 | 0.02 | enet | 23 | 0.03 | 2.5e-03 | -6.8 | -10.3 | 9.6e-25 | 0.67 | 0.28 | 0.24 | TRUE |
22 | GTEx | Lung | DEPTOR | 0.16 | 0.12 | enet | 28 | 0.15 | 1.3e-11 | 8.0 | 7.3 | 2.5e-13 | -0.12 | 1.00 | 0.00 | FALSE |
23 | GTEx | Nerve Tibial | TAF2 | 0.14 | 0.04 | enet | 10 | 0.07 | 1.5e-05 | 5.8 | -8.0 | 1.1e-15 | 0.25 | 0.83 | 0.10 | TRUE |
24 | GTEx | Prostate | DSCC1 | 0.52 | 0.46 | lasso | 5 | 0.48 | 6.2e-14 | 4.2 | -6.0 | 1.8e-09 | 0.18 | 0.97 | 0.00 | FALSE |
25 | GTEx | Skin Sun Exposed Lower leg | NOV | 0.11 | 0.03 | lasso | 7 | 0.04 | 1.4e-04 | -9.7 | -9.0 | 2.3e-19 | 0.83 | 0.07 | 0.92 | FALSE |
26 | GTEx | Thyroid | COL14A1 | 0.10 | 0.02 | enet | 14 | 0.02 | 2.3e-02 | 6.3 | -7.2 | 5.3e-13 | 0.18 | 0.19 | 0.05 | FALSE |
27 | GTEx | Whole Blood | TAF2 | 0.05 | 0.03 | enet | 11 | 0.05 | 4.9e-05 | 5.4 | -5.2 | 2.5e-07 | 0.00 | 0.63 | 0.01 | TRUE |
28 | NTR | Blood | NOV | 0.02 | 0.01 | bslmm | 481 | 0.01 | 1.7e-04 | -10.5 | -9.5 | 2.7e-21 | 0.68 | 0.09 | 0.89 | TRUE |
29 | ROSMAP | Brain Pre-frontal Cortex | NOV | 0.10 | 0.02 | bslmm | 475 | 0.07 | 5.7e-09 | -9.7 | 6.1 | 1.4e-09 | -0.61 | 0.25 | 0.74 | FALSE |
30 | YFS | Blood | TAF2 | 0.02 | 0.02 | lasso | 8 | 0.02 | 5.8e-06 | 5.4 | -5.3 | 9.9e-08 | 0.04 | 0.99 | 0.00 | FALSE |
31 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NOV | 0.03 | 0.00 | blup | 42 | 0.01 | 5.3e-02 | -9.7 | -9.9 | 6.1e-23 | 0.85 | 0.05 | 0.40 | FALSE |
32 | The Cancer Genome Atlas | Colon Adenocarcinoma | NOV | 0.31 | 0.10 | blup | 42 | 0.10 | 1.2e-06 | -10.2 | -8.4 | 3.4e-17 | 0.69 | 0.12 | 0.81 | FALSE |
33 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NOV | 0.06 | 0.00 | blup | 42 | 0.03 | 4.3e-04 | -10.5 | -5.8 | 6.1e-09 | 0.52 | 0.02 | 0.38 | FALSE |
34 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NOV | 0.11 | 0.02 | enet | 15 | 0.05 | 2.9e-03 | -10.2 | -9.1 | 5.8e-20 | 0.74 | 0.02 | 0.35 | FALSE |
35 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | DSCC1 | 0.10 | 0.04 | blup | 54 | 0.06 | 2.2e-03 | 5.0 | -6.4 | 1.3e-10 | 0.14 | 0.03 | 0.64 | FALSE |
36 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NOV | 0.04 | 0.05 | blup | 42 | 0.05 | 8.7e-06 | -10.5 | -9.4 | 7.7e-21 | 0.85 | 0.01 | 0.99 | FALSE |
37 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | DEPDC6 | 0.19 | 0.04 | blup | 142 | 0.11 | 1.1e-04 | 4.9 | -6.8 | 1.1e-11 | 0.17 | 0.03 | 0.95 | FALSE |