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chr12:27,172,878-30,229,606

Best TWAS P=1.97e-63 · Best GWAS P=3.43e-64 conditioned to 0.000183

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	GTEx	Cells Transformed fibroblasts	RP11-967K21.1	0.07	0.07	lasso	2	0.07	3.7e-06	-16.64	16.8	2.0e-63	-0.94	0.02	0.98	TRUE
51	GTEx	Small Intestine Terminal Ileum	RP11-996F15.2	0.60	0.51	lasso	5	0.46	7.1e-12	8.83	8.9	4.5e-19	0.02	0.00	1.00	TRUE
36	GTEx	Heart Atrial Appendage	RP11-967K21.1	0.08	0.09	lasso	1	0.08	2.3e-04	-16.64	16.6	3.8e-62	-0.97	0.02	0.96	FALSE
49	GTEx	Skin Sun Exposed Lower leg	CCDC91	0.09	0.01	enet	8	0.01	2.6e-02	-16.64	-16.6	5.8e-62	0.95	0.04	0.93	FALSE
70	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CCDC91	0.09	0.11	lasso	2	0.12	2.3e-05	-16.43	-16.4	9.4e-61	0.89	0.09	0.88	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	CCDC91	0.26	0.05	lasso	15	0.04	4.1e-03	-15.97	-16.0	1.1e-57	0.75	0.18	0.81	FALSE
64	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCDC91	0.04	0.04	lasso	3	0.03	1.8e-06	-15.93	-15.9	5.0e-57	0.87	0.75	0.25	FALSE
21	GTEx	Cells Transformed fibroblasts	CCDC91	0.10	0.10	lasso	5	0.09	5.5e-07	-15.12	-15.6	5.8e-55	0.72	0.85	0.13	FALSE
35	GTEx	Heart Atrial Appendage	CCDC91	0.10	0.06	lasso	8	0.04	4.4e-03	-15.12	-15.3	8.2e-53	0.77	0.07	0.84	FALSE
39	GTEx	Muscle Skeletal	RP11-967K21.1	0.04	0.01	lasso	9	0.00	2.9e-01	-15.30	15.0	9.6e-51	-0.77	0.25	0.21	FALSE
8	GTEx	Artery Aorta	RP11-967K21.1	0.07	0.02	lasso	7	0.01	7.9e-02	9.57	14.7	7.6e-49	-0.81	0.20	0.42	FALSE
25	GTEx	Colon Transverse	CCDC91	0.11	0.01	lasso	6	0.00	4.6e-01	-15.30	-14.7	1.2e-48	0.75	0.10	0.74	FALSE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCDC91	0.06	0.02	blup	174	0.04	2.9e-05	8.41	-14.6	4.7e-48	0.75	0.65	0.31	FALSE
69	The Cancer Genome Atlas	Lung Adenocarcinoma	CCDC91	0.09	0.01	blup	170	0.02	1.0e-03	-15.77	-14.1	2.7e-45	0.68	0.38	0.32	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CCDC91	0.08	0.06	lasso	6	0.07	9.4e-09	-15.91	13.9	4.4e-44	-0.81	0.96	0.03	FALSE
62	NTR	Blood	CCDC91	0.01	0.01	blup	648	0.00	9.0e-03	7.07	-12.5	9.0e-36	0.70	0.35	0.18	FALSE
72	The Cancer Genome Atlas	Thyroid Carcinoma	CCDC91	0.40	0.12	blup	175	0.14	4.9e-13	-15.62	-12.3	1.5e-34	0.55	1.00	0.00	FALSE
55	GTEx	Thyroid	CCDC91	0.15	0.12	enet	42	0.12	2.9e-09	-15.77	-11.9	1.1e-32	0.74	0.59	0.41	FALSE
44	GTEx	Pituitary	RP11-967K21.1	0.20	0.04	lasso	7	0.04	4.4e-02	7.86	11.6	3.9e-31	-0.61	0.06	0.52	FALSE
30	GTEx	Esophagus Mucosa	CCDC91	0.18	0.04	enet	36	0.03	3.1e-03	9.59	-11.6	6.6e-31	0.56	0.34	0.23	FALSE
7	GTEx	Artery Aorta	CCDC91	0.16	0.00	enet	37	0.02	4.1e-02	-15.77	-11.2	6.9e-29	0.50	0.08	0.79	FALSE
71	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC91	0.22	0.00	enet	16	0.04	2.5e-05	7.71	-9.5	3.2e-21	0.38	0.02	0.10	FALSE
4	GTEx	Adrenal Gland	CCDC91	0.16	0.01	lasso	16	0.03	3.5e-02	4.69	-9.3	1.6e-20	0.40	0.07	0.60	FALSE
26	GTEx	Colon Transverse	RP11-967K21.1	0.12	0.07	lasso	8	0.05	1.6e-03	7.25	9.2	3.9e-20	-0.52	0.36	0.47	FALSE
17	GTEx	Breast Mammary Tissue (Male)	RP11-996F15.2	0.52	0.28	lasso	9	0.23	4.1e-06	8.70	8.9	6.8e-19	0.03	0.00	0.98	FALSE
6	GTEx	Adrenal Gland	RP11-996F15.2	0.62	0.55	lasso	7	0.55	3.0e-23	8.70	8.9	7.8e-19	0.02	0.00	1.00	FALSE
16	GTEx	Breast Mammary Tissue	RP11-996F15.2	0.45	0.35	lasso	8	0.31	1.2e-16	8.83	8.9	7.9e-19	0.02	0.00	1.00	FALSE
13	GTEx	Artery Tibial	RP11-996F15.2	0.44	0.40	enet	28	0.44	1.2e-37	8.83	8.8	9.9e-19	0.03	0.00	1.00	FALSE
50	GTEx	Skin Sun Exposed Lower leg	RP11-996F15.2	0.50	0.48	enet	21	0.50	1.5e-47	8.83	8.8	1.6e-18	0.02	0.00	1.00	FALSE
57	GTEx	Thyroid	RP11-996F15.2	0.54	0.54	lasso	8	0.55	9.1e-50	8.83	8.8	1.6e-18	0.02	0.00	1.00	FALSE
43	GTEx	Pancreas	RP11-996F15.2	0.56	0.46	enet	22	0.48	1.8e-22	8.70	8.7	2.2e-18	0.01	0.00	1.00	FALSE
40	GTEx	Muscle Skeletal	RP11-996F15.2	0.24	0.26	lasso	11	0.25	9.3e-25	8.83	8.7	2.5e-18	0.02	0.00	1.00	FALSE
18	GTEx	Breast Mammary Tissue (Female)	RP11-996F15.2	0.42	0.38	lasso	1	0.35	3.5e-11	8.70	8.7	3.3e-18	0.02	0.00	1.00	FALSE
27	GTEx	Colon Transverse	RP11-996F15.2	0.31	0.32	lasso	1	0.31	3.5e-15	8.70	8.7	3.3e-18	0.02	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	RP11-996F15.2	0.46	0.38	lasso	10	0.38	4.1e-33	8.70	8.7	3.4e-18	0.02	0.00	1.00	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ERGIC2	0.04	0.03	lasso	2	0.03	1.3e-04	8.70	-8.7	4.2e-18	-0.01	0.01	0.99	FALSE
53	GTEx	Stomach	RP11-996F15.2	0.35	0.41	lasso	3	0.40	1.4e-20	8.70	8.7	4.6e-18	0.01	0.00	1.00	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	RP11-996F15.2	0.50	0.42	lasso	8	0.42	1.4e-16	8.70	8.7	5.2e-18	0.02	0.00	1.00	FALSE
31	GTEx	Esophagus Mucosa	RP11-996F15.2	0.39	0.43	lasso	7	0.45	6.2e-33	8.70	8.6	5.5e-18	0.03	0.00	1.00	FALSE
60	GTEx	Whole Blood	RP11-996F15.2	0.20	0.18	enet	11	0.18	9.2e-17	8.70	8.6	6.6e-18	0.04	0.00	1.00	FALSE
15	GTEx	Brain Cerebellum	RP11-996F15.2	0.25	0.15	lasso	4	0.10	7.6e-04	8.70	8.6	6.7e-18	0.02	0.01	0.94	FALSE
3	GTEx	Adipose Visceral Omentum	RP11-996F15.2	0.40	0.34	enet	12	0.33	7.9e-18	8.70	8.6	9.2e-18	0.01	0.00	1.00	FALSE
38	GTEx	Lung	RP11-996F15.2	0.50	0.46	lasso	5	0.46	1.9e-39	8.70	8.6	1.0e-17	0.02	0.00	1.00	FALSE
45	GTEx	Pituitary	RP11-996F15.2	0.54	0.42	lasso	8	0.32	7.7e-09	8.70	8.6	1.2e-17	0.03	0.00	1.00	FALSE
54	GTEx	Testis	RP11-996F15.2	0.28	0.35	lasso	2	0.37	2.7e-17	8.70	8.6	1.2e-17	0.00	0.00	1.00	FALSE
9	GTEx	Artery Aorta	RP11-996F15.2	0.35	0.28	lasso	4	0.28	1.5e-15	8.70	8.6	1.3e-17	0.02	0.00	1.00	FALSE
46	GTEx	Prostate	RP11-996F15.2	0.49	0.36	enet	32	0.39	6.0e-11	8.70	8.5	1.6e-17	0.02	0.00	1.00	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	RP11-996F15.2	0.27	0.24	lasso	4	0.23	6.0e-08	8.70	8.5	2.1e-17	0.02	0.00	1.00	FALSE
52	GTEx	Spleen	RP11-996F15.2	0.53	0.49	lasso	5	0.46	1.7e-13	8.83	8.5	2.1e-17	0.03	0.00	1.00	FALSE
23	GTEx	Cells Transformed fibroblasts	RP11-996F15.2	0.34	0.33	lasso	7	0.34	7.3e-26	8.70	8.5	2.4e-17	0.01	0.00	1.00	FALSE
32	GTEx	Esophagus Muscularis	RP11-967K21.1	0.07	0.06	lasso	5	0.04	2.2e-03	7.32	8.5	2.4e-17	-0.50	0.21	0.41	FALSE
12	GTEx	Artery Tibial	RP11-967K21.1	0.09	0.10	lasso	11	0.07	2.4e-06	7.22	8.5	2.7e-17	-0.53	0.81	0.19	FALSE
41	GTEx	Nerve Tibial	RP11-996F15.2	0.52	0.53	lasso	5	0.56	3.3e-47	8.70	8.4	3.6e-17	0.03	0.00	1.00	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	RP11-996F15.2	0.21	0.22	lasso	7	0.24	5.1e-30	8.70	8.4	3.9e-17	0.03	0.00	1.00	FALSE
24	GTEx	Colon Sigmoid	RP11-996F15.2	0.42	0.27	lasso	7	0.29	7.7e-11	8.70	8.3	7.2e-17	0.04	0.00	1.00	FALSE
10	GTEx	Artery Coronary	RP11-967K21.1	0.18	0.12	lasso	7	0.07	1.8e-03	8.17	8.3	7.3e-17	-0.50	0.40	0.30	FALSE
73	The Cancer Genome Atlas	Thyroid Carcinoma	ERGIC2	0.19	0.10	blup	62	0.11	1.1e-10	7.85	-8.2	2.1e-16	-0.03	0.01	0.99	FALSE
34	GTEx	Esophagus Muscularis	RP11-996F15.2	0.56	0.45	enet	31	0.47	1.3e-31	8.70	8.2	3.0e-16	0.01	0.00	1.00	FALSE
14	GTEx	Brain Cerebellar Hemisphere	RP11-996F15.2	0.30	0.11	enet	24	0.17	3.7e-05	8.70	8.1	4.0e-16	0.02	0.01	0.98	FALSE
42	GTEx	Ovary	RP11-996F15.2	0.50	0.46	enet	22	0.54	1.1e-15	7.85	7.9	3.0e-15	0.05	0.01	0.99	FALSE
48	GTEx	Skin Not Sun Exposed Suprapubic	RP11-996F15.2	0.44	0.28	enet	55	0.28	1.1e-15	8.70	7.9	3.6e-15	0.01	0.00	1.00	FALSE
37	GTEx	Lung	CCDC91	0.14	0.00	enet	33	0.06	1.5e-05	-6.59	-7.8	5.6e-15	0.31	0.24	0.21	FALSE
11	GTEx	Artery Coronary	RP11-996F15.2	0.54	0.44	enet	20	0.43	9.0e-16	8.83	7.6	2.6e-14	0.03	0.00	1.00	FALSE
59	GTEx	Vagina	RP11-996F15.2	0.44	0.31	enet	23	0.27	5.9e-07	8.83	7.6	3.4e-14	0.03	0.00	0.99	FALSE
20	GTEx	Cells Transformed fibroblasts	ERGIC2	0.12	0.03	enet	23	0.05	1.4e-04	8.70	-7.2	5.5e-13	0.00	0.01	0.99	FALSE
29	GTEx	Esophagus Mucosa	MRPS35	0.18	0.00	enet	20	0.01	6.6e-02	0.96	6.5	9.9e-11	-0.37	0.02	0.81	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	ERGIC2	0.06	0.02	enet	9	0.04	4.8e-05	4.51	-6.3	2.9e-10	-0.06	0.01	0.92	FALSE
5	GTEx	Adrenal Gland	RP11-967K21.1	0.22	0.02	lasso	4	0.02	6.5e-02	7.98	6.3	3.6e-10	-0.45	0.12	0.06	FALSE
58	GTEx	Uterus	RP11-996F15.2	0.37	0.08	enet	16	0.22	3.3e-05	8.70	6.2	5.6e-10	0.03	0.01	0.96	FALSE
65	The Cancer Genome Atlas	Breast Invasive Carcinoma	ERGIC2	0.03	0.00	blup	62	0.02	2.6e-04	-3.86	-6.0	1.6e-09	0.01	0.03	0.53	FALSE
33	GTEx	Esophagus Muscularis	RP11-860B13.1	0.19	0.07	enet	24	0.06	2.1e-04	1.22	-6.0	2.5e-09	0.32	0.26	0.66	FALSE
56	GTEx	Thyroid	RP11-967K21.1	0.05	0.00	enet	7	0.00	2.8e-01	6.90	5.6	2.0e-08	-0.38	0.09	0.39	FALSE
61	METSIM	Adipose	FAR2	0.05	0.02	enet	10	0.03	6.2e-05	4.48	5.2	1.8e-07	0.06	0.96	0.03	FALSE