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chr12:12,175,854-15,743,444

Best TWAS P=5.72e-15 · Best GWAS P=5.29e-20 conditioned to 1.25e-11

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C12orf60	0.28	0.25	lasso	4	0.24	2.0e-29	6.4	6.8	8.0e-12	-0.01	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	KIAA1467	0.21	0.07	enet	17	0.06	1.5e-05	-5.8	-5.8	5.2e-09	0.00	0.98	0.00	FALSE
3	GTEx	Adipose Visceral Omentum	WBP11	0.15	0.11	lasso	4	0.12	8.7e-07	-5.5	6.7	2.8e-11	0.04	0.28	0.20	FALSE
4	GTEx	Artery Aorta	KIAA1467	0.31	0.03	enet	27	0.08	5.3e-05	-5.0	-6.5	9.2e-11	-0.02	0.89	0.00	FALSE
5	GTEx	Artery Tibial	KIAA1467	0.21	0.12	lasso	4	0.15	5.3e-12	-5.8	-6.3	3.3e-10	-0.02	1.00	0.00	FALSE
6	GTEx	Artery Tibial	WBP11	0.09	0.06	lasso	2	0.06	3.8e-05	-5.7	6.2	4.0e-10	0.00	0.93	0.00	FALSE
7	GTEx	Brain Caudate basal ganglia	C12orf60	0.39	0.34	lasso	3	0.32	5.4e-10	6.4	6.2	4.1e-10	0.00	0.97	0.00	FALSE
8	GTEx	Brain Cerebellar Hemisphere	C12orf60	0.36	0.27	lasso	5	0.33	3.8e-09	6.4	5.3	9.4e-08	-0.02	0.88	0.01	FALSE
9	GTEx	Brain Cerebellum	C12orf60	0.19	0.17	lasso	3	0.13	1.2e-04	6.4	6.1	1.1e-09	-0.02	0.18	0.05	FALSE
10	GTEx	Brain Cortex	C12orf60	0.44	0.28	lasso	3	0.29	1.2e-08	6.4	6.7	2.2e-11	-0.01	0.79	0.02	FALSE
11	GTEx	Brain Cortex	RP11-695J4.2	0.41	0.04	lasso	14	0.09	1.7e-03	3.3	6.6	4.2e-11	-0.01	0.05	0.07	FALSE
12	GTEx	Brain Hypothalamus	C12orf60	0.28	0.27	lasso	4	0.19	3.8e-05	6.4	6.3	3.2e-10	-0.01	0.25	0.05	FALSE
13	GTEx	Brain Nucleus accumbens basal ganglia	RP11-174G6.5	0.23	0.13	lasso	4	0.11	8.9e-04	-5.9	5.7	1.4e-08	0.00	0.21	0.08	FALSE
14	GTEx	Brain Putamen basal ganglia	C12orf60	0.33	0.32	lasso	3	0.29	1.5e-07	6.4	6.5	1.1e-10	-0.02	0.41	0.04	FALSE
15	GTEx	Breast Mammary Tissue	HTR7P1	0.19	0.10	lasso	3	0.12	1.2e-06	-5.3	-5.2	1.5e-07	-0.05	0.31	0.04	FALSE
16	GTEx	Breast Mammary Tissue (Male)	KIAA1467	0.21	0.02	lasso	7	0.00	3.3e-01	-5.8	6.5	1.0e-10	-0.02	0.07	0.05	FALSE
17	GTEx	Breast Mammary Tissue (Female)	C12orf60	0.19	0.17	lasso	3	0.12	2.6e-04	6.4	6.4	1.3e-10	-0.01	0.16	0.07	FALSE
18	GTEx	Cells Transformed fibroblasts	KIAA1467	0.21	0.09	lasso	7	0.18	1.3e-13	-5.8	-7.0	1.8e-12	-0.01	1.00	0.00	TRUE
19	GTEx	Cells Transformed fibroblasts	C12orf60	0.10	0.10	lasso	2	0.09	1.8e-07	6.5	6.7	1.7e-11	-0.03	1.00	0.00	FALSE
20	GTEx	Heart Left Ventricle	KIAA1467	0.45	0.21	lasso	6	0.23	1.1e-12	-5.8	-5.9	3.7e-09	0.00	1.00	0.00	FALSE
21	GTEx	Heart Left Ventricle	C12orf60	0.24	0.23	lasso	5	0.26	7.1e-14	6.4	6.4	1.5e-10	0.00	1.00	0.00	FALSE
22	GTEx	Heart Left Ventricle	H2AFJ	0.16	0.07	lasso	8	0.05	1.1e-03	-5.3	-5.3	1.4e-07	0.03	0.90	0.00	FALSE
23	GTEx	Liver	H2AFJ	0.18	0.11	lasso	8	0.04	2.7e-02	-5.3	-5.2	2.7e-07	0.04	0.15	0.05	FALSE
24	GTEx	Lung	KIAA1467	0.15	0.06	lasso	5	0.08	8.6e-07	-4.0	-6.0	1.7e-09	0.02	0.81	0.02	FALSE
25	GTEx	Muscle Skeletal	WBP11	0.08	0.08	lasso	5	0.08	2.4e-08	-5.5	6.0	1.9e-09	0.01	0.98	0.00	FALSE
26	GTEx	Muscle Skeletal	C12orf60	0.23	0.10	lasso	4	0.12	1.1e-11	6.4	6.5	9.6e-11	0.00	1.00	0.00	FALSE
27	GTEx	Nerve Tibial	KIAA1467	0.14	0.07	enet	14	0.06	2.3e-05	-5.7	-6.3	2.2e-10	0.02	1.00	0.00	FALSE
28	GTEx	Nerve Tibial	WBP11	0.11	0.10	lasso	3	0.09	1.0e-06	-5.7	5.4	5.6e-08	0.00	0.96	0.00	FALSE
29	GTEx	Nerve Tibial	C12orf60	0.39	0.27	enet	11	0.30	9.6e-22	6.4	6.4	1.4e-10	-0.02	1.00	0.00	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	C12orf60	0.15	0.16	lasso	2	0.13	1.6e-07	6.4	6.7	3.0e-11	-0.03	0.98	0.00	FALSE
31	GTEx	Skin Sun Exposed Lower leg	C12orf60	0.09	0.06	enet	11	0.05	4.0e-05	6.4	7.3	3.1e-13	-0.02	0.94	0.00	FALSE
32	GTEx	Stomach	KIAA1467	0.30	0.12	lasso	11	0.12	2.8e-06	-5.8	-6.7	2.9e-11	0.00	0.95	0.00	FALSE
33	GTEx	Testis	KIAA1467	0.25	0.11	lasso	9	0.08	2.4e-04	-5.8	-5.8	5.3e-09	0.01	0.84	0.02	FALSE
34	GTEx	Thyroid	KIAA1467	0.15	0.03	enet	17	0.08	8.4e-07	-5.1	-6.1	9.2e-10	-0.04	0.99	0.00	FALSE
35	GTEx	Thyroid	C12orf60	0.16	0.10	enet	9	0.12	8.1e-10	6.5	6.6	5.1e-11	-0.03	1.00	0.00	FALSE
36	METSIM	Adipose	C12orf60	0.14	0.10	lasso	4	0.08	1.2e-12	6.4	6.4	1.4e-10	-0.01	1.00	0.00	FALSE
37	METSIM	Adipose	MGP	0.04	0.04	bslmm	359	0.04	6.2e-07	-2.9	5.3	1.2e-07	0.00	1.00	0.00	FALSE
38	NTR	Blood	PLBD1	0.09	0.08	enet	22	0.11	1.8e-33	-7.9	7.8	5.7e-15	0.08	0.06	0.94	TRUE
39	ROSMAP	Brain Pre-frontal Cortex	WBP11	0.10	0.05	lasso	4	0.06	1.2e-08	-5.7	6.8	1.0e-11	-0.02	1.00	0.00	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	C12orf60	0.26	0.29	lasso	5	0.29	1.9e-37	6.4	6.3	2.6e-10	-0.02	1.00	0.00	FALSE
41	YFS	Blood	CDKN1B	0.03	0.03	enet	15	0.03	2.1e-10	-7.8	5.4	5.8e-08	-0.37	0.99	0.01	TRUE
42	YFS	Blood	H2AFJ	0.05	0.02	bslmm	360	0.03	2.9e-10	-5.3	-6.5	8.4e-11	-0.01	1.00	0.00	FALSE
43	YFS	Blood	KIAA1467	0.04	0.01	enet	21	0.03	1.7e-09	-4.8	-5.7	1.5e-08	0.04	0.98	0.00	FALSE
44	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C12orf60	0.17	0.03	blup	56	0.07	2.9e-06	6.5	6.6	3.2e-11	-0.02	0.00	0.99	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	C12orf60	0.05	0.04	enet	4	0.04	7.3e-09	6.4	6.0	1.6e-09	-0.02	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	HEBP1	0.03	0.02	lasso	3	0.01	1.8e-03	-5.7	5.9	3.7e-09	-0.01	0.00	0.99	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	HTR7P1	0.07	0.03	blup	62	0.06	2.8e-12	-5.3	6.4	1.5e-10	0.01	0.18	0.82	FALSE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	HEBP1	0.19	0.21	blup	67	0.22	1.1e-12	-5.1	-5.4	7.2e-08	-0.04	0.17	0.83	FALSE
49	The Cancer Genome Atlas	Glioblastoma Multiforme	C12orf60	0.24	0.09	enet	11	0.13	1.2e-04	6.4	5.7	1.1e-08	-0.02	0.01	0.83	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C12orf60	0.10	0.04	enet	7	0.05	2.0e-06	-6.3	6.7	2.5e-11	-0.05	0.01	0.98	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C12orf60	0.07	0.08	lasso	3	0.07	1.1e-08	6.4	6.2	7.0e-10	-0.02	0.01	0.99	FALSE
52	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C12orf60	0.12	0.07	enet	8	0.07	5.4e-05	6.4	7.1	1.4e-12	-0.03	0.01	0.98	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	C12orf60	0.14	0.14	lasso	4	0.13	2.2e-14	6.4	6.7	2.2e-11	-0.02	0.01	0.99	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	WBP11	0.03	0.03	blup	57	0.02	2.3e-03	-5.3	5.9	3.4e-09	-0.04	0.11	0.22	FALSE
55	The Cancer Genome Atlas	Lung Adenocarcinoma	C12orf60	0.07	0.05	enet	7	0.05	1.5e-06	6.4	6.6	3.6e-11	-0.01	0.01	0.99	FALSE
56	The Cancer Genome Atlas	Lung Adenocarcinoma	GPR19	0.06	0.00	blup	65	0.01	8.6e-03	-9.2	-5.2	1.5e-07	0.79	0.00	0.97	TRUE
57	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C12orf60	0.05	0.05	lasso	3	0.04	1.1e-05	6.4	6.5	1.1e-10	-0.01	0.01	0.99	FALSE
58	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HTR7P1	0.03	0.04	lasso	1	0.03	1.4e-04	-5.1	5.2	2.6e-07	0.05	0.17	0.70	FALSE
59	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C12orf60	0.10	0.01	blup	56	0.07	1.6e-05	6.5	5.9	3.7e-09	-0.04	0.01	0.89	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	C12orf60	0.05	0.03	lasso	1	0.01	1.2e-02	6.4	6.4	1.8e-10	-0.02	0.01	0.94	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	KIAA1467	0.03	0.02	blup	49	0.01	3.9e-02	-5.2	-5.9	4.2e-09	-0.03	0.04	0.21	FALSE
62	The Cancer Genome Atlas	Testicular Germ Cell Tumors	HEBP1	0.17	0.08	blup	68	0.09	3.6e-04	-4.0	-5.4	6.6e-08	-0.03	0.12	0.32	FALSE
63	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MANSC1	0.22	0.04	lasso	4	0.05	7.7e-03	5.1	-5.3	1.4e-07	0.04	0.00	0.65	TRUE
64	The Cancer Genome Atlas	Thyroid Carcinoma	C12orf60	0.16	0.16	enet	10	0.18	1.3e-17	6.4	7.4	1.6e-13	-0.03	0.01	0.99	TRUE