Hub : Genes

RP11-950C14.3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1270 0.0370 4.3e-10 0.187 NA 0.157 NA 0.070 3.4e-15 NA 8.5e-13 NA 2.4e-06
2 GTEx Adipose Visceral Omentum 0.0830 0.0410 2.7e-03 0.078 NA 0.042 NA -0.002 7.2e-05 NA 3.1e-03 NA 4.6e-01
3 GTEx Artery Aorta 0.1730 0.0470 7.4e-10 0.111 NA 0.137 NA 0.156 1.1e-06 NA 5.3e-08 NA 6.0e-09
4 GTEx Artery Tibial 0.0873 0.0401 5.0e-03 0.003 NA -0.003 NA 0.000 1.8e-01 NA 7.6e-01 NA 3.2e-01
5 GTEx Breast Mammary Tissue 0.1120 0.0410 8.6e-05 0.110 NA 0.093 NA 0.076 2.7e-06 NA 1.7e-05 NA 1.0e-04
6 GTEx Breast Mammary Tissue (Female) 0.1253 0.0601 6.6e-03 0.049 NA 0.061 NA 0.044 1.4e-02 NA 6.9e-03 NA 1.9e-02
7 GTEx Cells Transformed fibroblasts 0.0780 0.0300 1.9e-04 0.066 NA 0.058 NA 0.025 1.1e-05 NA 3.6e-05 NA 5.3e-03
8 GTEx Colon Sigmoid 0.1000 0.0550 7.3e-03 0.048 NA 0.047 NA 0.012 8.8e-03 NA 9.0e-03 NA 1.2e-01
9 GTEx Colon Transverse 0.0760 0.0360 4.6e-03 0.100 NA 0.053 NA 0.088 1.8e-05 NA 1.6e-03 NA 5.6e-05
10 GTEx Esophagus Gastroesophageal Junction 0.1450 0.0700 6.6e-03 0.000 NA -0.007 NA -0.003 3.3e-01 NA 7.7e-01 NA 4.5e-01
11 GTEx Esophagus Mucosa 0.1380 0.0430 1.1e-07 0.113 NA 0.129 NA 0.020 5.7e-08 NA 6.2e-09 NA 1.6e-02
12 GTEx Esophagus Muscularis 0.1570 0.0550 3.6e-05 0.079 NA 0.063 NA 0.014 1.5e-05 NA 1.1e-04 NA 4.2e-02
13 GTEx Heart Atrial Appendage 0.1390 0.0540 2.2e-04 0.130 NA 0.113 NA 0.117 1.9e-06 NA 9.5e-06 NA 6.2e-06
14 GTEx Heart Left Ventricle 0.1202 0.0497 3.2e-04 0.035 NA 0.031 NA 0.008 5.6e-03 NA 8.8e-03 NA 1.2e-01
15 GTEx Lung 0.0400 0.0203 7.1e-03 0.054 NA 0.031 NA 0.043 5.6e-05 NA 1.9e-03 NA 3.0e-04
16 GTEx Nerve Tibial 0.0943 0.0321 6.9e-06 0.126 NA 0.115 NA -0.001 3.2e-09 NA 1.7e-08 NA 4.3e-01
17 GTEx Skin Not Sun Exposed Suprapubic 0.0730 0.0350 2.8e-03 0.026 NA 0.027 NA 0.018 1.4e-02 NA 1.2e-02 NA 3.3e-02
18 GTEx Spleen 0.2780 0.0930 2.7e-04 0.098 NA 0.055 NA 0.020 1.8e-03 NA 1.6e-02 NA 1.0e-01
19 GTEx Testis 0.1480 0.0510 5.6e-06 0.127 NA 0.133 NA 0.113 3.0e-06 NA 1.8e-06 NA 1.1e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
Bipolar Disorder (2018) 0.3 0.5 1.6 -0.8 -0.4 -0.9 0.6 -0.6 -1.1 -1.0 -0.9 0.1 -0.1 -0.3 0.6 -0.6 -0.2 -0.6 -0.7 -1.3 0.0 -0.9
Bipolar Disorder or Schizophrenia 1.2 2.8 5.7 -2.0 -1.8 -1.2 1.6 -1.8 -2.1 -2.4 -1.4 -1.1 -1.6 -1.5 -1.2 -1.9 -1.4 -1.8 -1.8 -1.8 -0.9 -2.1
Depressed Affect (Nagel 2018) 3.0 6.3 15.5 2.2 2.1 3.9 -1.8 2.4 2.6 3.0 2.8 1.9 1.8 2.3 1.7 2.2 2.8 2.5 2.6 3.2 2.5 2.4
Depression (Nagel 2018) 0.1 0.2 0.6 -0.2 0.1 0.5 0.0 0.1 0.1 0.6 0.2 0.0 -0.3 -0.5 0.2 0.3 0.5 0.4 0.4 0.8 0.6 -0.2
Intelligence (Savage-Jansen 2018) 0.8 2.3 5.7 -0.8 -1.3 -1.4 1.4 -1.4 -1.9 -2.3 -1.6 -1.3 -1.4 -1.2 -1.2 -1.3 -1.4 -1.6 -1.3 -2.4 -1.4 -1.6
Neuroticism (Nagel 2018) 4.5 10.5 24.4 3.0 2.8 4.9 -2.7 3.1 3.3 3.1 3.6 2.7 2.8 3.0 1.9 3.0 3.6 3.0 3.2 3.9 3.4 3.4
Schizophrenia (2018) 1.4 2.9 5.0 -1.9 -2.0 -0.9 1.6 -1.9 -1.8 -2.2 -1.1 -1.5 -2.0 -1.6 -1.8 -1.9 -1.6 -1.8 -1.6 -1.3 -1.2 -2.0
Schizophrenia vs Biploar Disorder 0.1 0.2 0.8 0.0 -0.3 0.9 0.6 -0.2 0.0 -0.1 0.3 -0.3 -0.6 0.1 -0.7 -0.2 -0.6 -0.2 -0.0 0.5 -0.6 0.0
Worry (Nagel 2018) 5.3 11.2 20.8 3.1 2.9 4.6 -2.9 3.1 3.1 2.8 3.5 3.6 3.1 3.4 2.5 3.0 4.0 2.9 3.1 4.3 3.7 3.2
Alzheimer’s Disease (in mother) 0.5 0.6 2.2 -0.8 -0.6 -1.0 -0.1 -0.7 -0.5 -1.4 -0.1 -0.8 -0.8 -0.8 -0.3 -0.6 -1.0 -0.4 -0.5 -1.5 -0.6 -0.6
Alzheimer’s Disease (in father) 0.2 0.2 1.2 0.0 -0.1 -0.1 -0.3 0.1 0.1 0.3 0.5 0.2 0.4 -0.1 -1.1 0.2 -0.3 0.2 -0.6 0.8 0.3 0.1
Alzheimer’s Disease (including proxy) 0.5 0.7 1.1 -1.0 -1.0 -1.0 0.4 -0.9 -0.5 -0.7 -0.4 -1.0 -0.8 -0.8 -0.7 -1.0 -0.9 -0.7 -0.8 -0.8 -0.9 -0.7
Crohns Disease (2017) 0.6 1.2 4.0 1.3 1.0 0.9 -0.6 1.1 1.2 0.5 1.1 1.3 0.8 2.0 0.8 0.8 1.0 1.0 1.3 1.2 1.0 1.5
Irritable Bowel Disease (IBD) 0.3 0.7 1.5 -1.2 -0.9 -1.0 0.9 -1.0 -0.9 -0.5 -0.3 -0.5 -0.6 -0.8 -0.4 -1.2 -0.9 -1.0 -0.9 -0.7 -0.1 -0.6
Ulcerative Colitis (UC) 2.4 4.5 8.3 -2.9 -2.3 -2.2 2.2 -2.4 -2.3 -1.1 -1.7 -1.9 -1.7 -2.7 -1.1 -2.7 -2.1 -2.4 -2.4 -1.8 -0.9 -2.2
Major Depression (MDD) 0.3 0.4 2.1 0.6 0.3 1.1 -0.0 0.4 -0.1 -0.2 0.6 0.9 0.3 0.8 0.3 0.5 0.3 0.3 -0.0 1.4 0.7 -0.1
Reaction Time 2.2 4.3 6.8 -2.2 -2.3 -2.6 2.3 -2.0 -2.0 -2.6 -2.3 -1.7 -1.9 -2.0 -1.6 -1.6 -2.0 -2.2 -2.4 -1.2 -1.8 -2.0
Verbal and Numeric Reasoning (VNR) 0.5 1.2 7.5 -0.2 -0.4 -1.3 0.6 -0.7 -1.5 -2.0 -1.0 -0.6 -0.6 -0.6 -0.3 -0.5 -1.3 -1.0 -0.8 -2.7 -0.9 -0.9
Breast Cancer 0.7 1.7 3.5 1.2 1.5 1.1 -1.2 1.3 1.4 0.5 1.3 1.3 1.9 1.5 0.8 1.4 0.7 1.4 0.9 0.7 1.9 1.6
Ovarian Cancer 0.8 1.1 2.8 1.2 0.9 0.9 -1.3 0.9 1.1 1.2 1.4 1.4 0.3 1.0 0.8 0.8 1.0 1.1 0.8 1.7 -0.1 0.6
Prostate Cancer 1.9 2.7 5.2 2.3 1.7 2.1 -1.7 1.7 1.4 0.8 2.0 1.7 1.2 2.1 1.0 1.5 1.0 1.6 1.5 2.2 1.4 1.7
Age at First Birth 5.5 7.9 10.9 3.0 3.2 2.4 -2.8 3.0 2.7 2.0 2.6 3.0 3.2 3.3 2.8 3.0 2.9 2.9 3.2 1.3 2.3 3.1
Bipolar Disorder (2011) 1.8 1.7 3.7 -1.2 -1.2 -1.0 1.3 -1.3 -1.1 -1.9 -1.2 -1.0 -0.9 -1.3 -1.0 -1.4 -1.4 -1.1 -1.6 -1.7 -1.1 -1.5
Body Mass Index (BMI) (2010) 0.1 0.2 0.8 0.3 0.5 0.2 -0.9 0.3 -0.1 0.6 0.2 0.9 0.5 -0.0 0.5 0.3 0.1 0.4 0.1 0.7 0.3 0.1
Coronary Artery Disease (CAD) 7.6 9.0 13.3 2.7 3.1 3.6 -3.0 3.1 3.1 1.8 3.1 2.7 3.4 3.0 2.7 3.0 2.8 3.1 2.9 2.7 3.2 3.4
Crohns Disease (2012) 1.2 2.0 4.4 1.5 1.3 1.2 -1.0 1.5 1.6 0.7 1.5 1.4 2.0 2.1 0.9 1.3 1.4 1.2 1.7 0.9 0.9 1.8
Mean Putamen Volume 0.2 0.3 0.8 -0.5 -0.6 -0.2 0.9 -0.5 -0.2 -0.3 -0.5 -0.7 -0.6 -0.5 -0.5 -0.7 -0.2 -0.6 -0.4 0.3 -0.2 -0.6
Fasting Glucose 0.4 0.5 1.2 -1.0 -0.8 -1.1 1.1 -0.7 -0.1 -0.3 -0.9 -0.5 -0.4 0.0 -0.4 -0.9 -1.0 -0.6 -1.0 -0.2 -0.8 -0.7
HbA1C 0.3 0.3 1.7 -0.5 -0.3 -0.5 0.1 -0.3 -0.5 -1.3 -0.8 -0.1 0.5 0.4 -0.1 -0.3 -1.1 -0.4 -0.7 -0.5 -0.1 -0.3
HDL Cholesterol 0.1 0.1 0.6 -0.0 -0.0 -0.5 -0.1 -0.1 -0.0 -0.8 -0.3 -0.1 -0.3 0.1 -0.7 0.1 -0.3 -0.2 -0.1 -0.6 -0.3 0.2
LDL Cholesterol 0.2 0.3 1.2 -0.4 -0.5 -0.7 0.7 -0.3 -0.3 -0.0 -1.1 -0.4 0.1 -0.4 -1.1 -0.2 0.3 -0.6 0.0 -0.3 0.3 -0.1
Lupus 1.5 2.2 5.4 1.1 1.3 1.6 -0.6 1.7 2.3 1.0 1.6 0.8 1.5 1.9 1.1 1.4 1.6 1.5 1.8 1.4 0.9 2.1
Neuroticism (2016) 0.6 0.9 4.0 1.3 0.7 2.0 -0.8 0.7 0.6 -0.4 1.3 0.5 0.3 1.1 0.1 0.9 0.0 0.8 0.5 1.3 0.7 1.2
Primary Biliary Cirrhosis 2.1 3.0 8.6 1.4 1.8 2.0 -0.7 1.7 1.5 1.6 1.8 1.9 1.5 1.4 2.9 1.9 1.8 1.6 1.9 -0.1 1.9 1.8
Rheumatoid Arthritis 5.1 7.0 9.4 -3.0 -2.8 -2.1 2.5 -3.0 -3.1 -1.8 -3.0 -3.0 -2.3 -2.9 -2.4 -2.8 -1.9 -3.0 -2.3 -2.9 -2.3 -2.7
Schizophrenia (2014) 0.2 0.4 1.4 -0.6 -0.7 0.8 0.5 -0.6 -0.7 -1.2 0.1 -0.4 -0.7 -0.1 -1.0 -0.6 -1.0 -0.5 -0.7 -0.1 -0.2 -0.5
Triglycerides 1.4 2.2 4.3 1.6 1.3 2.1 -0.7 1.5 1.4 1.4 1.7 1.2 1.5 1.1 1.0 1.5 1.5 1.4 1.5 1.9 2.0 1.2
Type 2 Diabetes (T2D) (2012) 1.2 1.4 3.8 -1.7 -1.0 -1.5 1.0 -1.2 -1.9 -1.4 -0.8 -0.4 -1.1 -1.4 -0.5 -1.0 -0.8 -1.4 -1.3 -1.1 -0.3 -1.4
Ulcerative Colitis 0.3 0.4 2.2 -1.0 -0.3 -0.5 -0.0 -0.5 -0.6 0.1 0.5 -0.4 0.5 -1.5 0.3 -0.6 -0.8 -0.3 -0.6 -0.9 0.6 -0.4
Blood Eosinophil Count 0.2 1.9 8.9 -1.5 -1.0 -1.5 0.7 -1.0 -0.5 -1.1 -1.2 -1.5 -1.5 -3.0 -1.2 -1.1 -1.4 -1.0 -1.5 0.2 -2.0 -0.9
Blood Platelet Count 1.3 15.6 31.6 -3.9 -3.8 -5.6 3.2 -3.8 -3.9 -3.2 -3.5 -3.5 -3.4 -4.3 -3.5 -3.8 -3.5 -3.8 -4.1 -5.6 -3.6 -3.8
Blood Red Count 0.5 4.9 9.0 -2.0 -2.6 -1.5 2.8 -2.3 -2.1 -3.0 -2.2 -2.2 -2.4 -2.6 -1.7 -2.1 -1.8 -2.5 -1.9 -1.4 -1.6 -2.7
Blood White Count 0.5 3.4 7.1 -1.4 -1.5 -2.4 1.9 -1.6 -1.5 -1.8 -1.5 -1.9 -1.7 -2.7 -1.6 -1.6 -2.4 -1.5 -2.2 -1.7 -2.1 -1.6
Heel T-Score 8.5 67.9 88.2 8.6 8.9 8.6 -7.9 8.8 8.1 7.2 9.3 8.3 9.4 7.7 8.0 8.6 7.1 8.7 8.0 6.6 7.8 8.4
BMI 0.4 2.3 5.3 -1.5 -1.9 -1.2 1.8 -2.0 -2.0 -1.1 -1.3 -1.1 -1.6 -1.6 -0.1 -2.0 -1.1 -1.8 -1.7 -0.1 -0.6 -2.3
Height 1.2 22.8 67.9 -6.0 -4.1 -4.1 2.3 -4.5 -4.4 -3.3 -5.1 -4.7 -2.5 -6.2 -5.1 -4.5 -4.9 -4.6 -4.5 -8.2 -4.8 -3.4
Waist Hip Ratio (WHR) 0.3 1.3 3.5 -1.5 -1.5 -0.5 0.5 -1.1 -0.9 -0.3 -0.8 -0.9 -1.9 -1.8 -1.4 -1.0 -0.5 -1.4 -1.1 1.4 -0.4 -0.9
Systolic Blood Pressure 5.8 28.9 42.1 5.2 5.5 4.9 -4.9 5.7 5.4 5.3 5.8 5.9 4.7 5.1 5.5 5.5 4.3 5.7 4.5 6.5 6.1 5.2
Smoking Status 0.1 0.1 0.5 0.0 -0.4 0.7 0.1 -0.4 -0.3 -0.4 0.3 -0.2 -0.0 -0.0 -0.6 -0.5 0.5 -0.5 -0.1 0.4 -0.2 -0.1
Allergy or Eczema 0.7 1.9 5.4 -1.2 -1.1 -1.4 0.5 -1.2 -1.4 -2.1 -1.1 -1.0 -0.8 -1.6 -1.1 -1.1 -2.3 -1.1 -2.1 -0.6 -1.3 -1.4
Cardiovascular Disease 1.3 4.2 8.7 1.9 2.0 2.0 -2.3 2.0 1.9 2.9 2.4 1.9 1.8 1.6 1.1 1.8 2.1 2.0 1.9 2.5 2.1 2.1
Hypothyroidism (self reported) 5.7 13.1 17.6 3.8 3.7 4.2 -3.5 3.8 3.9 3.4 4.2 3.0 3.9 3.3 3.4 3.5 2.8 3.8 3.3 3.6 3.5 4.0
Respiratory disease 0.1 0.3 0.8 -0.4 -0.7 0.4 0.3 -0.4 -0.3 -0.7 -0.5 -0.3 -0.6 -0.8 -0.5 -0.2 0.0 -0.6 -0.7 0.7 0.9 -0.5
Type 2 Diabetes (T2D) (2018) 0.1 0.1 0.8 0.0 0.2 -0.1 -0.1 0.1 -0.0 0.2 0.7 0.5 -0.1 -0.5 0.6 0.3 0.2 0.3 -0.1 -0.1 0.9 0.1
Lung FEV1/FVC ratio 0.2 0.8 4.4 -0.2 0.5 -2.1 1.1 0.1 -0.2 -0.6 -1.0 -0.1 1.4 0.1 1.6 0.5 0.0 0.3 0.2 -1.9 -0.7 0.1
Lung FVC 1.5 7.6 14.4 -2.9 -3.5 -2.5 3.4 -3.3 -2.8 -2.7 -3.1 -2.3 -3.8 -1.3 -1.8 -3.4 -1.9 -3.1 -2.3 0.5 -2.1 -3.3
Neuroticism 3.3 8.1 21.8 2.3 2.1 4.5 -1.9 2.5 2.7 2.3 3.4 2.4 2.5 2.3 2.0 2.4 3.0 2.2 2.4 4.7 3.5 2.8
Chronotype (morning person) 0.3 0.7 1.4 1.2 1.1 0.6 -0.6 0.7 0.8 0.9 0.6 0.9 0.9 1.1 0.7 0.6 0.6 0.9 1.0 -0.9 -0.2 0.9
Hair Pigment 0.0 1.3 2.5 1.3 1.0 1.2 -1.0 1.1 1.6 1.2 0.7 0.8 0.8 1.0 -0.3 1.0 1.0 1.2 1.4 1.4 1.3 1.2
Tanning 0.2 2.7 5.8 -1.3 -1.6 -2.3 1.7 -1.5 -1.0 -1.2 -1.5 -1.6 -1.7 -1.2 -1.5 -1.8 -1.7 -1.2 -1.6 -2.0 -2.4 -1.5
Hand grip strength (left) 1.9 5.0 11.6 1.7 2.2 3.0 -2.0 2.3 2.0 0.7 1.9 1.9 2.9 1.6 2.7 2.0 0.8 2.1 1.3 3.4 3.4 2.3
Number of treatments/medications taken 3.5 6.4 15.0 2.7 2.0 3.6 -2.6 2.2 2.0 2.6 2.8 2.4 1.9 2.1 1.0 1.9 2.8 2.3 2.4 3.9 2.8 2.4
Average weekly spirits intake 6.3 7.8 11.9 -2.5 -2.7 -3.1 2.7 -3.0 -3.5 -3.0 -2.5 -2.2 -3.0 -2.5 -2.8 -3.1 -2.6 -2.6 -2.6 -2.7 -2.7 -2.8
Sensitivity / hurt feelings 1.0 1.7 4.6 1.2 1.0 1.9 -0.9 1.1 1.3 1.3 1.3 0.9 1.0 1.2 1.4 1.1 1.4 1.0 1.3 2.1 1.1 1.3
Frequency of depressed mood in last 2 weeks 0.6 0.8 2.8 0.9 0.8 1.7 -0.3 0.9 0.6 0.6 1.1 0.8 -0.0 0.5 0.7 1.1 0.5 1.0 0.8 1.2 1.4 0.9
Hearing difficulty/problems: Yes 5.3 8.1 13.7 -2.8 -3.1 -2.6 2.2 -3.2 -3.3 -1.2 -3.3 -2.6 -3.4 -3.3 -3.7 -3.3 -2.4 -3.1 -2.7 -1.3 -2.5 -2.9
Relative age of first facial hair 0.2 0.4 1.4 -0.6 -0.6 -0.5 0.3 -0.6 -0.6 0.5 -1.2 -0.3 -0.0 -1.0 -0.1 -0.6 0.1 -0.8 -0.3 -0.9 -0.5 -0.3
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 2.3 0.0 -0.3 0.7 0.1 -0.3 0.0 0.6 0.5 0.2 -0.8 0.5 -0.4 -0.5 0.6 -0.1 0.2 1.5 -0.1 0.3
Ever used hormone-replacement therapy (HRT) 0.2 0.3 1.5 0.7 0.0 0.9 0.1 0.2 0.2 0.1 0.1 0.8 -0.5 0.3 -0.3 0.1 1.2 0.2 0.8 0.3 0.6 0.4
Ever had hysterectomy (womb removed) 0.2 0.2 1.6 0.4 -0.1 0.5 0.5 -0.2 -0.4 -0.6 0.1 0.1 -0.6 -0.0 0.1 -0.2 0.3 -0.2 0.4 -0.5 -1.3 -0.1
Systolic blood pressure, automated reading 3.5 10.3 18.9 3.2 3.3 3.0 -2.9 3.4 2.9 2.9 3.2 3.8 2.7 2.6 3.8 3.5 2.8 3.3 2.6 3.3 4.4 2.8
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 1.0 0.1 0.5 0.7 -0.3 0.5 0.7 -0.2 0.3 -0.0 0.2 0.7 0.2 0.7 0.5 0.5 0.3 -0.2 -0.1 1.0
Angina 5.2 6.8 9.8 3.0 2.8 2.4 -2.7 2.5 2.0 2.7 2.9 3.1 2.8 2.8 2.1 2.4 2.1 2.7 2.5 2.6 2.5 2.6
Medication for hormone replacement therapy 1.0 1.1 2.8 0.7 0.9 1.1 -0.1 1.0 0.8 1.0 0.5 1.3 1.6 1.0 1.5 0.9 1.2 0.8 0.7 1.4 1.7 0.8
Vitamin and mineral supplements 0.4 0.5 2.1 0.4 0.6 0.5 0.2 0.5 0.7 1.5 0.7 0.7 -0.2 0.8 0.7 0.4 1.0 0.5 1.1 0.4 0.1 0.8
Supplements: Zinc 0.4 0.4 0.8 -0.6 -0.6 -0.8 0.4 -0.7 -0.8 -0.9 -0.9 -0.0 -0.6 -0.7 0.1 -0.7 -0.6 -0.7 -0.8 -0.6 0.8 -0.6
Medication: Co-codamol 0.6 0.7 2.0 1.0 0.6 1.4 -0.5 0.7 0.7 0.5 1.1 0.8 0.3 1.1 0.1 0.6 0.9 0.9 1.0 1.1 0.7 0.9
Medication: Metformin 0.5 0.7 2.8 0.7 0.6 0.3 -0.6 0.5 0.6 1.0 0.6 1.1 0.4 0.5 0.7 0.8 1.7 0.8 1.0 1.1 0.9 0.4
Diabetes (father) 0.5 0.7 1.2 -0.9 -1.1 -0.4 0.9 -0.9 -0.8 -0.6 -1.0 -0.8 -0.6 -0.8 -0.7 -0.8 -0.6 -1.0 -1.1 0.6 -0.3 -0.9
Diabetes (mother) 0.1 0.1 0.2 -0.1 -0.2 -0.1 0.3 -0.3 -0.2 -0.1 0.1 -0.0 0.2 -0.2 -0.4 -0.4 -0.4 -0.3 -0.4 -0.2 0.1 -0.4
Severe depression (siblings) 1.9 2.1 4.6 1.4 1.5 1.8 -1.3 1.5 1.1 1.1 2.1 1.8 1.2 1.3 1.1 1.5 1.2 1.4 1.3 1.5 1.3 1.4
Pack years adult smoking proportion 0.2 0.3 0.9 -0.6 -0.4 -0.1 0.5 -0.5 -0.7 0.1 -0.7 -0.5 -0.8 -0.9 -0.8 -0.4 0.1 -0.3 -0.3 -0.7 0.2 -0.2
Impedance of leg (right) 3.8 18.3 24.3 3.9 4.3 4.6 -4.6 4.4 4.1 4.8 4.4 4.5 3.3 3.8 2.2 4.3 4.9 4.1 4.7 4.8 4.1 4.7
Leg fat-free mass (left) 2.4 12.7 20.8 -4.1 -3.4 -3.6 2.9 -3.7 -3.9 -3.2 -3.4 -3.5 -2.4 -4.2 -1.6 -3.6 -4.1 -3.6 -4.0 -4.6 -2.8 -3.9
Trunk fat percentage 0.1 0.3 0.7 -0.8 -0.8 0.1 0.2 -0.7 -0.7 -0.3 0.1 0.2 -0.7 -0.8 0.1 -0.7 0.3 -0.7 -0.4 0.7 0.6 -0.6
Hand grip strength (right) 1.3 3.5 8.2 1.3 1.9 2.1 -2.1 1.9 1.8 1.1 1.3 1.5 2.3 1.2 2.4 1.7 0.6 1.8 1.1 2.8 2.9 2.2
Townsend deprivation index at recruitment 0.3 0.5 1.3 0.9 0.3 1.2 -0.9 0.3 0.0 0.5 1.0 0.6 -0.0 0.2 -0.6 0.4 1.0 0.3 1.0 1.0 -0.6 0.5
Current tobacco smoking 0.4 0.6 1.4 -0.7 -1.0 -0.3 1.1 -0.9 -0.6 -0.4 -0.2 -0.8 -1.0 -0.8 -1.2 -1.2 -0.4 -0.8 -0.6 0.1 -1.0 -0.7
Average weekly fortified wine intake 1.4 1.6 3.0 1.3 1.3 0.6 -1.4 1.1 1.1 1.3 0.7 1.7 1.2 1.2 1.7 1.1 1.4 1.2 1.2 1.5 1.3 0.9
Maternal smoking around birth 0.1 0.2 0.9 -0.5 -0.4 0.4 -0.2 -0.3 -0.1 0.1 -0.2 -0.6 -0.1 -0.7 -0.4 -0.4 -1.0 -0.3 -0.4 -0.5 0.1 0.1
Fed-up feelings 5.7 10.3 22.0 3.2 2.9 4.7 -2.1 3.1 3.0 3.2 4.2 2.8 2.3 3.1 2.9 2.9 2.8 3.1 3.1 4.1 3.4 3.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 1.5 0.1 0.3 0.8 -0.1 0.4 0.2 1.1 0.8 0.3 -0.0 -0.5 0.2 0.4 0.3 0.6 0.5 1.2 0.6 0.1
Relative age voice broke 0.1 0.2 0.7 -0.2 -0.3 -0.3 -0.1 -0.3 -0.8 -0.0 -0.8 -0.1 0.2 -0.6 0.0 -0.5 -0.4 -0.3 -0.3 -0.6 -0.4 -0.7
Taking other prescription medications 3.4 5.2 15.2 2.2 1.8 3.4 -1.8 1.9 2.0 2.3 2.4 2.2 1.6 2.0 1.7 1.7 2.3 2.1 2.1 3.9 2.3 2.4
Age when periods started (menarche) 0.8 1.9 3.8 1.7 1.5 1.9 -1.5 1.5 1.1 1.3 0.9 1.1 1.1 1.0 0.7 1.6 1.6 1.3 1.6 1.1 1.7 1.3
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 1.0 0.2 -0.2 0.4 0.8 -0.3 -0.4 -1.0 -0.1 -0.0 -1.0 0.3 -0.3 -0.4 -0.3 -0.3 -0.2 -0.8 -0.5 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 6.0 13.7 18.6 4.0 4.2 3.9 -3.3 3.9 3.4 3.1 3.8 3.8 4.3 3.2 4.3 3.7 2.7 4.0 3.7 2.4 4.3 3.7
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.5 0.1 -0.2 -0.4 0.1 -0.0 0.2 -0.3 -0.0 -0.0 -0.6 -0.5 -0.0 -0.0 -0.4 -0.1 -0.2 0.1 -0.7 0.0
Qualifications: CSEs or equivalent 0.4 0.5 1.3 -0.4 -0.9 -0.6 0.2 -0.9 -0.7 -0.5 -0.2 -0.6 -1.1 -0.3 -0.9 -1.1 -0.1 -0.6 -0.7 0.6 -0.2 -1.0
Serious illness, injury or assault to yourself 1.1 1.3 2.9 -1.2 -1.2 -0.8 1.6 -1.3 -1.2 -0.2 -0.3 -0.9 -1.0 -0.8 -0.9 -1.4 -1.0 -1.2 -1.5 -1.3 -1.7 -0.9
High blood pressure 0.1 0.2 1.1 0.3 0.1 0.4 -0.3 0.0 -0.1 1.0 0.7 0.5 -0.1 -0.1 -0.4 -0.2 0.7 0.2 0.2 0.5 0.5 0.0
Hayfever, allergic rhinitis or eczema 1.3 2.7 5.3 -1.7 -1.5 -1.8 0.7 -1.7 -1.8 -1.8 -1.6 -1.4 -1.3 -1.8 -1.6 -1.6 -2.3 -1.6 -2.3 -0.8 -1.6 -1.8
Multivitamins +/- minerals 0.1 0.1 0.7 0.3 0.1 0.3 -0.6 0.2 -0.1 -0.8 -0.1 0.2 0.6 0.4 0.2 0.2 -0.5 0.1 -0.3 0.3 0.1 -0.2
Stomach or abdominal pain in last month 0.1 0.1 0.5 0.5 0.0 0.7 0.1 -0.0 -0.2 0.0 0.5 0.1 -0.3 -0.5 -0.2 -0.2 0.3 0.0 0.3 0.0 0.2 0.1
Supplements: Glucosamine 0.3 0.4 1.5 0.6 0.7 0.1 -0.5 0.6 0.6 0.6 0.5 0.7 0.7 0.6 1.2 0.5 0.4 0.8 0.4 -0.3 0.0 0.5
Diverticular disease/diverticulitis (self-reported) 1.9 2.3 4.9 -1.3 -1.4 -1.5 1.4 -1.7 -1.8 -1.0 -1.6 -1.6 -2.2 -1.4 -1.3 -1.6 -0.6 -1.6 -0.9 -1.7 -1.9 -1.1
Medication: Atenolol 3.5 4.3 8.1 2.1 1.9 2.2 -2.0 1.9 1.9 2.5 2.0 2.5 1.9 2.1 1.5 1.7 2.8 2.0 2.3 2.4 1.7 1.7
Medication: Levothyroxine sodium 4.8 8.1 11.0 3.1 3.0 3.1 -2.8 2.9 2.7 3.0 3.3 2.7 2.8 2.7 2.3 2.6 2.5 3.0 2.7 2.9 2.8 2.9
Sitting height 0.1 1.0 2.6 0.9 1.5 0.6 -1.6 1.1 0.4 0.2 1.1 1.0 1.5 0.9 1.1 1.3 -0.4 1.1 0.2 -0.7 0.7 1.0
Chronic bronchitis/emphysema (father) 0.1 0.1 1.2 0.1 0.1 0.4 0.1 0.0 0.0 0.2 0.3 -0.5 -0.5 -0.4 -0.4 -0.1 0.2 0.2 0.0 -1.1 -0.2 0.2
High blood pressure (mother) 0.1 0.1 0.5 -0.2 -0.4 -0.3 0.7 -0.1 0.0 0.1 -0.2 -0.3 -0.4 -0.5 -0.3 0.0 0.3 -0.2 -0.2 0.7 0.1 -0.5
Body mass index (BMI) 0.2 1.0 2.3 -0.8 -1.2 -0.3 1.2 -1.4 -1.4 -1.2 -0.6 -0.7 -0.9 -1.0 0.1 -1.3 -0.5 -1.2 -0.9 -0.2 -0.2 -1.5
Impedance of leg (left) 4.0 19.2 26.0 4.1 4.4 4.8 -4.7 4.6 4.3 4.7 4.3 4.5 3.3 4.0 2.1 4.5 4.8 4.3 4.8 5.1 4.1 4.9
Leg predicted mass (left) 2.4 12.6 20.4 -4.1 -3.4 -3.6 2.9 -3.7 -3.8 -3.2 -3.4 -3.5 -2.4 -4.1 -1.5 -3.6 -4.1 -3.6 -4.0 -4.5 -2.9 -3.8
Trunk fat mass 0.4 1.7 3.4 -1.8 -1.6 -0.8 1.0 -1.7 -1.8 -1.1 -0.9 -0.8 -1.3 -1.9 -0.5 -1.6 -0.8 -1.7 -1.4 -0.7 -0.4 -1.5
Waist circumference 1.0 3.7 7.0 -2.3 -2.3 -1.4 1.6 -2.4 -2.4 -1.2 -1.6 -1.7 -2.0 -2.7 -1.6 -2.2 -1.2 -2.3 -1.9 -1.1 -1.1 -2.3
Number of incorrect matches in round 0.4 0.6 2.0 0.4 0.5 0.8 -0.0 0.6 0.8 0.8 0.5 0.8 0.5 1.4 0.8 0.8 0.9 0.4 0.6 0.9 0.8 1.2
Past tobacco smoking 0.7 1.2 4.1 -1.2 -0.8 -2.0 0.8 -1.0 -0.8 -0.8 -1.5 -0.8 -1.3 -1.1 -0.4 -0.9 -1.3 -0.7 -0.7 -1.4 -1.1 -1.0
Alcohol usually taken with meals 2.6 4.2 7.1 -2.7 -2.1 -2.6 2.0 -2.3 -2.4 -1.7 -2.7 -1.7 -2.0 -1.7 -0.3 -2.3 -1.6 -2.3 -2.0 -1.6 -1.4 -2.2
Nervous feelings 3.9 7.4 13.4 3.0 2.3 3.7 -2.6 2.5 2.3 2.4 2.7 3.0 2.3 2.9 1.8 2.4 3.0 2.5 2.5 3.5 3.0 2.4
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 2.1 0.6 0.3 1.1 -0.2 0.4 0.2 0.5 0.6 0.7 -0.2 0.4 0.0 0.5 0.8 0.3 0.6 1.4 0.4 0.7
Hearing difficulty/problems with background noise 2.0 3.2 6.3 -1.4 -2.0 -1.3 1.4 -2.2 -2.4 -1.3 -1.7 -0.9 -2.4 -1.7 -2.5 -2.2 -1.1 -2.0 -1.5 -0.6 -1.6 -1.9
Hair/balding pattern: Pattern 2 0.3 0.4 1.7 0.9 0.5 1.0 -0.5 0.3 -0.2 0.6 0.4 0.4 0.2 -0.3 0.1 0.4 1.3 0.3 1.3 0.1 0.7 0.3
Had menopause 0.1 0.1 0.6 -0.2 -0.3 0.3 0.0 -0.2 -0.3 -0.5 -0.8 -0.3 -0.4 -0.3 -0.7 -0.2 0.2 -0.3 0.1 -0.5 -0.2 0.0
Had other major operations 2.0 2.5 5.9 -1.2 -1.7 -0.6 1.8 -1.9 -1.9 -1.0 -1.3 -1.1 -1.8 -1.4 -1.6 -2.0 -1.3 -1.5 -1.5 -1.1 -2.4 -1.8
Forced vital capacity (FVC) 1.6 6.3 9.5 -3.1 -2.6 -2.8 1.7 -2.7 -3.0 -2.1 -2.9 -2.6 -2.4 -2.4 -1.8 -2.7 -2.7 -2.7 -2.4 -1.9 -1.8 -2.8
Heel bone mineral density (BMD) T-score, automated (right) 5.2 12.0 18.8 3.5 3.9 3.7 -3.2 3.7 3.0 2.9 3.6 3.5 4.3 2.9 4.2 3.5 2.5 3.8 3.4 2.7 3.8 3.3
Ever unenthusiastic/disinterested for a whole week 3.5 4.2 7.8 1.8 1.7 2.7 -0.9 1.9 2.3 2.0 2.3 1.8 2.2 2.5 2.8 1.7 1.5 1.8 1.8 2.8 1.3 2.3
Qualifications: None of the above 0.3 0.6 3.0 0.4 0.2 0.7 -0.6 0.2 0.3 1.7 1.0 0.5 -0.1 0.2 -1.0 0.0 1.3 0.3 1.1 0.8 0.2 0.7
Financial difficulties in last 2 years 1.1 1.5 3.2 -0.9 -1.1 -0.6 1.7 -1.4 -1.5 -1.4 -0.8 -1.0 -1.1 -1.0 -0.8 -1.3 -1.2 -1.4 -1.1 -1.8 -1.3 -0.9
Mouth/teeth dental problems 0.6 1.0 3.1 0.7 1.1 0.4 -1.6 1.1 0.8 0.6 0.6 0.9 1.7 0.1 0.8 1.5 1.0 0.9 1.0 0.5 1.3 0.5
Heart attack 2.1 2.7 4.5 1.6 1.7 1.9 -1.2 1.6 1.5 1.9 1.9 1.5 1.5 1.2 1.7 1.7 1.7 1.7 1.7 1.3 1.5 2.1
Allergy 2.2 5.1 9.6 2.4 2.3 1.9 -1.4 2.2 2.2 2.5 2.2 2.2 2.2 2.6 2.6 2.1 3.1 2.3 3.0 1.0 1.4 2.3
Pain all over the body in last month 1.3 1.4 3.1 -1.1 -1.3 -1.0 1.1 -1.4 -1.1 -1.2 -0.4 -1.1 -1.7 -0.9 -1.8 -1.5 -1.0 -1.1 -1.0 -0.2 -1.5 -0.8
Diabetes (self-reported) 0.4 0.7 1.4 0.8 0.8 0.6 -0.4 0.7 0.7 0.6 1.2 1.1 0.4 0.6 1.2 1.0 0.9 1.1 0.7 0.7 0.9 0.8
Hayfever/allergic rhinitis (self-reported) 0.6 0.9 3.0 -1.1 -1.0 -0.9 0.4 -0.9 -0.9 -0.4 -0.7 -0.8 -0.6 -1.7 -0.3 -1.0 -1.2 -0.9 -1.0 0.1 0.2 -1.5
Medication: Ramipril 0.9 1.1 3.2 0.7 0.9 0.9 -0.9 1.0 1.1 1.8 1.1 1.3 0.9 0.7 0.1 1.0 1.3 1.1 0.7 1.7 0.9 1.1
Medication: Simvastatin 1.8 2.7 5.2 1.7 1.4 2.1 -0.9 1.4 1.4 1.7 2.1 1.7 1.7 1.9 0.8 1.4 2.3 1.4 1.8 1.4 1.5 1.8
Fluid intelligence score 0.1 0.3 1.5 0.9 0.6 0.1 -0.3 0.5 -0.1 -1.1 0.4 0.4 0.2 0.5 0.3 0.7 -0.4 0.2 -0.1 -1.2 0.3 0.0
Illnesses of siblings 0.4 0.6 1.3 -0.8 -0.7 -0.9 1.0 -0.7 -0.3 -0.8 -1.1 -1.0 -0.4 -0.0 -0.5 -0.6 -1.1 -0.6 -0.9 -1.0 -0.7 -0.6
Neuroticism score 3.0 6.3 17.3 2.4 2.0 4.2 -1.8 2.2 2.0 2.1 3.1 2.3 2.1 2.2 1.8 2.0 2.7 2.0 2.3 3.7 3.0 2.4
Weight 1.0 5.0 9.1 -2.7 -2.3 -1.8 1.7 -2.6 -2.8 -1.7 -2.0 -2.0 -1.8 -3.0 -1.1 -2.5 -2.1 -2.5 -2.4 -2.6 -1.4 -2.6
Impedance of arm (right) 0.1 0.3 1.5 -1.2 -0.7 -0.7 -0.1 -0.3 0.1 0.3 -0.2 -0.5 -0.1 -0.7 -1.1 -0.5 -0.3 -0.5 -0.6 0.8 0.1 0.0
Arm fat percentage (right) 0.7 2.7 4.6 -2.0 -2.1 -1.2 1.9 -2.1 -1.9 -1.5 -1.1 -1.3 -1.6 -1.8 -0.8 -2.1 -1.2 -2.0 -1.8 -0.1 -0.6 -2.0
Trunk fat-free mass 1.4 8.2 20.4 -3.3 -2.5 -2.6 2.3 -2.9 -3.3 -2.0 -2.8 -3.0 -1.9 -3.5 -1.4 -2.8 -3.0 -2.8 -2.8 -4.5 -2.5 -2.9
Hip circumference 1.2 5.1 8.6 -2.6 -2.3 -2.0 1.8 -2.7 -2.8 -1.3 -2.0 -2.2 -1.9 -2.9 -1.5 -2.6 -1.6 -2.5 -2.1 -2.7 -1.7 -2.6
Time employed in main current job 1.0 1.1 1.9 1.0 1.1 0.9 -1.2 1.1 1.0 0.4 0.7 1.3 0.9 1.2 0.7 1.1 1.4 1.2 1.2 1.0 0.9 1.3
Alcohol intake versus 10 years previously 1.4 2.1 4.1 -1.1 -1.6 -1.3 1.5 -1.9 -2.0 -1.1 -1.1 -1.0 -1.9 -1.2 -1.5 -1.9 -0.1 -1.7 -0.5 -1.1 -1.8 -1.4
Father’s age at death 1.2 1.6 3.9 -1.6 -1.4 -2.0 1.4 -1.5 -1.7 -0.2 -1.4 -0.7 -1.1 -1.3 -0.2 -1.3 0.1 -1.4 -1.0 -1.1 -1.0 -1.5
Worrier / anxious feelings 2.0 3.7 9.4 2.0 1.5 3.1 -1.8 1.5 1.2 1.0 2.1 2.1 2.1 1.8 1.6 1.4 2.1 1.4 1.6 2.5 3.0 1.5
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 2.3 -0.6 -1.1 0.4 1.2 -1.0 -1.1 -0.6 -0.4 -1.1 -1.5 -0.9 -1.4 -1.0 -0.9 -1.0 -0.6 -0.3 -0.9 -0.8
Falls in the last year 3.1 4.2 7.4 -1.9 -2.2 -1.4 1.9 -2.3 -2.1 -1.7 -1.6 -1.9 -2.4 -2.2 -2.7 -2.2 -2.1 -2.0 -1.9 -1.7 -2.3 -2.0
Hair/balding pattern: Pattern 3 0.2 0.3 1.6 -0.3 -0.5 -0.5 0.3 -0.4 -0.2 -1.3 -0.5 -0.3 -0.6 -0.2 -0.2 -0.5 -0.9 -0.4 -0.9 -0.6 -0.6 -0.4
Number of live births 0.4 0.5 2.8 -0.5 -0.4 -0.5 0.7 -0.6 -0.6 -0.9 0.2 -0.5 -0.9 -0.1 -0.0 -0.6 -0.8 -0.3 -0.6 -1.7 -1.0 -0.7
Forced expiratory volume in 1-second (FEV1) 1.4 4.7 8.3 -2.6 -2.1 -2.9 1.9 -2.3 -2.5 -2.0 -2.8 -2.2 -1.7 -1.9 -1.0 -2.2 -2.3 -2.2 -2.0 -1.8 -1.4 -2.4
Pulse rate 0.1 0.2 0.8 0.2 0.0 0.1 0.1 0.1 -0.3 -0.8 0.3 -0.7 -0.4 -0.5 -0.5 0.2 -0.7 -0.0 -0.4 -0.9 -0.4 0.1
Happiness 0.5 0.6 2.3 0.8 0.4 1.5 0.1 0.4 0.4 1.3 0.7 0.3 -0.4 0.7 1.3 0.3 0.8 0.4 0.4 1.3 -0.2 0.6
Noisy workplace 0.2 0.3 1.3 -0.1 -0.7 0.1 0.8 -0.6 -0.1 -0.2 0.1 -0.4 -0.7 -0.4 -0.7 -0.7 0.1 -0.6 0.1 -0.2 -1.1 -0.0
Qualifications: A levels/AS levels or equivalent 0.7 1.5 6.9 -0.8 -0.6 -1.8 0.8 -0.7 -0.9 -2.6 -0.9 -1.3 -0.0 -0.4 -0.2 -0.4 -1.8 -0.8 -1.0 -2.2 -1.1 -0.8
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 2.3 -1.1 -1.0 -1.2 1.5 -1.2 -1.3 -0.5 -1.1 -1.2 -0.7 -0.7 -0.2 -1.0 -0.7 -1.2 -1.0 -1.5 -1.0 -1.0
Mouth/teeth dental problems: Dentures 0.1 0.2 0.5 -0.7 -0.4 -0.3 0.6 -0.5 -0.6 0.3 -0.4 -0.3 -0.5 -0.2 -0.4 -0.6 0.0 -0.4 -0.5 -0.7 -0.5 -0.3
Asthma 0.2 0.5 1.1 -0.7 -0.9 0.2 0.1 -0.6 -0.3 -0.7 -0.9 -0.7 -0.7 -0.8 -1.1 -0.5 -0.1 -0.7 -0.6 1.0 0.7 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.8 -0.2 -0.4 0.2 -0.2 -0.5 -0.9 -0.8 -0.2 -0.6 -1.2 -0.8 -1.3 -0.4 -1.0 -0.4 -0.7 -0.3 -0.1 -0.7
Medication: Cholesterol lowering 0.8 1.3 3.2 1.1 1.0 0.9 -0.7 0.9 0.9 1.8 1.6 1.4 0.6 1.3 0.2 1.0 1.6 1.1 0.9 0.9 1.0 1.2
Depression (self-reported) 0.1 0.1 0.5 -0.4 -0.3 0.5 0.4 -0.3 -0.1 0.4 0.1 -0.2 0.7 -0.6 0.3 -0.4 0.3 -0.2 -0.3 0.6 0.3 -0.2
Medication: Lansoprazole 0.5 0.5 2.3 -0.1 0.2 1.3 0.2 0.3 0.4 1.2 0.5 0.0 1.2 -0.2 0.5 0.1 1.1 0.3 0.7 1.5 0.7 0.5
Prospective memory result 0.1 0.1 0.5 -0.4 -0.2 -0.2 0.2 -0.3 -0.4 0.7 -0.6 0.1 -0.1 -0.5 -0.4 -0.3 0.4 -0.4 0.1 -0.4 -0.2 -0.1
Lung cancer (father) 0.2 0.2 1.0 -0.1 -0.1 0.3 0.2 -0.1 -0.1 -0.0 -0.2 -0.6 -0.6 -0.0 -0.3 -0.4 -0.6 -0.0 -0.2 -0.9 -1.0 -0.0
Illnesses of mother 0.6 0.8 1.4 -0.9 -0.7 -1.1 1.1 -0.9 -1.1 -1.2 -0.9 -0.4 -1.0 -0.6 -0.3 -0.8 -1.1 -1.0 -1.0 -0.5 -0.6 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.3 6.8 -2.3 -1.8 -2.5 1.8 -1.9 -2.2 -1.6 -2.6 -1.8 -1.7 -1.5 -0.6 -1.9 -1.8 -1.8 -1.6 -1.4 -1.0 -1.9
Pulse wave Arterial Stiffness index 1.3 1.5 3.7 -1.2 -1.3 -1.3 1.2 -1.2 -0.8 -1.0 -0.8 -1.5 -1.2 -0.9 -1.2 -1.2 -1.6 -0.9 -1.3 -1.9 -1.1 -1.1
Impedance of arm (left) 0.0 0.2 0.6 -0.7 -0.2 -0.5 -0.6 0.1 0.4 0.4 0.1 -0.1 0.1 -0.6 -0.8 -0.1 -0.2 -0.0 -0.3 0.5 0.1 0.3
Arm fat mass (right) 0.5 2.1 3.5 -1.7 -1.8 -1.0 1.3 -1.9 -1.9 -1.4 -1.1 -1.3 -1.3 -1.9 -0.6 -1.8 -1.2 -1.8 -1.6 -0.9 -0.6 -1.8
Trunk predicted mass 1.4 7.9 20.5 -3.2 -2.5 -2.5 2.2 -2.9 -3.3 -2.0 -2.7 -2.9 -1.8 -3.5 -1.4 -2.7 -3.0 -2.8 -2.8 -4.5 -2.5 -2.9
Standing height 1.0 10.0 30.7 -4.2 -2.5 -3.3 1.2 -2.9 -3.3 -1.5 -3.1 -3.0 -1.9 -4.5 -2.5 -2.7 -3.6 -3.0 -3.2 -5.5 -2.8 -2.5
Length of working week for main job 0.2 0.2 0.9 0.4 0.4 0.7 -0.9 0.4 0.5 0.9 -0.1 -0.4 0.5 -0.0 0.1 0.2 -0.2 0.3 0.3 0.6 -0.4 0.2
Exposure to tobacco smoke at home 0.2 0.2 0.7 -0.4 -0.3 -0.2 0.0 -0.4 -0.8 -0.3 -0.2 -0.0 -0.5 -0.7 -0.3 -0.3 0.0 -0.5 -0.2 -0.8 -0.3 -0.3
Breastfed as a baby 0.6 0.8 1.9 -0.6 -0.6 -1.2 0.7 -0.6 -0.8 -1.4 -0.9 -0.6 -0.6 -0.7 -0.5 -0.4 -1.4 -0.6 -1.1 -1.3 -0.8 -0.9
Tense / ‘highly strung’ 0.2 0.4 3.5 -0.2 -0.1 1.0 -0.2 0.2 0.2 0.8 0.7 0.5 0.1 0.2 0.0 0.3 0.8 -0.1 0.1 1.9 1.0 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 2.0 0.3 -0.5 1.0 -0.2 -0.4 -0.1 0.9 0.2 0.4 -0.8 0.6 -0.4 -0.7 0.7 -0.3 0.3 1.4 -0.1 -0.2
Hair/balding pattern: Pattern 4 1.2 3.0 4.6 -1.7 -1.7 -2.0 2.0 -1.7 -1.2 -1.0 -1.8 -2.1 -1.7 -1.6 -2.1 -1.9 -1.6 -1.5 -1.7 -2.1 -1.6 -1.4
Birth weight of first child 1.2 2.2 4.4 -1.6 -1.4 -1.8 1.0 -1.7 -2.1 -1.3 -1.8 -1.0 -1.7 -1.3 -1.2 -1.5 -0.9 -1.6 -1.1 -1.9 -1.3 -1.5
Peak expiratory flow (PEF) 0.3 0.7 3.0 0.4 0.8 0.1 -0.6 0.6 0.4 0.8 -0.1 0.4 1.2 0.4 1.7 0.7 0.8 0.8 1.0 1.0 1.5 0.6
Pulse wave reflection index 1.5 1.8 3.4 -1.4 -1.5 -1.5 1.8 -1.5 -1.2 -0.8 -1.4 -1.2 -1.3 -0.9 -1.1 -1.4 -0.8 -1.3 -1.1 -1.8 -1.3 -1.7
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.6 -0.5 -0.8 -0.1 0.8 -0.7 0.1 0.8 -0.5 -0.9 -1.3 -0.1 -0.2 -1.1 -0.5 -0.5 -0.6 1.3 -0.6 -0.3
Loud music exposure frequency 0.8 0.8 1.9 -1.0 -0.9 -0.6 0.8 -0.8 -0.5 -0.8 -0.3 -1.0 -0.7 -1.4 -1.3 -0.8 -1.2 -0.9 -1.2 -0.8 -1.1 -0.5
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.9 -0.3 0.1 -0.8 0.2 0.0 0.1 -0.7 -0.2 -0.5 0.4 0.1 0.7 0.2 -0.9 0.1 -0.9 -0.7 0.1 -0.1
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.7 0.8 0.7 1.0 -0.6 1.0 1.2 0.5 1.1 0.5 1.0 1.4 0.7 0.9 0.5 0.8 1.0 1.6 1.1 1.6
Blood clot in the leg (DVT) 1.6 2.1 4.7 -1.4 -1.3 -0.7 1.4 -1.3 -1.4 -2.0 -0.8 -1.3 -1.7 -1.2 -1.3 -1.2 -2.2 -1.4 -1.6 -1.8 -1.6 -1.4
Medication: Paracetamol 0.2 0.4 2.3 0.9 0.2 1.5 -0.6 0.5 0.7 -0.0 0.8 -0.1 0.1 -0.1 -0.7 0.4 -0.2 0.6 0.2 1.0 -0.0 0.2
Headache pain in last month 0.4 0.7 2.5 1.1 0.6 1.6 -1.3 0.7 0.8 0.1 0.7 0.4 0.5 1.2 -0.1 0.6 0.3 0.7 0.7 1.3 0.4 0.9
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 2.6 -0.9 -0.6 -0.9 0.4 -0.6 -0.6 -1.6 -0.9 -0.8 -0.3 -0.7 0.1 -0.6 -1.2 -0.7 -0.6 -1.2 -0.8 -0.7
Glaucoma (self-reported) 0.4 0.5 2.6 -0.7 -0.6 0.1 0.2 -0.3 -0.5 -1.6 -0.8 -0.2 -0.5 -0.2 -1.3 -0.1 -0.5 -0.8 -0.5 1.0 0.9 -0.0
Gout (self-reported) 1.7 2.3 3.8 1.8 1.6 1.9 -1.2 1.5 1.3 1.0 1.4 1.4 1.3 1.9 1.9 1.5 1.2 1.6 1.9 0.5 1.2 1.7
Hypothyroidism/myxoedema (self-reported) 4.3 8.5 12.7 3.2 3.0 3.6 -2.8 3.0 2.9 2.8 3.4 2.6 2.9 2.6 2.5 2.8 2.4 3.1 2.8 2.8 2.8 3.1
Medication: Amlodipine 6.3 8.8 10.6 3.0 2.9 2.7 -2.2 3.0 3.1 3.2 2.9 3.0 2.9 3.2 2.9 3.0 3.0 3.1 3.1 3.0 2.7 3.2
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.6 -0.7 -0.3 0.6 0.5 -0.0 0.4 -0.0 -0.3 -0.7 -0.0 -0.8 0.2 -0.2 -0.0 -0.1 -0.2 0.8 0.6 -0.1
Birth weight 0.5 1.0 2.1 1.2 1.1 1.3 -0.5 1.0 0.7 0.7 1.2 1.0 1.2 1.3 1.4 1.1 0.4 0.9 1.0 -0.2 0.1 1.1
Chronic bronchitis/emphysema (mother) 0.5 0.6 2.4 0.9 0.5 1.6 -0.9 0.5 0.3 0.7 0.2 0.3 0.5 0.2 -0.7 0.6 1.5 0.3 1.0 -0.5 0.7 0.7
High blood pressure (siblings) 0.3 0.4 0.9 0.9 0.7 0.9 -0.6 0.7 0.6 0.5 0.7 0.7 0.3 0.4 0.1 0.7 0.7 0.8 0.9 0.3 0.5 0.7
Forced vital capacity (FVC), Best measure 1.6 6.0 9.6 -3.0 -2.5 -2.7 2.0 -2.7 -2.9 -2.0 -3.1 -2.4 -2.7 -2.3 -1.6 -2.6 -2.3 -2.6 -2.2 -1.8 -1.7 -2.7
Body fat percentage 0.1 0.3 1.6 -0.2 -0.3 0.7 0.0 -0.3 -0.4 0.1 0.5 0.7 -0.3 -0.3 0.6 -0.3 0.7 -0.3 0.1 1.2 1.0 -0.3
Leg fat percentage (right) 0.7 2.6 6.5 1.4 1.1 2.4 -1.0 1.0 0.8 1.5 1.9 1.9 0.7 1.2 1.7 1.0 2.4 1.1 1.7 2.5 2.2 1.1
Arm fat-free mass (right) 0.6 3.0 10.2 -1.9 -1.4 -1.3 1.1 -1.8 -2.1 -1.2 -1.6 -1.6 -1.2 -2.2 -0.5 -1.7 -1.9 -1.7 -1.7 -3.2 -1.5 -1.9
Exposure to tobacco smoke outside home 0.2 0.3 1.0 -0.3 -0.6 0.2 -0.5 -0.5 -0.5 0.4 -0.1 -0.3 0.3 -0.4 -1.0 -0.9 -0.4 -0.3 -0.5 1.0 -0.3 -0.4
Comparative body size at age 10 1.1 2.9 7.2 -1.2 -1.6 -2.2 1.7 -1.7 -2.0 -2.7 -1.7 -1.3 -0.8 -0.7 -1.0 -1.7 -2.1 -1.6 -1.9 -1.3 -1.9 -2.0
Number of full brothers 0.2 0.3 1.5 -0.4 -0.6 -0.1 1.2 -0.6 -0.3 -0.3 -0.2 -0.2 -0.6 -0.6 0.2 -0.7 0.2 -0.5 -0.4 -0.5 -0.9 -0.7
Worry too long after embarrassment 0.2 0.4 1.3 0.8 0.6 1.1 -0.9 0.5 0.5 0.1 0.8 0.1 0.9 0.1 0.1 0.5 0.1 0.6 0.3 -0.2 0.8 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 1.1 -0.5 -0.8 0.7 0.2 -0.6 -0.3 0.2 -0.1 -0.7 -0.5 -0.3 -1.1 -0.6 -0.1 -1.0 -0.6 0.5 -0.1 -0.1
Wheeze or whistling in the chest in last year 0.3 0.6 4.1 0.3 -0.4 0.8 -0.5 -0.3 -0.1 0.9 0.3 -0.4 -0.4 -0.7 -1.6 -0.5 0.2 -0.0 -0.0 2.0 0.5 -0.3
Number of children fathered 1.9 2.2 3.4 1.5 1.6 1.3 -1.1 1.6 1.6 0.2 1.1 1.7 1.4 1.8 1.2 1.7 1.2 1.6 1.5 1.4 1.8 1.8
Reason for reducing amount of alcohol drunk: Health precaution 0.8 1.0 2.6 0.9 0.9 1.6 -0.8 1.1 1.0 0.8 0.6 0.8 1.2 1.5 -0.3 1.3 0.8 0.7 0.8 0.9 0.6 1.1
Age at first live birth 0.1 0.2 0.8 -0.2 -0.1 -0.9 0.4 -0.3 -0.0 -0.3 -0.6 -0.2 0.1 0.6 0.3 -0.3 0.2 -0.1 0.2 -0.9 -0.3 0.1
Pulse wave peak to peak time 1.4 1.7 3.3 1.2 1.4 1.4 -1.4 1.3 0.9 1.2 0.9 1.6 1.4 0.9 1.3 1.3 1.6 1.0 1.3 1.8 1.1 1.2
Health satisfaction 1.2 1.5 3.7 -1.1 -1.5 -0.3 1.9 -1.4 -0.9 -0.6 -0.2 -1.1 -1.9 -1.0 -1.2 -1.7 -0.8 -1.2 -1.3 0.6 -1.8 -1.1
Shortness of breath walking on level ground 1.4 1.7 4.6 1.1 1.2 1.6 -1.0 1.4 1.4 1.8 2.2 1.1 1.0 0.9 0.4 1.4 1.1 1.4 1.2 1.4 0.7 1.4
Qualifications: College or University degree 0.3 1.0 4.6 -0.8 -0.6 -1.1 1.0 -0.7 -0.5 -2.1 -1.8 -0.6 0.0 0.5 0.0 -0.6 -1.2 -1.0 -1.1 -1.4 -0.5 -0.0
Eye problems/disorders: None of the above 0.9 1.1 2.8 1.1 0.9 1.3 -0.6 1.1 1.2 1.0 1.5 1.0 1.4 0.8 0.5 0.7 0.6 1.0 0.9 1.7 -0.0 0.9
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.8 0.5 0.5 0.6 -0.3 0.4 0.4 0.9 0.1 0.5 0.0 -0.0 0.0 0.3 0.6 0.5 0.8 0.0 -0.6 0.5
Emphysema/chronic bronchitis 0.4 0.4 1.0 -0.6 -0.6 -0.4 0.7 -0.5 -0.6 -0.1 -0.7 -0.8 -1.0 -0.7 -0.9 -0.5 -0.9 -0.7 -0.9 -0.4 -0.7 -0.4
Medication for pain relief, constipation, heartburn 0.4 0.7 4.8 -1.4 -0.4 -2.2 0.8 -0.5 -0.4 -0.2 -1.3 -0.4 -0.1 0.2 0.8 -0.5 -0.5 -0.8 -0.8 -1.3 -0.4 -0.1
Neck or shoulder pain in last month 1.7 2.5 5.9 -1.5 -1.8 -0.9 1.3 -1.8 -1.8 -0.4 -1.5 -1.8 -2.4 -1.7 -1.7 -1.8 -1.2 -1.6 -1.0 0.1 -1.4 -2.1
Medication: Blood pressure 0.9 1.6 5.5 1.4 1.1 1.4 -0.7 1.0 0.9 2.4 1.2 1.4 0.6 1.4 0.8 0.8 1.7 1.3 1.3 1.6 1.0 1.0
Angina (self-reported) 4.7 6.2 8.7 2.8 2.7 2.1 -2.5 2.4 1.8 2.4 2.9 3.0 2.8 2.7 2.0 2.4 2.0 2.6 2.3 2.3 2.5 2.5
Migraine (self-reported) 1.2 1.5 3.3 1.4 1.2 1.8 -1.1 1.2 1.1 1.1 1.3 1.4 0.9 1.5 0.4 1.0 1.1 1.3 0.9 1.8 0.9 1.1
Medication: Ibuprofen 0.5 0.6 1.8 -0.3 -0.5 -0.2 -0.1 -0.7 -1.2 -0.9 -0.4 -0.5 -1.3 -1.0 -1.4 -0.6 -0.9 -0.7 -0.8 -0.7 0.0 -0.9
Medication: Allopurinol 3.8 5.1 8.4 2.3 2.4 2.5 -1.7 2.3 2.3 1.9 2.5 2.2 1.7 2.8 2.9 2.3 1.8 2.4 2.3 1.4 1.6 2.7
Medication: Omeprazole 0.3 0.3 1.9 0.4 -0.4 1.0 0.6 -0.1 0.5 0.0 0.4 -0.7 -0.0 0.0 -1.1 -0.3 -0.5 0.1 0.2 1.4 0.2 -0.1
Medication: Seretide 50 evohaler 0.4 0.4 1.2 0.6 0.6 0.9 -0.2 0.7 0.6 0.3 0.5 0.2 0.3 0.7 1.1 0.8 0.8 0.5 0.9 0.5 0.7 0.8
Mean time to correctly identify matches 3.0 5.7 9.0 -2.2 -2.5 -2.6 2.7 -2.3 -2.5 -3.0 -2.4 -2.0 -2.5 -2.1 -2.5 -1.9 -2.1 -2.4 -2.4 -2.2 -2.5 -2.2
Heart disease (mother) 8.5 10.3 14.1 3.5 3.6 3.4 -3.4 3.5 3.0 2.9 3.2 2.8 3.7 2.8 3.0 3.4 2.8 3.5 3.5 2.5 2.8 3.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.8 0.4 0.5 0.2 -0.9 0.4 0.1 0.1 0.8 0.2 0.8 -0.5 0.0 0.3 -0.5 0.2 0.1 0.1 0.7 0.5
Whole body fat mass 0.2 1.0 2.4 -1.3 -1.2 -0.4 0.8 -1.3 -1.6 -0.9 -0.6 -0.6 -1.1 -1.5 -0.2 -1.3 -0.5 -1.3 -1.0 -0.4 -0.1 -1.3
Leg fat mass (right) 0.1 0.4 1.3 -0.7 -0.8 0.2 0.5 -0.9 -1.1 -0.4 -0.2 -0.2 -0.8 -0.9 0.1 -0.9 -0.0 -0.8 -0.5 0.2 0.2 -0.9
Arm predicted mass (right) 0.5 2.7 9.4 -1.8 -1.3 -1.2 1.1 -1.7 -2.0 -1.1 -1.6 -1.6 -1.0 -2.2 -0.4 -1.5 -1.8 -1.6 -1.6 -3.1 -1.3 -1.8
Pulse rate, automated reading 0.2 0.5 1.7 0.7 0.6 1.1 -0.2 0.7 0.5 -0.8 0.8 0.7 -0.0 0.4 1.3 0.9 0.2 0.5 0.3 0.3 1.2 0.7
Alcohol intake frequency. 1.9 4.5 6.5 -2.0 -2.4 -1.7 2.3 -2.4 -2.4 -2.2 -1.7 -1.6 -2.6 -2.0 -2.1 -2.5 -1.7 -2.3 -2.1 -1.3 -1.8 -2.5
Comparative height size at age 10 2.6 14.2 26.1 -4.5 -3.4 -4.3 2.4 -3.6 -3.7 -2.4 -3.5 -3.6 -3.3 -4.8 -4.0 -3.4 -3.9 -3.7 -4.0 -5.1 -3.7 -3.2
Number of full sisters 0.1 0.2 0.5 0.3 0.1 0.5 0.7 -0.2 -0.3 0.1 0.6 -0.3 0.1 0.4 0.6 -0.3 -0.3 0.3 -0.1 -0.6 -0.6 -0.1
Suffer from ‘nerves’ 3.7 5.9 13.2 2.6 2.1 3.6 -2.3 2.1 1.8 1.9 2.4 2.6 2.2 2.4 2.0 2.1 2.7 2.2 2.4 3.1 2.6 2.0
Overall health rating 0.3 0.7 2.2 -0.6 -0.9 0.3 0.6 -1.0 -1.0 -0.2 0.6 -0.6 -1.5 -1.3 -1.0 -1.1 -0.6 -0.7 -0.7 0.5 -0.4 -0.7
Chest pain or discomfort 0.3 0.4 2.4 -0.6 -0.6 -0.6 -0.2 -0.5 -0.3 0.9 0.2 -0.7 -0.0 -0.3 -1.6 -0.6 -0.8 -0.3 -0.6 1.2 -0.4 -0.2
Had major operations 0.5 0.6 2.6 0.4 0.7 0.6 -0.0 0.7 0.8 0.4 0.8 0.7 0.9 1.0 1.6 0.8 0.6 0.7 0.6 1.0 0.7 0.9
Age at last live birth 1.6 2.4 6.7 -1.6 -1.4 -1.9 1.5 -1.7 -1.7 -1.7 -1.3 -1.3 -1.1 -0.3 -0.3 -1.8 -1.3 -1.5 -1.2 -2.6 -1.6 -1.6
Family relationship satisfaction 1.1 1.4 5.3 1.1 0.9 1.4 -0.6 0.9 1.0 2.3 1.2 1.1 0.2 1.2 0.7 0.8 1.7 0.9 0.7 2.1 0.7 1.1
Leg pain on walking 0.1 0.1 0.8 0.0 -0.1 0.5 0.3 -0.1 0.1 -0.7 0.2 -0.2 -0.7 -0.1 -0.5 -0.1 -0.5 0.1 -0.0 0.9 -0.2 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 1.5 0.7 0.4 0.7 -0.0 0.2 -0.0 -0.2 0.2 1.1 0.1 0.8 1.2 0.1 0.6 0.3 0.3 0.6 0.2 -0.1
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.9 -0.7 -0.3 -0.5 0.4 -0.5 -0.9 -0.4 -0.6 -0.3 -0.3 -0.7 0.4 -0.6 -0.3 -0.5 -0.3 -0.7 0.0 -0.7
Illness, injury, bereavement, stress in last 2 years 5.9 7.2 11.2 2.7 2.8 2.4 -3.2 2.9 3.4 2.4 1.7 2.2 2.4 2.9 1.7 2.9 2.6 3.0 2.9 2.7 2.7 3.0
Medication: Aspirin 2.8 3.6 5.8 2.2 1.9 2.1 -2.4 1.7 1.4 2.4 2.3 2.0 2.0 1.0 1.3 1.6 2.3 2.0 2.1 1.5 1.7 1.5
Supplements: Vitamin C 2.0 2.4 5.4 -0.9 -1.2 -1.6 0.4 -1.4 -1.5 -1.6 -1.3 -1.5 -1.3 -1.8 -2.3 -1.3 -2.2 -1.2 -1.9 -2.2 -0.9 -1.3
Knee pain experienced in last month 0.7 1.2 3.5 -1.0 -1.2 -0.4 0.9 -1.4 -1.4 -0.8 -0.9 -1.0 -1.9 -1.3 -0.6 -1.4 -0.8 -1.2 -0.5 -0.7 -0.6 -1.2
Hypertension (Self-reported) 0.3 0.7 2.6 0.8 0.6 0.9 -0.9 0.6 0.4 1.6 1.2 1.1 0.4 0.4 0.2 0.4 1.3 0.7 0.9 1.0 0.8 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.2 2.6 6.7 1.7 1.2 2.4 -0.8 1.5 2.0 2.6 1.3 0.7 1.1 1.1 0.7 1.2 2.0 1.6 2.0 2.2 1.0 1.7
Illnesses of father: Heart disease 1.0 1.3 2.2 1.2 1.0 1.1 -1.4 1.2 1.2 1.1 0.7 1.1 1.4 1.1 0.9 1.2 0.9 1.2 1.2 1.5 1.3 1.1
Illnesses of siblings: Diabetes 0.2 0.3 0.9 0.1 0.4 0.6 0.2 0.3 0.2 0.8 0.8 0.6 0.3 0.4 1.0 0.3 0.9 0.2 0.4 0.6 1.0 0.2
Smoking status: Previous 1.2 1.8 4.3 1.3 1.1 2.1 -1.3 1.3 1.1 0.9 1.4 1.1 1.7 1.4 0.6 1.3 1.7 0.9 1.1 1.3 1.7 1.4
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.2 4.7 -1.9 -1.2 -1.4 1.0 -1.4 -1.6 -1.0 -1.2 -1.6 -0.4 -1.8 -1.2 -1.3 -2.2 -1.3 -1.9 -1.8 -1.4 -1.5
Whole body fat-free mass 1.6 9.1 20.6 -3.5 -2.7 -2.8 2.4 -3.1 -3.4 -2.4 -2.9 -3.1 -2.0 -3.7 -1.3 -3.0 -3.4 -3.0 -3.2 -4.5 -2.6 -3.1
Leg fat-free mass (right) 2.6 14.1 22.6 -4.2 -3.6 -3.9 3.1 -3.9 -4.0 -3.5 -3.7 -3.8 -2.6 -4.3 -1.8 -3.8 -4.4 -3.8 -4.2 -4.8 -3.1 -4.0
Arm fat percentage (left) 0.5 2.1 3.5 -1.7 -1.9 -1.0 1.6 -1.8 -1.7 -1.5 -1.0 -1.1 -1.5 -1.6 -0.4 -1.9 -1.1 -1.8 -1.6 -0.1 -0.4 -1.9
Average weekly red wine intake 0.3 0.5 2.1 -0.7 -0.0 -1.5 0.1 -0.3 -1.0 -0.7 -1.1 -0.1 0.7 -0.7 0.6 -0.1 -0.7 -0.3 -0.3 -0.9 0.3 -0.6
Handedness (chirality/laterality): Left-handed 2.3 2.7 6.4 -1.9 -1.6 -1.9 1.6 -1.6 -1.6 -2.1 -1.4 -1.6 -0.8 -1.4 -2.5 -1.4 -1.8 -1.8 -2.2 -0.7 -0.9 -1.5
Mood swings 1.7 3.0 11.4 1.8 1.2 3.4 -0.8 1.5 1.6 1.7 2.3 1.0 1.2 1.6 1.4 1.4 1.4 1.5 1.6 2.7 1.8 1.4
Loneliness, isolation 0.6 0.8 3.7 0.7 0.7 1.9 -0.5 0.7 0.5 0.6 1.8 0.7 0.5 0.6 0.5 0.6 0.8 0.8 0.8 1.2 0.7 0.9
Long-standing illness, disability or infirmity 0.1 0.2 0.9 -0.2 -0.1 0.8 0.1 -0.3 -0.0 0.9 0.9 0.4 -0.2 -0.1 0.0 -0.4 0.3 0.1 -0.1 0.8 0.2 0.4
Ever had bowel cancer screening 0.3 0.4 1.3 -0.4 -0.7 0.2 1.2 -0.5 -0.4 -1.1 -0.4 -0.6 -0.8 -0.4 -0.7 -0.5 -0.5 -0.5 -0.4 0.2 -0.6 -0.4
Diabetes diagnosed by doctor 0.2 0.3 1.2 0.4 0.5 0.3 -0.1 0.4 0.2 0.1 1.1 0.8 -0.1 0.1 0.8 0.8 0.5 0.7 0.2 0.2 1.1 0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.7 0.5 0.2 0.2 -0.0 0.4 0.8 0.4 0.5 0.1 0.1 0.5 0.3 0.3 -0.1 0.4 -0.0 0.7 -0.5 0.5
Friendships satisfaction 0.2 0.3 0.9 -0.1 -0.4 0.4 1.0 -0.4 -0.6 -0.4 0.2 -0.3 -0.8 -0.2 0.2 -0.6 -0.9 -0.5 -1.0 -0.2 -0.2 -0.2
Qualifications: nursing, teaching 1.4 2.2 6.4 -1.1 -1.2 -1.1 1.0 -1.1 -1.2 -2.5 -0.7 -1.9 -1.0 -1.5 -1.2 -1.0 -1.9 -1.1 -1.4 -2.4 -1.9 -1.4
Commuting to job workplace: Walk 0.8 0.9 2.4 1.4 0.9 0.2 -1.4 0.7 0.5 0.1 0.9 1.5 0.4 1.4 1.1 0.7 0.8 1.0 0.9 1.0 0.8 0.4
Eye problems/disorders: Cataract 2.2 2.6 7.6 -1.6 -1.4 -1.8 1.0 -1.7 -2.1 -1.1 -1.8 -1.6 -1.5 -1.8 -1.3 -1.4 -1.3 -1.5 -1.5 -2.8 -0.9 -1.6
Mouth/teeth dental problems: Mouth ulcers 7.1 11.2 18.0 -2.9 -3.6 -3.6 3.5 -3.8 -3.6 -2.9 -3.2 -2.8 -3.7 -2.6 -3.6 -4.2 -2.7 -3.4 -3.2 -3.0 -3.7 -3.2
Medication for cholesterol 3.8 5.8 9.7 -2.5 -2.3 -2.6 2.0 -2.2 -1.7 -2.5 -2.7 -3.0 -1.9 -2.0 -2.0 -2.2 -3.1 -2.2 -3.0 -2.4 -2.6 -2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.5 1.3 -0.3 -0.6 -0.0 0.7 -0.6 -0.5 -0.2 -0.6 -1.1 -0.8 -1.1 -1.1 -0.6 -0.9 -0.6 -0.4 -0.8 -1.1 -0.8
Back pain experienced in last month 1.9 2.7 6.4 1.8 1.5 2.5 -0.9 1.5 1.6 1.7 1.5 1.5 1.2 1.5 1.2 1.3 1.7 1.6 2.0 2.5 1.1 1.8
Mineral and other dietary supplements 0.6 0.7 1.9 0.8 0.9 0.9 -0.7 0.9 0.9 1.1 1.4 0.7 0.5 0.4 0.6 0.8 0.8 1.0 1.0 0.7 1.2 0.7
Breast cancer (self-reported) 0.3 0.4 1.2 -0.6 -0.7 -0.2 1.1 -0.7 -0.8 -0.4 -0.7 -0.3 -1.0 -0.1 0.3 -0.4 -0.0 -0.8 -0.3 0.0 -0.6 -0.9
Asthma (self-reported) 0.3 0.5 0.9 -0.7 -0.9 0.2 0.2 -0.7 -0.5 -1.0 -0.9 -0.6 -0.8 -0.8 -1.0 -0.5 -0.2 -0.7 -0.7 0.9 0.7 -0.8
Osteoporosis (self-reported) 3.7 4.6 7.3 -2.1 -2.3 -1.4 2.0 -2.2 -1.9 -2.1 -2.4 -2.2 -2.7 -1.9 -2.4 -2.3 -2.1 -1.9 -2.1 -1.8 -2.5 -2.0
Osteoarthritis (self-reported) 0.9 1.2 2.6 -1.1 -1.3 -0.8 0.8 -1.3 -1.0 0.1 -0.7 -1.3 -1.4 -1.0 -1.6 -1.6 -0.4 -1.0 -0.6 -1.1 -1.2 -1.2
Medication: Aspirin 2.1 2.8 4.7 2.0 1.7 1.7 -2.2 1.4 1.0 2.0 2.2 1.8 1.8 0.8 1.2 1.4 2.1 1.7 1.9 1.0 1.5 1.3
Medication: Gliclazide 0.2 0.2 1.3 0.2 0.1 0.3 -0.1 0.2 0.0 0.0 0.3 0.9 0.4 -0.0 0.4 0.5 0.3 0.3 0.0 0.5 1.1 0.0
Illnesses of father: None of the above (group 1) 2.8 3.4 4.9 -1.9 -1.8 -1.7 1.8 -1.9 -2.0 -1.8 -1.9 -1.9 -1.7 -1.9 -1.8 -1.8 -1.4 -2.0 -1.5 -2.2 -2.1 -1.8
Smoking status: Current 0.4 0.6 1.5 -0.7 -1.0 -0.3 1.2 -0.9 -0.7 -0.6 -0.1 -0.7 -0.9 -0.7 -1.0 -1.2 -0.6 -0.8 -0.7 0.1 -1.0 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 2.0 -0.8 -0.9 -1.4 1.3 -0.7 -0.2 -0.9 -1.4 -0.6 -0.6 0.2 0.8 -0.7 -0.4 -0.6 -0.5 0.9 0.1 -0.7
Whole body water mass 1.6 8.9 19.5 -3.4 -2.7 -2.8 2.3 -3.1 -3.3 -2.4 -2.8 -3.1 -1.9 -3.6 -1.3 -3.0 -3.4 -3.0 -3.1 -4.4 -2.5 -3.1
Leg predicted mass (right) 2.7 14.6 23.5 -4.3 -3.7 -3.9 3.1 -4.0 -4.0 -3.5 -3.8 -3.9 -2.7 -4.4 -1.8 -3.8 -4.5 -3.8 -4.2 -4.8 -3.1 -4.1
Arm fat mass (left) 0.6 2.6 4.2 -1.9 -1.9 -1.2 1.4 -2.0 -2.0 -1.5 -1.3 -1.4 -1.4 -2.1 -0.6 -2.0 -1.4 -1.9 -1.8 -1.1 -0.8 -2.0
Number of self-reported non-cancer illnesses 0.2 0.4 2.1 0.7 0.1 1.4 -0.8 0.1 -0.2 0.8 0.5 0.5 -0.2 -0.0 -1.1 0.1 0.7 0.1 0.4 1.1 0.5 0.4
Average weekly champagne plus white wine intake 2.8 3.9 7.3 1.6 2.0 1.9 -1.3 2.0 2.2 1.5 2.0 2.1 2.3 2.2 2.7 2.1 1.9 1.8 1.7 1.2 2.1 2.3
Miserableness 1.3 2.2 4.8 1.5 1.4 2.2 -0.9 1.4 1.1 1.7 1.8 1.1 1.1 1.0 1.8 1.2 1.5 1.4 1.8 1.7 1.8 1.3
Guilty feelings 2.3 3.5 11.1 2.1 1.6 3.3 -1.5 1.8 1.8 1.1 2.3 1.3 1.0 1.7 0.6 1.7 1.7 1.9 2.0 2.6 1.9 2.1
Wears glasses or contact lenses 0.4 0.4 1.8 0.4 0.3 0.7 0.6 0.2 0.4 0.8 0.4 0.7 -0.1 1.1 0.9 0.3 1.4 0.3 0.9 -0.4 0.4 0.8
Ever taken oral contraceptive pill 1.6 1.8 3.7 1.0 1.2 1.5 -0.9 1.3 1.5 1.9 1.1 0.8 1.3 1.8 1.4 0.9 1.8 1.1 1.7 1.4 0.6 1.5
Hearing aid user 6.3 7.1 9.7 -2.9 -3.0 -2.4 2.4 -3.0 -3.0 -2.1 -2.5 -2.6 -2.6 -2.9 -3.1 -2.7 -2.5 -3.1 -2.8 -2.2 -2.1 -2.8
Mother’s age at death 0.9 1.1 3.2 -0.9 -1.2 -0.9 1.8 -1.0 -0.7 -0.6 -1.0 -1.0 -1.8 -0.2 -0.9 -0.9 -0.4 -1.3 -0.7 -0.9 -1.7 -0.6
Financial situation satisfaction 0.3 0.4 2.6 1.0 0.5 1.6 -0.3 0.5 0.3 0.2 1.3 0.0 0.3 0.4 0.3 0.4 0.2 0.4 0.3 0.1 -0.1 0.8
Tinnitus: Yes, now most or all of the time 1.1 1.3 3.6 -0.9 -1.3 -1.0 1.0 -1.3 -0.9 -1.1 -1.1 -1.2 -1.9 -0.7 -1.7 -1.2 -0.9 -1.3 -0.9 -0.3 -0.8 -1.2
Commuting to job workplace: Public transport 1.7 2.0 3.7 -1.1 -1.4 -1.6 0.8 -1.3 -0.9 -0.8 -1.4 -1.9 -0.7 -1.9 -1.9 -1.4 -1.7 -1.4 -1.6 -1.0 -1.6 -1.4
Eye problems/disorders: Glaucoma 0.6 0.7 3.7 0.2 0.4 0.6 -1.0 0.6 0.5 -0.3 -0.3 0.7 0.6 0.9 -0.6 0.8 0.5 0.3 0.4 1.6 1.9 0.9
Medication: Blood pressure 1.9 3.6 7.5 2.2 1.6 2.2 -2.0 1.6 1.4 2.0 2.4 2.2 1.1 1.5 0.5 1.6 2.7 1.8 2.4 2.1 1.5 1.5
Pain type(s) experienced in last month: Hip pain 1.3 1.7 4.2 1.3 1.4 2.0 -1.3 1.2 0.9 1.3 1.6 1.3 1.7 0.4 0.9 1.1 1.3 1.2 2.1 0.7 0.8 1.1
Supplements: Fish oil (including cod liver oil) 0.4 0.6 2.0 -0.6 -0.7 -0.7 0.3 -0.7 -0.7 -0.8 -1.0 -0.6 -0.5 -0.5 -1.3 -0.6 -0.5 -0.7 -0.7 -0.5 -1.4 -0.6
High cholesterol (Self-reported) 0.5 0.9 2.0 1.1 0.9 1.4 -1.0 0.8 0.5 1.1 1.4 0.9 0.9 0.6 0.0 0.9 1.3 0.7 1.1 0.3 1.0 1.1
Medication: Bendroflumethiazide 0.3 0.5 3.1 0.6 0.0 0.4 -0.4 0.0 0.0 1.2 0.8 0.1 -0.9 0.1 -0.6 0.0 1.1 0.2 0.7 1.8 -0.2 -0.2
Medication: Paracetamol 0.4 0.6 2.2 1.1 0.4 1.5 -0.8 0.7 1.0 0.4 1.1 0.1 0.4 0.1 -0.8 0.4 0.2 0.9 0.5 1.4 0.2 0.5
Medication: Lisinopril 0.9 1.1 3.7 1.0 1.1 0.8 -0.9 0.9 0.7 1.9 0.7 1.1 0.7 0.9 1.2 1.0 1.4 0.9 1.4 0.3 1.2 0.9
Medication: Atorvastatin 1.0 1.3 3.6 0.9 1.1 0.9 -1.1 0.9 0.8 1.9 1.4 1.6 0.6 1.0 1.0 0.9 1.5 1.1 1.2 0.8 0.9 0.9
Illnesses of father: High blood pressure 2.4 2.9 6.8 1.6 1.3 1.4 -1.4 1.5 1.7 2.2 1.6 1.8 1.7 1.7 1.9 1.5 1.9 1.4 1.6 2.6 1.9 1.3
Alcohol drinker status: Never 0.1 0.1 0.3 -0.5 -0.3 -0.1 0.4 -0.3 -0.4 0.0 -0.4 -0.2 -0.3 -0.5 0.2 -0.3 -0.6 -0.4 -0.6 0.3 -0.0 -0.3
Ever smoked 0.3 0.6 2.9 0.8 0.5 1.7 -0.5 0.6 0.6 0.9 1.2 0.3 0.8 0.5 0.2 0.5 0.9 0.5 0.5 0.8 0.5 0.4
Basal metabolic rate 1.5 8.2 16.7 -3.3 -2.6 -2.6 2.2 -3.0 -3.3 -2.3 -2.6 -2.8 -2.0 -3.6 -1.3 -2.9 -3.1 -2.9 -3.0 -4.1 -2.3 -3.0
Leg fat percentage (left) 0.6 2.3 6.4 1.4 1.1 2.4 -0.9 1.0 0.8 1.2 1.6 1.8 0.7 1.2 1.6 1.0 2.1 1.0 1.6 2.5 2.0 1.1
Arm fat-free mass (left) 0.7 3.3 9.3 -2.1 -1.5 -1.4 1.2 -1.9 -2.3 -1.2 -1.7 -1.8 -1.2 -2.4 -0.8 -1.8 -1.9 -1.8 -1.8 -3.0 -1.5 -2.0
Number of operations (self-reported) 0.7 1.0 3.4 -0.8 -1.1 0.1 1.8 -1.2 -1.3 -0.8 -0.6 -0.5 -1.7 -0.5 0.1 -1.2 -0.3 -1.1 -0.6 -0.2 -1.5 -0.8
Average weekly beer plus cider intake 0.7 1.0 4.1 1.1 1.0 1.0 -0.7 1.0 1.1 2.0 0.8 1.1 0.6 0.7 1.2 0.7 0.8 1.3 0.9 1.1 0.5 0.7
Irritability 0.4 0.7 4.1 0.4 0.4 1.5 -0.3 0.6 0.1 0.6 1.0 0.5 0.4 0.5 0.1 0.5 1.1 0.3 0.6 2.0 1.4 0.5
Risk taking 0.4 0.6 1.8 0.3 0.8 0.4 -0.9 0.7 0.7 1.0 0.4 1.1 0.8 0.7 0.0 0.9 1.4 0.8 0.9 0.1 0.1 0.6
Ever had prostate specific antigen (PSA) test 1.7 2.0 3.6 -1.4 -1.3 -1.7 1.4 -1.3 -1.4 -1.3 -0.9 -1.4 -1.2 -1.5 -1.1 -1.3 -1.2 -1.3 -1.6 -1.9 -1.7 -1.3
Fractured/broken bones in last 5 years 5.3 6.8 16.0 -2.0 -2.6 -2.5 2.2 -2.7 -2.5 -1.9 -2.7 -2.1 -2.6 -2.4 -4.0 -3.0 -3.0 -2.4 -2.9 -2.3 -2.6 -2.5
Age started oral contraceptive pill 1.9 2.3 4.1 -1.2 -1.6 -1.2 1.3 -1.7 -2.0 -1.8 -1.7 -1.6 -1.5 -1.4 -1.7 -1.6 -0.9 -1.7 -1.3 -1.6 -1.4 -1.4
Diastolic blood pressure, automated reading 0.5 1.5 6.2 0.8 0.8 1.3 -0.8 1.1 1.1 0.4 1.5 1.1 1.4 0.5 1.8 1.2 0.6 1.1 0.4 1.7 2.5 0.6
Ever depressed for a whole week 2.1 2.5 5.2 1.8 1.6 2.3 -1.4 1.7 1.6 1.2 1.9 1.2 1.4 2.2 1.8 1.6 0.7 1.6 1.3 1.4 0.9 1.8
Unable to work because of sickness or disability 1.6 2.1 3.5 -1.6 -1.5 -0.9 1.7 -1.5 -1.7 -1.6 -0.9 -1.4 -1.4 -1.5 -1.3 -1.2 -1.6 -1.4 -1.5 -1.3 -1.9 -1.4
Commuting to job workplace: Cycle 3.1 3.7 5.1 2.0 2.2 1.1 -2.0 2.1 2.0 2.2 1.9 1.9 1.9 2.0 1.7 2.3 1.9 2.1 2.1 1.7 1.2 1.9
Myopia 0.5 0.7 2.0 0.7 0.5 1.0 -0.2 0.9 1.2 1.4 1.1 0.4 1.2 0.7 0.3 0.8 0.8 0.8 0.9 0.6 0.6 0.9
Vascular/heart problems diagnosed by doctor 0.3 0.7 2.7 -1.0 -0.7 -0.8 0.9 -0.6 -0.3 -1.6 -1.3 -1.2 -0.5 -0.4 0.0 -0.5 -1.1 -0.7 -0.8 -0.8 -0.8 -0.6
Cholesterol lowering medication 0.1 0.1 0.9 0.5 0.1 1.0 -0.0 0.2 0.0 -0.2 0.7 0.3 -0.0 -0.0 0.1 0.2 0.5 -0.0 0.5 0.1 0.1 0.4
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 3.6 -0.9 -1.5 0.0 1.8 -1.2 -0.4 -0.7 -0.5 -1.9 -1.0 -0.9 -1.9 -1.5 -1.4 -1.0 -0.9 0.6 -0.8 -1.0
Pain experienced in last month 0.1 0.1 0.8 -0.3 -0.0 -0.9 0.0 0.2 0.3 -0.1 -0.4 -0.1 0.2 0.2 0.6 0.3 -0.2 0.0 -0.4 -0.7 0.2 -0.1
Supplements: Calcium 0.1 0.1 0.4 -0.2 -0.4 0.1 0.0 -0.4 -0.6 -0.6 -0.7 0.1 -0.6 -0.0 -0.0 -0.6 -0.1 -0.2 -0.1 0.3 -0.4 -0.5
Basal cell carcinoma (self-reported) 0.4 0.4 1.7 -0.3 -0.1 -0.9 0.2 -0.4 -0.8 -0.7 0.1 -0.6 -1.3 -0.3 -0.6 -0.2 -1.3 -0.3 -0.4 -1.1 -0.5 -0.1
Heart attack/myocardial infarction (self-reported) 2.3 3.0 5.0 1.7 1.9 1.9 -1.5 1.8 1.6 1.9 2.0 1.6 1.6 1.2 1.8 1.8 1.6 1.8 1.8 1.2 1.6 2.2
Deep venous thrombosis (DVT) (self-reported) 1.2 1.6 3.7 -1.1 -1.1 -0.6 1.1 -1.1 -1.1 -1.7 -0.5 -1.1 -1.6 -1.0 -1.5 -1.0 -1.9 -1.1 -1.3 -1.8 -1.5 -1.1
Heart disease (siblings) 1.9 2.3 4.3 1.5 1.6 1.2 -1.9 1.5 1.4 1.6 2.1 1.6 1.8 1.1 1.6 1.6 1.2 1.6 1.4 1.6 1.1 1.3
Alcohol drinker status: Previous 0.2 0.3 1.0 0.7 0.3 1.0 -0.1 0.4 0.4 -0.4 0.7 0.6 0.7 0.7 0.6 0.3 -0.0 0.3 0.2 0.5 0.4 0.1
Pack years of smoking 0.5 0.7 2.0 -0.9 -0.7 -0.4 0.9 -0.8 -1.0 -0.2 -1.1 -0.8 -1.4 -1.1 -1.0 -0.7 0.0 -0.6 -0.4 -1.2 -0.3 -0.4
Impedance of whole body 1.1 5.4 8.8 1.8 2.2 2.3 -2.7 2.5 2.5 2.6 2.4 2.4 1.8 1.8 0.8 2.4 2.4 2.2 2.3 3.0 2.3 2.7
Leg fat mass (left) 0.2 0.6 1.5 -0.8 -0.9 0.1 0.6 -1.0 -1.2 -0.6 -0.4 -0.4 -1.0 -1.1 -0.0 -1.0 -0.4 -1.0 -0.7 -0.0 0.0 -1.1
Arm predicted mass (left) 0.6 2.8 9.0 -1.9 -1.4 -1.2 1.0 -1.8 -2.1 -1.1 -1.5 -1.7 -1.0 -2.2 -0.6 -1.6 -1.8 -1.7 -1.6 -3.0 -1.3 -1.8