Best TWAS P=4.18e-23 · Best GWAS P=1.63e-20 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FEZ2 | 0.16 | 0.24 | lasso | 2 | 0.22 | 1.3e-26 | 8.1 | -8.1 | 5.2e-16 | 0.51 | 0.98 | 0.02 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | AC007401.1 | 0.10 | 0.02 | lasso | 4 | 0.02 | 5.4e-03 | 7.0 | 7.4 | 9.7e-14 | -0.42 | 0.48 | 0.03 | FALSE |
| 3 | GTEx | Artery Tibial | CRIM1 | 0.10 | 0.04 | lasso | 4 | 0.05 | 1.4e-04 | 7.0 | -8.7 | 5.1e-18 | 0.55 | 0.14 | 0.81 | FALSE |
| 4 | GTEx | Artery Tibial | RP11-78I14.1 | 0.10 | 0.08 | enet | 16 | 0.07 | 4.2e-06 | 7.0 | -9.1 | 6.2e-20 | 0.60 | 0.18 | 0.72 | FALSE |
| 5 | GTEx | Brain Cerebellar Hemisphere | CRIM1 | 0.36 | 0.21 | lasso | 5 | 0.16 | 5.4e-05 | 6.6 | 7.1 | 1.3e-12 | -0.42 | 0.34 | 0.08 | FALSE |
| 6 | GTEx | Brain Cerebellar Hemisphere | FEZ2 | 0.41 | 0.30 | lasso | 6 | 0.28 | 8.6e-08 | 6.8 | 6.9 | 5.3e-12 | -0.46 | 0.82 | 0.02 | FALSE |
| 7 | GTEx | Brain Cerebellar Hemisphere | AC007401.1 | 0.40 | 0.26 | lasso | 4 | 0.22 | 2.3e-06 | 6.6 | 6.8 | 1.1e-11 | -0.44 | 0.73 | 0.02 | FALSE |
| 8 | GTEx | Brain Cerebellar Hemisphere | RP11-490M8.1 | 0.37 | 0.18 | lasso | 4 | 0.15 | 1.2e-04 | 6.7 | 7.0 | 3.4e-12 | -0.47 | 0.26 | 0.08 | FALSE |
| 9 | GTEx | Brain Cerebellum | FEZ2 | 0.44 | 0.26 | lasso | 6 | 0.23 | 2.6e-07 | 6.2 | 6.1 | 1.3e-09 | -0.41 | 0.94 | 0.02 | FALSE |
| 10 | GTEx | Brain Cerebellum | AC007401.1 | 0.27 | 0.21 | enet | 5 | 0.20 | 1.5e-06 | 6.6 | 6.8 | 1.1e-11 | -0.44 | 0.62 | 0.06 | FALSE |
| 11 | GTEx | Brain Cerebellum | RP11-490M8.1 | 0.21 | 0.21 | lasso | 4 | 0.20 | 1.4e-06 | 6.6 | 6.7 | 2.2e-11 | -0.45 | 0.58 | 0.06 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | RP11-78I14.1 | 0.14 | 0.06 | enet | 8 | 0.04 | 6.0e-04 | -8.8 | -7.7 | 1.2e-14 | 0.72 | 0.04 | 0.89 | FALSE |
| 13 | GTEx | Spleen | FEZ2 | 0.42 | 0.16 | enet | 25 | 0.17 | 3.9e-05 | 6.6 | 8.2 | 2.2e-16 | -0.44 | 0.29 | 0.19 | FALSE |
| 14 | GTEx | Whole Blood | AC007401.1 | 0.06 | 0.06 | lasso | 5 | 0.05 | 4.6e-05 | 6.8 | 7.1 | 1.7e-12 | -0.46 | 0.78 | 0.01 | FALSE |
| 15 | NTR | Blood | CRIM1 | 0.09 | 0.10 | lasso | 6 | 0.11 | 3.1e-32 | 7.2 | -7.4 | 1.8e-13 | 0.53 | 1.00 | 0.00 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | FEZ2 | 0.41 | 0.55 | lasso | 5 | 0.58 | 3.1e-93 | 7.0 | -7.5 | 5.3e-14 | 0.51 | 1.00 | 0.00 | FALSE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FEZ2 | 0.01 | 0.01 | blup | 85 | 0.01 | 1.0e-03 | 6.9 | -9.0 | 1.9e-19 | 0.60 | 0.30 | 0.13 | FALSE |
| 18 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FEZ2 | 0.06 | 0.05 | lasso | 4 | 0.04 | 3.3e-03 | 7.8 | -7.4 | 9.9e-14 | 0.51 | 0.20 | 0.05 | FALSE |
| 19 | The Cancer Genome Atlas | Colon Adenocarcinoma | FEZ2 | 0.11 | 0.03 | blup | 84 | 0.07 | 6.1e-05 | 8.1 | -5.7 | 1.1e-08 | 0.33 | 0.57 | 0.04 | FALSE |
| 20 | The Cancer Genome Atlas | Esophageal Carcinoma | FEZ2 | 0.11 | 0.01 | blup | 87 | 0.02 | 7.1e-02 | 6.2 | -5.8 | 7.0e-09 | 0.46 | 0.06 | 0.09 | FALSE |
| 21 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FEZ2 | 0.04 | 0.00 | blup | 88 | 0.02 | 6.1e-03 | 6.2 | -5.2 | 2.3e-07 | 0.33 | 0.13 | 0.03 | FALSE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CRIM1 | 0.05 | 0.04 | lasso | 2 | 0.03 | 3.2e-04 | -7.9 | -7.9 | 2.5e-15 | 0.43 | 0.23 | 0.19 | FALSE |
| 23 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FEZ2 | 0.06 | 0.05 | blup | 87 | 0.08 | 1.4e-08 | 7.0 | -7.0 | 1.9e-12 | 0.44 | 1.00 | 0.00 | FALSE |
| 24 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | FEZ2 | 0.18 | 0.21 | lasso | 6 | 0.21 | 5.3e-08 | -9.2 | -9.9 | 4.2e-23 | 0.96 | 0.00 | 1.00 | TRUE |