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chr17:629,675-2,420,934

Best TWAS P=9.22e-19 · Best GWAS P=1.1e-16 conditioned to 0.655

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	GTEx	Thyroid	SMYD4	0.32	0.13	enet	11	0.23	1.5e-17	8.3	-8.8	9.2e-19	-0.91	0.00	1.00	TRUE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	SERPINF2	0.13	0.09	lasso	4	0.10	1.9e-11	-5.6	6.3	2.3e-10	0.06	1.00	0.00	TRUE
7	GTEx	Cells Transformed fibroblasts	CRK	0.19	0.06	lasso	6	0.12	1.6e-09	3.6	5.2	1.9e-07	0.01	0.99	0.00	TRUE
24	The Cancer Genome Atlas	Glioblastoma Multiforme	SMYD4	0.20	0.10	lasso	6	0.20	1.3e-06	7.6	-8.4	4.7e-17	-0.84	0.01	0.94	FALSE
9	GTEx	Colon Sigmoid	SMYD4	0.33	0.24	lasso	7	0.24	5.0e-09	7.8	-8.3	1.0e-16	-0.99	0.01	0.99	FALSE
6	GTEx	Cells Transformed fibroblasts	SERPINF1	0.20	0.11	lasso	3	0.16	5.6e-12	8.2	-8.3	1.4e-16	-0.85	0.01	0.99	FALSE
10	GTEx	Esophagus Muscularis	SMYD4	0.24	0.16	lasso	3	0.18	3.1e-11	7.9	-8.2	3.1e-16	-0.97	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	SMYD4	0.20	0.14	lasso	2	0.16	2.6e-13	8.1	-8.1	8.3e-16	-0.97	0.02	0.98	FALSE
12	GTEx	Nerve Tibial	SMYD4	0.23	0.14	lasso	4	0.17	3.2e-12	7.6	-8.0	1.4e-15	-0.96	0.04	0.96	FALSE
11	GTEx	Lung	SMYD4	0.10	0.09	lasso	3	0.09	1.4e-07	7.8	-7.8	5.2e-15	-0.97	0.02	0.98	FALSE
4	GTEx	Artery Tibial	SMYD4	0.20	0.18	enet	10	0.18	8.2e-14	7.8	-7.7	1.0e-14	-0.98	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SERPINF1	0.34	0.30	enet	24	0.34	2.2e-43	8.1	-7.7	1.1e-14	-0.96	0.00	1.00	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	SMYD4	0.08	0.09	lasso	3	0.07	3.5e-07	7.6	-7.7	1.8e-14	-0.92	0.05	0.95	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	SMYD4	0.08	0.09	lasso	9	0.08	6.3e-09	7.7	-7.7	2.0e-14	-0.97	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	SERPINF1	0.19	0.05	lasso	6	0.02	6.3e-03	8.2	-7.5	6.0e-14	-0.89	0.01	0.96	FALSE
22	YFS	Blood	SMYD4	0.17	0.15	bslmm	436	0.18	1.2e-55	7.9	-7.0	1.9e-12	-0.89	0.04	0.96	FALSE
5	GTEx	Brain Cortex	SMYD4	0.34	0.17	lasso	4	0.23	5.3e-07	7.5	-6.8	8.2e-12	-0.86	0.01	0.96	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	SMYD4	0.12	0.10	lasso	7	0.14	1.2e-15	7.6	-6.8	1.2e-11	-0.86	0.01	0.99	FALSE
19	METSIM	Adipose	SERPINF1	0.06	0.00	bslmm	450	0.02	2.5e-04	8.3	-6.7	2.0e-11	-0.56	0.01	0.97	FALSE
23	YFS	Blood	WDR81	0.17	0.16	enet	22	0.18	1.3e-57	8.2	6.7	2.6e-11	0.85	0.00	1.00	FALSE
16	GTEx	Testis	SMYD4	0.24	0.09	enet	14	0.10	2.9e-05	7.6	-6.7	2.9e-11	-0.78	0.02	0.95	FALSE
14	GTEx	Skin Not Sun Exposed Suprapubic	SMYD4	0.28	0.06	enet	36	0.12	5.8e-07	8.3	-6.6	3.9e-11	-0.64	0.00	0.99	FALSE
8	GTEx	Cells Transformed fibroblasts	SMYD4	0.23	0.18	lasso	4	0.23	5.9e-17	7.8	-6.3	2.2e-10	-0.87	0.03	0.97	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	SERPINF1	0.06	0.03	blup	68	0.05	8.8e-06	8.1	-5.7	1.0e-08	-0.75	0.01	0.98	FALSE
13	GTEx	Pancreas	SERPINF2	0.39	0.29	lasso	1	0.28	1.8e-12	-5.7	5.7	1.2e-08	0.04	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SERPINF2	0.06	0.06	lasso	1	0.06	3.9e-07	-5.7	5.7	1.5e-08	0.04	0.92	0.00	FALSE
21	YFS	Blood	SERPINF2	0.10	0.05	enet	16	0.07	3.1e-22	-3.9	5.4	7.8e-08	0.20	1.00	0.00	FALSE
17	GTEx	Thyroid	WDR81	0.15	0.03	lasso	7	0.03	1.7e-03	2.0	-5.4	7.9e-08	-0.04	0.24	0.26	FALSE
20	NTR	Blood	SERPINF1	0.02	0.01	enet	12	0.02	5.2e-06	8.2	5.2	2.2e-07	0.82	0.01	0.99	FALSE
15	GTEx	Skin Sun Exposed Lower leg	SMYD4	0.17	0.00	lasso	4	0.03	1.3e-03	-5.6	-5.2	2.7e-07	-0.63	0.09	0.85	FALSE