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chr17:5,664,752-8,879,780

Best TWAS P=1.54e-53 · Best GWAS P=2.47e-47 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Adipose Visceral Omentum	CHRNB1	0.29	0.14	lasso	5	0.14	1.0e-07	14.45	15.4	1.5e-53	0.95	0.00	1.00	TRUE
87	The Cancer Genome Atlas	Thyroid Carcinoma	CHRNB1	0.09	0.02	blup	57	0.05	2.6e-05	-3.17	11.1	8.6e-29	0.67	0.11	0.76	TRUE
72	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ALOXE3	0.04	0.00	blup	77	0.01	3.4e-02	-6.59	-8.8	1.7e-18	0.07	0.01	0.60	TRUE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	AMAC1L3	0.04	0.02	blup	54	0.02	3.9e-03	9.11	-7.4	1.2e-13	-0.33	0.28	0.05	TRUE
36	GTEx	Prostate	RP11-104H15.8	0.54	0.01	enet	1	0.06	1.6e-02	-6.95	-7.0	3.7e-12	0.03	0.08	0.06	TRUE
28	GTEx	Lung	CTC1	0.16	0.09	lasso	7	0.12	9.9e-10	6.10	-6.8	7.5e-12	0.00	1.00	0.00	TRUE
39	GTEx	Skin Sun Exposed Lower leg	RP11-849F2.9	0.13	0.00	enet	34	0.02	1.1e-02	-6.79	-6.6	3.2e-11	0.01	0.16	0.06	TRUE
2	CommonMind	Brain Pre-frontal Cortex	EIF5A	0.20	0.12	bslmm	446	0.10	1.2e-12	-3.82	-6.5	8.1e-11	-0.23	1.00	0.00	TRUE
88	The Cancer Genome Atlas	Thyroid Carcinoma	FXR2	0.04	0.03	lasso	1	0.02	1.8e-03	6.46	6.5	1.1e-10	0.32	0.05	0.56	TRUE
13	GTEx	Brain Frontal Cortex BA9	PFAS	0.28	0.04	lasso	5	0.09	2.2e-03	-5.27	-6.4	2.0e-10	0.05	0.11	0.05	TRUE
9	GTEx	Artery Tibial	KDM6B	0.14	0.02	enet	22	0.03	1.4e-03	-2.18	6.2	4.3e-10	0.32	0.18	0.37	TRUE
32	GTEx	Nerve Tibial	RP11-849F2.8	0.22	0.09	enet	30	0.13	3.3e-09	4.98	-6.2	7.5e-10	0.00	0.98	0.00	TRUE
20	GTEx	Esophagus Mucosa	SOX15	0.16	0.03	enet	9	0.07	2.3e-05	8.70	-6.0	2.1e-09	-0.11	0.26	0.04	TRUE
60	ROSMAP	Brain Pre-frontal Cortex	AC113189.5	0.11	0.06	lasso	6	0.06	2.1e-08	4.39	-5.9	3.3e-09	-0.28	1.00	0.00	TRUE
65	The Cancer Genome Atlas	Breast Invasive Carcinoma	C17orf68	0.02	0.01	blup	59	0.01	1.6e-03	4.67	-5.7	1.1e-08	0.00	0.05	0.18	TRUE
52	METSIM	Adipose	PFAS	0.10	0.00	blup	450	0.03	1.7e-05	-6.75	-5.7	1.2e-08	0.01	0.02	0.82	TRUE
46	GTEx	Whole Blood	CTC1	0.13	0.09	lasso	8	0.09	8.6e-09	5.48	-5.2	2.2e-07	0.02	0.99	0.00	TRUE
43	GTEx	Testis	PITPNM3	0.41	0.31	lasso	4	0.34	5.2e-16	4.44	5.2	2.3e-07	0.01	0.02	0.91	TRUE
21	GTEx	Esophagus Mucosa	CHRNB1	0.19	0.11	lasso	2	0.13	7.3e-09	14.45	15.2	7.4e-52	0.95	0.00	1.00	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	CHRNB1	0.17	0.15	lasso	3	0.16	7.4e-09	14.45	14.9	2.0e-50	0.94	0.00	1.00	FALSE
62	YFS	Blood	CHRNB1	0.04	0.02	lasso	5	0.04	8.5e-12	14.42	14.7	3.2e-49	0.92	0.00	1.00	FALSE
42	GTEx	Stomach	CHRNB1	0.28	0.19	lasso	4	0.23	2.0e-11	14.45	14.6	1.7e-48	0.88	0.00	1.00	FALSE
57	ROSMAP	Brain Pre-frontal Cortex	CHRNB1	0.11	0.08	lasso	6	0.08	7.8e-11	14.45	14.6	5.4e-48	0.92	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CHRNB1	0.09	0.06	lasso	2	0.08	9.8e-10	14.45	14.5	9.9e-48	0.93	0.00	1.00	FALSE
16	GTEx	Cells Transformed fibroblasts	CHRNB1	0.28	0.11	enet	25	0.18	2.9e-13	14.45	14.4	3.7e-47	0.74	0.00	1.00	FALSE
38	GTEx	Skin Sun Exposed Lower leg	CHRNB1	0.19	0.12	enet	13	0.12	3.0e-10	12.99	13.8	2.2e-43	0.74	0.46	0.54	FALSE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHRNB1	0.05	0.04	blup	57	0.04	6.1e-05	12.24	13.6	2.1e-42	0.92	0.00	1.00	FALSE
82	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHRNB1	0.18	0.09	enet	10	0.10	4.9e-11	14.45	13.4	4.2e-41	0.79	0.00	1.00	FALSE
4	CommonMind	Brain Pre-frontal Cortex	POLR2A	0.08	0.07	lasso	4	0.07	1.9e-08	12.78	13.3	2.0e-40	0.63	1.00	0.00	FALSE
7	GTEx	Artery Aorta	CHRNB1	0.23	0.10	enet	7	0.13	1.3e-07	-9.29	13.3	3.0e-40	0.75	0.02	0.98	FALSE
24	GTEx	Esophagus Muscularis	ZBTB4	0.13	0.06	lasso	2	0.05	6.3e-04	12.75	13.1	2.8e-39	0.64	0.26	0.31	FALSE
5	GTEx	Adipose Subcutaneous	CHRNB1	0.30	0.22	lasso	8	0.26	1.6e-21	-9.54	13.0	8.9e-39	0.68	1.00	0.00	FALSE
23	GTEx	Esophagus Muscularis	CHRNB1	0.35	0.19	lasso	7	0.28	1.9e-17	-9.29	13.0	9.7e-39	0.65	0.85	0.15	FALSE
66	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHRNB1	0.06	0.06	enet	10	0.06	1.0e-11	14.42	13.0	1.9e-38	0.88	0.00	1.00	FALSE
10	GTEx	Artery Tibial	CHRNB1	0.27	0.20	lasso	5	0.22	8.1e-17	-9.43	13.0	2.0e-38	0.74	0.54	0.46	FALSE
22	GTEx	Esophagus Mucosa	ZBTB4	0.12	0.10	lasso	2	0.08	8.0e-06	12.91	12.9	4.4e-38	0.65	0.89	0.08	FALSE
34	GTEx	Pancreas	TRAPPC1	0.17	0.00	lasso	6	0.01	1.5e-01	12.75	12.5	6.5e-36	0.43	0.06	0.47	FALSE
15	GTEx	Breast Mammary Tissue (Male)	CHRNB1	0.28	-0.01	lasso	6	0.02	9.6e-02	14.45	12.5	1.0e-35	0.86	0.01	0.85	FALSE
27	GTEx	Lung	CHRNB1	0.22	0.05	enet	17	0.14	7.5e-11	-6.03	12.4	2.5e-35	0.61	0.10	0.90	FALSE
18	GTEx	Colon Sigmoid	CHRNB1	0.18	0.06	enet	18	0.11	1.3e-04	-9.43	12.3	1.1e-34	0.66	0.12	0.74	FALSE
71	The Cancer Genome Atlas	Glioblastoma Multiforme	AMAC1L3	0.14	0.12	lasso	3	0.12	1.8e-04	12.13	-12.1	6.5e-34	-0.90	0.01	0.86	FALSE
14	GTEx	Breast Mammary Tissue	CHRNB1	0.23	0.07	enet	19	0.14	1.6e-07	-9.43	11.8	6.6e-32	0.76	0.00	0.99	FALSE
86	The Cancer Genome Atlas	Stomach Adenocarcinoma	CHRNB1	0.06	0.00	blup	57	0.03	4.5e-03	4.62	11.4	4.7e-30	0.87	0.00	0.76	FALSE
31	GTEx	Nerve Tibial	CHRNB1	0.37	0.31	enet	12	0.35	9.7e-26	-9.29	11.3	1.7e-29	0.58	1.00	0.00	FALSE
70	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHRNB1	0.07	0.04	blup	57	0.05	1.6e-03	14.45	11.2	4.0e-29	0.90	0.00	0.88	FALSE
8	GTEx	Artery Coronary	CHRNB1	0.26	0.08	enet	24	0.11	1.3e-04	12.78	10.8	5.6e-27	0.68	0.02	0.92	FALSE
45	GTEx	Thyroid	CHRNB1	0.11	0.03	lasso	8	0.02	7.1e-03	-9.54	10.7	8.9e-27	0.57	0.12	0.47	FALSE
74	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHRNB1	0.06	0.07	lasso	6	0.07	1.8e-08	9.96	10.7	9.5e-27	0.64	0.53	0.46	FALSE
89	The Cancer Genome Atlas	Thyroid Carcinoma	SENP3	0.07	0.04	enet	9	0.03	2.7e-04	6.46	10.6	2.6e-26	0.40	0.41	0.11	FALSE
12	GTEx	Artery Tibial	TNFSF12	0.11	0.06	lasso	2	0.05	1.2e-04	10.50	10.5	8.4e-26	0.31	0.74	0.05	FALSE
79	The Cancer Genome Atlas	Lung Adenocarcinoma	CHRNB1	0.03	0.02	blup	57	0.02	7.8e-04	14.42	10.4	1.6e-25	0.84	0.00	0.99	FALSE
51	METSIM	Adipose	FGF11	0.07	0.00	bslmm	477	0.02	1.5e-04	12.99	-10.4	2.2e-25	-0.52	0.68	0.11	FALSE
49	METSIM	Adipose	CHRNB1	0.22	0.16	bslmm	486	0.20	1.2e-28	-9.43	10.3	9.9e-25	0.62	0.99	0.01	FALSE
80	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TNFSF12-TNFSF13	0.06	0.00	blup	58	0.01	3.4e-02	-0.84	-9.7	2.8e-22	-0.34	0.01	0.06	FALSE
11	GTEx	Artery Tibial	ZBTB4	0.15	0.05	enet	30	0.07	2.9e-06	12.99	9.0	3.2e-19	0.22	0.76	0.05	FALSE
84	The Cancer Genome Atlas	Prostate Adenocarcinoma	TNFSF12-TNFSF13	0.03	0.00	lasso	4	0.01	2.9e-02	-3.00	-8.5	2.4e-17	-0.56	0.01	0.66	FALSE
73	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C17orf68	0.05	0.00	blup	59	0.03	3.3e-04	-6.31	-8.4	6.2e-17	0.01	0.01	0.93	FALSE
64	The Cancer Genome Atlas	Breast Invasive Carcinoma	AURKB	0.02	0.01	blup	49	0.01	2.9e-03	5.48	-8.3	1.1e-16	0.02	0.00	0.62	FALSE
61	YFS	Blood	BCL6B	0.02	0.00	bslmm	470	0.00	2.1e-02	3.37	-7.8	4.3e-15	-0.37	0.16	0.14	FALSE
85	The Cancer Genome Atlas	Soft Tissue Sarcoma	CHRNB1	0.07	0.03	enet	8	0.03	6.9e-03	12.24	7.8	4.8e-15	0.66	0.01	0.38	FALSE
26	GTEx	Lung	CNTROB	0.15	0.06	enet	28	0.07	9.5e-06	-2.96	7.8	5.2e-15	0.20	0.64	0.02	FALSE
40	GTEx	Small Intestine Terminal Ileum	CHRNB1	0.43	-0.01	lasso	9	0.00	2.9e-01	0.25	7.8	8.0e-15	0.26	0.04	0.29	FALSE
90	The Cancer Genome Atlas	Thyroid Carcinoma	SHBG	0.04	0.00	blup	59	0.02	4.4e-03	-0.78	-7.6	4.1e-14	-0.38	0.01	0.75	FALSE
63	YFS	Blood	TMEM107	0.17	0.17	lasso	5	0.19	2.0e-61	-6.63	-7.4	1.6e-13	0.01	1.00	0.00	FALSE
59	ROSMAP	Brain Pre-frontal Cortex	POLR2A	0.05	0.01	bslmm	466	0.02	1.6e-03	12.75	7.3	3.5e-13	0.27	0.52	0.03	FALSE
81	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C17orf68	0.13	0.08	lasso	3	0.10	6.1e-05	5.48	-7.2	5.5e-13	0.01	0.02	0.94	FALSE
19	GTEx	Colon Transverse	CHRNB1	0.19	0.01	enet	18	0.11	6.2e-06	12.87	7.1	1.0e-12	0.45	0.04	0.74	FALSE
50	METSIM	Adipose	CTC1	0.13	0.07	enet	25	0.08	5.8e-12	5.48	-7.1	1.2e-12	0.01	1.00	0.00	FALSE
44	GTEx	Testis	CHRNB1	0.33	0.28	lasso	4	0.30	4.8e-14	4.71	6.9	6.8e-12	0.72	0.96	0.04	FALSE
69	The Cancer Genome Atlas	Breast Invasive Carcinoma	VAMP2	0.04	0.01	blup	47	0.02	2.0e-05	4.98	-6.8	9.3e-12	0.04	0.57	0.10	FALSE
25	GTEx	Heart Left Ventricle	CHRNB1	0.16	0.03	lasso	4	0.05	9.6e-04	-3.17	6.8	1.1e-11	0.39	0.07	0.50	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PFAS	0.10	0.09	lasso	4	0.10	8.9e-13	-5.27	-6.4	1.2e-10	0.01	1.00	0.00	FALSE
33	GTEx	Pancreas	CNTROB	0.14	0.06	lasso	8	0.03	1.5e-02	-2.95	6.4	1.2e-10	0.21	0.33	0.18	FALSE
83	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC25A35	0.09	0.06	enet	12	0.11	3.9e-11	-4.63	-6.4	1.5e-10	-0.01	0.01	0.99	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	FGF11	0.08	0.04	blup	454	0.04	1.2e-05	-3.17	6.3	2.1e-10	0.50	0.97	0.02	FALSE
67	The Cancer Genome Atlas	Breast Invasive Carcinoma	PFAS	0.02	0.01	lasso	3	0.01	9.7e-03	-6.75	-6.2	5.4e-10	0.03	0.00	0.99	FALSE
53	METSIM	Adipose	RP11-849F2.8	0.13	0.11	lasso	3	0.11	3.2e-16	6.23	-6.2	7.2e-10	-0.01	1.00	0.00	FALSE
17	GTEx	Cells Transformed fibroblasts	PFAS	0.13	0.05	lasso	6	0.07	4.1e-06	-6.75	-6.0	1.5e-09	0.00	0.94	0.02	FALSE
47	GTEx	Whole Blood	RP11-849F2.8	0.10	0.06	lasso	8	0.05	1.6e-05	6.23	-6.0	1.5e-09	0.00	0.99	0.00	FALSE
54	NTR	Blood	C17orf68	0.03	0.03	lasso	3	0.03	3.9e-11	6.10	-6.0	2.0e-09	0.00	1.00	0.00	FALSE
41	GTEx	Spleen	CNTROB	0.22	0.04	enet	19	0.03	7.4e-02	-3.02	5.9	3.2e-09	-0.03	0.18	0.05	FALSE
29	GTEx	Lung	RP11-849F2.8	0.12	0.08	lasso	5	0.09	1.2e-07	4.98	-5.7	1.1e-08	0.01	0.99	0.00	FALSE
48	METSIM	Adipose	CHD3	0.06	0.03	blup	509	0.02	6.7e-04	0.97	5.6	2.1e-08	-0.03	0.28	0.02	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC25A35	0.03	0.00	blup	50	0.01	5.6e-04	-2.83	-5.5	2.8e-08	0.02	0.01	0.84	FALSE
78	The Cancer Genome Atlas	Brain Lower Grade Glioma	TNFSF12-TNFSF13	0.07	0.01	enet	17	0.03	4.4e-04	-3.00	-5.5	3.5e-08	-0.29	0.03	0.08	FALSE
35	GTEx	Pancreas	KCNAB3	0.16	0.07	enet	14	0.12	1.0e-05	-3.35	5.4	6.2e-08	0.03	0.86	0.01	FALSE
75	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CHRNB1	0.04	0.03	blup	57	0.02	1.5e-03	-3.04	5.4	6.5e-08	0.62	0.06	0.30	FALSE
30	GTEx	Muscle Skeletal	EIF5A	0.14	0.06	enet	35	0.05	4.2e-06	-3.19	-5.3	9.6e-08	-0.04	0.97	0.00	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	PFAS	0.08	0.02	enet	10	0.03	4.4e-05	-6.79	-5.3	1.1e-07	0.01	0.92	0.01	FALSE
56	ROSMAP	Brain Pre-frontal Cortex	NLGN2	0.25	0.24	lasso	2	0.24	3.0e-30	5.13	-5.2	2.3e-07	-0.34	1.00	0.00	FALSE