TWAS hub - CRK

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2770	0.0670	6.0e-06	0.047	NA	0.050	NA	0.048	1.3e-03	NA	9.0e-04	NA	1.1e-03
2	GTEx	Artery Tibial	0.1878	0.0442	3.3e-07	0.140	NA	0.177	NA	0.182	4.1e-11	NA	7.3e-14	NA	3.5e-14
3	GTEx	Brain Cortex	0.2870	0.0960	6.9e-03	0.013	NA	0.010	NA	0.003	1.3e-01	NA	1.7e-01	NA	2.7e-01
4	GTEx	Cells Transformed fibroblasts	0.1880	0.0460	6.8e-06	0.058	NA	0.119	NA	0.123	3.6e-05	NA	3.5e-09	NA	1.6e-09
5	GTEx	Esophagus Gastroesophageal Junction	0.2360	0.0810	6.6e-03	0.078	NA	0.038	NA	0.057	9.1e-04	NA	1.7e-02	NA	4.2e-03
6	GTEx	Esophagus Muscularis	0.2040	0.0500	2.7e-06	0.197	NA	0.214	NA	0.189	4.2e-12	NA	4.0e-13	NA	1.2e-11
7	GTEx	Nerve Tibial	0.2345	0.0515	7.9e-08	0.124	NA	0.125	NA	0.173	4.6e-09	NA	3.6e-09	NA	2.5e-12
8	GTEx	Stomach	0.1780	0.0620	2.5e-03	0.059	NA	0.056	NA	0.076	8.4e-04	NA	1.1e-03	NA	1.8e-04
9	GTEx	Thyroid	0.1240	0.0370	1.9e-04	0.051	NA	0.098	NA	0.041	8.9e-05	NA	5.9e-08	NA	4.2e-04
10	ROSMAP	Brain Pre-frontal Cortex	0.0829	0.0240	1.4e-05	0.081	0.037	0.062	0.057	0.072	1.3e-10	1.2e-05	1.9e-08	7.4e-08	1.3e-09
11	YFS	Blood	0.0148	0.0067	1.1e-02	0.007	0.002	0.005	0.003	0.001	2.0e-03	4.9e-02	9.3e-03	2.6e-02	1.0e-01
12	TCGA	Pancreatic Adenocarcinoma	0.1260	0.0700	3.1e-03	-0.005	0.050	-0.001	NA	0.001	5.8e-01	3.7e-03	3.4e-01	NA	2.7e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Systolic blood pressure, automated reading	7.9	23.1	34.8	-3.7	-5.8	-5.3	-3.5	-5.1	-5.1	-5.8	-5.9	-4.4	-5.3	-1.3	-4.5
Systolic Blood Pressure	6.7	33.4	54.3	-4.6	-6.8	-6.5	-4.0	-6.3	-5.9	-7.0	-7.4	-5.6	-6.2	-2.9	-4.5
Birth weight of first child	6.7	12.2	19.4	3.9	3.6	1.8	4.1	3.7	3.0	3.7	3.2	4.1	3.1	2.4	4.4
Maternal smoking around birth	6.5	9.3	13.9	-3.0	-3.6	-3.1	-2.7	-3.0	-3.4	-3.3	-3.7	-3.3	-2.9	-1.6	-2.4
Migraine (self-reported)	6.4	8.0	10.6	2.9	2.9	3.0	2.9	2.5	3.2	2.8	3.2	3.2	2.8	1.6	2.4
Medication: Paracetamol	6.4	9.9	13.6	1.6	3.2	3.5	3.4	3.0	3.2	3.4	2.7	3.2	3.4	3.0	3.7
Cardiovascular Disease	6.1	20.2	30.4	-4.2	-4.7	-5.5	-4.0	-3.8	-4.5	-4.5	-5.0	-5.1	-4.4	-3.5	-4.2
Medication: Ramipril	6.1	7.8	9.9	-2.2	-3.1	-3.0	-2.4	-2.7	-3.0	-3.1	-3.1	-2.9	-3.0	-2.5	-2.4
Schizophrenia (2014)	5.7	12.7	19.5	3.6	3.3	3.5	4.4	2.9	4.4	3.3	3.2	4.0	3.4	2.5	3.8
Birth weight	5.7	12.4	17.2	3.5	3.8	3.4	3.7	3.2	4.2	3.8	3.9	3.5	3.9	2.6	2.4
Alcohol drinker status: Never	5.7	6.8	10.1	-1.9	-2.6	-1.5	-3.0	-2.8	-3.0	-2.7	-2.8	-3.2	-2.5	-2.7	-1.9
Illnesses of mother	5.6	6.9	9.8	3.1	2.6	2.3	2.7	2.7	2.8	2.7	2.5	2.9	2.1	2.7	2.2
Medication: Blood pressure	5.6	10.7	14.9	-3.7	-3.1	-3.6	-2.8	-2.8	-3.6	-3.3	-3.0	-3.6	-3.1	-3.9	-2.6
Bipolar Disorder or Schizophrenia	5.5	13.5	22.4	3.1	3.4	3.8	4.1	3.2	4.2	3.6	3.5	3.9	3.5	2.8	4.7
Risk taking	5.5	8.1	13.9	3.4	2.6	3.2	3.7	2.3	2.8	2.7	2.5	2.9	2.9	2.7	2.0
Vascular/heart problems diagnosed by doctor	5.5	15.1	21.2	3.3	3.9	4.6	3.6	3.3	4.2	4.0	4.0	4.2	4.2	4.0	2.9
Severe depression (siblings)	5.2	5.8	7.6	2.4	2.6	2.6	2.5	2.4	2.8	2.6	2.7	1.9	2.8	0.1	2.4
Medication: Bendroflumethiazide	5.2	7.9	13.4	-3.7	-3.1	-2.3	-2.3	-2.5	-3.2	-3.1	-2.9	-3.3	-3.0	-2.1	-1.6
Heart attack	5.1	6.5	9.2	-2.3	-2.9	-2.5	-2.0	-3.0	-2.5	-3.0	-2.8	-2.5	-2.3	-1.8	-2.7
Sensitivity / hurt feelings	5.0	8.5	11.2	-2.9	-2.9	-2.9	-2.9	-2.5	-3.3	-3.1	-2.9	-3.0	-3.2	-2.4	-2.6
Crohns Disease (2012)	4.8	7.8	12.0	-2.9	-3.1	-3.5	-3.1	-2.5	-2.5	-3.0	-3.5	-3.1	-3.1	-0.2	-1.1
Family relationship satisfaction	4.7	5.7	9.7	2.0	2.7	3.1	3.0	2.0	2.3	2.7	2.4	2.5	2.8	0.6	1.4
Irritable Bowel Disease (IBD)	4.6	10.9	16.7	-2.5	-3.6	-3.2	-4.0	-2.9	-3.6	-3.5	-4.0	-4.1	-3.6	-2.1	-1.6
Diverticular disease/diverticulitis (self-reported)	4.6	5.5	9.7	3.0	2.1	2.4	2.4	1.7	2.5	2.3	1.6	2.4	2.3	3.1	2.0
Alcohol usually taken with meals	4.6	7.4	10.6	2.8	2.8	2.7	3.2	2.0	3.0	2.7	3.1	2.6	3.1	1.4	2.6
Medication for cholesterol, blood pressure or diabetes	4.5	7.4	10.1	1.7	2.9	2.8	2.5	2.8	3.0	2.9	3.2	2.9	2.8	2.6	2.4
Medication for pain relief, constipation, heartburn	4.5	7.8	19.2	-1.6	-2.1	-2.5	-3.6	-1.1	-3.0	-2.0	-1.8	-3.1	-3.1	-4.4	-3.4
Age at last live birth	4.4	6.4	11.3	2.0	3.4	2.2	2.5	2.7	2.7	3.0	3.2	2.7	2.7	0.1	1.2
Blood White Count	4.3	31.5	41.6	-5.0	-6.3	-4.4	-5.1	-5.4	-5.8	-6.3	-5.9	-6.3	-5.8	-3.9	-6.5
Leg fat percentage (left)	4.3	15.4	25.1	-3.9	-4.3	-5.0	-3.3	-3.5	-4.3	-4.1	-4.7	-4.3	-3.8	-1.4	-3.2
Schizophrenia (2018)	4.2	8.7	15.2	2.7	2.6	3.4	3.4	2.5	3.4	2.7	2.6	3.1	2.6	2.3	3.9
Leg fat percentage (right)	4.2	15.2	27.0	-3.9	-4.2	-5.2	-3.1	-3.4	-4.3	-4.0	-4.7	-4.3	-3.7	-0.9	-3.3
Friendships satisfaction	4.1	5.0	16.4	2.6	2.2	2.5	4.0	1.6	1.6	2.1	2.0	2.6	2.2	0.5	0.9
HbA1C	4.0	4.5	6.7	1.4	2.5	1.8	2.5	2.1	1.9	2.5	2.5	2.6	2.4	1.2	1.2
Neuroticism	4.0	9.6	17.1	-2.9	-3.3	-3.1	-3.2	-2.9	-4.1	-3.2	-3.5	-2.9	-3.2	-2.3	-1.9
High blood pressure	4.0	11.1	16.5	-2.7	-3.3	-4.1	-3.0	-2.8	-3.6	-3.4	-3.4	-3.7	-3.6	-3.5	-2.4
Crohns Disease (2017)	3.9	8.6	15.5	-2.4	-3.4	-2.9	-3.1	-2.5	-2.9	-3.1	-3.9	-3.9	-3.2	-0.8	-1.8
Hypertension (Self-reported)	3.8	10.5	16.2	-2.5	-3.3	-4.0	-2.9	-2.8	-3.5	-3.4	-3.3	-3.6	-3.5	-3.2	-2.5
Ever had hysterectomy (womb removed)	3.6	4.1	6.4	-2.3	-2.1	-1.8	-2.2	-1.3	-2.5	-2.0	-1.8	-2.2	-2.2	-1.0	-2.1
Lung cancer (father)	3.6	4.2	9.7	2.8	1.7	3.1	1.6	0.1	2.0	1.5	1.5	2.0	2.8	2.0	1.6
Age at first live birth	3.6	6.5	10.7	2.5	3.3	2.4	2.3	2.2	2.9	3.0	2.9	2.7	3.1	1.1	0.6
Supplements: Zinc	3.5	3.8	8.2	1.0	2.1	2.0	2.9	2.8	2.3	2.3	2.0	1.7	1.4	0.0	1.1
Neuroticism score	3.5	7.3	12.4	-2.3	-2.8	-2.9	-3.1	-2.6	-3.5	-2.8	-2.8	-2.3	-2.8	-2.4	-1.6
Serious illness, injury or assault of a close relative in last 2 years	3.5	4.0	6.4	2.4	2.1	1.4	1.6	1.8	1.7	1.9	2.2	2.1	1.8	2.5	2.2
Heart attack/myocardial infarction (self-reported)	3.5	4.5	6.8	-1.8	-2.4	-2.1	-1.6	-2.6	-2.1	-2.5	-2.3	-2.1	-1.9	-1.6	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.4	4.0	7.1	1.1	2.0	1.8	2.7	1.9	2.1	2.2	1.7	1.8	2.3	2.4	1.6
Bipolar Disorder (2018)	3.3	5.2	7.3	1.9	2.3	1.6	2.5	2.1	2.6	2.4	2.4	2.5	2.4	1.6	2.7
Hand grip strength (right)	3.3	8.9	12.8	3.3	3.6	2.6	2.0	3.1	3.2	3.6	3.0	3.0	3.2	2.5	2.5
Ever had prostate specific antigen (PSA) test	3.2	3.7	6.2	1.6	2.2	2.1	1.6	1.3	2.5	2.0	2.4	2.2	2.5	0.4	0.9
Neuroticism (Nagel 2018)	3.0	7.1	11.9	-2.3	-2.8	-2.7	-2.5	-2.9	-3.4	-2.9	-3.1	-2.3	-2.6	-2.3	-1.7
Pack years adult smoking proportion	2.9	4.4	8.1	-1.6	-2.5	-1.2	-1.8	-2.9	-2.4	-2.7	-2.5	-1.8	-2.2	-0.9	-1.6
Worrier / anxious feelings	2.9	5.5	9.3	-2.9	-2.3	-3.0	-2.7	-2.0	-2.5	-2.2	-2.6	-2.1	-2.3	-1.9	-0.8
Medication: Paracetamol	2.9	4.8	8.1	0.1	2.1	2.3	2.4	2.4	2.1	2.2	1.8	2.0	2.1	2.6	2.9
Body fat percentage	2.9	11.4	18.0	-3.7	-3.6	-4.2	-2.5	-2.8	-3.5	-3.4	-4.0	-4.0	-3.1	-1.2	-3.4
Trunk fat percentage	2.8	11.1	17.2	-4.0	-3.5	-4.1	-2.3	-2.4	-3.3	-3.2	-3.9	-4.1	-3.1	-1.2	-3.4
Father’s age at death	2.8	3.8	7.2	1.1	2.4	2.3	1.8	0.9	2.4	2.1	2.2	2.3	2.7	0.0	1.4
Tense / ‘highly strung’	2.8	4.7	7.8	-1.5	-2.6	-2.6	-1.7	-2.8	-2.3	-2.7	-2.3	-1.8	-1.9	-1.5	-1.7
Pack years of smoking	2.8	4.2	6.9	-1.7	-2.3	-1.3	-1.9	-2.6	-2.4	-2.5	-2.4	-1.7	-2.1	-0.9	-1.8
Medication: Simvastatin	2.7	4.0	6.2	-1.8	-2.4	-1.6	-1.8	-2.4	-2.2	-2.4	-2.5	-2.4	-1.9	-1.0	-0.9
Diabetes diagnosed by doctor	2.7	4.4	8.9	-2.0	-2.3	-1.6	-1.9	-2.0	-3.0	-2.1	-2.7	-2.4	-2.1	-0.8	-1.3
Medication for cholesterol	2.7	4.0	5.3	2.2	2.2	2.2	1.7	1.9	2.3	2.2	2.1	2.1	2.1	1.7	1.2
Reaction Time	2.6	5.0	13.3	2.2	2.2	1.4	3.6	2.1	2.4	2.3	1.8	2.6	2.3	1.4	1.4
Average weekly beer plus cider intake	2.6	3.8	5.4	-1.7	-2.3	-2.0	-1.5	-1.8	-2.1	-2.2	-2.1	-1.8	-2.1	-0.7	-2.3
Hayfever/allergic rhinitis (self-reported)	2.5	3.3	7.7	1.2	2.2	2.8	2.4	1.0	1.5	1.8	1.6	1.4	2.2	0.3	1.9
Medication: Cholesterol lowering	2.5	3.8	6.0	-1.1	-2.0	-1.8	-1.8	-2.2	-2.1	-2.0	-2.4	-2.4	-1.8	-2.2	-1.1
Medication: Blood pressure	2.5	4.5	5.9	-1.4	-2.0	-2.3	-1.8	-1.8	-2.4	-2.1	-2.3	-2.4	-2.3	-2.2	-2.0
Worry (Nagel 2018)	2.4	5.0	7.6	-2.2	-2.5	-2.8	-1.8	-2.2	-2.8	-2.5	-2.7	-1.9	-2.4	-1.3	-0.7
Qualifications: None of the above	2.4	5.1	8.0	-2.0	-2.8	-2.7	-2.8	-2.2	-2.0	-2.6	-2.3	-2.1	-2.2	0.2	-1.7
Medication: Lansoprazole	2.3	2.6	4.8	1.1	1.6	1.6	1.1	1.9	1.1	1.8	1.6	1.2	1.5	2.2	2.1
Forced vital capacity (FVC), Best measure	2.3	8.3	19.0	2.2	3.5	1.7	2.2	4.4	3.1	3.7	3.6	2.7	2.4	0.5	2.7
Alcohol intake frequency.	2.3	5.4	9.7	-0.3	-2.1	-2.6	-3.1	-3.1	-2.0	-2.4	-2.3	-2.2	-1.5	-2.7	-2.1
Osteoporosis (self-reported)	2.3	2.9	6.8	0.1	1.9	1.2	2.3	2.6	1.3	2.1	1.6	2.3	1.0	0.7	1.4
Forced vital capacity (FVC)	2.2	8.6	17.1	2.2	3.6	2.0	2.8	4.1	3.1	3.6	3.7	2.9	2.5	0.8	2.3
Qualifications: College or University degree	2.2	6.9	10.5	2.5	3.2	3.1	3.2	2.4	2.6	2.8	2.9	2.7	2.5	0.8	1.9
Height	2.1	40.2	66.6	5.2	6.9	4.7	8.2	6.7	6.6	7.0	5.9	6.0	6.6	5.0	6.7
Nervous feelings	2.1	3.9	6.4	-2.0	-2.3	-2.5	-0.8	-2.0	-2.4	-2.4	-2.3	-1.3	-2.5	-0.9	-0.2
Arm fat percentage (right)	2.1	8.2	11.3	-3.0	-3.1	-2.9	-2.3	-2.6	-3.0	-3.0	-3.3	-3.3	-2.6	-1.0	-3.4
Medication: Ibuprofen	2.1	2.5	8.9	1.6	0.9	1.9	1.6	0.7	1.6	1.0	0.9	1.8	1.3	1.5	3.0
Arm fat percentage (left)	2.1	8.3	11.8	-3.1	-3.1	-3.1	-2.2	-2.5	-3.0	-2.9	-3.4	-3.4	-2.6	-1.2	-3.4
Breast cancer (self-reported)	2.1	2.4	6.7	-1.6	-1.6	-1.2	-1.2	-1.7	-1.6	-1.7	-1.6	-1.3	-1.4	-0.3	-2.6
Number of operations (self-reported)	2.1	3.1	6.2	2.4	1.8	0.9	2.1	1.9	1.2	2.0	1.9	2.5	1.6	0.3	1.5
Diastolic blood pressure, automated reading	2.1	6.6	9.7	-2.4	-3.0	-2.7	-3.1	-2.5	-2.5	-2.8	-2.8	-2.5	-2.7	-0.3	-2.3
Blood Platelet Count	2.0	23.7	32.4	3.9	5.6	4.8	4.3	5.1	5.1	5.5	5.4	5.4	4.7	0.6	5.7
Chronotype (morning person)	2.0	4.6	11.1	-2.1	-2.1	-2.3	-3.3	-1.3	-1.5	-1.9	-1.5	-2.5	-2.1	-1.9	-2.5
Medication: Amlodipine	2.0	2.8	5.0	-2.1	-1.4	-1.6	-0.7	-1.6	-1.3	-1.7	-1.8	-1.6	-1.5	-1.9	-2.2
Worry too long after embarrassment	2.0	3.4	5.9	-2.2	-1.6	-2.4	-1.7	-1.7	-2.2	-1.8	-2.2	-1.9	-1.8	-1.3	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	5.7	1.6	1.7	2.2	2.4	0.7	1.4	1.2	1.5	2.0	1.3	0.7	1.7
Comparative height size at age 10	2.0	11.0	18.4	2.2	3.8	2.4	4.2	4.3	3.4	3.9	3.0	2.8	2.9	2.6	3.6
Irritability	2.0	3.4	10.7	0.0	-1.7	-1.3	-3.3	-1.6	-2.4	-1.7	-1.5	-1.9	-1.6	-1.9	-1.5
Average weekly fortified wine intake	1.9	2.2	4.6	0.3	1.6	2.1	1.5	2.2	1.1	1.9	1.6	1.2	1.2	0.6	1.3
Forced expiratory volume in 1-second (FEV1)	1.9	6.4	16.6	2.2	3.0	1.1	2.3	4.1	2.8	3.1	3.3	2.3	1.6	0.9	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.2	17.5	2.1	3.0	0.9	1.7	4.2	2.8	3.1	3.2	2.0	1.6	0.3	2.4
Chronic bronchitis/emphysema (mother)	1.9	2.2	3.8	-1.2	-1.8	-1.4	-1.9	-1.7	-1.1	-1.8	-1.4	-1.3	-1.2	1.2	-1.6
Illnesses of father: Heart disease	1.9	2.7	6.5	-1.3	-1.6	-2.5	-1.3	-0.7	-1.5	-1.5	-2.1	-1.8	-2.2	-1.0	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.9	4.0	6.5	2.1	1.9	1.7	2.5	1.9	2.0	1.8	1.8	2.1	1.8	1.8	2.1
Illnesses of father: None of the above (group 1)	1.9	2.4	4.5	-0.0	1.8	2.1	1.0	1.9	1.4	1.9	2.1	1.3	1.7	1.2	0.8
Medication: Atorvastatin	1.9	2.3	4.7	-1.1	-1.3	-1.6	-1.9	-1.7	-2.2	-1.6	-1.7	-1.2	-1.6	-0.9	-0.8
Ever smoked	1.9	3.4	7.4	2.0	2.0	1.2	2.3	2.7	1.5	2.3	1.8	1.6	1.3	1.3	1.4
Fractured/broken bones in last 5 years	1.9	2.5	5.9	-1.1	-1.6	-1.6	0.4	-1.8	-1.9	-1.8	-1.7	-1.5	-1.4	-2.4	-0.9
Ulcerative Colitis (UC)	1.8	3.4	6.9	-1.4	-1.7	-1.4	-2.6	-1.7	-2.2	-1.8	-1.9	-2.1	-1.9	-2.0	-0.6
Blood Red Count	1.8	17.8	34.9	-2.5	-4.4	-5.9	-3.8	-3.8	-4.2	-4.3	-4.9	-4.2	-4.0	-3.0	-4.7
Lung FVC	1.8	9.3	19.9	2.8	3.9	2.7	1.0	4.2	3.0	3.8	4.5	3.0	2.5	-0.4	1.9
Qualifications: A levels/AS levels or equivalent	1.8	4.0	6.0	2.4	2.2	2.0	1.8	1.8	2.5	2.1	2.1	1.9	1.8	1.4	1.8
Hair/balding pattern: Pattern 4	1.8	4.5	7.5	-1.2	-2.6	-1.9	-2.7	-1.9	-2.1	-2.3	-2.3	-2.3	-2.3	-1.0	-2.0
Angina (self-reported)	1.8	2.4	5.5	-1.9	-1.6	-1.3	-0.9	-2.4	-1.3	-1.9	-1.9	-1.4	-1.1	-0.4	-1.4
Other serious medical condition/disability diagnosed by doctor	1.7	2.1	5.6	1.3	1.4	1.9	2.4	0.3	1.5	1.2	1.1	1.8	1.9	-0.5	1.0
Medication: Metformin	1.7	2.4	5.2	-0.9	-1.4	-1.1	-2.0	-0.2	-2.2	-1.1	-1.6	-2.0	-2.3	-1.3	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	9.2	1.3	0.9	1.3	1.7	0.8	1.3	1.0	1.0	1.8	1.1	1.0	3.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	5.3	1.6	1.9	1.3	1.9	0.7	1.4	1.4	1.4	2.2	1.8	0.6	2.3
Type 2 Diabetes (T2D) (2018)	1.6	2.9	5.4	-1.4	-1.9	-1.3	-1.8	-1.8	-2.3	-1.8	-2.3	-2.0	-1.7	-0.4	-0.7
Angina	1.6	2.1	4.3	-1.9	-1.5	-1.4	-0.8	-2.1	-1.1	-1.7	-1.6	-1.3	-1.0	-0.8	-1.4
Medication: Levothyroxine sodium	1.6	2.7	4.6	-2.0	-1.2	-1.9	-2.1	-0.7	-1.7	-1.1	-1.1	-1.9	-1.4	-2.1	-1.7
Noisy workplace	1.6	2.0	4.4	2.1	1.2	0.9	1.1	0.8	0.7	1.2	1.0	1.8	1.4	1.9	1.8
Standing height	1.6	15.8	27.1	3.2	4.2	2.9	5.2	4.9	4.4	4.4	3.9	3.4	3.8	2.4	3.9
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	5.4	-0.8	-1.3	-1.8	-0.9	-1.3	-1.4	-1.4	-1.1	-1.1	-1.4	-1.6	-2.3
Leg fat mass (right)	1.6	6.1	11.5	-2.4	-2.5	-3.4	-1.6	-1.9	-2.8	-2.4	-3.1	-3.0	-2.2	-0.7	-2.5
Had major operations	1.6	1.9	3.8	1.4	1.5	0.5	1.4	1.5	1.3	1.5	1.2	1.6	1.2	0.4	1.9
Leg fat mass (left)	1.6	6.4	11.1	-2.4	-2.6	-3.3	-1.8	-2.1	-2.8	-2.4	-3.1	-3.0	-2.2	-1.0	-2.5
Medication: Atenolol	1.5	1.9	4.4	-1.1	-1.2	-0.9	-1.1	-0.7	-1.6	-1.3	-1.0	-1.9	-1.9	-2.1	-1.0
Medication: Omeprazole	1.5	1.8	6.3	0.9	1.0	1.0	2.1	0.5	1.2	0.9	0.7	1.3	1.2	1.4	2.5
Supplements: Vitamin C	1.5	1.8	4.2	0.6	0.8	1.4	1.4	1.6	1.1	1.3	1.3	1.1	1.0	2.0	1.6
Diabetes (mother)	1.4	1.8	3.2	-1.0	-1.6	-1.3	-1.6	-1.1	-1.4	-1.5	-1.4	-1.8	-1.5	-0.3	-1.0
High blood pressure (mother)	1.4	2.0	2.6	-1.4	-1.4	-1.5	-1.5	-1.5	-1.0	-1.5	-1.4	-1.5	-1.1	-1.6	-1.1
Allergy	1.4	3.3	10.4	-1.4	-1.7	-2.3	-3.2	-0.5	-1.4	-1.3	-1.0	-2.1	-1.9	-1.8	-1.5
Loneliness, isolation	1.4	2.0	3.3	-1.5	-1.6	-0.9	-0.8	-1.8	-1.8	-1.7	-1.8	-0.8	-1.4	-1.0	-1.0
Long-standing illness, disability or infirmity	1.4	2.1	6.8	1.1	1.4	0.8	2.6	0.7	1.8	1.4	1.2	1.5	1.9	1.0	0.7
Back pain experienced in last month	1.4	2.1	6.1	-1.3	-1.7	-2.5	-0.8	-1.1	-1.3	-1.6	-1.6	-1.5	-1.5	-0.5	-0.8
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	4.5	1.2	0.9	0.7	2.1	0.7	1.3	0.9	1.0	1.5	1.1	1.2	2.1
Basal cell carcinoma (self-reported)	1.4	1.6	2.5	1.0	1.5	1.1	1.5	1.4	1.2	1.6	1.3	1.4	1.5	0.5	0.9
Hand grip strength (left)	1.3	3.5	5.5	2.3	2.3	1.8	0.7	1.4	2.2	2.2	1.6	1.8	2.2	1.8	1.5
Trunk fat mass	1.3	5.4	10.0	-2.9	-2.3	-3.2	-1.3	-1.3	-2.4	-2.0	-2.8	-3.1	-2.1	-0.6	-2.4
Diabetes (self-reported)	1.3	2.1	4.2	-1.4	-1.4	-0.8	-1.2	-1.5	-2.1	-1.4	-1.9	-1.7	-1.3	-0.9	-1.1
Health satisfaction	1.3	1.7	5.2	0.2	1.2	1.2	2.3	0.9	1.1	1.1	1.1	1.7	1.2	0.9	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	3.6	-1.8	-1.0	-0.8	-0.8	-1.6	-1.2	-1.3	-1.3	-1.2	-1.0	0.4	-1.9
Suffer from ‘nerves’	1.3	2.1	3.7	-1.3	-1.6	-1.7	-1.1	-1.5	-1.9	-1.7	-1.6	-1.2	-1.6	-1.1	-0.0
Mood swings	1.3	2.3	5.6	-0.3	-1.6	-1.2	-1.8	-2.4	-1.3	-1.9	-1.7	-0.8	-1.3	-1.6	-0.9
Fasting Glucose	1.2	1.4	6.0	-1.1	-1.1	-2.4	-1.0	0.0	-0.8	-1.0	-1.2	-0.9	-1.7	-0.2	-0.5
Triglycerides	1.2	1.9	4.7	-0.7	-1.6	-0.9	-1.7	-2.2	-1.2	-1.8	-1.5	-1.6	-0.8	-0.6	-1.2
Heel T-Score	1.2	9.4	17.3	-0.3	-4.1	-3.9	-2.9	-2.8	-3.0	-3.6	-3.4	-4.2	-3.1	0.6	-1.8
Average weekly spirits intake	1.2	1.5	5.3	-1.1	-1.3	-2.3	-1.3	-0.8	-0.9	-1.1	-1.3	-1.3	-1.1	0.4	-1.1
Vitamin and mineral supplements	1.2	1.7	3.6	-1.0	-1.3	-1.3	-1.9	-1.7	-1.3	-1.5	-1.3	-1.2	-1.1	-0.6	-0.7
Supplements: Glucosamine	1.2	1.6	3.1	-0.6	1.3	1.5	0.9	1.8	1.1	1.6	1.5	0.9	1.1	0.9	1.4
Exposure to tobacco smoke outside home	1.2	1.6	4.8	2.0	1.1	2.2	-0.4	0.5	0.7	1.0	1.1	1.5	1.0	1.1	1.4
Mean time to correctly identify matches	1.2	2.3	10.6	1.0	1.3	0.6	3.2	1.5	1.5	1.5	0.7	1.8	1.3	1.4	0.5
Whole body fat mass	1.2	5.2	8.7	-2.5	-2.4	-2.9	-1.3	-1.6	-2.5	-2.1	-2.8	-2.9	-2.0	-0.8	-2.4
Overall health rating	1.2	2.6	6.1	-0.6	-2.1	-1.7	0.2	-2.4	-1.8	-2.2	-2.5	-1.1	-1.4	0.0	-0.1
Osteoarthritis (self-reported)	1.2	1.5	5.3	1.3	0.8	0.6	2.3	0.9	0.3	1.0	0.7	1.1	1.1	1.6	1.6
Multivitamins +/- minerals	1.1	1.4	2.0	0.8	1.4	1.4	1.4	1.2	1.2	1.4	1.2	1.1	1.3	0.1	0.8
Body mass index (BMI)	1.1	4.6	6.9	-2.0	-2.2	-2.3	-2.0	-1.8	-2.6	-2.0	-2.4	-2.6	-1.9	-0.9	-2.3
Had menopause	1.1	1.4	4.3	-1.4	-0.8	-2.1	-0.3	-0.2	-1.3	-0.7	-1.3	-1.1	-1.2	-0.9	-1.6
Trunk fat-free mass	1.1	6.3	10.6	2.4	2.9	2.1	2.8	3.2	2.3	3.1	2.8	2.0	2.4	0.9	2.3
Trunk predicted mass	1.1	6.1	10.2	2.3	2.8	2.1	2.8	3.2	2.3	3.1	2.8	1.9	2.4	0.8	2.2
Heart disease (mother)	1.1	1.3	2.9	-1.1	-0.9	-1.5	-1.3	-0.9	-1.1	-1.0	-0.8	-1.2	-1.0	-1.7	-1.1
Depressed Affect (Nagel 2018)	1.0	2.1	4.5	-1.0	-1.5	-1.0	-1.1	-1.7	-2.1	-1.5	-1.6	-0.9	-1.4	-2.0	-1.1
Respiratory disease	1.0	2.3	9.4	0.6	1.0	0.6	2.6	0.1	1.2	0.8	0.4	1.6	1.5	3.1	1.4
Number of incorrect matches in round	1.0	1.6	3.5	-1.8	-1.5	-1.2	-0.1	-1.9	-0.7	-1.7	-1.7	-0.6	-1.0	0.0	-1.1
Had other major operations	1.0	1.2	3.0	1.2	1.2	0.7	1.2	1.7	0.7	1.3	1.5	0.8	0.5	-1.2	0.5
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	3.8	1.8	1.1	0.7	1.7	0.8	0.8	1.1	1.0	1.9	1.1	0.6	1.8
Arm fat mass (right)	1.0	4.1	6.8	-2.2	-2.1	-2.3	-1.4	-1.6	-2.2	-1.9	-2.4	-2.6	-1.7	-0.9	-2.4
Pulse wave peak to peak time	1.0	1.2	3.0	1.7	1.3	1.4	-0.1	0.5	1.3	1.2	1.1	1.0	1.3	0.2	0.0
Average weekly red wine intake	1.0	1.5	3.9	0.5	1.3	1.3	2.0	0.8	1.5	1.2	1.0	0.9	1.6	1.2	0.9
Ever had bowel cancer screening	1.0	1.2	4.6	1.3	0.9	0.5	2.1	0.9	1.3	0.8	0.8	1.0	0.9	1.0	0.6
Intelligence (Savage-Jansen 2018)	0.9	2.7	6.3	1.7	1.7	1.2	2.5	1.5	1.6	1.5	2.0	1.9	1.3	0.9	1.5
LDL Cholesterol	0.9	1.4	2.2	-0.8	-1.3	-1.3	-1.4	-1.5	-1.1	-1.3	-1.3	-1.2	-1.0	-1.1	0.1
Ulcerative Colitis	0.9	1.3	2.0	-1.2	-1.0	-1.4	-1.4	-0.4	-1.3	-0.7	-1.2	-1.0	-1.2	-1.0	1.4
BMI	0.9	5.1	7.8	-2.4	-2.2	-2.6	-1.6	-1.4	-2.5	-2.0	-2.3	-2.6	-2.4	-1.7	-2.8
Impedance of leg (right)	0.9	4.6	15.8	-2.2	-2.5	-4.0	-0.6	-1.7	-1.8	-2.6	-2.6	-1.4	-2.3	0.6	-0.2
Taking other prescription medications	0.9	1.3	2.7	-1.1	-0.9	-1.3	-0.1	-1.1	-1.1	-1.1	-1.1	-1.2	-0.8	-1.6	-1.6
Hayfever, allergic rhinitis or eczema	0.9	2.0	4.5	2.0	1.4	2.1	2.1	0.4	0.9	0.9	1.1	1.4	1.2	1.0	1.2
Financial difficulties in last 2 years	0.9	1.2	3.9	1.1	0.7	1.2	1.1	0.4	0.5	0.7	0.6	1.4	0.9	1.3	2.0
Asthma	0.9	1.7	4.9	0.3	1.2	1.2	2.2	-0.2	1.5	0.8	0.4	1.7	1.7	1.7	1.1
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.9	1.0	1.5	1.2	0.8	1.0	1.2	1.3	2.0	1.3	1.1	0.5	0.2
Medication: Allopurinol	0.9	1.2	2.5	1.4	1.1	1.6	0.8	0.4	0.9	1.0	1.5	1.2	1.4	0.4	0.7
Number of full sisters	0.9	1.1	2.5	-0.2	0.9	0.8	1.3	0.7	1.2	0.9	1.0	1.1	1.2	1.6	-0.5
Eye problems/disorders: Cataract	0.9	1.0	2.2	-0.9	-1.1	-1.1	-0.4	-0.1	-1.2	-0.9	-0.6	-1.4	-1.5	-0.8	-1.2
Arm fat mass (left)	0.9	3.7	6.3	-2.3	-2.0	-2.3	-1.3	-1.4	-2.2	-1.7	-2.3	-2.5	-1.6	-0.8	-2.2
Myopia	0.9	1.3	2.2	-0.9	-1.5	-1.0	-1.2	-1.0	-1.0	-1.4	-1.4	-1.1	-1.4	0.3	-0.3
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	3.8	-0.6	-0.8	-1.1	-2.0	-0.8	-1.1	-0.7	-0.6	-0.6	-0.7	-0.2	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	4.4	0.3	-1.7	-1.9	-1.2	-0.9	-1.8	-1.5	-1.3	-2.1	-1.5	0.1	-0.1
Stomach or abdominal pain in last month	0.8	1.0	5.6	0.8	0.6	1.0	2.4	-0.1	0.3	0.5	0.5	1.4	1.0	-0.3	1.1
Impedance of leg (left)	0.8	3.9	11.2	-2.2	-2.4	-3.4	-0.5	-1.8	-1.6	-2.5	-2.5	-1.3	-2.1	0.2	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	5.1	-0.8	0.5	0.9	0.7	0.9	1.0	0.7	0.8	0.3	1.0	2.3	-0.1
Knee pain experienced in last month	0.8	1.3	4.7	2.2	1.1	0.8	0.5	1.0	0.7	1.3	1.2	1.2	1.2	0.6	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.7	-0.6	-1.2	-1.3	0.6	-1.0	-0.7	-0.9	-1.3	-0.4	-0.3	-0.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	6.6	1.1	1.6	-0.1	0.3	2.6	0.9	1.7	1.9	0.7	0.4	-1.3	0.2
Illnesses of father: High blood pressure	0.8	0.9	3.8	2.0	0.4	0.4	1.1	-0.4	1.2	0.2	0.3	1.1	1.0	1.4	0.3
Supplements: Calcium	0.8	0.9	3.3	0.5	0.5	1.2	1.2	1.0	0.8	0.7	0.3	0.9	0.3	1.8	-0.6
Prostate Cancer	0.7	1.0	2.0	1.4	0.8	0.9	1.4	-0.1	0.8	0.7	0.5	1.4	1.4	1.2	-0.2
Rheumatoid Arthritis	0.7	1.0	2.1	0.8	1.1	1.4	0.3	0.8	0.8	1.1	1.2	0.9	1.0	-0.2	1.4
Blood Eosinophil Count	0.7	5.6	10.2	-2.4	-2.4	-2.0	-2.2	-1.7	-2.3	-2.3	-2.3	-3.2	-2.4	-2.1	-2.7
Smoking Status	0.7	1.7	5.1	-1.2	-0.8	-1.0	-1.5	0.6	-1.8	-0.5	-0.7	-1.2	-1.8	-2.3	-1.1
Fed-up feelings	0.7	1.3	4.1	-0.6	-0.7	-0.4	-1.4	-1.2	-1.7	-0.7	-0.9	-0.6	-0.6	-2.0	-1.5
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.7	-0.7	-1.1	-0.9	-1.3	-0.7	-1.1	-0.9	-1.0	-0.7	-0.9	-0.5	-0.7
Time employed in main current job	0.7	0.8	7.1	0.3	0.3	0.8	0.2	-0.0	-0.1	0.3	0.2	0.4	0.6	2.7	0.7
Happiness	0.7	0.9	3.4	0.2	1.0	0.9	1.8	1.1	0.0	1.0	0.9	1.1	0.6	0.9	0.0
Depression (self-reported)	0.7	0.9	1.9	1.4	1.1	1.1	0.7	0.2	0.7	0.9	0.6	0.6	1.4	1.0	0.7
Pulse wave Arterial Stiffness index	0.7	0.8	2.5	-1.6	-1.0	-1.2	0.4	-0.2	-1.0	-0.9	-0.9	-0.8	-1.1	0.2	0.3
Eye problems/disorders: None of the above	0.7	0.8	3.5	-0.3	-0.7	-0.1	-1.9	-1.4	-0.3	-0.8	-1.1	-0.9	-0.1	0.9	-0.0
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.0	-0.1	-1.1	-0.7	-0.1	-0.9	-0.4	-1.2	-1.0	-0.8	-1.0	0.8	-1.4
Emphysema/chronic bronchitis	0.7	0.8	2.0	-1.0	-1.1	-0.7	0.7	-0.7	-1.4	-1.0	-0.7	-0.6	-0.7	1.0	-0.9
Pulse rate, automated reading	0.7	2.4	5.9	-2.2	-1.5	-1.7	-2.4	-1.2	-1.7	-1.2	-1.3	-1.4	-1.1	-1.3	-0.6
Mineral and other dietary supplements	0.7	1.0	1.9	-0.6	-0.9	-1.2	-0.9	-1.4	-0.6	-1.1	-1.0	-0.9	-0.6	-1.0	-1.4
Asthma (self-reported)	0.7	1.3	4.4	0.2	1.0	0.9	2.1	-0.4	1.1	0.6	0.2	1.5	1.4	1.6	1.0
Guilty feelings	0.7	1.1	2.2	-0.5	-1.0	-0.8	-1.4	-1.4	-1.5	-1.1	-1.3	-1.0	-0.8	-0.2	-0.8
High cholesterol (Self-reported)	0.7	1.3	2.8	-1.2	-1.4	-0.8	-0.6	-1.6	-1.1	-1.3	-1.7	-1.2	-1.0	-0.6	-0.4
Cholesterol lowering medication	0.7	1.0	2.1	-1.3	-1.3	-0.6	-0.5	-1.5	-1.4	-1.3	-1.1	-0.8	-0.9	0.1	0.3
Hip circumference	0.6	2.8	5.0	-1.7	-1.3	-2.2	-1.0	-0.6	-1.8	-1.1	-1.5	-2.2	-1.4	-2.0	-2.1
Number of full brothers	0.6	0.8	1.6	-0.9	-1.2	-0.4	-0.5	-0.3	-0.4	-1.0	-0.9	-0.4	-1.2	1.3	-1.0
Neck or shoulder pain in last month	0.6	0.9	2.2	-0.3	-1.0	-1.5	0.2	-0.8	-1.0	-1.1	-0.9	-0.7	-1.1	-1.2	0.2
Chest pain or discomfort	0.6	0.9	5.5	0.7	-0.2	0.2	1.3	-1.2	0.2	-0.3	-0.6	0.7	0.7	2.3	0.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.2	-1.0	-1.0	-0.6	-0.7	-0.9	-0.7	-0.9	-0.7	-1.1	-0.7	-0.8	-1.1
Whole body fat-free mass	0.6	3.3	6.4	1.6	2.2	1.6	2.0	2.5	1.7	2.4	2.0	1.0	1.8	0.3	1.4
Qualifications: nursing, teaching	0.6	0.9	2.3	0.6	1.1	0.9	0.5	1.5	0.6	1.2	1.5	0.9	0.3	-1.1	0.5
Commuting to job workplace: Walk	0.6	0.7	1.7	0.1	0.8	0.9	0.4	1.3	1.0	0.9	1.1	0.5	0.4	-0.2	1.2
Whole body water mass	0.6	3.6	6.6	1.7	2.3	1.7	2.1	2.6	1.8	2.5	2.1	1.1	1.9	0.3	1.3
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.2	-0.5	-1.1	-1.3	0.7	-0.8	-0.7	-0.8	-1.0	-0.0	-0.4	1.5	-0.6
Depression (Nagel 2018)	0.5	0.7	2.9	-0.4	-1.2	-0.5	-0.4	-1.7	-0.6	-1.3	-1.2	-0.2	-0.4	-0.2	0.2
Alzheimer’s Disease (in father)	0.5	0.6	2.6	-0.3	-0.5	0.0	-0.4	-0.1	-0.5	-0.6	-0.1	-0.8	-0.9	-1.3	-1.6
Age at First Birth	0.5	0.8	1.8	0.8	1.2	-0.1	0.4	1.1	1.3	1.0	1.3	0.6	0.8	0.4	0.2
Mean Putamen Volume	0.5	0.6	1.6	-0.1	0.5	0.6	1.3	0.3	0.5	0.6	0.1	1.2	0.7	0.8	1.1
Neuroticism (2016)	0.5	0.7	1.7	-0.6	-0.7	-1.3	-0.8	-0.3	-0.9	-0.7	-0.7	-0.4	-1.3	-1.0	-0.3
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.9	-0.5	-1.1	-0.6	-0.5	-1.7	-0.7	-1.3	-1.0	-0.4	-0.4	-0.2	-0.3
Hearing difficulty/problems: Yes	0.5	0.8	1.9	-0.8	-1.1	-0.3	-0.1	-1.0	-1.2	-1.1	-0.8	0.0	-0.9	0.8	-1.4
Diabetes (father)	0.5	0.6	1.3	0.2	-0.5	-1.1	-1.0	-0.4	-1.1	-0.6	-0.9	-0.4	-1.1	-0.7	-0.6
Pain all over the body in last month	0.5	0.5	2.3	0.3	0.3	0.3	1.1	-0.5	0.8	0.1	0.1	0.5	0.9	0.8	1.5
Glaucoma (self-reported)	0.5	0.5	1.7	1.1	0.6	-0.3	0.5	0.8	0.5	0.4	0.3	0.9	-0.5	-1.3	0.9
Comparative body size at age 10	0.5	1.3	4.4	0.3	-0.7	-1.9	-2.1	-0.2	-0.5	-0.6	-0.3	-1.4	-1.1	-1.2	-1.1
Number of children fathered	0.5	0.6	3.2	-0.2	0.0	0.7	0.8	-0.7	1.0	-0.0	-0.4	0.3	1.0	1.8	-0.1
Leg fat-free mass (right)	0.5	2.4	4.5	1.4	2.0	1.9	1.6	2.0	1.6	2.1	1.7	0.5	1.7	-0.2	0.6
Medication: Gliclazide	0.5	0.6	1.6	-0.1	-0.6	-0.6	-1.3	-0.6	-0.3	-0.7	-0.7	-1.1	-0.7	-0.3	-1.1
Eye problems/disorders: Glaucoma	0.5	0.5	3.2	0.3	0.2	-1.0	0.1	1.0	0.1	0.2	0.3	0.3	-0.9	-1.8	0.4
Commuting to job workplace: Cycle	0.5	0.6	2.9	0.9	0.4	0.9	1.7	-0.1	0.4	0.1	0.3	0.7	0.3	0.1	1.3
Impedance of whole body	0.5	2.6	6.0	-2.3	-1.9	-2.5	-0.4	-1.2	-0.9	-2.0	-2.0	-1.3	-1.8	0.1	-0.8
Breast Cancer	0.4	1.1	4.4	1.0	1.2	0.3	0.4	1.3	0.3	1.2	1.3	0.8	0.7	-0.1	2.1
HDL Cholesterol	0.4	0.7	1.5	-0.4	1.0	0.7	0.7	1.0	0.5	1.0	0.8	1.0	0.7	0.3	1.2
Waist Hip Ratio (WHR)	0.4	1.8	6.5	-0.1	0.7	0.4	2.5	1.2	1.3	1.0	0.7	1.2	1.1	2.5	1.0
Lung FEV1/FVC ratio	0.4	1.9	7.5	-0.1	-1.4	-2.7	-0.6	-0.2	-1.5	-1.4	-1.1	-0.9	-2.0	0.8	-1.6
Number of treatments/medications taken	0.4	0.7	4.0	0.3	0.6	0.7	2.0	0.2	0.4	0.6	-0.0	0.6	0.8	0.4	1.4
Relative age of first facial hair	0.4	0.8	2.1	-0.0	-0.8	-1.3	-0.8	-0.7	-0.9	-0.8	-0.4	-0.8	-0.9	-1.4	-1.2
Townsend deprivation index at recruitment	0.4	0.5	1.5	-0.1	-0.9	0.2	0.3	-1.2	-1.1	-1.0	-0.8	-0.2	-0.5	0.7	-0.5
Past tobacco smoking	0.4	0.7	2.8	-0.9	-1.0	-0.1	-0.8	-1.7	-0.5	-1.2	-0.9	-0.5	-0.5	-0.1	-0.4
Falls in the last year	0.4	0.5	1.5	-0.6	-0.8	-0.3	-0.6	-0.6	-1.2	-0.8	-0.9	-1.0	-0.7	0.2	-0.1
Pulse rate	0.4	0.6	1.4	-0.2	1.0	0.2	1.1	0.5	0.3	0.9	1.0	0.9	1.0	-1.2	0.6
Peak expiratory flow (PEF)	0.4	0.8	2.5	-1.4	-0.2	-1.2	0.1	1.6	-0.2	-0.1	-0.0	-1.1	-1.4	0.7	-0.6
Headache pain in last month	0.4	0.6	1.8	-0.1	0.7	0.8	0.9	1.2	0.0	0.9	0.8	0.6	0.5	0.5	1.3
Leg pain on walking	0.4	0.5	1.5	1.2	0.6	0.8	0.9	-0.1	0.3	0.5	0.7	1.1	0.9	0.1	0.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	3.7	0.7	-0.4	-0.9	0.6	0.6	-0.7	-0.2	-0.4	-0.2	-0.9	0.4	1.9
Leg predicted mass (right)	0.4	2.3	4.2	1.4	1.9	1.8	1.5	1.9	1.5	2.0	1.6	0.5	1.7	-0.2	0.6
Mother’s age at death	0.4	0.5	3.9	-0.3	-0.1	0.6	-0.7	-0.5	-0.3	-0.1	-0.8	-0.3	-0.1	-2.0	-0.6
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.4	0.2	-0.7	-0.2	-0.5	-0.7	-1.2	-0.8	-0.3	-0.7	-0.8	-0.7	-0.6
Commuting to job workplace: Public transport	0.4	0.5	2.9	1.7	0.3	0.1	0.6	-0.3	0.7	0.1	0.7	0.8	0.4	-0.8	0.0
Unable to work because of sickness or disability	0.4	0.5	1.8	0.1	-0.7	-1.2	-0.0	-0.6	-1.3	-0.6	-1.1	-0.5	-0.7	-0.2	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.9	-0.4	-0.4	-0.5	-0.5	-0.5	-0.2	-0.5	-0.5	-1.0	-0.5	-1.4	-0.1
Primary Biliary Cirrhosis	0.3	0.4	1.5	0.2	-0.3	-0.8	-0.3	-0.7	-0.7	-0.6	-0.5	-0.2	-0.3	-1.2	-0.5
Allergy or Eczema	0.3	0.8	3.2	1.0	0.3	1.4	1.8	-0.0	-0.1	0.2	0.2	0.8	0.5	1.5	0.2
Medication for hormone replacement therapy	0.3	0.3	1.2	-0.5	-0.4	-0.9	0.3	-0.1	-0.4	-0.3	-0.6	0.2	-0.4	1.1	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	1.9	-0.0	-0.7	-0.1	0.1	-1.4	-0.3	-0.8	-0.8	0.3	0.1	0.1	-0.4
Relative age voice broke	0.3	0.5	1.0	0.9	-0.7	-0.7	-0.6	-0.8	-0.4	-0.7	-0.4	-0.6	-0.3	1.0	-0.8
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.1	1.0	0.1	0.3	0.2	-0.7	0.5	-0.1	0.0	0.7	0.7	1.0	-0.4
Qualifications: CSEs or equivalent	0.3	0.4	1.6	-0.3	0.2	0.2	-0.6	0.6	0.9	0.4	0.7	0.6	0.3	1.2	0.7
Serious illness, injury or assault to yourself	0.3	0.4	1.4	1.0	0.2	-0.4	1.2	-0.4	0.4	-0.1	0.0	0.3	0.4	-1.0	-0.5
Waist circumference	0.3	1.1	3.0	-1.3	-0.9	-1.7	-0.1	-0.1	-1.2	-0.5	-1.2	-1.4	-0.8	0.1	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.4	0.8	-0.8	-1.0	-0.6	0.2	-0.8	-0.5	-0.4	-1.2	-0.7	1.0	0.8
Impedance of arm (right)	0.3	1.2	3.2	-1.8	-1.3	-0.9	-0.1	-1.0	-0.5	-1.4	-1.3	-1.0	-1.1	0.2	-1.2
Number of live births	0.3	0.4	1.7	0.4	-0.8	-0.5	0.2	-0.2	-0.5	-0.8	0.2	-0.1	-1.0	-1.3	0.5
Mouth/teeth dental problems: Dentures	0.3	0.4	2.1	0.4	0.0	0.7	-1.0	0.3	-0.7	0.2	0.1	-0.5	0.0	1.5	-0.8
Length of working week for main job	0.3	0.4	1.1	0.2	0.8	0.1	-0.5	0.9	0.3	1.0	0.3	0.1	0.6	-0.7	0.6
Exposure to tobacco smoke at home	0.3	0.4	1.0	-0.5	-0.7	0.4	-1.0	-0.6	-0.6	-0.8	-0.5	-0.4	-0.6	0.6	-0.4
Pulse wave reflection index	0.3	0.3	1.2	0.8	0.0	0.3	1.0	0.7	0.6	0.1	0.3	0.0	-0.2	1.1	0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.5	-0.5	0.3	-0.1	-1.0	-0.1	0.2	0.3	0.3	-0.5	0.6	-1.6	-1.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.6	-0.6	-0.4	-0.8	0.5	-1.2	0.3	-0.5	-0.7	0.5	0.3	0.4	0.2
High blood pressure (siblings)	0.3	0.5	1.2	-0.3	-0.8	-1.1	-0.6	-0.9	-0.7	-0.9	-0.7	-0.4	-0.7	-0.5	-0.1
Arm fat-free mass (right)	0.3	1.4	4.3	0.9	1.4	0.3	1.5	2.1	0.8	1.7	1.2	0.4	1.0	-0.3	1.1
Medication: Seretide 50 evohaler	0.3	0.4	1.8	-0.4	-0.5	-1.4	-0.6	-0.2	-0.4	-0.5	-0.8	-0.4	-0.8	-0.5	-0.1
Arm predicted mass (right)	0.3	1.4	3.8	1.0	1.4	0.2	1.5	1.9	1.0	1.7	1.2	0.5	1.1	-0.0	1.0
Medication: Aspirin	0.3	0.4	1.0	0.3	0.1	0.3	0.8	-0.9	0.4	-0.2	-0.2	0.7	0.6	1.0	1.0
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.7	0.2	-0.8	-0.5	-0.8	-0.7	-0.2	-0.8	-0.8	-0.5	-0.8	-0.2	0.6
Medication: Aspirin	0.3	0.4	1.5	0.4	0.1	0.3	0.8	-0.7	0.4	-0.1	-0.1	0.7	0.6	1.1	1.2
Number of self-reported non-cancer illnesses	0.3	0.6	2.3	0.5	-0.2	-0.7	1.5	-1.1	-0.3	-0.4	-1.1	0.0	0.4	-0.4	0.9
Hearing aid user	0.3	0.3	1.3	0.7	-0.3	-0.6	-0.6	0.2	-0.2	-0.1	-0.3	-0.3	-0.5	-0.7	-1.1
Financial situation satisfaction	0.3	0.4	2.1	-0.4	-0.2	-0.2	0.8	-0.2	-0.8	-0.3	-0.5	-0.2	-0.3	-1.4	-0.9
Basal metabolic rate	0.3	1.8	4.2	1.1	1.6	1.0	1.6	2.0	1.2	1.9	1.4	0.6	1.4	0.1	1.0
Arm fat-free mass (left)	0.3	1.6	3.7	1.2	1.5	0.7	1.5	1.9	1.0	1.7	1.4	0.6	1.2	-0.1	1.1
Age started oral contraceptive pill	0.3	0.4	0.8	0.6	0.7	0.5	0.7	0.9	0.4	0.6	0.6	0.4	0.2	0.9	-0.6
Heart disease (siblings)	0.3	0.4	1.5	1.2	-0.2	-0.5	-1.2	-0.5	-0.5	-0.4	-0.3	-0.1	-0.4	-0.3	0.2
Alzheimer’s Disease (in mother)	0.2	0.2	1.5	-1.2	0.2	0.1	0.3	0.2	0.1	0.4	0.1	-0.0	0.6	0.1	-0.6
Alzheimer’s Disease (including proxy)	0.2	0.2	2.0	-0.7	-0.3	0.3	-0.0	0.1	-0.1	-0.1	0.2	-0.3	-0.0	-0.3	-1.4
Ovarian Cancer	0.2	0.2	0.9	-0.7	-0.2	-0.9	-0.0	-0.7	0.2	-0.5	-0.2	-0.1	-0.2	0.1	-0.4
Coronary Artery Disease (CAD)	0.2	0.2	2.9	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.7
Lupus	0.2	0.4	1.4	-1.0	-0.6	-1.2	-0.6	-0.0	-0.2	-0.4	-0.3	-0.6	-0.7	-0.2	0.1
Hypothyroidism (self reported)	0.2	0.5	2.6	0.6	0.6	-0.1	-0.6	-0.2	0.2	0.4	0.7	0.1	1.0	-0.9	-1.6
Tanning	0.2	2.5	3.8	-1.4	-1.9	-0.7	-1.8	-1.4	-1.6	-1.8	-2.0	-1.9	-1.9	-0.1	-1.2
Leg fat-free mass (left)	0.2	1.2	2.9	0.9	1.4	1.0	1.2	1.7	1.1	1.6	1.1	0.1	1.2	-0.1	0.2
Chronic bronchitis/emphysema (father)	0.2	0.3	0.7	-0.1	-0.8	-0.5	-0.4	-0.8	-0.7	-0.5	-0.8	-0.4	-0.2	0.2	0.3
Leg predicted mass (left)	0.2	1.1	2.5	0.8	1.3	1.0	1.2	1.6	1.0	1.5	1.0	0.0	1.1	-0.1	0.2
Hearing difficulty/problems with background noise	0.2	0.3	1.8	0.3	0.3	0.9	1.3	-0.0	0.3	0.1	0.3	0.5	0.2	-0.3	-0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.7	-0.8	0.4	-0.2	0.6	0.7	0.3	0.4	0.5	0.2	0.1	-0.0	0.2
Mouth/teeth dental problems	0.2	0.3	1.2	-1.1	-0.2	0.3	-0.8	-0.4	0.6	-0.1	-0.1	-0.0	0.3	-0.4	0.7
Fluid intelligence score	0.2	0.3	1.0	0.2	-0.5	-1.0	-0.0	-0.4	-0.5	-0.4	-0.6	-0.6	-0.7	-0.3	-0.7
Hair/balding pattern: Pattern 3	0.2	0.3	1.6	1.3	0.2	0.9	-0.1	0.1	0.1	0.3	0.0	0.2	0.1	0.9	0.0
Prospective memory result	0.2	0.3	1.9	-0.0	-0.2	-0.3	-0.6	-0.4	-0.2	-0.3	0.2	-0.2	0.0	-0.9	-1.4
Impedance of arm (left)	0.2	0.7	2.4	-1.5	-0.9	-1.0	0.2	-0.5	-0.1	-1.0	-1.1	-0.8	-0.8	0.4	-0.9
Ever highly irritable/argumentative for 2 days	0.2	0.2	1.2	0.1	-0.3	0.2	0.3	-0.6	-1.1	-0.4	-0.4	0.2	-0.2	0.5	0.2
Loud music exposure frequency	0.2	0.2	1.1	-0.0	0.1	-0.4	1.1	-0.4	-0.5	-0.1	-0.4	0.1	0.2	0.2	0.8
Wheeze or whistling in the chest in last year	0.2	0.4	1.0	-0.8	-0.3	-0.6	0.6	-0.9	-1.0	-0.5	-0.8	-0.1	-0.1	0.3	-0.3
Shortness of breath walking on level ground	0.2	0.3	1.0	-0.2	-0.3	0.6	0.0	-0.7	-0.7	-0.5	-0.3	-0.1	-0.1	0.4	-1.0
Illnesses of siblings: Diabetes	0.2	0.3	0.7	0.1	0.2	0.7	0.5	0.8	0.3	0.4	0.8	0.5	0.0	-0.0	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.9	-0.1	-0.2	-0.9	-0.1	0.2	0.6	0.1	-0.1	-0.3	0.2	0.5	0.7
Miserableness	0.2	0.4	1.3	-0.2	-0.5	-0.3	-0.3	-1.1	-0.9	-0.6	-0.7	-0.2	-0.2	-0.7	-0.4
Wears glasses or contact lenses	0.2	0.3	1.4	0.5	0.2	-1.2	-0.4	0.5	-0.2	0.2	-0.0	-0.5	-0.5	-0.8	-0.0
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.7	-0.2	0.3	0.7	0.2	0.7	-0.2	0.5	0.1	0.2	-0.0	0.6	0.8
Ever depressed for a whole week	0.2	0.3	1.7	0.4	0.3	0.4	1.3	0.4	0.2	0.2	0.6	0.4	0.1	0.8	0.0
Arm predicted mass (left)	0.2	1.0	3.0	0.8	1.2	0.2	1.3	1.7	0.6	1.4	1.1	0.3	0.9	-0.2	0.8
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.9	0.6	0.4	-0.1	0.9	0.4	0.3	0.4	0.4	0.3	0.2	0.4	-0.2
Type 2 Diabetes (T2D) (2012)	0.1	0.2	2.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.4
Hair Pigment	0.1	1.7	7.1	1.8	1.5	0.8	-0.1	0.5	0.4	1.2	1.1	1.7	1.1	-0.0	2.7
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.8	0.2	0.0	-0.3	0.9	0.1	-0.5	0.1	-0.5	0.7	-0.0	0.2	0.3
Medication: Co-codamol	0.1	0.1	0.5	-0.1	0.2	0.3	-0.1	-0.2	0.1	0.1	-0.2	-0.3	0.5	0.7	-0.1
Current tobacco smoking	0.1	0.2	0.8	-0.4	0.1	0.4	-0.4	0.5	-0.9	0.0	-0.1	-0.1	-0.6	-0.6	-0.8
Age when periods started (menarche)	0.1	0.1	0.4	0.5	0.2	0.5	0.3	0.2	0.1	0.2	0.2	0.5	0.1	0.5	0.6
Sitting height	0.1	0.8	2.0	0.4	1.2	0.9	0.6	1.4	1.3	1.2	0.9	0.2	0.9	-0.3	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	0.5	-0.2	-0.1	0.1	-0.2	-0.5	-0.3	-0.3	0.3	-0.3	0.2	0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.5	-0.1	0.1	0.3	-0.6	-0.1	0.1	0.0	0.4	0.2	0.2	0.4	0.7
Illnesses of siblings	0.1	0.2	0.4	-0.3	0.6	0.5	0.1	0.4	0.7	0.5	0.2	-0.2	0.6	0.3	-0.4
Weight	0.1	0.3	1.0	-0.4	-0.2	-0.9	0.4	0.4	-0.6	0.1	-0.6	-1.0	-0.1	0.1	-0.4
Alcohol intake versus 10 years previously	0.1	0.1	0.6	0.0	-0.3	-0.1	0.5	-0.5	-0.1	-0.5	-0.2	0.1	0.0	0.8	-0.4
Breastfed as a baby	0.1	0.1	0.5	-0.7	0.2	-0.3	0.1	0.0	-0.2	0.3	-0.3	-0.3	0.3	-0.5	-0.3
Blood clot in the leg (DVT)	0.1	0.1	0.6	-0.8	-0.3	-0.5	0.3	0.1	-0.5	-0.2	-0.3	-0.4	-0.2	-0.2	-0.1
Gout (self-reported)	0.1	0.2	0.7	0.5	0.3	0.5	-0.3	0.2	-0.1	0.3	0.8	0.5	0.4	-0.1	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.6	0.2	-0.1	0.5	-0.0	-0.8	-0.7	-0.2	-0.5	-0.0	0.4	0.0	-0.0
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.6	-0.1	0.4	0.2	-0.3	-0.4	-0.1	0.3	-0.2	-0.0	0.8	0.4	-0.6
Smoking status: Previous	0.1	0.1	0.5	0.1	-0.1	-0.7	-0.1	0.5	-0.4	0.1	-0.2	-0.6	-0.3	-0.2	-0.2
Smoking status: Current	0.1	0.2	0.7	-0.3	0.4	0.5	-0.3	0.9	-0.5	0.4	0.3	0.2	-0.3	-0.6	-0.5
Average weekly champagne plus white wine intake	0.1	0.2	0.9	0.6	0.0	0.0	1.0	0.1	0.5	0.0	0.5	0.5	0.1	-0.6	0.1
Ever taken oral contraceptive pill	0.1	0.1	0.3	-0.6	-0.4	-0.1	0.1	-0.3	-0.3	-0.5	-0.2	-0.4	-0.4	-0.3	-0.3
Medication: Lisinopril	0.1	0.2	0.9	-0.5	0.2	-0.5	0.9	0.4	-0.2	0.1	0.3	0.3	0.2	0.2	-0.5
Pain experienced in last month	0.1	0.1	0.3	-0.1	0.3	0.5	-0.6	-0.2	0.5	-0.0	-0.1	-0.0	-0.0	0.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	-0.5	-0.4	-0.4	0.5	0.1	-0.5	-0.2	-0.3	-0.3	-0.2	-0.3	-0.2
Alcohol drinker status: Previous	0.1	0.1	0.6	0.5	0.0	-0.5	-0.0	-0.2	0.8	-0.0	-0.1	0.1	0.4	-0.1	0.5
Schizophrenia vs Biploar Disorder	0.0	0.0	0.6	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.8
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

CRK

Models

Trait associations