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chr19:7,793,502-9,273,800

Best TWAS P=2.74e-28 · Best GWAS P=9.58e-34 conditioned to 1.29e-15

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYO1F	0.05	0.01	blup	42	0.03	2.2e-04	-8.2	-11.0	2.7e-28	0.31	0.03	0.36	TRUE
14	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PRAM1	0.03	0.01	blup	44	0.01	7.3e-02	3.8	-5.7	9.6e-09	0.09	0.03	0.26	TRUE
15	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZNF414	0.04	0.01	blup	39	0.02	1.9e-03	-7.4	-8.2	2.9e-16	0.05	0.13	0.64	FALSE
2	GTEx	Esophagus Muscularis	ZNF414	0.18	0.09	lasso	3	0.07	3.2e-05	-7.4	-8.0	1.7e-15	0.01	0.85	0.03	FALSE
16	The Cancer Genome Atlas	Stomach Adenocarcinoma	PRAM1	0.05	0.02	blup	44	0.01	3.4e-02	-7.4	-7.8	5.4e-15	0.04	0.01	0.74	FALSE
3	GTEx	Nerve Tibial	ZNF414	0.18	0.08	lasso	6	0.09	5.3e-07	-7.3	-7.5	6.0e-14	0.00	1.00	0.00	FALSE
10	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ZNF414	0.09	0.14	lasso	4	0.13	9.6e-08	-7.3	-7.5	8.6e-14	0.01	0.30	0.69	FALSE
8	ROSMAP	Brain Pre-frontal Cortex	ZNF414	0.07	0.07	lasso	4	0.06	2.7e-08	-7.4	-7.4	1.4e-13	0.00	1.00	0.00	FALSE
13	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MYO1F	0.04	0.00	blup	42	0.02	1.4e-03	-8.2	-6.6	3.3e-11	0.13	0.02	0.03	FALSE
12	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF414	0.06	0.03	blup	40	0.04	4.4e-05	-7.4	-6.6	3.7e-11	-0.01	0.14	0.39	FALSE
9	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PRAM1	0.04	0.00	blup	44	0.00	8.7e-02	-7.4	-6.3	3.0e-10	0.01	0.01	0.31	FALSE
6	GTEx	Vagina	MARCH2	0.60	0.05	enet	24	0.14	4.3e-04	4.5	5.7	1.5e-08	-0.04	0.06	0.06	FALSE
5	GTEx	Stomach	MARCH2	0.33	0.05	enet	27	0.11	6.9e-06	3.6	5.5	4.4e-08	-0.04	0.95	0.01	FALSE
1	GTEx	Esophagus Gastroesophageal Junction	MARCH2	0.40	0.24	enet	52	0.25	1.2e-09	3.8	5.4	5.2e-08	-0.05	0.97	0.00	FALSE
7	ROSMAP	Brain Pre-frontal Cortex	PRAM1	0.04	0.00	enet	15	0.01	4.5e-02	2.8	-5.3	8.8e-08	0.21	0.14	0.18	FALSE
4	GTEx	Skin Not Sun Exposed Suprapubic	MARCH2	0.42	0.33	enet	27	0.35	5.6e-20	3.9	5.2	2.3e-07	-0.09	1.00	0.00	FALSE