Best TWAS P=2.74e-28 · Best GWAS P=9.58e-34 conditioned to 1.29e-15
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Gastroesophageal Junction | MARCH2 | 0.40 | 0.24 | enet | 52 | 0.25 | 1.2e-09 | 3.8 | 5.4 | 5.2e-08 | -0.05 | 0.97 | 0.00 | FALSE |
| 2 | GTEx | Esophagus Muscularis | ZNF414 | 0.18 | 0.09 | lasso | 3 | 0.07 | 3.2e-05 | -7.4 | -8.0 | 1.7e-15 | 0.01 | 0.85 | 0.03 | FALSE |
| 3 | GTEx | Nerve Tibial | ZNF414 | 0.18 | 0.08 | lasso | 6 | 0.09 | 5.3e-07 | -7.3 | -7.5 | 6.0e-14 | 0.00 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | MARCH2 | 0.42 | 0.33 | enet | 27 | 0.35 | 5.6e-20 | 3.9 | 5.2 | 2.3e-07 | -0.09 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Stomach | MARCH2 | 0.33 | 0.05 | enet | 27 | 0.11 | 6.9e-06 | 3.6 | 5.5 | 4.4e-08 | -0.04 | 0.95 | 0.01 | FALSE |
| 6 | GTEx | Vagina | MARCH2 | 0.60 | 0.05 | enet | 24 | 0.14 | 4.3e-04 | 4.5 | 5.7 | 1.5e-08 | -0.04 | 0.06 | 0.06 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | PRAM1 | 0.04 | 0.00 | enet | 15 | 0.01 | 4.5e-02 | 2.8 | -5.3 | 8.8e-08 | 0.21 | 0.14 | 0.18 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | ZNF414 | 0.07 | 0.07 | lasso | 4 | 0.06 | 2.7e-08 | -7.4 | -7.4 | 1.4e-13 | 0.00 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PRAM1 | 0.04 | 0.00 | blup | 44 | 0.00 | 8.7e-02 | -7.4 | -6.3 | 3.0e-10 | 0.01 | 0.01 | 0.31 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ZNF414 | 0.09 | 0.14 | lasso | 4 | 0.13 | 9.6e-08 | -7.3 | -7.5 | 8.6e-14 | 0.01 | 0.30 | 0.69 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MYO1F | 0.05 | 0.01 | blup | 42 | 0.03 | 2.2e-04 | -8.2 | -11.0 | 2.7e-28 | 0.31 | 0.03 | 0.36 | TRUE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZNF414 | 0.06 | 0.03 | blup | 40 | 0.04 | 4.4e-05 | -7.4 | -6.6 | 3.7e-11 | -0.01 | 0.14 | 0.39 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MYO1F | 0.04 | 0.00 | blup | 42 | 0.02 | 1.4e-03 | -8.2 | -6.6 | 3.3e-11 | 0.13 | 0.02 | 0.03 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PRAM1 | 0.03 | 0.01 | blup | 44 | 0.01 | 7.3e-02 | 3.8 | -5.7 | 9.6e-09 | 0.09 | 0.03 | 0.26 | TRUE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZNF414 | 0.04 | 0.01 | blup | 39 | 0.02 | 1.9e-03 | -7.4 | -8.2 | 2.9e-16 | 0.05 | 0.13 | 0.64 | FALSE |
| 16 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PRAM1 | 0.05 | 0.02 | blup | 44 | 0.01 | 3.4e-02 | -7.4 | -7.8 | 5.4e-15 | 0.04 | 0.01 | 0.74 | FALSE |