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chr19:45,162,038-46,994,833

Best TWAS P=5.95e-12 · Best GWAS P=6.58e-11 conditioned to 0.681

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	GTEx	Thyroid	DMWD	0.11	0.12	lasso	3	0.11	6.7e-09	6.2	6.9	6.0e-12	-0.83	0.02	0.98	TRUE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	APOC4	0.06	0.03	blup	34	0.04	8.4e-06	-5.7	-6.0	2.2e-09	0.10	0.01	0.99	TRUE
1	GTEx	Adipose Visceral Omentum	DMWD	0.11	0.13	lasso	2	0.16	7.3e-09	6.1	6.8	7.3e-12	-0.85	0.02	0.98	FALSE
4	GTEx	Lung	DMPK	0.10	0.05	lasso	3	0.05	5.4e-05	6.2	6.8	9.1e-12	-0.77	0.02	0.98	FALSE
11	GTEx	Thyroid	DMPK	0.13	0.11	lasso	2	0.12	1.3e-09	6.2	6.8	1.3e-11	-0.78	0.03	0.97	FALSE
24	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SIX5	0.05	0.05	lasso	8	0.03	7.6e-03	-6.1	-6.5	6.9e-11	0.98	0.02	0.90	FALSE
14	GTEx	Whole Blood	DMPK	0.07	0.04	lasso	5	0.02	2.2e-03	6.2	6.4	1.5e-10	-0.55	0.03	0.95	FALSE
6	GTEx	Nerve Tibial	DMWD	0.24	0.07	lasso	6	0.06	5.8e-05	-6.1	6.4	2.1e-10	-0.86	0.02	0.98	FALSE
3	GTEx	Artery Tibial	DMWD	0.22	0.17	lasso	8	0.16	6.8e-13	-6.1	6.3	2.2e-10	-0.97	0.01	0.99	FALSE
15	GTEx	Whole Blood	AC074212.6	0.07	0.04	lasso	3	0.02	4.2e-03	6.2	6.2	4.5e-10	-0.57	0.03	0.95	FALSE
8	GTEx	Skin Sun Exposed Lower leg	DMWD	0.10	0.07	lasso	4	0.07	4.1e-06	6.1	6.2	5.1e-10	-0.59	0.03	0.96	FALSE
7	GTEx	Skin Sun Exposed Lower leg	DMPK	0.13	0.08	lasso	3	0.07	2.5e-06	6.1	6.2	5.5e-10	-0.60	0.03	0.97	FALSE
10	GTEx	Testis	DMWD	0.19	0.15	lasso	3	0.13	2.7e-06	6.3	6.2	5.9e-10	-0.60	0.03	0.96	FALSE
13	GTEx	Thyroid	AC074212.6	0.08	0.10	lasso	2	0.09	1.8e-07	-6.1	6.2	6.9e-10	-0.95	0.02	0.98	FALSE
2	GTEx	Artery Aorta	DMWD	0.28	0.19	lasso	3	0.15	1.2e-08	-6.1	6.0	1.6e-09	-0.94	0.02	0.98	FALSE
23	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	APOC2	0.27	0.25	enet	14	0.24	3.8e-14	-5.5	5.8	5.0e-09	-0.12	0.00	1.00	FALSE
5	GTEx	Muscle Skeletal	DMWD	0.06	0.01	lasso	6	0.01	1.9e-02	-6.1	5.8	7.8e-09	-0.91	0.02	0.96	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	DMWD	0.01	0.00	blup	42	0.01	7.3e-03	1.5	-5.7	1.4e-08	0.83	0.01	0.74	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	APOC2	0.13	0.13	lasso	5	0.16	8.6e-16	-5.5	5.7	1.5e-08	-0.13	0.00	1.00	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	APOC2	0.19	0.27	lasso	3	0.26	1.9e-29	-5.7	5.7	1.6e-08	-0.13	0.00	1.00	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	FOXA3	0.03	0.02	blup	53	0.02	1.9e-04	-6.5	5.6	1.8e-08	-0.77	0.00	0.99	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	APOE	0.03	0.02	enet	7	0.02	3.7e-03	-5.7	-5.6	1.9e-08	0.14	0.00	0.96	FALSE
27	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	APOC2	0.16	0.27	lasso	4	0.27	4.0e-31	-5.7	5.5	2.9e-08	-0.13	0.00	1.00	FALSE
20	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	APOC2	0.13	0.22	lasso	4	0.21	8.6e-23	-5.7	5.5	3.0e-08	-0.14	0.00	1.00	FALSE
9	GTEx	Skin Sun Exposed Lower leg	AC074212.6	0.13	0.08	enet	27	0.08	7.2e-07	6.1	5.5	3.1e-08	-0.58	0.03	0.97	FALSE
29	The Cancer Genome Atlas	Stomach Adenocarcinoma	APOC2	0.08	0.07	enet	6	0.03	2.2e-03	-5.6	5.5	3.5e-08	-0.11	0.00	0.99	FALSE
30	The Cancer Genome Atlas	Testicular Germ Cell Tumors	APOC2	0.14	0.15	enet	5	0.16	3.5e-06	-5.7	5.5	3.6e-08	-0.13	0.00	0.99	FALSE
16	YFS	Blood	DMWD	0.06	0.04	enet	19	0.05	3.8e-15	6.1	5.5	4.9e-08	-0.46	0.04	0.96	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	APOC2	0.18	0.20	enet	15	0.25	8.1e-51	-4.9	5.3	9.8e-08	-0.08	0.02	0.98	FALSE
28	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	APOC2	0.27	0.18	enet	12	0.29	1.1e-19	-4.7	5.3	1.1e-07	-0.08	0.01	0.99	FALSE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	APOC2	0.24	0.24	enet	12	0.27	4.2e-31	-5.6	5.2	1.7e-07	-0.09	0.00	1.00	FALSE