TWAS hub - APOE

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0590	0.0226	5.1e-06	0.048	0.016	0.033	NA	0.041	3.2e-10	2.8e-04	2.4e-07	NA	7.9e-09
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0348	0.0176	7.8e-03	0.024	0.012	0.018	NA	0.015	8.0e-04	1.6e-02	3.7e-03	NA	6.5e-03
3	TCGA	Lung Adenocarcinoma	0.0446	0.0203	1.4e-03	0.041	0.026	0.034	NA	0.039	1.2e-05	4.1e-04	6.2e-05	NA	2.2e-05
4	TCGA	Lung Squamous Cell Carcinoma	0.0648	0.0299	2.0e-03	-0.001	0.007	0.002	NA	0.003	3.9e-01	4.5e-02	1.8e-01	NA	1.5e-01
5	TCGA	Ovarian Serous Cystadenocarcinoma	0.1170	0.0410	1.0e-05	0.053	0.074	0.066	NA	0.055	1.7e-04	9.5e-06	3.2e-05	NA	1.4e-04
6	TCGA	Prostate Adenocarcinoma	0.0962	0.0346	1.2e-05	0.079	0.027	0.070	NA	0.071	1.1e-08	7.4e-04	9.1e-08	NA	6.7e-08
7	TCGA	Stomach Adenocarcinoma	0.1280	0.0560	4.2e-04	0.088	0.054	0.100	NA	0.107	6.4e-07	9.0e-05	1.0e-07	NA	3.9e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Alzheimer’s Disease (including proxy)	51.8	75.1	334.9	7.5	2.8	7.2	-18.3	-3.6	7.2	3.4
Alzheimer’s Disease (in mother)	19.5	22.9	93.9	4.6	0.3	4.3	-9.7	-2.4	4.3	1.4
Triglycerides	17.0	27.9	60.5	4.3	4.4	4.2	-7.7	7.8	4.2	1.7
HDL Cholesterol	12.5	20.9	38.8	4.7	3.8	4.9	3.5	3.3	4.8	6.2
Alzheimer’s Disease (in father)	10.9	11.9	73.6	1.7	0.1	1.6	-8.6	-1.2	1.6	0.4
LDL Cholesterol	9.6	15.2	85.4	2.1	0.4	1.4	9.2	-2.2	1.4	-2.6
Wears glasses or contact lenses	5.6	6.5	10.2	3.0	2.2	3.0	1.5	1.1	3.0	3.2
Health satisfaction	5.5	7.2	8.9	2.9	2.7	2.9	1.2	3.0	2.9	2.7
Supplements: Fish oil (including cod liver oil)	5.1	6.7	8.9	3.0	2.2	2.9	2.1	1.9	2.9	2.9
Bipolar Disorder (2018)	4.9	7.8	9.7	3.1	2.3	3.1	2.5	2.5	3.1	2.7
High blood pressure (siblings)	4.2	6.1	10.1	-3.1	-1.4	-3.0	0.4	-2.0	-2.9	-3.2
Handedness (chirality/laterality): Left-handed	4.0	4.8	8.4	2.8	0.7	2.6	-0.4	1.7	2.6	2.9
Bipolar Disorder or Schizophrenia	3.8	9.3	11.7	3.3	3.4	3.4	1.7	3.1	3.3	2.7
Primary Biliary Cirrhosis	3.7	5.3	10.0	2.1	1.6	2.1	3.0	1.6	2.1	3.2
Serious illness, injury or assault to yourself	3.7	4.5	8.1	2.1	2.8	2.2	1.9	1.7	2.1	1.7
Blood Eosinophil Count	3.6	27.6	48.0	-4.7	-4.7	-4.9	6.9	-6.8	-5.0	-2.5
Medication: Omeprazole (e.g. Zanprol)	3.5	4.3	7.6	-2.2	-2.7	-2.2	-1.1	-1.0	-2.2	-2.2
Average weekly fortified wine intake	3.4	3.9	6.2	-2.4	-0.9	-2.3	-1.8	0.9	-2.5	-2.4
Worrier / anxious feelings	3.4	6.4	9.5	2.9	2.7	3.0	0.8	1.7	3.1	2.6
Glaucoma (self-reported)	3.3	3.8	6.4	-2.2	-1.6	-2.1	-1.8	-0.8	-2.2	-2.5
Tinnitus: Yes, now most or all of the time	3.1	3.6	6.1	-2.4	-1.5	-2.4	-1.6	-0.3	-2.5	-1.5
Cardiovascular Disease	2.8	9.2	23.2	2.9	2.5	2.8	4.8	2.6	2.8	2.0
Exposure to tobacco smoke at home	2.8	3.2	7.5	1.1	2.7	1.3	1.6	2.6	1.2	1.1
Miserableness	2.8	4.8	7.8	2.7	1.5	2.7	0.6	1.1	2.7	2.8
Prospective memory result	2.6	3.2	5.5	2.3	1.7	2.2	0.6	0.7	2.2	1.7
Medication: Omeprazole	2.6	3.2	5.7	-1.8	-2.4	-1.8	-1.4	-0.6	-1.8	-2.1
Loud music exposure frequency	2.5	2.7	4.0	1.8	1.7	1.8	0.9	-1.0	1.9	2.0
Commuting to job workplace: Car/motor vehicle	2.5	2.9	4.3	-1.9	-2.1	-2.0	-0.2	-1.6	-1.9	-1.5
Relative age voice broke	2.4	3.7	5.7	-2.2	-1.7	-2.2	0.4	-2.4	-2.3	-1.5
Hip circumference	2.4	10.2	13.8	-3.3	-3.7	-3.3	-3.5	-2.0	-3.3	-3.0
High cholesterol (Self-reported)	2.4	4.3	9.7	2.1	0.6	1.9	2.9	3.1	1.8	0.4
Alcohol intake versus 10 years previously	2.3	3.5	7.0	2.6	0.6	2.6	1.1	1.1	2.5	1.3
Weight	2.2	10.6	17.9	-3.5	-4.2	-3.5	-2.5	-1.7	-3.6	-3.2
Illnesses of father: Heart disease	2.2	3.1	4.2	-2.0	-1.9	-2.0	-0.1	-1.3	-2.1	-1.9
Blood White Count	2.1	15.6	48.0	3.2	2.8	3.4	6.9	-1.8	3.4	4.1
Systolic Blood Pressure	2.1	10.3	23.5	2.7	4.6	2.6	4.8	1.5	2.8	1.8
Hypothyroidism (self reported)	2.1	4.9	5.9	-2.3	-2.4	-2.4	-2.0	-1.5	-2.4	-2.4
Bilateral oophorectomy (both ovaries removed)	2.1	2.4	5.0	1.5	1.9	1.5	0.9	2.2	1.6	0.9
Medication: Ramipril	2.1	2.7	11.6	0.9	1.3	0.9	3.4	1.6	0.9	0.7
Trunk fat-free mass	2.1	11.8	24.4	-3.4	-4.9	-3.7	-2.4	-2.1	-3.6	-3.3
Leg fat-free mass (right)	2.1	11.2	22.8	-3.3	-4.8	-3.4	-2.4	-2.5	-3.4	-3.0
Leg predicted mass (right)	2.1	11.1	22.5	-3.3	-4.7	-3.4	-2.4	-2.5	-3.4	-3.0
Basal metabolic rate	2.1	11.8	23.3	-3.4	-4.8	-3.6	-2.6	-2.1	-3.6	-3.2
Heart disease (siblings)	2.1	2.6	4.5	-1.7	-2.1	-1.8	-0.4	-1.4	-1.7	-1.6
Leg fat-free mass (left)	2.0	10.5	21.1	-3.2	-4.6	-3.3	-2.5	-2.4	-3.4	-2.9
Multivitamins +/- minerals	2.0	2.6	4.7	1.6	1.4	1.5	0.8	1.9	1.5	2.2
Leg predicted mass (left)	2.0	10.6	21.1	-3.2	-4.6	-3.4	-2.4	-2.5	-3.4	-2.9
Trunk predicted mass	2.0	11.7	24.2	-3.4	-4.9	-3.6	-2.3	-2.1	-3.6	-3.2
Whole body fat-free mass	2.0	11.5	23.7	-3.3	-4.9	-3.6	-2.5	-2.1	-3.5	-3.1
Arm predicted mass (left)	2.0	10.2	18.6	-3.3	-4.3	-3.5	-2.3	-1.7	-3.5	-3.0
Mean Putamen Volume	1.9	2.2	5.3	-1.1	-1.1	-1.2	2.0	-2.3	-1.2	-0.8
Ever had hysterectomy (womb removed)	1.9	2.1	5.6	0.8	2.1	0.9	2.4	1.3	1.0	0.8
Fed-up feelings	1.9	3.4	5.9	2.1	1.8	2.1	-1.0	0.6	2.2	2.4
Age when periods started (menarche)	1.9	4.6	5.8	-2.4	-2.4	-2.4	-0.0	-2.3	-2.4	-2.2
Tense / ‘highly strung’	1.9	3.1	6.9	1.6	2.6	1.6	1.8	0.9	1.8	1.4
Whole body water mass	1.9	10.9	22.5	-3.3	-4.7	-3.5	-2.4	-2.1	-3.5	-3.1
Schizophrenia (2014)	1.8	4.0	10.4	1.9	3.2	1.9	1.0	1.8	2.0	1.6
Allergy or Eczema	1.8	4.8	9.9	-2.3	-3.1	-2.5	-1.3	-0.9	-2.6	-1.5
Relative age of first facial hair	1.8	3.7	5.6	-2.1	-2.2	-2.3	0.0	-1.0	-2.3	-2.4
Ever used hormone-replacement therapy (HRT)	1.8	2.3	6.0	1.2	1.4	1.3	1.1	2.5	1.2	1.5
Illnesses of father: High blood pressure	1.8	2.2	3.8	-1.8	-1.4	-1.9	-0.5	-1.3	-1.7	-1.2
Respiratory disease	1.7	3.7	8.6	-2.9	0.0	-2.7	0.6	-0.8	-2.8	-0.8
Medication: Blood pressure	1.7	3.0	5.6	1.4	2.3	1.4	2.4	1.5	1.4	1.4
Heart disease (mother)	1.7	2.1	8.3	-1.2	-0.3	-1.1	2.9	-0.5	-1.1	-1.6
Medication: Gliclazide	1.7	2.0	4.2	-1.6	-1.1	-1.5	2.0	-0.3	-1.5	-1.0
Arm fat-free mass (left)	1.7	8.9	17.5	-3.0	-4.2	-3.2	-2.4	-1.4	-3.2	-2.7
Alcohol drinker status: Previous	1.7	1.9	5.3	1.0	2.0	1.1	-0.5	2.3	1.1	0.6
Illnesses of siblings	1.6	2.2	3.8	1.9	0.3	1.9	-1.0	1.4	1.8	1.4
Mineral and other dietary supplements	1.6	2.1	4.5	-1.5	-1.3	-1.4	-1.3	-1.0	-1.4	-2.1
Illnesses of father: None of the above (group 1)	1.6	2.0	4.0	1.3	1.2	1.3	1.5	2.0	1.3	1.0
Ever had prostate specific antigen (PSA) test	1.6	1.8	2.5	1.3	1.4	1.4	1.6	1.3	1.3	0.9
Schizophrenia (2018)	1.5	3.1	6.6	1.7	2.6	1.8	0.1	1.9	1.8	1.4
Blood Platelet Count	1.5	17.0	35.4	4.1	4.1	4.1	3.3	1.9	4.3	6.0
Height	1.5	29.4	57.9	-4.5	-7.6	-4.8	-6.7	-3.4	-4.9	-4.9
Waist Hip Ratio (WHR)	1.5	6.8	21.9	1.7	3.1	1.8	4.7	1.6	1.7	2.1
Type 2 Diabetes (T2D) (2018)	1.5	2.8	6.5	1.2	1.7	1.2	2.5	1.5	1.3	1.9
Neuroticism score	1.5	3.1	5.9	2.1	1.5	2.1	0.5	0.7	2.1	2.4
Lung cancer (father)	1.5	1.7	6.9	0.4	1.9	0.5	-0.7	2.6	0.5	-0.6
Illnesses of mother	1.5	1.8	2.8	-1.7	-1.5	-1.6	-1.0	-0.5	-1.6	-1.1
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	4.8	-1.6	-2.2	-1.7	-2.1	-0.5	-1.7	-1.5
Pulse wave peak to peak time	1.5	1.8	3.7	-1.5	-1.0	-1.6	-0.6	-0.6	-1.4	-1.9
Ulcerative Colitis (UC)	1.4	2.7	3.9	-1.9	-1.1	-1.9	1.5	-1.4	-2.0	-1.4
Pack years adult smoking proportion	1.4	2.1	4.8	1.0	1.1	1.0	2.2	2.0	1.1	1.2
Current tobacco smoking	1.4	2.3	3.0	1.7	1.6	1.6	1.6	0.5	1.7	1.5
Arm fat-free mass (right)	1.4	7.4	15.6	-2.7	-4.0	-2.9	-2.2	-1.4	-2.9	-2.4
Angina (self-reported)	1.4	1.9	3.8	-0.8	-1.9	-0.8	2.0	-1.4	-0.9	-1.4
Medication: Metformin	1.3	1.8	11.0	-0.6	0.3	-0.6	3.3	0.6	-0.5	-0.2
Arm fat mass (right)	1.3	5.3	7.4	-2.7	-2.6	-2.6	-1.6	-0.9	-2.7	-2.3
Standing height	1.3	12.6	31.6	-2.7	-5.6	-3.1	-3.4	-3.3	-3.0	-2.9
Wheeze or whistling in the chest in last year	1.3	2.3	5.0	-2.2	-0.1	-2.1	1.0	-0.7	-2.1	-1.1
Ever had bowel cancer screening	1.3	1.6	2.6	-1.4	-1.4	-1.4	0.6	-0.3	-1.4	-1.6
Neuroticism	1.2	3.0	4.9	1.8	1.6	1.9	1.8	0.4	1.9	2.2
Angina	1.2	1.6	4.2	-0.6	-1.8	-0.6	2.1	-1.2	-0.7	-1.0
High blood pressure (mother)	1.2	1.7	10.1	0.4	0.7	0.3	3.2	0.8	0.4	0.4
Trunk fat mass	1.2	5.1	8.6	-2.3	-2.9	-2.3	-2.1	-1.1	-2.4	-2.1
Medication: Simvastatin	1.2	1.8	10.8	-0.2	-0.8	-0.5	3.3	-0.2	-0.4	-0.7
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	3.8	-1.0	-1.5	-1.0	0.0	-2.0	-1.0	-1.4
Arm predicted mass (right)	1.2	6.2	12.5	-2.5	-3.5	-2.7	-2.1	-1.2	-2.6	-2.2
Smoking status: Current	1.2	2.0	3.3	1.5	1.4	1.5	1.8	0.0	1.5	1.3
Pack years of smoking	1.2	1.7	5.8	0.8	0.8	0.8	2.4	1.7	0.9	0.9
Lupus	1.1	1.7	2.9	1.5	1.1	1.6	0.9	0.8	1.7	1.3
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	2.1	1.5	0.2	1.3	0.8	0.1	1.4	1.1
Qualifications: CSEs or equivalent	1.1	1.5	2.5	1.6	0.9	1.5	-0.3	0.9	1.5	1.3
Supplements: Glucosamine	1.1	1.5	4.3	1.2	0.6	1.2	1.0	0.6	1.2	2.1
Diabetes (self-reported)	1.1	1.7	10.0	0.5	0.3	0.5	3.2	0.6	0.6	0.6
Comparative height size at age 10	1.1	6.1	15.4	-1.9	-3.9	-2.2	-2.3	-2.0	-2.1	-2.2
Hypertension (Self-reported)	1.1	3.1	11.1	1.2	2.0	1.1	3.3	1.2	1.2	1.0
Illnesses of siblings: Diabetes	1.1	1.4	9.3	0.2	0.7	0.1	3.0	0.1	0.2	0.0
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	9.4	-0.5	-2.1	-0.7	-3.1	-0.8	-0.7	-0.4
Diabetes diagnosed by doctor	1.1	1.8	12.0	-0.3	-0.1	-0.2	3.5	0.7	-0.1	0.4
Friendships satisfaction	1.1	1.4	3.4	1.3	0.1	1.2	1.9	-0.8	1.2	1.2
Mother’s age at death	1.1	1.4	3.2	-1.8	-0.6	-1.7	0.3	-0.1	-1.7	-0.7
Average weekly spirits intake	1.0	1.2	1.8	-1.3	-1.2	-1.2	-1.3	-0.1	-1.3	-0.5
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.7	1.4	0.9	1.4	-0.4	0.6	1.3	1.6
High blood pressure	1.0	2.7	10.9	1.0	1.7	0.9	3.3	1.2	1.0	0.6
Stomach or abdominal pain in last month	1.0	1.2	3.7	-0.8	-1.9	-0.9	-0.2	-1.6	-0.9	0.1
Number of live births	1.0	1.5	2.6	-1.0	-1.6	-1.0	-1.6	-1.1	-1.1	-0.9
Asthma	1.0	2.0	4.9	-2.2	0.3	-2.0	0.5	-0.2	-2.1	-0.3
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.3	1.3	1.1	1.3	-0.0	0.4	1.2	1.5
Shortness of breath walking on level ground	1.0	1.2	3.3	0.8	1.8	1.0	0.8	0.8	1.0	1.0
Medication: Seretide 50 evohaler	1.0	1.2	4.2	-1.0	-0.8	-0.9	-2.1	0.2	-0.9	0.7
Whole body fat mass	1.0	4.0	6.9	-2.2	-2.6	-2.2	-1.6	-0.6	-2.2	-2.0
Alcohol intake frequency.	1.0	2.2	7.2	1.1	1.4	1.1	-1.6	2.7	1.1	0.6
Asthma (self-reported)	1.0	2.0	5.0	-2.2	0.2	-2.0	0.7	-0.4	-2.1	-0.2
Arm fat mass (left)	1.0	4.3	5.8	-2.4	-2.4	-2.3	-1.7	-0.6	-2.4	-2.1
Eye problems/disorders: Glaucoma	1.0	1.2	2.9	-1.1	-0.7	-1.0	-1.2	-0.4	-1.0	-1.7
Pain type(s) experienced in last month: Hip pain	1.0	1.2	1.7	-1.2	-1.2	-1.2	-0.1	-1.2	-1.3	-1.0
Risk taking	1.0	1.5	3.5	-1.4	-0.9	-1.3	-0.5	-1.9	-1.3	-0.7
Ever depressed for a whole week	1.0	1.3	1.6	1.3	1.2	1.2	-0.6	1.1	1.2	1.1
Commuting to job workplace: Cycle	1.0	1.3	4.1	1.1	0.5	0.9	2.0	-0.0	1.0	1.2
Leg fat mass (left)	1.0	3.9	6.5	-2.3	-2.5	-2.3	-1.1	-0.4	-2.4	-1.9
Major Depression (MDD)	0.9	1.1	1.6	1.1	1.3	1.1	1.1	0.3	1.2	0.9
Age at First Birth	0.9	1.4	2.3	1.5	1.3	1.5	0.1	0.4	1.5	1.1
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.6	-0.3	1.1	-0.2	1.3	1.9	-0.2	-0.6
Hayfever, allergic rhinitis or eczema	0.9	2.1	4.6	-1.6	-2.1	-1.7	-0.6	-0.6	-1.8	-0.8
Hair/balding pattern: Pattern 2	0.9	1.1	3.7	-0.8	-0.9	-0.8	0.2	-1.9	-0.8	-1.2
Had other major operations	0.9	1.1	2.4	-1.5	-0.6	-1.3	0.1	0.4	-1.5	-0.7
Fluid intelligence score	0.9	1.9	3.9	-1.3	-2.0	-1.3	-1.3	-1.6	-1.2	-0.5
Depression (self-reported)	0.9	1.1	1.9	-1.2	0.1	-1.2	-0.5	-1.4	-1.1	-1.3
Pulse wave Arterial Stiffness index	0.9	1.1	2.7	1.3	0.4	1.3	0.2	0.5	1.1	1.6
Pulse wave reflection index	0.9	1.1	1.9	1.3	0.3	1.3	0.9	0.3	1.2	1.4
Birth weight	0.9	2.0	4.6	-0.8	-1.7	-0.8	-2.1	2.1	-0.7	-0.7
Leg fat mass (right)	0.9	3.4	5.5	-2.2	-2.3	-2.1	-1.2	-0.4	-2.2	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	4.1	0.6	0.6	0.7	-0.9	2.0	0.7	0.7
Average weekly beer plus cider intake	0.9	1.2	2.3	1.3	0.7	1.1	1.5	0.2	1.2	1.2
Myopia	0.9	1.3	5.4	0.6	1.0	0.8	2.3	-0.8	0.6	0.9
Cholesterol lowering medication	0.9	1.4	5.7	0.4	-1.7	0.2	2.4	0.6	0.1	-0.7
Basal cell carcinoma (self-reported)	0.9	1.1	2.8	1.0	0.9	1.0	1.7	0.6	1.1	0.8
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	5.2	-0.9	-0.8	-0.7	-2.3	0.1	-0.9	-0.7
Worry (Nagel 2018)	0.8	1.7	5.2	1.0	2.3	1.3	0.7	0.7	1.3	1.2
BMI	0.8	4.5	8.1	-2.8	-1.7	-2.8	-0.5	0.0	-2.8	-2.1
Sensitivity / hurt feelings	0.8	1.4	3.8	1.1	1.3	1.2	0.6	0.4	1.1	1.9
Sitting height	0.8	5.8	14.1	-1.5	-3.8	-1.8	-3.0	-2.6	-1.7	-1.5
Body mass index (BMI)	0.8	3.4	5.5	-2.3	-1.8	-2.2	-0.9	-0.3	-2.3	-1.9
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.4	1.2	1.0	1.1	-0.3	0.9	1.1	0.9
Had major operations	0.8	1.0	3.6	0.4	1.9	0.5	0.9	0.7	0.4	1.2
Mood swings	0.8	1.5	2.5	1.4	0.6	1.4	-1.2	0.3	1.4	1.6
Medication for cholesterol	0.8	1.2	4.0	-0.8	-0.5	-0.7	-1.5	-2.0	-0.8	-0.4
Hearing aid user	0.8	0.9	2.9	-1.1	0.3	-1.0	-0.2	0.3	-1.1	-1.7
Financial situation satisfaction	0.8	1.0	1.7	1.3	0.7	1.3	0.5	1.1	1.2	0.7
Depressed Affect (Nagel 2018)	0.7	1.5	3.6	1.5	0.5	1.5	-0.5	0.4	1.4	1.9
HbA1C	0.7	0.8	2.3	-0.9	0.4	-0.9	1.5	-0.9	-0.9	-0.1
Townsend deprivation index at recruitment	0.7	1.0	2.7	-0.7	-0.9	-0.8	1.1	-1.6	-0.8	-0.7
Waist circumference	0.7	2.4	4.0	-2.0	-1.5	-1.9	-0.7	-0.3	-2.0	-1.6
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.0	-1.4	-0.9	-1.2	0.2	-0.4	-1.4	-0.7
Arm fat percentage (right)	0.7	2.7	4.1	-2.0	-1.6	-1.9	-0.9	-0.8	-2.0	-1.8
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	1.7	1.2	0.8	1.3	0.0	1.1	1.2	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.6	-0.6	-0.8	-0.8	0.9	-1.6	-0.7	-0.5
Blood clot in the leg (DVT)	0.7	0.9	4.4	-0.7	-0.7	-0.5	-2.1	0.2	-0.7	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.3	0.7	0.8	0.7	1.8	-0.6	0.7	0.7
Medication: Aspirin	0.7	0.9	3.8	0.8	0.1	0.7	0.7	1.9	0.7	0.7
Average weekly red wine intake	0.7	1.0	3.7	-0.5	-0.6	-0.6	1.9	-1.4	-0.5	-0.3
Commuting to job workplace: Walk	0.7	0.8	1.3	-1.0	-0.1	-1.0	-1.0	-0.4	-1.0	-1.1
Breast cancer (self-reported)	0.7	0.8	1.8	0.3	1.1	0.4	1.0	1.3	0.3	1.1
Vascular/heart problems diagnosed by doctor	0.7	2.0	12.4	-0.2	-1.0	-0.1	-3.5	-0.5	-0.2	0.2
Irritable Bowel Disease (IBD)	0.6	1.4	2.2	-1.3	-0.8	-1.2	1.5	-1.4	-1.3	-0.6
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.4	-1.4	-1.5	-1.3	-1.2	-0.8	-1.2	-1.1
Ovarian Cancer	0.6	0.8	1.6	0.6	1.2	0.6	-0.4	1.2	0.6	1.2
Blood Red Count	0.6	5.9	11.6	-2.5	-2.2	-2.4	-3.4	-1.6	-2.4	-2.2
Hand grip strength (left)	0.6	1.5	5.5	-1.0	-2.4	-1.2	0.2	-0.0	-1.2	-1.2
Hearing difficulty/problems: Yes	0.6	0.9	3.5	-0.7	-0.1	-0.7	-1.2	0.5	-0.6	-1.9
Vitamin and mineral supplements	0.6	0.8	2.5	-0.9	-0.2	-0.8	-0.4	-1.0	-0.7	-1.6
Diabetes (mother)	0.6	0.7	4.2	-0.6	-0.3	-0.4	2.1	0.3	-0.4	-0.2
Impedance of leg (right)	0.6	3.0	4.5	2.1	1.9	2.0	0.7	0.8	2.1	2.0
Trunk fat percentage	0.6	2.5	3.5	-1.7	-1.9	-1.6	-1.6	-0.9	-1.6	-1.5
Taking other prescription medications	0.6	1.0	2.0	-1.2	0.4	-1.1	0.7	1.4	-1.2	-0.0
Medication: Levothyroxine sodium	0.6	1.0	4.2	-0.7	-0.9	-0.7	-2.1	-0.0	-0.7	-0.6
Mouth/teeth dental problems	0.6	0.9	2.2	0.7	0.5	0.6	-1.3	1.5	0.6	1.1
Birth weight of first child	0.6	1.0	1.7	-1.3	-0.8	-1.2	-0.8	-0.6	-1.2	-0.8
Number of full brothers	0.6	0.7	1.2	-1.1	0.5	-1.1	1.0	-0.4	-0.9	-0.5
Number of children fathered	0.6	0.6	1.7	0.0	-1.2	-0.3	1.3	-1.0	-0.0	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.2	0.8	0.8	0.8	-0.3	1.1	0.7	0.9
Arm fat percentage (left)	0.6	2.3	3.7	-1.9	-1.4	-1.8	-0.9	-0.6	-1.9	-1.7
Medication: Aspirin	0.6	0.7	2.6	0.7	-0.0	0.6	1.1	1.6	0.6	0.4
Medication: Blood pressure	0.6	1.1	6.2	0.2	0.4	0.1	2.5	1.0	0.2	0.0
Alcohol drinker status: Never	0.6	0.7	2.3	0.4	1.5	0.3	-0.7	1.4	0.4	-0.0
Depression (Nagel 2018)	0.5	0.7	1.6	1.0	0.1	1.1	0.1	-0.5	0.9	1.3
Prostate Cancer	0.5	0.7	1.5	0.6	1.1	0.5	1.2	1.2	0.5	0.3
Systolic blood pressure, automated reading	0.5	1.4	5.9	0.3	1.6	0.4	2.4	0.9	0.4	-0.3
Supplements: Zinc	0.5	0.6	1.5	-0.5	-1.2	-0.5	-1.2	-0.5	-0.5	0.1
Diabetes (father)	0.5	0.6	2.8	-0.6	0.6	-0.4	1.7	-0.1	-0.5	0.2
Hand grip strength (right)	0.5	1.2	4.7	-0.7	-2.2	-1.0	-0.7	0.2	-1.0	-1.1
Maternal smoking around birth	0.5	0.7	2.6	0.3	-0.4	0.2	1.6	-1.2	0.1	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.0	1.0	0.5	1.0	0.6	-0.8	1.0	1.0
Impedance of leg (left)	0.5	2.6	4.1	2.0	1.6	1.9	0.8	0.8	2.0	1.7
Allergy	0.5	1.2	2.5	1.5	1.1	1.5	0.5	0.4	1.6	-0.0
Father’s age at death	0.5	0.7	1.2	-0.8	-0.7	-0.7	0.7	-0.9	-0.8	-1.1
Hair/balding pattern: Pattern 3	0.5	0.8	1.0	0.9	1.0	0.9	0.5	0.9	0.9	1.0
Medication: Cholesterol lowering	0.5	0.8	4.1	0.3	-0.5	0.1	2.0	0.8	0.2	-0.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.8	-0.4	-1.2	-0.4	-1.3	-1.3	-0.3	0.0
Body fat percentage	0.5	1.9	2.7	-1.6	-1.6	-1.5	-0.9	-0.5	-1.6	-1.5
Chest pain or discomfort	0.5	0.8	1.3	-1.0	-0.9	-0.9	-1.1	-0.1	-1.0	-0.8
Knee pain experienced in last month	0.5	0.7	2.5	0.1	0.3	0.2	-1.6	1.5	0.1	0.2
Smoking status: Previous	0.5	0.7	1.9	-0.6	-1.4	-0.6	1.0	-0.7	-0.8	-0.6
Eye problems/disorders: Cataract	0.5	0.6	0.8	-0.9	-0.8	-0.9	-0.3	0.6	-0.9	-0.8
Number of self-reported non-cancer illnesses	0.5	0.8	4.4	-0.6	0.3	-0.6	2.1	0.2	-0.6	-0.4
Ever taken oral contraceptive pill	0.5	0.5	2.0	-0.4	-0.9	-0.5	1.4	-0.2	-0.4	-0.3
Medication: Lisinopril	0.5	0.7	4.5	0.0	0.2	-0.1	2.1	0.0	0.0	0.3
Medication: Atorvastatin	0.5	0.6	2.9	0.5	-0.3	0.5	0.5	1.7	0.4	-0.2
Leg fat percentage (left)	0.5	1.9	3.2	-1.8	-1.4	-1.7	-0.3	0.0	-1.8	-1.4
Number of operations (self-reported)	0.5	0.8	1.6	-1.3	-0.5	-1.1	0.5	-0.2	-1.3	-0.7
Impedance of whole body	0.5	2.8	4.7	2.1	1.7	2.1	0.1	0.1	2.2	1.8
Neuroticism (Nagel 2018)	0.4	1.0	2.2	0.8	1.3	1.0	0.8	-0.1	0.9	1.5
Body Mass Index (BMI) (2010)	0.4	0.5	1.8	0.1	1.2	0.2	-0.6	1.4	0.1	0.2
Crohns Disease (2012)	0.4	0.6	1.6	0.4	-0.1	0.4	1.0	-1.3	0.4	1.1
Fasting Glucose	0.4	0.5	1.1	-0.7	-0.6	-0.7	0.4	-0.4	-0.7	-1.0
Rheumatoid Arthritis	0.4	0.6	3.0	-0.3	-0.8	-0.4	-0.1	-1.7	-0.3	-0.6
Type 2 Diabetes (T2D) (2012)	0.4	0.5	2.8	-0.3	0.6	-0.2	1.7	0.0	-0.3	0.5
Smoking Status	0.4	0.9	3.8	0.8	0.3	0.8	1.9	-0.2	0.7	0.5
Chronic bronchitis/emphysema (father)	0.4	0.5	2.2	0.2	-0.7	0.0	1.5	-0.8	0.1	-0.2
Past tobacco smoking	0.4	0.8	2.0	0.6	1.4	0.6	-1.3	0.7	0.8	0.4
Alcohol usually taken with meals	0.4	0.6	1.8	-0.5	0.2	-0.5	1.4	-1.3	-0.4	-0.2
Financial difficulties in last 2 years	0.4	0.5	1.2	-0.7	-0.1	-0.7	-1.1	1.0	-0.6	-0.3
Happiness	0.4	0.4	1.8	0.2	0.6	0.3	-1.3	0.8	0.3	0.3
Mouth/teeth dental problems: Dentures	0.4	0.7	2.0	0.5	0.9	0.6	1.4	1.0	0.5	-0.1
Impedance of arm (left)	0.4	1.7	3.1	1.7	1.1	1.8	0.0	-0.5	1.8	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.1	1.0	0.1	1.0	-0.7	0.1	0.9	0.9
Medication: Amlodipine	0.4	0.6	1.6	0.5	1.1	0.6	1.3	0.4	0.5	0.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.3	-0.6	0.7	-0.6	1.1	-0.0	-0.6	0.6
Chronic bronchitis/emphysema (mother)	0.4	0.5	2.9	-0.6	0.1	-0.5	1.7	0.1	-0.4	-0.0
Exposure to tobacco smoke outside home	0.4	0.6	1.6	-0.7	-0.5	-0.7	1.3	-0.7	-0.7	-0.5
Eye problems/disorders: None of the above	0.4	0.5	1.1	0.8	-0.0	0.8	0.1	-1.0	0.7	0.8
Migraine (self-reported)	0.4	0.5	1.0	0.8	0.5	0.7	0.7	1.0	0.7	0.4
Mean time to correctly identify matches	0.4	0.7	3.3	-0.2	0.7	-0.2	1.8	-0.0	-0.3	-0.9
Leg pain on walking	0.4	0.5	1.0	-0.8	-0.3	-0.7	0.2	-1.0	-0.8	-0.6
Long-standing illness, disability or infirmity	0.4	0.6	1.1	-1.0	0.8	-0.8	-0.1	1.0	-0.9	-0.6
Average weekly champagne plus white wine intake	0.4	0.5	0.9	0.5	0.9	0.5	1.0	0.3	0.5	0.9
Guilty feelings	0.4	0.5	3.3	-0.4	-0.0	-0.3	0.3	-1.8	-0.3	0.1
Medication: Bendroflumethiazide	0.4	0.6	1.2	0.8	0.3	0.8	1.1	0.2	0.9	0.9
Age started oral contraceptive pill	0.4	0.6	1.9	0.3	0.6	0.4	1.1	1.4	0.3	0.2
Supplements: Calcium	0.4	0.4	1.4	-0.4	0.7	-0.4	-1.2	0.8	-0.4	0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.1	-0.5	-0.6	-0.5	0.1	0.1	-0.6	-1.4
Breast Cancer	0.3	0.8	1.3	-0.8	-1.1	-0.9	-1.1	0.2	-0.8	-1.0
Neuroticism (2016)	0.3	0.4	0.5	0.6	0.7	0.7	0.6	0.4	0.7	0.3
Number of treatments/medications taken	0.3	0.6	1.6	0.1	0.7	0.1	1.2	1.2	0.2	0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.7	-0.6	0.6	-0.5	0.6	0.8	-0.6	0.1
Medication for hormone replacement therapy	0.3	0.3	1.7	0.3	-0.2	0.3	0.0	1.3	0.3	-0.1
Severe depression (siblings)	0.3	0.4	1.4	-0.2	0.6	-0.0	1.2	-0.5	-0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.0	-0.9	-0.5	-1.0	-0.6	-0.5	-0.9	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.7	0.7	0.6	0.7	0.3	-0.7	0.6	0.9
Had menopause	0.3	0.4	0.9	-0.9	-0.4	-0.8	0.3	0.3	-0.9	-0.6
Qualifications: None of the above	0.3	0.6	1.0	1.0	0.6	0.9	0.9	0.7	1.0	0.5
Time employed in main current job	0.3	0.3	1.9	-0.3	0.2	-0.2	-1.4	-0.4	-0.2	0.0
Falls in the last year	0.3	0.4	0.8	0.7	0.3	0.8	-0.0	0.9	0.8	-0.2
Forced expiratory volume in 1-second (FEV1)	0.3	0.8	3.5	0.2	-1.9	-0.1	-1.3	-0.1	-0.1	-0.8
Medication: Lansoprazole	0.3	0.4	2.0	0.3	0.1	0.4	1.4	0.2	0.4	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.7	0.5	-1.6	0.3	-1.7	0.0	0.3	-0.1
Headache pain in last month	0.3	0.6	2.1	-0.1	-0.1	-0.0	-1.4	1.3	-0.0	0.1
Gout (self-reported)	0.3	0.4	0.9	-0.5	-0.7	-0.6	1.0	-0.4	-0.7	-0.5
Forced vital capacity (FVC), Best measure	0.3	1.0	4.2	0.6	-1.6	0.3	-2.0	-0.2	0.3	0.2
Leg fat percentage (right)	0.3	1.3	2.3	-1.5	-1.0	-1.4	-0.4	0.1	-1.5	-1.0
Medication for pain relief, constipation, heartburn	0.3	0.5	1.9	0.1	0.3	0.0	1.4	-1.2	-0.0	-0.3
Pulse rate, automated reading	0.3	1.0	4.8	0.2	0.9	0.4	-1.1	2.2	0.4	0.5
Number of full sisters	0.3	0.3	1.8	-0.1	0.3	-0.1	-1.3	0.5	-0.0	-0.1
Suffer from ‘nerves’	0.3	0.4	2.2	-0.2	0.4	-0.1	-1.5	0.5	-0.1	0.0
Overall health rating	0.3	0.7	1.6	0.7	0.8	0.8	-0.1	1.3	0.7	0.9
Age at last live birth	0.3	0.4	1.2	0.0	0.7	0.1	1.1	-0.6	-0.0	0.9
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.1	0.3	-0.8	0.4	-1.0	-0.4	0.2	0.1
Loneliness, isolation	0.3	0.4	1.6	-0.1	-0.9	-0.1	-1.3	-0.3	-0.1	0.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.6	2.4	-0.4	0.1	-0.4	1.5	-1.0	-0.2	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.1	0.2	-0.2	0.4	-1.1	-0.2	0.3	0.9
Medication: Paracetamol	0.3	0.4	2.0	-0.4	0.4	-0.3	-1.4	0.5	-0.4	-0.0
Ever smoked	0.3	0.5	2.2	0.3	-0.7	0.3	1.5	0.4	0.1	0.5
Fractured/broken bones in last 5 years	0.3	0.4	0.8	0.6	0.1	0.6	0.9	0.1	0.7	0.6
Pain experienced in last month	0.3	0.6	2.6	0.0	-0.1	0.1	1.6	-1.0	0.1	-0.7
Intelligence (Savage-Jansen 2018)	0.2	0.6	0.9	-1.0	-1.0	-0.9	0.2	-0.6	-0.9	-0.6
Crohns Disease (2017)	0.2	0.4	1.5	-0.2	-0.1	-0.1	1.2	-0.9	-0.2	0.1
Reaction Time	0.2	0.3	1.1	-0.1	0.7	-0.1	1.0	0.5	-0.1	-0.5
Ulcerative Colitis	0.2	0.3	0.6	-0.7	-0.3	-0.7	0.3	-0.1	-0.7	-0.8
Tanning	0.2	2.9	6.1	-1.9	-1.1	-1.9	0.2	-1.5	-1.9	-2.5
Medication: Co-codamol	0.2	0.2	0.3	-0.5	-0.0	-0.4	-0.6	-0.5	-0.5	-0.1
Nervous feelings	0.2	0.4	1.8	-0.3	0.9	-0.1	-1.4	0.3	-0.1	-0.1
Hearing difficulty/problems with background noise	0.2	0.3	1.2	-0.3	0.2	-0.3	-1.1	0.7	-0.1	-0.4
Forced vital capacity (FVC)	0.2	0.8	2.9	0.3	-1.7	0.0	-1.4	-0.4	-0.0	-0.7
Heart attack	0.2	0.3	1.4	-0.3	-0.3	-0.3	0.1	0.2	-0.4	-1.2
Pain all over the body in last month	0.2	0.2	0.6	0.3	0.5	0.2	0.8	0.0	0.3	-0.6
Impedance of arm (right)	0.2	1.1	1.8	1.4	0.6	1.4	-0.1	-0.9	1.3	1.0
Noisy workplace	0.2	0.3	0.5	-0.7	0.1	-0.6	-0.7	-0.0	-0.5	-0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.9	-0.3	-0.2	-0.3	1.4	-0.7	-0.3	0.5
Length of working week for main job	0.2	0.3	0.7	-0.4	-0.8	-0.4	-0.7	-0.0	-0.5	-0.3
Breastfed as a baby	0.2	0.2	0.6	0.0	-0.7	0.0	-0.7	0.8	0.0	-0.0
Peak expiratory flow (PEF)	0.2	0.4	2.3	0.5	-0.5	0.3	-0.1	1.5	0.4	0.1
Comparative body size at age 10	0.2	0.4	2.6	0.4	-1.6	0.1	0.0	-0.3	0.1	0.4
Qualifications: College or University degree	0.2	0.7	2.4	-0.7	-1.0	-0.7	0.2	-1.5	-0.7	-0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.8	0.4	-0.6	0.2	-0.1	-0.9	0.3	0.0
Emphysema/chronic bronchitis	0.2	0.3	0.5	-0.7	0.3	-0.6	-0.2	0.4	-0.6	-0.5
Neck or shoulder pain in last month	0.2	0.3	1.5	-0.2	0.4	-0.0	-1.2	-0.3	-0.2	-0.3
Medication: Ibuprofen	0.2	0.3	0.5	-0.4	-0.4	-0.4	-0.7	-0.6	-0.4	0.5
Medication: Allopurinol	0.2	0.2	0.3	-0.4	-0.4	-0.5	-0.4	-0.5	-0.6	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	-0.2	-0.4	-0.3	0.6	-0.7	-0.3	-0.2
Back pain experienced in last month	0.2	0.3	0.8	0.1	-0.1	0.0	-0.8	0.9	-0.1	0.9
Osteoarthritis (self-reported)	0.2	0.3	1.1	0.4	0.4	0.5	-1.1	0.3	0.3	0.6
Commuting to job workplace: Public transport	0.2	0.2	0.4	0.6	0.4	0.4	0.4	0.6	0.6	0.2
Irritability	0.2	0.3	0.6	0.5	-0.2	0.5	0.6	-0.5	0.4	0.8
Lung FEV1/FVC ratio	0.1	0.3	0.7	0.5	-0.8	0.4	0.5	0.7	0.3	0.5
Lung FVC	0.1	0.5	1.0	1.0	-0.6	0.8	-0.5	1.0	0.8	-0.3
Chronotype (morning person)	0.1	0.3	0.7	0.8	-0.7	0.7	0.4	0.0	0.6	-0.3
Hair Pigment	0.1	2.9	14.2	1.0	0.7	1.0	-1.6	3.8	1.0	0.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	-0.4	-0.4	-0.2	-0.3	0.5	-0.3	0.2
Medication: Atenolol	0.1	0.2	0.5	-0.3	0.3	-0.3	0.3	0.7	-0.3	-0.4
Number of incorrect matches in round	0.1	0.2	0.3	0.4	0.3	0.4	-0.6	0.2	0.4	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	0.4	0.6	0.3	-0.6	0.3	0.4	0.7
Pulse rate	0.1	0.1	0.8	-0.1	0.2	-0.1	0.2	0.9	-0.2	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	-0.3	-0.2	-0.3	-0.5	-0.3	-0.2	0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.8	-0.4	-0.4	-0.4	0.9	0.0	-0.4	-0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.6	-0.2	-0.4	-0.3	0.5	-0.8	-0.4	0.2
Medication: Paracetamol	0.1	0.2	1.4	-0.1	0.4	-0.0	-1.2	0.4	-0.1	0.1
Worry too long after embarrassment	0.1	0.2	0.4	0.3	0.2	0.2	0.6	0.3	0.2	0.6
Age at first live birth	0.1	0.2	0.6	0.0	0.8	0.0	0.6	-0.8	0.0	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.6	-0.1	-0.4	-0.2	0.7	0.4	-0.2	0.3
Family relationship satisfaction	0.1	0.1	0.4	0.2	-0.6	0.1	0.2	-0.6	0.2	0.0
Supplements: Vitamin C	0.1	0.1	0.4	0.0	-0.3	-0.0	0.7	0.4	-0.2	0.6
Qualifications: nursing, teaching	0.1	0.2	0.6	0.0	0.6	0.1	-0.8	0.4	0.1	0.6
Osteoporosis (self-reported)	0.1	0.2	0.8	-0.1	0.2	-0.0	0.1	0.9	-0.0	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.8	-0.0	-0.8	-0.2	-0.5	0.9	-0.2	0.2
Diastolic blood pressure, automated reading	0.1	0.3	0.7	0.2	0.8	0.2	0.8	0.9	0.2	-0.1
Unable to work because of sickness or disability	0.1	0.1	0.2	0.4	-0.4	0.4	0.0	0.1	0.5	0.1
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.0	0.2	0.4	0.3	0.6	0.4	-0.6	-0.6	0.3	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.1	0.3	0.2	0.2	0.2	0.0	-0.1	0.1	0.5

Hub : Genes

APOE

Models

Trait associations