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chr19:48,464,978-51,087,033

Best TWAS P=7.4e-13 · Best GWAS P=1.93e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	PRR12	0.11	0.10	lasso	1	0.09	1.0e-07	6.7	6.7	2.3e-11	0.99	0.00	1.00	FALSE
2	GTEx	Artery Aorta	PRR12	0.21	0.13	lasso	5	0.15	7.6e-09	4.9	5.8	9.2e-09	0.95	0.01	0.99	FALSE
3	GTEx	Brain Cerebellar Hemisphere	PRR12	0.27	0.12	lasso	5	0.10	2.0e-03	6.6	7.2	7.4e-13	0.96	0.01	0.88	TRUE
4	GTEx	Brain Cerebellar Hemisphere	AP2A1	0.33	0.05	lasso	7	0.06	1.1e-02	3.6	-5.3	1.2e-07	-0.26	0.06	0.31	FALSE
5	GTEx	Brain Cerebellum	PRR12	0.36	0.33	lasso	6	0.31	6.8e-10	6.6	6.8	9.5e-12	0.98	0.00	1.00	FALSE
6	GTEx	Brain Nucleus accumbens basal ganglia	BCAT2	0.33	0.12	lasso	9	0.08	3.6e-03	-4.8	5.3	1.2e-07	0.04	0.03	0.57	TRUE
7	GTEx	Breast Mammary Tissue	PRR12	0.23	0.09	lasso	6	0.11	3.3e-06	4.0	6.0	2.2e-09	0.75	0.02	0.98	FALSE
8	GTEx	Breast Mammary Tissue (Male)	PRR12	0.41	0.29	lasso	5	0.24	2.5e-06	4.0	6.1	1.3e-09	0.70	0.02	0.93	FALSE
9	GTEx	Cells Transformed fibroblasts	TBC1D17	0.11	0.03	enet	23	0.04	6.5e-04	-2.6	5.5	2.8e-08	0.12	0.87	0.01	TRUE
10	GTEx	Cells Transformed fibroblasts	PRR12	0.14	0.06	enet	14	0.10	4.5e-08	6.6	5.3	1.0e-07	0.78	0.00	0.99	FALSE
11	GTEx	Colon Sigmoid	PRR12	0.20	0.01	lasso	8	0.00	4.9e-01	6.7	6.9	4.9e-12	0.72	0.02	0.56	FALSE
12	GTEx	Colon Transverse	PRR12	0.27	0.09	enet	8	0.16	4.7e-08	4.2	6.7	2.8e-11	0.74	0.14	0.86	FALSE
13	GTEx	Esophagus Mucosa	PRR12	0.23	0.11	lasso	6	0.21	3.2e-14	4.2	6.6	5.3e-11	0.82	0.02	0.98	FALSE
14	GTEx	Esophagus Muscularis	PRR12	0.19	0.16	lasso	3	0.16	6.4e-10	6.7	6.6	3.9e-11	0.99	0.00	1.00	FALSE
15	GTEx	Esophagus Muscularis	CTB-33G10.11	0.09	0.00	lasso	4	0.00	2.7e-01	5.6	6.6	3.5e-11	0.87	0.01	0.90	FALSE
16	GTEx	Liver	PRRG2	0.23	0.10	lasso	2	0.12	3.1e-04	6.7	6.7	1.7e-11	0.99	0.00	0.98	FALSE
17	GTEx	Lung	PRR12	0.13	0.11	lasso	2	0.10	5.8e-08	6.7	6.8	7.2e-12	0.99	0.00	1.00	FALSE
18	GTEx	Nerve Tibial	PRR12	0.20	0.18	lasso	3	0.17	7.4e-12	6.7	6.7	2.3e-11	0.99	0.00	1.00	FALSE
19	GTEx	Pancreas	PRR12	0.19	0.17	lasso	2	0.16	3.8e-07	6.7	6.9	6.1e-12	0.95	0.00	0.99	FALSE
20	GTEx	Skin Sun Exposed Lower leg	PRRG2	0.23	0.18	lasso	3	0.21	1.3e-17	6.6	6.2	4.5e-10	0.97	0.01	0.99	FALSE
21	GTEx	Skin Sun Exposed Lower leg	NOSIP	0.13	0.12	lasso	1	0.11	3.2e-09	5.5	5.5	3.1e-08	0.68	0.64	0.36	FALSE
22	GTEx	Testis	NTN5	0.16	0.02	enet	23	0.06	9.6e-04	-3.9	-5.3	1.1e-07	0.00	0.04	0.50	FALSE
23	GTEx	Vagina	PRR12	0.49	0.14	lasso	6	0.32	4.6e-08	4.0	6.4	1.8e-10	0.30	0.09	0.27	FALSE
24	METSIM	Adipose	PRR12	0.06	0.06	enet	10	0.06	9.4e-09	6.7	6.8	9.5e-12	0.98	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	PRR12	0.04	0.03	lasso	4	0.02	1.1e-05	5.2	5.8	7.2e-09	0.82	0.02	0.96	FALSE
26	The Cancer Genome Atlas	Colon Adenocarcinoma	PRR12	0.04	0.02	blup	30	0.03	7.1e-03	5.7	6.2	8.0e-10	0.88	0.02	0.52	FALSE
27	The Cancer Genome Atlas	Colon Adenocarcinoma	PRRG2	0.05	0.05	lasso	2	0.02	1.9e-02	6.7	-6.7	2.0e-11	-0.99	0.00	0.91	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SEC1	0.14	0.13	lasso	2	0.13	1.6e-14	5.1	-5.1	2.9e-07	0.03	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PRR12	0.09	0.03	lasso	6	0.06	4.0e-04	4.2	6.1	1.1e-09	0.75	0.01	0.86	FALSE
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PRRG2	0.06	0.10	lasso	5	0.09	1.3e-05	5.2	5.4	5.7e-08	0.84	0.02	0.96	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	RPS11	0.03	0.01	enet	11	0.01	1.5e-02	3.7	-5.4	7.5e-08	-0.52	0.00	0.10	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEC1	0.16	0.11	lasso	4	0.11	2.1e-12	4.7	-5.4	5.7e-08	0.03	0.00	0.99	TRUE
33	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PRR12	0.03	0.00	blup	30	0.01	2.1e-02	4.2	5.7	1.1e-08	0.82	0.01	0.66	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	PRR12	0.03	0.00	blup	30	0.01	1.1e-02	6.7	5.1	2.9e-07	0.88	0.01	0.77	FALSE
35	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PRRG2	0.11	0.09	lasso	1	0.06	4.1e-03	5.2	5.2	2.3e-07	0.75	0.02	0.36	FALSE