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chr3:54,846,329-58,522,023

Best TWAS P=3.56e-28 · Best GWAS P=5.98e-29 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ERC2	0.12	0.00	bslmm	972	0.04	1.8e-05	-6.4	-6.4	1.4e-10	0.22	0.59	0.03	TRUE
2	GTEx	Adipose Subcutaneous	FAM208A	0.12	0.09	enet	11	0.12	1.1e-09	-7.0	9.2	5.9e-20	-0.83	0.06	0.94	FALSE
3	GTEx	Adrenal Gland	RP11-755B10.4	0.11	0.06	lasso	11	0.04	1.4e-02	5.2	-5.2	2.2e-07	-0.01	0.28	0.07	FALSE
4	GTEx	Artery Tibial	RP11-755B10.4	0.11	0.06	enet	13	0.04	2.1e-04	5.2	-5.5	3.5e-08	-0.07	0.55	0.03	TRUE
5	GTEx	Brain Frontal Cortex BA9	CCDC66	0.16	0.18	lasso	3	0.14	1.3e-04	-4.8	5.4	7.1e-08	-0.54	0.16	0.36	FALSE
6	GTEx	Brain Hippocampus	CCDC66	0.23	0.23	lasso	3	0.20	2.1e-05	-7.4	7.1	9.1e-13	-0.66	0.24	0.20	FALSE
7	GTEx	Breast Mammary Tissue (Male)	CCDC66	0.05	0.03	lasso	3	0.04	5.1e-02	-7.0	5.6	1.9e-08	-0.41	0.05	0.08	TRUE
8	GTEx	Breast Mammary Tissue (Female)	CCDC66	0.16	0.06	enet	10	0.14	4.3e-05	-4.8	5.3	1.4e-07	-0.55	0.07	0.62	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	CCDC66	0.45	0.27	enet	37	0.29	3.7e-10	-7.7	-7.4	1.5e-13	0.46	0.98	0.01	FALSE
10	GTEx	Cells Transformed fibroblasts	FAM208A	0.10	0.00	lasso	4	0.00	1.3e-01	-10.9	9.9	3.9e-23	-0.82	0.03	0.91	FALSE
11	GTEx	Liver	PDE12	0.23	0.00	enet	20	0.03	6.6e-02	3.3	-5.5	4.5e-08	0.02	0.05	0.40	FALSE
12	GTEx	Nerve Tibial	CCDC66	0.30	0.27	lasso	4	0.27	2.1e-19	-4.8	5.2	1.9e-07	-0.49	1.00	0.00	TRUE
13	GTEx	Pituitary	CCDC66	0.16	0.16	enet	31	0.12	6.8e-04	-4.8	8.8	1.2e-18	-0.66	0.04	0.85	FALSE
14	GTEx	Skin Sun Exposed Lower leg	FAM208A	0.06	0.04	lasso	2	0.03	2.0e-03	-7.5	7.5	9.3e-14	-0.69	0.16	0.58	FALSE
15	GTEx	Thyroid	CCDC66	0.22	0.26	lasso	4	0.26	5.9e-20	-4.8	5.5	3.1e-08	-0.55	1.00	0.00	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	ARF4	0.12	0.15	lasso	7	0.16	1.4e-19	4.5	5.7	1.0e-08	-0.02	1.00	0.00	TRUE
17	YFS	Blood	CCDC66	0.11	0.09	lasso	8	0.11	6.0e-34	-7.6	-8.7	4.1e-18	0.54	1.00	0.00	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCDC66	0.09	0.03	lasso	8	0.05	4.2e-11	-6.3	-9.2	4.7e-20	0.56	0.45	0.54	FALSE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	CCDC66	0.14	0.12	lasso	2	0.10	1.2e-06	-6.8	-6.8	1.4e-11	0.47	0.51	0.32	FALSE
20	The Cancer Genome Atlas	Glioblastoma Multiforme	CCDC66	0.19	0.02	enet	14	0.12	1.7e-04	2.0	-5.9	4.1e-09	0.21	0.04	0.06	FALSE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCDC66	0.05	0.05	blup	56	0.06	1.0e-07	-11.0	-11.0	3.6e-28	0.80	0.01	0.99	TRUE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C3orf63	0.03	0.01	enet	4	0.01	1.3e-02	-10.9	10.3	6.8e-25	-0.90	0.01	0.82	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC66	0.09	0.05	blup	56	0.06	5.3e-07	-7.7	-9.2	5.2e-20	0.69	0.53	0.47	FALSE
24	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ABHD6	0.09	0.07	lasso	3	0.03	4.3e-03	4.9	5.2	2.3e-07	-0.04	0.01	0.96	TRUE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCDC66	0.16	0.13	enet	12	0.16	3.1e-17	-7.6	-7.2	4.8e-13	0.38	1.00	0.00	FALSE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	CCDC66	0.05	0.06	blup	56	0.05	9.7e-07	-11.0	-10.9	7.1e-28	0.74	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CCDC66	0.03	0.03	blup	56	0.03	9.6e-05	-6.8	-8.6	1.2e-17	0.52	0.38	0.18	FALSE
28	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CCDC66	0.08	0.01	blup	56	0.07	7.2e-04	-7.6	-6.8	1.0e-11	0.34	0.12	0.07	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC66	0.15	0.10	enet	11	0.13	7.3e-14	-6.8	-7.5	7.1e-14	0.53	0.99	0.01	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	WNT5A	0.06	0.05	enet	5	0.05	1.0e-05	6.1	6.6	3.4e-11	-0.04	0.48	0.51	TRUE
31	The Cancer Genome Atlas	Rectum Adenocarcinoma	CCDC66	0.20	-0.01	lasso	3	0.00	3.0e-01	-6.8	-7.0	1.7e-12	0.51	0.02	0.35	TRUE
32	The Cancer Genome Atlas	Stomach Adenocarcinoma	CCDC66	0.05	0.01	blup	57	0.02	8.4e-03	-6.3	-8.5	2.2e-17	0.56	0.10	0.33	TRUE