TWAS hub - WNT5A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0850	0.0290	6.2e-04	0.014	0.017	-0.001	0.018	0.013	7.1e-03	3.0e-03	3.8e-01	0.0027	9.3e-03
2	GTEx	Esophagus Mucosa	0.2040	0.0640	5.9e-04	0.113	NA	0.050	NA	0.090	5.9e-08	NA	3.0e-04	NA	1.4e-06
3	GTEx	Pancreas	0.1950	0.0620	1.5e-03	0.205	NA	0.129	NA	0.182	4.5e-09	NA	4.3e-06	NA	3.9e-08
4	GTEx	Thyroid	0.0950	0.0390	8.8e-03	-0.003	NA	0.001	NA	-0.003	6.8e-01	NA	2.4e-01	NA	7.7e-01
5	TCGA	Prostate Adenocarcinoma	0.0633	0.0268	1.7e-05	0.055	0.047	0.047	NA	0.044	2.2e-06	1.1e-05	1.0e-05	NA	2.0e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	5
Lung FEV1/FVC ratio	3.4	17.1	48.7	-4.3	-3.2	-7.0	-2.9
Severe depression (siblings)	3.1	3.5	7.6	-2.4	-2.8	-1.2	-1.6
Medication: Gliclazide	2.9	3.3	7.2	2.4	0.7	2.7	-1.8
Asthma	2.7	5.4	11.7	3.3	1.0	3.4	1.8
Asthma (self-reported)	2.4	4.8	10.2	3.0	1.0	3.2	1.8
Hearing aid user	2.3	2.6	5.5	1.8	1.1	2.3	1.7
Tinnitus: Yes, now most or all of the time	2.3	2.7	6.5	0.9	0.8	2.4	2.6
Ever used hormone-replacement therapy (HRT)	2.2	2.8	5.8	-0.2	2.4	-2.0	2.0
Hair/balding pattern: Pattern 2	2.0	2.5	9.0	3.0	0.9	1.7	-0.1
Illnesses of father: Heart disease	2.0	2.7	8.2	1.6	1.6	0.1	2.9
Breastfed as a baby	1.9	2.4	5.5	2.0	2.4	1.5	0.5
Had major operations	1.9	2.2	6.0	1.4	-1.5	2.5	-0.7
Height	1.8	34.9	136.9	5.1	3.0	1.7	11.7
Respiratory disease	1.8	4.1	10.2	3.2	0.6	3.0	1.0
Diverticular disease/diverticulitis (self-reported)	1.8	2.2	5.7	0.9	2.4	0.7	1.9
Commuting to job workplace: Cycle	1.8	2.2	5.3	-1.9	-2.3	-1.1	-1.1
Crohns Disease (2017)	1.7	3.8	14.4	0.4	1.0	-1.8	3.8
Mean Putamen Volume	1.7	1.9	6.2	-0.7	-1.6	-0.4	-2.5
Hair/balding pattern: Pattern 3	1.7	2.6	7.6	-2.8	-0.4	-1.7	-1.5
Trunk predicted mass	1.7	9.5	35.0	2.4	1.4	2.2	5.9
Bipolar Disorder (2011)	1.6	1.5	4.6	-1.0	0.3	-2.1	-1.4
Qualifications: CSEs or equivalent	1.6	2.1	4.1	-1.9	0.1	-1.7	-2.0
Qualifications: None of the above	1.6	3.4	12.1	-3.5	-0.2	-2.0	-1.0
Trunk fat-free mass	1.6	9.3	34.9	2.3	1.4	2.1	5.9
Diabetes diagnosed by doctor	1.6	2.6	6.9	0.5	2.6	2.4	0.7
Average weekly fortified wine intake	1.5	1.8	4.2	-0.8	-1.9	-2.0	0.5
Had menopause	1.5	1.9	3.6	-1.1	1.9	-1.3	1.8
Pulse wave Arterial Stiffness index	1.5	1.8	7.6	0.6	1.0	0.2	2.8
Eye problems/disorders: Cataract	1.5	1.8	5.2	1.4	2.3	1.1	-0.7
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	6.5	-1.2	-0.6	-0.3	2.6
Arm fat-free mass (right)	1.4	7.4	28.0	1.8	1.2	2.1	5.3
Comparative height size at age 10	1.4	7.9	30.0	2.1	2.0	-1.0	5.5
Whole body fat-free mass	1.4	7.8	29.8	1.9	1.2	2.1	5.5
Whole body water mass	1.4	7.8	30.7	1.7	1.3	1.9	5.5
Arm predicted mass (left)	1.4	7.0	27.8	1.6	1.1	1.8	5.3
Townsend deprivation index at recruitment	1.3	1.9	6.9	-0.4	-2.6	0.2	-1.5
Birth weight	1.3	2.9	8.8	1.4	0.8	1.8	3.0
Arm predicted mass (right)	1.3	6.6	25.7	1.6	1.1	1.9	5.1
Arm fat-free mass (left)	1.3	6.6	26.0	1.7	1.0	1.8	5.1
Supplements: Zinc	1.2	1.3	2.7	1.5	0.4	1.1	1.6
Standing height	1.2	12.2	44.0	3.6	1.3	1.4	6.6
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.4	1.2	0.6	1.8	1.5
Exposure to tobacco smoke outside home	1.2	1.6	4.4	-2.1	-0.6	-1.1	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.7	1.1	1.7	0.9	1.5
Health satisfaction	1.2	1.6	7.1	0.3	0.8	-0.1	2.7
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	4.6	-0.2	-2.1	0.1	-1.6
Basal metabolic rate	1.2	6.8	27.1	1.3	1.4	1.8	5.2
Ever had prostate specific antigen (PSA) test	1.2	1.4	4.1	0.9	-1.5	2.0	-0.2
Leg fat-free mass (left)	1.1	5.8	21.9	1.3	1.4	1.8	4.7
Leg predicted mass (left)	1.1	5.7	21.7	1.3	1.3	1.9	4.7
Worrier / anxious feelings	1.1	2.1	6.5	-2.5	-0.9	-1.7	-0.6
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.7	-1.1	-1.5	-0.7	1.6
Blood clot in the leg (DVT)	1.1	1.4	5.5	-0.3	-1.0	-2.4	0.8
Chronic bronchitis/emphysema (mother)	1.1	1.3	4.6	-2.1	0.2	-1.2	-0.4
Ever had bowel cancer screening	1.1	1.2	4.2	-1.4	0.4	-2.0	-0.1
Qualifications: nursing, teaching	1.1	1.7	5.9	2.4	0.3	1.0	1.3
Medication: Paracetamol	1.1	1.7	3.8	-1.9	1.0	-1.8	0.9
Crohns Disease (2012)	1.0	1.5	4.4	0.3	0.6	-1.7	2.1
Diabetes (mother)	1.0	1.2	3.3	0.3	1.7	-0.1	1.8
Sitting height	1.0	7.1	15.5	3.3	-0.7	2.9	3.9
Prospective memory result	1.0	1.2	3.6	-1.1	-0.1	-1.0	1.9
Medication: Paracetamol	1.0	1.6	5.0	-2.2	0.2	-1.6	0.7
Number of full brothers	1.0	1.3	3.6	1.9	1.4	1.0	0.4
Pulse wave peak to peak time	1.0	1.2	5.0	-0.6	-0.9	-0.2	-2.2
Eye problems/disorders: None of the above	1.0	1.2	2.3	-0.9	-1.5	-1.5	0.8
Medication: Omeprazole	1.0	1.2	3.0	-1.7	0.2	-1.4	-0.9
Suffer from ‘nerves’	1.0	1.6	3.5	-1.3	-1.0	-1.9	-1.3
Chest pain or discomfort	1.0	1.5	5.8	1.1	0.6	2.4	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	2.5	-1.6	0.0	-1.2	-1.3
Leg fat-free mass (right)	1.0	5.4	22.4	1.2	1.0	1.6	4.7
Leg predicted mass (right)	1.0	5.5	23.1	1.2	1.1	1.4	4.8
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.7	-1.5	0.7	-1.6	-0.7
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	4.8	-0.2	-0.8	-2.2	1.1
Alzheimer’s Disease (in mother)	0.9	1.1	4.7	0.8	2.2	-0.1	-0.2
Fasting Glucose	0.9	1.1	3.5	0.5	-0.3	-1.9	-1.2
Type 2 Diabetes (T2D) (2018)	0.9	1.7	5.6	-0.4	2.4	1.3	1.1
Mouth/teeth dental problems	0.9	1.4	3.8	0.3	-0.7	1.9	-1.6
Pulse rate	0.9	1.5	3.5	-0.7	0.9	1.9	1.6
Knee pain experienced in last month	0.9	1.4	3.2	-1.8	1.0	-1.5	0.8
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	4.0	-2.0	-0.4	-1.7	0.2
Osteoarthritis (self-reported)	0.9	1.2	4.1	-0.8	-2.0	-0.1	1.1
Illnesses of father: None of the above (group 1)	0.9	1.1	3.0	-1.4	-1.7	-0.4	-0.5
High cholesterol (Self-reported)	0.9	1.5	3.0	0.0	1.7	1.6	1.5
Basal cell carcinoma (self-reported)	0.9	1.1	3.5	0.8	-0.0	1.1	1.9
Age at First Birth	0.8	1.1	2.5	1.0	1.0	1.6	1.0
Lupus	0.8	1.2	3.1	0.4	1.6	-1.8	-0.4
Hand grip strength (left)	0.8	2.1	6.4	2.5	1.0	1.2	1.2
Multivitamins +/- minerals	0.8	1.1	3.5	1.2	-0.4	1.9	-0.1
Had other major operations	0.8	0.9	2.2	1.3	0.7	0.3	1.5
Forced vital capacity (FVC)	0.8	3.1	6.3	2.0	1.0	2.5	2.0
Diabetes (self-reported)	0.8	1.2	3.4	0.0	1.8	1.7	0.1
Noisy workplace	0.8	1.0	3.5	-1.2	-0.1	-0.2	1.9
Illnesses of mother	0.8	1.0	2.5	0.6	-1.6	1.1	-1.1
Tense / ‘highly strung’	0.8	1.3	3.7	-1.9	1.2	-1.1	0.5
Medication: Amlodipine	0.8	1.1	3.6	-1.9	0.1	-1.3	-0.4
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.5	1.2	1.6	0.1	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.0	1.4	-0.3	1.4	-0.8
Number of operations (self-reported)	0.8	1.2	2.6	1.1	-0.9	1.6	1.1
Pack years of smoking	0.8	1.2	3.4	-1.8	1.5	-0.6	-0.2
Prostate Cancer	0.7	0.9	2.4	-1.6	0.4	-1.4	0.2
LDL Cholesterol	0.7	1.2	2.5	1.6	1.4	1.2	-0.2
Cardiovascular Disease	0.7	2.4	6.0	1.1	1.2	2.5	1.9
Medication for hormone replacement therapy	0.7	0.8	2.8	-0.2	1.1	-0.1	1.7
Pack years adult smoking proportion	0.7	1.0	2.5	-1.5	1.6	-0.5	-0.1
Stomach or abdominal pain in last month	0.7	0.9	1.6	-1.2	-1.3	0.3	-1.2
Medication: Atenolol	0.7	0.9	2.8	-1.2	-1.7	0.2	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.7	-1.2	-1.3	0.9	-1.3
Heart attack	0.7	0.9	2.2	-0.7	0.9	-1.5	-1.0
Weight	0.7	3.5	13.6	0.1	1.5	1.2	3.7
Alcohol intake versus 10 years previously	0.7	1.0	2.6	-1.4	-0.4	-1.6	-0.6
Lung cancer (father)	0.7	0.9	2.7	-0.8	1.0	0.1	-1.6
Peak expiratory flow (PEF)	0.7	1.7	5.6	2.4	-1.0	1.3	0.4
Age at first live birth	0.7	1.2	3.5	0.5	1.9	-0.4	1.4
Alcohol intake frequency.	0.7	1.6	3.7	-1.9	0.5	-1.7	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	5.4	1.4	0.5	0.0	2.3
Commuting to job workplace: Walk	0.7	0.8	1.7	-0.8	-0.2	-1.3	-1.2
Osteoporosis (self-reported)	0.7	0.9	2.9	0.9	1.7	-0.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	3.3	-1.8	0.4	-1.4	-1.5
Ever taken oral contraceptive pill	0.7	0.8	3.0	0.7	-0.5	1.7	-0.3
Alcohol drinker status: Never	0.7	0.8	3.5	-1.9	0.4	-0.6	0.2
Age started oral contraceptive pill	0.7	0.9	3.0	0.8	1.7	0.4	0.8
Unable to work because of sickness or disability	0.7	0.9	2.9	0.1	1.3	-0.2	1.7
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.3	-0.5	1.0	-1.5	-1.0
Irritable Bowel Disease (IBD)	0.6	1.5	4.7	1.0	0.7	-1.1	2.2
Body Mass Index (BMI) (2010)	0.6	0.8	3.0	-0.1	-0.3	0.9	-1.7
HDL Cholesterol	0.6	1.0	4.9	0.2	-2.2	0.1	-0.2
Triglycerides	0.6	1.0	3.7	-0.3	1.9	-0.5	-1.0
Hypothyroidism (self reported)	0.6	1.5	6.2	0.9	-0.4	2.5	-0.3
Chronotype (morning person)	0.6	1.4	3.6	1.9	1.5	0.7	-0.7
Hearing difficulty/problems: Yes	0.6	0.8	4.2	-0.1	0.1	0.0	2.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	2.7	0.0	-0.8	1.6	-0.4
Hand grip strength (right)	0.6	1.7	3.6	1.9	1.3	-0.2	1.9
Nervous feelings	0.6	1.1	4.1	-1.1	-2.0	0.0	0.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.5	1.2	-0.3	1.6	-0.4
Neuroticism score	0.6	1.3	3.4	-1.9	-0.9	-1.5	0.0
Medication: Cholesterol lowering	0.6	0.9	3.1	0.5	1.8	0.9	-0.0
Pulse wave reflection index	0.6	0.8	1.6	0.9	1.2	-0.4	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.3	1.5	-1.2	0.2	-0.2
Pulse rate, automated reading	0.6	1.9	9.2	0.1	-0.6	3.0	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.8	-1.2	0.6	-1.3	0.2
Number of self-reported non-cancer illnesses	0.6	1.0	3.2	0.8	0.3	1.8	0.9
Average weekly champagne plus white wine intake	0.6	0.8	2.7	-0.2	-1.6	-0.6	0.9
Mother’s age at death	0.6	0.8	1.3	-0.4	1.1	1.1	-1.1
Medication: Lisinopril	0.6	0.8	2.1	0.9	1.5	0.4	1.0
Alzheimer’s Disease (in father)	0.5	0.5	1.4	-1.2	0.2	-1.0	0.5
Coronary Artery Disease (CAD)	0.5	0.5	1.3	0.7	1.1	0.3	-0.9
Waist Hip Ratio (WHR)	0.5	2.1	5.4	0.3	1.9	-1.1	2.3
Lung FVC	0.5	2.5	7.3	-0.9	1.1	2.7	-1.8
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.1	-1.5	-0.6	-0.8	0.4
Vitamin and mineral supplements	0.5	0.7	2.4	-0.8	-0.2	-1.6	-0.4
Current tobacco smoking	0.5	0.9	2.1	-0.4	1.4	-0.9	1.1
Age when periods started (menarche)	0.5	1.1	2.0	1.4	1.4	0.5	1.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.7	0.2	0.0	-1.3	1.0
Serious illness, injury or assault to yourself	0.5	0.7	2.6	-0.6	0.6	0.3	1.6
Supplements: Glucosamine	0.5	0.7	2.2	-1.5	-1.0	-0.4	0.0
Chronic bronchitis/emphysema (father)	0.5	0.6	2.3	0.5	1.5	0.2	-0.7
Waist circumference	0.5	1.7	4.3	-0.5	2.1	0.5	1.9
Impedance of arm (right)	0.5	2.1	5.7	-0.6	-0.0	-2.2	-2.4
Hip circumference	0.5	2.0	3.4	0.6	1.7	1.9	1.8
Father’s age at death	0.5	0.7	1.8	0.9	-0.9	0.2	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.9	-1.4	-0.1	0.9	-0.5
Loud music exposure frequency	0.5	0.5	1.5	-0.2	-1.0	1.2	-0.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	4.1	0.6	0.0	2.0	-0.7
High blood pressure (siblings)	0.5	0.7	1.7	-1.1	0.4	-0.7	1.3
Comparative body size at age 10	0.5	1.4	5.6	-0.7	-2.4	-1.0	-0.3
Wheeze or whistling in the chest in last year	0.5	0.9	4.3	0.1	0.0	2.1	-0.1
Number of children fathered	0.5	0.6	1.9	-1.4	-0.6	-0.0	-0.9
Neck or shoulder pain in last month	0.5	0.7	3.0	-0.4	-1.7	0.5	0.4
Overall health rating	0.5	1.1	3.4	-1.8	0.0	-0.4	1.4
Medication: Aspirin	0.5	0.7	2.2	0.2	1.5	1.0	-0.1
Medication: Aspirin	0.5	0.6	1.6	0.0	1.3	1.3	-0.2
Smoking status: Current	0.5	0.8	1.4	-0.4	1.1	-1.2	1.0
Miserableness	0.5	0.8	1.8	-1.3	-0.5	-0.8	1.3
Eye problems/disorders: Glaucoma	0.5	0.6	2.1	-0.5	-1.4	-0.2	-0.8
Pain experienced in last month	0.5	0.8	1.8	0.7	1.1	-0.5	-1.3
Impedance of whole body	0.5	2.4	7.5	-0.8	-0.4	-2.0	-2.7
Schizophrenia vs Biploar Disorder	0.4	0.5	1.5	1.2	0.7	0.6	-0.5
Alzheimer’s Disease (including proxy)	0.4	0.6	2.6	-0.7	1.6	-0.2	0.0
Breast Cancer	0.4	0.9	2.8	1.3	0.3	1.7	0.0
Primary Biliary Cirrhosis	0.4	0.6	1.0	1.0	-0.6	-0.8	-1.0
Allergy or Eczema	0.4	1.0	1.7	1.3	1.2	0.7	1.2
Average weekly spirits intake	0.4	0.5	1.7	1.3	-0.6	-0.2	-0.8
Sensitivity / hurt feelings	0.4	0.7	2.7	-0.8	-1.6	0.1	-0.3
Ever had hysterectomy (womb removed)	0.4	0.5	2.0	0.4	-0.4	0.4	1.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.7	-0.2	1.3	0.0	-0.5
Medication: Metformin	0.4	0.6	1.8	-0.2	1.0	1.4	-0.2
Diabetes (father)	0.4	0.5	1.7	-0.9	-1.3	-0.2	0.1
Fed-up feelings	0.4	0.8	2.1	-1.2	-1.4	-0.4	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.3	-0.8	0.9	-1.5	0.7
High blood pressure	0.4	1.2	3.7	0.7	1.9	1.2	0.6
Trunk fat mass	0.4	1.6	3.6	-1.1	1.7	0.5	1.9
Number of incorrect matches in round	0.4	0.6	1.7	-0.2	1.2	1.3	0.3
Financial difficulties in last 2 years	0.4	0.5	1.1	0.9	-1.0	0.0	-0.7
Pain all over the body in last month	0.4	0.4	0.8	-0.9	-0.9	-0.7	0.1
Medication: Simvastatin	0.4	0.6	1.4	-0.5	1.2	1.1	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.4	0.9	-0.3	-0.6	1.2
Depression (self-reported)	0.4	0.5	1.3	-0.1	0.4	0.9	1.1
Impedance of arm (left)	0.4	1.7	5.2	-0.2	0.3	-1.7	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.7	0.2	0.1	-0.3	1.7
Birth weight of first child	0.4	0.7	2.5	0.7	0.5	0.7	1.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.5	0.5	-1.1	1.2	-0.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.6	0.7	0.1	-1.3	0.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.9	0.7	-1.4	-0.3	1.1
Gout (self-reported)	0.4	0.6	1.4	-0.3	-0.8	-0.9	1.2
Forced vital capacity (FVC), Best measure	0.4	1.3	5.5	0.8	0.0	2.3	0.7
Medication for pain relief, constipation, heartburn	0.4	0.8	1.5	0.8	-1.1	0.7	-1.2
Migraine (self-reported)	0.4	0.5	1.4	-0.3	-1.2	0.4	-1.0
Mean time to correctly identify matches	0.4	0.7	1.8	0.4	1.3	-0.4	1.3
Heart disease (mother)	0.4	0.5	0.7	-0.7	0.8	-0.8	0.7
Whole body fat mass	0.4	1.5	3.1	-1.4	1.4	0.6	1.8
Leg fat mass (right)	0.4	1.5	2.3	-1.3	1.4	1.2	1.5
Leg pain on walking	0.4	0.6	2.5	-0.5	-0.0	0.1	1.6
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.4	-0.8	0.2	-0.0	1.2
Hypertension (Self-reported)	0.4	1.2	3.2	0.5	1.8	1.3	0.8
Illnesses of siblings: Diabetes	0.4	0.5	1.4	0.7	1.2	-0.2	0.6
Arm fat percentage (left)	0.4	1.4	5.4	-2.3	1.2	-0.1	-0.2
Medication for cholesterol	0.4	0.6	1.9	0.7	-0.1	-0.8	-1.4
Arm fat mass (left)	0.4	1.4	3.5	-1.2	1.5	0.3	1.9
Guilty feelings	0.4	0.6	2.0	-1.4	-0.1	-0.5	-1.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	1.0	-0.1	1.0	0.6
Medication: Atorvastatin	0.4	0.5	1.1	0.5	0.9	-0.6	-1.1
Average weekly beer plus cider intake	0.4	0.5	1.4	-0.0	-0.8	0.7	-1.2
Irritability	0.4	0.7	1.8	-0.9	0.5	-1.3	0.8
Fractured/broken bones in last 5 years	0.4	0.5	1.9	0.1	-0.7	-1.4	-0.3
Myopia	0.4	0.6	1.6	0.0	0.1	-1.3	-1.1
Leg fat mass (left)	0.4	1.6	2.9	-1.3	1.3	1.2	1.7
Depressed Affect (Nagel 2018)	0.3	0.6	1.0	-0.7	-0.8	-1.0	0.9
Reaction Time	0.3	0.6	1.8	0.1	1.3	-0.1	1.0
HbA1C	0.3	0.3	0.9	-0.9	-1.0	-0.1	0.1
Neuroticism (2016)	0.3	0.5	1.3	-1.1	-0.7	-0.4	-0.8
BMI	0.3	1.7	4.0	-1.2	2.0	1.4	1.0
Neuroticism	0.3	0.7	2.1	-1.4	-0.7	-1.0	-0.2
Relative age of first facial hair	0.3	0.6	2.4	1.6	-0.0	-0.3	-0.6
Systolic blood pressure, automated reading	0.3	1.0	2.6	0.0	1.6	-0.8	1.2
Angina	0.3	0.4	1.2	-1.1	0.7	-0.2	0.3
Medication: Co-codamol	0.3	0.3	1.0	-0.5	-0.4	-0.5	1.0
Trunk fat percentage	0.3	1.1	3.2	-1.8	1.5	-0.3	0.5
Maternal smoking around birth	0.3	0.4	0.7	-0.9	-0.0	0.7	0.8
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.6	1.3	0.6	0.7	0.7
Medication: Levothyroxine sodium	0.3	0.5	1.4	-0.4	0.6	1.2	-0.7
Impedance of leg (left)	0.3	1.5	4.5	-0.7	-0.4	-1.6	-2.1
Alcohol usually taken with meals	0.3	0.4	1.4	0.3	0.1	-0.8	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.0	-0.4	1.1	-1.4	0.6
Allergy	0.3	0.7	2.7	-1.7	0.3	-0.5	-0.6
Arm fat percentage (right)	0.3	1.3	5.5	-2.3	1.0	-0.2	-0.2
Number of live births	0.3	0.4	1.2	-0.5	0.5	0.3	-1.1
Arm fat mass (right)	0.3	1.4	3.2	-1.4	1.4	0.3	1.8
Length of working week for main job	0.3	0.4	0.9	0.9	0.9	0.3	0.3
Headache pain in last month	0.3	0.4	1.3	-0.1	0.9	0.3	1.1
Body fat percentage	0.3	1.3	4.3	-2.1	1.4	-0.0	0.1
Leg fat percentage (right)	0.3	1.1	2.8	-1.7	1.4	0.9	0.1
Medication: Blood pressure	0.3	0.6	1.3	-0.8	0.9	-0.2	-1.2
Angina (self-reported)	0.3	0.4	1.5	-1.2	0.5	-0.2	0.6
Medication: Ibuprofen	0.3	0.4	0.7	0.9	-0.6	-0.5	0.7
Medication: Seretide 50 evohaler	0.3	0.3	1.0	1.0	-0.0	0.5	-0.5
Age at last live birth	0.3	0.5	1.9	-0.1	1.4	-0.2	0.7
Supplements: Vitamin C	0.3	0.4	0.6	-0.7	-0.6	-0.7	0.6
Mood swings	0.3	0.6	1.6	-1.3	-0.6	-0.8	0.6
Long-standing illness, disability or infirmity	0.3	0.5	1.4	0.4	-0.5	1.2	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	0.3	0.4	0.9	-0.5
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.8	-0.1	-0.9	-0.4	0.9
Medication: Bendroflumethiazide	0.3	0.5	1.6	-0.2	-0.3	0.8	-1.3
Illnesses of father: High blood pressure	0.3	0.4	1.0	0.6	1.0	-0.3	-0.6
Leg fat percentage (left)	0.3	1.2	3.7	-1.9	1.3	0.7	0.3
Risk taking	0.3	0.5	1.3	-1.2	0.0	-1.0	0.0
Diastolic blood pressure, automated reading	0.3	0.9	2.1	-0.6	1.4	-0.5	1.4
Supplements: Calcium	0.3	0.3	0.8	0.9	-0.5	0.7	0.3
Heart disease (siblings)	0.3	0.4	1.0	-0.0	1.0	0.8	0.5
Bipolar Disorder (2018)	0.2	0.4	1.0	0.3	-0.2	-1.0	0.8
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.4	1.5	-0.5	0.4	-0.2
Neuroticism (Nagel 2018)	0.2	0.4	0.8	-0.9	-0.8	-0.6	0.1
Schizophrenia (2018)	0.2	0.3	0.7	0.7	0.8	0.7	0.1
Worry (Nagel 2018)	0.2	0.4	1.3	-1.1	-0.3	-0.5	-0.5
Ulcerative Colitis (UC)	0.2	0.4	1.6	1.3	0.5	-0.2	-0.1
Major Depression (MDD)	0.2	0.2	0.8	-0.4	-0.3	0.9	0.4
Rheumatoid Arthritis	0.2	0.3	1.0	0.2	-0.1	0.8	1.0
Blood Eosinophil Count	0.2	1.6	4.9	1.7	-0.1	2.2	0.1
Blood Platelet Count	0.2	2.6	11.2	1.3	-0.3	3.3	0.2
Blood White Count	0.2	1.4	5.0	1.0	-1.0	2.2	-0.5
Heel T-Score	0.2	1.3	3.7	-1.9	-1.1	-1.1	-0.7
Systolic Blood Pressure	0.2	1.1	2.7	1.6	0.9	-1.2	0.6
Smoking Status	0.2	0.5	1.5	-1.0	0.3	-1.2	-0.2
Tanning	0.2	3.0	7.8	-2.8	-1.5	-1.2	-1.9
Number of treatments/medications taken	0.2	0.3	1.1	-0.2	0.5	1.1	0.5
Impedance of leg (right)	0.2	1.1	4.7	-0.1	-0.0	-1.0	-2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.4	0.6	-0.7	0.7	0.6
Relative age voice broke	0.2	0.4	1.1	0.6	1.1	-0.5	0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.8	0.5	0.9	0.4	0.3
Body mass index (BMI)	0.2	1.0	2.7	-1.6	1.1	0.5	0.8
Past tobacco smoking	0.2	0.4	1.3	-0.2	1.2	-0.0	0.6
Medication: Ramipril	0.2	0.2	0.5	0.0	0.7	0.7	-0.4
Fluid intelligence score	0.2	0.4	0.8	0.9	-0.4	0.9	0.4
Illnesses of siblings	0.2	0.2	0.6	0.4	-0.8	-0.3	-0.6
Time employed in main current job	0.2	0.2	0.4	0.6	0.6	-0.2	0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.3	1.3	-0.0	0.5	1.5
Happiness	0.2	0.3	0.6	-0.4	-0.8	-0.2	0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.6	0.3	-1.3	0.8	-0.5
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	0.2	-0.5	-0.8	0.7
Medication: Lansoprazole	0.2	0.2	0.6	0.1	-0.1	-0.8	-0.6
Exposure to tobacco smoke at home	0.2	0.2	0.6	0.0	0.8	-0.1	0.5
Hair/balding pattern: Pattern 4	0.2	0.5	2.1	-0.0	-0.4	-1.4	0.2
Worry too long after embarrassment	0.2	0.4	1.3	-0.6	-0.7	-0.3	-1.1
Qualifications: College or University degree	0.2	0.8	1.7	0.7	-1.3	1.2	0.4
Emphysema/chronic bronchitis	0.2	0.2	0.4	0.6	-0.3	-0.6	-0.1
Medication: Allopurinol	0.2	0.3	0.9	-0.2	-0.3	-0.7	0.9
Number of full sisters	0.2	0.3	1.0	-0.6	-1.0	-0.3	-0.1
Smoking status: Previous	0.2	0.2	0.4	0.2	-0.7	0.4	-0.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.6	-0.5	-0.4	0.0	-0.8
Breast cancer (self-reported)	0.2	0.2	0.7	-0.4	0.0	-0.9	-0.6
Wears glasses or contact lenses	0.2	0.3	0.6	0.2	-0.8	-0.7	-0.4
Commuting to job workplace: Public transport	0.2	0.2	0.7	0.0	-0.8	0.3	-0.6
Medication: Blood pressure	0.2	0.3	0.7	0.7	0.1	0.9	0.6
Vascular/heart problems diagnosed by doctor	0.2	0.7	2.6	-0.1	-1.6	-0.7	-0.4
Cholesterol lowering medication	0.2	0.3	1.4	-0.1	1.2	-0.2	0.1
Alcohol drinker status: Previous	0.2	0.2	0.7	-0.1	-0.4	0.5	0.9
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	0.8	0.5	-0.1	0.6
Depression (Nagel 2018)	0.1	0.1	0.3	-0.2	-0.3	0.5	0.6
Schizophrenia (2014)	0.1	0.2	0.5	0.5	0.7	0.2	0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.4	0.4	-0.5	0.6	-0.0
Ulcerative Colitis	0.1	0.1	0.5	0.7	-0.0	0.3	-0.1
Taking other prescription medications	0.1	0.1	0.2	0.2	0.4	0.3	0.4
High blood pressure (mother)	0.1	0.1	0.3	0.0	0.3	0.1	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	-0.4	0.6	-0.1	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.9	-0.1	-0.9	0.4	0.3
Glaucoma (self-reported)	0.1	0.1	0.3	0.5	-0.3	0.6	-0.2
Shortness of breath walking on level ground	0.1	0.1	0.2	0.5	-0.2	-0.2	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	-0.3	-0.5	0.2	-0.7
Family relationship satisfaction	0.1	0.1	0.4	-0.7	0.1	0.4	-0.2
Average weekly red wine intake	0.1	0.2	0.6	0.8	0.4	-0.1	0.6
Loneliness, isolation	0.1	0.1	0.3	-0.2	-0.3	-0.5	0.2
Friendships satisfaction	0.1	0.1	0.2	0.4	0.1	-0.5	0.3
Back pain experienced in last month	0.1	0.2	0.5	0.5	-0.3	0.7	0.3
Mineral and other dietary supplements	0.1	0.1	0.5	0.1	0.1	-0.3	-0.7
Ever depressed for a whole week	0.1	0.1	0.6	0.0	0.1	0.1	0.8
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.4	0.1	-0.6	0.3	0.1
Ovarian Cancer	0.0	0.0	0.1	-0.1	0.4	-0.2	-0.0
Blood Red Count	0.0	0.2	0.8	-0.0	0.0	-0.9	0.5
Hair Pigment	0.0	0.6	1.7	-0.7	-0.5	1.3	-0.7
Hearing difficulty/problems with background noise	0.0	0.0	0.1	0.1	-0.3	0.2	0.2
Falls in the last year	0.0	0.0	0.1	-0.3	0.2	0.1	-0.1
Financial situation satisfaction	0.0	0.0	0.1	0.2	0.0	0.3	-0.3
Ever smoked	0.0	0.1	0.2	0.4	-0.3	0.3	-0.1

Hub : Genes

WNT5A

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Trait associations