Best TWAS P=4.37e-13 · Best GWAS P=4.38e-19 conditioned to 0.0018
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | ARHGAP24 | 0.24 | 0.13 | enet | 8 | 0.14 | 2.2e-08 | -4.93 | -6.0 | 2.5e-09 | 0.01 | 0.01 | 0.99 | FALSE |
2 | GTEx | Artery Aorta | RP13-514E23.2 | 0.26 | 0.09 | lasso | 6 | 0.10 | 2.2e-06 | -5.71 | -6.0 | 1.6e-09 | 0.02 | 0.00 | 1.00 | TRUE |
3 | GTEx | Artery Tibial | ARHGAP24 | 0.26 | 0.19 | enet | 14 | 0.21 | 2.7e-16 | -5.71 | -5.6 | 1.9e-08 | -0.01 | 0.00 | 1.00 | FALSE |
4 | GTEx | Artery Tibial | RP13-514E23.2 | 0.22 | 0.16 | enet | 10 | 0.18 | 1.2e-13 | -5.71 | -5.7 | 1.0e-08 | 0.01 | 0.00 | 1.00 | FALSE |
5 | GTEx | Nerve Tibial | RP13-514E23.2 | 0.17 | 0.00 | lasso | 6 | 0.00 | 1.9e-01 | -5.45 | -5.5 | 4.6e-08 | 0.05 | 0.04 | 0.50 | FALSE |
6 | METSIM | Adipose | HSD17B13 | 0.20 | 0.10 | bslmm | 416 | 0.12 | 7.3e-18 | 4.21 | -7.0 | 3.1e-12 | 0.24 | 1.00 | 0.00 | TRUE |
7 | The Cancer Genome Atlas | Colon Adenocarcinoma | IBSP | 0.09 | 0.02 | enet | 15 | 0.07 | 9.4e-05 | 0.05 | 5.9 | 4.2e-09 | -0.62 | 0.02 | 0.63 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | IBSP | 0.08 | 0.00 | blup | 77 | 0.00 | 1.6e-01 | -2.89 | 6.5 | 9.8e-11 | -0.71 | 0.04 | 0.12 | TRUE |
9 | The Cancer Genome Atlas | Lung Adenocarcinoma | DMP1 | 0.05 | 0.04 | enet | 4 | 0.04 | 2.1e-05 | -5.01 | 7.2 | 4.4e-13 | -0.70 | 0.28 | 0.50 | TRUE |
10 | The Cancer Genome Atlas | Lung Adenocarcinoma | IBSP | 0.06 | 0.01 | blup | 78 | 0.03 | 7.7e-05 | -7.42 | 6.0 | 1.8e-09 | -0.75 | 0.10 | 0.71 | FALSE |