TWAS hub - DMP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Head and Neck Squamous Cell Carcinoma	0.0323	0.0178	4.1e-03	0.02	0.023	0.020	NA	0.016	2.3e-03	1.3e-03	2.5e-03	NA	5.9e-03
2	TCGA	Lung Adenocarcinoma	0.0463	0.0248	3.7e-04	0.04	0.032	0.039	NA	0.038	1.5e-05	1.0e-04	2.1e-05	NA	2.4e-05
3	TCGA	Lung Squamous Cell Carcinoma	0.0930	0.0427	1.8e-06	0.04	0.049	0.038	NA	0.029	2.1e-05	2.6e-06	3.2e-05	NA	2.6e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Osteoarthritis (self-reported)	5.8	7.6	10.2	3.2	2.5	2.5
Prospective memory result	5.4	6.6	8.0	2.5	2.4	2.8
Heel T-Score	5.3	41.8	79.2	-3.2	-8.9	-6.0
Diverticular disease/diverticulitis (self-reported)	4.4	5.2	5.6	2.1	2.3	2.4
Medication: Seretide 50 evohaler	4.1	4.7	6.2	-1.7	-2.5	-2.3
Ever used hormone-replacement therapy (HRT)	3.9	4.9	5.0	2.2	2.2	2.2
Tinnitus: Yes, now most or all of the time	3.9	4.6	5.1	2.1	2.3	2.1
Medication: Bendroflumethiazide	3.9	5.9	7.3	2.4	2.1	2.7
Pulse wave Arterial Stiffness index	3.5	4.1	6.0	2.4	1.7	1.8
Type 2 Diabetes (T2D) (2012)	3.3	3.8	6.2	-2.5	-0.1	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	3.3	7.5	12.5	-1.7	-3.5	-2.7
Sitting height	3.1	22.2	63.7	0.6	8.0	1.6
Medication: Allopurinol	2.9	3.9	5.0	-2.2	-1.7	-2.0
Pulse wave peak to peak time	2.8	3.2	5.7	-2.4	-1.1	-1.7
Ever taken oral contraceptive pill	2.8	3.1	3.6	1.6	1.8	1.9
Heel bone mineral density (BMD) T-score, automated (left)	2.7	6.1	10.7	-1.4	-3.3	-2.4
Pulse wave reflection index	2.6	3.2	5.5	2.3	1.4	1.4
Gout (self-reported)	2.3	3.1	3.6	-1.7	-1.9	-1.6
Pain experienced in last month	2.3	3.9	7.5	2.7	0.8	1.9
Lung FVC	2.2	11.1	13.7	-3.7	-2.9	-3.3
Crohns Disease (2012)	2.0	3.1	4.2	-2.1	-1.2	-2.0
Qualifications: O levels/GCSEs or equivalent	2.0	3.2	5.0	-1.7	-1.4	-2.2
Medication: Ibuprofen	2.0	2.4	3.1	-1.5	-1.4	-1.8
Alcohol drinker status: Previous	2.0	2.2	3.2	1.8	0.7	1.7
Alzheimer’s Disease (in father)	1.9	2.0	3.8	1.1	2.0	1.0
Height	1.9	36.7	104.0	1.3	10.2	2.1
Serious illness, injury or assault to yourself	1.9	2.3	2.5	1.6	1.4	1.6
Fasting Glucose	1.8	2.2	3.0	-1.7	-1.0	-1.6
Standing height	1.8	18.0	52.4	0.6	7.2	1.1
Age at last live birth	1.8	2.7	3.7	-1.9	-1.4	-1.5
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	4.2	1.9	0.7	2.1
Fractured/broken bones in last 5 years	1.8	2.3	2.9	1.3	1.7	1.5
Neuroticism (2016)	1.7	2.4	4.1	1.0	2.0	1.4
Medication: Atorvastatin	1.7	2.0	2.7	-1.5	-1.0	-1.6
Commuting to job workplace: Car/motor vehicle	1.6	1.9	3.7	0.8	1.9	1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	2.6	-1.6	-1.1	-1.1
Mouth/teeth dental problems: Dentures	1.5	2.6	3.2	-1.8	-1.3	-1.7
Medication: Lansoprazole	1.5	1.7	3.2	-1.8	-0.5	-1.2
Headache pain in last month	1.5	2.6	5.7	-0.8	-2.4	-1.2
Neck or shoulder pain in last month	1.5	2.1	3.6	-1.9	-1.1	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	2.7	-1.6	-0.9	-1.3
Medication: Co-codamol	1.4	1.7	2.4	1.4	0.8	1.6
Had other major operations	1.4	1.7	3.1	0.9	1.0	1.8
Trunk fat-free mass	1.4	7.9	22.7	0.3	4.8	1.0
Trunk predicted mass	1.4	7.8	22.1	0.3	4.7	1.0
Pain type(s) experienced in last month: Hip pain	1.4	1.8	2.4	1.1	1.6	1.3
Heart attack/myocardial infarction (self-reported)	1.4	1.9	3.9	-0.8	-2.0	-1.0
Hand grip strength (right)	1.3	3.6	5.9	-2.4	-0.4	-2.2
Heart attack	1.3	1.7	4.0	-0.6	-2.0	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	2.1	-1.3	-1.2	-1.5
Arm fat-free mass (right)	1.3	6.4	18.4	0.2	4.3	0.9
Osteoporosis (self-reported)	1.3	1.6	1.7	-1.3	-1.2	-1.3
HDL Cholesterol	1.2	2.1	3.4	1.8	0.6	1.6
Frequency of depressed mood in last 2 weeks	1.2	1.6	4.6	-0.5	-2.1	-0.3
Relative age voice broke	1.2	1.9	3.0	-1.6	-0.3	-1.7
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	2.7	-1.4	-1.6	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	2.0	-1.4	-0.3	-1.4
Medication: Amlodipine	1.2	1.7	2.4	-1.2	-1.6	-1.1
Arm predicted mass (right)	1.2	6.0	17.6	-0.1	4.2	0.6
Comparative height size at age 10	1.2	6.5	18.2	0.3	4.3	1.1
Whole body fat-free mass	1.2	6.7	19.3	0.2	4.4	0.9
Commuting to job workplace: Walk	1.2	1.2	1.9	1.2	-0.6	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	2.4	0.8	1.5	1.2
Whole body water mass	1.2	6.9	19.6	0.3	4.4	0.9
Medication: Blood pressure	1.2	2.2	2.8	1.7	1.3	1.5
Ever smoked	1.2	2.2	3.1	1.2	1.4	1.8
Arm fat-free mass (left)	1.2	5.9	17.2	0.1	4.2	0.7
Sensitivity / hurt feelings	1.1	1.9	2.1	-1.3	-1.5	-1.4
Multivitamins +/- minerals	1.1	1.4	1.6	1.0	1.2	1.2
Comparative body size at age 10	1.1	3.0	3.7	-1.9	-1.6	-1.7
Eye problems/disorders: Cataract	1.1	1.3	2.0	1.4	0.4	1.3
Age started oral contraceptive pill	1.1	1.4	2.5	0.6	1.6	1.1
Arm predicted mass (left)	1.1	5.6	16.4	-0.3	4.0	0.4
HbA1C	1.0	1.2	1.7	1.3	0.7	1.1
Medication: Aspirin	1.0	1.3	2.5	1.0	1.6	0.7
Supplements: Vitamin C	1.0	1.2	3.1	-0.4	-1.8	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.2	6.4	0.3	2.5	-0.1
Leg fat-free mass (right)	1.0	5.3	14.9	0.4	3.9	0.9
Medication: Aspirin	1.0	1.4	1.4	1.2	1.2	1.1
Leg predicted mass (right)	1.0	5.4	15.4	0.4	3.9	0.9
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.0	-1.4	-0.8	-1.1
Basal metabolic rate	1.0	5.6	16.5	0.1	4.1	0.6
Number of operations (self-reported)	1.0	1.5	3.0	1.0	0.8	1.7
Unable to work because of sickness or disability	1.0	1.3	2.0	1.3	0.6	1.4
Bipolar Disorder (2011)	0.9	0.9	1.5	-0.8	-1.2	-0.8
Leg fat-free mass (left)	0.9	4.8	13.8	0.3	3.7	0.8
Medication: Levothyroxine sodium	0.9	1.5	2.3	0.7	1.3	1.5
Leg predicted mass (left)	0.9	4.7	13.5	0.3	3.7	0.8
Illnesses of father: Heart disease	0.9	1.2	1.7	-1.3	-0.7	-1.2
Breast cancer (self-reported)	0.9	1.0	2.0	0.9	0.5	1.4
Medication: Paracetamol	0.9	1.5	2.6	-0.9	-1.6	-1.0
Hand grip strength (left)	0.8	2.0	3.5	-1.9	-0.1	-1.6
Supplements: Glucosamine	0.8	1.0	1.9	0.7	1.4	0.8
Length of working week for main job	0.8	0.9	1.5	-0.7	-0.8	-1.2
Blood clot in the leg (DVT)	0.8	1.1	1.5	0.8	1.0	1.2
Leg pain on walking	0.8	1.0	1.3	0.9	0.9	1.1
Mood swings	0.8	1.4	2.5	-0.8	-1.6	-1.0
Medication: Lisinopril	0.8	1.0	1.9	0.2	1.4	1.1
Coronary Artery Disease (CAD)	0.7	0.8	2.0	-1.4	0.1	-0.7
Primary Biliary Cirrhosis	0.7	1.1	1.4	0.9	1.2	0.9
Ulcerative Colitis	0.7	1.0	1.7	-1.1	0.0	-1.3
Average weekly spirits intake	0.7	0.9	1.5	-1.1	-0.1	-1.2
Medication: Metformin	0.7	1.0	1.7	-1.3	-0.4	-1.1
Age when periods started (menarche)	0.7	1.7	1.8	-1.3	-1.3	-1.3
Qualifications: None of the above	0.7	1.4	2.5	0.7	1.6	1.1
Medication: Ramipril	0.7	0.9	2.0	1.4	0.3	0.7
Pulse rate	0.7	1.2	1.7	1.3	-0.7	1.2
Birth weight of first child	0.7	1.3	2.1	-1.5	-1.0	-1.0
Knee pain experienced in last month	0.7	1.1	2.4	-1.6	0.5	-0.8
Loneliness, isolation	0.7	0.9	1.0	1.0	0.9	1.0
Qualifications: nursing, teaching	0.7	1.1	1.8	-1.4	-0.9	-0.8
Illnesses of father: None of the above (group 1)	0.7	0.8	1.5	1.2	0.0	1.0
Mother’s age at death	0.7	0.9	1.5	-1.2	-0.3	-1.0
Commuting to job workplace: Cycle	0.7	0.9	1.6	0.9	0.5	1.3
Depression (Nagel 2018)	0.6	0.9	2.4	-0.5	-1.5	0.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.0	0.6	1.0	0.6
Hair/balding pattern: Pattern 2	0.6	0.7	1.1	-0.9	-0.5	-1.1
Arm fat percentage (right)	0.6	2.4	3.4	-1.1	-1.6	-1.9
Alcohol intake versus 10 years previously	0.6	0.9	1.5	-1.2	-0.4	-1.0
Breastfed as a baby	0.6	0.7	1.1	1.0	-0.2	1.0
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.3	-0.3	-1.1	-0.8
Exposure to tobacco smoke outside home	0.6	0.8	1.4	-0.6	-1.2	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.9	-0.1	-1.4	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.9	-0.4	-1.4	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.2	-1.1	-0.8	-0.5
Average weekly red wine intake	0.6	0.9	1.5	0.5	1.0	1.2
Wears glasses or contact lenses	0.6	0.7	1.7	-0.6	-1.3	-0.3
Myopia	0.6	0.8	2.5	-0.0	1.6	-0.1
Cholesterol lowering medication	0.6	0.9	1.6	-0.7	1.2	-0.7
Prostate Cancer	0.5	0.8	1.2	-1.0	-1.1	-0.3
Age at First Birth	0.5	0.7	1.7	1.3	-0.0	0.7
Mean Putamen Volume	0.5	0.6	1.4	-0.5	1.2	-0.1
Blood White Count	0.5	3.3	5.6	1.1	2.4	1.8
Diabetes (father)	0.5	0.7	1.9	0.1	1.4	0.2
Qualifications: CSEs or equivalent	0.5	0.6	1.2	0.1	-1.1	-0.8
Chronic bronchitis/emphysema (father)	0.5	0.6	1.2	1.1	-0.1	0.8
Forced vital capacity (FVC)	0.5	1.8	1.9	-1.4	1.3	-1.4
Weight	0.5	2.4	6.9	-0.4	2.6	-0.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	2.5	-1.6	1.0	-1.4
Tense / ‘highly strung’	0.5	0.8	1.2	1.1	0.6	1.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.0	0.6	-1.0	0.6
Arm fat percentage (left)	0.5	2.0	3.0	-1.1	-1.3	-1.7
Number of self-reported non-cancer illnesses	0.5	0.9	0.9	1.0	1.0	0.9
Average weekly champagne plus white wine intake	0.5	0.7	1.1	1.0	-0.3	1.0
Financial situation satisfaction	0.5	0.6	1.0	-0.5	-1.0	-0.7
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.5	-1.6	-0.1	-1.3
Schizophrenia (2018)	0.4	0.8	0.9	-1.0	-0.9	-0.8
Worry (Nagel 2018)	0.4	0.9	1.8	0.9	0.3	1.4
Ulcerative Colitis (UC)	0.4	0.8	1.2	-1.1	0.1	-1.1
Breast Cancer	0.4	0.9	1.3	-1.1	-0.5	-1.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.4	-1.2	-0.5	0.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.7	0.8	0.3	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.9	0.4	-0.6	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.7	-0.3	-1.3	-0.5
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.6	0.5	0.8	0.7
Hip circumference	0.4	1.5	3.5	-0.7	1.9	-0.8
Father’s age at death	0.4	0.6	1.1	-1.0	0.2	-0.7
Number of live births	0.4	0.6	1.8	-0.1	1.3	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	1.9	-1.4	0.5	-1.3
Medication: Paracetamol	0.4	0.7	1.0	-0.6	-1.0	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.8	0.8	0.4	0.9
Number of children fathered	0.4	0.4	1.1	-0.3	-1.1	-0.2
Age at first live birth	0.4	0.6	1.4	-0.5	-1.2	-0.5
Emphysema/chronic bronchitis	0.4	0.5	0.5	0.7	0.7	0.7
Migraine (self-reported)	0.4	0.4	1.3	-0.2	-1.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.1	-1.0	-0.7	-1.0
Alcohol drinker status: Never	0.4	0.5	0.8	0.8	-0.0	0.9
Average weekly beer plus cider intake	0.4	0.5	1.4	-0.4	-0.2	-1.2
Irritability	0.4	0.7	1.5	-0.6	-1.2	-0.4
Bipolar Disorder (2018)	0.3	0.4	0.5	0.7	0.7	0.4
Alzheimer’s Disease (in mother)	0.3	0.4	0.6	-0.8	0.1	-0.7
Alzheimer’s Disease (including proxy)	0.3	0.5	0.6	0.7	0.8	0.6
Lupus	0.3	0.4	0.9	-0.6	-0.4	-0.9
Triglycerides	0.3	0.5	1.0	-1.0	-0.4	-0.5
Medication for hormone replacement therapy	0.3	0.4	0.6	0.8	-0.0	0.7
Supplements: Zinc	0.3	0.3	0.3	0.6	-0.6	0.5
Maternal smoking around birth	0.3	0.4	1.0	0.3	1.0	0.3
High blood pressure	0.3	0.8	1.2	1.1	-0.4	1.1
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.2	0.8	-0.0	1.1
Medication: Atenolol	0.3	0.4	0.8	-0.9	-0.3	-0.6
Nervous feelings	0.3	0.6	1.1	0.7	0.2	1.0
Mouth/teeth dental problems	0.3	0.4	1.0	0.4	1.0	0.4
Illnesses of siblings	0.3	0.4	0.5	0.7	-0.5	0.6
Worrier / anxious feelings	0.3	0.6	1.7	-0.2	-1.3	-0.1
Asthma	0.3	0.6	1.3	1.1	0.3	0.7
Medication: Cholesterol lowering	0.3	0.5	0.8	-0.9	0.1	-0.8
Illnesses of mother	0.3	0.4	1.2	0.2	1.1	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	0.2	0.9	0.7
Peak expiratory flow (PEF)	0.3	0.7	1.7	-0.5	1.3	-0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	-0.1	-1.1	0.4
Forced vital capacity (FVC), Best measure	0.3	1.0	1.4	-0.9	1.2	-1.0
Body fat percentage	0.3	1.1	2.2	-0.9	-0.5	-1.5
Qualifications: College or University degree	0.3	0.9	1.4	1.1	0.1	1.2
Mean time to correctly identify matches	0.3	0.6	1.4	-0.6	-1.2	0.1
Friendships satisfaction	0.3	0.4	0.6	0.5	0.5	0.8
Medication for cholesterol	0.3	0.4	0.7	-0.6	-0.8	-0.4
Back pain experienced in last month	0.3	0.5	1.3	-1.1	-0.3	-0.1
Mineral and other dietary supplements	0.3	0.5	1.0	0.6	1.0	0.2
Illnesses of father: High blood pressure	0.3	0.4	1.2	-0.2	-1.1	-0.0
Supplements: Calcium	0.3	0.3	0.5	0.6	-0.4	0.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	0.5	0.6	0.8
Pack years of smoking	0.3	0.5	0.8	0.6	-0.9	0.5
Schizophrenia vs Biploar Disorder	0.2	0.2	0.6	-0.1	-0.8	-0.2
Crohns Disease (2017)	0.2	0.4	0.6	-0.8	0.1	-0.7
Irritable Bowel Disease (IBD)	0.2	0.6	1.0	-1.0	0.2	-0.9
Ovarian Cancer	0.2	0.2	0.5	-0.3	0.3	0.7
Body Mass Index (BMI) (2010)	0.2	0.2	0.5	0.5	-0.2	0.7
Schizophrenia (2014)	0.2	0.3	0.6	-0.4	-0.8	-0.5
Blood Platelet Count	0.2	1.8	5.0	-0.1	-2.2	-0.6
Systolic Blood Pressure	0.2	1.1	2.0	1.1	0.3	1.4
Cardiovascular Disease	0.2	0.5	0.6	0.7	0.7	0.8
Tanning	0.2	2.3	3.7	1.4	1.9	1.1
Number of treatments/medications taken	0.2	0.4	0.7	-0.5	-0.8	-0.5
Relative age of first facial hair	0.2	0.4	1.0	-0.0	1.0	0.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	0.6	0.3	0.5
Pack years adult smoking proportion	0.2	0.4	0.9	0.3	-1.0	0.2
Trunk fat percentage	0.2	0.8	1.8	-0.8	-0.0	-1.3
Taking other prescription medications	0.2	0.3	0.7	-0.8	-0.4	-0.4
Stomach or abdominal pain in last month	0.2	0.2	0.4	-0.6	-0.1	-0.4
High blood pressure (mother)	0.2	0.3	0.5	0.7	0.2	0.5
Body mass index (BMI)	0.2	0.7	1.0	-0.8	-0.7	-1.0
Trunk fat mass	0.2	0.9	1.5	-0.6	1.2	-0.9
Past tobacco smoking	0.2	0.3	0.6	-0.1	-0.8	-0.5
Had menopause	0.2	0.2	0.6	0.2	0.8	0.0
Financial difficulties in last 2 years	0.2	0.3	0.8	0.0	-0.9	-0.3
Allergy	0.2	0.4	0.8	-0.4	-0.5	-0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.3	-0.6	0.5	-0.3
Medication: Simvastatin	0.2	0.3	0.6	-0.5	0.2	-0.8
Falls in the last year	0.2	0.3	0.5	0.7	0.1	0.6
Happiness	0.2	0.3	0.5	0.7	0.4	0.4
Noisy workplace	0.2	0.2	0.4	-0.2	-0.7	-0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.4	0.4	1.2	0.1
Arm fat mass (right)	0.2	0.9	1.7	-0.9	0.1	-1.3
Hair/balding pattern: Pattern 4	0.2	0.6	1.0	1.0	-0.1	0.9
Loud music exposure frequency	0.2	0.2	0.3	-0.6	0.0	0.4
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.3	-0.6	-0.0	-0.6
High blood pressure (siblings)	0.2	0.3	0.5	-0.5	0.7	-0.2
Leg fat percentage (right)	0.2	0.6	1.0	-0.6	-0.8	-1.0
Number of full brothers	0.2	0.3	0.5	0.7	0.5	0.3
Wheeze or whistling in the chest in last year	0.2	0.4	0.6	0.8	-0.7	0.2
Shortness of breath walking on level ground	0.2	0.2	0.4	0.0	-0.6	-0.5
Medication: Omeprazole	0.2	0.2	0.2	-0.5	-0.5	0.4
Whole body fat mass	0.2	0.9	1.3	-0.9	0.9	-1.1
Suffer from ‘nerves’	0.2	0.4	0.8	0.5	0.2	0.9
Overall health rating	0.2	0.3	0.6	0.5	0.3	0.8
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.8	-0.3	-0.9	-0.2
Hypertension (Self-reported)	0.2	0.6	0.8	0.9	-0.5	0.9
Illnesses of siblings: Diabetes	0.2	0.2	0.7	0.1	0.8	0.2
Ever had bowel cancer screening	0.2	0.3	0.5	-0.6	-0.7	-0.2
Arm fat mass (left)	0.2	0.7	1.2	-0.9	0.5	-1.1
Miserableness	0.2	0.4	0.8	-0.6	-0.9	-0.3
Guilty feelings	0.2	0.3	0.4	-0.4	-0.7	-0.5
Hearing aid user	0.2	0.2	0.5	-0.2	-0.7	-0.1
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	0.3	-0.5	0.6
High cholesterol (Self-reported)	0.2	0.3	0.4	-0.7	0.4	-0.6
Leg fat percentage (left)	0.2	0.6	1.1	-0.6	-0.6	-1.0
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	-0.4	-0.2	-0.6
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	0.7	-0.2	0.3
Major Depression (MDD)	0.1	0.2	0.4	-0.6	-0.1	-0.2
Reaction Time	0.1	0.2	0.5	-0.2	-0.7	0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.3	0.6	0.3	0.2
LDL Cholesterol	0.1	0.2	0.6	-0.3	0.8	-0.1
Rheumatoid Arthritis	0.1	0.1	0.2	0.4	-0.0	0.3
Blood Eosinophil Count	0.1	1.1	1.6	-1.2	-1.0	-0.9
Smoking Status	0.1	0.1	0.2	-0.4	-0.1	-0.4
Allergy or Eczema	0.1	0.2	0.4	0.3	-0.6	0.4
Hypothyroidism (self reported)	0.1	0.3	0.8	-0.1	0.4	0.9
Respiratory disease	0.1	0.3	0.5	-0.5	-0.3	-0.7
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.4	-0.6	0.6	-0.3
Lung FEV1/FVC ratio	0.1	0.3	0.7	0.0	-0.4	0.8
Hearing difficulty/problems: Yes	0.1	0.2	0.5	-0.1	0.0	0.7
Systolic blood pressure, automated reading	0.1	0.3	0.5	0.2	-0.5	0.7
Angina	0.1	0.2	0.5	0.7	-0.1	-0.1
Diabetes (mother)	0.1	0.1	0.3	0.1	-0.5	-0.2
Severe depression (siblings)	0.1	0.1	0.3	0.2	-0.5	0.1
Impedance of leg (right)	0.1	0.5	0.8	-0.2	-0.9	-0.9
Townsend deprivation index at recruitment	0.1	0.1	0.3	0.1	-0.5	0.4
Current tobacco smoking	0.1	0.2	0.4	0.6	0.4	0.3
Average weekly fortified wine intake	0.1	0.1	0.3	0.5	0.2	0.3
Impedance of leg (left)	0.1	0.6	1.0	-0.4	-0.8	-1.0
Waist circumference	0.1	0.3	0.6	-0.4	0.8	-0.5
Alcohol usually taken with meals	0.1	0.1	0.2	-0.2	0.5	0.1
Hearing difficulty/problems with background noise	0.1	0.2	0.4	-0.1	0.6	0.4
Pain all over the body in last month	0.1	0.2	0.2	0.3	0.4	0.5
Diabetes (self-reported)	0.1	0.1	0.3	-0.2	0.6	0.1
Fluid intelligence score	0.1	0.1	0.2	0.4	0.4	-0.1
Impedance of arm (right)	0.1	0.4	0.7	0.1	-0.7	-0.8
Time employed in main current job	0.1	0.1	0.1	0.3	0.3	-0.1
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	0.6	-0.1	0.2
Depression (self-reported)	0.1	0.2	0.4	-0.2	0.6	-0.1
Lung cancer (father)	0.1	0.1	0.2	0.4	0.2	-0.1
Impedance of arm (left)	0.1	0.3	0.5	0.1	-0.6	-0.7
Exposure to tobacco smoke at home	0.1	0.2	0.2	-0.4	0.4	-0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	-0.3	-0.1	0.7
Birth weight	0.1	0.2	0.5	-0.2	0.7	0.4
Health satisfaction	0.1	0.1	0.2	0.1	-0.5	-0.1
Eye problems/disorders: None of the above	0.1	0.1	0.1	-0.3	-0.2	-0.3
Medication: Blood pressure	0.1	0.1	0.4	-0.0	-0.6	0.1
Angina (self-reported)	0.1	0.2	0.5	0.7	-0.2	-0.2
Heart disease (mother)	0.1	0.2	0.4	0.2	-0.6	-0.2
Leg fat mass (right)	0.1	0.5	0.7	-0.6	0.7	-0.8
Alcohol intake frequency.	0.1	0.1	0.4	-0.6	-0.2	0.1
Number of full sisters	0.1	0.1	0.2	0.2	0.5	-0.2
Chest pain or discomfort	0.1	0.1	0.2	0.5	-0.1	-0.1
Had major operations	0.1	0.1	0.2	-0.1	0.4	0.2
Family relationship satisfaction	0.1	0.1	0.2	-0.4	-0.1	-0.5
Smoking status: Previous	0.1	0.1	0.2	0.2	0.4	0.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	0.1	-0.6	0.3
Long-standing illness, disability or infirmity	0.1	0.1	0.1	-0.3	0.4	-0.1
Diabetes diagnosed by doctor	0.1	0.2	0.3	-0.3	0.6	-0.2
Asthma (self-reported)	0.1	0.2	0.4	0.6	0.1	0.2
Medication: Gliclazide	0.1	0.2	0.3	-0.6	0.2	-0.4
Commuting to job workplace: Public transport	0.1	0.2	0.5	0.1	-0.7	-0.1
Risk taking	0.1	0.1	0.2	0.4	0.0	0.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	0.4	0.3	0.3
Ever depressed for a whole week	0.1	0.2	0.4	-0.0	0.7	0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.2	-0.4	0.4
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	0.0	0.5	0.4
Heart disease (siblings)	0.1	0.1	0.1	0.3	-0.3	0.3
Impedance of whole body	0.1	0.6	1.2	-0.4	-0.7	-1.1
Leg fat mass (left)	0.1	0.6	0.8	-0.7	0.7	-0.9
Bipolar Disorder or Schizophrenia	0.0	0.1	0.1	-0.3	-0.2	-0.3
Neuroticism (Nagel 2018)	0.0	0.0	0.0	0.1	-0.2	0.2
Blood Red Count	0.0	0.3	0.6	0.8	-0.1	0.3
BMI	0.0	0.1	0.2	-0.2	-0.4	-0.3
Waist Hip Ratio (WHR)	0.0	0.0	0.1	0.1	-0.1	-0.2
Neuroticism	0.0	0.1	0.2	0.1	0.2	0.4
Chronotype (morning person)	0.0	0.1	0.2	0.1	0.1	0.4
Hair Pigment	0.0	0.3	0.5	-0.5	-0.5	-0.7
Vitamin and mineral supplements	0.0	0.0	0.0	0.1	0.1	-0.0
Fed-up feelings	0.0	0.0	0.1	0.2	0.2	-0.2
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.1	0.1	-0.3	0.2
Number of incorrect matches in round	0.0	0.0	0.0	0.2	-0.1	-0.1
Neuroticism score	0.0	0.1	0.2	0.0	-0.5	-0.0
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	0.1	0.3	-0.1
Glaucoma (self-reported)	0.0	0.0	0.1	-0.3	-0.0	-0.0
Worry too long after embarrassment	0.0	0.1	0.2	0.0	0.4	0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	-0.2	0.2	-0.1
Medication for pain relief, constipation, heartburn	0.0	0.1	0.2	-0.0	-0.4	0.1
Pulse rate, automated reading	0.0	0.1	0.2	0.0	-0.1	0.4
Smoking status: Current	0.0	0.0	0.0	0.0	-0.1	-0.1
Diastolic blood pressure, automated reading	0.0	0.1	0.3	0.6	0.1	0.2

Hub : Genes

DMP1

Models

Trait associations