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chr1:39,258,674-43,194,594

Best TWAS P=3.3e-63 · Best GWAS P=1.12e-55 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Aorta	CTPS1	0.10	0.00	enet	8	0.00	4.6e-01	9.366	11.0	5.5e-28	0.75	0.05	0.61	FALSE
2	GTEx	Artery Coronary	CTPS1	0.25	-0.01	enet	23	0.00	3.0e-01	2.444	7.3	4.0e-13	0.39	0.07	0.13	FALSE
3	GTEx	Brain Cerebellum	HIVEP3	0.23	0.16	lasso	6	0.19	2.8e-06	6.172	6.4	2.0e-10	0.06	0.57	0.02	TRUE
4	GTEx	Brain Cerebellum	FOXO6	0.35	0.33	enet	21	0.36	1.2e-11	3.741	7.3	2.2e-13	-0.01	1.00	0.00	FALSE
5	GTEx	Breast Mammary Tissue (Female)	CTPS1	0.12	-0.01	lasso	4	-0.01	7.5e-01	11.933	9.8	9.6e-23	0.61	0.04	0.10	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	CTPS1	0.26	0.11	lasso	6	0.08	1.6e-03	12.276	11.9	1.7e-32	0.70	0.19	0.36	FALSE
7	GTEx	Colon Transverse	SCMH1	0.16	0.07	enet	21	0.06	1.3e-03	1.321	-6.1	1.3e-09	-0.23	0.22	0.08	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	BMP8A	0.11	0.04	lasso	4	0.01	1.1e-01	4.909	5.1	2.9e-07	0.03	0.05	0.83	FALSE
9	GTEx	Esophagus Mucosa	SMAP2	0.13	0.00	lasso	3	0.03	7.4e-03	-7.593	6.3	3.5e-10	-0.13	0.05	0.32	FALSE
10	GTEx	Esophagus Muscularis	SCMH1	0.18	0.03	enet	19	0.10	1.1e-06	-2.089	-5.4	5.4e-08	-0.10	0.55	0.04	FALSE
11	GTEx	Lung	CTPS1	0.06	0.04	lasso	3	0.04	2.4e-04	12.413	13.7	1.8e-42	0.77	0.22	0.62	FALSE
12	GTEx	Nerve Tibial	SCMH1	0.16	0.03	enet	24	0.07	1.6e-05	14.309	-13.3	2.2e-40	-0.70	0.04	0.95	TRUE
13	GTEx	Skin Not Sun Exposed Suprapubic	RP11-69E11.4	0.16	0.18	lasso	3	0.15	1.0e-08	5.525	5.5	3.4e-08	0.01	0.00	1.00	FALSE
14	GTEx	Testis	SLFNL1	0.30	0.17	lasso	14	0.28	5.3e-13	15.331	11.9	1.3e-32	0.85	0.01	0.99	FALSE
15	GTEx	Testis	CTPS1	0.57	0.28	enet	17	0.38	1.0e-17	-6.854	10.1	7.0e-24	0.48	0.96	0.04	FALSE
16	METSIM	Adipose	CTPS1	0.11	0.09	enet	31	0.09	6.2e-14	-6.854	8.7	3.6e-18	0.28	1.00	0.00	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	CTPS1	0.04	0.04	enet	7	0.04	9.1e-06	11.984	9.3	1.0e-20	0.59	0.57	0.19	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLFNL1	0.03	0.01	enet	6	0.02	5.6e-05	-2.089	9.0	2.4e-19	0.58	0.10	0.75	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	COL9A2	0.03	0.04	lasso	2	0.03	6.5e-04	-8.012	8.0	9.4e-16	-0.07	0.00	0.97	TRUE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	CTPS	0.05	0.04	blup	49	0.03	1.0e-04	-6.854	7.4	1.0e-13	0.33	0.13	0.07	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	SCMH1	0.04	0.01	enet	7	0.02	2.5e-03	-0.841	-10.3	5.2e-25	-0.70	0.01	0.81	FALSE
22	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	BMP8A	0.08	0.07	blup	49	0.08	1.9e-04	4.574	5.3	1.4e-07	0.00	0.01	0.95	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	CTPS	0.06	0.00	enet	14	0.02	3.3e-03	0.021	-5.8	8.4e-09	-0.34	0.03	0.13	FALSE
24	The Cancer Genome Atlas	Prostate Adenocarcinoma	SCMH1	0.03	0.03	lasso	2	0.02	6.2e-03	15.719	-15.7	1.1e-55	-1.00	0.01	0.97	TRUE
25	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SCMH1	0.35	0.14	blup	96	0.14	1.5e-05	-7.888	10.4	2.5e-25	0.47	0.17	0.27	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	BMP8A	0.05	0.05	enet	6	0.04	9.1e-05	5.525	5.6	2.4e-08	0.02	0.00	1.00	TRUE
27	The Cancer Genome Atlas	Thyroid Carcinoma	SCMH1	0.07	0.08	blup	97	0.07	2.5e-07	14.159	-16.8	3.3e-63	-0.75	0.27	0.73	TRUE