Hub : Genes

SMAP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1530	0.0490	0.00340	0.064	NA	0.101	NA	0.126	1.4e-05	NA	5.4e-08	NA	1.2e-09
2	GTEx	Esophagus Mucosa	0.1290	0.0530	0.00630	0.004	NA	0.007	NA	0.026	1.5e-01	NA	1.1e-01	NA	7.4e-03
3	TCGA	Colon Adenocarcinoma	0.1870	0.0690	0.00015	0.075	0.042	0.032	NA	0.071	4.1e-05	0.00170	5.8e-03	NA	6.4e-05
4	TCGA	Prostate Adenocarcinoma	0.0468	0.0248	0.00590	0.024	0.026	0.012	NA	0.016	1.5e-03	0.00091	1.7e-02	NA	7.2e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.4	0.6	1.9	0.5	1.4	0.3	-0.2
Bipolar Disorder or Schizophrenia	0.1	0.1	0.3	0.1	-0.5	-0.4	-0.3
Depressed Affect (Nagel 2018)	0.3	0.7	1.1	-0.8	-0.5	0.8	-1.0
Depression (Nagel 2018)	0.5	0.8	1.9	-1.0	-1.4	0.3	-0.5
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.3	-0.9	0.1	-1.5	-1.4
Neuroticism (Nagel 2018)	0.8	1.8	3.7	-1.1	-1.9	-0.4	-1.5
Schizophrenia (2018)	0.4	0.9	3.0	-0.3	-1.7	-0.7	-0.3
Schizophrenia vs Biploar Disorder	0.4	0.5	1.1	-0.8	-1.0	0.3	0.4
Worry (Nagel 2018)	0.4	0.8	2.7	-0.1	-1.6	-0.8	-0.2
Alzheimer’s Disease (in mother)	1.9	2.2	3.6	1.6	1.6	-1.9	-0.2
Alzheimer’s Disease (in father)	0.6	0.7	1.4	-1.2	0.5	1.0	-0.1
Alzheimer’s Disease (including proxy)	0.4	0.6	2.0	0.2	1.4	-0.6	-0.1
Crohns Disease (2017)	0.1	0.3	0.9	0.5	0.9	0.2	-0.0
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	0.5	0.9	0.1	0.1
Ulcerative Colitis (UC)	0.1	0.2	0.6	-0.2	0.8	-0.1	-0.2
Major Depression (MDD)	0.4	0.5	1.8	-0.1	1.3	-0.1	-0.2
Reaction Time	0.2	0.4	1.6	-1.3	-0.0	0.2	-0.3
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.3	-1.5	0.5	-1.3	-1.3
Breast Cancer	0.0	0.1	0.2	-0.2	-0.1	-0.3	0.4
Ovarian Cancer	0.1	0.1	0.4	0.3	0.2	0.6	-0.1
Prostate Cancer	0.2	0.3	0.5	0.7	-0.3	0.6	-0.5
Age at First Birth	0.1	0.2	0.5	0.7	0.6	-0.1	-0.0
Bipolar Disorder (2011)	0.7	0.7	1.0	-0.9	-0.4	-0.8	-1.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	0.4	0.5	-0.4	-0.1
Coronary Artery Disease (CAD)	0.6	0.8	1.7	0.7	-0.3	1.3	0.9
Crohns Disease (2012)	0.4	0.7	1.5	0.9	1.2	0.6	0.2
Mean Putamen Volume	0.2	0.2	0.8	0.4	-0.9	-0.1	0.1
Fasting Glucose	1.4	1.7	4.4	0.2	-1.2	0.9	2.1
HbA1C	0.6	0.7	1.7	-1.3	0.6	-0.3	-0.8
HDL Cholesterol	0.2	0.4	1.6	-0.1	1.3	0.2	0.2
LDL Cholesterol	0.1	0.2	0.6	-0.3	0.1	0.8	0.3
Lupus	0.4	0.5	1.1	0.1	-0.2	1.1	1.0
Neuroticism (2016)	0.2	0.3	1.2	-1.1	-0.2	-0.2	0.0
Primary Biliary Cirrhosis	0.5	0.7	2.5	-0.5	-0.3	1.6	-0.1
Rheumatoid Arthritis	1.5	2.0	3.5	0.3	1.9	-1.1	-1.8
Schizophrenia (2014)	0.5	1.0	3.9	0.3	-2.0	0.1	0.3
Triglycerides	0.0	0.0	0.1	0.3	-0.2	-0.1	0.1
Type 2 Diabetes (T2D) (2012)	0.8	1.0	1.4	-1.2	0.2	-1.2	-1.1
Ulcerative Colitis	0.1	0.1	0.2	0.2	-0.2	0.4	0.3
Blood Eosinophil Count	0.1	0.8	2.3	-0.3	-0.2	-1.5	-0.9
Blood Platelet Count	0.2	2.2	3.8	1.2	2.0	1.8	0.6
Blood Red Count	0.1	1.3	3.9	-0.5	0.7	-0.8	-2.0
Blood White Count	0.2	1.4	2.0	-0.0	1.4	1.4	1.4
Heel T-Score	0.4	3.2	10.2	1.1	-3.2	-0.8	0.8
BMI	0.3	1.8	4.0	-2.0	0.4	0.8	-1.6
Height	2.1	40.3	88.7	-3.1	9.4	-4.5	-6.5
Waist Hip Ratio (WHR)	0.6	2.6	5.8	0.5	-0.7	-2.4	-2.0
Systolic Blood Pressure	1.2	5.8	16.8	4.1	0.6	-0.8	2.3
Smoking Status	0.3	0.7	2.1	1.5	-0.2	-0.5	0.7
Allergy or Eczema	0.3	0.9	1.9	-1.2	-0.3	-1.4	-0.5
Cardiovascular Disease	0.3	0.9	2.8	1.7	-0.9	0.2	-0.2
Hypothyroidism (self reported)	0.3	0.7	1.8	-0.8	-1.4	0.6	0.1
Respiratory disease	0.2	0.4	0.8	0.4	-0.2	-0.7	-0.9
Type 2 Diabetes (T2D) (2018)	0.5	0.9	3.0	-0.9	-0.1	-0.1	-1.7
Lung FEV1/FVC ratio	0.5	2.7	7.6	1.1	-2.8	1.1	0.8
Lung FVC	0.4	2.0	5.8	0.5	1.4	-2.4	-0.1
Neuroticism	0.7	1.7	4.0	-0.8	-2.0	-0.5	-1.3
Chronotype (morning person)	0.8	1.9	3.1	-0.3	-1.5	1.4	1.8
Hair Pigment	0.1	3.1	8.1	1.5	2.8	-0.9	-1.1
Tanning	0.0	0.1	0.1	-0.1	0.3	0.2	0.4
Hand grip strength (left)	0.2	0.4	1.0	-0.8	0.2	-1.0	-0.3
Number of treatments/medications taken	0.5	0.9	1.9	1.0	-1.4	0.9	0.2
Average weekly spirits intake	2.1	2.5	4.7	2.2	-0.9	-0.8	2.0
Sensitivity / hurt feelings	0.5	0.9	2.7	-0.8	0.7	-0.2	-1.6
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.2	-1.1	-0.5	0.4	-0.7
Hearing difficulty/problems: Yes	0.7	1.1	2.1	-1.5	-0.7	-0.3	-1.3
Relative age of first facial hair	0.6	1.2	4.5	-0.3	-0.1	-0.1	2.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.0	-0.1	0.3	0.8	-1.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.4	0.3	1.2	0.7	-0.3
Ever had hysterectomy (womb removed)	0.7	0.8	2.5	0.3	0.1	1.6	0.7
Systolic blood pressure, automated reading	0.8	2.4	6.4	2.5	0.3	-0.3	1.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	0.6	-0.6	-0.3	-0.0
Angina	0.9	1.2	1.6	1.2	-0.4	1.3	1.3
Medication for hormone replacement therapy	0.5	0.5	1.3	-0.3	-1.1	0.8	-0.2
Vitamin and mineral supplements	0.6	0.8	1.8	-1.0	1.4	0.6	-0.2
Supplements: Zinc	0.3	0.3	0.5	-0.5	0.4	-0.7	-0.5
Medication: Co-codamol	0.5	0.6	0.9	-0.7	-0.8	-1.0	-0.4
Medication: Metformin	0.5	0.6	2.5	-1.6	-0.0	-0.1	-0.2
Diabetes (father)	0.5	0.6	1.8	1.3	0.3	0.5	-0.4
Diabetes (mother)	1.4	1.8	6.4	0.1	2.5	0.2	-1.0
Severe depression (siblings)	0.9	1.0	1.7	1.3	1.0	0.9	0.5
Pack years adult smoking proportion	0.8	1.2	4.3	0.2	-2.1	-0.5	-0.2
Impedance of leg (right)	0.2	0.9	2.8	-0.4	-0.3	-1.7	0.7
Leg fat-free mass (left)	0.7	3.8	6.6	-1.4	2.6	0.6	-2.5
Trunk fat percentage	0.5	1.9	3.3	-1.4	1.4	-0.7	-1.8
Hand grip strength (right)	0.9	2.4	4.2	-1.2	1.1	-1.6	-2.1
Townsend deprivation index at recruitment	0.4	0.5	2.1	-0.2	-0.0	-1.4	0.0
Current tobacco smoking	1.1	1.8	3.9	2.0	-1.2	-1.2	0.7
Average weekly fortified wine intake	1.5	1.8	3.8	-0.2	-0.1	-1.8	-2.0
Maternal smoking around birth	0.8	1.1	2.3	0.5	0.8	1.1	-1.5
Fed-up feelings	0.3	0.5	1.0	-0.5	-1.0	0.8	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	2.9	-1.7	-0.2	-0.6	-1.4
Relative age voice broke	0.5	0.7	2.2	-0.2	1.5	-0.5	0.6
Taking other prescription medications	0.9	1.4	3.0	1.2	-1.1	1.7	-0.0
Age when periods started (menarche)	0.2	0.5	1.2	-1.1	0.5	0.0	0.8
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.8	0.1	-0.0	0.9	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.5	-0.6	-1.6	0.1	0.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	-0.6	-0.5	-0.6	-0.2
Qualifications: CSEs or equivalent	0.9	1.2	2.6	-0.7	-0.8	1.6	1.0
Serious illness, injury or assault to yourself	1.0	1.2	2.5	-1.2	0.9	1.6	-0.4
High blood pressure	0.7	2.0	4.5	2.1	-1.2	-1.1	-0.8
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.7	-0.8	0.8	-0.5	-0.0
Multivitamins +/- minerals	0.2	0.3	0.6	0.6	-0.3	-0.8	-0.2
Stomach or abdominal pain in last month	1.1	1.3	3.1	-0.5	-0.1	-1.8	-1.3
Supplements: Glucosamine	0.5	0.7	2.3	-0.6	0.2	1.5	0.3
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	2.3	0.6	-1.0	1.5	0.7
Medication: Atenolol	0.6	0.7	2.2	-0.5	-0.0	-0.6	-1.5
Medication: Levothyroxine sodium	0.6	1.0	3.2	-0.0	-0.5	1.8	0.7
Sitting height	1.6	11.0	29.6	-1.4	5.4	-1.3	-3.3
Chronic bronchitis/emphysema (father)	0.5	0.6	1.6	-0.0	-0.4	-1.3	-0.7
High blood pressure (mother)	0.5	0.7	2.2	1.5	-0.8	-0.2	-0.3
Body mass index (BMI)	0.4	1.5	2.8	-1.2	0.7	1.2	-1.7
Impedance of leg (left)	0.2	1.1	3.1	-0.9	0.1	-1.8	0.6
Leg predicted mass (left)	0.7	3.9	6.8	-1.4	2.6	0.6	-2.5
Trunk fat mass	0.8	3.6	6.1	-1.9	2.1	-0.6	-2.5
Waist circumference	1.4	5.3	9.9	-2.0	2.7	-0.4	-3.1
Number of incorrect matches in round	1.3	2.1	3.8	1.9	-2.0	-0.8	0.9
Past tobacco smoking	0.0	0.1	0.2	0.0	-0.5	-0.2	-0.2
Alcohol usually taken with meals	1.3	2.1	4.5	-0.7	2.1	-1.3	-1.2
Nervous feelings	0.7	1.3	3.2	0.1	-1.8	-1.4	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.0	-1.0	-0.7	-1.0	-0.2
Hearing difficulty/problems with background noise	0.7	1.1	2.2	-1.5	-0.3	-0.5	-1.4
Hair/balding pattern: Pattern 2	0.9	1.2	4.5	-0.4	-0.2	2.1	-0.0
Had menopause	1.5	1.9	4.3	0.4	2.1	-0.4	-1.7
Had other major operations	0.6	0.8	1.7	1.3	-0.1	1.1	-0.2
Forced vital capacity (FVC)	1.3	4.8	12.7	-1.0	3.6	-2.2	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.6	-0.8	-1.6	-0.2	0.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.2	-0.7	-0.6	-0.3	-1.5
Qualifications: None of the above	0.2	0.4	1.6	0.0	-0.4	-0.2	-1.3
Financial difficulties in last 2 years	0.8	1.1	3.9	0.3	0.0	-0.7	-2.0
Mouth/teeth dental problems	0.8	1.2	2.9	-0.3	0.5	1.7	1.2
Heart attack	0.5	0.6	1.6	-0.8	-0.5	1.3	-0.2
Allergy	0.4	0.9	2.2	0.9	-1.5	0.3	0.7
Pain all over the body in last month	0.8	0.8	1.4	-1.0	0.6	1.2	-0.8
Diabetes (self-reported)	0.8	1.3	2.1	-1.2	-1.2	-0.3	-1.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	-0.4	-0.7	-0.0	0.8
Medication: Ramipril	1.1	1.4	2.6	1.2	-1.2	1.6	0.3
Medication: Simvastatin	0.2	0.3	0.6	-0.7	0.1	0.5	-0.8
Fluid intelligence score	0.2	0.4	1.3	0.2	0.2	-1.1	-0.5
Illnesses of siblings	0.8	1.1	2.2	-1.5	0.0	1.2	0.9
Neuroticism score	0.5	1.1	2.2	-1.1	-1.5	-0.0	-1.0
Weight	1.5	7.3	12.8	-2.2	3.6	-0.0	-3.4
Impedance of arm (right)	0.8	3.5	5.9	1.9	-1.1	-1.8	2.4
Arm fat percentage (right)	0.1	0.2	0.3	-0.5	0.4	0.4	-0.6
Trunk fat-free mass	1.5	8.9	16.8	-2.6	4.1	0.4	-3.4
Hip circumference	1.4	6.0	13.1	-2.2	3.6	0.3	-2.5
Time employed in main current job	0.3	0.4	0.7	0.8	-0.7	-0.1	-0.7
Alcohol intake versus 10 years previously	0.6	0.9	1.7	-1.3	-0.5	0.9	-0.9
Father’s age at death	1.4	1.8	4.2	1.2	-1.2	-2.1	0.1
Worrier / anxious feelings	0.5	0.9	1.7	-1.3	-0.6	0.1	-1.2
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	4.3	-1.5	-1.6	0.1	-2.1
Falls in the last year	0.2	0.3	0.9	-0.9	0.6	-0.0	0.2
Hair/balding pattern: Pattern 3	0.6	0.9	2.5	1.0	-0.3	0.2	1.6
Number of live births	0.7	1.0	2.1	-1.4	0.5	-1.1	-0.7
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	6.2	-0.3	2.5	-1.2	-0.4
Pulse rate	0.1	0.1	0.5	0.3	0.1	-0.7	0.1
Happiness	0.3	0.4	1.3	-0.1	-0.3	0.2	1.1
Noisy workplace	0.5	0.6	1.2	-1.1	-0.8	0.0	-0.8
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.8	-1.7	-0.5	-0.6	-0.4
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	2.3	-1.3	1.5	-0.7	-1.4
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	0.1	0.7	-0.6	-0.4
Asthma	0.3	0.5	1.2	-0.3	0.9	1.1	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.8	-1.7	1.2	1.1	-0.1
Medication: Cholesterol lowering	0.5	0.8	1.2	1.1	-0.3	-0.9	-1.1
Depression (self-reported)	0.3	0.4	0.9	0.5	-1.0	0.4	-0.2
Medication: Lansoprazole	1.1	1.2	2.8	-1.7	-0.8	-1.2	-0.1
Prospective memory result	0.3	0.4	0.5	-0.1	0.7	-0.6	-0.7
Lung cancer (father)	0.3	0.4	0.8	0.9	-0.7	-0.2	0.6
Illnesses of mother	1.2	1.5	2.5	-1.5	-1.1	1.6	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.1	-0.2	1.0	-1.5	-0.4
Pulse wave Arterial Stiffness index	0.4	0.5	0.9	-1.0	0.9	0.5	-0.4
Impedance of arm (left)	0.7	3.1	4.7	1.9	-0.6	-2.2	1.9
Arm fat mass (right)	0.5	1.9	3.5	-1.2	1.6	0.4	-1.9
Trunk predicted mass	1.5	8.5	16.6	-2.5	4.1	0.4	-3.3
Standing height	1.7	16.8	39.3	-2.5	6.3	-2.4	-3.9
Length of working week for main job	0.4	0.4	1.1	-0.1	0.6	-0.5	-1.1
Exposure to tobacco smoke at home	1.5	1.7	3.6	-0.2	1.4	-1.2	-1.9
Breastfed as a baby	0.8	1.0	2.2	-0.1	1.2	-1.5	-0.6
Tense / ‘highly strung’	1.7	2.8	8.0	-0.5	-2.8	-1.6	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.7	0.3	-0.6	-0.6	-0.8
Hair/balding pattern: Pattern 4	1.0	2.5	4.5	-1.1	0.5	-2.0	-2.1
Birth weight of first child	0.1	0.2	0.5	-0.4	-0.0	0.7	-0.0
Peak expiratory flow (PEF)	0.2	0.5	2.0	0.2	1.4	-0.3	-0.1
Pulse wave reflection index	1.2	1.5	4.4	-2.1	0.1	1.2	-0.3
Ever highly irritable/argumentative for 2 days	1.4	1.7	3.4	-1.9	-0.8	0.3	-1.6
Loud music exposure frequency	0.5	0.5	1.1	-1.0	0.9	0.1	-0.4
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	3.5	-0.8	-0.7	-1.9	-1.8
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	2.8	1.2	-1.7	-1.1	-0.1
Blood clot in the leg (DVT)	0.7	0.9	2.3	-0.4	0.2	-1.1	-1.5
Medication: Paracetamol	0.4	0.7	2.2	-0.7	-1.5	-0.1	-0.1
Headache pain in last month	0.9	1.5	4.0	-0.6	-0.4	-1.3	-2.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	3.5	-1.9	1.0	0.9	1.0
Glaucoma (self-reported)	0.7	0.8	2.4	0.4	1.6	0.7	-0.5
Gout (self-reported)	0.7	1.0	2.9	-0.5	0.9	1.7	0.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	2.4	-0.0	-0.7	1.6	0.7
Medication: Amlodipine	0.6	0.9	2.5	-0.6	-1.6	0.4	-0.8
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.2	1.1	0.2	-0.9	-0.2
Birth weight	0.2	0.4	0.6	0.3	0.7	-0.7	-0.6
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.0	0.5	0.7	1.0	0.7
High blood pressure (siblings)	1.2	1.7	3.1	1.8	-1.7	0.1	1.0
Forced vital capacity (FVC), Best measure	0.9	3.5	7.0	-0.7	2.3	-2.6	-1.1
Body fat percentage	0.4	1.5	2.5	-1.5	1.0	-0.4	-1.6
Leg fat percentage (right)	0.6	2.2	5.9	-2.4	0.1	-0.1	-1.7
Arm fat-free mass (right)	2.2	11.1	19.2	-2.8	4.4	0.1	-4.2
Exposure to tobacco smoke outside home	0.0	0.1	0.1	0.0	-0.1	0.4	0.3
Comparative body size at age 10	0.2	0.5	1.8	0.2	-0.2	1.3	-0.0
Number of full brothers	0.3	0.3	0.8	0.5	-0.1	0.9	-0.5
Worry too long after embarrassment	0.5	0.9	1.6	-1.2	-0.6	0.3	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.1	0.4	0.4	-1.1	-0.8
Wheeze or whistling in the chest in last year	0.3	0.5	1.3	0.8	0.2	-0.4	-1.1
Number of children fathered	1.2	1.4	2.0	1.4	1.2	1.2	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	2.0	-1.4	1.0	-0.9	-1.1
Age at first live birth	0.8	1.5	3.4	-1.5	-0.2	-1.8	-0.5
Pulse wave peak to peak time	0.3	0.4	0.9	0.7	-0.3	-1.0	-0.0
Health satisfaction	0.6	0.8	2.8	1.7	0.6	-0.0	0.2
Shortness of breath walking on level ground	1.4	1.7	2.9	-0.9	0.8	-1.7	-1.5
Qualifications: College or University degree	0.7	2.2	5.4	-0.6	2.3	-1.6	-0.5
Eye problems/disorders: None of the above	0.2	0.2	0.4	-0.4	-0.4	-0.7	-0.3
Mouth/teeth dental problems: Loose teeth	1.5	1.8	4.4	-0.4	0.8	-1.4	-2.1
Emphysema/chronic bronchitis	0.6	0.7	1.5	1.2	0.5	-0.6	-0.8
Medication for pain relief, constipation, heartburn	0.2	0.4	0.7	-0.2	0.7	-0.9	-0.5
Neck or shoulder pain in last month	0.8	1.1	3.6	0.3	-0.7	-0.6	-1.9
Medication: Blood pressure	1.1	2.0	6.4	2.5	-1.2	0.1	0.3
Angina (self-reported)	0.8	1.1	1.6	1.3	-0.1	1.2	1.2
Migraine (self-reported)	1.2	1.5	3.2	-0.0	1.8	-0.3	-1.7
Medication: Ibuprofen	1.6	1.9	2.8	-1.6	1.4	1.7	0.5
Medication: Allopurinol	0.9	1.2	4.2	0.3	0.8	2.0	0.2
Medication: Omeprazole	0.9	1.1	3.7	0.2	0.1	1.9	0.8
Medication: Seretide 50 evohaler	2.1	2.4	6.4	-2.5	0.8	-0.0	-1.6
Mean time to correctly identify matches	0.2	0.4	1.2	-1.1	-0.5	0.3	-0.2
Heart disease (mother)	0.3	0.3	0.4	0.7	-0.6	-0.6	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	5.2	0.6	2.3	-1.0	-0.1
Whole body fat mass	0.7	2.9	5.1	-1.9	1.7	-0.1	-2.3
Leg fat mass (right)	0.7	2.6	4.6	-2.1	1.1	0.6	-2.1
Arm predicted mass (right)	2.2	11.0	18.1	-2.9	4.2	0.1	-4.3
Pulse rate, automated reading	0.2	0.5	1.0	-0.8	-1.0	0.6	0.2
Alcohol intake frequency.	1.0	2.2	7.1	-0.9	1.0	-0.1	-2.7
Comparative height size at age 10	1.2	6.4	9.4	-1.9	3.1	-2.1	-2.8
Number of full sisters	0.5	0.6	2.1	0.4	0.5	1.4	0.1
Suffer from ‘nerves’	0.8	1.3	3.2	-0.5	-1.1	-1.8	-0.8
Overall health rating	0.4	0.9	1.4	0.4	0.9	1.2	-1.0
Chest pain or discomfort	0.7	1.0	1.5	0.5	1.2	1.1	-1.0
Had major operations	0.6	0.7	1.1	0.9	1.0	1.1	-0.1
Age at last live birth	0.5	0.8	1.9	-0.7	-1.4	-0.8	0.4
Family relationship satisfaction	0.1	0.1	0.4	0.4	0.2	-0.6	-0.1
Leg pain on walking	0.3	0.4	0.6	0.5	0.8	0.6	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.0	0.2	0.4	0.9	1.4
Commuting to job workplace: Car/motor vehicle	0.6	0.6	1.4	0.0	1.2	0.0	-1.1
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	4.1	-0.1	-1.3	0.5	2.0
Medication: Aspirin	0.2	0.3	0.7	0.5	0.2	0.8	-0.5
Supplements: Vitamin C	0.0	0.1	0.1	-0.0	-0.3	-0.2	-0.3
Knee pain experienced in last month	0.8	1.2	2.9	-0.5	-0.3	1.7	-1.3
Hypertension (Self-reported)	0.7	1.8	4.7	2.2	-1.2	-0.9	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.1	0.9	-0.9	1.8	1.0
Illnesses of father: Heart disease	0.4	0.6	2.1	1.4	-0.3	0.4	0.4
Illnesses of siblings: Diabetes	0.6	0.7	1.9	-0.4	0.3	-0.9	-1.4
Smoking status: Previous	0.3	0.5	1.0	0.2	0.9	1.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.9	-1.2	2.2	-0.1	-0.5
Whole body fat-free mass	1.3	7.3	13.5	-2.2	3.7	0.4	-3.3
Leg fat-free mass (right)	0.8	4.5	9.0	-1.5	3.0	0.5	-2.6
Arm fat percentage (left)	0.1	0.3	0.6	-0.4	0.5	0.3	-0.8
Average weekly red wine intake	0.8	1.2	2.2	1.1	1.1	-1.5	0.3
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.3	-0.5	-0.5	0.9	1.5
Mood swings	0.5	0.9	2.2	-1.5	-0.8	0.9	0.1
Loneliness, isolation	0.5	0.7	1.3	-0.5	-1.1	0.8	-0.9
Long-standing illness, disability or infirmity	0.1	0.2	0.4	-0.1	-0.5	0.1	-0.7
Ever had bowel cancer screening	1.0	1.1	1.8	1.4	-1.2	-0.4	1.1
Diabetes diagnosed by doctor	0.8	1.3	2.3	-1.5	-1.2	0.3	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.9	-0.8	-0.4	0.9	0.3
Friendships satisfaction	0.4	0.5	1.1	0.8	-0.4	0.4	1.0
Qualifications: nursing, teaching	0.7	1.1	2.7	-0.4	-1.7	-0.9	-0.8
Commuting to job workplace: Walk	1.0	1.1	3.4	-1.8	-1.0	-0.4	-0.1
Eye problems/disorders: Cataract	0.2	0.2	0.9	0.3	0.1	0.1	1.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.5	-1.0	0.8	0.1	-1.2
Medication for cholesterol	0.2	0.4	0.8	0.1	0.9	-0.7	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.4	0.9	-0.9	-1.2	0.9
Back pain experienced in last month	0.5	0.7	2.0	-0.7	0.3	0.3	-1.4
Mineral and other dietary supplements	0.5	0.6	1.5	-0.2	0.7	-1.2	-0.7
Breast cancer (self-reported)	0.2	0.2	0.6	0.2	-0.1	-0.8	0.4
Asthma (self-reported)	0.3	0.6	1.1	-0.7	0.8	1.1	-0.3
Osteoporosis (self-reported)	0.3	0.4	0.9	0.9	0.1	0.4	0.7
Osteoarthritis (self-reported)	0.5	0.6	1.3	-0.3	0.2	1.1	-1.1
Medication: Aspirin	0.4	0.5	1.2	0.9	0.1	1.1	0.0
Medication: Gliclazide	0.3	0.3	0.9	-0.9	-0.0	0.0	0.5
Illnesses of father: None of the above (group 1)	0.6	0.7	2.3	-1.5	0.0	0.0	-0.8
Smoking status: Current	0.8	1.3	2.2	1.5	-1.0	-1.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.2	2.2	1.5	-1.1	-1.1	0.2
Whole body water mass	1.4	7.8	14.1	-2.3	3.8	0.4	-3.4
Leg predicted mass (right)	0.8	4.4	8.8	-1.4	3.0	0.6	-2.5
Arm fat mass (left)	0.4	1.7	3.2	-1.0	1.5	0.6	-1.8
Number of self-reported non-cancer illnesses	0.5	0.9	2.2	0.9	-1.5	0.6	-0.1
Average weekly champagne plus white wine intake	0.3	0.4	0.7	-0.8	0.6	-0.6	0.1
Miserableness	0.5	0.9	2.7	-1.6	-0.5	0.5	-0.7
Guilty feelings	0.6	0.9	2.3	-0.8	-0.4	-0.6	-1.5
Wears glasses or contact lenses	0.5	0.6	1.7	-0.9	0.1	-0.1	-1.3
Ever taken oral contraceptive pill	1.6	1.8	2.2	1.4	-1.1	-1.5	1.4
Hearing aid user	0.8	0.9	1.3	-1.1	-0.9	-1.0	-0.9
Mother’s age at death	0.8	1.0	1.8	-1.1	-0.7	-1.4	-0.6
Financial situation satisfaction	0.4	0.5	1.1	-0.8	-0.0	1.0	0.7
Tinnitus: Yes, now most or all of the time	1.0	1.1	3.2	-0.8	-1.8	0.8	0.2
Commuting to job workplace: Public transport	0.5	0.6	1.2	1.0	-0.3	-0.1	1.1
Eye problems/disorders: Glaucoma	0.6	0.7	1.4	0.5	1.1	-0.1	-1.2
Medication: Blood pressure	0.4	0.8	2.6	-0.3	-0.2	-0.6	-1.6
Pain type(s) experienced in last month: Hip pain	1.5	1.9	4.5	0.6	-1.0	-1.3	-2.1
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.4	1.2	-0.7	0.8	1.1
High cholesterol (Self-reported)	0.3	0.6	1.7	0.4	-0.2	1.3	-0.7
Medication: Bendroflumethiazide	1.1	1.7	3.5	1.9	-1.6	0.6	0.6
Medication: Paracetamol	0.2	0.4	1.0	-0.4	-1.0	0.5	0.1
Medication: Lisinopril	0.4	0.5	0.9	0.5	-0.5	-1.0	-0.7
Medication: Atorvastatin	1.1	1.4	5.0	2.2	-0.7	0.0	-0.0
Illnesses of father: High blood pressure	2.1	2.6	7.2	2.7	0.1	0.9	1.5
Alcohol drinker status: Never	1.5	1.8	4.2	-0.9	1.5	0.4	-2.0
Ever smoked	0.2	0.3	0.6	-0.5	0.7	-0.8	-0.2
Basal metabolic rate	1.3	7.1	13.6	-2.1	3.7	0.4	-3.2
Leg fat percentage (left)	0.7	2.5	7.2	-2.7	0.3	0.1	-1.6
Arm fat-free mass (left)	1.9	9.7	17.2	-2.5	4.2	0.2	-3.9
Number of operations (self-reported)	0.9	1.4	4.2	2.0	-0.6	0.6	-0.8
Average weekly beer plus cider intake	0.2	0.3	0.6	0.5	0.1	-0.7	-0.8
Irritability	0.9	1.6	3.0	-1.2	-0.2	-1.4	-1.7
Risk taking	0.6	0.9	2.5	0.5	0.4	-1.6	-0.7
Ever had prostate specific antigen (PSA) test	0.7	0.9	1.6	-1.1	-1.3	-0.8	-0.4
Fractured/broken bones in last 5 years	0.3	0.4	0.9	0.9	0.2	-0.7	0.2
Age started oral contraceptive pill	0.8	1.0	1.7	0.7	1.3	-1.3	-0.3
Diastolic blood pressure, automated reading	0.0	0.1	0.3	0.6	-0.0	0.0	-0.1
Ever depressed for a whole week	0.1	0.1	0.2	-0.3	-0.4	-0.0	-0.4
Unable to work because of sickness or disability	0.4	0.5	1.3	1.2	0.7	0.1	-0.0
Commuting to job workplace: Cycle	1.0	1.3	4.1	0.7	-0.2	-2.0	-0.7
Myopia	0.3	0.4	1.0	-0.3	1.0	-0.5	-0.5
Vascular/heart problems diagnosed by doctor	0.5	1.4	4.2	-2.0	1.2	0.2	0.3
Cholesterol lowering medication	0.4	0.7	2.4	-0.2	0.0	1.6	0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.4	-0.4	-0.0	1.2	-0.1
Pain experienced in last month	1.3	2.1	6.9	1.0	-0.7	0.5	2.6
Supplements: Calcium	0.8	0.9	3.2	1.8	-0.4	0.0	-0.2
Basal cell carcinoma (self-reported)	0.4	0.4	0.7	0.8	-0.6	0.2	0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.7	-0.7	-0.2	1.3	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.4	-0.1	0.1	-0.8	-1.2
Heart disease (siblings)	1.5	1.8	4.0	-0.3	2.0	-0.4	-1.7
Alcohol drinker status: Previous	1.6	1.8	4.2	-1.2	1.2	-0.4	-2.0
Pack years of smoking	0.7	1.0	3.1	-0.1	-1.8	-0.6	-0.7
Impedance of whole body	0.3	1.7	5.5	0.6	-0.1	-2.3	1.0
Leg fat mass (left)	0.7	2.6	4.5	-2.1	1.2	0.6	-2.1
Arm predicted mass (left)	2.0	10.0	18.0	-2.7	4.2	0.3	-3.8